<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYX2</accession>
    <name>A0A151LYX2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme E2 N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">UBE2N</name>
        <name evidence="2" type="ORF">Y1Q_0020047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYX2"/>
    <dbReference type="STRING" id="8496.A0A151LYX2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO17430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="12573" checksum="745ABA1176F0D427" modified="2016-06-08" version="1">MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIADKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M086</accession>
    <name>A0A151M086_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Growth factor receptor-bound protein 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GRB14 adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GRB10</name>
        <name evidence="17" type="ORF">Y1Q_0011565</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRB7/10/14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M086"/>
    <dbReference type="STRING" id="8496.A0A151M086"/>
    <dbReference type="GeneID" id="102570859"/>
    <dbReference type="KEGG" id="amj:102570859"/>
    <dbReference type="CTD" id="2888"/>
    <dbReference type="eggNOG" id="KOG3751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5990423at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16139">
        <property type="entry name" value="RA_GRB14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10414">
        <property type="entry name" value="SH2_Grb14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000015">
        <property type="entry name" value="Growth factor receptor-bound protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000714">
        <property type="entry name" value="Growth factor receptor-bound protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000133">
        <property type="entry name" value="growth factor receptor-bound protein 14 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015042">
        <property type="entry name" value="BPS-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035034">
        <property type="entry name" value="Grb14_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF22">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08947">
        <property type="entry name" value="BPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="Ras-associating" evidence="16">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="147"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="351"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO17929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="452" mass="52017" checksum="2D2D383223164842" modified="2016-06-08" version="1">MNLYARRVTLPTVTPIVLQKRVIKVYSEDDTSRALEVPSDITARDVCQLLILKNHYIDDHSWTIFEHLTRIGLERALEDHELVMEVLSNWAMEEENRLYFRKNYAKYEFFKNPGSFFPEHMVSFSNETSGAIGHTEILQMFLSSSTYPEIHGYLHAKEQGKKSWKKNYFLLRRSGLYFSTKGTSKEPRHLQFFCEFSNSDMYMSLAGKKMSGAPANYGFCFKPNKSGGTRDLKQLCADDEQSRTCWMTAIRLLKYGMQLYQNYMHPYQGRSSFNSLNISPTRSISENSLVAMDFSGHRSRVIENPTEALSVAVEEGLAWRRKGCLRLNAHGSPSASQTATPNIAIHRSQPWFHHKISRDEAQRLILQQGLIDGVFLVRDSQSNPKAFVLSLSHGLKIKHFQIVPLEDDGKQFYTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M181</accession>
    <name>A0A151M181_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(P)(+)--arginine ADP-ribosyltransferase</fullName>
            <ecNumber evidence="10">2.4.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mono(ADP-ribosyl)transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0012770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19149"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:15087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142554"/>
            <dbReference type="EC" id="2.4.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Arg-specific ADP-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.31" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03006834">
        <property type="protein sequence ID" value="KYO18278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M181"/>
    <dbReference type="eggNOG" id="ENOG502QUE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044194">
        <property type="term" value="C:cytolytic granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106274">
        <property type="term" value="F:NAD+-protein-arginine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.176.10:FF:000001">
        <property type="entry name" value="NAD(P)(+)--arginine ADP-ribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.176.10">
        <property type="entry name" value="Toxin ADP-ribosyltransferase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050999">
        <property type="entry name" value="ADP-ribosyltransferase_ARG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000768">
        <property type="entry name" value="ART"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339">
        <property type="entry name" value="ADP-RIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339:SF24">
        <property type="entry name" value="T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01129">
        <property type="entry name" value="ART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00970">
        <property type="entry name" value="RIBTRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01291">
        <property type="entry name" value="ART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51996">
        <property type="entry name" value="TR_MART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO18278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="313" mass="35549" checksum="5703D30A071ACE4F" modified="2016-06-08" version="1">MHSSAPQTLGFKQFAGFRHLAGEMLWTRGILLLVCLWFSSLDQNLADAREITPNMMPDAVDDQYYGCTDDMERKAPALLEQELNGSKQFRKQWENTATKWEKVTADHSIQFPPDFTESHGRAVIVYTDKKFHTDFMNAVKKNGKSSAYYKANFKFKAVHYYLTRALHLLREKAEWRYTDVVYRGTKDIYQYKEGEEIRFGHFTATSSSESIAKEFGTTTFYTIHTTLGVNIMKLSYNASQKEVLIPVNEVFTVFPKQGSNRYVLKSTGRTYNHLNCAYSSSGGITFPGQMRPSLLGGAVLLLNAATLRLFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1M8</accession>
    <name>A0A151M1M8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Putative ATP-dependent RNA helicase DHX57</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAH box protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0008511</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable ATP-binding RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M1M8"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17985">
        <property type="entry name" value="DEXHc_DHX57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23825">
        <property type="entry name" value="RWD_DHX57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14317">
        <property type="entry name" value="UBA_DHX57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000325">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000284">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042615">
        <property type="entry name" value="DHX57_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="18">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="489"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="765"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="387"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO18392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1322" mass="149986" checksum="976F0E05F6453204" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2G2</accession>
    <name>A0A151M2G2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA acetyltransferase, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ACAT2</name>
        <name evidence="9" type="ORF">Y1Q_0009119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2G2"/>
    <dbReference type="STRING" id="8496.A0A151M2G2"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="277"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="5">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO18661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="397" mass="41371" checksum="D616CD996360FB8E" modified="2016-06-08" version="1">MSGEGGDAVVVVSAARTPVGSFNGALSAMQAHELGSIVIKEVLKRANINPEEVSEVIFGQVLTAGAGQNPVRQASVGAGIPYAVPAWSCQMICGSGLKAVCLGAQSLMTEDSSIVVAGGMESMSKAPHLIHMRAGVKMGETSLQDSIICDGLRDVFYQYHMGITAENVAKQWKISRAEQDQLAVQSQTRAEGAQKAGYFDKEIVSVLVPSRKGPVEVKTDEHPRHGSNLETMAKLKPCFLTDGTGTVTAANASGINDGAAAVILMKKSEAARRSLLPLAQIVSWAQVGLDPSIMGVGPIAAIKKAVNKAGWTLEQVDLFEINEAFASVAAAIAKELKLNPEKVNIEGGAIALGHPLGASGCRILVTLLYALERTGGKRGVAALCIGGGMGIAMCIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2W3</accession>
    <name>A0A151M2W3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LGALS8-1</name>
        <name evidence="11" type="ORF">Y1Q_0009250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2W3"/>
    <dbReference type="STRING" id="8496.A0A151M2W3"/>
    <dbReference type="eggNOG" id="KOG3587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000054">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000073">
        <property type="entry name" value="Galectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF22">
        <property type="entry name" value="GALECTIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 9" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="10">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="10">
        <location>
            <begin position="186"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO18838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="314" mass="35254" checksum="2B014879F0101813" modified="2016-06-08" version="1">MMSLDKLENAVSNPVIPYVGSILSGLLPGELIVIRGSIPDDADRFQVDLQCGSSVKPRADVAFHFNPRFKRSGCIVCNTLHREKWGSEEITYEMPFQKGKPFKIVFMVLKDKFQVAVNGKHLLLYKHRINLEKIDTVGIYGKVQIEIIEFVSNKSLQGSQPSSLGITKINTENGTVPDGSQFAVPYLARLNSALGPGRTVTIKGEVNKNPNSFTINLKSSDSKDIALHLNPRIKNKVFVRNSYLHDSWGEEEKEVAHFPFSPGMYFELIILCDAHEFKVAINGVHVLEYKHRFKQLGMINLLEITGDIELLDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5R0</accession>
    <name>A0A151M5R0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">E3 ubiquitin-protein ligase TRIM39</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RING-type E3 ubiquitin transferase TRIM39</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Tripartite motif-containing protein 39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">TRIM39</name>
        <name evidence="27" type="ORF">Y1Q_0006821</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 29">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03006526">
        <property type="protein sequence ID" value="KYO19856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5R0"/>
    <dbReference type="STRING" id="8496.A0A151M5R0"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19780">
        <property type="entry name" value="Bbox2_TRIM39-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13745">
        <property type="entry name" value="SPRY_PRY_TRIM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000171">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035033">
        <property type="entry name" value="PRY/SPRY_TRIM39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="15 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="25">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="26">
        <location>
            <begin position="429"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="341"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO19856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="628" mass="72005" checksum="09FE2CF0A4A39BAF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6M6</accession>
    <name>A0A151M6M6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Toll-like receptor 22 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TLR22</name>
        <name evidence="16" type="ORF">Y1Q_0010730</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6M6"/>
    <dbReference type="STRING" id="8496.A0A151M6M6"/>
    <dbReference type="eggNOG" id="KOG4641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF522">
        <property type="entry name" value="LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="15">
        <location>
            <begin position="332"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO20157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="495" mass="57052" checksum="F8B08146C84EDAD9" modified="2016-06-08" version="1">MNSIKKGTFRNLTSLQFLNLVDNQISTIEPGAFEGLSSLQTLLLGSNRITGNTLQKGIFKGASSIVELQLFNNYISYESAGKLDNPPFILLKSLKKLTLNSQRHLGLQNFPSNFLQGLESIVSIHAGNLDISSLHPDTFSYTPGLQELDLSNNPISPINLDLFQPVANLTELHLNKIGLQSLNFVLHANFSKLAVLRVATNELDVIKPNHIAALPFLTFLDLRHNPFTCSCNNKAFLNWSLNSLKTQVIYLCEYTCAFPPSSKGDKLWTFDFSSCTANLDFILFISNSTLVILLMIVCLFYHWRWQGIYAYHLLLAYIYDNRHKRKRQHKKYDYDAFVSYNTEDEKWVINDLLPKLEDEYHWKLCLHHRDFEPGRSILDNIVDNIYGSRKTICVITRHYLESEWCSKEIQVASFRLFDEHEDVLVLIFLEDIPAGYLSPYHRMRKLIKKKTYLAWPQEKEKIPLFWLKLHMALKTSEGKVDEDPILSVIVPDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6N2</accession>
    <name>A0A151M6N2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6N2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11485" checksum="305C2033111C66EB" modified="2016-06-08" version="1">MPPTAPCSKIGPHAVLHTQSSMQGHAIQPLRFPMGFSLMTIEKALIAALKKRNNHSHETQINSNVQKILEFSSLLVSNQHLRDHKETWENHTWEQRPEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6T7</accession>
    <name>A0A151M6T7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6T7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7020" checksum="3260DE78E904C5E8" modified="2016-06-08" version="1">MGNAESVLLGTTIRVGSGSHSAAVLLTLSEILCIALPLFPICHCYARKTQGSRSSAEDPYVNINGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M883</accession>
    <name>A0A151M883_ALLMI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M883"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="134" mass="14379" checksum="C37A9C7D2710D918" modified="2016-06-08" version="1">MEVVTVGIQLFQWKGRYPQGRGQNVCYSSCDHLKKISEVVSVPHPFHFQPCGMHDGKDLRGMAEFLPAEGSPLSQSLSASSGIHGFKRDMYPGSSKLALAGYPNLQGCQHLPLPGHSFASCHSGLSEGLTSGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8I8</accession>
    <name>A0A151M8I8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 13C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">VPS13C</name>
        <name evidence="10" type="ORF">Y1Q_0012625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M8I8"/>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF22">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="872"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1955"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="3034"/>
            <end position="3147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1355"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO20760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="3172" mass="358163" checksum="033064D710ABE480" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M999</accession>
    <name>A0A151M999_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Lactadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0001380</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HAPLN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M999"/>
    <dbReference type="STRING" id="8496.A0A151M999"/>
    <dbReference type="eggNOG" id="ENOG502QVK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05877">
        <property type="entry name" value="Ig_LP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03518">
        <property type="entry name" value="Link_domain_HAPLN_module_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03519">
        <property type="entry name" value="Link_domain_HAPLN_module_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000226">
        <property type="entry name" value="EGF-like repeat and discoidin I-like domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000001">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000002">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050691">
        <property type="entry name" value="Hyaluronan_bind_Proteoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804">
        <property type="entry name" value="AGGRECAN/VERSICAN PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804:SF40">
        <property type="entry name" value="HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01265">
        <property type="entry name" value="LINKMODULE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="6" id="KW-0373">Hyaluronic acid</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584897" evidence="11">
        <location>
            <begin position="17"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="139"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="306"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="519"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="15">
        <location>
            <begin position="645"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="15">
        <location>
            <begin position="745"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO21075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="849" mass="95538" checksum="1CC3DFF4663C4FB7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9B1</accession>
    <name>A0A151M9B1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia-and flagella-associated protein 161</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9B1"/>
    <dbReference type="STRING" id="8496.A0A151M9B1"/>
    <dbReference type="KEGG" id="amj:102569034"/>
    <dbReference type="eggNOG" id="ENOG502QRDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2126411at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M9B1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055325">
        <property type="entry name" value="CF161"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24274:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24569">
        <property type="entry name" value="CFAP161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36363" checksum="6619E7A294C39715" modified="2016-06-08" version="1">MSGRGYNYSYSYSAGVLVGNWNEDVCLEEGLLKDFLHKRERGELLIQKSRSLKNNLLKKIPLSISKDGFVHFGDTVMLVNPDNNKLPMENYPAVCGNLSLAVLPDEVAVHTADSLQASCGVSAIKSMNPVGRNTFRILSVEGNSMGEPIRFGQNFGLGATGGFADQMLYLGSDHKSFMRFAKKSYLQQVFLTDELSYLTCWQATFLDPQLRLEYEGFPVPANSKLLITHCHTNRGLAVPRNYWISSYFGKEYEVICHTYLDSHKAEEDKNYWIIVTGNPSDEESTMFDRPKPLSEETREHPSEETRDREMKFMPEHNKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB52</accession>
    <name>A0A151MB52_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0000466</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MB52"/>
    <dbReference type="eggNOG" id="KOG1820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000052">
        <property type="entry name" value="Cytoskeleton associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000050">
        <property type="entry name" value="Cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000068">
        <property type="entry name" value="cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000063">
        <property type="entry name" value="Putative cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="15">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="15">
        <location>
            <begin position="263"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="15">
        <location>
            <begin position="580"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="15">
        <location>
            <begin position="843"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="15">
        <location>
            <begin position="1184"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="499"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="806"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1071"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1413"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1989"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1096"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1122"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1434"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1996"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2015"/>
            <end position="2029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO21757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2029" mass="224741" checksum="05D7005BAB4A4E2C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC70</accession>
    <name>A0A151MC70_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MC70"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="127" mass="14811" checksum="7CFF83E853C150A7" modified="2016-06-08" version="1">MREAMREGKTWIGAWYRGQSRKKIFLAQAPWVEDGEEWSAYFRKIKETKKEAMTSPVDGAEVEHQSIEGILEMVVAFYQKLYAAQPGDPRAMQDCLQRLTQVLREDEGQKLVEEWMLEEVSTMLCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MD71</accession>
    <name>A0A151MD71_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0003031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MD71"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031461">
        <property type="entry name" value="DUF4679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15728">
        <property type="entry name" value="DUF4679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="372" mass="41619" checksum="178F109BD4FF5159" modified="2016-06-08" version="1">MRETEAGQSPLDPARIRPQQGSPETPDLEELIEAIIDSSTTRQAICDLQYNLLVELLNKYPSSSCLSVEGAVVEYPICLLCYKCLESRCTHQGQHKTAALPKLVVFPTHLSIETQGNKRRMKMSLGFMLKLKRRQAQEWQITEGIMLKLNGRQCQEWQLTECPLGERNTKIQKEMKTSPESLQGSDQSANIKHFTFQMPESISKKIIKSQGRKTADTDFHLGSPAGPQQQSPSDVTSPSSHKRQFPQKGRKRPDRTVIRAPREQPKVVSASTSTTDLHKTGQTAPYVAKPLTKPKPATALLQTDGASSYPAAGEKKPKPGTLFRPGNRVPLHRRILSFCKQTFAEQCSKMPELKFTKSPFWQGRASKGIWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDM8</accession>
    <name>A0A151MDM8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0003150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDM8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584972" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="9210" checksum="5B7A7FE8628D91EB" modified="2016-06-08" version="1">MKEAGSHLVTVLFTVLSTRTPCLTGLHTDYHRKNSEVPIMCEILHLQKPEKIKELCRVLRKSQLQQYCKVREDPTKFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEJ2</accession>
    <name>A0A151MEJ2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0003290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEJ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="161" mass="17755" checksum="2DE2F8F2852F9310" modified="2016-06-08" version="1">MPSQGLCNGAAAASDTAKGLQEATAKPPLPPAPQPLGPPCQLDWWQQLVQRDGDDKQWVNTFWLTQATFTDLLHQLWPHLECQDTGMCPALHTNTCLALELFSSKTCLALELLNLATPASLWYMGHLFSVGKATTGRLSWRCVVASRMCWWTLSSMSATPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEQ1</accession>
    <name>A0A151MEQ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Torsin-4A isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TOR4A</name>
        <name evidence="9" type="ORF">Y1Q_0005496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEQ1"/>
    <dbReference type="STRING" id="8496.A0A151MEQ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF1">
        <property type="entry name" value="TORSIN-4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO23006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="370" mass="42841" checksum="1B6C6C52A4B7BB39" modified="2016-06-08" version="1">MQLLWMPPVRPRRRRDVRRQSEWFREGSNMDGEPPCPKPPTLPHKISLVSSPMRAVIRLRRKVRIQKKNCLQVDLNKDKSPELVQTRLLQRQISLNRTNLCSSSISLFNQSSFENSRYFTFDTSRDQCTLNKYKRKKRRRKSKILNAIENLDDNLQKYDLDGLEKTMHREVFGQKLAVEKIMELLKDYLATHIHNKPLVISLNGPTGVGKSHVGWLLAKHFRSVMDSDFVLQYFVMHHCPNKEATLGCQLDLSKKISDIVTRAETEEKIPLFILDEVEHIPPVLLDTLSRFFEPNQTNEFLNAIYILISNIGDSEITKTNWTIQSQVIIILVAVQRCCTMTTERWETAGQLSPKTCPRLSQPCMGSVEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MET6</accession>
    <name>A0A151MET6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MET6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO23042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="105" mass="12190" checksum="2FAC960C0952B318" modified="2016-06-08" version="1">MRADNARLEIPRRHEASDKEPEEAPEEECASGSREHTGSYIDKNNLCKLRRQPLQRRKKQAHEDPQYIRTNCQGTSIVLFSPKAAWKMYSHGPTRTDMERIILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGW9</accession>
    <name>A0A151MGW9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="15">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Y1Q_0002375</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58433"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:43485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGW9"/>
    <dbReference type="STRING" id="8496.A0A151MGW9"/>
    <dbReference type="eggNOG" id="KOG1265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120548">
        <property type="term" value="F:phosphatidylinositol phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16208">
        <property type="entry name" value="EFh_PI-PLCbeta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000048">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.240:FF:000003">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028400">
        <property type="entry name" value="PLC-beta1_EF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF12">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15 18" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9 15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="22">
        <location>
            <begin position="475"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="591"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="405"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="767"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1001"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1101"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="796"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1109"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO23764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1146" mass="131060" checksum="FB14C5321F3EED34" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIM7</accession>
    <name>A0A151MIM7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIM7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585216" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO24333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7710" checksum="66384D4407A76570" modified="2016-06-08" version="1">MMIGVTWMCTVLLPKVLNLTELGIKAVSEAKLCSYLRLWPFFLGKDSDLPKDKLATRQQWKNRNLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIW5</accession>
    <name>A0A151MIW5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TBC domain-containing protein kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TBCK</name>
        <name evidence="13" type="ORF">Y1Q_0002077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction. Also involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the control of actin-cytoskeleton organization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006071">
        <property type="protein sequence ID" value="KYO24457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIW5"/>
    <dbReference type="STRING" id="8496.A0A151MIW5"/>
    <dbReference type="eggNOG" id="KOG1093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000015">
        <property type="entry name" value="TBC domain-containing protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000332">
        <property type="entry name" value="TBC domain-containing protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000018">
        <property type="entry name" value="TBC domain-containing protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000012">
        <property type="entry name" value="TBC domain-containing protein kinase-like protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF87">
        <property type="entry name" value="TBC1 DOMAIN CONTAINING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="11">
        <location>
            <begin position="458"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="782"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO24457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="885" mass="99630" checksum="F370D13A1C7A38F7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK32</accession>
    <name>A0A151MK32_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor subfamily 2 group C member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NR2C2</name>
        <name evidence="14" type="ORF">Y1Q_0023756</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059572000.1">
        <property type="nucleotide sequence ID" value="XM_059716017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK32"/>
    <dbReference type="STRING" id="8496.A0A151MK32"/>
    <dbReference type="GeneID" id="102567450"/>
    <dbReference type="KEGG" id="amj:102567450"/>
    <dbReference type="CTD" id="7182"/>
    <dbReference type="eggNOG" id="KOG3575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10024684at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06967">
        <property type="entry name" value="NR_DBD_TR2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06952">
        <property type="entry name" value="NR_LBD_TR2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000012">
        <property type="entry name" value="Nuclear receptor subfamily 2 group C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000015">
        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048245">
        <property type="entry name" value="NR2C1/2-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048246">
        <property type="entry name" value="NR2C1/2-like_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="147"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="374"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO24884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="629" mass="69051" checksum="7AE06F3866B44C30" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK41</accession>
    <name>A0A151MK41_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLIT-ROBO Rho GTPase-activating protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rho GTPase-activating protein 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">WAVE-associated Rac GTPase-activating protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0023774</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Homodimer. Forms a heterooligomer with SRGAP1 and SRGAP2 through its F-BAR domain. Interacts with WASF1. Probably interacts with ROBO1. Interacts with FASLG.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK41"/>
    <dbReference type="STRING" id="8496.A0A151MK41"/>
    <dbReference type="eggNOG" id="KOG3565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5981864at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07684">
        <property type="entry name" value="F-BAR_srGAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11955">
        <property type="entry name" value="SH3_srGAP1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000013">
        <property type="entry name" value="SLIT-ROBO Rho GTPase activating protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000020">
        <property type="entry name" value="SLIT-ROBO Rho GTPase activating protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000005">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035648">
        <property type="entry name" value="srGAP1/2/3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049581">
        <property type="entry name" value="SrGAP3_F-BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="13">
        <location>
            <begin position="506"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="744"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="809"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="860"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="926"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1047"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1061"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO24905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1100" mass="124672" checksum="3D2A05DD0C9968BB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ML40</accession>
    <name>A0A151ML40_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Myosin tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0016253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005904">
        <property type="protein sequence ID" value="KYO25242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ML40"/>
    <dbReference type="STRING" id="8496.A0A151ML40"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000003">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000013">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000002">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000003">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000007">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF79">
        <property type="entry name" value="MYOSIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="13">
        <location>
            <begin position="1"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO25242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="702" mass="81294" checksum="B61581CB9ED35C43" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ML49</accession>
    <name>A0A151ML49_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0014877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005883">
        <property type="protein sequence ID" value="KYO25252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ML49"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018731412" evidence="7">
        <location>
            <begin position="19"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="328"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO25252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="514" mass="58081" checksum="D1AC496E50B1B564" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLV4</accession>
    <name>A0A151MLV4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 653</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZNF653</name>
        <name evidence="10" type="ORF">Y1Q_0018068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005762">
        <property type="protein sequence ID" value="KYO25502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLV4"/>
    <dbReference type="STRING" id="8496.A0A151MLV4"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000183">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000685">
        <property type="entry name" value="Zinc finger protein 653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056438">
        <property type="entry name" value="Znf-C2H2_CTCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23611">
        <property type="entry name" value="zf-C2H2_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO25502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="11362" checksum="3CCFC73322763C14" modified="2016-06-08" version="1">MSVTGVREFTCETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHRGELHYPFPCELCGKRFERLDSVKFHKLKSHPEPKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMI6</accession>
    <name>A0A151MMI6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein 420-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0019566</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005690">
        <property type="protein sequence ID" value="KYO25649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMI6"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001532">
        <property type="entry name" value="Zinc finger protein 483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001343">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000873">
        <property type="entry name" value="Zinc finger protein 841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB-related" evidence="15">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO25649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="84258" checksum="9644B89F1364BA16" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMN6</accession>
    <name>A0A151MMN6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="9">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GALE</name>
        <name evidence="11" type="ORF">Y1Q_0023597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 9">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="9"/>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014461228.1">
        <property type="nucleotide sequence ID" value="XM_014605742.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMN6"/>
    <dbReference type="STRING" id="8496.A0A151MMN6"/>
    <dbReference type="GeneID" id="102572330"/>
    <dbReference type="KEGG" id="amj:102572330"/>
    <dbReference type="CTD" id="2582"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="10">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO25784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="347" mass="38050" checksum="B58C26AAB9B7EF9D" modified="2016-06-08" version="1">MAEKVLVTGGAGYIGSHCVLELVAAGYVPVVIDNFHNAIRGEGGLPESLRRVQGLVGREILFEELDVLDEAALRGLFGKHRFSAVMHLAGLKAVGESVQQPLEYYKVNLTGTIRLLEAMNAHGVRNIVFSSSATVYGDPAYLPLDEKHPVGGCTNPYGKSKYFIEEMIRDLCKAEKGWNAVLLRYFNPIGAHESGDIGEDPQGIPNNLMPYVAQVAVGRREFLSVFGNDYDTVDGTGVRDYIHIVDLAKGHIAALKKLKENCGCKIYNLGTGTGYSVLQMVKAMEKASGREIKYKIVARREGDVATCYADPGLAAQELGWKAAFGLNKMCEDLWRWQMQNPMGFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMQ4</accession>
    <name>A0A151MMQ4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Syncoilin isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SYNC-1</name>
        <name evidence="6" type="ORF">Y1Q_0023632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMQ4"/>
    <dbReference type="STRING" id="8496.A0A151MMQ4"/>
    <dbReference type="GeneID" id="102559355"/>
    <dbReference type="KEGG" id="amj:102559355"/>
    <dbReference type="CTD" id="81493"/>
    <dbReference type="eggNOG" id="ENOG502RKZJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8842296at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027702">
        <property type="entry name" value="Syncoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47147">
        <property type="entry name" value="SYNCOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47147:SF1">
        <property type="entry name" value="SYNCOILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="75"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="254"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO25827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="380" mass="44670" checksum="625F9498A0FC8261" modified="2016-06-08" version="1">MSSPEQEELVSWRERDLMADSEPPLESPSDDASAVLDPEEDVTETPLYLEVEADPLELPVDVASSLLEPDAAESQSLTIEEVGERFQECIDAVEQLEKERDNLIQELTLLREPVLQEIRQAHEEILTAYKLLAKVELERDNLRDEIRQIKQKLFKVTRECVACQYQLENRRHDMAQYAAYRDELESRVSQLSEELSQLKETCEKQKEQFRQQLEAPQSRRDSHYLQESRRLSMEFENFVAGSRRGLEEHYEPQLARLVERREASAKALQKMQGEIQGLKEVLRPLQGEASKMRLQNRKLEEQILLIKQKRDEEVLQYREQVEELEERLRELKNGVQLQQHKNQELEELRTSLHQELSVYKGCLEIYGQFCKSEEKADQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMQ9</accession>
    <name>A0A151MMQ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0023633</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMQ9"/>
    <dbReference type="SMR" id="A0A151MMQ9"/>
    <dbReference type="STRING" id="8496.A0A151MMQ9"/>
    <dbReference type="KEGG" id="amj:102559581"/>
    <dbReference type="eggNOG" id="KOG0264">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MMQ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000021">
        <property type="entry name" value="histone-binding protein RBBP4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="12">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO25828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="425" mass="47656" checksum="B71E2D55A444C360" modified="2016-06-08" version="1">MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNZ8</accession>
    <name>A0A151MNZ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNZ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10341" checksum="E89EC4EB198D7C7C" modified="2016-06-08" version="1">MPLPKSGTQLQYKASKWDKKSQVMRKDPGSFACLVQEAETQLDVMLGLEPTIKQNKPEKSYLDTWLFGSFSIELHLPSLKLIQNAITMIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MP47</accession>
    <name>A0A151MP47_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">B3GNT8</name>
        <name evidence="15" type="ORF">Y1Q_0017003</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03005571">
        <property type="protein sequence ID" value="KYO26308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059574708.1">
        <property type="nucleotide sequence ID" value="XM_059718725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MP47"/>
    <dbReference type="STRING" id="8496.A0A151MP47"/>
    <dbReference type="GeneID" id="102566608"/>
    <dbReference type="KEGG" id="amj:102566608"/>
    <dbReference type="CTD" id="374907"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5957813at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016262">
        <property type="term" value="F:protein N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030311">
        <property type="term" value="P:poly-N-acetyllactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF87">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585322" description="Hexosyltransferase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO26308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="389" mass="41718" checksum="E28FFFB6B01028BF" modified="2016-06-08" version="1">MSRMRYHKCLTVALALATLLCLDAYIRWSPLGEPDPVPLPLATTPAPPTTPAPPLPLHHSLQILANMVPRADAYWNRQLHQRLEELGGGNGTSASAGTAASLGVPDWAAYPEPLQRFVSHGARRHYPLLLEPSRPCPPDGPFLLLAIKSAPGAFAERQAVRQSWGQAGAGVRTVFLLGAPDGDGDTPDISGLVAWESRAHGDVLAWGFQDAFFNLTLKGLLFLGWAGAHCPGARFVLLGDDDVFVNTPRLLQLLAGLGPGPVYAGHVMAGAWPVRAPGSKYYVPESFYAGPYPAYAGGGGYVFSGALLGPLQVLAGLLPPFPIDDVFAGLCFRALGVAARPHPGFRTFDIAPSDRASPCAHRALLLVHRRQPPETLRLWRQVRDPQLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPL3</accession>
    <name>A0A151MPL3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPL3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF4">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="14444" checksum="5EA85928E07B370C" modified="2016-06-08" version="1">MVTDNGANMVKAVYDASFVVIHCVAHIFHLIVRDTLEGDRAATDGAVTNTQLISKYMKMLGYFHQSIKVGKMLWEKQAELSIPQHNIMQDVETQWNSTYLMPKRLVEQQKAIHEMALLRETDQQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQ92</accession>
    <name>A0A151MQ92_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and SOCS box protein 4 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ASB4</name>
        <name evidence="6" type="ORF">Y1Q_0019158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQ92"/>
    <dbReference type="STRING" id="8496.A0A151MQ92"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03723">
        <property type="entry name" value="SOCS_ASB4_ASB18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000271">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF86">
        <property type="entry name" value="GA-BINDING PROTEIN SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO26682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="418" mass="47519" checksum="7A5C0923A5046CFF" modified="2016-06-08" version="1">MWARLRWRRQEPGGSKYKAPKELRLFTETDLKQIDVDTVFEVEDENLILASYKQGYWLPGYKLKTSWATGLHLAVMYGHMESLMVLLNHKATINCRPNGKAAIHVACEVANVECLKILCKHGAKINCFSMSGHAPLHFCTTKTSVPCAQQLIWRGANVNIKTNNQDEETPLHTVARFGIPELVAFYVEQGANVDAINAHMETPLAYAAYWALQYKEQIYSTEHHLICRMLLDYKAEVNSRDEDFKSPLHKAAWNCDHVLLNMLLEAGAEANIMDVNGCAPIQYVLKVTPVRPAAQPEICYQLLLNHGAARIYPLQFHKVLQACHSHPKAVEVVINSYEYIKSTSKWKAAIPDDVFERHQDFYNSLFNVCSNSPRSLMHLCRCAIRGTLFKRCHRGVPLLTIPPSLKKYLLLEPEGIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQA4</accession>
    <name>A0A151MQA4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Desmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DESMB</name>
        <name evidence="9" type="ORF">Y1Q_0019091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQA4"/>
    <dbReference type="STRING" id="8496.A0A151MQA4"/>
    <dbReference type="eggNOG" id="KOG0977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006821">
        <property type="entry name" value="Intermed_filament_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050405">
        <property type="entry name" value="Intermediate_filament"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652">
        <property type="entry name" value="GLIAL FIBRILLARY ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652:SF5">
        <property type="entry name" value="VIMENTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04732">
        <property type="entry name" value="Filament_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="25"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="217"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO26599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="388" mass="45548" checksum="79832751FDDCBCD5" modified="2016-06-08" version="1">MLHDTVDFSLADAINTEFKANRTNEKVELQELNDRFANYIDKVRFLEQQNKILVAELEQLKGKGTSRLGDLYEEEMRELRRQVDELTNDKARVEVERDNLADDIMKLREKLQDEMEQREEAETTLQSFRQDVDNASLARLDLERKVESLQEEIVFLKKLHDEEIRELQAQIQDHHIQIDMDVSKPDLTAALRDVRQQYESVAAKNLHEAEEWYKSKFADLSEAANRNNDALRQAKQEANEYRRQIQSLTCEVDALKGTNESLERQMREIEENFNAEAANYQDTIARLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRINMPIPTFASLNLRETNIESQPMVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQM9</accession>
    <name>A0A151MQM9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Homeobox protein Hox-A6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HOXA6</name>
        <name evidence="15" type="ORF">Y1Q_0019283</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006265424.1">
        <property type="nucleotide sequence ID" value="XM_006265362.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQM9"/>
    <dbReference type="STRING" id="8496.A0A151MQM9"/>
    <dbReference type="GeneID" id="102559003"/>
    <dbReference type="KEGG" id="amj:102559003"/>
    <dbReference type="CTD" id="3203"/>
    <dbReference type="eggNOG" id="KOG0489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MQM9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000879">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF14">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="151"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="153"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO26841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="231" mass="26594" checksum="1ACC52774A51BA9E" modified="2016-06-08" version="1">MSSYFVNPTFPGSLPNGQESFLGQIPLYPAGYDALRHFPASYGAANLQDKAYTSPCFYQQSNTVIACNRASYEYGASCFYSDKDLSSASPSGSGKQRGHGDYLHFSPEQQYKSDSVQSKILHDEGSDRKYSSPVYPWMQRMNSCAGTVYGTHGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQPSSEETEEKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTJ7</accession>
    <name>A0A151MTJ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="10">5.4.2.11</ecNumber>
            <ecNumber evidence="10">5.4.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PGAM1</name>
        <name evidence="11" type="ORF">Y1Q_0020174</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17765"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="EC" id="5.4.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="10"/>
    <dbReference type="EC" id="5.4.2.4" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03005086">
        <property type="protein sequence ID" value="KYO27798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014458218.1">
        <property type="nucleotide sequence ID" value="XM_014602732.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTJ7"/>
    <dbReference type="STRING" id="8496.A0A151MTJ7"/>
    <dbReference type="GeneID" id="106737416"/>
    <dbReference type="KEGG" id="amj:106737416"/>
    <dbReference type="CTD" id="5223"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004082">
        <property type="term" value="F:bisphosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000007">
        <property type="entry name" value="Phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO27798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="254" mass="28814" checksum="351AAE53EA28FAA8" modified="2016-06-08" version="1">MAAHRLVLLRHGESTWNLENRFSGWYDADLSPQGRLEAQRGGDALRDAGYEFDVCFTSVQKRAVRTLWLVLDAVDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDIPPPPMLPDHPFYAAISKDRRYADLTEDQLPTCESLKDTIARALPFWNEEIVPQIKEGKRVLVAAHGNSLRGIVKHLEGMSEEAIMELNLPTGIPMVYELDKNLKPVKPMQFLGDEETVRKAMEAVAAQGKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVT7</accession>
    <name>A0A151MVT7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004889">
        <property type="protein sequence ID" value="KYO28558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVT7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="135" mass="14704" checksum="567C00C38CC7D5A0" modified="2016-06-08" version="1">MGNRPDATTKKKRPLKEKTTQISKARQRRERDSNLKASLTSALQAARWEAEAVKRAPTSAKDSSPLISQGFLEYLTDGATEARRKKAEFTGELGVGAALLEFTSAELHPSWEVSAKYSATSTGKGSSARCFPQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWN1</accession>
    <name>A0A151MWN1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline-serine-threonine phosphatase-interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSTPIP2</name>
        <name evidence="12" type="ORF">Y1Q_0009715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to F-actin. May be involved in regulation of the actin cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449425.1">
        <property type="nucleotide sequence ID" value="XM_014593939.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWN1"/>
    <dbReference type="STRING" id="8496.A0A151MWN1"/>
    <dbReference type="GeneID" id="102557777"/>
    <dbReference type="KEGG" id="amj:102557777"/>
    <dbReference type="CTD" id="9050"/>
    <dbReference type="eggNOG" id="KOG2398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07672">
        <property type="entry name" value="F-BAR_PSTPIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000054">
        <property type="entry name" value="Proline-serine-threonine phosphatase interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042694">
        <property type="entry name" value="PSTPIP2_F-BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF9">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO28858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="333" mass="39381" checksum="4A7E2B2ABD1215AF" modified="2016-06-08" version="1">MKETLFKKNFWSTDLTSTAGYDIIIQHLNDGRKNCKEYEDFLKERAIIEEKYGKELINLSRKKPCGQTELNTLKKALEVFKQRIDSVGQSHIQLAQSFREEARKMEDFREKQKLHRKKIELIMEAIHKNRNLQYKKTVESKRLYEQRCRDKDEAEQAVHRSANLVTQKQQEKLFMKLAQAKSTLEDSDRAYQQNVNMLEKIREEWENEHIKACEFFETQECERISYFRNALWVHVNQLSQECVQSDEKYEEIRRSLEMCNIDKDIEFFVNYRKMGNMPPAPVVYENYYNTSRNATPVRNPPPGIGRRGPLPIPTSGPSDPDYATVDGYSLVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWX1</accession>
    <name>A0A151MWX1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Growth hormone receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Somatotropin receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GHR</name>
        <name evidence="20" type="ORF">Y1Q_0009860</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type I cytokine receptor family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWX1"/>
    <dbReference type="STRING" id="8496.A0A151MWX1"/>
    <dbReference type="eggNOG" id="KOG3555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000269">
        <property type="entry name" value="Growth hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000318">
        <property type="entry name" value="Growth hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025871">
        <property type="entry name" value="GHBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015152">
        <property type="entry name" value="Growth/epo_recpt_lig-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037:SF46">
        <property type="entry name" value="INTERLEUKIN 5 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09067">
        <property type="entry name" value="EpoR_lig-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12772">
        <property type="entry name" value="GHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO29051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="631" mass="70856" checksum="49341AEAC44307E2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXK4</accession>
    <name>A0A151MXK4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CUB and sushi domain-containing protein 3 isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CSMD3</name>
        <name evidence="7" type="ORF">Y1Q_0017938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MXK4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000001">
        <property type="entry name" value="CUB and sushi domain-containing protein 3 isoform X1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000002">
        <property type="entry name" value="CUB and Sushi multiple domains 3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000047">
        <property type="entry name" value="CUB and Sushi multiple domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000053">
        <property type="entry name" value="CUB and Sushi multiple domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF37">
        <property type="entry name" value="CUB AND SUSHI MULTIPLE DOMAINS 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="68"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="179"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="244"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="383"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="447"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
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            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="620"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
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            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
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            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="907"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="966"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1079"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1140"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1251"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1313"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
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            <end position="962"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1313"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO29291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1450" mass="159628" checksum="41B647DACF53AFC7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MY79</accession>
    <name>A0A151MY79_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MY79"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7613" checksum="48719775510357D1" modified="2016-06-08" version="1">MPVSWCSRWPKAGKAAFDLVSPFDCKYCLQHCTGQHSDLGHIGNLVTRSSQTETGSLGCDQMSAVVSDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZB7</accession>
    <name>A0A151MZB7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0016714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004457">
        <property type="protein sequence ID" value="KYO29913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZB7"/>
    <dbReference type="STRING" id="8496.A0A151MZB7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO29913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10607" checksum="5D0E1F4ED551940F" modified="2016-06-08" version="1">MAKDVSDIGRGAVLLQEHQETRHPVVYLSQKLIPQERNLSSIEKECLAIVWALNKLKPYLWGQQFTVLSDHAPLRWLQTMQNTNARLQRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N225</accession>
    <name>A0A151N225_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004153">
        <property type="protein sequence ID" value="KYO30808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N225"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7871" checksum="B8E85936FB98D5E1" modified="2016-06-08" version="1">MIAAGTCGASSRGDKPSRSNLHIVIRKSRPNSSLIYSGYTPRDILDYTEVTLELHQRHCLQNLACQWSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2C6</accession>
    <name>A0A151N2C6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Nucleosome-remodeling factor subunit BPTF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BPTF</name>
        <name evidence="19" type="ORF">Y1Q_0016369</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N2C6"/>
    <dbReference type="eggNOG" id="KOG1473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15559">
        <property type="entry name" value="PHD1_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000018">
        <property type="entry name" value="nucleosome-remodeling factor subunit BPTF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000036">
        <property type="entry name" value="nucleosome-remodeling factor subunit BPTF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000048">
        <property type="entry name" value="nucleosome-remodeling factor subunit BPTF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="2568"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="17">
        <location>
            <begin position="2645"/>
            <end position="2715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="191"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="924"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1059"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1237"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1636"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1707"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1882"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1956"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2071"/>
            <end position="2191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2520"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2342"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2485"/>
            <end position="2515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="951"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1249"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1716"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1883"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1956"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1981"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2071"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2088"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2109"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2142"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2181"/>
            <end position="2191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2737" mass="303897" checksum="53779804406138F6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N329</accession>
    <name>A0A151N329_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N329"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO31224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="133" mass="14988" checksum="8CA2174AE00B3B35" modified="2016-06-08" version="1">MRAPKARRKRRCLCDNRDAGKWEMLPESFAGPSQEATTYRQKDPPSQGQYFSGRGVARRAQGRRLRKAEGLKGTPRACLGQTKSQISCDHKNLIPGHCCPERKPVSVSHFRQCMEPPATLHCRNERKNGSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N402</accession>
    <name>A0A151N402_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein</fullName>
            <shortName evidence="6">Cnt-b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Centaurin-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0006118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endosome membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N402"/>
    <dbReference type="STRING" id="8496.A0A151N402"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000025">
        <property type="entry name" value="arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF407">
        <property type="entry name" value="ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO31556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="270" mass="31430" checksum="37CF78874AE53F2E" modified="2016-06-08" version="1">MTVDFEECIKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMIEAGKAYITTNKHFVTGVRDLSQQCKKDEMISECLDKFGDSLQEMINYHMILFDQAQRSVRQQLHNFVKDDVRKFKETKKQFDKVREDMEISLVKNAQAPRHKPHEVEEATGTLTITRKCFRHLALDYVLQINVLQAKKKFEILDAMLSFMQAQYTFFQQGYSLLHELDPYMKKLATELDQLVIDSAVEKREMEHKHALIQQRVSPGLRAGMRGPKRGHSFLSDREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N527</accession>
    <name>A0A151N527_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Y1Q_0012165</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72215"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72219"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004011">
        <property type="protein sequence ID" value="KYO31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N527"/>
    <dbReference type="STRING" id="8496.A0A151N527"/>
    <dbReference type="eggNOG" id="KOG1172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000002">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003024">
        <property type="entry name" value="Na/HCO3_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF10">
        <property type="entry name" value="ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01232">
        <property type="entry name" value="NAHCO3TRSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="922"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="973"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="18">
        <location>
            <begin position="126"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="17">
        <location>
            <begin position="460"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1030"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1080"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1097" mass="123802" checksum="8F78F8FF3D9C5FD2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5Q2</accession>
    <name>A0A151N5Q2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5Q2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="92" mass="10485" checksum="DF9FCA64FDC49B05" modified="2016-06-08" version="1">MHHPRTQSVKDSLSLGNDFASTLPFITPEKYAKEAGKERNDASTQSIKEIEQPNWEMESQQFCHLFNGMVLREAAMDDFGVLERPCKLLLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7N2</accession>
    <name>A0A151N7N2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0009382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7N2"/>
    <dbReference type="eggNOG" id="ENOG502TB78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585816" evidence="2">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO32796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="113" mass="12879" checksum="E084AD8E03BE8087" modified="2016-06-08" version="1">MDIYSILFFLLSILMTGCCQTGGNEFQESQKLRQNLIIAAMSVFLVMSLLLILGCSFIHYKLVTKDDTAVKEEVKSVAIKTHSHRIETRIVLSPSQLVKRKYLLLKTSQMIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7P6</accession>
    <name>A0A151N7P6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein unc-45 homolog B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0013055</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003911">
        <property type="protein sequence ID" value="KYO32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7P6"/>
    <dbReference type="STRING" id="8496.A0A151N7P6"/>
    <dbReference type="eggNOG" id="KOG4151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000043">
        <property type="entry name" value="Unc-45 myosin chaperone B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000025">
        <property type="entry name" value="Unc-45 myosin chaperone B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF2">
        <property type="entry name" value="PROTEIN UNC-45 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="13">
        <location>
            <begin position="359"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="860" mass="96299" checksum="F09B1B8FAA8AFB67" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N822</accession>
    <name>A0A151N822_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Allantoate amidinohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ALLC</name>
        <name evidence="4" type="ORF">Y1Q_0011264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003826">
        <property type="protein sequence ID" value="KYO32936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N822"/>
    <dbReference type="STRING" id="8496.A0A151N822"/>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000077">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000085">
        <property type="entry name" value="probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="77"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="272"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO32936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="432" mass="48475" checksum="C44B0A80F416FE86" modified="2016-06-08" version="1">MCKCVHTHMWPACSQDGWWEQLQLLDAADAGVEDIRTGSQTSASAFTGKMAAHLKEEKTQVLPDFLNLNDLACKTMGGKVLFATDDFFAPADNLLKKQNPEFKVDTFTAYGKWMDGWETRRKRTPGHDWCIIQLGVPGTIHGFEVNTSFFAGNCAPRISVQAACLKQVEIPELWPRGDRIGTAASDEEFEAVKKMKSEEWNFLVPMTELKPGSLDISQSYFSANSKQRWTHVRFNIYPDGGIARFKVFGIIQKDWSASGLNDLHDLVAMANGGVCVGFSSTQLGHPQNILWPGKATSMKDGWETARRMDRPPVVKVDDKGILLIPGHEWAVFRLAHPGIITHIEIDTTHFKGNFPDTCQVEACVLNAEEEKECLTQKWNLKKGLKWIPLLSVAKLKPNKRHFFDGTVMQMQDAITHVRLIICPDGGTRIIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N932</accession>
    <name>A0A151N932_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitogen-activated protein kinase 13</fullName>
            <ecNumber evidence="5">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="37" type="primary">MAPK13</name>
        <name evidence="37" type="ORF">Y1Q_0014901</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with MAPK8IP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="37">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N932"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05512">
        <property type="entry name" value="Bromo_brd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15572">
        <property type="entry name" value="PHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20158">
        <property type="entry name" value="PWWP_BRPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07879">
        <property type="entry name" value="STKc_p38delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000007">
        <property type="entry name" value="Bromodomain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000170">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000769">
        <property type="entry name" value="Mitogen-activated protein kinase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038785">
        <property type="entry name" value="MAPK13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF19">
        <property type="entry name" value="BROMODOMAIN AND PHD FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21 27" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="24" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="30" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14 37" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0346">Stress response</keyword>
    <keyword evidence="22" id="KW-0804">Transcription</keyword>
    <keyword evidence="19" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 28" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="32">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="34">
        <location>
            <begin position="585"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="36">
        <location>
            <begin position="639"/>
            <end position="760"/>
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            <end position="1028"/>
        </location>
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        <location>
            <begin position="1417"/>
            <end position="1500"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="447"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="760"/>
            <end position="805"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1134"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1286"/>
            <end position="1358"/>
        </location>
    </feature>
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        <location>
            <begin position="1370"/>
            <end position="1393"/>
        </location>
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        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
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        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="31">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
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        <location>
            <begin position="1134"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="1148"/>
            <end position="1161"/>
        </location>
    </feature>
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            <end position="1228"/>
        </location>
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        <location>
            <begin position="1297"/>
            <end position="1306"/>
        </location>
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            <begin position="1320"/>
            <end position="1330"/>
        </location>
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        <location>
            <position position="55"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
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    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
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    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
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    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
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    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="KYO33099.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1546" mass="175943" checksum="8BC1E65045CF67FF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9Q3</accession>
    <name>A0A151N9Q3_ALLMI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">Y1Q_0016973</name>
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    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
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                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">KSC_2009_1</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A151NBJ1_ALLMI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
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                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
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                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
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                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003593">
        <property type="protein sequence ID" value="KYO34137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S49V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Axonemal_MT_stabilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404:SF1">
        <property type="entry name" value="HCG1796489"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <dbReference type="EMBL" id="KYO34137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="236" mass="26570" checksum="DD1D1C51245EF859" modified="2016-06-08" version="1">MKGGHWHHRQDWHLTSSGVGLEYQPPLPFLPPAAQSTLHQPLPLASEQLWKEGDTKHLATTTVLCHKVKTHGGVLSQPHHPIPPPHWQVHFNKDLQDKLHLHTWQFPLAAAYLVSEMQECFPGWPSLAPNGARLPGAQVPCLVDHHCDGPSKQVVPTTQNPALAGRLFYLQEEGALHQLEPYASVPARDFRPFSQYGIPWHRAPDPWVPWRGARRGLEPGRVFARTPTSCLGWARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NC91</accession>
    <name>A0A151NC91_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003458">
        <property type="protein sequence ID" value="KYO34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NC91"/>
    <dbReference type="STRING" id="8496.A0A151NC91"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="137" mass="15160" checksum="691B2CE14FA761BF" modified="2016-06-08" version="1">MEVSEAEGMSRLYLQPVDVISKKHSYSGQVGLPHVIPAAPARSVGAGTYTALSSLPLGHSTYREQYVFLYRPARICLLDAFTYPDLAPGRPDVFACEPHIVRLHLPSRGCDITTGIEDMWNGKTEIKVDNRDQGKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCM0</accession>
    <name>A0A151NCM0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Copper-transporting ATPase 2</fullName>
            <ecNumber evidence="4">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Copper pump 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Y1Q_0007630</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Cu(+)(in) + ATP + H2O = Cu(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Monomer. Interacts with COMMD1/MURR1. Interacts with DCTN4, in a copper-dependent manner. Interacts with ATOX1. Interacts (via C-terminus) with ZBTB16/PLZF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03003532">
        <property type="protein sequence ID" value="KYO34359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCM0"/>
    <dbReference type="STRING" id="8496.A0A151NCM0"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060003">
        <property type="term" value="P:copper ion export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000015">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000022">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000092">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF29">
        <property type="entry name" value="COPPER-TRANSPORTING ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0187">Copper transport</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="947"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="25">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="25">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO34359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1037" mass="112016" checksum="0D5EC42B0D64218E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDR0</accession>
    <name>A0A151NDR0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Beta-1,4-galactosyltransferase</fullName>
            <shortName evidence="17">Beta-1,4-GalTase</shortName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Y1Q_0018499</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1-&gt;4)-N-acetyl-D-glucosamine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17745"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60152"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="2.4.1.90"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:17746"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="AKHW03003238">
        <property type="protein sequence ID" value="KYO34926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDR0"/>
    <dbReference type="STRING" id="8496.A0A151NDR0"/>
    <dbReference type="KEGG" id="amj:102572436"/>
    <dbReference type="eggNOG" id="KOG3916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NDR0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003945">
        <property type="term" value="F:N-acetyllactosamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000028">
        <property type="entry name" value="beta-1,4-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF34">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14 17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="19">
        <location>
            <begin position="84"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="18">
        <location>
            <begin position="223"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO34926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="354" mass="39213" checksum="24088E023E3E1F5F" modified="2016-06-08" version="1">MVPGRARALLVLLGVQLVLLGLLYGEGSRRRLAYLLGLLHRGGAAGGPPGGVGLGGVPLLPGNTSVPPGNLSRPVPPLGDLPYCPRQSPLLVGPLHVSLAPGRALAGLERANAAAGVEPGGRWRPPSCLARSRTAVLVPHRGREPHLRLLLQHLHPLLQRQQLRYGLYVVHQAGNETFNRAKLLNVGFKEAMKDEDWDCVYFHDVDLLPEDDRNLYVCDRHPRHAAAAMDKFGYKLPYKTYFGGVSALTPEQYMKMNGFPNNYWGWGGEDDDIAIRVALSGMVISRPALAVGRYRMIKHGHDKGNEQNPKRFHLLARTRRTWRLDGMNTLEYRLIAKELRPLYTNLTVDIGRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEL1</accession>
    <name>A0A151NEL1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="33">Phospholipase ABHD3</fullName>
            <ecNumber evidence="3">3.1.1.32</ecNumber>
            <ecNumber evidence="4">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="34">Abhydrolase domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="38" type="primary">ABHD3</name>
        <name evidence="38" type="ORF">Y1Q_0007843</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="38 39" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="32">Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54456"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:45240"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:54457"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54404"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:45240"/>
            <dbReference type="ChEBI" id="CHEBI:131738"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:54405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:44811"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:78208"/>
            <dbReference type="ChEBI" id="CHEBI:138269"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 5-oxopentanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40483"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16120"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77890"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40484"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 9-oxononanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61042"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77812"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = glutarate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41159"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77756"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:41160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:78207"/>
            <dbReference type="ChEBI" id="CHEBI:78208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:75220"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:54409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = hexanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54464"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138212"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = nonanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54472"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32361"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54473"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138213"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = pentanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31011"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54400"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76085"/>
            <dbReference type="ChEBI" id="CHEBI:86162"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76079"/>
            <dbReference type="ChEBI" id="CHEBI:86102"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
            <dbReference type="ChEBI" id="CHEBI:86094"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
            <dbReference type="ChEBI" id="CHEBI:86094"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:54389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:18690"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="38">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="3"/>
    <dbReference type="EC" id="3.1.1.4" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEL1"/>
    <dbReference type="GeneID" id="102567219"/>
    <dbReference type="KEGG" id="amj:102567219"/>
    <dbReference type="CTD" id="171586"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000079">
        <property type="entry name" value="Abhydrolase domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF50">
        <property type="entry name" value="PHOSPHOLIPASE ABHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 36" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="39" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 36" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 36" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="36">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="37">
        <location>
            <begin position="135"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="35">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="35">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="35">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00050276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00051705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00052747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00052808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00052894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00059841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00071303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00082158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EMBL" id="KYO35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="406" mass="45488" checksum="09242DF8DC31C407" modified="2016-06-08" version="1">MSLPVLARELSHYLDSRVRGGLAGSGMGWSLVLGFGVAYAACYLSSIAKKPQLVAGSKSFCCFLKKYCPVVTETYYPTIWCWEGRAQTLLRPFITSKPQVQYRNELIKTTDGGQISLDWFDNNDSVRYPDDSTRPTILVLPGLTGTSKESYVLHMIQQSKKLGYRCVVFNNRGTAGEDLLTPRTYCAANTEDLEAVIHHVHNLHASAPLLAAGVSMGGMLLLNYLGKTGKETPLMAAAVFSPGWNIFASVESLEKRLNWFLFNYYLTTCLQSSISRHRKMLEKLFDLDLVMKAKTIREFDKQFTSVMFGYPTIEDYYEDASPYHKLKSVGIPLLCLNSVDDVFSPGHAVPVEMAKQNPNVAIVLTSCGGHIGFLEGMWPRNCTYMDRVFKQFVRAIFEHGKQIISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGM0</accession>
    <name>A0A151NGM0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
            <ecNumber evidence="5">5.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20 21">Delta(3),Delta(2)-enoyl-CoA isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Dodecenoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ECI1</name>
        <name evidence="25" type="ORF">Y1Q_0009296</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45748"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:85415"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:45749"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:45229"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.8" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03003035">
        <property type="protein sequence ID" value="KYO35952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGM0"/>
    <dbReference type="STRING" id="8496.A0A151NGM0"/>
    <dbReference type="eggNOG" id="KOG1683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 25" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO35952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="291" mass="32473" checksum="56B802E67DEA299E" modified="2016-06-08" version="1">MMILSRLLGCQEQLGFLHQSKEELTDSHPVVCNRNILVELEEGVGVAVMKMKSPPVNSLSLDFLTEFSISLEKLENDRGCRGVILTSAVPKIFSAGLDIKEMCGKSAEHYAEFWRAVQEMWLKLYKSNMVTIAAINGNCPAGGCLMAVSCDYRIMAENPKYSIGLNETQLGIVAPFWFKDTIANTIGHRATERSLQLGLLYSASDALKIGIVDELVPEEKVLNAAAATMSQWLAIPDYARQISKSMMRKPTLDRLLTHRESDIQNFVSFVTKDSIQKSLQTYMESLKQRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NH15</accession>
    <name>A0A151NH15_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lariat debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DBR1</name>
        <name evidence="15" type="ORF">Y1Q_0013138</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270504.1">
        <property type="nucleotide sequence ID" value="XM_006270442.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NH15"/>
    <dbReference type="STRING" id="8496.A0A151NH15"/>
    <dbReference type="GeneID" id="102576313"/>
    <dbReference type="KEGG" id="amj:102576313"/>
    <dbReference type="CTD" id="51163"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="235"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO36102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="538" mass="61259" checksum="1C1CA87BD74C1A7D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHF3</accession>
    <name>A0A151NHF3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centromere protein M</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CENPM</name>
        <name evidence="7" type="ORF">Y1Q_0024016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259959.2">
        <property type="nucleotide sequence ID" value="XM_006259897.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHF3"/>
    <dbReference type="STRING" id="8496.A0A151NHF3"/>
    <dbReference type="GeneID" id="102561521"/>
    <dbReference type="KEGG" id="amj:102561521"/>
    <dbReference type="CTD" id="79019"/>
    <dbReference type="eggNOG" id="ENOG502S17M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2386686at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NHF3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020987">
        <property type="entry name" value="Centromere_Cenp-M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34436">
        <property type="entry name" value="CENTROMERE PROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34436:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11111">
        <property type="entry name" value="CENP-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO36228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="177" mass="19700" checksum="FAEA1E436A23ABB2" modified="2016-06-08" version="1">MSVVRPFDKLPVLNSAAILLVGTDEDLQRQLAQTILKEKKDFKISIHLATSLPLPAERDHIRPRIDLIVFMINVQSKYGFKNIEASLAHVDANFFLGKVCFLVTGVGRVNHCSVDMSAVRKLGDVYCSPLIFCELELEGIRISTAQRLLRMLQICAGHVPGVSALFFSSLMRSSNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIW4</accession>
    <name>A0A151NIW4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm-associated antigen 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SPAG5</name>
        <name evidence="2" type="ORF">Y1Q_0006768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002943">
        <property type="protein sequence ID" value="KYO36751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIW4"/>
    <dbReference type="STRING" id="8496.A0A151NIW4"/>
    <dbReference type="KEGG" id="amj:102575704"/>
    <dbReference type="eggNOG" id="ENOG502RW0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5972338at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051988">
        <property type="term" value="P:regulation of attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028728">
        <property type="entry name" value="Astrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15347">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15347:SF1">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="435"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="662" mass="74008" checksum="44B3A98DE98FB314" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIY8</accession>
    <name>A0A151NIY8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCN family member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cellular communication network factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein CYR61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CYR61</name>
        <name evidence="16" type="ORF">Y1Q_0020824</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIY8"/>
    <dbReference type="STRING" id="8496.A0A151NIY8"/>
    <dbReference type="GeneID" id="102557985"/>
    <dbReference type="KEGG" id="amj:102557985"/>
    <dbReference type="CTD" id="3491"/>
    <dbReference type="eggNOG" id="ENOG502QQQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="365605at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009891">
        <property type="term" value="P:positive regulation of biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010556">
        <property type="term" value="P:regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000026">
        <property type="term" value="P:regulation of multicellular organismal development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000015">
        <property type="entry name" value="CYR61 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000038">
        <property type="entry name" value="CYR61 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050941">
        <property type="entry name" value="CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012395">
        <property type="entry name" value="IGFBP_CNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017891">
        <property type="entry name" value="Insulin_GF-bd_Cys-rich_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043973">
        <property type="entry name" value="TSP1_CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348:SF18">
        <property type="entry name" value="CCN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348">
        <property type="entry name" value="CONNECTIVE TISSUE GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19035">
        <property type="entry name" value="TSP1_CCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036495">
        <property type="entry name" value="IGFBP_rP_CNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00222">
        <property type="entry name" value="IGFBP_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586101" description="CCN family member 1" evidence="12">
        <location>
            <begin position="24"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="14">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="13">
        <location>
            <begin position="280"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO36771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="374" mass="41060" checksum="961C42ED29314442" modified="2016-06-08" version="1">MSCQGRSLVRLAALLCLCRLALSTCPAVCQCPLQVPKCAPGVGLVLDGCGCCKVCAKQLNEDCSKSQPCDHTKGLECNFGASPTALKGICRAQSEGRPCEYNSKIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPSPRLVKVPGQCCEEWMCDESKDGLEDLEGFFSKELGLDASEGELTRNNELIAIVKGGLKMLPVFGSEPHSQTFESPKCIVQTTSWSQCSKTCGTGLSTRVTNDNPDCKLVKESRICEVRPCGQSSYGSLKKGKKCTKTKKSQSPVKFTYAGCSSVKKYRPKYCGSCVDGRCCTPQQTRTIKIRFRCDDGETFTKNIMMIQSCRCNYNCPHANEAYPYYRLFNDIHKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK02</accession>
    <name>A0A151NK02_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proline-rich transmembrane protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PRRT4</name>
        <name evidence="10" type="ORF">Y1Q_0016893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002826">
        <property type="protein sequence ID" value="KYO37121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK02"/>
    <dbReference type="STRING" id="8496.A0A151NK02"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052836">
        <property type="entry name" value="PRRT_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578:SF6">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586131" evidence="8">
        <location>
            <begin position="23"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="9">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO37121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="482" mass="48918" checksum="2D2E0CEAFA919B52" modified="2016-06-08" version="1">MAERGAMWALLALACLSPPGSAETPRPLSPDVGTMAPGALLRAPGTASALPARSEDPVLSLNLGLNFKIKVRSQGSYRPAVPSAEPPPPDPAPPGLWTELPPGSGWLGADDPEDGAGGWDSSEALEPTAQLWAAARAVPRGAGLATPAGAGRERSKELEFKIDIDLTAGLDQERGAPPTSLLRQQAPGTRWRYPLLPSLRAGISEIASQLGASGFFSPTLAPDGHLGLEGNSTTGAWDLAPDGSPTPARATEPGLQPSGHSPSPGSAGAMAGDPLETPEPCSSPEPPAAPASPPLLVGLHADWNTALAAWGPAWEAHVYGAGALFGLLALLALLGLAGLPFRLPLDGGDPTADFRPPSPIDLGRSIAEALCSSPSLFQPALGTPPVPETPGVWPAGGSRCSTPRYGLSRAGSCQALCSSPEAPASPARDPGPFRGLAGMGDARCSPSPPGGPYRPLPPPSLESLPRGCQSDQLSVGSDTIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKK7</accession>
    <name>A0A151NKK7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kremen protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">KREMEN1</name>
        <name evidence="12" type="ORF">Y1Q_0013184</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002750">
        <property type="protein sequence ID" value="KYO37328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKK7"/>
    <dbReference type="STRING" id="8496.A0A151NKK7"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF13">
        <property type="entry name" value="KREMEN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="11">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="125"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO37328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="501" mass="54906" checksum="E3A616DFFA2F3D27" modified="2016-06-08" version="1">MAYEGIIIQEHEDGVYWKYCEIPSCRMPGNLGCYKDHGNPPPLTGTSETSNKLTIQTCISFCRSQQFKFAGMESGYACFCGSNPDYWRYGEAVSTECNSVCFGDHTQPCGGDGRVILFDTLIGACGGNYTAPTSVIYSPDFPDVYGTGRVCYWTIQVPGASQIHFSFALFDIKDSADMVEVLDGYTYHVLARFDSRNQPPLSFNVSLDSVILYFFSDQINQAQGFAVRYTATKETVQQDKAPVNLTLTEVITEQANLSISAVRSSKILYVITTSPSHAPGTMPEWTVYGLTALLILSVTAILAKILLHITMKSHQVPSAAGREDSYRATRASEIWSIFYEPSTSISIFKKKLNIGETALFQEALETLAPVSLSTSDCSELSQKLENPGGFLHELAGVCKTTLCAIAKRLFYGIQPPGLPEKPPLEKRASRPTPSAKSCLERAQCSCGSTQLSLGSLPMCRPDKIPVRKIIQLKSCRSEGKTPGQGFPIAGGFCEQQLTRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKQ8</accession>
    <name>A0A151NKQ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKQ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="86" mass="9835" checksum="C114645686DB6924" modified="2016-06-08" version="1">MFENVMLYSQHKQDSPMHPLLLADSTLLHCSNKIRLTSFSGEDPCFPPVSNSLKYKTGITYHKKIIHSTPNQDNHFNHAPNTQQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLL9</accession>
    <name>A0A151NLL9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002623">
        <property type="protein sequence ID" value="KYO37640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLL9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="117" mass="13695" checksum="A5E33C5E2A0F280D" modified="2016-06-08" version="1">MQDCTILLQQLVVMWQNWLEDLRAWWAEDVAHEVTCDQADHELWAELLPLDQEWLQLPQEQNTILGRAVHAMDDDHWVLDIILGSVNLTLQNFKIQFCLAYCKSTAVFYRTGIQVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NN91</accession>
    <name>A0A151NN91_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NN91"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12000" checksum="C1511CBFD4DA7A8F" modified="2016-06-08" version="1">MKLATPGIYCYIANQFSIGKSVAGEAIWEACGVIQDILANHFIHLINPQNVITDFSCMGFPTCVSAVDGIYIPTLCPTQASQAFNNCRGFSSIILQGIADRQGQFTCIFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNA4</accession>
    <name>A0A151NNA4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein CDX-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDX4L</name>
        <name evidence="10" type="ORF">Y1Q_0015584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Caudal homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNA4"/>
    <dbReference type="STRING" id="8496.A0A151NNA4"/>
    <dbReference type="GeneID" id="102561231"/>
    <dbReference type="KEGG" id="amj:102561231"/>
    <dbReference type="eggNOG" id="KOG0848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009948">
        <property type="term" value="P:anterior/posterior axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000089">
        <property type="entry name" value="Caudal type homeobox 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006820">
        <property type="entry name" value="Caudal_activation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047152">
        <property type="entry name" value="Caudal_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332:SF15">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04731">
        <property type="entry name" value="Caudal_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO38322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="277" mass="31220" checksum="9B420EC3ABEAFB0C" modified="2016-06-08" version="1">MYVGYLLDKEASMYPGSARCNNNNLPVQNFVSTPPYSDYMGYHHVPSMDNHGQTSGTWGSHYGPQREDWNAYGPGPSSTVTAAQINGSSPGQVSYSSTDYNSLHPTGSGVLPPVDTINTEQISPNPQRHSSYEWMRKTVQSTSTGKTRTREKYRVVYTDHQRLELEKEFHYNRYITIRRKSELAANLRLSERQVKIWFQNRRAKERKLMKKKMTHFDGSNLSSMQSDSGSVSPMPVPDPQTHSEMSNSLFPPPPPPPPLSMNGLQHNGNLQQVVASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPB5</accession>
    <name>A0A151NPB5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DNMT3B</name>
        <name evidence="18" type="ORF">Y1Q_0012822</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-cysteinyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13682"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03002452">
        <property type="protein sequence ID" value="KYO38550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPB5"/>
    <dbReference type="STRING" id="8496.A0A151NPB5"/>
    <dbReference type="eggNOG" id="ENOG502QR6U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11729">
        <property type="entry name" value="ADDz_Dnmt3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20154">
        <property type="entry name" value="PWWP_DNMT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000008">
        <property type="entry name" value="DNA (Cytosine-5)-methyltransferase 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000006">
        <property type="entry name" value="DNA (Cytosine-5)-methyltransferase 3B isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000011">
        <property type="entry name" value="DNA methyltransferase 3 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.50">
        <property type="entry name" value="PWWP, helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044108">
        <property type="entry name" value="ADD_DNMT3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054724">
        <property type="entry name" value="DNM3A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040552">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049554">
        <property type="entry name" value="DNMT3_ADD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF10">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17980">
        <property type="entry name" value="ADD_DNMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22855">
        <property type="entry name" value="DNM3A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21255">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="16">
        <location>
            <begin position="107"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="297"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO38550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="727" mass="82062" checksum="EDCE8900CFAFD1AC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPK7</accession>
    <name>A0A151NPK7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0015660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPK7"/>
    <dbReference type="STRING" id="8496.A0A151NPK7"/>
    <dbReference type="eggNOG" id="KOG3852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974:SF30">
        <property type="entry name" value="TERMINAL NUCLEOTIDYLTRANSFERASE 5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO38415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="255" mass="29583" checksum="1D7B2B6E55057D88" modified="2016-06-08" version="1">MVKVSTDHDRWSLISLSNNSGKNVELKFVNSLRRQFEFSVDSFQIILDSILNVYSDTDCELTEDSHPTVVAESMYGDFREAMDHLKYKLISTRNPEEIRGGGLLKYSNLLVRDFKPADEAEIKSLERYMCSRFFIDFPDVAEQQRKIESYLRNHFIGEEKSKYDYLMTLRGVVNESTVCLMGHERRQTLNMITILALKVLGEQNIIPNAANVTCYYQPAPYISDRNFSNYYIAHGQPPIIYQPYPFHIQMQSGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRT7</accession>
    <name>A0A151NRT7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adhesion G-protein coupled receptor D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">G-protein coupled receptor 133</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ADGRD1</name>
        <name evidence="22" type="ORF">Y1Q_0018652</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens. Also activated by methenolone drug. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with ESYT1; interaction takes place in absence of cytosolic calcium and inhibits the G protein-coupled receptor activity of ADGRD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRT7"/>
    <dbReference type="STRING" id="8496.A0A151NRT7"/>
    <dbReference type="KEGG" id="amj:102563360"/>
    <dbReference type="eggNOG" id="KOG4193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="347083at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014819">
        <property type="term" value="P:regulation of skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15256">
        <property type="entry name" value="7tmB2_GPR133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000073">
        <property type="entry name" value="Adhesion G-protein coupled receptor D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000104">
        <property type="entry name" value="adhesion G-protein coupled receptor D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000008">
        <property type="entry name" value="Adhesion G-protein coupled receptor D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF216">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586326" description="Adhesion G-protein coupled receptor D1" evidence="18">
        <location>
            <begin position="26"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="710"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="21">
        <location>
            <begin position="79"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="19">
        <location>
            <begin position="381"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="20">
        <location>
            <begin position="564"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO39571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="872" mass="96794" checksum="E8040F18358D2FBB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUF5</accession>
    <name>A0A151NUF5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUF5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="7904" checksum="6B4903A151714E12" modified="2016-06-08" version="1">MEEAVGPKHTAGQKGIRLLNDWGRDRIKKGASGICSPQSQAALSFSRPGHFCTWGKARLLKTPPQHSSSFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWJ6</accession>
    <name>A0A151NWJ6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Long-chain-fatty-acid--CoA ligase ACSBG2</fullName>
            <ecNumber evidence="10">6.2.1.15</ecNumber>
            <ecNumber evidence="11">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Acyl-CoA synthetase bubblegum family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Arachidonate--CoA ligase ACSBG2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ACSBG1</name>
        <name evidence="21" type="ORF">Y1Q_0011882</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33607"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33608"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33651"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33652"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="10"/>
    <dbReference type="EC" id="6.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWJ6"/>
    <dbReference type="STRING" id="8496.A0A151NWJ6"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05933">
        <property type="entry name" value="ACSBG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF101">
        <property type="entry name" value="ACYL-COA SYNTHETASE BUBBLEGUM FAMILY MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="127"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO41168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="751" mass="83508" checksum="6CB9CC97A2B49B74" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX02</accession>
    <name>A0A151NX02_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein CREG2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CREG2</name>
        <name evidence="7" type="ORF">Y1Q_0006226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CREG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX02"/>
    <dbReference type="STRING" id="8496.A0A151NX02"/>
    <dbReference type="eggNOG" id="KOG3374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000004">
        <property type="entry name" value="Cellular repressor of E1A-stimulated genes 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014631">
        <property type="entry name" value="CREG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF15">
        <property type="entry name" value="PROTEIN CREG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036911">
        <property type="entry name" value="CREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="6">
        <location>
            <begin position="99"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO41407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="296" mass="33394" checksum="325ECD4D3F6D53F7" modified="2016-06-08" version="1">MMLSPAWGYVIVNSVSWSVTNEVEEELDSSSNEEALPALLEDTTSIWKQSYPASVYKEDGQMRSRPVAGRSKQVSSPSRMFSYRRESVKGTDDSIAPLEQAIRTARFLSHYNSWGFLATQSTQEKIQGMPFGNYLPVSDGPINNSTGIPFFYVTPKDNSVADLMKNPVASLTLPEADGDFCRKNVIEPDNPRCAKLTLTGQMIMVPPEEMEFAKQAMFSRHPVIRKWPRNYEWFFMKMSVEHVWLHNWYGGVSTVAVEEYFKGVPRALIIQIFCRGDCGAYSQKAKGLVKDNSPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX76</accession>
    <name>A0A151NX76_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytokine receptor-like factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Thymic stromal lymphopoietin protein receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CRLF2</name>
        <name evidence="16" type="ORF">Y1Q_0006293</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX76"/>
    <dbReference type="STRING" id="8496.A0A151NX76"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001547">
        <property type="entry name" value="Cytokine receptor-like factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048651">
        <property type="entry name" value="CRLF2-like_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048648">
        <property type="entry name" value="CRLF2-like_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050676">
        <property type="entry name" value="IL-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48485:SF4">
        <property type="entry name" value="INTERLEUKIN-12 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48485">
        <property type="entry name" value="INTERLEUKIN-12 SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21605">
        <property type="entry name" value="CRLF2-like_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21604">
        <property type="entry name" value="CRLF2_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Cytokine receptor-like factor 2-like D1" evidence="14">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Cytokine receptor-like factor 2-like D2" evidence="15">
        <location>
            <begin position="115"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO41501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="369" mass="43475" checksum="560180C7D9CE6784" modified="2016-06-08" version="1">MVKRLISDVENDLFFLFNETGMEVSINVTIVNFDNEWIQMTWAAIENFPGKNVTFLYQYDKDPWKQCPSYLLDQGYNDGCLFKTEKPSLAISVKDKNGSEELFHKKLQTNFFIKPSPPENVTFLWKDNRVTVTCSKPKTSKRCLKLEFQYRSKFDTEWQSRKSPCCSLEDQGFDPEKCYSFRVRLERLYPTCNVVHYASEWGAVTFWSNGKMLESCADDIKPLSDAIILLIFLLMIFLIIFILLIFLCKWQRFQKSIMPVIPDPKYIFTDLFTDHNGNLQEWFDKTENAMVQAKMECEEQECIIEEERVQEKKKDVKGEAKQRLCELPNMHERDYLNFAQNTCLPPTSSDMVSLESFKFLMNEDMYVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXY4</accession>
    <name>A0A151NXY4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein uL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">60S ribosomal protein L10a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RPL10A</name>
        <name evidence="15" type="ORF">Y1Q_0002426</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001615">
        <property type="protein sequence ID" value="KYO41727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXY4"/>
    <dbReference type="STRING" id="8496.A0A151NXY4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008677">
        <property type="entry name" value="MRVI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15352">
        <property type="entry name" value="LYMPHOID-RESTRICTED MEMBRANE PROTEIN, JAW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15352:SF5">
        <property type="entry name" value="LYMPHOID-RESTRICTED MEMBRANE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05781">
        <property type="entry name" value="MRVI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="597"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="711" mass="78902" checksum="7E820C9C165B69BF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYT9</accession>
    <name>A0A151NYT9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras-related protein Rab-22A isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RAB22A</name>
        <name evidence="12" type="ORF">Y1Q_0002688</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYT9"/>
    <dbReference type="STRING" id="8496.A0A151NYT9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000346">
        <property type="entry name" value="RAB31, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO42037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="210" mass="23740" checksum="504C17F2FF513C35" modified="2016-06-08" version="1">MQAAGVSVIPVRRLWRPPRPDPPSAHFRDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFATLKNWVKELRQHGPPNIVVAIAGNKCDLNDVREVMEKDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDTNPQSSSKGFKLRRQPSVTKRSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0Q0</accession>
    <name>A0A151P0Q0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="21">3.1.-.-</ecNumber>
            <ecNumber evidence="21">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">DNA2</name>
        <name evidence="27" type="ORF">Y1Q_0022309</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="21"/>
    <dbReference type="EC" id="3.6.4.12" evidence="21"/>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
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        <property type="entry name" value="DNA2/NAM7-like_C"/>
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        <property type="entry name" value="DNA2_Rift"/>
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        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21123">
        <property type="entry name" value="Dna2_Rift"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 21" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17 21" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 21 27" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 21" id="KW-0408">Iron</keyword>
    <keyword evidence="14 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 21" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="23">
        <location>
            <begin position="70"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2 rift barrel" evidence="26">
        <location>
            <begin position="465"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="24">
        <location>
            <begin position="622"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="24">
        <location>
            <begin position="726"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="25">
        <location>
            <begin position="801"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
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    <evidence type="ECO:0000256" key="3">
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    <evidence type="ECO:0000256" key="4">
        <source>
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    <evidence type="ECO:0000256" key="5">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF21123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO42480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118561" checksum="4F08F4C0DE6DB167" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1K0</accession>
    <name>A0A151P1K0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZNF395</name>
        <name evidence="12" type="ORF">Y1Q_0016659</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001328">
        <property type="protein sequence ID" value="KYO42893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="8496.A0A151P1K0"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052253">
        <property type="entry name" value="CR1/CR2-DNA-binding_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031940">
        <property type="entry name" value="DUF4772"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006">
        <property type="entry name" value="PAPILLOMAVIRUS REGULATORY FACTOR PRF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006:SF6">
        <property type="entry name" value="ZINC FINGER PROTEIN 395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15997">
        <property type="entry name" value="DUF4772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="244"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO42893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="559" mass="60859" checksum="B337A8FFB30040F4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1P8</accession>
    <name>A0A151P1P8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin thioesterase otulin isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">OTULIN</name>
        <name evidence="7" type="ORF">Y1Q_0016204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C65 family. Otulin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001351">
        <property type="protein sequence ID" value="KYO42829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1P8"/>
    <dbReference type="STRING" id="8496.A0A151P1P8"/>
    <dbReference type="PhylomeDB" id="A0A151P1P8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990108">
        <property type="term" value="P:protein linear deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010803">
        <property type="term" value="P:regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22799">
        <property type="entry name" value="OTU_OTUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023235">
        <property type="entry name" value="FAM105"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023237">
        <property type="entry name" value="Otulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33662">
        <property type="entry name" value="OTU DEUBIQUITINASE WITH LINEAR LINKAGE-SPECIFICITY A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33662:SF2">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16218">
        <property type="entry name" value="Peptidase_C101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02055">
        <property type="entry name" value="PROTEINF105"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02057">
        <property type="entry name" value="PROTEINF105B"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linear diubiquitin binding" evidence="5">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linear diubiquitin binding" evidence="5">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linear diubiquitin binding" evidence="5">
        <location>
            <begin position="411"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linear diubiquitin binding" evidence="5">
        <location>
            <begin position="464"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="site" description="Linear diubiquitin binding" evidence="5">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623237-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623237-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO42829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="480" mass="54528" checksum="CC640CE6A1463F3B" modified="2016-06-08" version="1">MVPGGAPAAGPRGLALGPSAAADRPLPLPQGSSPGPGPTLGLGHESRRGGAAPKQRQPEEREAALGDQDRLEQKTSKPNGSSANVEERQKKVTTIFCLTKNEKEFYVPSDESCSASVATRQKQKRAVEIKEECTHKSHRRISQTDDMKAFLTHQAVCENCEVNLPGFSNSSAMESTVDNEEDMYRDAEEIEREKVLLVCERGSTENKLSVAPEMDIVEYCQKEWRGNTPVAKLMKKGYEAVSQKFACIRRVRGDNYCALRATLFQALSQATEQPNWLHSEDLMLLPEKLLSKYDWIKDWQHRGKLGRKMREIGDEIKEYLGLLRKKWKSVSEMKTPMEKQGACNELFKNEEEEYCLYEAVKFLMLNTAIELYNDNKEGKNVPVFSWLLFARDTSSNPKQLMNNHLNHIGHTGGLEQVEMFLLAYALRHTIKVYRLYKYSTDEFITHYPNDPEEDWPVVTLITEDDRHYNIPVGMCEETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P207</accession>
    <name>A0A151P207_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin-10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Y1Q_0017455</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P207"/>
    <dbReference type="STRING" id="8496.A0A151P207"/>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000008">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000009">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000012">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000017">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000014">
        <property type="entry name" value="Cadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000006">
        <property type="entry name" value="Cadherin-9 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF290">
        <property type="entry name" value="CADHERIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="547"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="19">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="105"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="214"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="329"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="433"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO43117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="733" mass="81845" checksum="9EACF6EF013D3165" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P314</accession>
    <name>A0A151P314_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel subfamily K member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KCNK5</name>
        <name evidence="16" type="ORF">Y1Q_0013502</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276051.1">
        <property type="nucleotide sequence ID" value="XM_006275989.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P314"/>
    <dbReference type="STRING" id="8496.A0A151P314"/>
    <dbReference type="GeneID" id="102559972"/>
    <dbReference type="KEGG" id="amj:102559972"/>
    <dbReference type="CTD" id="8645"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P314"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000077">
        <property type="entry name" value="Potassium channel subfamily K member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF241">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="172"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO43437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="484" mass="54978" checksum="7D2425C5263F1DC2" modified="2016-06-08" version="1">MVDRGPLLTSAIIFYLSIGAAIFEVLEEPNWRLATDAYKLQKSQLLKEFPCLGQEGLDKILQVVSNAAGQGVTITGNNTFNNWNWPNAVIFAATVITTIGYGNVSPKTPSGRLFCIFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRQAQITCTVIFIMWGVLIHLVIPPFVFMVTEGWDYIEGLYFSFITITTIGFGDFVAGVNPEANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRKKRKESFENHPQSKKALQMGTSKDVNIFSFLSKKEETYNDLIKQIGKKALKSNSDNNIIKTDHSKPNMQIANKDIQVTYTKSNSFNYDEVSLKLKNSRIARHLNDKQTDSPLDCNMFVNQLDRISEEEGEAWDSRDCRPLIFENANITFVNEDDDEEQDLSDDEETSKSSMDDNLVEEPETPKTLMKFSSSDESTFTSNELETSVPYEQLMNEYNTVNNGKATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3X3</accession>
    <name>A0A151P3X3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001130">
        <property type="protein sequence ID" value="KYO43748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3X3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8791" checksum="CEC9103111989466" modified="2016-06-08" version="1">MLFMQQLDFILAMRKCGHNRLLALKERDTVLLERMLKAHEWQAAMMAQAMEEMEEEGWVLDTILAMADTFMLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4N2</accession>
    <name>A0A151P4N2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Major histocompatibility complex class I-related protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0019426</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MHC class I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000987">
        <property type="protein sequence ID" value="KYO44006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4N2"/>
    <dbReference type="STRING" id="8496.A0A151P4N2"/>
    <dbReference type="PhylomeDB" id="A0A151P4N2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000204">
        <property type="entry name" value="Major histocompatibility complex, class I-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF242">
        <property type="entry name" value="MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0490">MHC I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="215"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO44006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="401" mass="44903" checksum="5D3379DBE954E166" modified="2016-06-08" version="1">MPGPSSAAPPGGGSEHPRALASAPTCADPCQSPTGSHSYWYFYTGVSDPSLDVPASTAVGYMDDQKILHYDSETRRQEPCGNWAQGVVGPDFCDNETRSLQGWQQEFGVNLGTLRQRYNQTDESHTLQFMYGFELHEDGSTGGYMQFGSDGEDFISYDLGTRTWIAVPAQAQITQRRWNEDKILFQIARAYLEESCIKWLQKYLQHGKAALLSKPPKTQVSDRPSSQDGLTTLSCRVHCFYPKEVAVVWLKNGEAQPQEMSHSGVIPSGDGTYQTWATININPSSNHDYTCSMEHVSLGEHLQAARDKSMMHVPAFTAMSYMDDQQILHYDSETRREEPRGDCVQGAVDPDFWDGETRSLRGWQWGFEANLVTLWQRYNQTSSDCGQTGMDRTMEDPGPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P536</accession>
    <name>A0A151P536_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0005946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000865">
        <property type="protein sequence ID" value="KYO44172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P536"/>
    <dbReference type="STRING" id="8496.A0A151P536"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586693" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO44172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="124" mass="13958" checksum="3ED91A6ABEEA7521" modified="2016-06-08" version="1">MGCFFTLFFLSAIPFLILAKIQFQMHQSGNGLVKPGETLTLTCAVSGFDISHSYWAWVRQHPEGELEVIGVGRYFGAKWYPIYTSAFKNRATISTDASTNHFDLQLHFMTAADTAAYYCARDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P755</accession>
    <name>A0A151P755_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein 8A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TMEM8A</name>
        <name evidence="11" type="ORF">Y1Q_0005924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000725">
        <property type="protein sequence ID" value="KYO44565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P755"/>
    <dbReference type="STRING" id="8496.A0A151P755"/>
    <dbReference type="eggNOG" id="ENOG502QQ7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319">
        <property type="entry name" value="FIVE-SPAN TRANSMEMBRANE PROTEIN M83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319:SF7">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="525"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO44565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="802" mass="90269" checksum="8C9AB768678B3623" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P877</accession>
    <name>A0A151P877_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KHDRBS3-1</name>
        <name evidence="9" type="ORF">Y1Q_0014683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHDRBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P877"/>
    <dbReference type="STRING" id="8496.A0A151P877"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22470">
        <property type="entry name" value="KH-I_KHDRBS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000030">
        <property type="entry name" value="KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoformX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032571">
        <property type="entry name" value="Qua1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032335">
        <property type="entry name" value="Sam68-YY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF29">
        <property type="entry name" value="KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16274">
        <property type="entry name" value="Qua1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16568">
        <property type="entry name" value="Sam68-YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO45233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="416" mass="46303" checksum="E7E6D91B50B6D4A7" modified="2016-06-08" version="1">MDDKYLPELMAEKDSLDPSFTHALRLVSQEIEKFQKGEGKEEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENAEVPVVRGKPPIRARGVPAPALARGRGGVPPPPAGVPRGAPAPRGVPPSRGPVSRGRGLLAPRARGVPPPAGYRPLPPPPAQETYGEYVSTACSPSPRMSPMPPGFCIDRGTERRFGLLHSLCPQVDGVNSRRAQEYDDGYGTAYDEQSYDSYDNSYSTQAQSGADYYDYGHGLSEETYDSYGQEEWTNSRHKTPSARTTKGSCILFKETLYVLRSKENKSPYLLTLWDFCHVSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P953</accession>
    <name>A0A151P953_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P953"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="12416" checksum="C6A33408404F2C33" modified="2016-06-08" version="1">MTFFILYLFGKEAGTKWQAQRSTLTCLVLQDDYDDHVAGCLQYGHTLRIPALLLLKFNPSEVHGKSHAFYNGLVCINSCHHSLFPIGIKLLSSVFNTTQTGPVSMWVPSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P962</accession>
    <name>A0A151P962_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-related BTB domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RHOBTB2</name>
        <name evidence="4" type="ORF">Y1Q_0015333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000547">
        <property type="protein sequence ID" value="KYO45572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P962"/>
    <dbReference type="STRING" id="8496.A0A151P962"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18531">
        <property type="entry name" value="BACK_RHOBTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003145">
        <property type="entry name" value="rho-related BTB domain-containing protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000014">
        <property type="entry name" value="Rho-related BTB domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="172"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="360"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO45572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="571" mass="65297" checksum="92847C946DA638C8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9U6</accession>
    <name>A0A151P9U6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Adhesion G protein-coupled receptor A3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">G-protein coupled receptor 125</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Y1Q_0021459</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Orphan receptor that may have a role in planar cell polarity pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts (via PDZ-binding motif) with DLG1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P9U6"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000011">
        <property type="entry name" value="adhesion G protein-coupled receptor A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000445">
        <property type="entry name" value="Adhesion G protein-coupled receptor A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000287">
        <property type="entry name" value="adhesion G protein-coupled receptor A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF2">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 21" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586828" description="Adhesion G protein-coupled receptor A3" evidence="21">
        <location>
            <begin position="21"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="883"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="972"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="299"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="23">
        <location>
            <begin position="380"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="22">
        <location>
            <begin position="638"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="24">
        <location>
            <begin position="811"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="995"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1005"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO45818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1021" mass="112876" checksum="FD254D99544C811D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PA84</accession>
    <name>A0A151PA84_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Gamma-aminobutyric acid receptor subunit gamma-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Y1Q_0021565</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PA84"/>
    <dbReference type="STRING" id="8496.A0A151PA84"/>
    <dbReference type="eggNOG" id="KOG3642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19000">
        <property type="entry name" value="LGIC_ECD_GABAAR_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19054">
        <property type="entry name" value="LGIC_TM_GABAAR_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000003">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit gamma-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005438">
        <property type="entry name" value="GABBAg1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005437">
        <property type="entry name" value="GABRG-1/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01620">
        <property type="entry name" value="GABAARGAMMA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01621">
        <property type="entry name" value="GABAARGAMMA1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022259665" description="Gamma-aminobutyric acid receptor subunit gamma-1" evidence="17">
        <location>
            <begin position="35"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="64"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="276"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO45958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="53731" checksum="53414876DAC4888D" modified="2016-06-08" version="1">MEPWRRPCGPSPPWHPGSGLRLLLLLLTVRLGSCADKADDEDDEDLTVNKTWVLAPKIHGGDVTHILDSLLQGYDSKLRPDIGVRTTVIEAGVYVNSIGPVDPINMEYTIDIIFAQTWYDSRLKFNSSMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRILYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPRNEIEYKWKKTSVEVADPKYWRLYQFAFVGLRNTTEISHTLSGEYIIMRIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTNNKKGSREKEKSKHKPSKSPAIAVRPGSTLIPINNLSHLPEHDDDYGYECLEGKDCTSFFCCFDDCRTGSWREGRIHIRVAKIDSYSRIFFPTAFALFNLVYWISYLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PF26</accession>
    <name>A0A151PF26_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PF26"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="9621" checksum="604993992E98346E" modified="2016-06-08" version="1">MTSLAPDKPSLPGRHQESTCLSQLQLCTYCSLGSARSCTSSVWLSPQEKGTNCSTEHRCLTVEKNCYIQIGKFPGISLAEQEALERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGF2</accession>
    <name>A0A151PGF2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000375">
        <property type="protein sequence ID" value="KYO47865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGF2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO47865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="169" mass="18201" checksum="022692799332E017" modified="2016-06-08" version="1">MESITSAVPGAEQARCLGRARKTADPTAFIKASPRKLGIRCGFQSLPPIAGSRSDRARVVGAAAEQHVLARGCGEGEDITPAPEDRPVLLPHDGQSLIPTGIERHSHPIPRLQELRLGEQERASRASPQLATPGSDTRLKRASLSARAELEEKKACEINFKLKTAIEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PH22</accession>
    <name>A0A151PH22_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000190">
        <property type="protein sequence ID" value="KYO48427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PH22"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033375">
        <property type="entry name" value="Cggbp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344:SF1">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="428" mass="47812" checksum="A6EE5389E951AB2F" modified="2016-06-08" version="1">MEEDEEEFSEPGRASSVVVERRVTVMEEKVNQDMRIELESKSDGPESDGRWLKVGKKERKASLALGVALIEPVLVSTGTLHADGDKLFCTTCNLTLDATRKGSINWHLEPEAHVERKAVTEADHQKKKQATMSSLFKKTTDSRLASKKAEFSLTEAFAAANILLEKLDHPELGDYLKNKCQMLAVFRELTKLHQDYLPAVIFSHAKFMKIVLSEDESFSVLADKATDPQDNYLLHVLYVLGSWTDRDLPVLQTEPILLTSVNFPTLCQAIVKIFCNYGIEFNQVSAFLSKSATYMCKAFTDVHQGMLPNTSCHLQCIHSFPRKPVEMGAVPGSNCKTKPILQAFHSWIWEDSPLDCLHTVSLPVSACLAPGTQGQYQNIACHTQHIVQQMKCISGFSTGLYWKKDLGFTVGTSALLHGQQQCKSKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PI25</accession>
    <name>A0A151PI25_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PI25"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="135" mass="15137" checksum="4F67C23FF9C9D8A6" modified="2016-06-08" version="1">MPRRQKILKNEALAAQLVNMPYPRLDSRVKRRGNFFLREIGSTVLCGNAEHSLIKESNSSCNGHVHKGSCWLVSQQDVIWLGSLVTRDELKMRKVSYTAEVDTSSSELSGPPAWLSYISICNLQHGRCVSMSNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYF4</accession>
    <name>A0A151LYF4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IF rod domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0017726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007029">
        <property type="protein sequence ID" value="KYO17281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYF4"/>
    <dbReference type="STRING" id="8496.A0A151LYF4"/>
    <dbReference type="eggNOG" id="ENOG502QQIF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF69">
        <property type="entry name" value="IF ROD DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="162"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="375"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO17281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="491" mass="53459" checksum="22CD69E96F13C965" modified="2016-06-08" version="1">MSRQSCGLNLAGGSRGFSSSSICLGGGNKVSFSAASRGGCGGSVRNPIGFGSRSLYNLGGCKRISIGGFGGNSGACGAFGAGGRGGGGFGYGGLGGGFGGGSGGGSGGGFGDGAGGMFNGWGGPSFPVCPPGGIQEVTVNQNLLIPLKLEIDPEIQKVRSQEREQMKTLNDKFASFIDKVRFLEQQNKVLETKWKLLQEQGQGTGPHSRSLDQLYEVYINSLRKQLDGLASEKSQLQLELKNCEDLVEDFKTKYDEEINKRTAAENDFVLLKKDVDAAYMNKVELQAKLDSLADELNFLRCVYDAELSQMQQTVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQKSRAEAESWYQCKYQELQVTAGKHGDSLKDTKAEISELNRMIQRLRAEIENVKKQCENLQTSVADAEQRGELALKDARVKLSELEAALQKAKTELTRQLRDYQELMNVKLALDIEIATYRKLLEGEECRWVQRGEDRTLGLTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZP5</accession>
    <name>A0A151LZP5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZP5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO17739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="10669" checksum="B0B08EFDA2F3F770" modified="2016-06-08" version="1">MVHAACPCLAGSGASCRDLDPAFARSLERAAHTPQNQSHQLKCCSYLLSLSPQPGLFEKTVVPKGNLASISRTLYWQISSERSAAHRTITSIIKMIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0G8</accession>
    <name>A0A151M0G8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADP-ribosylation factor-like protein 5A isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARL5A</name>
        <name evidence="9" type="ORF">Y1Q_0011616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014455076.1">
        <property type="nucleotide sequence ID" value="XM_014599590.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0G8"/>
    <dbReference type="STRING" id="8496.A0A151M0G8"/>
    <dbReference type="GeneID" id="102558398"/>
    <dbReference type="KEGG" id="amj:102558398"/>
    <dbReference type="CTD" id="26225"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903292">
        <property type="term" value="P:protein localization to Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04153">
        <property type="entry name" value="Arl5_Arl8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000294">
        <property type="entry name" value="ADP-ribosylation factor-like protein 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO18008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="179" mass="20573" checksum="D6AB7E9DF3FE81D5" modified="2016-06-08" version="1">MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEELVVNNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERITVTKEELYKMLAHEDLKKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSGLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0T7</accession>
    <name>A0A151M0T7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0T7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="153" mass="17361" checksum="047D1744CA5D9424" modified="2016-06-08" version="1">MASWVRSGPWNHWTWPVDMGLQWHLTVRVFGYRPRAAGYKCHPHATVETSIGIHRVLMAGSYRLPTHPLLSQSHNFQPVGLSHIASCSATHPQSLAYPFGSGKTCSFTLPSLQRLAYWKLKKCGDTIRRRECNLKWDPMNWRRRVGGGFGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M267</accession>
    <name>A0A151M267_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TFB1M</name>
        <name evidence="16" type="ORF">Y1Q_0009087</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="14"/>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M267"/>
    <dbReference type="STRING" id="8496.A0A151M267"/>
    <dbReference type="eggNOG" id="KOG0821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.100:FF:000004">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000109">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 14" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="15">
        <location>
            <begin position="38"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO18614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="342" mass="38954" checksum="F6887E777ACC7CF0" modified="2016-06-08" version="1">MVAALHLPPLPTIGEIIKLFHLQANKQLSQNFLLDLKLADKIVRQAGNLKDAHVCEVGPGPGGITRSILNANVAQLLLVEKDTRFIPGLQMLSEAAPGKVCIVHGDVLTYRMDRAFPEHLRKTWQDDPPNIHIIGNLPFSVSTPLIIKWLENVSNRDGPFFYGRTQMTLTFQKEVGERLIASTGSKQRSRLSIMSQHLCTVQNCFVIPGQAFIPKPKVDVAVVRFTPLVEPKILQPFKLVEKVVRSVFHFRRKFCWRGVGILFPEADRLKKTEQMMLTADVDPTLRPTQLTMLHFKGLCDAYRKMCDEDSSLFAYNYRDELKEKMRSKRDGHLKQLEEEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3B7</accession>
    <name>A0A151M3B7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">R-spondin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Roof plate-specific spondin-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RSPO3</name>
        <name evidence="19" type="ORF">Y1Q_0018936</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells. Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin. Interacts with LGR4, LGR5 and LGR6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the R-spondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3B7"/>
    <dbReference type="STRING" id="8496.A0A151M3B7"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000052">
        <property type="term" value="P:positive regulation of non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000003">
        <property type="entry name" value="R-spondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000043">
        <property type="entry name" value="R-spondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051514">
        <property type="entry name" value="R-spondin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043601">
        <property type="entry name" value="Rspo_Fu-CRD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987">
        <property type="entry name" value="NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987:SF1">
        <property type="entry name" value="R-SPONDIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15913">
        <property type="entry name" value="Furin-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584709" description="R-spondin-3" evidence="16">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="R-spondin Fu-CRD" evidence="17">
        <location>
            <begin position="43"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="148"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF15913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO18976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="240" mass="27427" checksum="D01CB6C6B203FE8F" modified="2016-06-08" version="1">MQLRLISWFLITLNFMEYIGSQHASRVRRQGRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCETCFTRNFCTKCKSGFYLYSGKCLENCPEGLETNNHTMECTSIVHCEASEWSPWSPCTKKGKTCGFKRGNEVRVREIVQQPSARGNPCPTTSESRKCIVQRKRCQKEGKGKKNREEKRRKPNEESKETRQENKDLECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5H4</accession>
    <name>A0A151M5H4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tumor necrosis factor alpha-induced protein 8-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TNFAIP8L2</name>
        <name evidence="4" type="ORF">Y1Q_0012331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006582">
        <property type="protein sequence ID" value="KYO19670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275460.1">
        <property type="nucleotide sequence ID" value="XM_006275398.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5H4"/>
    <dbReference type="STRING" id="8496.A0A151M5H4"/>
    <dbReference type="GeneID" id="102570439"/>
    <dbReference type="KEGG" id="amj:102570439"/>
    <dbReference type="CTD" id="79626"/>
    <dbReference type="eggNOG" id="ENOG502QST4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055976at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M5H4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050868">
        <property type="term" value="P:negative regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.160:FF:000001">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008477">
        <property type="entry name" value="TNFAIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757:SF4">
        <property type="entry name" value="TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757">
        <property type="entry name" value="TUMOR NECROSIS FACTOR INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05527">
        <property type="entry name" value="TNFAIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO19670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="184" mass="20655" checksum="AC7E6D9B5E721A3D" modified="2016-06-08" version="1">MEFSARSLVLQAEKKVLSRMAGKATATLLLDEVSGEVLDELYRVSKQHTQDRATAQRVIKDLVKVAVKVAVLFRNGCFGPTELDLAEDFRRKLRQGALTAVSFQEVEFTFEAGVLAGLLAESRDLLLRLVDKHLTPKSHGRIRHVFDHFGDAALLSQLYSPGPYRPHLDRLCRGLNQMLEEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7E7</accession>
    <name>A0A151M7E7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC1 domain family member 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0008983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006396">
        <property type="protein sequence ID" value="KYO20458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7E7"/>
    <dbReference type="STRING" id="8496.A0A151M7E7"/>
    <dbReference type="eggNOG" id="KOG2595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000024">
        <property type="entry name" value="TBC1 domain family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF11">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO20458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="285" mass="31990" checksum="AD911F4A65FB393F" modified="2016-06-08" version="1">MRAEQRQVLQEQLVDVIVALLSAHPELHYYQGYHDVAVTLLLTVGARMGLALLERLSTHHLRDFMDPTMDSTKHILNYLMPLLQRESPRLHDFMLRAEVGTIFALSWLITWYGHVLTDVRHVLRLYDLFLASHPLMPVYLAAAIVLHREEEVLTCSCDMPSVHQLLARLPPDLPFERLVARAQDLFRCHPHAELAKQAALQHHKSISIGSFSALQLAASCQRPDTVLRQLQQDSSTAPGVPMPAGRHHPLVKAAVWGLSATLGAAALAVTQTALEWAPEFLLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9A5</accession>
    <name>A0A151M9A5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9A5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584862" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8777" checksum="8EA9F45F559BBDE8" modified="2016-06-08" version="1">MSSHGLETAGSMSLVMVLAVCLGIEEEMPKGPGQERTRQKTISPDVTLRAALAVTRSLWTASGIFPSWNLFPAASLLMVFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9G0</accession>
    <name>A0A151M9G0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9G0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="108" mass="11995" checksum="C58DED4F512A8BBB" modified="2016-06-08" version="1">MAIGSTSCPLSAEVCQHAMKPKGGEKAKESRKGKNFNHFSEKGACEMRGYCNAVKSVTLCDLALMKHGTKQHLALLQSLDLTFRTSHNLILHLQKQSPKRSKLFKAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC51</accession>
    <name>A0A151MC51_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MC51"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="137" mass="14042" checksum="91E202797E4A2D27" modified="2016-06-08" version="1">MAAKGLAEKTPERHPGDLVPGIGSSEAELGNAPVSSGGPQPADGHGVQNNFGPLLPLPGLKEGSGSPGLPYPGVRAGEMRAAAAGHLQALGIIMEYATPRSAERIDIARLLSSERVEALAVLGQPRPFEPQHPYGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC97</accession>
    <name>A0A151MC97_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2 variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UEVLD</name>
        <name evidence="4" type="ORF">Y1Q_0000724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:23445"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:23446"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263543.1">
        <property type="nucleotide sequence ID" value="XM_006263481.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MC97"/>
    <dbReference type="STRING" id="8496.A0A151MC97"/>
    <dbReference type="GeneID" id="102558617"/>
    <dbReference type="KEGG" id="amj:102558617"/>
    <dbReference type="CTD" id="55293"/>
    <dbReference type="eggNOG" id="KOG1495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MC97"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF33">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UEV" evidence="3">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO22122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="480" mass="52869" checksum="F97B5BB45C79ADCA" modified="2016-06-08" version="1">MEFSEETLRKQLGKYKFRDLTIEELKNVNKIYPNFLFSMDTYTFKDGSQKDLLNFSGTVPITYHGRSYNIPVRLWILDSHPFAPPICFLKPTVNMGISVGKHVDAHGRIYLPYLQNWSHPKSTVIGLIKEMTAKFDEELPLYSLSSSDAARQLELLSFIAKFSEGETDMKSKSQVEKEKKNETCNKVTVIGAGDLGIACILAIAAKGAADQVVLLDPSEGAAKGGIMDLDIFDLPNVEISKDFSASADSKVVVFTVNYLGNAQSYLDVIQSNVDLFRGIVPAIAHHNQNSVLLVASHPVEIMTYVSWKLSAFPKSRVIGIGCNLDTERFQYVIANLLKAQTLGKEAWIIGEQGEGKVPAWTGSNSATCQTAAKSHHNSREQLANRAMEVLKGKGQRSWSVALSIADLIESILKDKRKVHSVSTLAKGCCSINSEVFLSMPCILGTNGVIETIKPEKEELVAAKLQNSASSIHDLQQQLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCB9</accession>
    <name>A0A151MCB9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Troponin I, fast skeletal muscle</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Troponin I, fast-twitch isoform</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TNNI2</name>
        <name evidence="10" type="ORF">Y1Q_0000758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to actin and tropomyosin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the troponin I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCB9"/>
    <dbReference type="STRING" id="8496.A0A151MCB9"/>
    <dbReference type="eggNOG" id="KOG3977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000002">
        <property type="entry name" value="troponin I, fast skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF15">
        <property type="entry name" value="TROPONIN I, FAST SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="109"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO22165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="264" mass="30747" checksum="EEAA31050AAE2166" modified="2016-06-08" version="1">MCPPDLCVGQKQLLLQAELCTLLPQGWCNAMYLLWPSGASLVPFGLWSMPLIQPDEFDTWDKQFGYYSNRHRVKPWVVREEILLLGKKKRRAATARRQHLKSVMLQIAAQELEKETAAKASEKANYLAEHCPSLSLPHSMQELQELCKKLHSKVEVVDEERYDIEVKLQKTKKELEDLSQKLFDLRGKFKRPPLRRVRMSADAMLRALLGSKHKVNMELRANLKQVKKEDTEKEKDLRDVGDWRKNIEEKSGMEGRKKMFETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDS3</accession>
    <name>A0A151MDS3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDS3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="81" mass="8946" checksum="CFCBD13C1ED969B8" modified="2016-06-08" version="1">MQTPYSGLVTSRSLKPLESRNAIHATPPLYMTKGSFSFTWEIKNSKENGKVSGATDKAKGDIALSHVSFILMAEMQLKENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDV7</accession>
    <name>A0A151MDV7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDV7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9442" checksum="731982E747817B81" modified="2016-06-08" version="1">MLHCSKPAPHLSQSVTSLRPGNCLSNPSLHLLLKNILPWLSSFKNSPTHWDRRLSPSIKSFTISLEAFQPMLKEGEGDIRMIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFQ5</accession>
    <name>A0A151MFQ5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SURF1</name>
        <name evidence="7" type="ORF">Y1Q_0005739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFQ5"/>
    <dbReference type="STRING" id="8496.A0A151MFQ5"/>
    <dbReference type="GeneID" id="102566664"/>
    <dbReference type="KEGG" id="amj:102566664"/>
    <dbReference type="eggNOG" id="KOG1563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MFQ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO23348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="308" mass="34906" checksum="419BE5BD2915B12C" modified="2016-06-08" version="1">MAAGGGRCLGRLLQLRGCAQIPNVSVRTFFAYPRTKARSGLLQGSKDVCLRLRRPKSGTADVIESGEDVAFRWGLLLIPVTTFCLGTWQVQRRKRKLKLIADLESRVGSEPVPLPSDPAELKELEYRSVKVRGYFDHSKELYVMPRSRVDPKREAREAGRLTSSPDNGANIITPFYCTDLGITILVNRGFVPKKKLKPETRLNGQVTDEIDLVGVVRLSETRRPFVPENNIERNHWHYRDLEAMAKVTGAEPIFIDADFRSTVPGGPIGGQTRVTLRNEHMQYIVTWYGLCAATSYLWYRRFIQKIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGY4</accession>
    <name>A0A151MGY4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HAO1</name>
        <name evidence="12" type="ORF">Y1Q_0002380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGY4"/>
    <dbReference type="STRING" id="8496.A0A151MGY4"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF107">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="291"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="314"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO23771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="367" mass="40152" checksum="9C1DB0D2AE0B480F" modified="2016-06-08" version="1">MSGKPVCIADFEQHAKEVLPKSVYDYYRSGADDQQTLADNVAAFSRLRLYPRMLRDVSVMDLSTCVLGQNVSMPICVGATAMQCMAHLDGETATARACRSMGTGMMLSSWATSSIEEVAEAAPDGLRWLQLYIYKDREVTKALVQRAEKAGYKGIFVTVDTPLLGKRFDDVRNRFQLPPYLRMKNFETNDLAFSSEKGYGENSGLAVYVAQAIDPSIQWKDVKWLRGLTSLPIVAKGILRADDAKEAVKHGVNGILVSNHGARQLDGVPATIDVLPEIVEAVAGKVEVFLDGGVRKGTDILKALALGAKAVFIGRPIIWGLVYQGEEGAKEVLQILKEELHLAMALSGCRSVKEIDRMLVDQKTVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MH62</accession>
    <name>A0A151MH62_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MH62"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="92" mass="10290" checksum="EC551C27B567436A" modified="2016-06-08" version="1">MVTSSWIDRKIQPLPFICASSGRGLSENQLDQVLLIGLTRDITDVFNLYVGRMRLSTRMSITCMSITYRDQSLTVKFGTLADRATITIQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHI1</accession>
    <name>A0A151MHI1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CSC1-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0015915</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHI1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF38">
        <property type="entry name" value="CSC1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585117" description="CSC1-like protein 2" evidence="10">
        <location>
            <begin position="19"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="69"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="191"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="11">
        <location>
            <begin position="384"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="11">
        <location>
            <begin position="511"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO23953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="80245" checksum="1CFBD066BF9106A6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHS0</accession>
    <name>A0A151MHS0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protocadherin-20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0004651</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO24072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHS0"/>
    <dbReference type="STRING" id="8496.A0A151MHS0"/>
    <dbReference type="eggNOG" id="ENOG502QU9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000005">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000016">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000145">
        <property type="entry name" value="protocadherin-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000162">
        <property type="entry name" value="Protocadherin-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF260">
        <property type="entry name" value="PROTOCADHERIN-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="100"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="203"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="323"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="418"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="522"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="628"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO24072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="833" mass="91864" checksum="F21AFD24DA321B02" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MI29</accession>
    <name>A0A151MI29_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">KIF3C</name>
        <name evidence="13" type="ORF">Y1Q_0020289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006102">
        <property type="protein sequence ID" value="KYO24176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MI29"/>
    <dbReference type="STRING" id="8496.A0A151MI29"/>
    <dbReference type="eggNOG" id="KOG4280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01371">
        <property type="entry name" value="KISc_KIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000017">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="351"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO24176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="389" mass="43940" checksum="47A0735A06AF62CC" modified="2016-06-08" version="1">MNGKEKAASYDKVVDVDVKLGQVSVKNPRGTSHELPKMFTFDSVYDWNSKQVELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQSKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSELGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANIGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSVGKRKKRERRREGGEEEEDDDDDDAEEAWWLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MII9</accession>
    <name>A0A151MII9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MII9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO24344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19322" checksum="F78DAC1608EA955D" modified="2016-06-08" version="1">MAMVFTKRAIPIIRNQFNMAPCMAKVTICELMGDWCLLSQVGATAEAVSGSGGRDKADKHPQKPPAASASESGLEVKAAAPATWSILPLSQVPGVAGPVPGKRYEAHQVSLSITCGVSGASVSSHYWHWLRQPPELGSSGWAPFRAAWSLEPATTTQLWPPKFASPRTPGRRRCRCSRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIJ3</accession>
    <name>A0A151MIJ3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prostaglandin G/H synthase 2</fullName>
            <ecNumber evidence="7">1.14.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Cyclooxygenase-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">PHS II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Prostaglandin H2 synthase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Prostaglandin-endoperoxide synthase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="primary">PTGS2</name>
        <name evidence="40" type="ORF">Y1Q_0004260</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="40 41" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="40">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:75455"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:136655"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:75456"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:75451"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:90850"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:75452"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:75447"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:77895"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:75448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:75459"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:77852"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:75460"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prostaglandin G/H synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="37">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="40">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.1" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267636.1">
        <property type="nucleotide sequence ID" value="XM_006267574.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIJ3"/>
    <dbReference type="STRING" id="8496.A0A151MIJ3"/>
    <dbReference type="GlyCosmos" id="A0A151MIJ3">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="106736995"/>
    <dbReference type="KEGG" id="amj:106736995"/>
    <dbReference type="CTD" id="5743"/>
    <dbReference type="eggNOG" id="KOG2408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MIJ3"/>
    <dbReference type="UniPathway" id="UPA00662"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004666">
        <property type="term" value="F:prostaglandin-endoperoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019371">
        <property type="term" value="P:cyclooxygenase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09816">
        <property type="entry name" value="prostaglandin_endoperoxide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000002">
        <property type="entry name" value="Prostaglandin G/H synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000235">
        <property type="entry name" value="Prostaglandin G/H synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF8">
        <property type="entry name" value="PROSTAGLANDIN G_H SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="37" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="25" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="26" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 36" id="KW-0349">Heme</keyword>
    <keyword evidence="21 36" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 36" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="9" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 38" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="38">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585167" description="Prostaglandin G/H synthase 2" evidence="38">
        <location>
            <begin position="19"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="39">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="35">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="For cyclooxygenase activity" evidence="35">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="36">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="36">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00030839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00031216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00031793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00033144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00035976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00036313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00036358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00036409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="KYO24210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="605" mass="69073" checksum="614C7DE2AF2CCE00" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIJ7</accession>
    <name>A0A151MIJ7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIJ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9481" checksum="270B6A23F2856516" modified="2016-06-08" version="1">MAIIGIGVQMKEEVTLKVLHICWRRKVLWVTGHPLENGMTTLEKSMSSLKRAEGAEVTAHHQLPCNTKGLEEQSRNQCKVQVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIK5</accession>
    <name>A0A151MIK5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional protein SWT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SWT1</name>
        <name evidence="5" type="ORF">Y1Q_0004267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIK5"/>
    <dbReference type="STRING" id="8496.A0A151MIK5"/>
    <dbReference type="eggNOG" id="KOG4689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000012">
        <property type="entry name" value="SWT1, RNA endoribonuclease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="4">
        <location>
            <begin position="391"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00060839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00074620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO24220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="824" mass="92745" checksum="ED6E673D5B6573D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJB1</accession>
    <name>A0A151MJB1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJB1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="10037" checksum="4799B03C2E1BCA0F" modified="2016-06-08" version="1">MTECVHQAFAPWSSHSSFTLLSSEVSIERSSVSLKSNSVVLQDRQHEMEGGGKWTGGGGFTLWYSTVSVPGISLTRDSEDFQFPLLSAPAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJN6</accession>
    <name>A0A151MJN6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPF2</name>
        <name evidence="9" type="ORF">Y1Q_0017817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006032">
        <property type="protein sequence ID" value="KYO24727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261670.1">
        <property type="nucleotide sequence ID" value="XM_006261608.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJN6"/>
    <dbReference type="STRING" id="8496.A0A151MJN6"/>
    <dbReference type="GeneID" id="102561066"/>
    <dbReference type="KEGG" id="amj:102561066"/>
    <dbReference type="CTD" id="84154"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MJN6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="8">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO24727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="307" mass="35410" checksum="B91287F8FB7DC2AB" modified="2016-06-08" version="1">MEPLDRVLKPKTKRAKRFLEKREPKLTENTKNAMLIKGGNANLTVTGVLKDIYALKKPFAVLYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLIIGCMFDYHVLDMIELGIEKFVSLKEIKNSKCPEGTKPMLIFAGDMFDLSEEYRRLKSLLIDFFKGPTVPYVRLAGLEHVLHFTAMDGKIYMRSYKVLLKKSGCKIPRIELEDMGPSLDLVMRRTHLASDDLYKLSLKQPKALKPKKKKNISRDVFGTTYGRIHMKKQDLGKLQTRKMKGLRKRPAERMTGDGERISPKKTKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJP6</accession>
    <name>A0A151MJP6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Decaprenyl-diphosphate synthase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PDSS2</name>
        <name evidence="2" type="ORF">Y1Q_0017783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006032">
        <property type="protein sequence ID" value="KYO24683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019355453.1">
        <property type="nucleotide sequence ID" value="XM_019499908.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJP6"/>
    <dbReference type="STRING" id="8496.A0A151MJP6"/>
    <dbReference type="GeneID" id="102558152"/>
    <dbReference type="KEGG" id="amj:102558152"/>
    <dbReference type="CTD" id="57107"/>
    <dbReference type="eggNOG" id="KOG0776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9983019at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO24683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="389" mass="42391" checksum="2B1F7F88E103DFF6" modified="2016-06-08" version="1">MRSLQLLRALRGGGRARVAVAVAGRRGLLSAPGSAASWSKVVSEAEKLVGYPTSFLSLRCLLSDELSNVALQVRKLVGTKHPLLSTAREFVYDNQNNLQMRGLVVLLISKAAGPSSKVELSSQPDMVSGIYSSQRSLAEITELIHTAFLVHRGIVNIGELKSCDGPMKDMQFGNKMAVLSGDFLLANACTSLAQLHNTKVVELISSAIGDLVQGIYYENSTLEETRLTDDIGISTWTEQIFLSHSALLAKSCKAAMELAKHDAEIQKMAFHYGKHMSMSHKIHLDLQPFIKGNSTDSVTFSLNSAPAVLHQEFLGREAWIKQIREAQGAGSILDYMKLQEAIKAGKGVTSAIDLCRYHGNRALEALECFPPSEARSALENIVYAVTRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJP7</accession>
    <name>A0A151MJP7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006032">
        <property type="protein sequence ID" value="KYO24737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJP7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585222" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO24737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16213" checksum="7387DA38CD1B7921" modified="2016-06-08" version="1">MCHMQRLHGPIVTLMLQLASPILGYGNRDDQQVASWHLILEIKPGNQDHRQGQEPETGSRLEQGVRYSSGLLKGFKVNGKRVSDIREERCITLLDCVCVHSCRSDWQHKSKICGWLEAGRPALWNSFWTNFKMGCCGCLQETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJT5</accession>
    <name>A0A151MJT5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006003">
        <property type="protein sequence ID" value="KYO24801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJT5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="12551" checksum="5E11B270EF45A62A" modified="2016-06-08" version="1">MQVEIRSNPRIHLLFPTSKAASEQVRDVTGWTEIRYPIFRDEEEEEESKLELICKMQTGNGTSRTPTARSAQASLPSMLVESPIKKGFVKLKTKGTSALGLPFLIAQESCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKZ9</accession>
    <name>A0A151MKZ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="13">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">PIF1</name>
        <name evidence="16" type="ORF">Y1Q_0012398</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03005990">
        <property type="protein sequence ID" value="KYO25060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKZ9"/>
    <dbReference type="STRING" id="8496.A0A151MKZ9"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000805">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003367">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 13 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="14">
        <location>
            <begin position="57"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="15">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="13">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO25060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="479" mass="53073" checksum="864B4FCEFD96F3EF" modified="2016-06-08" version="1">MEPDPDADPDPCCSVRCRAAVEHEAGAGRRRTIRDARVALARNELRELEQALVLSAALSGRSVFFTGSAGTGKSYLLKKILGSLPPKSTYATASTGVAACHIGGTTLHAFAGIGSGKAPLEQCIQLAQRLGVRQHWLGCQHLIIDEISMVDGEFFDKLEAVARAVRKRDDPFGGIQLIICGDFLQLPPVCKGNDQIKFCFQAKSWRKCIHVNMELTEVRRQTDKAFISLLRAVRLGRCPDEVTWQLTQTAANRVERDGILATRLCTHKDDVELTNERRLQQLPGERRCFEAVDSDPMLAKLIDAQCPVGHHIELKPGAQVMLTKNLDVSRGLVNGARGVVVEFEAGGKGLPRVRFLCGVTEVIKLERWIFKGPSGVHLSRQQLPLKLAWAISIHKSQGMSLDCVEISLSRVFESGQAYVALSRARSLKGLRVLDFDPKVVKANPQVLQFYSQLRRDQILIQAPLHRYADTDEKENWESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMP9</accession>
    <name>A0A151MMP9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0023625</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RBR family. RNF19 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMP9"/>
    <dbReference type="STRING" id="8496.A0A151MMP9"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20363">
        <property type="entry name" value="BRcat-RBR_RNF19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20355">
        <property type="entry name" value="Rcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000001">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000004">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="14"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="559"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO25818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="636" mass="69056" checksum="0E48BDB2A95A1F4D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN19</accession>
    <name>A0A151MN19_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN19"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="12311" checksum="AE6A059951781628" modified="2016-06-08" version="1">MLGQEQGIPLHLIQEQGIPLHISFERLDLLELQCSKDNSRNLYMGVVHRSTLHTLSLTESCVNSRTPKAVHLPLLLCPVYTCLFLSGNCILTPAPLPCSAARPSLQTSSTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRM8</accession>
    <name>A0A151MRM8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0013424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005337">
        <property type="protein sequence ID" value="KYO27133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRM8"/>
    <dbReference type="STRING" id="8496.A0A151MRM8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050831">
        <property type="entry name" value="CEA_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427:SF1">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO27133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="139" mass="14476" checksum="F20EBCB8129747BE" modified="2016-06-08" version="1">MKPSWFAASLGPNSVFGFPGVKETLSQPKVMPPNITVVESWTLKSTCETPTGTKTLLWDHDDSVLVPGGCVGLSPGNRALTVLGVSQDDAGNYTCEVRNPVSHNRSRPVTVTVVYGLDAATVAPPGLLDQAVGSGLGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MT98</accession>
    <name>A0A151MT98_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DPY30 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DYDC2</name>
        <name evidence="4" type="ORF">Y1Q_0005252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dpy-30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MT98"/>
    <dbReference type="STRING" id="8496.A0A151MT98"/>
    <dbReference type="GeneID" id="102575212"/>
    <dbReference type="KEGG" id="amj:102575212"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22966">
        <property type="entry name" value="DD_DYDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049630">
        <property type="entry name" value="DYDC-like_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037856">
        <property type="entry name" value="Sdc1/DPY30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356:SF16">
        <property type="entry name" value="DPY30 DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356">
        <property type="entry name" value="DPY30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO27694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="208" mass="23743" checksum="751F677BC2220FCA" modified="2016-06-08" version="1">MGMDTHYLRKCVGKHLAEGLAEVAEHHPADPIDYLAHWLYNYRKNIKEGEERKLKAATLEQEQEKVTRHLELIENQKAEELLIKQEIEEQHEKMITDQCPADATAQLIEKYDTPNLPTVVEPKENVLRKGSKEKEMYILVEAKAIETKPKAPEDKVNGGDSTYEDHEMNESLDIVNNETVYQVPNDAAAEKGSLELSEEVADKAKESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTL2</accession>
    <name>A0A151MTL2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">POLA2</name>
        <name evidence="11" type="ORF">Y1Q_0006896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005076">
        <property type="protein sequence ID" value="KYO27843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTL2"/>
    <dbReference type="STRING" id="8496.A0A151MTL2"/>
    <dbReference type="GeneID" id="102561698"/>
    <dbReference type="KEGG" id="amj:102561698"/>
    <dbReference type="CTD" id="23649"/>
    <dbReference type="eggNOG" id="KOG1625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000002">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000003">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="10">
        <location>
            <begin position="217"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="342"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO27843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="597" mass="66433" checksum="1DEF23D2C8FA501C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTL8</accession>
    <name>A0A151MTL8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Adenosine receptor A3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ADORA3</name>
        <name evidence="16" type="ORF">Y1Q_0020985</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005066">
        <property type="protein sequence ID" value="KYO27861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTL8"/>
    <dbReference type="STRING" id="8496.A0A151MTL8"/>
    <dbReference type="KEGG" id="amj:102572719"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MTL8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001609">
        <property type="term" value="F:G protein-coupled adenosine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000466">
        <property type="entry name" value="Adeno_A3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001634">
        <property type="entry name" value="Adenosn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF2">
        <property type="entry name" value="ADENOSINE RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00555">
        <property type="entry name" value="ADENOSINEA3R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00424">
        <property type="entry name" value="ADENOSINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 14 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="29"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU201114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO27861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="323" mass="36133" checksum="3C9B61503A182057" modified="2016-06-08" version="1">MTNSSVSLSTQDAIYIAVESIIAVSATVGNALVIGVVKLNPSFQNTTFYFIISLALADIAVGLLVMPLAIVVSQGLVIPFYACLFVCCLLIFFTNASILSLLAIAIDRYLRVKLHTRYKIITTQRRIWVALGLCWLVSLLTAFVPMFGWNKKETVIGTSNSSCLQCKFTAVIRMDYMVYFGFFICILIPLIIMCVLYVEVFYIIYMKLSQSTASIKMAGGFYGKEFKTAKSLALVLFLFAVSWLPLCIFNCISYFCHDCDIPKPLLYLGILLSHANSAMNPIVYACRIKKFKETYILIFKTYILCTDSEQVISSIETPSDRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTQ9</accession>
    <name>A0A151MTQ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0006527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005057">
        <property type="protein sequence ID" value="KYO27901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTQ9"/>
    <dbReference type="STRING" id="8496.A0A151MTQ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001568">
        <property type="term" value="P:blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045765">
        <property type="term" value="P:regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF272">
        <property type="entry name" value="BMP-BINDING ENDOTHELIAL REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="VWFC" evidence="6">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="5">
        <location>
            <begin position="89"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO27901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20157" checksum="5ADAA4686F14309B" modified="2016-06-08" version="1">MCDPGLYRNGSGRCVPAAHCECQHRGRLYPPGAEWHEDCETCRCLNGRGVCMAGCPPLSCLEGEVKVQEPGSCCPVCRTESLEEPSAACQRYTEVRNITKGRCSLRGVEVSYCRGRCLSRTNVLPEEPYLQTLCDCCSYRLDPVSPVRLLSLRCEDGEVEPVVLPVIHSCECSSCQGGDFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVF9</accession>
    <name>A0A151MVF9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgin subfamily A member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GOLGA7</name>
        <name evidence="10" type="ORF">Y1Q_0015482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004909">
        <property type="protein sequence ID" value="KYO28474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273578.1">
        <property type="nucleotide sequence ID" value="XM_006273516.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVF9"/>
    <dbReference type="STRING" id="8496.A0A151MVF9"/>
    <dbReference type="GeneID" id="102559429"/>
    <dbReference type="KEGG" id="amj:102559429"/>
    <dbReference type="CTD" id="51125"/>
    <dbReference type="eggNOG" id="KOG4069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MVF9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF1">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="9">
        <location>
            <begin position="12"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO28474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="137" mass="15764" checksum="FCC95B39333A7074" modified="2016-06-08" version="1">MRPQPAPVSGKVFVQRDYSSGTRCQFQTKFPAELETRIDRQQFEETVRTLNNLYAEAEKLGGQSYLEGCLACLTAYTIFLCMETHYEKVLKKIAKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGMSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWQ9</accession>
    <name>A0A151MWQ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Complement C1q tumor necrosis factor-related protein 3 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">C1QTNF3-1</name>
        <name evidence="8" type="ORF">Y1Q_0009806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWQ9"/>
    <dbReference type="STRING" id="8496.A0A151MWQ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585529" evidence="6">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="182"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO28983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="306" mass="33473" checksum="2FB671BC3B2EAB7D" modified="2016-06-08" version="1">MAVKDFISWYLLALFFLPFCLCQDEYVEVSRGSYKPVAKVLQSHHQTGHKGSRSREILRQRSQLVEWTIDDNSTSTDQKAQRPEVDDVEQTTSDRVQPPPSGPQNTDCSACCRGDFGMKLYQGPPGPPGPAGMPGNHGNNGNNGATGHDGAKGEKGDKGDLGPRGDRGHHGPKGEKGYPGIPPELQVAFMASMATHFSNQNSGIIFSSVETNVGNFFDVMTGRFGAPVNGVYFFTFTMMKHEDVEEVYVYLMHNGNTVFSLYSYESKGKSDTSGNSAVLKLAKGDEVWLLKTEVHFDAAPLFRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWY9</accession>
    <name>A0A151MWY9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibroblast growth factor</fullName>
            <shortName evidence="6">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FGF10</name>
        <name evidence="7" type="ORF">Y1Q_0009874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWY9"/>
    <dbReference type="STRING" id="8496.A0A151MWY9"/>
    <dbReference type="eggNOG" id="KOG3885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23320">
        <property type="entry name" value="beta-trefoil_FGF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000004">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="5" id="KW-0497">Mitogen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO29071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="164" mass="18765" checksum="9CF9801C8D16F44B" modified="2016-06-08" version="1">MLLSFPAGMPACAGRHVRSYNHLQGDVRWRKLYSYNKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKSINSNYYLAMNKKGKVYGSKEFNSDCKLKERIEENGYNTYASLNWKHNGRQMFVALNGKGATKRGQKTRRKNTSAHFLPMNLKDVRQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXA9</accession>
    <name>A0A151MXA9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="18">HMG-CoA synthase</shortName>
            <ecNumber evidence="18">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0009866</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:10189"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXA9"/>
    <dbReference type="STRING" id="8496.A0A151MXA9"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF4">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="7" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="19">
        <location>
            <begin position="39"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="20">
        <location>
            <begin position="213"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="16">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO29059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="548" mass="60257" checksum="871C6FD1DD6CE567" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXB6</accession>
    <name>A0A151MXB6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA excision repair protein ERCC-8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ERCC8</name>
        <name evidence="16" type="ORF">Y1Q_0009941</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes. Following recruitment to lesion-stalled RNA polymerase II (Pol II), the CSA complex mediates ubiquitination of Pol II subunit POLR2A/RPB1 at 'Lys-1268', a critical TC-NER checkpoint, governing RNA Pol II stability and initiating DNA damage excision by TFIIH recruitment. The CSA complex also promotes the ubiquitination and subsequent proteasomal degradation of ERCC6/CSB in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. Also plays a role in DNA double-strand breaks (DSSBs) repair by non-homologous end joining (NHEJ).</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the CSA complex (also named DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Interacts with ERCC6/CSB (via CIM motif); promoting recruitment to lesion-stalled RNA polymerase II (Pol II). Interacts with KIAA1530/UVSSA. Interacts with a subunit of RNA polymerase II TFIIH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258785.1">
        <property type="nucleotide sequence ID" value="XM_006258723.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXB6"/>
    <dbReference type="SMR" id="A0A151MXB6"/>
    <dbReference type="STRING" id="8496.A0A151MXB6"/>
    <dbReference type="GeneID" id="102574571"/>
    <dbReference type="KEGG" id="amj:102574571"/>
    <dbReference type="CTD" id="1161"/>
    <dbReference type="eggNOG" id="KOG4283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MXB6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000130">
        <property type="entry name" value="DNA excision repair protein ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO29157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="399" mass="44346" checksum="354839E407B26876" modified="2016-06-08" version="1">MLGFISARQAGLDDPLRLRRAESTRRVLSLELNKDRDVERIHGSGINTLDIEPVEGRYMLSGGSDGVVILYDLENFSKKPCYTCKAVCSVGRSHPDVHRFSVETVQWYPHDTGMFTSSSFDKTLKIWDTNTLQPADIFNFEGTVYSHHMSPIATKHCLIAVGTKSPKVHLCDLKSGSCSHILQGHRQEVLAVSWSPRYEHVLATASADSRVKLWDVRRASGCLFTLDQHNGEKSKASSEAANTAHNGRVNGLCFTSDGLHLLTVGTDDRMRLWNSSTGQNTLVNYGKVCNTSRKGIKFAISRGCNPEFAFVPYESNIAVYTVYSGELITMLRGHYSTVDCCVFQSDFQELYSGSKDCTILAWVPALREPVPEEDNEKSLPLQSLNPAYEDAWSSSDDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZ58</accession>
    <name>A0A151MZ58_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0023159</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MZ58"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000021">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000006">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000010">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000037">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000077">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031688">
        <property type="entry name" value="CAC1F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005452">
        <property type="entry name" value="LVDCC_a1dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF11">
        <property type="entry name" value="VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16885">
        <property type="entry name" value="CAC1F_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01636">
        <property type="entry name" value="LVDCCALPHA1D"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 20" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="11 20" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="976"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1022"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1149"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1228"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1258"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1381"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1473"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="23">
        <location>
            <begin position="1630"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="786"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1767"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1988"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="786"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1784"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1808"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1120"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="19">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO29802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2184" mass="247703" checksum="659C7BC6EC386F33" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZK4</accession>
    <name>A0A151MZK4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004389">
        <property type="protein sequence ID" value="KYO29961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZK4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7228" checksum="F3FF3804EC74492E" modified="2016-06-08" version="1">MVPSASEDEEDAPAAEANPSAPALAEPRRRLMLHATSSRSDSSGFVEESAPGRTPMAQLTDAPLPPGQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZL6</accession>
    <name>A0A151MZL6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Solute carrier family 2, facilitated glucose transporter member 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucose transporter type 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glucose transporter type X1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC2A8</name>
        <name evidence="19" type="ORF">Y1Q_0005432</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-dehydroascorbate(out) = L-dehydroascorbate(in)</text>
            <dbReference type="Rhea" id="RHEA:60380"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)</text>
            <dbReference type="Rhea" id="RHEA:17629"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004379">
        <property type="protein sequence ID" value="KYO30003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZL6"/>
    <dbReference type="STRING" id="8496.A0A151MZL6"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033300">
        <property type="term" value="F:dehydroascorbic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904659">
        <property type="term" value="P:D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF18">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="18">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO30003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="425" mass="46783" checksum="664A669F50F96244" modified="2016-06-08" version="1">MPVCDSFPQSVVTLGAAAGGVLGGYAVDKLGRKLSLMLCSVPYIFGFMIIISAHNVWMLYCGRILTGLASGVTSLVVPVYISEISHSKVRGTLGSCVQLMVVTGILGAYVAGIALEWRWLAVLCSFPPCLMVIFMSFMPETPRYLLNRNKHPEAIAALKFLRGPHVDHEWELRQIETSAEEQHGLSLAEFKSPSIYKPFFIGVALMFFQQATGINAVMFYAETIFEEASFKDSRMASVVVGSIQVCFTAVAALIIDKTGRKVLLCVSGIVMAISTAAFGFYFKMILPNQNNSSHPDLLTTPNCISSVAEHDLTWLAVVSLGLFITGFALGWGPIPWLVMSEIFPLKARGFSSGACVLTNWLMAFLVTKEFNDLMDVLTSYGTFWLFSAFCILNRQTAEWTRAELIWFSFRLLQGTLTCDLVPLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZM2</accession>
    <name>A0A151MZM2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0017316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004386">
        <property type="protein sequence ID" value="KYO29967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZM2"/>
    <dbReference type="KEGG" id="amj:106738753"/>
    <dbReference type="OrthoDB" id="6145535at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15231">
        <property type="entry name" value="7tmA_OR5V1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000015">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050516">
        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO29967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="264" mass="30023" checksum="0A81162E8730BB24" modified="2016-06-08" version="1">MYFFLGHLAFLDMCYSSVTLPKILVNFLRQQQTISYRECMAQMFFLMSCSGAEGTLLAVMAFDRYAAICKPLHYIYIMNKKVCVPLATVSWLWGILNSTMHTFLTTNVSFCGDNQIYHIFCDVPPLLKIACSDTYINEIILHLASVFMGMSPFLSIVISYLYILLAILRIHSNTGRHKAFSTCTSHLVMVIIYFGMANLNYNRPRAGYSLEVDTLVSTLYCILTPMLNPLIYSLRNQDMKGALRRALGWHEKDNASPRTQPGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZT3</accession>
    <name>A0A151MZT3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004329">
        <property type="protein sequence ID" value="KYO30076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZT3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="7956" checksum="E8EC6E217973F839" modified="2016-06-08" version="1">MPPSRFLETSRPCFQFSTYKQHVIYQGLSLPLAATTGGLGHSSCSKPERLFCFGGRSVQACWLEGGAGDRALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3Y5</accession>
    <name>A0A151N3Y5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Centrosomal protein of 104 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CEP104</name>
        <name evidence="15" type="ORF">Y1Q_0005998</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for ciliogenesis and for structural integrity at the ciliary tip.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with CCP110 and CEP97. Interacts with ARMC9, TOGARAM1, CCDC66 and CSPP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3Y5"/>
    <dbReference type="STRING" id="8496.A0A151N3Y5"/>
    <dbReference type="eggNOG" id="KOG4825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000200">
        <property type="entry name" value="Centrosomal protein of 104 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048738">
        <property type="entry name" value="CEP104_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21039">
        <property type="entry name" value="CEP104_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="14">
        <location>
            <begin position="457"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="343"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="710"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO31397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="955" mass="108313" checksum="8396B8A3A286E5D2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7E9</accession>
    <name>A0A151N7E9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM122A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM122A</name>
        <name evidence="3" type="ORF">Y1Q_0009356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7E9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF3">
        <property type="entry name" value="PABIR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO32753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="313" mass="34779" checksum="8C57AAF2D2A51726" modified="2016-06-08" version="1">MWAAVEWEQRVRVPLLPGSNLGEGRLRADARVLLAATSCDNSQVFQANILRTRRNSTTVMNRHSLLLPSSPVRIPSSRLHQIKREEGMSLMNRETVHEREVQTAMQMSQSWEESLSLSDSDFEKSSSPKQVDFVPVSPAPSPTRGIGKQCFSPALQSLVSSSGLPPSPSPSPTRRFSNRRSQSPINCIRPSVLGSIKRKGEMETEDPPKRFFQGTPSMLLPEVSHLTDLGACLSSHALDDNRNSAGSSCDSPGQRRHTRRKLKLGNMKICDDGGLKIYFRSSPVINTYTGVKLVEKKHLNAPNGRKRQSTFMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7L8</accession>
    <name>A0A151N7L8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Putative ATP-dependent RNA helicase TDRD12</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ES cell-associated transcript 8 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tudor domain-containing protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TDRD12</name>
        <name evidence="19" type="ORF">Y1Q_0007782</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of a mRNP complex containing PIWIL2, TDRD1 and piRNAs. Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AKHW03003905">
        <property type="protein sequence ID" value="KYO32589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7L8"/>
    <dbReference type="STRING" id="8496.A0A151N7L8"/>
    <dbReference type="GeneID" id="102561428"/>
    <dbReference type="KEGG" id="amj:102561428"/>
    <dbReference type="CTD" id="91646"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249932at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042078">
        <property type="term" value="P:germ-line stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20434">
        <property type="entry name" value="Tudor_TDRD12_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20435">
        <property type="entry name" value="Tudor_TDRD12_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000075">
        <property type="entry name" value="putative ATP-dependent RNA helicase TDRD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000087">
        <property type="entry name" value="Putative ATP-dependent RNA helicase TDRD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000021">
        <property type="entry name" value="putative ATP-dependent RNA helicase TDRD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001517">
        <property type="entry name" value="Putative ATP-dependent RNA helicase TDRD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000067">
        <property type="entry name" value="Tudor domain-containing 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047390">
        <property type="entry name" value="Tudor_TDRD12_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655:SF2">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="CS" evidence="18">
        <location>
            <begin position="1102"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO32589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1241" mass="142047" checksum="1ECD4EEED5FBE995" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7N6</accession>
    <name>A0A151N7N6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Melatonin-related receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GPR50</name>
        <name evidence="15" type="ORF">Y1Q_0009413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019348315.1">
        <property type="nucleotide sequence ID" value="XM_019492770.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7N6"/>
    <dbReference type="STRING" id="8496.A0A151N7N6"/>
    <dbReference type="GeneID" id="109280200"/>
    <dbReference type="KEGG" id="amj:109280200"/>
    <dbReference type="CTD" id="9248"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904408">
        <property type="term" value="F:melatonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008502">
        <property type="term" value="F:melatonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046325">
        <property type="term" value="P:negative regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000056">
        <property type="entry name" value="Melatonin receptor type 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002279">
        <property type="entry name" value="Mel_rcpt_1C"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01150">
        <property type="entry name" value="MELATONIN1CR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00857">
        <property type="entry name" value="MELATONINR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="36"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024876"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO32834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="341" mass="38138" checksum="9FDD0B1D1A9B9732" modified="2016-06-08" version="1">MPGGNESCAGCGLAQSPAPLLLAAVLIFTIVADVLGNVLVILAVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILSAIFHNGWTMGNIHCQISGFLMGLSVIGSIFNITAIAINRYCYICHSLRYDRLFNLKNTCCYLCLTWTLTVVAIVPNFFVGSLRYDPRIYSCTFAQTVSTSYTISVVVVHFIVPLSVVTFCYLRIWILVIQVKQRVRPDCKQKLRAGDMRNFLTMFVVFVLFAVCWGPLNFIGLAVSINPSKVAPQIPEWLFVLSYFMAYFNSCLNAMIYGLLNQNFRKEYKRILLTLWTPRLLFVDLSKVGTEGMKSKPSPAATNNNRAEMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7Y0</accession>
    <name>A0A151N7Y0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003855">
        <property type="protein sequence ID" value="KYO32861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7581" checksum="20164436CB9F145E" modified="2016-06-08" version="1">MVIFSVLGFEPSGIKVRVVYMERVHAKWRQDLPGPGDAENNLPEQDHQHLLSGAHQAAETSCWENPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N842</accession>
    <name>A0A151N842_ALLMI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003826">
        <property type="protein sequence ID" value="KYO32931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7497" checksum="C898060287489432" modified="2016-06-08" version="1">MKDKKITGAVMHNTVKTELLWAGPGQAAASPRRGSSPPEADKNILPRKPVQNQYNLNGSGYFDIGDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8N7</accession>
    <name>A0A151N8N7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LZTR1</name>
        <name evidence="5" type="ORF">Y1Q_0014972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019348071.1">
        <property type="nucleotide sequence ID" value="XM_019492526.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8N7"/>
    <dbReference type="GeneID" id="102577194"/>
    <dbReference type="CTD" id="8216"/>
    <dbReference type="eggNOG" id="KOG4693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N8N7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18505">
        <property type="entry name" value="BACK1_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18506">
        <property type="entry name" value="BACK2_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18308">
        <property type="entry name" value="BTB1_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18309">
        <property type="entry name" value="BTB2_POZ_LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000054">
        <property type="entry name" value="Leucine-zipper-like transcription regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000065">
        <property type="entry name" value="Leucine-zipper-like transcription regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000024">
        <property type="entry name" value="Leucine-zipper-like transcriptional regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000049">
        <property type="entry name" value="leucine-zipper-like transcriptional regulator 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="387"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="617"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO33193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="790" mass="90078" checksum="321B58F44E3E2222" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9X2</accession>
    <name>A0A151N9X2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">M-AAA protease-interacting protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9X2"/>
    <dbReference type="STRING" id="8496.A0A151N9X2"/>
    <dbReference type="KEGG" id="amj:102574898"/>
    <dbReference type="eggNOG" id="ENOG502QR8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7249367at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N9X2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333:SF5">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26529" checksum="FF3159BDA22710A6" modified="2016-06-08" version="1">MALPRALWRGPWPLRALLCPALPPAPRAGLRPPARSCSGDSGGGKARVRLRRGQISVEVVGIWQPRKWLRTRIRSFLIRTFLDHDFSLKDFTRGSKQAFALVSNQLSQCKLDLLEELVSKEVFQVWKERLALLSDDNKNALTVDMDKIMLAAAEDIHIYFDDSGRRFARILMGFWYFSSAVISEGSPVGAKVFSFGPEKAKLVVTAKYEFQREFTQGVKPDWTITWIEYPQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAZ1</accession>
    <name>A0A151NAZ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0024582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAZ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="16357" checksum="46D9395992480C40" modified="2016-06-08" version="1">MTIAPFYKQLSCILVKDIGVARLQSTASPSLQESTDCPATAICTVKPSEDDTSDSMMVVFPEWWDMPEIPETQRIVSAPETHEDPCPETSTTSTGRCGYAPEAWTPAWTRAERMCEHWHRQRQARESMMEALVMALESQVWSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBT7</accession>
    <name>A0A151NBT7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GRK5</name>
        <name evidence="16" type="ORF">Y1Q_0018153</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03003560">
        <property type="protein sequence ID" value="KYO34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBT7"/>
    <dbReference type="STRING" id="8496.A0A151NBT7"/>
    <dbReference type="eggNOG" id="KOG0986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000009">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000074">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001100">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF26">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="14">
        <location>
            <begin position="59"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="186"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="449"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="566"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="597" mass="68514" checksum="7C5952376D2F4D2E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBX9</accession>
    <name>A0A151NBX9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Immunoglobulin C1-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003541">
        <property type="protein sequence ID" value="KYO34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBX9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin C1-set" evidence="1">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="172" mass="18321" checksum="EC785265298701B3" modified="2016-06-08" version="1">MFLAKSLFLSCLDSFTEDSSVLLLRPGAGEKGATDPAHLACAIRGISNLVQVSWSVPGEEPTQGLPHLLEASDGSLTLIHHISIPWASWASVVAVTCELTFNSSGSSVTRHAIYSASPRSGCRQEAMRYMVVGLLVLLMVSLTSLWMCVCSSPGNLHIPSLPWPSSLSAPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCE9</accession>
    <name>A0A151NCE9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003406">
        <property type="protein sequence ID" value="KYO34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCE9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="10693" checksum="DEAEA5C81D5C3989" modified="2016-06-08" version="1">MPGCPVWAVMFTTKLAGRRAPFPTCLDPCPDEETGLEVTAPLQGLGLTPQSKRGQPSPGAANALLLSGETLGKSVTRSLLFSSSQDTSPCPMEPGLAANISEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCP8</accession>
    <name>A0A151NCP8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KLHDC4</name>
        <name evidence="2" type="ORF">Y1Q_0021137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003390">
        <property type="protein sequence ID" value="KYO34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCP8"/>
    <dbReference type="STRING" id="8496.A0A151NCP8"/>
    <dbReference type="GeneID" id="102559279"/>
    <dbReference type="KEGG" id="amj:102559279"/>
    <dbReference type="CTD" id="54758"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="588" mass="65945" checksum="4915175EC3C11ECD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEJ7</accession>
    <name>A0A151NEJ7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEJ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="94" mass="10659" checksum="A0A91A637CF92077" modified="2016-06-08" version="1">MECNRTGKRISARGEAWNRVRELPPKSESSEHVVEYGELCHVAEKSWRTGHPATSSRHRLFPTYPSSCMLVSVYKLAGSFCCQLPVTTQATRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEW8</accession>
    <name>A0A151NEW8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEW8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="106" mass="12288" checksum="A696F45F917E2A97" modified="2016-06-08" version="1">MNQSSCRQLRSDYHQSVQRFDWTGMLLPSSRFPPPHSSVYSPYFALKIETLKGASLAVQQQCLWIGSQEQAMLSSFPENRSRGKLRRKRVQWQMDILSLSSLILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NF57</accession>
    <name>A0A151NF57_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SUN domain-containing protein 3 isoform D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SUN3</name>
        <name evidence="10" type="ORF">Y1Q_0001056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus inner membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NF57"/>
    <dbReference type="STRING" id="8496.A0A151NF57"/>
    <dbReference type="eggNOG" id="KOG2687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000009">
        <property type="entry name" value="SUN domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF24">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="9">
        <location>
            <begin position="333"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO35175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="494" mass="55927" checksum="B7DE2B5F563437EF" modified="2016-06-08" version="1">MKRPGRSGSPRSEVEEAEAVLLQLLPIQELFLLKCVQCISTREQLYYFTHHCFISIVMDGKKNLRRSPRLSSTALHGLEADSDMSDNPKGPAMSGLPTNSRYLYSQTVLGSHSTESTLTGSSQGLTNPSEKGQTSDSEVFTRMSYLAMENNRHISPANESRPSQKSVLRMILNIPCLLLMAFVSLPRYLVKACISSVELITLQNVKMIFKILLLLIPMISAGFYCIDWFSSWRLREEEMSQLHGVEMKSYWKSYILLKQQFNEIEDLKKEMDLLRAELDNVKNGILHSVKQTLEENGIPVDNKDHVLEMINSQFKKIYEDDVQMPDWAQKTIGATIDASRTSKSYEPRNEEDSWFSLSFLSSANPPDTILQPDVSPGSCWAFPGSQGQVVIKLPEKIQPTAVTIQHISKAISPSGEVTSAPKDFAVYGLDEKTEILLGKFMYDLEKEVIQTFQLQMELPASFIYIKFSMLSNWGHSDYTCIYRVRVHGKMVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFB1</accession>
    <name>A0A151NFB1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Forkhead box protein F2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FOXF2</name>
        <name evidence="6" type="ORF">Y1Q_0008045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFB1"/>
    <dbReference type="STRING" id="8496.A0A151NFB1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051770">
        <property type="entry name" value="Forkhead_box_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46262">
        <property type="entry name" value="FORKHEAD BOX PROTEIN BINIOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46262:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="241" mass="26248" checksum="68477CE3BD8A2767" modified="2016-06-08" version="1">MSQPPAASALESSGLRRPEKPPYSYIALIARFPFFRGSYQGWKNSGLGRPGKGHYWTIDPASEFMFEEGSASLLPQGFDFQAPSAPLACHANGYNLDMMPNSMAGAYEGHHVPHMSPNPGSTYMASCPVPANGDPSAHWTASGASPYIKQQALPPSNAAPSGIHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSSPVCDRKDFVLNFNGISSFHPSASGSYYHHHHHQSVCQDIKPCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG49</accession>
    <name>A0A151NG49_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cryptochrome-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CRY2</name>
        <name evidence="10" type="ORF">Y1Q_0010204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG49"/>
    <dbReference type="STRING" id="8496.A0A151NG49"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000004">
        <property type="entry name" value="Cryptochrome-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="264"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="362"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO35782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="506" mass="57841" checksum="63D5C87D5487782F" modified="2016-06-08" version="1">MKDCSELYPIFILDPWFPKNMQVSVNRWRFLVESLKDLDESLKKLNSRLFVVRGHPAEVFPGLFKAWKVTRLTFEVDTEPYSKQRDAEVVRLAAAHGVQVIQKVSHTLYDTDRVIAENNGKVPLTYRQLQAVLAGLGPPKQPVLAPTLETLKDCCTPGRDNRDPKYEIPTLEELGQDPKEAGPCLYPGGESEALSRLAFHMKRMTWVCNFKKPDTEPNTLSPSTTVLSPYVKFGCLSVRTFWWKLAEIYRGKKHSSPPVSLHGQLLWREFFYTAGAGIPNFNRMEGNPICVQVDWDDNPEYVKAWKEGRTGYPFIDAIMTQLRTEGWIHHLARHAVACFLTRGDLWVSWEEGQKVFEELLLDADWSLNAGNWQWLSASAFFHQFFRVYSPVAFGKKTDKSGAYIKKYLPILRKFPAEYIYEPWKAPRSMQEQAGCIIGRDYPKPIVEHEALSKRNIMRMKAAYAQRSHSKAAQVEKESTKKGGKRKLPAGPSVVELLTKKPKAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHB3</accession>
    <name>A0A151NHB3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0022908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002957">
        <property type="protein sequence ID" value="KYO36206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHB3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO36206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="174" mass="19194" checksum="11496F8E23052D0F" modified="2016-06-08" version="1">MNHMGFFYQGVSAGPAQGRGAWLLSRAEEGPASLEPPGITPGRLALAAHRKIHPEEVPHHLTRFRRSFVWHSEHWRLHARDKPRRYLECGKSFTCSTNRAQQQRIHKGQKAHQCSECGKSFTQSSHLANHQLGDISENQPSSSPSILVKDARSAWALSLGILLAGPGNMGFGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHP7</accession>
    <name>A0A151NHP7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor SOX-10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SOX10</name>
        <name evidence="12" type="ORF">Y1Q_0024100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHP7"/>
    <dbReference type="STRING" id="8496.A0A151NHP7"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048484">
        <property type="term" value="P:enteric nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007422">
        <property type="term" value="P:peripheral nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22031">
        <property type="entry name" value="HMG-box_SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000004">
        <property type="entry name" value="Transcription factor SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022151">
        <property type="entry name" value="Sox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF6">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12444">
        <property type="entry name" value="Sox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="11">
        <location>
            <begin position="153"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="153"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO36341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="518" mass="56077" checksum="AFC25271A76305CF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHV8</accession>
    <name>A0A151NHV8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NOL12</name>
        <name evidence="9" type="ORF">Y1Q_0024111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259031.1">
        <property type="nucleotide sequence ID" value="XM_006258969.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHV8"/>
    <dbReference type="STRING" id="8496.A0A151NHV8"/>
    <dbReference type="GeneID" id="102575431"/>
    <dbReference type="KEGG" id="amj:102575431"/>
    <dbReference type="CTD" id="79159"/>
    <dbReference type="eggNOG" id="KOG4709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NHV8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO36354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="209" mass="24383" checksum="23CD43DBE98C1319" modified="2016-06-08" version="1">MGRRRPVGRGEPRRAVVFDEEQRREYLTGFHKRKVERRKAAVEEIKRKLKEEQRKMKEERHKEYLKMLTEREEALDEADELEHLVTSQTESVNIDHPNHTVTVTTISDLDLSGARQLGLTTHEENADSREEETTSRPTKVLPKKSGDPLFSQRISLLTASLHTRNQKKAKGKRLRHGQDSHKKNQKPSTGRTSKSQRRKLTGRLRHNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK92</accession>
    <name>A0A151NK92_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-like protein subfamily B member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DNAJB2</name>
        <name evidence="3" type="ORF">Y1Q_0014610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002857">
        <property type="protein sequence ID" value="KYO37099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK92"/>
    <dbReference type="STRING" id="8496.A0A151NK92"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO37099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="204" mass="22200" checksum="08CE30A9568E04CF" modified="2016-06-08" version="1">MGAGAGGPQADVGVPEFPFTFRSAYDVFREFFGGRDPFAEFFDDVLPFSEMRGPSSRPPGPGHFFSPFPASSDFFSSSFGSDAGVGFRSVSTSTTFVNGRRITTKRIVENGQERVEVEEDGELKSIHINGVPDDLALGLELSRREQQPLEGRRPPSPLPQPPPQRASPVALCTDSEDEDEDLQLAMAYSLSEMEAQGPHRTGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NL16</accession>
    <name>A0A151NL16_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Transient receptor potential cation channel subfamily V member 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Calcium transport protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Epithelial calcium channel 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">Y1Q_0015244</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002692">
        <property type="protein sequence ID" value="KYO37502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NL16"/>
    <dbReference type="STRING" id="8496.A0A151NL16"/>
    <dbReference type="KEGG" id="amj:102570188"/>
    <dbReference type="eggNOG" id="KOG3676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22296">
        <property type="entry name" value="CBD_TRPV5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22192">
        <property type="entry name" value="TRPV5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000143">
        <property type="entry name" value="transient receptor potential cation channel subfamily V member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000230">
        <property type="entry name" value="transient receptor potential cation channel subfamily V member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008346">
        <property type="entry name" value="TRPV5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008344">
        <property type="entry name" value="TRPV5/TRPV6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF25">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01765">
        <property type="entry name" value="ECACCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01767">
        <property type="entry name" value="ECACCHANNEL2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 24" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="26" id="KW-0732">Signal</keyword>
    <keyword evidence="7 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586153" description="Transient receptor potential cation channel subfamily V member 6" evidence="26">
        <location>
            <begin position="26"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="27">
        <location>
            <begin position="338"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00068288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00075384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KYO37502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="735" mass="83622" checksum="BBF31A36C7DCA0F6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLM6</accession>
    <name>A0A151NLM6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">A-kinase anchor protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AKAP12</name>
        <name evidence="9" type="ORF">Y1Q_0021995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002600">
        <property type="protein sequence ID" value="KYO37693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NLM6"/>
    <dbReference type="eggNOG" id="ENOG502RDV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010739">
        <property type="term" value="P:positive regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090036">
        <property type="term" value="P:regulation of protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028540">
        <property type="entry name" value="AKAP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001573">
        <property type="entry name" value="AKAP_WSK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23209">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23209:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03832">
        <property type="entry name" value="WSK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51893">
        <property type="entry name" value="AKAP_CAM_BD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding" evidence="8">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding" evidence="8">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding" evidence="8">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1199"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1711"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1862"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1408"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1441"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1862"/>
            <end position="1887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO37693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1999" mass="221932" checksum="226CAD5110C0190A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLS2</accession>
    <name>A0A151NLS2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002646">
        <property type="protein sequence ID" value="KYO37619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="11156" checksum="32473193C97CCB12" modified="2016-06-08" version="1">MTSAPALPPGPGPRTRARWDRGSPSAPRNAQTTATRLREVPEPEQHCGTEPVSCPQHLWFAPCPPGTHXXXXPPPPIAPTGRERPGRSRPGVPSVHLDSGPTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NM73</accession>
    <name>A0A151NM73_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoenolpyruvate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0010347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002566">
        <property type="protein sequence ID" value="KYO37911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NM73"/>
    <dbReference type="STRING" id="8496.A0A151NM73"/>
    <dbReference type="eggNOG" id="ENOG502QREJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051549">
        <property type="entry name" value="PEP_Utilizing_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43615:SF1">
        <property type="entry name" value="PPDK_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="3">
        <location>
            <begin position="377"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO37911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1252" mass="139587" checksum="3DE2C4F4542FCAB8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMI2</accession>
    <name>A0A151NMI2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TBATA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002540">
        <property type="protein sequence ID" value="KYO37984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMI2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037394">
        <property type="entry name" value="TBATA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33772:SF2">
        <property type="entry name" value="RIKEN CDNA 4930579F01 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33772">
        <property type="entry name" value="THYMUS, BRAIN AND TESTES-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15256">
        <property type="entry name" value="SPATIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38730" checksum="CDCB6AF80EF8E18A" modified="2016-06-08" version="1">MIWSMLPLLMKHSPHPRTVCHIQGLNNAPVCVVKDAGNFSRQQITSKIIIPQQEHDKLVLTGNAMGATSANQAMPSFQAYPSKGKSPSWPGSYHRREELAELSKRTRNWTDSSITKEDTWKKQLETRPPSATDHDVHLSSLNHPSSPIHSMYYRPGINSCAPHVPGYLDQEIKILEKLCNILQTDSLAEIHAWLSNASLREKEVVSNLVRSEMTGRDLLSYQQHALNTDAEENLTFPDTLKAPAINRTEPREGVSQLRPSSKASEASRGMEQERDEEGHLFTRQRNTSPVSESLRPRKPANRPRTEMSRSPAAALQRPHLRYTRTPLSQRGSLSREEIPHQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP07</accession>
    <name>A0A151NP07_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Kv channel-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KCNIP2</name>
        <name evidence="14" type="ORF">Y1Q_0005858</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002441">
        <property type="protein sequence ID" value="KYO38567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP07"/>
    <dbReference type="STRING" id="8496.A0A151NP07"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000043">
        <property type="entry name" value="Kv channel-interacting protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF65">
        <property type="entry name" value="KV CHANNEL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO38567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="259" mass="29131" checksum="9EF328022F761ECC" modified="2016-06-08" version="1">MPLGSWVVALGPACPSIHPSVAGSGLEASWGGAVPGPARKALKQRFLKLLPCCRPQATPSLSQNSVEDELELATVCHRPEGLEQLQEQTRFSRKELQVLYRGFKNECPSGLVTEESFKQIYSQFFPQGDSSTYAAFLFNAFDTDHDGSISFEDFVAGLSIILRGSVDDRLSWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKCTYPAMREEAPHEHVESFFQKMDRNKDGVVTIEEFIESCQKDENIMRSMQLFDNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP35</accession>
    <name>A0A151NP35_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">A-kinase anchor protein 14 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AKAP14-1</name>
        <name evidence="1" type="ORF">Y1Q_0015508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP35"/>
    <dbReference type="STRING" id="8496.A0A151NP35"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053084">
        <property type="entry name" value="AKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025663">
        <property type="entry name" value="AKAP_28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35075">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35075:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14469">
        <property type="entry name" value="AKAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="203" mass="24110" checksum="B766704BF7D31E81" modified="2016-06-08" version="1">MQGIKKPCYLLGIMSVTDASALRQIMDMEEEDEAIREKAQSLIETVIKGVKEQLEALQKKERGGLFSEADYVIGNIQWIACKDFTVERGRQQIEEYISTWEFHESWLHWSDFLKEEQLKYSKRYHYRVRWSIPTCRKPIPQATACIYFIVEISNIKPPTLPIEVFFILESNRLIHRPGRCRFREKWLKDIIESKMILMESITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVD3</accession>
    <name>A0A151NVD3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PERQ amino acid-rich with GYF domain-containing protein 2 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GIGYF2</name>
        <name evidence="5" type="ORF">Y1Q_0013208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the GIGYF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001930">
        <property type="protein sequence ID" value="KYO40385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014454352.1">
        <property type="nucleotide sequence ID" value="XM_014598866.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVD3"/>
    <dbReference type="GeneID" id="102570469"/>
    <dbReference type="CTD" id="26058"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990635">
        <property type="term" value="C:proximal dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048009">
        <property type="term" value="P:insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.40:FF:000001">
        <property type="entry name" value="GRB10-interacting GYF protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF38">
        <property type="entry name" value="GRB10-INTERACTING GYF PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="4">
        <location>
            <begin position="530"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="818"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="952"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1004"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1226"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="818"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="895"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="952"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO40385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1276" mass="147309" checksum="C70376B88F346B4C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVT2</accession>
    <name>A0A151NVT2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001868">
        <property type="protein sequence ID" value="KYO40699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVT2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="241" mass="27372" checksum="EDD0A5E24198AD90" modified="2016-06-08" version="1">MPLNKMMPIEETLNPGCRPVLQRPPNSPNAEETWDSSGSFPRPRLRNRRGSLHCPSFKCFPDTRINWESLQEPLVNGFIPQYLGGGGIEATLDETVKLAKTGFDLGSNHDNERWIASKISVVSRHGIPSSCRRRLKRCCRAPRVCGDGNHQAPFGERQENKFRGGFCSAIPHPSEQRLQFEAARDINRRRRRRPKHRSRREECGVTRACEHPPSSAPSRRAVIPSPAGEEVEEEEDEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWA0</accession>
    <name>A0A151NWA0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="14">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GALT</name>
        <name evidence="17" type="ORF">Y1Q_0016949</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in galactose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="14"/>
    <dbReference type="EMBL" id="AKHW03001793">
        <property type="protein sequence ID" value="KYO40950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWA0"/>
    <dbReference type="STRING" id="8496.A0A151NWA0"/>
    <dbReference type="eggNOG" id="KOG2958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 14" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="15">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="16">
        <location>
            <begin position="121"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO40950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="292" mass="33615" checksum="DE544619EAFF23C0" modified="2016-06-08" version="1">MTVNPEYESTFVFDNDFPALEPDAPEPDVGDHPLFRSASAQGVCKVMCFHPWSDMTLPLMALPEIRAVIDKWAELAVELGATYPWVQIFENKGAMMGCSNPHPHCQVWASNFLPNEARLEDRTQREHLQAHGQPLLLEYGRLEAQRKERLVVENTDWLVVVPYWAVWPFQTLLLPRRHVTRLQDLSADERDSLASIMKRLLTKYDNLFEVSFPYSMGWHGAPMGPHLGEDCGHWLLHAHYYPPLLRSASVRKFMVGYEMLAQAQRDLTPEQAAQRLRSLPEEHYRTRAQAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX03</accession>
    <name>A0A151NX03_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0006156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NX03"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586442" description="Collagen IV NC1 domain-containing protein" evidence="10">
        <location>
            <begin position="28"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen IV NC1" evidence="11">
        <location>
            <begin position="1446"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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            <begin position="1102"/>
            <end position="1114"/>
        </location>
    </feature>
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        <location>
            <begin position="1203"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1335"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1351"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1414"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO41304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1709" mass="165890" checksum="8F1AB8467FB3815B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXR6</accession>
    <name>A0A151NXR6_ALLMI</name>
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        <submittedName>
            <fullName evidence="7">Interferon regulatory factor 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">IRF7</name>
        <name evidence="7" type="ORF">Y1Q_0006318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="8496.A0A151NXR6"/>
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    <dbReference type="KEGG" id="amj:102564189"/>
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    <dbReference type="eggNOG" id="ENOG502R2I9">
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    </dbReference>
    <dbReference type="OrthoDB" id="8691508at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd00103">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
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        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Interferon_reg_factor-3"/>
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        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTERFERON REGULATORY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10401">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
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        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="6">
        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO41543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="605" mass="69395" checksum="3823E52ADC756437" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY66</accession>
    <name>A0A151NY66_ALLMI</name>
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        <submittedName>
            <fullName evidence="10">Cadherin-related family member 5 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDHR5-1</name>
        <name evidence="10" type="ORF">Y1Q_0006316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY66"/>
    <dbReference type="STRING" id="8496.A0A151NY66"/>
    <dbReference type="GeneID" id="102564418"/>
    <dbReference type="CTD" id="53841"/>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8958491at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF414">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586496" evidence="8">
        <location>
            <begin position="24"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="119"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="245"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="735"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="791"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="470"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="796"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="843"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="857"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO41539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="914" mass="97181" checksum="3BE598CB44D7363F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2Z3</accession>
    <name>A0A151P2Z3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein lin-7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LIN7B</name>
        <name evidence="13" type="ORF">Y1Q_0016915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001215">
        <property type="protein sequence ID" value="KYO43105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014461074.1">
        <property type="nucleotide sequence ID" value="XM_014605588.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2Z3"/>
    <dbReference type="STRING" id="8496.A0A151P2Z3"/>
    <dbReference type="GeneID" id="102558434"/>
    <dbReference type="KEGG" id="amj:102558434"/>
    <dbReference type="CTD" id="64130"/>
    <dbReference type="eggNOG" id="KOG3550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10029564at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P2Z3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097025">
        <property type="term" value="C:MPP7-DLG1-LIN7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06796">
        <property type="entry name" value="PDZ_Lin-7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000076">
        <property type="entry name" value="Protein lin-7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017365">
        <property type="entry name" value="LIN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038039">
        <property type="entry name" value="Lin-7_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="L27" evidence="12">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="94"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO43105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="208" mass="22854" checksum="E965BD12BEE56F56" modified="2016-06-08" version="1">MASLSSEPLGLERDVARAVELLERLQRSGELPPQKLQALQRVLQSKFCSAIREVYEQLYDTLDIAGSAEIRAHATAKATVAAFAASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRIIPAGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGTVKLVVRYTPKVLEEMEARFEKMRTARRRQQHASYSSLESRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3J2</accession>
    <name>A0A151P3J2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase ULK4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ULK4</name>
        <name evidence="3" type="ORF">Y1Q_0017598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P3J2"/>
    <dbReference type="eggNOG" id="KOG0597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14010">
        <property type="entry name" value="STKc_ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056981">
        <property type="entry name" value="HEAT_ULK4_RUNKEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045906">
        <property type="entry name" value="ULK4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46240">
        <property type="entry name" value="SER/THR PROTEIN KINASE ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46240:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23606">
        <property type="entry name" value="HEAT_ULK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO43315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1357" mass="151890" checksum="17A436D92AC81763" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P403</accession>
    <name>A0A151P403_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TOM1-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0008391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TOM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001118">
        <property type="protein sequence ID" value="KYO43791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P403"/>
    <dbReference type="STRING" id="8496.A0A151P403"/>
    <dbReference type="KEGG" id="amj:102573758"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14238">
        <property type="entry name" value="GAT_TM1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16996">
        <property type="entry name" value="VHS_Tom1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000001">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000003">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014645">
        <property type="entry name" value="TOM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027429">
        <property type="entry name" value="TOM1L2_VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF31">
        <property type="entry name" value="TOM1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036948">
        <property type="entry name" value="TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="7">
        <location>
            <begin position="219"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO43791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="55552" checksum="9DAD5489121EDB30" modified="2016-06-08" version="1">MEFLLGNPFSTPVGQSLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLNGNKNYREVMLALTVLETCVKNCGHRFHVLVANRDFIDGVLVKIISPKNNPPTIVQDKVLALIQAWADAFRSSPDLTGVVHIYEELKRKGIEFPMADLDALSPIHTPQRSVPEVDPAATMPTSQSQQRMSTSSYSSPSPTAYSAPQAPPLNVTGPITANSEQIARLRSELDIVRGNTKVMSEMLTEMVPGQEDSSDLELLQELNRTCRAMQQRIVELISRVSNEEVTEELLHVNDDLNNVFLRYERFERYRSGRSAQNASNGVLNEVTEDNLIDLGPGSPAVVSPMVGSTAPPPSLSSQLAGLDLGTNSVSGTLSSLQHCNPRDDFDMFAQTRGSSLADQRKSVTYEDPQAVKGLASALDVRKQNAGGIPVAQSSVMDDIEEWLSTDLKGDELEEGVTSEEFDKFLEERAKAAEMVPNLPSPPLEAPTPPANPPGRKKQERSEDALFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5J8</accession>
    <name>A0A151P5J8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LIM and SH3 domain protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LASP1-1</name>
        <name evidence="23" type="ORF">Y1Q_0012063</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5J8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09447">
        <property type="entry name" value="LIM_LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11934">
        <property type="entry name" value="SH3_Lasp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000087">
        <property type="entry name" value="LIM zinc-binding domain-containing Nebulette"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000007">
        <property type="entry name" value="nebulin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035630">
        <property type="entry name" value="Lasp1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF2">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0440">LIM domain</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 19" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="11 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="22">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="210"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="123"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO44283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="269" mass="30893" checksum="6051BA0ADBD7FCDA" modified="2016-06-08" version="1">MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQIRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGSSSGEGGEMERRNSQDGANYRRPTEQQQHHQQPHHIQPSNPAPFLPSYQQQQQQPSSHSYGYKEPAAPVSIQRSVPSGGGKRFRAVYDYNAADEDEVSFQDGDTIINVQQIDDGWMYGTVERTGDTGMLPANYVEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8C7</accession>
    <name>A0A151P8C7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eppin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0024397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000632">
        <property type="protein sequence ID" value="KYO45159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8C7"/>
    <dbReference type="eggNOG" id="KOG4295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586788" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO45159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="92" mass="9624" checksum="068D5D102D8A7A27" modified="2016-06-08" version="1">MKSGILLLLLAVPLLLWAKPTPPAEKAGYCSRQPPLGGVFDEEHCSACLKDQSCSNCSSDAKCPGEAKCCPGDCGFTCQAPVKALMASYDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P900</accession>
    <name>A0A151P900_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P900"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="100" mass="10955" checksum="70CB5F9CED579C2D" modified="2016-06-08" version="1">MERKGPREAAGFTPMAPQPCKSRGSGPNHLATRHGLATPEPAKPRKSHKLPSSPEICWCQMPIKDPKMSYIRSPKGSRNAELTLFSHLDKHLGSAQDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9D0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9982" checksum="5F2CB9C61C07538D" modified="2016-06-08" version="1">MGRATTTEAPGPWAKWLCKLDLAHGPQVAIPFGSERASASKCPHRQHWGIVNHWGHFTHVFTGWEGSVHDAHTFCNSPAPRADEEWALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9Z5</accession>
    <name>A0A151P9Z5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sister chromatid cohesion PDS5-like protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0021529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P9Z5"/>
    <dbReference type="eggNOG" id="KOG1525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P9Z5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001146">
        <property type="entry name" value="PDS5 cohesin associated factor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000064">
        <property type="entry name" value="Sister chromatid cohesion protein PDS5 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF2">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1171"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO45906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1355" mass="152900" checksum="A0397059A4729B14" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PA09</accession>
    <name>A0A151PA09_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021497</name>
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    <organism evidence="1 2">
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PA09"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9547" checksum="135B5725097F0530" modified="2016-06-08" version="1">MCWITFMDIVDQLAPHFEQQNIIAISLLTLEKQVTITIGKVTTRNNPCSVTNQFGMEVITGFYQMGFSNCVGAIDDIHIPILYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBQ1</accession>
    <name>A0A151PBQ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBQ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="8039" checksum="3966DE1D4DC2123E" modified="2016-06-08" version="1">MQQRMQEATQVQAAALFLKRHPASSRHRGAVGFLRVREEHKTITAQRWTLSQENSFLSKKCNVLKHPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCQ5</accession>
    <name>A0A151PCQ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCQ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="127" mass="13498" checksum="BB6B04C267848932" modified="2016-06-08" version="1">MRDRSTPRGRRELPARSLFRPIGKQLSARAASPGSPALSAVPRPWGPGPARRSPAAAAPTPTATGSARTRRAATATREASRRSEQIQLVVECASSSCQESISVHLMKDDVCDTVSQIHSLRGSLEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE65</accession>
    <name>A0A151PE65_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PE65"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="9578" checksum="5F15D732C4987A51" modified="2016-06-08" version="1">MRELLPVQSPGVATRDSYSTQVEFLQDPRMQWPLLTQGTDTEKMKRWFYKYLQQLFLNVERKDVHGQIFLLYSCCQAEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEE2</accession>
    <name>A0A151PEE2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEE2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7767" checksum="21DCFED4CBCE5DF1" modified="2016-06-08" version="1">MQEGPTDVNVHCPSSSTQDKMYPCFFLGYCGIQSPFRDKRYEQFWMVPGLSERTKGYELNIYQGNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ08</accession>
    <name>A0A151PJ08_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kunitz-type serine protease inhibitor vestiginin-7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0020492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000155">
        <property type="protein sequence ID" value="KYO48973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ08"/>
    <dbReference type="KEGG" id="amj:102568515"/>
    <dbReference type="eggNOG" id="KOG4597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000015">
        <property type="entry name" value="WAP four-disulfide core domain 6A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007587087" evidence="4">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO48973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="16121" checksum="6F277711522C51A8" modified="2016-06-08" version="1">MQRGSLFLLAEILTLWAGLQPASGQVSPDICKLPKEAGPCEMYILRFYYDLATRTCRPFVYGGCKGNENNFVSFLACLATCKIPDICRLPADPGPCKAYITRYYYDVATRTCKPFVYGGCEGNENNFGSSLICQLTCKIIGQLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ13</accession>
    <name>A0A151PJ13_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ATG7</name>
        <name evidence="15" type="ORF">Y1Q_0013928</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000123">
        <property type="protein sequence ID" value="KYO49009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ13"/>
    <dbReference type="STRING" id="8496.A0A151PJ13"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.100:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000156">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="14">
        <location>
            <begin position="124"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="450"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO49009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="815" mass="90607" checksum="48CE28A1AFAD631E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJC4</accession>
    <name>A0A151PJC4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000086">
        <property type="protein sequence ID" value="KYO49129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJC4"/>
    <dbReference type="STRING" id="8496.A0A151PJC4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF14">
        <property type="entry name" value="TRANSPORTER 2, ATP BINDING CASSETTE SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO49129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="197" mass="21443" checksum="0FA85471D6333E2E" modified="2016-06-08" version="1">MQVLMLYCGHQQIQDGIMTKGSLVSFLLYQGEVGDMYRWHWWGRSPCSSPAPCERTSTTGWSEEQVLAVARAACAAEFIATLDQGLETNVGEKSGQLSVGQKQRIAIARALIRLPGVLILDEATSALDVESETAVRAAVLSSRAHTVLVIAHRMATVEAADHIVVLERGAVAEQGTHSKLMAHQGPYYALVQRQLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJK9</accession>
    <name>A0A151PJK9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tumor necrosis factor receptor superfamily member 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TNFRSF1B</name>
        <name evidence="9" type="ORF">Y1Q_0001146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000161">
        <property type="protein sequence ID" value="KYO48965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJK9"/>
    <dbReference type="STRING" id="8496.A0A151PJK9"/>
    <dbReference type="eggNOG" id="ENOG502RZ23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151PJK9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043120">
        <property type="term" value="F:tumor necrosis factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005031">
        <property type="term" value="F:tumor necrosis factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097191">
        <property type="term" value="P:extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150079">
        <property type="term" value="P:negative regulation of neuroinflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051044">
        <property type="term" value="P:positive regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031643">
        <property type="term" value="P:positive regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048714">
        <property type="term" value="P:positive regulation of oligodendrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002724">
        <property type="term" value="P:regulation of T cell cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042129">
        <property type="term" value="P:regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051670">
        <property type="entry name" value="TNF_chemokine_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020411">
        <property type="entry name" value="TNFR_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47386">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47386:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01919">
        <property type="entry name" value="TNFACTORR1B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="5">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="8">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="8">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="5">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="8">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="5">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="5">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="8">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO48965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="467" mass="51137" checksum="FF74F7CB8E79C4CD" modified="2016-06-08" version="1">MRVEGNVLKYSLPYTPDELDTCKDPSTEYYEETIKKCCSKCHPGYHMDQICSTTLDTQCKRCGVNTYTEIWNRAPRCFGCSPACKNGTGLVQTRECTPTQDRACTCSANMYCSTKLHQKSCKHCKRHKKCQKGYGVSKPGTDTKDTICTPCPPGSFSDEESYTAPCRPHTVCKFVSIPGSFTSDTVCSDLPIGDLSTTIKAISPHTIVPATYQSPGQSLNFRTSDIKTRPVQQNIPLDVPQIGLMVGVTSLVFVAIAVAFFCFAFRKKGQICSHAVGDTNLPFSTEKQSDKKQRSLGVQGSSSSGQEEQHLLHTSGSSSSSLDNPTGSAKICTNNNKKVEKKDTHQKNLPSEGCKHHDEDRHNSASSEHSGNGGTQVNVTCIVKVCNSDHSSQFLDQMSSNTMDHENISNCTPTGETIPLSKEENPLKRETEIQLSVEAEDNLLQDLTFPEEKPFPLGIQDVGMKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZH2</accession>
    <name>A0A151LZH2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myotubularin-related protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0019422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006879">
        <property type="protein sequence ID" value="KYO17651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZH2"/>
    <dbReference type="STRING" id="8496.A0A151LZH2"/>
    <dbReference type="eggNOG" id="KOG1090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.200:FF:000004">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000006">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF16">
        <property type="entry name" value="C-MYC PROMOTER-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="2"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO17651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="956" mass="107036" checksum="2042953A3B553F1B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0L8</accession>
    <name>A0A151M0L8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0L8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13530" checksum="B79D25A5E4FFA2C6" modified="2016-06-08" version="1">MAKFSCLEKFILMVRQFHDGMITHSVDDSESPEAFPFTIRVKQGCVLASTLFSMMFSATLADPFHDCDPGIDIRYWTDGKLFNLRRLQEKMKLQEVTVHDLLFADNCSLNAKSKSDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0P1</accession>
    <name>A0A151M0P1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MCM6</name>
        <name evidence="15" type="ORF">Y1Q_0011678</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014454851.1">
        <property type="nucleotide sequence ID" value="XM_014599365.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0P1"/>
    <dbReference type="STRING" id="8496.A0A151M0P1"/>
    <dbReference type="GeneID" id="102575576"/>
    <dbReference type="KEGG" id="amj:102575576"/>
    <dbReference type="CTD" id="4175"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000091">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF73">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="344"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO18084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="822" mass="93018" checksum="B889C743EA1CB949" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1B8</accession>
    <name>A0A151M1B8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0012783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MHC class I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006834">
        <property type="protein sequence ID" value="KYO18301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1B8"/>
    <dbReference type="STRING" id="8496.A0A151M1B8"/>
    <dbReference type="eggNOG" id="ENOG502RQEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002474">
        <property type="term" value="P:antigen processing and presentation of peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000204">
        <property type="entry name" value="Major histocompatibility complex, class I-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF242">
        <property type="entry name" value="MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0490">MHC I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="212"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO18301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="351" mass="39682" checksum="6C0AB0D6FD01AB2A" modified="2016-06-08" version="1">MSILCGPPWEVAVSNGGPGICPLVLTITPAGSHRYQHFYMGVSDPSPGMPDFTARGYVDDQQILHYDSKTRRQEPRGDWVQRAVRPDFWDRETRSLQGWQGVFQSNLVTLRYRYNQTGGSHTLQFMYGCELHEHNSTGGHMLFGYDGEDFISYDLRTRTWVAAPTQAESTQSRWNKDKALLQDARSYLEETCIEWLRKYLQHGEAALQSKHPMAQVSDRPSQDGRTTLSCRVHDFYPRDVAVVWLKNGEVQPETNRAGVLPSGDGTYQTWATIEIDPSSNHNYTCSVEHESLGAALRVSWDKGQTESNWVLIMGITFGVLLVIATMSAVANFFCLREPAPSPEGPMEKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3K2</accession>
    <name>A0A151M3K2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Headcase protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HECA</name>
        <name evidence="5" type="ORF">Y1Q_0019019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3K2"/>
    <dbReference type="STRING" id="8496.A0A151M3K2"/>
    <dbReference type="eggNOG" id="KOG3816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026066">
        <property type="entry name" value="Headcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031947">
        <property type="entry name" value="Headcase_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054537">
        <property type="entry name" value="HECA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425">
        <property type="entry name" value="HEADCASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425:SF3">
        <property type="entry name" value="HEADCASE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16002">
        <property type="entry name" value="Headcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15353">
        <property type="entry name" value="HECA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584726" evidence="2">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Headcase N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Headcase middle" evidence="4">
        <location>
            <begin position="270"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO19097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="472" mass="53700" checksum="5BE2B784096AE176" modified="2016-06-08" version="1">MAFCFFNHVTTCLFLPAVPEAPCATPLICSFGRPVDLEKDDYQKVICNNEHCPYSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDDKKKKSVAEKSTGRSMGESAEDAKKGRPSNKPQKGLSHDIQRRHSMDRQNSQEKGVVSGGYAVRSPCGSPGQSPPTGYSILAPAHFSGPRSSRYLGEFLKNAIHLEPHKKNMAGGGMFRNAHFDYGAAGLQAHRSGHFDAPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSASHRNVVNCALCHRTLPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHLQGRLMHLYAVCVDCLEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIGMQYFSEYSNVQQCPHCGNLDYHFVKPFSSFKVLEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M611</accession>
    <name>A0A151M611_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM71E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM71E1</name>
        <name evidence="4" type="ORF">Y1Q_0016707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GARIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006523">
        <property type="protein sequence ID" value="KYO19921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M611"/>
    <dbReference type="STRING" id="8496.A0A151M611"/>
    <dbReference type="eggNOG" id="ENOG502S585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022168">
        <property type="entry name" value="GARIL-like_Rab2B-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22574">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22574:SF12">
        <property type="entry name" value="GOLGI-ASSOCIATED RAB2 INTERACTOR PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12480">
        <property type="entry name" value="GARIL_Rab2_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgi associated RAB2 interactor protein-like Rab2B-binding" evidence="3">
        <location>
            <begin position="15"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO19921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="158" mass="17349" checksum="11017C16ADD4B1D0" modified="2016-06-08" version="1">MGPCTTAPSSRATSSRMLPLQFVHLSIHSEDRYQLKVRLASGRTFYLQLLAPLAQLEQIFSQWVRLLYRLRYQCPGAVPRAKGTRDIPVPQGKGRGGRKAEPAPSKLKPSEKPAAQASKLSRASKLSRASIVSRASTVSLPSEPDSSDQSFLSEKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M661</accession>
    <name>A0A151M661_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridylate-specific endoribonuclease</fullName>
            <ecNumber evidence="11">4.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0009480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ribonucleotidyl-uridine-RNA = a 5'-end dephospho-uridine-RNA + a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA</text>
            <dbReference type="Rhea" id="RHEA:67792"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17354"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173117"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ENDOU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03006443">
        <property type="protein sequence ID" value="KYO20002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M661"/>
    <dbReference type="STRING" id="8496.A0A151M661"/>
    <dbReference type="eggNOG" id="KOG2849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21159">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PLACENTAL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439:SF43">
        <property type="entry name" value="URIDYLATE-SPECIFIC ENDORIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="EndoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51959">
        <property type="entry name" value="ENDOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026373198" description="Uridylate-specific endoribonuclease" evidence="11">
        <location>
            <begin position="19"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="EndoU" evidence="12">
        <location>
            <begin position="33"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO20002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="307" mass="34698" checksum="AF7D96C486002E06" modified="2016-06-08" version="1">MMKALLALLCLLPCFGHGAHFTFLGRNSGLSISDQELQHVSEELYAADVNRATGHQIILDLQHKVPASETSTGHDYASHKLFRYVDEGTLFTRPTFARLQALLDNYDRQTGQKEVVTATEAEEQEAFLAEIFATPVLATLTRFFLAKGLYASEAEFQEDLKTMWFGMYSRSSGKATDSSGFEHVFHGEIKKGKVSGFHNWVHYYELEKTGQINYLSYSYDGPWTAYPDILAIQYRWNSYLKSVGSLFIGSSPEFEMAVYTLCFKARPDRLCTLSLAGKRAQIQTYSWANTEYGPGRHYLASSYPFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7U5</accession>
    <name>A0A151M7U5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006377">
        <property type="protein sequence ID" value="KYO20510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7U5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="138" mass="14825" checksum="3905D0D5E57F0296" modified="2016-06-08" version="1">MGNVYERAGATVSFVVRPPRVLSRVLARRTGLLAGLDVSSRTCISLPSLLSEGRVTVGPEGEADKTADGQALATKERRTPHLPSGTERSCCCHTQVPGGQLEKKEQKQEKKARDLEVSGQSNNNRSKKLHLAAGAFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9M2</accession>
    <name>A0A151M9M2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase 6</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MAPK6</name>
        <name evidence="16" type="ORF">Y1Q_0001483</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9M2"/>
    <dbReference type="STRING" id="8496.A0A151M9M2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07854">
        <property type="entry name" value="STKc_MAPK4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000136">
        <property type="entry name" value="mitogen-activated protein kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000223">
        <property type="entry name" value="Mitogen-activated protein kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008350">
        <property type="entry name" value="MAPK_ERK3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01771">
        <property type="entry name" value="ERK3ERK4MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO21214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="628" mass="71918" checksum="C742852A6AEE93B9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAL2</accession>
    <name>A0A151MAL2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">protein-lysine 6-oxidase</fullName>
            <ecNumber evidence="12">1.4.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOXL1</name>
        <name evidence="16" type="ORF">Y1Q_0001726</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24544"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:12448"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:131803"/>
            <dbReference type="EC" id="1.4.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>lysine tyrosylquinone residue</name>
            <dbReference type="ChEBI" id="CHEBI:20489"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysyl oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.13" evidence="12"/>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAL2"/>
    <dbReference type="STRING" id="8496.A0A151MAL2"/>
    <dbReference type="GeneID" id="102576140"/>
    <dbReference type="KEGG" id="amj:102576140"/>
    <dbReference type="CTD" id="4016"/>
    <dbReference type="eggNOG" id="ENOG502QWET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547291at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004720">
        <property type="term" value="F:protein-lysine 6-oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001695">
        <property type="entry name" value="Lysyl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019828">
        <property type="entry name" value="Lysyl_oxidase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF8">
        <property type="entry name" value="LYSYL OXIDASE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01186">
        <property type="entry name" value="Lysyl_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00074">
        <property type="entry name" value="LYSYLOXIDASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00926">
        <property type="entry name" value="LYSYL_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0886">LTQ</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584927" description="protein-lysine 6-oxidase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO21555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="618" mass="68971" checksum="1A56B3F2C3F906BE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCQ5</accession>
    <name>A0A151MCQ5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL51</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L51, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRPL51</name>
        <name evidence="9" type="ORF">Y1Q_0002890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258430.3">
        <property type="nucleotide sequence ID" value="XM_006258368.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCQ5"/>
    <dbReference type="STRING" id="8496.A0A151MCQ5"/>
    <dbReference type="GeneID" id="102568131"/>
    <dbReference type="KEGG" id="amj:102568131"/>
    <dbReference type="CTD" id="51258"/>
    <dbReference type="eggNOG" id="KOG4045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059330at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MCQ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019373">
        <property type="entry name" value="Ribosomal_mL51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10244">
        <property type="entry name" value="MRP-L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO22284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="123" mass="14590" checksum="2EA010BF90FC15BE" modified="2016-06-08" version="1">MLRAARALLWGRGPTAALAVSTNSLLRPRVREPPAHVQVDRWTEKRALFGVYDNVGILGNFQAHPKDLIRGPKWLRGWRGNELQRCIRKKKMVGDRMFDQDYKNLVKRIRFLYRRYNHTKLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCU8</accession>
    <name>A0A151MCU8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">T-cell surface glycoprotein CD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CD4</name>
        <name evidence="4" type="ORF">Y1Q_0002909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCU8"/>
    <dbReference type="STRING" id="8496.A0A151MCU8"/>
    <dbReference type="eggNOG" id="ENOG502S2HD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.900">
        <property type="entry name" value="transmembrane domain of human cd4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015274">
        <property type="entry name" value="CD4-extracel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021963">
        <property type="entry name" value="Tcell_CD4_Cterm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11422">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11422:SF0">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09191">
        <property type="entry name" value="CD4-extracel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12104">
        <property type="entry name" value="Tcell_CD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="84"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO22309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="551" mass="62567" checksum="87C0CD9B2FEAAA34" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDG6</accession>
    <name>A0A151MDG6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDG6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="134" mass="15596" checksum="CAF8E618AB57695F" modified="2016-06-08" version="1">MDCDPSLTVTQCWKDYTIAECIKNIRESLDEIKPLTMNARWKNLWRKAANDFCGFLKMQHKVEEITELGRRVGGEGFDDLQATEIEELIKFHTTKLNEEELEELIQSSTSDEHSEEEEVARKLQLTKKSLDKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDG9</accession>
    <name>A0A151MDG9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger and BTB domain-containing protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ZBTB11</name>
        <name evidence="11" type="ORF">Y1Q_0003092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006271834.1">
        <property type="nucleotide sequence ID" value="XM_006271772.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDG9"/>
    <dbReference type="GeneID" id="102563525"/>
    <dbReference type="KEGG" id="amj:102563525"/>
    <dbReference type="CTD" id="27107"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MDG9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18202">
        <property type="entry name" value="BTB_POZ_ZBTB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000633">
        <property type="entry name" value="Zinc finger and BTB domain containing 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001553">
        <property type="entry name" value="Zinc finger and BTB domain containing 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001897">
        <property type="entry name" value="Zinc finger and BTB domain containing 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000002">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001072">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001086">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000070">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048060">
        <property type="entry name" value="ZBTB11_BTB_POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF41">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN CONTAINING 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
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    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="214"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="642"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="757"/>
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    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="785"/>
            <end position="812"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="813"/>
            <end position="842"/>
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    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
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    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
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    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="522"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="438"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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    <evidence type="ECO:0000256" key="1">
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
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    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO22545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1047" mass="119044" checksum="378AB27E60CC6B28" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MES6</accession>
    <name>A0A151MES6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">THG1L</name>
        <name evidence="17" type="ORF">Y1Q_0010943</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer. Interacts with MFN1 and MFN2; functions as a guanyl-nucleotide exchange factor/GEF for MFN2 and also probably MFN1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="12"/>
    <dbReference type="EMBL" id="AKHW03006228">
        <property type="protein sequence ID" value="KYO22900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006257860.3">
        <property type="nucleotide sequence ID" value="XM_006257798.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MES6"/>
    <dbReference type="STRING" id="8496.A0A151MES6"/>
    <dbReference type="GeneID" id="102571463"/>
    <dbReference type="KEGG" id="amj:102571463"/>
    <dbReference type="CTD" id="54974"/>
    <dbReference type="eggNOG" id="KOG2721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="15">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="16">
        <location>
            <begin position="158"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="49"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO22900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="289" mass="33836" checksum="12615DA8044D65F2" modified="2016-06-08" version="1">MQLWALASGGRARLSGSVAAMAKSKFEYVRAFEADDVCLPNTWAVVRLDGRNFHRFSEQHGFTKPNDDRALHLMTKCAQTVMEELEDITIAYGQSDEYSFVFKKKSNWFKRRASKFMTHVVSQFSSSYVFYWKDYFKDQPLRYPPGFDGRVVLYPSNQNLKDYLSWRQADCHINNLYNTVFWMLVQRSGLTPVQAQNRLQGTLAGDKNEILFSEFNINYNNEPLLYRKGTVLIWQKVNEVTTKRIQFPKETEEKEVEVTRTRNKVVPLHCDIIGDQFWEEYPEILADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF04</accession>
    <name>A0A151MF04_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein AMBP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">AMBP</name>
        <name evidence="35" type="ORF">Y1Q_0005548</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="28">Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="30">I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of ITIH3/HC3 and bikunin. Interacts with TNFAIP6 (via Link domain).</text>
    </comment>
    <comment type="subunit">
        <text evidence="29">Monomer. Also occurs as a complex with tryptase in mast cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="31">Monomer. Homodimer. In plasma, it occurs as a monomer or dimer and in covalently-linked complexes with immunoglobulin A (IgA), ALB/albumin and F2/prothrombin. Chromophore-bound alpha-1-microglobulin interacts with the constant region of immunoglobulin A. Chromophore-bound alpha-1-microglobulin interacts with ALB with molar ratio 2:1 and 1:1; this interaction does not prevent fatty acid binding to ALB. Interacts with F2/prothrombin (via N-terminus) with molar ratio 2:1 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin. Interacts with NDUFAB1, a subunit of mitochondrial complex I. Interacts with FN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267615.1">
        <property type="nucleotide sequence ID" value="XM_006267553.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF04"/>
    <dbReference type="STRING" id="8496.A0A151MF04"/>
    <dbReference type="GeneID" id="102562951"/>
    <dbReference type="KEGG" id="amj:102562951"/>
    <dbReference type="CTD" id="259"/>
    <dbReference type="eggNOG" id="KOG4295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9949223at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22596">
        <property type="entry name" value="Kunitz_bikunin_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22597">
        <property type="entry name" value="Kunitz_bikunin_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000007">
        <property type="entry name" value="Alpha-1-microglobulin/bikunin precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000005">
        <property type="entry name" value="Pancreatic trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002968">
        <property type="entry name" value="A1-microglobln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029856">
        <property type="entry name" value="AMBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46676">
        <property type="entry name" value="PROTEIN AMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46676:SF1">
        <property type="entry name" value="PROTEIN AMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01215">
        <property type="entry name" value="A1MCGLOBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00179">
        <property type="entry name" value="LIPOCALIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="26" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="24" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="20" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="19" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="15 33" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="33">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585056" description="Protein AMBP" evidence="33">
        <location>
            <begin position="18"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="34">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="34">
        <location>
            <begin position="278"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00029383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00029474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00046983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KYO23085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="344" mass="38781" checksum="DA9D2011FF1DF6E1" modified="2016-06-08" version="1">MKFQGLLFILFLATASGTPIGDRDIQVQENFDPDRIYGKWYDIAIGTTCQWMKNYKDKFNMGTLVLEPGLTSDQISTTSTRLRQGVCTRVSGEYQKTNIPGKYTYHNPKWEVSIVSYVLHTDYDEYAIMLMEKKSNFGLTTTLKLYGRSPDVRESLIEEFRLLARELDIPDDSIFILMNKGECIPSETETESSRVRREVLPEEEGSAGGPLPTFTGHKEDFCRLNKDAGPCLGAITRHFYNSSSRACETFLYGGCLGNGNNFHSEKDCLQACRTEASCRLPIMPGPCQQQVKLWAFDASQDKCVMFNYGGCQGNGNKFYTEKECKEYCGAGQLEGDEEFMGLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF54</accession>
    <name>A0A151MF54_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ficolin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FCN2</name>
        <name evidence="15" type="ORF">Y1Q_0005578</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF54"/>
    <dbReference type="STRING" id="8496.A0A151MF54"/>
    <dbReference type="eggNOG" id="KOG2579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003823">
        <property type="term" value="F:antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001867">
        <property type="term" value="P:complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF433">
        <property type="entry name" value="FICOLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0176">Collagen</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="14">
        <location>
            <begin position="90"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO23129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="307" mass="33663" checksum="91C0D82F22C8535C" modified="2016-06-08" version="1">MVAAVFCKTEDSCPEVSIAGLSGSDKLTILRGCPGTAGAPGPKGEPGTAGLKGEKGAPGIPGKAGPAGMKGERGVAGPPGPKGITDLEDLFCRQGARNCKELLSRGNILSGWYTIYPHDCNAMTVLCDMDTDGGGWIVFQRRADGSVDFYRDWESYKRGFGNQLTEFWLGNDNIHLLTSFGENELHIDLRDFDNNYHFAKYKSFKVLGETEKYKLILGDFVGGDAGDSLSSHKNMVFTTKDRDNDPDPNNCAVTFKGAWWYNKCHLSNLNGLYHRGPHSSFADGVNWKTGQGYKYSYRLSEMKFRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGK8</accession>
    <name>A0A151MGK8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activator of heat shock ATPase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AHSA2</name>
        <name evidence="3" type="ORF">Y1Q_0002278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273811.2">
        <property type="nucleotide sequence ID" value="XM_006273749.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGK8"/>
    <dbReference type="STRING" id="8496.A0A151MGK8"/>
    <dbReference type="GeneID" id="102560269"/>
    <dbReference type="KEGG" id="amj:102560269"/>
    <dbReference type="CTD" id="268390"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF4">
        <property type="entry name" value="ACTIVATOR OF 90 KDA HEAT SHOCK PROTEIN ATPASE HOMOLOG 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO23641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="332" mass="37893" checksum="963F9AED1655609F" modified="2016-06-08" version="1">MAKWGQGDPRWIVEERADATNVNNWHWTERDATSWSRRKLRAVLAGLAVEGAAGRCEVRDVKQVDGEASCTCRRGRLFFFYDWRIRLAWTGTMKESGEKHKGYVEIPSLSEENEVDDTEINISKKKGEGDVLKDLMKTEGTVKVREALKEYLKALKTDFTLGMILPTKSTVGQELAVERKLNGSTMQDSVSPVGIKIPTVKILMKEMFASSAEELYSIFTTKELVQKFSKCPALIDAEKGGRLQLFNGCVTGEYVELLPPQRIVMKWRCRNWPDEHYATVALNFKDMATQTELQLELKGVPVCNEADTRQCWQKQYFEEIHILLQQSEVNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJ32</accession>
    <name>A0A151MJ32_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0023234</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJ32"/>
    <dbReference type="STRING" id="8496.A0A151MJ32"/>
    <dbReference type="KEGG" id="amj:102562539"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MJ32"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000357">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="125"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="306"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO24542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="479" mass="53979" checksum="63BB75B8AA690B1B" modified="2016-06-08" version="1">MATDSWALAVDEQEAAAESLSNLHLKEEKTKPDSNGAVVKADDNAEKTEDEEKEDRAAQSLLNKLIRSNLVDTTNQVEVLQRDPTSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPGNKYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRDCQMLLFSATFEDSVWKFAQKVVPDPNIIKLKREEETLDTIKQYYVMCNNRDEKFQALCNIYGAITIAQAMIFCHTRKTAAWLAAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAINMVDSKHSMNILNRIQEHFNKKIEKLDTDDLDEIEKIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKN7</accession>
    <name>A0A151MKN7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-2-glycoprotein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Apolipoprotein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Beta-2-glycoprotein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NTD5</name>
        <name evidence="18" type="ORF">Y1Q_0016234</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005938">
        <property type="protein sequence ID" value="KYO25098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKN7"/>
    <dbReference type="GeneID" id="102574323"/>
    <dbReference type="KEGG" id="amj:102574323"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5804959at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MKN7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000011">
        <property type="entry name" value="CUB and sushi domain-containing protein 3 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015104">
        <property type="entry name" value="Sushi_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF502">
        <property type="entry name" value="BETA-2-GLYCOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09014">
        <property type="entry name" value="Sushi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585271" description="Beta-2-glycoprotein 1" evidence="16">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="146"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO25098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="349" mass="38700" checksum="35935EF5681AADFD" modified="2016-06-08" version="1">MPHSAPLILALLCLLLPVGGNKAKGATQPGPCASWREESTTVNLANQTCQRKCRHDRDCLGRRQCLCDGACGLSCVIPGRSCSWPVKVENAKTHLVQDTHSFGALMEVTCQTGFIMGAGQGAALSRCQGDRRWSLTPPCRRDLSLASCGPPPDIDHGFHHGASYRAGQEVQYQCKRGYQLEGVDTLQCQENQEWSGPAPVCRSMFCPPPQAVAKGYLVAVKKAQYRAGEVIYYLCKRGLLMDGSNRVMCLQNGTWSPQPFCRARCEVPAKRSRVLYQGMKLWVQEIPEGLVQHGETVSFYCRNHNQTCSYLASTRCFDGVLPLPVCYNEPTWLQYTLYPKRVVSEIQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKR5</accession>
    <name>A0A151MKR5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005917">
        <property type="protein sequence ID" value="KYO25122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKR5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="125" mass="14346" checksum="DF61C6868FA21983" modified="2016-06-08" version="1">MKSNTNSCSHSNRHNNEKVLQQWARIQEICLLFKPDTSFLWDLAEGTQIHSPRRQNCHPPSQHLSQNSKARPSPPLPPPLHSCLMNYLWNSLDKKKTQRLDSEQLPTLLDSPVSYISEGVEECSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLU7</accession>
    <name>A0A151MLU7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0017073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MHC class I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005763">
        <property type="protein sequence ID" value="KYO25495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLU7"/>
    <dbReference type="STRING" id="8496.A0A151MLU7"/>
    <dbReference type="eggNOG" id="ENOG502SMNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF67">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="248"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO25495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="391" mass="43745" checksum="7310EE772FBB9829" modified="2016-06-08" version="1">MQHHVPRLPARGGHGRNRRRTHPVLELWALPFLQFQCQDLSPPPGAMAWALALWMCWGLLEAAAASGLHHLDILVTGADEEDGTHNYFMIAKLNNFVVANYRSNTQEVRPTKEWVKRALGADYVQQQTLEFQGYEKVSKVHRKRWMKLYNQTDGLHVEQVHVGCSLSGDVLGDQKFQYAYDGEDFISFDIQQLTWVAAVPVAFAQKMRWDNDETWTQFVQWYLKEKCLQTLKSLLQEGKAILAQRVSPTVSVSRKDATDGSASLSCHVRGFYPRPIHVLWVQEGGEILPETFTSGILPTANNTFYTWTSLEVGPASAMHRYACRVEHSSLPEPSLTWVPDKKVTLLPVVLAVLIIAGGMILIGSVLGCASVWIKKSAGIAQSGYTPASTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN32</accession>
    <name>A0A151MN32_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tumor protein D52 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TPD52-1</name>
        <name evidence="5" type="ORF">Y1Q_0003719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN32"/>
    <dbReference type="STRING" id="8496.A0A151MN32"/>
    <dbReference type="eggNOG" id="KOG4010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10000687at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF12">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO25932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="218" mass="23794" checksum="17545227B42E5675" modified="2016-06-08" version="1">MDSYEDYKSPFDFNAGVNRNYLYLSPNVNVSPPESPALKNSELLRSDSITEVGEDAAATVNMPEPLSEEEQEELRKELVKVEEEIQTLSQVLAAKEKHLAEIKRKLGISSLQELRENITKGWQDVTSTTAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEKVENLKSKVGGGKPAGGDFGEVLNSAANASATETIAEQTQEETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPR3</accession>
    <name>A0A151MPR3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPR3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585376" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11063" checksum="D0F63819100B69A8" modified="2016-06-08" version="1">MTGVLFFSSSLLCRTYAVFMPLEEKGEICHTSYSKTHCSKRNSRGGTQDLFVLVHLFPPVHIHAGVPWQRLRCLATASAGTGQIFYRHSIQLYGSRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPX3</accession>
    <name>A0A151MPX3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal transducing adapter molecule 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0019088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPX3"/>
    <dbReference type="STRING" id="8496.A0A151MPX3"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11964">
        <property type="entry name" value="SH3_STAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17000">
        <property type="entry name" value="VHS_STAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000009">
        <property type="entry name" value="Putative signal transducing adapter molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000086">
        <property type="entry name" value="signal transducing adapter molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035657">
        <property type="entry name" value="STAM1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047528">
        <property type="entry name" value="VHS_STAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF2">
        <property type="entry name" value="SIGNAL TRANSDUCING ADAPTER MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="9">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="210"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO26596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37230" checksum="C0759B514B7AACE9" modified="2016-06-08" version="1">MPLFTTNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMKRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAIELSLKEQRQQQTTLSNLYPSTSGLLTNHKHEGRKVRAIYDFEAAEDNELTFKAGELITILDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMVKAEKKTVQFSDEVQVETIEPEPEPVYIDEVSIIKILILAFDMFKPIKCNLLSLRAKAISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQ36</accession>
    <name>A0A151MQ36_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Lanosterol 14-alpha demethylase</fullName>
            <ecNumber evidence="22">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="39" type="primary">CYP51A1</name>
        <name evidence="39" type="ORF">Y1Q_0019129</name>
    </gene>
    <organism evidence="39 40">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="39 40" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>24,25-dihydrolanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:45960"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:45961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxy-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75079"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28113"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:87057"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:75080"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>32-hydroxy-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxo-24,25-dihydrolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75087"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:87057"/>
            <dbReference type="ChEBI" id="CHEBI:87060"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:75088"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>32-oxo-24,25-dihydrolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75083"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
            <dbReference type="ChEBI" id="CHEBI:87060"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:75084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 36">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="21">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 37">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="39">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="22"/>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQ36"/>
    <dbReference type="STRING" id="8496.A0A151MQ36"/>
    <dbReference type="GeneID" id="102567199"/>
    <dbReference type="KEGG" id="amj:102567199"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000027">
        <property type="entry name" value="lanosterol 14-alpha demethylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 36 37" id="KW-0349">Heme</keyword>
    <keyword evidence="14 36 37" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 38" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 36 37" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 37" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13 37" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7 38" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 38" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="38">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="36">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00041158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="EMBL" id="KYO26648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="500" mass="56196" checksum="4F13120E808B1A62" modified="2016-06-08" version="1">MATRSLLEAGGALLQRAAAGSPLSTALAAAAFVLGLGYLLQLGCRQRRPPPPAAGKPPPFIASPVPFLGHAVAFARSPIRFLEAAYETYGPVFSFTMVGKTFTYLLGSDAASLLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKTGLNIAQFKQHVRVIEKETKDYFNSWGQSGKRNLFEALSELIILTASHCLHGKEIRSLLNEKVAQLYADLDGGFTHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKVIQKRRQSGEREDDMLQTLLDVRYKDGHPLTDDEIAGMLIGLLLAGQHTSSTTSAWLGFFLARDKSIQEQCYVEQKAVCGDDLPPLSYDQLKDLNLLDRCLKETLRLRPPIMTMMRMARTPQTVAGYTIPPGHQVCVSPTVNHRLKDSWVEALEFKPDRYLQDNPAAGEKFSYVPFGAGRHRCIGENFAYVQIKTIWSTLLRLYEFDLIDGSFPTINYTTMIHTPNHPVIRYKRRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQR2</accession>
    <name>A0A151MQR2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQR2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="8456" checksum="F30BBB5C7B602E3A" modified="2016-06-08" version="1">MRRLVLSRKLHQPQAHEQKQFQNLESCTKWNCHNPDCSGTSILQGISQVSGAHRILSINIIFIRDIAKKICGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQU7</accession>
    <name>A0A151MQU7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fer3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FERD3L</name>
        <name evidence="7" type="ORF">Y1Q_0019230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQU7"/>
    <dbReference type="STRING" id="8496.A0A151MQU7"/>
    <dbReference type="GeneID" id="102576290"/>
    <dbReference type="KEGG" id="amj:102576290"/>
    <dbReference type="CTD" id="222894"/>
    <dbReference type="eggNOG" id="KOG4029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6125763at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MQU7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11415">
        <property type="entry name" value="bHLH_TS_FERD3L_NATO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000035">
        <property type="entry name" value="Pancreas-specific transcription factor 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF63">
        <property type="entry name" value="FER3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO26770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="161" mass="17796" checksum="496BC8889DFC3946" modified="2016-06-08" version="1">MARQEGLVGASVLGFVADLSLGSPAGPPRGAARLDLYELAPGPPFGDTALALRQGLPLSTFGDGDQEEEEEEEAAQRRGATALLDRPKRKRVITSAQRQAANIRERKRMFNLNEAFDELRKKVPTFAYEKRLSRIETLRLAIVYISFMTELLDSCSQEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRE2</accession>
    <name>A0A151MRE2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">SNF-related serine/threonine-protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">SNF1-related kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SNRK</name>
        <name evidence="24" type="ORF">Y1Q_0019387</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRE2"/>
    <dbReference type="eggNOG" id="KOG4717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14074">
        <property type="entry name" value="STKc_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14339">
        <property type="entry name" value="UBA_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000166">
        <property type="entry name" value="SNF-related serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF90">
        <property type="entry name" value="SNF RELATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="16"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="23">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="490"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00077142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO26979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="604" mass="67524" checksum="409ADFAA5E8A6F19" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTE8</accession>
    <name>A0A151MTE8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sperm-associated antigen 8 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SPAG8</name>
        <name evidence="1" type="ORF">Y1Q_0007561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005102">
        <property type="protein sequence ID" value="KYO27782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTE8"/>
    <dbReference type="STRING" id="8496.A0A151MTE8"/>
    <dbReference type="eggNOG" id="ENOG502S06E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026124">
        <property type="entry name" value="Sperm-assoc_Ag8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15510">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15510:SF5">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22584">
        <property type="entry name" value="CFAP143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO27782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="130" mass="14426" checksum="7659BFB10266A7F5" modified="2016-06-08" version="1">MGLYHGVSMFLVAQAGVTSRVACLPGEAVLLLCSALLCSARRATNELDQVPSPELGSEGIFYRHGHRGLLTPQQCACLADSTTMKDAYRRPVPTGLPQRGQREAMLELMLYHKYREETLREHCPRPAPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWH4</accession>
    <name>A0A151MWH4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitogen-activated protein kinase 4</fullName>
            <ecNumber evidence="5">2.7.11.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Extracellular signal-regulated kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0009744</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWH4"/>
    <dbReference type="STRING" id="8496.A0A151MWH4"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07854">
        <property type="entry name" value="STKc_MAPK4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000281">
        <property type="entry name" value="Mitogen-activated protein kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000136">
        <property type="entry name" value="mitogen-activated protein kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008350">
        <property type="entry name" value="MAPK_ERK3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01771">
        <property type="entry name" value="ERK3ERK4MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="10"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO28901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="570" mass="65815" checksum="314FC03F60C5A522" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWH6</accession>
    <name>A0A151MWH6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0009709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>urea(in) = urea(out)</text>
            <dbReference type="Rhea" id="RHEA:32799"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urea transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWH6"/>
    <dbReference type="STRING" id="8496.A0A151MWH6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464:SF4">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO28852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="221" mass="24783" checksum="808C5D65E2D721C9" modified="2016-06-08" version="1">MELGPDWHSGLIIIAGLLIQNPWQTLTGCLGTTVSALTALILGQDSPVLSSALGSIFSKWDLPIFTLPFNVTVSLYLAATGRYNLFFPTTSIQPVTSVPNSTWSELHTQLAFTPRCLTKVKKKCCHTTQIKYQQPVERKIKSYRQKEASAETWEELKMANELQEGYQNPIILGFAIDDNPGVHSKSCLTALTWKSYREKIETHQAQQQRLTWSESCHGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWW7</accession>
    <name>A0A151MWW7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWW7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="12903" checksum="35E1B5FBF06FA4BC" modified="2016-06-08" version="1">MDKVWKDSEYPWSKKQNGNARDRVYMKHWNKIEKSGSCGRCRELLRQFHSRPGGRDDLNEILTELKSISKLILTAVGPGFHSGYMQSPEWTVYRKQSLITSLKKRMKKGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX06</accession>
    <name>A0A151MX06_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX06"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="8276" checksum="9B46AA26810F6D6B" modified="2016-06-08" version="1">MQSWKSEWSTLPTGLKDKSCQRAGHGVFPIDVWRSNMEVVRPMNSAVWNVFFHNDSCSVSQVSALVSADQEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX30</accession>
    <name>A0A151MX30_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyadenylate-binding protein-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAIP1</name>
        <name evidence="7" type="ORF">Y1Q_0009870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX30"/>
    <dbReference type="STRING" id="8496.A0A151MX30"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000016">
        <property type="entry name" value="polyadenylate-binding protein-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF15">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="6">
        <location>
            <begin position="90"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO29064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="406" mass="45683" checksum="93B0A15F0FE7AFE1" modified="2016-06-08" version="1">MAPGSQQQEPLRPPKTAPPGTGLAGTAAPRSPRPQGPPAGPAVAKPQVAVAPVIMSKLSVNAPEFYPPGYNPNFTDSSFEDGCDAYSTLTDYVQDFLIHLTEQPGCFETEIEQFADTLNSWVTTDEALQELVELIYQQATSVPNFSYMGARLCNYLSHHLTINPQSGNFRQLLLQRCRTEYENRDQAAKGDEATRKQFHAFVLFLAELYLNLEIKGTKGQVTRAEILQVGLRELLNALFSNPVDNNLICAVKLLKLTGSVLEDAWKEKGKTDMDEMIQRIENVVLDAHCSRDVKQMLLKLVELRSSNWGRVHVTSTYREATPENDPNYFMNEPTFYTSEGVPFTAADPDYQEKYQELLEREDLFPDYEENGTDLSGAGDPYFDDMDDEMDPEIEEAYEKFCLESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXS4</accession>
    <name>A0A151MXS4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0017994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXS4"/>
    <dbReference type="STRING" id="8496.A0A151MXS4"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MXS4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF19">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO29363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="370" mass="42757" checksum="4ECF89B1D0F968E3" modified="2016-06-08" version="1">MGSHCGPAPLPGAEGPDGIPFPRRLPRPLARLRQQSSSSNTIENGFKVSEEPLLRKNPRRFVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWNKLKSEEKYFISHILAFFAASDGIVNENLVERFSQEVQIPEARCFYGFQILIENVHSEMYSLLIDTYIKDPEKREFLFNAIETMPCVKKKADWALRWIADRDSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFHYLVNRPLEERVKEIIVNAVEIEQEFLTEALPVGLIGMNCTLMKQYIEFVADRLLVELGFSKFFYAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYL7</accession>
    <name>A0A151MYL7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium channel subunit beta-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SCN4B</name>
        <name evidence="12" type="ORF">Y1Q_0017306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004630">
        <property type="protein sequence ID" value="KYO29600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYL7"/>
    <dbReference type="STRING" id="8496.A0A151MYL7"/>
    <dbReference type="eggNOG" id="ENOG502QTZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086002">
        <property type="term" value="P:cardiac muscle cell action potential involved in contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000920">
        <property type="entry name" value="Myelin_P0-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869">
        <property type="entry name" value="MYELIN P0 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869:SF14">
        <property type="entry name" value="SODIUM CHANNEL SUBUNIT BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO29600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="241" mass="25869" checksum="7B9A7129B009CF49" modified="2016-06-08" version="1">MPQLSCLGEVFPFTGSAALTGLLRSRDCQSQAAKIKGLYMCAVAVALEVSVGKTNVVTALNGSDVLLPCVFTTCIGFWDLVFTWSYNDSTTLCRGFIKSKAVEPKVQSENFRVVFVGSTTGKDNNISIVLLSVDFSDAGKYTCHVKNPREKGNAEHSSYIELQVVHKLVVADNTLTLIIVAVVGGLIGLLILFMVVKKVVLFIIKKTQDGKKECLVSSSGNDNTENGLAGSKAEQKVTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZ39</accession>
    <name>A0A151MZ39_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">WNT5B</name>
        <name evidence="12" type="ORF">Y1Q_0023150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZ39"/>
    <dbReference type="STRING" id="8496.A0A151MZ39"/>
    <dbReference type="eggNOG" id="KOG3913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19347">
        <property type="entry name" value="Wnt_Wnt5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF33">
        <property type="entry name" value="PROTEIN WNT-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO29782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="395" mass="44221" checksum="8E161145872AF4AA" modified="2016-06-08" version="1">MAEACAVREPRQRSIGILMQRGALGTAGSTMASKYLIVALAIFSSFTQVVIEASSWWSLGMNPMNPMNPVQMPEVYIIGAQPLCSQLAGLSQGQKKLCQLYQDHMQFIGEGAKTGIKECQYQFRHRRWNCSTVDNNSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSSCGCSRAARPKDLPRDWLWGGCGDNIEYGYRFAKEFVDARERERLYQRGSYESARIMMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNTRGKLVQVNSRFNAPTIHDLIYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQRERCHCKFHWCCYVKCKLCTEVVDQFVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N107</accession>
    <name>A0A151N107_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TEKT5</name>
        <name evidence="14" type="ORF">Y1Q_0008166</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sperm-specific microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellar axoneme. Forms an extensive interaction network in different conformations that reinforces the helix bundle composed by other tektin proteins (TEKT1 to TEKT4) and MIPs to anchor the tektin bundle onto the tubulin wall of A-tubule of the sperm flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Microtubule inner protein component of sperm flagellar doublet microtubules. Interacts with TEKT3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">Cytoskeleton</location>
            <location evidence="12">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N107"/>
    <dbReference type="STRING" id="8496.A0A151N107"/>
    <dbReference type="eggNOG" id="KOG2685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151N107"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF23">
        <property type="entry name" value="TEKTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 12" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO30506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="362" mass="42147" checksum="75D8BFBF588C6947" modified="2016-06-08" version="1">MQDKDQLTQQMQDDTGTNMGQRLSDIEFWRSELIYELQRLLTDTRALDTAKKRLECAADETEGPLKIALECLYNREKRMGIDLVHDDVEKNLIKEVDMFKSCQERMRKLAERIDQQLGINRDAQHALERDLSDKSSAHFIDEKCYNLRNTSDSIKFYHGIEKIDGTVSVPQTWARFSDDNIRNSQNARANSAKLCEEMENVLENTSEEMWKQYTDTNLAFDHRISEIGDIKNKLQAHLAKTLQEIFQIENTIMLLERSIMAKECPLKVAQTRLEGRTRRPNIELCCDIPQFKLVNEVFTIGDTLQTLKQRLRDAQDTLQLLVLNKSRLEHDVSVKANSFFIDKKCMDMRKTFPSTPRLIGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N147</accession>
    <name>A0A151N147_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase CPPED1</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Calcineurin-like phosphoesterase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CPPED1</name>
        <name evidence="13" type="ORF">Y1Q_0008196</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. CPPED1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N147"/>
    <dbReference type="STRING" id="8496.A0A151N147"/>
    <dbReference type="eggNOG" id="KOG1378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07395">
        <property type="entry name" value="MPP_CSTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041867">
        <property type="entry name" value="MPP_CSTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051918">
        <property type="entry name" value="STPP_CPPED1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43143:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE CPPED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO30546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="289" mass="33000" checksum="90B79C4302B4A0A9" modified="2016-06-08" version="1">MRGFRQDEEYQWKAPFYFIQGADPQFGLMKAWAIGDCDSGGDEWEEEIKLTEQAVQAINKLNPKPKFFVLCGDLIHGMPGTQWRKDQEQDLKNVLKKVDQDIPLVFVSGNHDIGNAPTPETIDDYCKHWGDDYFSFWIGGVFFLVLNSQLYFNSSKCPELKQAQDEWLNGQLAIAEKQKCKHVIVFQHIPLFLKDPDEDHDYFNLEKSVRHNIMEKFQKAGIKAVFSGHCHKNAGGFYKGLEMVVSSAIGCQLGEDTHGLRVVIVTEEDIVHRYYSLNELSNQGIGASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1H4</accession>
    <name>A0A151N1H4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SUN domain-containing protein 1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SUN1</name>
        <name evidence="10" type="ORF">Y1Q_0008298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus inner membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1H4"/>
    <dbReference type="STRING" id="8496.A0A151N1H4"/>
    <dbReference type="eggNOG" id="KOG2687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21439">
        <property type="entry name" value="SUN1_cc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000009">
        <property type="entry name" value="SUN domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032680">
        <property type="entry name" value="SUN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040994">
        <property type="entry name" value="Sun_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF23">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18580">
        <property type="entry name" value="HTH_SUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09387">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="9">
        <location>
            <begin position="698"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="860" mass="97349" checksum="EECF424787EE0A2B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N349</accession>
    <name>A0A151N349_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N349"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10526" checksum="E63217063D1C75E3" modified="2016-06-08" version="1">MPFCFHQENLSSLKRGNELWNSLFPVCPGTRPLFSHKQLRGMKADQPEPAFQAAQLPIVNAAQSPALAAYHLASDECCCVHCGFDDVLLDRTVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N377</accession>
    <name>A0A151N377_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gypsy retrotransposon integrase-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0016986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004108">
        <property type="protein sequence ID" value="KYO31274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N377"/>
    <dbReference type="STRING" id="8496.A0A151N377"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="269"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO31274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="396" mass="44639" checksum="5208BF8B3C3925CE" modified="2016-06-08" version="1">MYLEIGVLKEAPVSISVGSDIMELGHLKGAWGCFIKPYGMNVVTQQQSRKMKAGGGETSQGLVTPLAVEAKGEKGETPPGCDHQPATEETGDLEVGLRDSPEEKPGQLVVEETETLRQKLENTPPGEGALLTGAPELPMDCLPGQEELKQEALVDPSLEELRQMAQEFTPDKREQMVWDKGLLYRLWEPRNHAKSWEPCYQLVVPLTFRKKLLSMARDLSCTGYMGRDQTFQRLQANFYWPRLAQNVMDYRSSCETCERTGKRGDKRKPPLQPLPIIDQAFQRVRIDVVGPLRHKTCRGKQYILTFVYFKTRYLEAVALASTEAPVVADTLTKIFFQLGFPSEILTDRGGNFLAEVMKCLWECCGVQDHCLSLSDKWASKEVQWDLERYTEGLCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4A9</accession>
    <name>A0A151N4A9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Methylenetetrahydrofolate reductase (NADPH)</fullName>
            <ecNumber evidence="11">1.5.1.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MTHFR</name>
        <name evidence="17" type="ORF">Y1Q_0006048</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:19819"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.53" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4A9"/>
    <dbReference type="STRING" id="8496.A0A151N4A9"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000003">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="16">
        <location>
            <begin position="296"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO31465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="601" mass="68926" checksum="B3F74BA96CAA5016" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N515</accession>
    <name>A0A151N515_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM47E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM47EL</name>
        <name evidence="3" type="ORF">Y1Q_0012157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004011">
        <property type="protein sequence ID" value="KYO31923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N515"/>
    <dbReference type="eggNOG" id="ENOG502QRUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032743">
        <property type="entry name" value="FAM47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46449:SF5">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 47 MEMBER E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46449">
        <property type="entry name" value="ZGC:158260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14642">
        <property type="entry name" value="FAM47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO31923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="439" mass="49905" checksum="70D9E9910B42C84B" modified="2016-06-08" version="1">MNLGSSFTCKLVHPKVPGKKMPLKCIRENKLKFSDSLNSRRWTFLKNGLDDFRDGFPPPSDNNIIHGTKGPVPILQHNSASNASCMAQPKGRKRCTKTQISPCKLSPLQKARRDYISQIEYCVSQHPLVLYPHLEESVPPELFKEVMDVLDPEMCLSCEAGCKDHEQENHAPQKEQYLLEDGQRKKTTPVPRSSVLIFKRKEFRGKNSYTRLSKKEVAARERAARLNYIPPLDENIKQITKEFCDWVTSLGGEKYNMDEATILSMFDTGYETKLTISVPIHVVELNNVPAELRKCLGVSPPQTSAKSPLNAGCHPCYAKDPSQTKWEKIRYGAWYLDPKTWRKQKANETLEAPKAPVDSFQNMKMRLNGKEAEVIQLHGTYAFKEFLERKGYRKPEFLLKMLAATSATGTQEGSSKSHRKEHLKRHEGLREGSSSTIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N525</accession>
    <name>A0A151N525_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004011">
        <property type="protein sequence ID" value="KYO31933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N525"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="113" mass="12767" checksum="0C880D06092A4930" modified="2016-06-08" version="1">MCGASLQEDKISVWRCCCNSCVVHLFVHQMSLQIADRRGKGYLHFLGRMVWEFTQWRCGRECMQLGVGIPTDYRSPGAPKAMRGITGLMVPPAAMEYQRHQRAELLCGSPCCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5K2</accession>
    <name>A0A151N5K2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004011">
        <property type="protein sequence ID" value="KYO31977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5K2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="11205" checksum="8FE8116FF7252B91" modified="2016-06-08" version="1">MAGSQKELSSVWARYTLHQGKAPEKNCLKDDTLCMCHLCQWQTQDKNLMLGQLVTALEEQLMDSQAWQAQDVDYEQETGWVYLALKERIPFKLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N742</accession>
    <name>A0A151N742_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Rab11 family-interacting protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">RAB11FIP3</name>
        <name evidence="24" type="ORF">Y1Q_0020365</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Recycling endosome membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N742"/>
    <dbReference type="STRING" id="8496.A0A151N742"/>
    <dbReference type="GeneID" id="102571765"/>
    <dbReference type="CTD" id="9727"/>
    <dbReference type="eggNOG" id="KOG0982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418358at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2440:FF:000001">
        <property type="entry name" value="RAB11 family interacting protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000227">
        <property type="entry name" value="Rab11 family-interacting protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057316">
        <property type="entry name" value="Rab11-FIP3/4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF6">
        <property type="entry name" value="RAB11 FAMILY-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25450">
        <property type="entry name" value="Rab11-FIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="FIP-RBD" evidence="23">
        <location>
            <begin position="515"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO32409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="577" mass="65923" checksum="955DDE267F648D93" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8F5</accession>
    <name>A0A151N8F5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine-triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">THTPA</name>
        <name evidence="3" type="ORF">Y1Q_0023904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003852">
        <property type="protein sequence ID" value="KYO32879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8F5"/>
    <dbReference type="STRING" id="8496.A0A151N8F5"/>
    <dbReference type="eggNOG" id="ENOG502S5G9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151N8F5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050333">
        <property type="term" value="F:thiamine triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042357">
        <property type="term" value="P:thiamine diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039582">
        <property type="entry name" value="THTPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14586:SF1">
        <property type="entry name" value="THIAMINE-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="36"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO32879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="281" mass="30068" checksum="4C5DA61BD53EA9EB" modified="2016-06-08" version="1">MTPPPSHCKACWEPSLHFNSALDADMQEDVAEPTGSIEVEAKFMVGPGTEARLVVLGAVLAGAVSFQDQYYDTPDGRLTLADHWLRHREGAGWELKCPPWPAGGARDPGYGPGATSQDGSTRAATSLNPGAPAQPPGSTTAYQELTSPAAVVARLCAILAVAPDPGWACIPVAVAGLGLEVFAAFRTQRRSYRLGRLSVDLDEADFGYAVGEVETAVTHPWEVPAAQEEVTRVGRELGVEVTGPVMGKMSVYLQQYRPQHYEELVQAGRLVRDKMPMGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAP3</accession>
    <name>A0A151NAP3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SLC16A14</name>
        <name evidence="5" type="ORF">Y1Q_0024512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAP3"/>
    <dbReference type="STRING" id="8496.A0A151NAP3"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF239">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="58"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO33893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="373" mass="41076" checksum="96BC406F74805D63" modified="2016-06-08" version="1">MRAPGLQRAPRGPPARNCENTVEKMYSSREDIQEDDSNDNKKTLKPNSNIDGGWAWMIVLSSFLVHILIMGSQMALGILNMEWLEEFSQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRKTAIIGGIVNATGWILSAYASNVHYLFITFGVTAGLGSGMVYLPAVVMVGQYFQKKRALAQGLSTTGTGFGTFLMTVLLKYLCMEFGWRNAMFIQGAISLNLCVCGALMRPLSYQDEANEKVTERNSSEDNYVKALSPSAETLKSNGVLNEELEKKEGLTNDEVFDTVQTIESKVGTKHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGMLYLVGIIFLLIQPCIQKKEPREKHTENAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBA3</accession>
    <name>A0A151NBA3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intraflagellar transport protein 172 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IFT172</name>
        <name evidence="12" type="ORF">Y1Q_0011015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003609">
        <property type="protein sequence ID" value="KYO34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NBA3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000008">
        <property type="entry name" value="Intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000012">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000013">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="10">
        <location>
            <begin position="267"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="616"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1389" mass="157617" checksum="909A20ED23BC10B6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBL7</accession>
    <name>A0A151NBL7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">TCDD-inducible poly [ADP-ribose] polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TIPARP</name>
        <name evidence="14" type="ORF">Y1Q_0024603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBL7"/>
    <dbReference type="eggNOG" id="ENOG502QQXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000008">
        <property type="entry name" value="TCDD-inducible poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000003">
        <property type="entry name" value="TCDD-inducible poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF7">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE TIPARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23466">
        <property type="entry name" value="WWE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="12">
        <location>
            <begin position="339"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="13">
        <location>
            <begin position="462"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="705" mass="80589" checksum="91015A3A27BECE9F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDF4</accession>
    <name>A0A151NDF4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
            <ecNumber evidence="3">3.1.3.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Inositol polyphosphate 5-phosphatase J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">INPP5J</name>
        <name evidence="21" type="ORF">Y1Q_0009675</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57895"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="EC" id="3.1.3.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19797"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.3.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19798"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:22765"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EC" id="3.1.3.56" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03003322">
        <property type="protein sequence ID" value="KYO34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDF4"/>
    <dbReference type="STRING" id="8496.A0A151NDF4"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09094">
        <property type="entry name" value="INPP5c_INPP5J-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000003">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041611">
        <property type="entry name" value="SKICH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF127">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 5-PHOSPHATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17751">
        <property type="entry name" value="SKICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="20">
        <location>
            <begin position="150"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="571"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="728"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="780" mass="86184" checksum="C657DF9CD5815FE8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDW8</accession>
    <name>A0A151NDW8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SH2 domain-containing adapter protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SHB</name>
        <name evidence="7" type="ORF">Y1Q_0000890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDW8"/>
    <dbReference type="eggNOG" id="ENOG502QTRD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000021">
        <property type="entry name" value="Putative SH2 domain-containing adapter protein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF31">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING ADAPTER PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="348" mass="38920" checksum="3FDD659A8D26D11B" modified="2016-06-08" version="1">MSSQVPTYSPYPSHSERRPATPPDIKYISPKHRLIKIDSAGDSAPACKGAWSPPAAAAKKLNKCPEPPEGAVPCAKKEKVLIADDYSDPFDAKSELNKAGKGENTGYMEPYEAQRIMTEFQRQESVKSQQKGIQLYDTPYEPEGNGVESDSESVVSQRLRESKLPQDDDRPADEYDQPWEWNKVTIPALAAQFNGNEKRQSSPSPSSDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAIPLEKQIWYHGAISRTDAENLLRLCKECSYLVRNSQTSKHDYSLSLKSSQGFMHMKLTKTKEKYILGQNSPPFDSVPEVIHYYTTKKLPIKGAEHLSLLYPVAVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFB4</accession>
    <name>A0A151NFB4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Interferon regulatory factor 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lymphocyte-specific interferon regulatory factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NF-EM5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">IRF4</name>
        <name evidence="15" type="ORF">Y1Q_0008050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019345865.1">
        <property type="nucleotide sequence ID" value="XM_019490320.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFB4"/>
    <dbReference type="STRING" id="8496.A0A151NFB4"/>
    <dbReference type="GeneID" id="102577255"/>
    <dbReference type="KEGG" id="amj:102577255"/>
    <dbReference type="CTD" id="3662"/>
    <dbReference type="eggNOG" id="ENOG502QUE4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8537190at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NFB4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00103">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000041">
        <property type="entry name" value="Interferon regulatory factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000005">
        <property type="entry name" value="Interferon regulatory factor 4 deltaE6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019817">
        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019471">
        <property type="entry name" value="Interferon_reg_factor-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF6">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10401">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01243">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00601">
        <property type="entry name" value="IRF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="14">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="446" mass="51103" checksum="AB14F1E67174BF76" modified="2016-06-08" version="1">MNLEGGECGMTSVSCGNGKLRQWLIDQIDSGKYPGLVWENDEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLSMEDQPLMMNHPFPMASPYTSLQPQVSNYMLPHERNWREFAPEQHPDIPYQCTGVPFATRGHPWQGPACESGCQVTGTFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYRETLVKEVTTSNPEGCMISHGQNYEVNGLDQVIFPYPEDNAQRKNIEKLLNHLERGVILRMAPDGLYAKRLCQSRIYWDGPLALCSDRPNKLEREQTSKLFDTQQFLAELQAFAHHGRPLPRFQVALCFGEEFPDPQRQRKLITAHVEPMFARQLYYFAQQNSGHFLRGYEPIPEHVTSPEDYHRSISHSSIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFG4</accession>
    <name>A0A151NFG4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glutamate decarboxylase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0008084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFG4"/>
    <dbReference type="STRING" id="8496.A0A151NFG4"/>
    <dbReference type="eggNOG" id="KOG0629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009449">
        <property type="term" value="P:gamma-aminobutyric acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO35527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62965" checksum="879E2240AA30AD18" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG08</accession>
    <name>A0A151NG08_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG08"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11188" checksum="E277780FF7D826D6" modified="2016-06-08" version="1">MSGAICGESPPVRHRTVTGAPYCYSFPGAPMNQRRWEVGTHVDEERPHCKRLSHSADQELTFPDSYQPSPGAHSCSRHFCWLKKGLSIFGAKNPFQTKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG44</accession>
    <name>A0A151NG44_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Toll/interleukin-1 receptor domain-containing adapter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIRAP</name>
        <name evidence="3" type="ORF">Y1Q_0010203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275664.2">
        <property type="nucleotide sequence ID" value="XM_006275602.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG44"/>
    <dbReference type="SMR" id="A0A151NG44"/>
    <dbReference type="STRING" id="8496.A0A151NG44"/>
    <dbReference type="GeneID" id="102563698"/>
    <dbReference type="KEGG" id="amj:102563698"/>
    <dbReference type="CTD" id="114609"/>
    <dbReference type="eggNOG" id="ENOG502S07Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9424455at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035663">
        <property type="term" value="F:Toll-like receptor 2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035662">
        <property type="term" value="F:Toll-like receptor 4 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000343">
        <property type="term" value="P:positive regulation of chemokine (C-X-C motif) ligand 2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017279">
        <property type="entry name" value="Tol-interleuk_rcpt_adapt_Tirap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22662">
        <property type="entry name" value="TIRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22662:SF0">
        <property type="entry name" value="TOLL_INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="74"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO35781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="230" mass="25772" checksum="720ADD2832766A70" modified="2016-06-08" version="1">MAGWLKRVLQKPKQSSNSRSSSTATPTRSPSSSTSSPVRSSSSSASSSVLHPRSPLTSASQVNISSSGSARWTKSYDVCICHNEGDFAFVEEMVSYLESQPETFRCFLQMRDATPGSAIVTELCEAVQNSHCWVMVITPGFLQDPWCRYQMHQALAEAPMANGRTIPVLKDIDRKDYPRELRCLYYIHVTFKENGFRQIKDTVLRYLQELCQSAPSTTERLESCKRKGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGB2</accession>
    <name>A0A151NGB2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hemopexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HPX</name>
        <name evidence="15" type="ORF">Y1Q_0017200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the hemopexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003099">
        <property type="protein sequence ID" value="KYO35827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGB2"/>
    <dbReference type="STRING" id="8496.A0A151NGB2"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000009">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051298">
        <property type="entry name" value="Heme_transport/Cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22917:SF9">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22917">
        <property type="entry name" value="HEMOPEXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="109"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="13">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO35827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="460" mass="50624" checksum="D1A416C680841023" modified="2016-06-08" version="1">MRGSPPLPRGQHWRGGSGGPGTNGAALHRGRSSPGTGPPKKPGASHGSRCGDESLNDTDTLRRCADDGAFDAVTLDEKGRMLFFKGDEVWKGSHGRPEPINATWPELGSGPVDTAFRIHHKSSSVHDSLYLFQGEQVWVYTDGKLRSGYPRAIGDEFKGVPGHLDSAVECHPEECQAEGIIFFKGSDVYWYDLSAGQLKQRAWTQVGNCSAALRWLERYYCFQGLNFLRFNPVSGDVPAHRYPLDSRDYFICCPGRGHGHAAHHNATLHAPMDRCSGLPLQAFASDDKGRLYAFRKGYYFRLDSRRDGWHAWPLSHRWAGLEGEVDATFMWENFMYVIQGSKVFIYREDQGHALMQDYPKGLQEELGIPGADAAFTCPGSPLLYIIQGSSMQEVDLGNSQRVPKPAVPIPHSHVDSATCTADGVYLFHDAVFYHYPDAASLAGASAPAAPQITATVFFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGI8</accession>
    <name>A0A151NGI8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thrombospondin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0020686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003039">
        <property type="protein sequence ID" value="KYO35922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGI8"/>
    <dbReference type="STRING" id="8496.A0A151NGI8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000038">
        <property type="entry name" value="thrombospondin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024665">
        <property type="entry name" value="TSP/COMP_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046970">
        <property type="entry name" value="TSP/COMP_CC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199">
        <property type="entry name" value="THROMBOSPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199:SF89">
        <property type="entry name" value="THROMBOSPONDIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11598">
        <property type="entry name" value="COMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58006">
        <property type="entry name" value="Assembly domain of cartilage oligomeric matrix protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO35922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="226" mass="24678" checksum="DA2F356070649D1D" modified="2016-06-08" version="1">MVNVAHKIRTELLTVNDAYLLSTFRLPPKQGGVLFGLYSKKDNTRWLEVSVVGKINKVLLRYLREDGKLHVVNLQHTGLADGRSHTVIVRLSGLRADALSVELYVDCKQADASAGLPQIAVVPQAELEAVEVRTGQKAYQRLQGFIESMKLILGGSMSRVGALSECPFQGDESIHSAVTGVLNSILGEQTKALVTQLTLFNKVLMELREDIRDQCPFPPTPSGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGM5</accession>
    <name>A0A151NGM5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Roundabout-like protein 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ROBO2</name>
        <name evidence="22" type="ORF">Y1Q_0010229</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the immunoglobulin superfamily. ROBO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NGM5"/>
    <dbReference type="eggNOG" id="KOG4222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022603">
        <property type="term" value="P:regulation of anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07693">
        <property type="entry name" value="IgC_1_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000053">
        <property type="entry name" value="Roundabout guidance receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000055">
        <property type="entry name" value="roundabout homolog 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000065">
        <property type="entry name" value="roundabout homolog 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000026">
        <property type="entry name" value="roundabout homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000043">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000058">
        <property type="entry name" value="roundabout homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF236">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586049" evidence="19">
        <location>
            <begin position="30"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="869"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="39"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="141"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="322"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="426"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="533"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="647"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="744"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1028"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1146"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1157"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1174"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1240"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1275"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1295"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1324"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1369"/>
            <end position="1389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO35809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1406" mass="153659" checksum="22DF8F4D05F44389" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHQ8</accession>
    <name>A0A151NHQ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 6-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit E-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">EIF3L</name>
        <name evidence="4" type="synonym">EIF3EIP</name>
        <name evidence="4" type="synonym">EIF3S6IP</name>
        <name evidence="7" type="ORF">Y1Q_0024104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259021.1">
        <property type="nucleotide sequence ID" value="XM_006258959.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHQ8"/>
    <dbReference type="STRING" id="8496.A0A151NHQ8"/>
    <dbReference type="GeneID" id="102572830"/>
    <dbReference type="KEGG" id="amj:102572830"/>
    <dbReference type="CTD" id="51386"/>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NHQ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="331"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO36346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="564" mass="66722" checksum="FF26F407A667F740" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK33</accession>
    <name>A0A151NK33_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Golgi-associated olfactory signaling regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GFY</name>
        <name evidence="2" type="ORF">Y1Q_0008423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK33"/>
    <dbReference type="STRING" id="8496.A0A151NK33"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586125" evidence="1">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="130" mass="14376" checksum="1F7AE7CFCABB9A18" modified="2016-06-08" version="1">MGLFLGACGLLLCLLAGVYCAYCRAARKELFTHHCLQDATFDDLVLHLEAPKDSYDWFYYDTEYEVPPPAPRLPVQAQSQMAPTLPSACPVLLKPPKDEALGPPGQEQPKLRPLKLECLSPASLPQGNYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLX6</accession>
    <name>A0A151NLX6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ER membrane protein complex subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">EMC9</name>
        <name evidence="2" type="ORF">Y1Q_0017142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002569">
        <property type="protein sequence ID" value="KYO37832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLX6"/>
    <dbReference type="STRING" id="8496.A0A151NLX6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF12">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="141" mass="15909" checksum="5A2D5FC2DE2B7124" modified="2016-06-08" version="1">MLDVALHQLSAPPAQHATTLRGNKTASPPPLAQRVAGRLAELCEGAVLIMLNNRKFTMSPRVPPILVLEQRDRQWVPKDKNLVMWQDWESSRRVCQTLLEAKAYTQLVDFDAHLDDIRRDWTNQQLNAEIAQLMSVANGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMN8</accession>
    <name>A0A151NMN8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002540">
        <property type="protein sequence ID" value="KYO38087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMN8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="9053" checksum="1AD54919C18A426B" modified="2016-06-08" version="1">MASRRFLTIPLQEGIATPFLSLTIIPSFLLLPTIKSDVLTRMLNKKIVSSWCLSWKKKELHKTRNFMCGVYTQYGVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NN17</accession>
    <name>A0A151NN17_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002540">
        <property type="protein sequence ID" value="KYO38039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NN17"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7464" checksum="6313EFC41B51F32B" modified="2016-06-08" version="1">MEEEEERLVWRRGVVMEEKESLERRCGTTKETDKEKGIGEPTDGRLDPDSRASHGLDNPPLVPGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPQ8</accession>
    <name>A0A151NPQ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPQ8"/>
    <dbReference type="STRING" id="8496.A0A151NPQ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="587" mass="66686" checksum="FEC7A27D71B94D88" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQD8</accession>
    <name>A0A151NQD8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Embryonal Fyn-associated substrate isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EFS-1</name>
        <name evidence="8" type="ORF">Y1Q_0023896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002411">
        <property type="protein sequence ID" value="KYO38930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQD8"/>
    <dbReference type="STRING" id="8496.A0A151NQD8"/>
    <dbReference type="eggNOG" id="ENOG502QUFB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000009">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021901">
        <property type="entry name" value="CAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037362">
        <property type="entry name" value="CAS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654">
        <property type="entry name" value="CAS SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654:SF14">
        <property type="entry name" value="EMBRYONAL FYN-ASSOCIATED SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12026">
        <property type="entry name" value="CAS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO38930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="392" mass="41558" checksum="03A9127194E21951" modified="2016-06-08" version="1">MCARLARALYDNVAECPEELSFRRGDLLVLLQPAAPGPAGWHLCALHGQPGIVPANRVRLLPEPGPLDPSPGPTSAGLHEGPGRRSHEPPEDKKEEEEQGVYVVPPPARPCPLPLDAIYNVPRGARRDGDPGEVYAVPSSLPSAPYDLPPTREGPEGQEGEQDETYAAPPGSLRRAPALPDLYEAPEDVLGGLAEGDGPNEYEGIRLPDEYDYVHLKQGTDRSQPPNMDQPTPKDLLGPGIEPETPPLPKEEEEVPRPGPEDAQLLQFYAGQCQGHYTALQAAMAALLTSAEAQEPPGTFVPHGKRVIVTAHKLVFVGDTLARLASSAPVRAHVGAAAGALCQALREAVLAVKGAALSYPSASAARLLRQRVAELARRALAFTSLLGALAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQV4</accession>
    <name>A0A151NQV4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRPM SLOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002375">
        <property type="protein sequence ID" value="KYO39123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQV4"/>
    <dbReference type="STRING" id="8496.A0A151NQV4"/>
    <dbReference type="KEGG" id="amj:109283096"/>
    <dbReference type="eggNOG" id="KOG3614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF6">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRPM SLOG" evidence="1">
        <location>
            <begin position="91"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="428" mass="45699" checksum="F1B07EEB72CD52AE" modified="2016-06-08" version="1">MTSIKRQDQAWIPKLFKKKTCTSFVEAPPAPGAPSMCQCGNPRDKHVSVAVEDAFGASIVSKWDSAQHTTEQPTDAYGEVEFMGTWGKPSKFIRVSDSTDPAAAYSLVTCCWKIPPPNLVVSVVGGDSDIAIRTQLKDMLRKGLVKAAQSTGAWIMTGGLQAGIGRYVGEAVRDHATASTSPSARVVAMGIAPWGMVANQDQLINPKGSFPARYVRPLPTPEATCTALPLDSNHSAFFLVDNGTHGHPGGQNRFRTRLEGHIAQQCVGTSGQGSIQIPVLVMLIGGDASMFTRVLEAVQASIPCLLVGGSGGVADCLAQVLAETQPGEPVRALAQEKMQDRFPPNDLLHLAEQVENIMALRDLVTVYSDEEGVDEFETILLKALVKGETTPLPDSQQDLLLGHLVLGPRQHVPLPTPLQVPSEGLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRR9</accession>
    <name>A0A151NRR9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0004814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002337">
        <property type="protein sequence ID" value="KYO39165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRR9"/>
    <dbReference type="STRING" id="8496.A0A151NRR9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40710">
        <property type="entry name" value="RIKEN CDNA E230025N22 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40710:SF1">
        <property type="entry name" value="RIKEN CDNA E230025N22 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="51"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="590"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO39165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="695" mass="77199" checksum="12AFD7EB5CC41805" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRS9</accession>
    <name>A0A151NRS9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TOP3B</name>
        <name evidence="11" type="ORF">Y1Q_0018598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006269379.1">
        <property type="nucleotide sequence ID" value="XM_006269317.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRS9"/>
    <dbReference type="STRING" id="8496.A0A151NRS9"/>
    <dbReference type="GeneID" id="102561328"/>
    <dbReference type="KEGG" id="amj:102561328"/>
    <dbReference type="CTD" id="8940"/>
    <dbReference type="eggNOG" id="KOG1957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000002">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="171"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="818"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="818"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO39494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="862" mass="96826" checksum="BD10432F33860CCE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSY4</accession>
    <name>A0A151NSY4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0006690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSY4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO39810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="10170" checksum="7854B9D31F0DB6B9" modified="2016-06-08" version="1">MPMTEGVVAVNTGPFVLQERSIHDQHVVEAVVGPGTLSTCVSKSTRPLQACERIYRSSDAAGQAAHKKGSLCLHSPPVVGVSSFPKGEALKLRTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUV9</accession>
    <name>A0A151NUV9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0020554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001915">
        <property type="protein sequence ID" value="KYO40657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUV9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000271">
        <property type="entry name" value="Zinc finger protein 662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO40657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="255" mass="27218" checksum="6CE2FD297FE5EC0F" modified="2016-06-08" version="1">MEVNSVEELANGEDSQKGIMGLSGRQGLIPLVMEVSGGEQLASEEESQQSTTGVSARQGFLPGIVEVNGIKRLGAERVRSQGDVLGLSARPGLLPLVVKVSGIEGLANGEPSPVDNLAAGRAAIIAINGLANRKAVAATAGEDLHTTELLQEPIRSLGPAPWAPLPAPRPLPPTVAKRYRCKDCGKTFIHSSSLSRHRRRHARDQPYPCRDCWLGFSTPGRLQQHQRAGCGDATYPCPGHTPDLLRPPELPQLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVQ9</accession>
    <name>A0A151NVQ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0004203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001820">
        <property type="protein sequence ID" value="KYO40878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVQ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012836742" evidence="2">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO40878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="9012" checksum="0EDEA3138D744F34" modified="2016-06-08" version="1">MVLLGLWLWRDLCRGKRVVSEKKEENARKEEKSEEREIPQGGAGSVDKKTLLWGGVEGLMVLGQAKQGFLLRITLNTCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWF1</accession>
    <name>A0A151NWF1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Interleukin-27 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IL27</name>
        <name evidence="2" type="ORF">Y1Q_0019594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001719">
        <property type="protein sequence ID" value="KYO41053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014457024.1">
        <property type="nucleotide sequence ID" value="XM_014601538.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWF1"/>
    <dbReference type="STRING" id="8496.A0A151NWF1"/>
    <dbReference type="GeneID" id="106739389"/>
    <dbReference type="KEGG" id="amj:106739389"/>
    <dbReference type="CTD" id="246778"/>
    <dbReference type="OrthoDB" id="9446539at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NWF1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045523">
        <property type="term" value="F:interleukin-27 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042129">
        <property type="term" value="P:regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026207">
        <property type="entry name" value="IL-27_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20879">
        <property type="entry name" value="INTERLEUKIN-27 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20879:SF1">
        <property type="entry name" value="INTERLEUKIN-27 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586423" evidence="1">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="199" mass="21730" checksum="2852CDE7C7A4488B" modified="2016-06-08" version="1">MRTLGLAVVLSALLGAGGSRPPPPPRWALGLGPEFRSSWKLAQKLLVETRELTRDFVLRHLPGVQLQLLPLSEQLLPGSLRTRDWLGLTVLARLQGLGAALPQYRGALARLGLPGGDPEFAQRLQDVDWDLRDLAHHVAYQLSVARAPAAPPPRPPPPAPRAVWRRLQATAVTLRSLEAVLARAARDFALLRRLVPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYU9</accession>
    <name>A0A151NYU9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Z-DNA-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ZBP1</name>
        <name evidence="4" type="ORF">Y1Q_0002695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340042.1">
        <property type="nucleotide sequence ID" value="XM_019484497.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYU9"/>
    <dbReference type="STRING" id="8496.A0A151NYU9"/>
    <dbReference type="GeneID" id="106737676"/>
    <dbReference type="CTD" id="81030"/>
    <dbReference type="OrthoDB" id="9837317at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NYU9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060340">
        <property type="term" value="P:positive regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042371">
        <property type="entry name" value="Z_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042361">
        <property type="entry name" value="ZBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14966">
        <property type="entry name" value="Z-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14966:SF0">
        <property type="entry name" value="Z-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02295">
        <property type="entry name" value="z-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00550">
        <property type="entry name" value="Zalpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50139">
        <property type="entry name" value="Z_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Z-binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Z-binding" evidence="3">
        <location>
            <begin position="105"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO42047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="436" mass="47142" checksum="C9949D4F702B4368" modified="2016-06-08" version="1">MAKAASREASEVKQRILDYLRAAETPKKAMEVASGCSITKREANNALYTLHKEGQVQKQEGGKWVVCADGTELESCCKTPQPAAADTALVPWGRRGNAVVPARNNSGLTETQDRMYTYLHENGPQRALSIAKHLGKQTQKDVNPDLYALMKKHLLHFNEEQKLWSCYSKGADYKATGPEVKSHITYILQANPINNICLPGDHSAVHISHSTATQIGHNNTANVMDKNDDCNPTVWSSPCSTKTAKTSYDDSEAKAAMPCDQDIQVTESVLRNVLVGNQNQMDVIKTDVVDSPAEQVGQCGTSEKDSFGQIPSSRSSFSLHNSTPSRTGGTSSQRLGIDKSTLDNVMIGNANQMSVRDGIAFADLADLSANKDDDTSDSDSTSNEAERISGDDNNLDQSSDISILCATLKNTVLGNNNNLNIVELVDSESDSENGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZY7</accession>
    <name>A0A151NZY7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZY7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7939" checksum="6374AA1ED2267932" modified="2016-06-08" version="1">MRSVTGPHVVEELMKWIVQTDALERAMLWKLSPRERRSHEDKDRKEPGVANIDPVMLRTPNMSTPNVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0B1</accession>
    <name>A0A151P0B1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cell division cycle and apoptosis regulator protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cell cycle and apoptosis regulatory protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CCAR1L</name>
        <name evidence="17" type="ORF">Y1Q_0022304</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0B1"/>
    <dbReference type="STRING" id="8496.A0A151P0B1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell division cycle and apoptosis regulator protein 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CCAR1/CCAR2"/>
    </dbReference>
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        <property type="entry name" value="DBC1/CARP1_inactive_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="S1-like_RNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR14304">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304:SF14">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14443">
        <property type="entry name" value="DBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14444">
        <property type="entry name" value="S1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01122">
        <property type="entry name" value="DBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="17" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SAP" evidence="16">
        <location>
            <begin position="531"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="180"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="495"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO42474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="600" mass="69248" checksum="E1697038CFC30318" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0Q5</accession>
    <name>A0A151P0Q5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein TBATA isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TBATA-1</name>
        <name evidence="2" type="ORF">Y1Q_0022271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="8496.A0A151P0Q5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037394">
        <property type="entry name" value="TBATA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33772:SF3">
        <property type="entry name" value="PROTEIN TBATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33772">
        <property type="entry name" value="THYMUS, BRAIN AND TESTES-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15256">
        <property type="entry name" value="SPATIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="339" mass="37570" checksum="9CEA353E1454290E" modified="2016-06-08" version="1">MEMSKSPVVAPFKGIDITGVSGKLEHMALNTPLRFSVEALRPQSKSTSRFGSFSHHSFFSRHNPHPHRVTHIQGLNGVPICMVNDGWSRLTPLPSHPMIKGQLSTTILGAPGIQLPIGDPHSNLVPRLGSLSEAWREELKELAARVSAASCKEMEKKEVISKTEELRRATQYSAETGRLIPPPSRANTRHSFHQMHGNNAKNKGKEAVLSFQDQELVILELLCQILQTDSLMAIQEWLLTAGQREKDLVMGMLQTATASLQLEPQSLTTNTEERPQTQISQITAGLPSRGHHLGRSSSTRFSHKKKQEPIPEEEKPVHIGTAEVLQFHSSQQNQPDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3U9</accession>
    <name>A0A151P3U9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3U9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO43425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="172" mass="19632" checksum="117BD8B49222F322" modified="2016-06-08" version="1">MEFDWNNGGPAASQGGEATFGSRDAASGSLIPTARALQMLQLCQRRTFLLDHLVTALEDWQADTWAWWEEGVAHQDRLWAEDITHEDKWDQREEAWDQANPEFQAQLLALKHEQENTLQEQNDIMTGQCKPWTMTTRSSNEAVCKQFTIQLANLHPSLSPIERKPLRVVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4L6</accession>
    <name>A0A151P4L6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001003">
        <property type="protein sequence ID" value="KYO43986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4L6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="8424" checksum="F97734DF693FDF65" modified="2016-06-08" version="1">MVERVEWVASSQTRSRRWQRSVTSTSQDQLLASWAGWTGEEDSDGLVPCRPARLCSDYLLRGLISNSRTWSIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5U7</accession>
    <name>A0A151P5U7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0016754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000764">
        <property type="protein sequence ID" value="KYO44447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5U7"/>
    <dbReference type="STRING" id="8496.A0A151P5U7"/>
    <dbReference type="KEGG" id="amj:102572311"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P5U7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO44447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="447" mass="51712" checksum="DB12A1267EF07125" modified="2016-06-08" version="1">MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKTQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7K9</accession>
    <name>A0A151P7K9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7K9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="77" mass="8461" checksum="85673ED255E86259" modified="2016-06-08" version="1">MEVFDWTSRGTCRSGLRISKSTFSQHIISEPSRINLNMAEPQVMLAHTTGIKVKKTMPVDFSSTGITGAFQHASHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7M4</accession>
    <name>A0A151P7M4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase p58-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7M4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase p58-like C-terminal" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="321" mass="37190" checksum="04DBF96E79848098" modified="2016-06-08" version="1">MEDPDMAAYASAQPMLVSVLEALGQNLQALTQIVGTQQQMLGQQQEWFRQGQASFRMPKMTKDDDPEAYIEAFERHALMTSLPQKHWASQLGALVVGVAQAAYRAIPREEARDYEQVKQAILYRLEFSPDYYRHLFRAKKRPDKRRPWVLLQLLRDLLDKWNIARENLRDAQALQKERYDSNTRERVFEPGQLVLVLLPTSTSQFLMQWQGPFEILRRVGPVDYEVHRPGHRREKQIFHVNLLREWKEPTGWVTFVEAEGEDLGPQGQQREGTLSDEIQQLIGVGEDLSELQKQETRKIFLCSGPLALVHVLWPAFSTQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7N7</accession>
    <name>A0A151P7N7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0007344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7N7"/>
    <dbReference type="STRING" id="8496.A0A151P7N7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586767" description="Immunoglobulin V-set domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="3">
        <location>
            <begin position="46"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO45034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="180" mass="20404" checksum="C81D62DF5B636629" modified="2016-06-08" version="1">MQGKLLALLFSLACLSPGVMMNQGSRETYPHFSTTVLLTGTNLNLSLVFNVEWSFLLDGTEESGVTILTFSPSSHRKIITDGYKERVVFSETDFSLQINHFTSSDEGIYVLNIQVHEGDPQISRTKIKVISVSSWTSYGFFGYPGYLGYIVISFYIFLLIRRIWKSSKTQPECIYENIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P807</accession>
    <name>A0A151P807_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM84B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM84B</name>
        <name evidence="3" type="ORF">Y1Q_0014640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P807"/>
    <dbReference type="STRING" id="8496.A0A151P807"/>
    <dbReference type="GeneID" id="102572570"/>
    <dbReference type="KEGG" id="amj:102572570"/>
    <dbReference type="CTD" id="157638"/>
    <dbReference type="eggNOG" id="ENOG502QSKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6157531at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P807"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043299">
        <property type="entry name" value="LRATD1_LRATD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46341">
        <property type="entry name" value="PROTEIN FAM84B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46341:SF2">
        <property type="entry name" value="PROTEIN LRATD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRAT" evidence="2">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="280" mass="31640" checksum="67B0CA55AFC44F53" modified="2016-06-08" version="1">MGNQVEKLTHLSYKEVPTADPAGAERDDGPRIGVSYIFSTDDEELEPGQEAGGGEQQPYDPRLHELECSVYYRDECIYHKGFSPPDAAAADLSTYSAEHLLSRCQPGDLVEFVCPAQYPHWAVYVGDFQVVHLQRLEVLSSFLTDASQGRRGRIANALYRYPALSPAAVVRNALEQVGCKERELSWRNSECFAAWCRYGRREFKIGGELRIGKQPYRLHLRLGQRRAHTLEFQSLEDLIMEKRRNDQLGRAAVLQELAAHLQADEEDGEEEEEAVEGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P823</accession>
    <name>A0A151P823_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine-rich repeat-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LRRC6</name>
        <name evidence="12" type="ORF">Y1Q_0014660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tilB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P823"/>
    <dbReference type="STRING" id="8496.A0A151P823"/>
    <dbReference type="GeneID" id="102571292"/>
    <dbReference type="CTD" id="23639"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000052">
        <property type="entry name" value="Leucine rich repeat containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056496">
        <property type="entry name" value="CS_DNAAF11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23602">
        <property type="entry name" value="CS_DNAAF11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 11-like CS" evidence="11">
        <location>
            <begin position="264"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="394"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO45198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="475" mass="55904" checksum="17FDFED67985EADF" modified="2016-06-08" version="1">MVRVTEDLVRRRAEHNNCEIFSLEEITLHQQEIEKIEYLDKWCRDLKILYLQNNLIPKIENVSKLKKLEYLNLALNNIERIENLEGCEELQKLDLTANFIGELSSIEVLKHNMHLKELFLMGNPCTEFEGYRQFVVATLHQLKCLDSKEIERSERIQALQNYAEIKKKIREQEQAYCLRRAREKEEVVQKIQERQKKKKDKPNPGFDRRWYTDINNTIPDPLQDKENQQHTEEENEYRQWGADEDNEEDRAFWEEPTLYTPESRLETHRYIEEKRRAKEDLRGHKKKEKPPRTLITTEGKVLNINEPKLHFSLKDDEENNQFILDLAVYRHMDTSLIDVDVQPTYIRVMVKGKPFQLVLPAEVKPDSSSSKRSQTTGHLVINMPKAKDIIMANRKAPASAKPSDSNKSQTNTRRRQQVEQLEVDPNKYSFPDVANIVQEKERTGKGPIRLQQHKAIEPEKSFTDSVDGEDVPPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8B0</accession>
    <name>A0A151P8B0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Signal peptide, CUB and EGF-like domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SCUBE3</name>
        <name evidence="15" type="ORF">Y1Q_0023054</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000602">
        <property type="protein sequence ID" value="KYO45331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8B0"/>
    <dbReference type="STRING" id="8496.A0A151P8B0"/>
    <dbReference type="GeneID" id="102561628"/>
    <dbReference type="CTD" id="80274"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000510">
        <property type="entry name" value="Signal peptide, CUB and EGF-like domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000024">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000032">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000002">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000199">
        <property type="entry name" value="signal peptide, CUB and EGF-like domain-containing protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000006">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000028">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000030">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000035">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000002">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000124">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF4">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586777" description="Signal peptide, CUB and EGF-like domain-containing protein 2" evidence="12">
        <location>
            <begin position="31"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="353"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="831"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO45331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1021" mass="112969" checksum="51B57F34B59C0230" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8Y2</accession>
    <name>A0A151P8Y2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras and Rab interactor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RIN3</name>
        <name evidence="11" type="ORF">Y1Q_0015151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIN (Ras interaction/interference) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8Y2"/>
    <dbReference type="STRING" id="8496.A0A151P8Y2"/>
    <dbReference type="GeneID" id="102570647"/>
    <dbReference type="KEGG" id="amj:102570647"/>
    <dbReference type="CTD" id="79890"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16130">
        <property type="entry name" value="RA_Rin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.80:FF:000002">
        <property type="entry name" value="Ras and Rab interactor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF58">
        <property type="entry name" value="RAS AND RAB INTERACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23268">
        <property type="entry name" value="RIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="58"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="10">
        <location>
            <begin position="690"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="868"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO45492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="963" mass="107257" checksum="0FA7D7C046199E8B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAR7</accession>
    <name>A0A151PAR7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein FRG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FRG1</name>
        <name evidence="14" type="ORF">Y1Q_0021647</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAR7"/>
    <dbReference type="STRING" id="8496.A0A151PAR7"/>
    <dbReference type="eggNOG" id="KOG3962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23338">
        <property type="entry name" value="beta-trefoil_FSCN_FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000031">
        <property type="entry name" value="FRG1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO46070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="225" mass="25274" checksum="619534334591990B" modified="2016-06-08" version="1">MRRGLNGGRKRRGNWWAVSNFGEITGSVAIEMDKGAYIHALDNGLFTLGAPHKDDDGPSPPEQFTAVKLSDTRIALKSGYGKYLGINSEGLVIGRSDAIGSREQWEPVFQDGRMALLAANSCFIRCNEEGDIEAKSKMAGEEEMVKIRTCAERETEKKDDIPQEDKGNVKQCEVNYVKKFQSFQDHKLKISQEDAKALKKARKEGTFHETLLDRRAKLKADRYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAZ0</accession>
    <name>A0A151PAZ0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase D</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">40 kDa peptidyl-prolyl cis-trans isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cyclophilin-40</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Rotamase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PPID</name>
        <name evidence="16" type="ORF">Y1Q_0021797</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Identified in ESR1 or NR3C1/GCR steroid receptor-chaperone complexes. Found in HSP90 chaperone complexes with kinase clients LCK or EIF2AK1. Two monomers associate with one HSP90 homodimer. Interacts with HSP90AA1. Interacts with HSP90AB1; PPID and FKBP4 compete for binding to HSP90AB1 and the interaction is mutually exclusive with the PPID:HSPA8 interaction. Interacts with HSPA8; PPID and STIP1 but not FKBP4 compete for binding to HSPA8 and the interaction is mutually exclusive with the PPID:HSP90AB1 interaction. Interacts with S100A1 and S100A2; the interactions dissociate the PPID:HSP90AA1 interaction. Interacts with S100A6. Interacts with MYB, ILF2, XRCC6, RACK1 and RPS3. Interacts with cytoplasmic dynein 1 intermediate chain (DYNC1I1 or DYNC1I2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261512.2">
        <property type="nucleotide sequence ID" value="XM_006261450.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAZ0"/>
    <dbReference type="STRING" id="8496.A0A151PAZ0"/>
    <dbReference type="GeneID" id="102562702"/>
    <dbReference type="KEGG" id="amj:102562702"/>
    <dbReference type="CTD" id="5481"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6 14" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="15">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO46266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="370" mass="40683" checksum="BD97CF5FA2D0C53F" modified="2016-06-08" version="1">MSHPCPDPKSASPSSPRAFFDVDVGGERVGRIVFELFADIVPKTAENFRALCTGEKGLGLTTGKSLHYKGCPFHRIIKKFMVQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKAGLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVVKLLENVEVNGENPAKLCIIAECGELKEGDNWGILPVDGSGDIHPDFPEDSETDFREVDKIVSIAEDIKNIGNTFFKSQNWAMAAKKYHKGLRYLEASEAVIEEVDKAKLKTPALTCILNVAACKLKQSDWQGTIENCSEALAIDPGNTKALYRRAQAWQGIKDFDQALADIKKAQEIAPEDKAIQTEILKIKQKIKAQKDKEKAAYAKMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBI8</accession>
    <name>A0A151PBI8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0006955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000504">
        <property type="protein sequence ID" value="KYO46402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBI8"/>
    <dbReference type="STRING" id="8496.A0A151PBI8"/>
    <dbReference type="eggNOG" id="KOG4006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF40">
        <property type="entry name" value="ANTI-PROLIFERATIVE PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO46402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="8992" checksum="EEB8C10B26221C44" modified="2016-06-08" version="1">MKAEISTAAGFITRLLRSPGGIGDEQLRCFGDCLQEALRDHYRHHWFPQMPSKGSGYRCIRINHKMDPLIGKAAGVLPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBK3</accession>
    <name>A0A151PBK3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBK3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="100" mass="11158" checksum="90EFC2DD35C6B293" modified="2016-06-08" version="1">MVPTPIWSTIASGSPLSVAAVGGQTPLRALLQKSSLPVQAMRYIIWIQFPVLPQICHVTLKINYGNRKQIPISVNISVNSRLPWIKDFAKNLSVLLFEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PC71</accession>
    <name>A0A151PC71_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein 827</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ZNF827</name>
        <name evidence="22" type="ORF">Y1Q_0021866</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, HNRNPK and HNRNPL. Interacts with the nucleosome remodeling and histone deacetylase/NuRD complex. Interacts with RBBP4; the interaction is direct and recruits RBBP4, a component of the NuRD complex, to telomeres.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PC71"/>
    <dbReference type="STRING" id="8496.A0A151PC71"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000272">
        <property type="entry name" value="Zinc finger protein 827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000415">
        <property type="entry name" value="Zinc finger protein 827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000435">
        <property type="entry name" value="Zinc finger protein 827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002599">
        <property type="entry name" value="Zinc finger protein 827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000484">
        <property type="entry name" value="zinc finger protein 827 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001564">
        <property type="entry name" value="zinc finger protein 827 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001733">
        <property type="entry name" value="zinc finger protein 827 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF62">
        <property type="entry name" value="ZINC FINGER PROTEIN 827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0779">Telomere</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="944"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="1028"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="1056"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="844"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO46365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1242" mass="138486" checksum="34EA404AD877CA93" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDB0</accession>
    <name>A0A151PDB0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RNA-binding protein 33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Proline-rich protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RNA-binding motif protein 33</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RBM33</name>
        <name evidence="21" type="ORF">Y1Q_0014505</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation. Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5. Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Associates with the NXF1-NXT1 RNA export complex. Interacts with ALKBH5; facilitating ALKBH5 recruitment to m6A-containing transcripts. Interacts with SENP1; promoting ALKBH5 deSUMOylation and subsequent activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDB0"/>
    <dbReference type="STRING" id="8496.A0A151PDB0"/>
    <dbReference type="eggNOG" id="ENOG502QR1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000245">
        <property type="entry name" value="RNA-binding protein 33 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039878">
        <property type="entry name" value="RBM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22014:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="1007"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="157"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="305"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="415"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="731"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="897"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO46939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1078" mass="121558" checksum="615B74C75697E25B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGH4</accession>
    <name>A0A151PGH4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myeloid-associated differentiation marker-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0016790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000348">
        <property type="protein sequence ID" value="KYO47885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGH4"/>
    <dbReference type="STRING" id="8496.A0A151PGH4"/>
    <dbReference type="eggNOG" id="KOG4788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047123">
        <property type="entry name" value="MYADM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068:SF3">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="151"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO47885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="314" mass="35161" checksum="713205F810FB6CC7" modified="2016-06-08" version="1">MPVQGSSSVGNTQALTCPMGIVRQLEALFTCVTFSLVASRGDSWAGTSKWCMFSWCFCFAVTLVVLLVESVGLQHRMPISWKNFHITFTMYAALFTLSASVIYPFTNIKDQQYCWEQDYHIAATFFSCLACIAYSVEVTMIHTTPGKVTGYMATMPGMLKVVETFIACIIFVFISNPIVYDRHEALKWCLAVYCFCFILSLVIFVLCVRECTGWLPCASNKILRGCTLLAVLLYSTATILWPLYNFDSRPRYCQGHNFCTRDKSLAITVLTVINLVVYLADLVYSVSSLFKPRCLHCLGERTGTGLWGLALATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGQ2</accession>
    <name>A0A151PGQ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0010589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000242">
        <property type="protein sequence ID" value="KYO48210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGQ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051896">
        <property type="entry name" value="TCR_alpha_variable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19339:SF5">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19339">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1279">T cell receptor</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007587025" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO48210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="110" mass="12367" checksum="23E5AB7BD9C39CDD" modified="2016-06-08" version="1">MRLPLALLCLVCTFCCCGAQVSQSPEALMTREGDRSTMTCTYSNTYRPFQWYRQVPSGEITHLLTVAANRNVTEGRVRGEWLESGQKSRLHIAGTRLDDSGRYFCAVEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGR6</accession>
    <name>A0A151PGR6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0010598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000242">
        <property type="protein sequence ID" value="KYO48219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGR6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051287">
        <property type="entry name" value="TCR_variable_region"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367:SF18">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="187"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO48219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="310" mass="34536" checksum="02756266AF80817A" modified="2016-06-08" version="1">MVIREGDRSAMVCTYSGAYRTFQWYRQAPSGVITHLLTVAADENVTEGRFTGERLESGKKSTLHVSETRLGDSGRYFCAEQHGAVRGDEIRPEEEQVSAAEGDAVTLRCFYTTTYSAGYNLYWYRQHRDRALQYILYKGTKENRRSSDIAEFAQQRFASQADDNSTVLIITALERADTASIESVLGPGVMDIGLTLAVWVLSTVGAVQGDLLHHAETDVSREEGASVTLLCFYNTSQDFISLLWYRQYPTRGPQYILGRGARSFSSVHYTAGFAQKRFSSQADRSTTVLNITALERPDTALYYSALSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PH42</accession>
    <name>A0A151PH42_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi-associated plant pathogenesis-related protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glioma pathogenesis-related protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GLIPR2</name>
        <name evidence="12" type="ORF">Y1Q_0022647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homodimer. Interacts with CAV1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000190">
        <property type="protein sequence ID" value="KYO48447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PH42"/>
    <dbReference type="STRING" id="8496.A0A151PH42"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000015">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="11">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO48447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="137" mass="14904" checksum="B825131E99D5CF9A" modified="2016-06-08" version="1">MGKSASKQFAEEVLKTHNDYRKKHGVPPLKICKALNSGAQQYAEALASTRVLKHSPESANGKCGENLAWASYDQPGKEVADRWYSEIKNYSFQNPGFSSGTGHFTAMIWKNTKKMGVGKATASDGSTFVVARGNKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PI95</accession>
    <name>A0A151PI95_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP-3 complex subunit sigma-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AP3S1</name>
        <name evidence="11" type="ORF">Y1Q_0004188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261592.1">
        <property type="nucleotide sequence ID" value="XM_006261530.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PI95"/>
    <dbReference type="STRING" id="8496.A0A151PI95"/>
    <dbReference type="GeneID" id="102562306"/>
    <dbReference type="KEGG" id="amj:102562306"/>
    <dbReference type="CTD" id="1176"/>
    <dbReference type="eggNOG" id="KOG0936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PI95"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO48831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="193" mass="21803" checksum="0E58EA39B4D55B3A" modified="2016-06-08" version="1">MIKAILIFNNHGKPRLSKFYQRYSEDIQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYA1</accession>
    <name>A0A151LYA1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007032">
        <property type="protein sequence ID" value="KYO17234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYA1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO17234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="89" mass="9982" checksum="5FA7FF9CB750C48E" modified="2016-06-08" version="1">MGENKWAALKTHHGERSYSVINGCWKERRKQLSFQGLKMFHSPGVSGEAEELDVASDKLFLLDILLSPPLEHNSLCNGDLRLYRIGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYU6</accession>
    <name>A0A151LYU6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYU6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO17421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="90" mass="9562" checksum="FB495367669B7EB3" modified="2016-06-08" version="1">MQVPSSCLSNGTVRIGYDQVTRLMACLHAQVSANFAATEVGGKKQNSALLNRSMFGAQEDTQAPVFWHSSALVDQSSSETSVMLLDLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1D2</accession>
    <name>A0A151M1D2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OR51L1</name>
        <name evidence="13" type="ORF">Y1Q_0012803</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006834">
        <property type="protein sequence ID" value="KYO18323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1D2"/>
    <dbReference type="GeneID" id="102563922"/>
    <dbReference type="KEGG" id="amj:102563922"/>
    <dbReference type="eggNOG" id="ENOG502SI1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6144443at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15222">
        <property type="entry name" value="7tmA_OR51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000002">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF37">
        <property type="entry name" value="OLFACTORY RECEPTOR 51L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO18323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="318" mass="35732" checksum="B5BBAD9682549D38" modified="2016-06-08" version="1">MSSFNISSIDLPTFFLTGFPGLEAAHHWISIIFCFIYLIAFLGNGIILVVIKMDPNLQGPMYVLLFMLATTDLGLSVSTLPTVLCLFWFNIREITFNACLSQLFFIHTFSFMESSVLLAMALDRYLAICNPLGYTRVLTNSVIAKLGLAMLVRSVGVVFPTPLLLRRYRYCRTNVLSHSFCLHQDVLKLACSDARVNSIYGLCVVLSTLAIDSVLILLSYIKIIKTILGIASKHERLKAFNTCASHICVVLIFFIPVIGVSMIHRFGKQASPILHILMANVYLLLPPVLNPLVYSVKTQQIRQGILRVFRKKRFNGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1G2</accession>
    <name>A0A151M1G2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1G2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="7762" checksum="29480FCE857640D8" modified="2016-06-08" version="1">MVARVPGTATHTHRNQAHWLGCYSCLVSLSLQVFSTASSLPRFAMPPVPTCACSVMELKISTMHLDLAEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M288</accession>
    <name>A0A151M288_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SNX9</name>
        <name evidence="13" type="ORF">Y1Q_0009101</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M288"/>
    <dbReference type="STRING" id="8496.A0A151M288"/>
    <dbReference type="eggNOG" id="KOG2528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M288"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07668">
        <property type="entry name" value="BAR_SNX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07285">
        <property type="entry name" value="PX_SNX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11898">
        <property type="entry name" value="SH3_SNX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000032">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000004">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037425">
        <property type="entry name" value="SNX9_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014536">
        <property type="entry name" value="Snx9_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037426">
        <property type="entry name" value="SNX9_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035558">
        <property type="entry name" value="SNX9_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF2">
        <property type="entry name" value="SORTING NEXIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027744">
        <property type="entry name" value="Snx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="255"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR027744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR027744-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO18637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="600" mass="67290" checksum="E2CBD32170BE2020" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3L3</accession>
    <name>A0A151M3L3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0017313</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006762">
        <property type="protein sequence ID" value="KYO19107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3L3"/>
    <dbReference type="eggNOG" id="ENOG502SKDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15912">
        <property type="entry name" value="7tmA_OR6C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000010">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047132">
        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF1">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="98"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO19107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="385" mass="44039" checksum="B07EFB64156D94EC" modified="2016-06-08" version="1">MTGFRMGYDTYIANDFKGRVTPSTNDSTAKLQIARLTLADTATYYCARETQHVAKEAMRSENQTMVKEFILLGFSGICEIKVLVFLTLFLTYMLTLMGNILIIALVWNDYRLHMPMYWFLCNLSFSGIWFTTVIIPKMMLNILLDTRTISFFGCLMQTYFYFFLGTSDYILVAVMSFDRYVAICNPLRYSVVMDGWFTFQLALGTWIGAFLSVLYPAIVFFQLPFCGPNVINHFFCDIIPVLKLACTDTILLEMLSFVSSSIVVLGSLLLTTVSYVYIITTILHIPSATGRQKAFSTCVSHITVASIFYGCSIFMYILPEKSHASWFYKVVAFLHTVVTPLLNPFIYTLRNKKVRDVLKDALKRAENSFPRDRVQGERESKKVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4W2</accession>
    <name>A0A151M4W2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 22">Dihydropyrimidine dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="22">DHPDHase</shortName>
            <shortName evidence="22">DPD</shortName>
            <ecNumber evidence="5 22">1.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 22">Dihydrothymine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 22">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">DPYD</name>
        <name evidence="24" type="ORF">Y1Q_0007492</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>5,6-dihydrothymine + NADP(+) = thymine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:27468"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:58286"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouracil + NADP(+) = uracil + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:18095"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 22">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="22">Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 22">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="5 22"/>
    <dbReference type="EMBL" id="AKHW03006584">
        <property type="protein sequence ID" value="KYO19562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006265324.1">
        <property type="nucleotide sequence ID" value="XM_006265262.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4W2"/>
    <dbReference type="STRING" id="8496.A0A151M4W2"/>
    <dbReference type="GeneID" id="102574438"/>
    <dbReference type="KEGG" id="amj:102574438"/>
    <dbReference type="CTD" id="1806"/>
    <dbReference type="eggNOG" id="KOG1799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000007">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000023">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000056">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000061">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14697">
        <property type="entry name" value="Fer4_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 22" id="KW-0274">FAD</keyword>
    <keyword evidence="8 22" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 22" id="KW-0288">FMN</keyword>
    <keyword evidence="16 22" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 22" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="23">
        <location>
            <begin position="944"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="23">
        <location>
            <begin position="978"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU364041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO19562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111523" checksum="0B7345A0990F3087" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M588</accession>
    <name>A0A151M588_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein RFX5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RFX5</name>
        <name evidence="7" type="ORF">Y1Q_0012342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RFX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006582">
        <property type="protein sequence ID" value="KYO19685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M588"/>
    <dbReference type="STRING" id="8496.A0A151M588"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000128">
        <property type="entry name" value="DNA-binding protein RFX5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF18">
        <property type="entry name" value="DNA-BINDING PROTEIN RFX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18326">
        <property type="entry name" value="RFX5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="133"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO19685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="200" mass="22598" checksum="52DA6599BF948D57" modified="2016-06-08" version="1">MTVVWMDILVMWTERKGALQEKSARFRYNLDLKSSKPHAMADNELSAKLSKKGSLPPGSSPGDATEPSILLQKLKSTISKMVQNKVDSILQDVQKFSDNDKLYLYLQLPSGPSSGEKSSLDLNSLNTAEHMHACNWIRNHLEEHTDTCLPKQDVYDAYKRYCDNLCCRPLSAANFGKIIREIFPHIKARRLGGRGQSKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5G4</accession>
    <name>A0A151M5G4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein FAM196B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006563">
        <property type="protein sequence ID" value="KYO19738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5G4"/>
    <dbReference type="STRING" id="8496.A0A151M5G4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029337">
        <property type="entry name" value="INSYN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28682">
        <property type="entry name" value="INHIBITORY SYNAPTIC FACTOR 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28682:SF6">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15265">
        <property type="entry name" value="FAM196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="8249" checksum="F1E32772B354891D" modified="2016-06-08" version="1">MGDLRSQLQSLEGVLETSQQTIKVLLDVIQDLEKKEAQRDGPSLGGYALRRSYRTGQDIANCGTCRDCACIIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M967</accession>
    <name>A0A151M967_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Multiple C2 and transmembrane domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MCTP1</name>
        <name evidence="15" type="ORF">Y1Q_0001351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Might play a role in the development of cardiac outflow tract.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M967"/>
    <dbReference type="STRING" id="8496.A0A151M967"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04042">
        <property type="entry name" value="C2A_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08376">
        <property type="entry name" value="C2B_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08377">
        <property type="entry name" value="C2C_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000019">
        <property type="entry name" value="Multiple C2 and transmembrane domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000076">
        <property type="entry name" value="multiple C2 and transmembrane domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000088">
        <property type="entry name" value="multiple C2 and transmembrane domain-containing protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013583">
        <property type="entry name" value="MCTP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF2">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08372">
        <property type="entry name" value="PRT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="818"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="292"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="456"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="602"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO21039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1003" mass="114057" checksum="35436871B55B206D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9I6</accession>
    <name>A0A151M9I6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BLOC1S6</name>
        <name evidence="2" type="ORF">Y1Q_0001445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9I6"/>
    <dbReference type="STRING" id="8496.A0A151M9I6"/>
    <dbReference type="eggNOG" id="ENOG502RZNC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328:SF2">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="199" mass="22292" checksum="93F1206954BD46EF" modified="2016-06-08" version="1">MSGAEPAAGEAGAALEPPGPRPLAPGSNDASPDEGLVEDLCLVDERAVEQLAEGLISHYLPDLQQSKQALQELTQNQAVLLDTLEQEISKFKECNSILDINTLFLEAKHYHSKLVNIRKEMLMLHEKTSKLKKRALKLQQKRQKEELEREQQLKSNHYDMERKYPNSATLSRAQPSNILLPGTSNSLMGLKINSWPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBT5</accession>
    <name>A0A151MBT5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBT5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="128" mass="13932" checksum="D73EDCA6A7AA0F3C" modified="2016-06-08" version="1">MRDLIAIWGEEEFQHQFLKGHHNRDIFKCIAQQIQSEAWPHVDILVHDVGGNLGDDIREGGPTHAEGLSPLFIVPGTQDNLLPPIAAGGMGPELVLDSLEVVPEHPAIHGILDVFVSHMKVGGPVQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC87</accession>
    <name>A0A151MC87_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tumor susceptibility 101 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TSG101</name>
        <name evidence="11" type="ORF">Y1Q_0000723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263545.1">
        <property type="nucleotide sequence ID" value="XM_006263483.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MC87"/>
    <dbReference type="STRING" id="8496.A0A151MC87"/>
    <dbReference type="GeneID" id="102558847"/>
    <dbReference type="CTD" id="7251"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MC87"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000040">
        <property type="entry name" value="tumor susceptibility gene 101 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF17">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="324"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO22121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="392" mass="44257" checksum="B3FD1FD985B14DC5" modified="2016-06-08" version="1">MALSESQLKKMLGKYKYRDLTVQETISVITQYKDLKPVMDAYVFNDGSSRELMSLSGTIPVPYRGNTYNIPICLWLLDTYPFNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLELIQVMIVVFGEEPPVFSRPTISASYPPYQPTGPPNASYMPGMPSGISPYPPGHPPNPSGYPSYPYPSGVPFPATTSAQHYPSQPPVTAVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLRKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMESQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCS5</accession>
    <name>A0A151MCS5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myeloid leukemia factor 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MLF2-1</name>
        <name evidence="6" type="ORF">Y1Q_0002905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MLF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCS5"/>
    <dbReference type="STRING" id="8496.A0A151MCS5"/>
    <dbReference type="eggNOG" id="KOG4049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8707547at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MCS5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019376">
        <property type="entry name" value="Myeloid_leukemia_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13105">
        <property type="entry name" value="MYELOID LEUKEMIA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10248">
        <property type="entry name" value="Mlf1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO22304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="243" mass="27642" checksum="7A7759D9199B4D85" modified="2016-06-08" version="1">MFRFMRDGEPEDPMFAMDPFAIHRQHMNRMLSGSFGFSPFLSITDGTMPGARQAGRRMQAVAISPFGMLGTAGGFMDMFGMMNDMIGNMEHMTSGANCQTFTSSTVISYSNLGDGPKVYQETSEMRSAPGGIRETRRTVRDSDSGLEQMSIGHHIGERAHIMQRSRNHRTGDQEERQDYINMDENDAAAFNDEWRRETSRYRPQRGLDYRRHEGSSGRRAEGTRLAIQGPEDSPSRQSRRYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MD34</accession>
    <name>A0A151MD34_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MD34"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="7877" checksum="5936C8A68C7631C0" modified="2016-06-08" version="1">MVQSPWSGPNFLSLVTRTNVQDLKVYCEVSASISSSVSIFASSIVRLSRSVFQYLSGHVQVLASYCSGPCSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MD65</accession>
    <name>A0A151MD65_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle and centriole-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Coiled-coil domain-containing protein 52</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SPICE1</name>
        <name evidence="13" type="ORF">Y1Q_0003029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331952.1">
        <property type="nucleotide sequence ID" value="XM_019476407.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MD65"/>
    <dbReference type="STRING" id="8496.A0A151MD65"/>
    <dbReference type="GeneID" id="102561048"/>
    <dbReference type="CTD" id="152185"/>
    <dbReference type="OrthoDB" id="6361178at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031387">
        <property type="entry name" value="SPICE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31167">
        <property type="entry name" value="SPINDLE AND CENTRIOLE ASSOCIATED PROTEIN 1 SPICE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31167:SF3">
        <property type="entry name" value="SPINDLE AND CENTRIOLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15678">
        <property type="entry name" value="SPICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="788"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="789"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO22458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="854" mass="94516" checksum="485B5344F3ACFCB0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDY9</accession>
    <name>A0A151MDY9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RWD domain-containing protein 2B isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RWDD2B-1</name>
        <name evidence="2" type="ORF">Y1Q_0003240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDY9"/>
    <dbReference type="STRING" id="8496.A0A151MDY9"/>
    <dbReference type="GeneID" id="102563115"/>
    <dbReference type="CTD" id="10069"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23829">
        <property type="entry name" value="RWD_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="29"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="308" mass="35220" checksum="B108D6A50F6A13AC" modified="2016-06-08" version="1">MRSSRKAGRGSSQNAAKMTNWEEAEVQISELDLLSSMFPGEDEFIVTDQLALAELKCCVENQSSEMPSSKVQFTLNVKLQVPDATMVEFSVFFALPLKYPTILPEITVRSPSLSRSQQIRLNTDLKNYLIRNCSGEPCVLSAREWVKDHALAYIDKETSSSSVVTSSSMETEDAIFTRLWIYSHHIYNKHKRKNIVDWAKELSLSGFCMPGKPGVVCVEGLQSTCEEFWARVRKLTWKRILIRHREDMSLEAGHAEIKKQRKFSSFEEKVFDAHGNRGNHMDLGQLYHFLDERGCADIFQMYFGVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFR6</accession>
    <name>A0A151MFR6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ADAMTS13</name>
        <name evidence="20" type="ORF">Y1Q_0005744</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MFR6"/>
    <dbReference type="GeneID" id="102565959"/>
    <dbReference type="KEGG" id="amj:102565959"/>
    <dbReference type="CTD" id="11093"/>
    <dbReference type="OrthoDB" id="9942326at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000003">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF20">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585143" evidence="18">
        <location>
            <begin position="19"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="19">
        <location>
            <begin position="206"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="14 17">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="281"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="328"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="517"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO23358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1597" mass="174899" checksum="B463F8AD02A08959" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MG94</accession>
    <name>A0A151MG94_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 100-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0010096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006198">
        <property type="protein sequence ID" value="KYO23529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MG94"/>
    <dbReference type="STRING" id="8496.A0A151MG94"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071773">
        <property type="term" value="P:cellular response to BMP stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032536">
        <property type="entry name" value="TMEM100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16100">
        <property type="entry name" value="PHOSPHOINOSITIDE-INTERACTING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16100:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16311">
        <property type="entry name" value="TMEM100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO23529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="164" mass="17866" checksum="6A302604FB2D8E0D" modified="2016-06-08" version="1">MEGNQAERRRKEQDQDPGRKEQFRSASEPREETTGPSPVMSNPPRPYNSVRLHVGSEEVHFERSAPDPHLVSTATGGVEDSCPRCLLPFGLVITLMGLAVTGVAYAHDTHGSVLSVLGLALLGTGVLGIAGSCIMKRCWCRHLLGWHRGSITLLMDEQLQKAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHQ7</accession>
    <name>A0A151MHQ7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO24055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHQ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO24055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="13831" checksum="FB0630C610450844" modified="2016-06-08" version="1">MLERATGERGGAGDNWSEEEADAAGKKGTRVRSGEKKSDEKGLTESEEDQRDVLEVETPVRDREGSLLVLPSDEEVRVDPEDYQVPAITKEGTVTAPDSRAQVELPVFFIFNLDAMVDAGVVPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHW3</accession>
    <name>A0A151MHW3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO24073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHW3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="161" mass="18144" checksum="1ED54DAC502F24D6" modified="2016-06-08" version="1">MLEKTTCASAQNGSEIFGFLSRGISFQVKKKSHNDSPMALVSHNPFCSTLPCGHAPGCRDHPVPHCPQAFNYQPLGCLLDSSKDANDADMNITMIAVYKFLGLQPCHFWASSASQDYWHHVVQLIWSDNQWLNSFQELLYQLRQHLGQQPTTMRPPVPKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIV7</accession>
    <name>A0A151MIV7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PITX2-1</name>
        <name evidence="15" type="ORF">Y1Q_0002043</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006071">
        <property type="protein sequence ID" value="KYO24409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIV7"/>
    <dbReference type="STRING" id="8496.A0A151MIV7"/>
    <dbReference type="GeneID" id="102577301"/>
    <dbReference type="KEGG" id="amj:102577301"/>
    <dbReference type="CTD" id="5308"/>
    <dbReference type="eggNOG" id="KOG0486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MIV7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000031">
        <property type="entry name" value="Homeobox protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016233">
        <property type="entry name" value="Homeobox_Pitx/unc30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF4">
        <property type="entry name" value="PITUITARY HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000563">
        <property type="entry name" value="Homeobox_protein_Pitx/Unc30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="83"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="14">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO24409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="317" mass="35338" checksum="E6A12B998BC987FA" modified="2016-06-08" version="1">MESNCRKLVSACVQLGVQPAAVECLFSKDTDLKKGDFSDSADSRKEATSSKLFGRQHPSAHEKEKSQQSKNEDPGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDEMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSNPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK25</accession>
    <name>A0A151MK25_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Laminin subunit alpha-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LAMA4</name>
        <name evidence="17" type="ORF">Y1Q_0017826</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006032">
        <property type="protein sequence ID" value="KYO24740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MK25"/>
    <dbReference type="eggNOG" id="KOG1836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000051">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000569">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000053">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000058">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000064">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000066">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000087">
        <property type="entry name" value="Laminin subunit alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009254">
        <property type="entry name" value="Laminin_aI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010307">
        <property type="entry name" value="Laminin_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF47">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06008">
        <property type="entry name" value="Laminin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06009">
        <property type="entry name" value="Laminin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="132"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="187"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="835"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="1048"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="1235"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="1472"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="15">
        <location>
            <begin position="1649"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1414"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="339"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="565"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1414"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO24740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1825" mass="203486" checksum="FBD0638A806AE351" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMN1</accession>
    <name>A0A151MMN1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Interleukin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0001844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the IL-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005679">
        <property type="protein sequence ID" value="KYO25689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMN1"/>
    <dbReference type="STRING" id="8496.A0A151MMN1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005149">
        <property type="term" value="F:interleukin-1 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001660">
        <property type="term" value="P:fever generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000975">
        <property type="entry name" value="IL-1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10078:SF30">
        <property type="entry name" value="INTERLEUKIN-1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10078">
        <property type="entry name" value="INTERLEUKIN-1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00340">
        <property type="entry name" value="IL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00264">
        <property type="entry name" value="INTERLEUKIN1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01359">
        <property type="entry name" value="INTRLEUKIN1B"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01357">
        <property type="entry name" value="INTRLEUKN1AB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00125">
        <property type="entry name" value="IL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0497">Mitogen</keyword>
    <keyword evidence="8" id="KW-0666">Pyrogen</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO25689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="129" mass="14556" checksum="10520D332DC6BDC8" modified="2016-06-08" version="1">MRPLMACQNSSSSTCINIYRLQSAAQSQFLVRLPVALGIKDKGLYLSSVLSGDQPMLQLAEAEVKRDISGDDFQYFIYCIQVDNMTKFEFTSHPSWYICTSQEPSQPVGITNCLGKDLITDYHLTRPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN23</accession>
    <name>A0A151MN23_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Stathmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">STMN2</name>
        <name evidence="12" type="ORF">Y1Q_0003722</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the stathmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276030.1">
        <property type="nucleotide sequence ID" value="XM_006275968.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN23"/>
    <dbReference type="STRING" id="8496.A0A151MN23"/>
    <dbReference type="GeneID" id="102574942"/>
    <dbReference type="KEGG" id="amj:102574942"/>
    <dbReference type="CTD" id="11075"/>
    <dbReference type="eggNOG" id="ENOG502RENQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5986631at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MN23"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030514">
        <property type="entry name" value="Stathmin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF18">
        <property type="entry name" value="STATHMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002285">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01041">
        <property type="entry name" value="STATHMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO25935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="179" mass="20907" checksum="5457285AE6037C00" modified="2016-06-08" version="1">MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYKYDDMEVKQINKRASGQAFELILKPPSPVSEAPRTLASPKKKELSREEIQKKLEAAEERRKSQEAQVLKHLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAALIERLQEKERHAAEVRRNKELQVELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MND2</accession>
    <name>A0A151MND2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MND2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="7788" checksum="C118FBFAC251A63A" modified="2016-06-08" version="1">MGGEDALGEVPACSSLSISTINTCSSTIHGKPGSLLINYQHQARSSLLRGGSGIGICVCFQHWFGVLSAPDRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQC3</accession>
    <name>A0A151MQC3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQC3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="110" mass="12620" checksum="4726B6D92DF96902" modified="2016-06-08" version="1">MCSCLLLLGNYKLIGNGIKKSYLCKQFQIVQDPFTEGRKKMSSYALPARRSLLMEDVMIILWHPADLKPTNAFKLAFPKVDIPDWQSRLRSILLRKMTVHDIASHSDSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRX0</accession>
    <name>A0A151MRX0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005250">
        <property type="protein sequence ID" value="KYO27223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRX0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7898" checksum="90972CF1E8B24FF6" modified="2016-06-08" version="1">MWRLTWYWERLSPIFTPLQQAIMVCKPAFKSDGFQRQQGSKTLQQQTKAYSAASAENNRQKELRATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MS61</accession>
    <name>A0A151MS61_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ORC6</name>
        <name evidence="14" type="ORF">Y1Q_0021199</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005226">
        <property type="protein sequence ID" value="KYO27259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006272329.1">
        <property type="nucleotide sequence ID" value="XM_006272267.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MS61"/>
    <dbReference type="STRING" id="8496.A0A151MS61"/>
    <dbReference type="GeneID" id="102568030"/>
    <dbReference type="KEGG" id="amj:102568030"/>
    <dbReference type="CTD" id="23594"/>
    <dbReference type="eggNOG" id="KOG4557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5552484at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MS61"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16075">
        <property type="entry name" value="ORC6_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11583">
        <property type="entry name" value="Orc6_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000054">
        <property type="entry name" value="origin recognition complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054113">
        <property type="entry name" value="ORC6_cyclin-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020529">
        <property type="entry name" value="ORC6_met/pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21913">
        <property type="entry name" value="ORC6_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="12">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ORC6 second cyclin-like" evidence="13">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO27259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="267" mass="29533" checksum="6F1F1BA9D9744B0A" modified="2016-06-08" version="1">MEQGLIRRLAPRLGITEPAIIRKAEEHLRLSQVKCTGLLTQMTATSHAVMCLDLAASFMKQPVDKSYFVRLSGLNKTTYQNCVKSFECLLGMNSSLGIRDLAVQFCCTEAINTAAKLLQRYESSLSEAQQMALDLSKPLFTTAALFTACRCLKLKVDKKKLVATSGVKKALFDRLCSQLEKLSQQISKDCNPLTPSPTKSPETLLQCIEKEQEAEDELDTPCKRQKCETDPKQDYEEWKKRILESATKAQKTSGPGGSPNSITATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTK6</accession>
    <name>A0A151MTK6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PRP39 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0006899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRP39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005076">
        <property type="protein sequence ID" value="KYO27846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTK6"/>
    <dbReference type="STRING" id="8496.A0A151MTK6"/>
    <dbReference type="eggNOG" id="KOG1258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000063">
        <property type="entry name" value="Pre-mRNA processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000091">
        <property type="entry name" value="Pre-mRNA-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF24">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="363"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO27846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="614" mass="71427" checksum="FF69DEED3B5F53F9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU78</accession>
    <name>A0A151MU78_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO28048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MU78"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="11134" checksum="2BC38F404B8D867A" modified="2016-06-08" version="1">MPTEHHGSFATVGLRNWATRVMYVCNYIHLRRPRTAERAVPGAALPLGLVLPENMNIRAIDFNRFRKNLKKRYPEDTGWSFLALWKQVSCTLRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVL6</accession>
    <name>A0A151MVL6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosinase</fullName>
            <ecNumber evidence="4">1.14.18.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Monophenol monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TYR</name>
        <name evidence="21" type="ORF">Y1Q_0005334</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Melanosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03004889">
        <property type="protein sequence ID" value="KYO28535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276940.1">
        <property type="nucleotide sequence ID" value="XM_006276878.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVL6"/>
    <dbReference type="STRING" id="8496.A0A151MVL6"/>
    <dbReference type="GeneID" id="102560883"/>
    <dbReference type="KEGG" id="amj:102560883"/>
    <dbReference type="CTD" id="7299"/>
    <dbReference type="eggNOG" id="ENOG502QRET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043473">
        <property type="term" value="P:pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1280.10:FF:000003">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF124">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585495" description="Tyrosinase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="19">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="20">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO28535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="528" mass="60136" checksum="6E5A434E86680BC0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVP7</accession>
    <name>A0A151MVP7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WW domain-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">WBP1</name>
        <name evidence="5" type="ORF">Y1Q_0009449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004861">
        <property type="protein sequence ID" value="KYO28600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVP7"/>
    <dbReference type="STRING" id="8496.A0A151MVP7"/>
    <dbReference type="eggNOG" id="ENOG502RYC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021684">
        <property type="entry name" value="WBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051994">
        <property type="entry name" value="WW_domain-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209:SF5">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11669">
        <property type="entry name" value="WBP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="4">
        <location>
            <begin position="193"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO28600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="549" mass="60653" checksum="02AF2C499C956A83" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWM4</accession>
    <name>A0A151MWM4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="12">MAD homolog</shortName>
            <shortName evidence="12">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0009747</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWM4"/>
    <dbReference type="STRING" id="8496.A0A151MWM4"/>
    <dbReference type="eggNOG" id="KOG3701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10498">
        <property type="entry name" value="MH2_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF63">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="15">
        <location>
            <begin position="288"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO28904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="517" mass="56476" checksum="A581D78D7317E0E1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX70</accession>
    <name>A0A151MX70_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX70"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="11237" checksum="A36144C9CB21F9CA" modified="2016-06-08" version="1">MKSSRGFLTHIHLFGLRYEGQYTRENKVDLRCYVWLALGVWLELAQDGACAFASEDNSRNRETEEFWHGKWDVAYQPLTVASTQTQTERRKNSYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MY33</accession>
    <name>A0A151MY33_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004688">
        <property type="protein sequence ID" value="KYO29461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MY33"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="123" mass="13734" checksum="7D4D81048F344686" modified="2016-06-08" version="1">MHELERVQENRAFRVRLLALEERHFTLLEKVLEAQEQQAAMVARAVEAIEEDCQVLDTILSLGVSFVLPTTQSLVLALPAPWQSLAMNTWADVQQCPFDQSPLSRHACAPEVVQSESGVLDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1J0</accession>
    <name>A0A151N1J0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1J0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="99" mass="10982" checksum="AE0A0CEEFEC6AAA2" modified="2016-06-08" version="1">MEVIDLKLPSRGFSTSDASAGRCLMDQAQGSLGPGFGQADVEPDITVSLLLEKLQQEEETRETIYSSLEKDLQGDTKSLDRSLVRRIIHLASKDMRETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N253</accession>
    <name>A0A151N253_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0007708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004139">
        <property type="protein sequence ID" value="KYO30881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N253"/>
    <dbReference type="STRING" id="8496.A0A151N253"/>
    <dbReference type="eggNOG" id="ENOG502RB0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF73">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="492"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO30881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="742" mass="80669" checksum="5182E853E5076EE8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3S9</accession>
    <name>A0A151N3S9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004108">
        <property type="protein sequence ID" value="KYO31285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3S9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="8127" checksum="B2CDBFCBE70E0696" modified="2016-06-08" version="1">MEKGALRLLNDLDFLRKYWVLKGTSAKLKWSLALQDYNMRGIRIKNNKNLITDALPWKTGNTRSWMKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4N1</accession>
    <name>A0A151N4N1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="13">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0022854</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the Deltex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4N1"/>
    <dbReference type="STRING" id="8496.A0A151N4N1"/>
    <dbReference type="KEGG" id="amj:106737199"/>
    <dbReference type="eggNOG" id="ENOG502QQ9M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2449614at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16671">
        <property type="entry name" value="RING-H2_DTX1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000097">
        <property type="entry name" value="E3 ubiquitin-protein ligase DTX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000004">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000005">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.130:FF:000001">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WWE" evidence="16">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="16">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="411"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO31783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="620" mass="68449" checksum="C867DA87655896CC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N529</accession>
    <name>A0A151N529_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">COX6A1</name>
        <name evidence="14" type="ORF">Y1Q_0022793</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N529"/>
    <dbReference type="STRING" id="8496.A0A151N529"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00925">
        <property type="entry name" value="Cyt_c_Oxidase_VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO31699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="11125" checksum="D5CBDBCED8D205A6" modified="2016-06-08" version="1">MRNVWKARGLEYSERGPTVQARTWKLLTFFVALPGVAVCMLNCYLKAQHKHERPEFIPYPHLRIRTKPFPWGDGNKSLFHNPHVNPLPTGYEDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5V8</accession>
    <name>A0A151N5V8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5V8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7494" checksum="40BE57427F2B7C36" modified="2016-06-08" version="1">MMPPRTKLLGTPIWSETGSTDKHREESEAGLTPAETAAAVHAWQPRRLREKKASCQHALTIKETAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5X8</accession>
    <name>A0A151N5X8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-2-macroglobulin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004002">
        <property type="protein sequence ID" value="KYO32253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5X8"/>
    <dbReference type="STRING" id="8496.A0A151N5X8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF182">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-macroglobulin-like TED" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin-like TED" evidence="1">
        <location>
            <begin position="130"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="187" mass="20805" checksum="8FF08AC9A1375C8B" modified="2016-06-08" version="1">MPGYQCELTYKHDDGSYSALGKSDATDNTWLTAFVVKCFGQARPYIFIDQQHIEDALKWLQQHQMESGCFQSVGKLLNNALQGSSWLEGAVSQQDSALSLSPFYTVSENISLAIPGNIVAGSERAHVTVLGNTWLTAFVVKCFGQARPYIFIDQQHIEDALKWLQQHQMESGCFQSVGKLLNNALQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5X9</accession>
    <name>A0A151N5X9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable ATP-dependent RNA helicase DHX40</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DEAH box protein 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DHX40</name>
        <name evidence="14" type="ORF">Y1Q_0007209</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable ATP-dependent RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5X9"/>
    <dbReference type="STRING" id="8496.A0A151N5X9"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17984">
        <property type="entry name" value="DEXHc_DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000009">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001082">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF271">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX40-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="90"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="291"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="754"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO32236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="806" mass="90380" checksum="ABB678DF76ADBEEF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N715</accession>
    <name>A0A151N715_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCAAT/enhancer-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CEBPA</name>
        <name evidence="11" type="ORF">Y1Q_0007795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bZIP family. C/EBP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003905">
        <property type="protein sequence ID" value="KYO32610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274363.1">
        <property type="nucleotide sequence ID" value="XM_006274301.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N715"/>
    <dbReference type="STRING" id="8496.A0A151N715"/>
    <dbReference type="GeneID" id="102575011"/>
    <dbReference type="KEGG" id="amj:102575011"/>
    <dbReference type="CTD" id="1050"/>
    <dbReference type="eggNOG" id="KOG3119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10032067at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030099">
        <property type="term" value="P:myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14711">
        <property type="entry name" value="bZIP_CEBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000028">
        <property type="entry name" value="CCAAT/enhancer-binding protein beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031106">
        <property type="entry name" value="C/EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016468">
        <property type="entry name" value="C/EBP_chordates"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334">
        <property type="entry name" value="CCAAT/ENHANCER BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23334:SF5">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005879">
        <property type="entry name" value="CCAAT/enhancer-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="241"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO32610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="317" mass="35018" checksum="09E9A4CF377DCF65" modified="2016-06-08" version="1">MEQANFYEVESRPPPSSVQPPHLPPPPPGSAYGAYREAPPAPELSDICEHENSIDISAYIDPAAFNDEFLADLFQHSRQQDKAKAALAADFDFHGLHGPGAPGQGPPPQPPPPPPQPLFGYLDGKLDALYERIAAPGLRPLLIKQEPREDEEAKPAALPALYPAQPPAPSHLQYQIAHCAQTTMHLQPGHPTPPPTPVPSPHHAHPHPHPHPHAHPHPPAALKMLPAEPRGKTKKTVDKSSSEYRVRRERNNIAVRKSRDKAKQRNAETQQKVLELTTDNDRLRKRVEQLSRELETLRGIFRQLPESSLVKAMGNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7N0</accession>
    <name>A0A151N7N0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7N0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7665" checksum="3A8943C42DDD8AB0" modified="2016-06-08" version="1">MRGGDSDPILATMGKLGERRRQKKYGECIETTTERHQPEDSEENPAANVGDEVATMFQLVFQIPVANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAD5</accession>
    <name>A0A151NAD5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Germinal-center associated nuclear protein</fullName>
            <ecNumber evidence="5">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">MCM3AP</name>
        <name evidence="28" type="ORF">Y1Q_0008738</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the SAC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NAD5"/>
    <dbReference type="eggNOG" id="KOG1860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000003">
        <property type="entry name" value="germinal-center associated nuclear protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031910">
        <property type="entry name" value="GANP_CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031907">
        <property type="entry name" value="MCM3AP_GANP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16766">
        <property type="entry name" value="CID_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16769">
        <property type="entry name" value="MCM3AP_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="20" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17 25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="18" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PCI" evidence="27">
        <location>
            <begin position="481"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1516"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="845"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00055631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00069544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KYO33569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1693" mass="191041" checksum="F25C68C9793C9F26" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAQ8</accession>
    <name>A0A151NAQ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAQ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="99" mass="11041" checksum="6DDA81B24471A3F1" modified="2016-06-08" version="1">MTWATFQDLMEQLCPHLEWQDTNVWQTFPLGTQLVIALVKLATPTSLHNVGHLFSMGKVTAKKAVLQATSCTHHLSYRAMSSTHDIYESSCQSSMAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NB70</accession>
    <name>A0A151NB70_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO34052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NB70"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8826" checksum="9A015F657D244089" modified="2016-06-08" version="1">MDYTSLMVELILKREKDGNQEQLANSKITLKQPFLCFITLTGTLHTEDQDSLQTMYRMKKEFSYDNAMIKQDAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NC46</accession>
    <name>A0A151NC46_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RasGAP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003525">
        <property type="protein sequence ID" value="KYO34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NC46"/>
    <dbReference type="STRING" id="8496.A0A151NC46"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF15">
        <property type="entry name" value="RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RasGAP protein C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="8995" checksum="40F4490A65871977" modified="2016-06-08" version="1">MKGKNSKKISLKYTAARLHEKGVLLEIEDLQANQFKNVIFEINPTEEVGDFEVKAKFMGVQMETFMLHYQDFLVGNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NC83</accession>
    <name>A0A151NC83_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-defensin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0012998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003504">
        <property type="protein sequence ID" value="KYO34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NC83"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001855">
        <property type="entry name" value="Defensin_beta-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00711">
        <property type="entry name" value="Defensin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57392">
        <property type="entry name" value="Defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-defensin-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8105" checksum="F65EEA97B475F0EB" modified="2016-06-08" version="1">MPNPVGEKQPHKEADTWDGVEDDASKAKGNVEAEGAGGENNPMVCSYSGGSCRQRCIGHEVMVGKCYGTFICCVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCB6</accession>
    <name>A0A151NCB6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Acidic mammalian chitinase</fullName>
            <ecNumber evidence="7">3.2.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Chitinase-3-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">Y1Q_0023692</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="25">Interacts with EGFR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03003562">
        <property type="protein sequence ID" value="KYO34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCB6"/>
    <dbReference type="STRING" id="8496.A0A151NCB6"/>
    <dbReference type="KEGG" id="amj:102559369"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NCB6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000001">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000081">
        <property type="entry name" value="Chitinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF202">
        <property type="entry name" value="CHITINASE-3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="13" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="22" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="18" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="12" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="23" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0391">Immunity</keyword>
    <keyword evidence="21" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="24" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="14 27" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585934" description="Acidic mammalian chitinase" evidence="27">
        <location>
            <begin position="22"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="29">
        <location>
            <begin position="22"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="28">
        <location>
            <begin position="434"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00062006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00072739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KYO34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="483" mass="53499" checksum="5B8BB70160F6519F" modified="2016-06-08" version="1">MGQAIIWAGLAVLLLLQCGSACKLVCYFTNWSQYRPAQGRFFPENIDTNLCTHLIYAFAGMNENRITTIEWNDEQFYKTFNGLKSKNPSLKTLLSIGGWNFGSQKFSTMVSTPATRWTFILSVLQFLRQYGFDGLDIDWEYPAARGSPPEDKQRFTALVQEMAKEFTEEGKRTQKERLLLTAAVAAGREKINAGYEVSDILKELDFINLMTYDFHGSWEHTTGHVSPLYKGNNETGPAEYSNTDAAVKYWISKGAPAEKIIMGIPTYGRGFTLSSSDSDVGAPTSGPSTAGTFTREAGFLAYYEICTFLKGATTKRIKDQKVPYSFKDKEWVGYDDMESITTKVQYLKNNSLGGAMIWALDLDDFSGSFCNQGAYPLLNTLKKLGCGMAQPTAASTTARMAQSTAASTTARMARSTAASTSTNLKTTPRPVPASKFCLNKDDGIYPVPEDNTKFYICANRATFRMSCPDGLVYNGTCKCCNWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDI7</accession>
    <name>A0A151NDI7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 120 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CCDC120</name>
        <name evidence="6" type="ORF">Y1Q_0017063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003281">
        <property type="protein sequence ID" value="KYO34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019346485.1">
        <property type="nucleotide sequence ID" value="XM_019490940.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059589063.1">
        <property type="nucleotide sequence ID" value="XM_059733080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDI7"/>
    <dbReference type="STRING" id="8496.A0A151NDI7"/>
    <dbReference type="GeneID" id="109283990"/>
    <dbReference type="KEGG" id="amj:109283990"/>
    <dbReference type="CTD" id="90060"/>
    <dbReference type="OrthoDB" id="9428637at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NDI7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043447">
        <property type="entry name" value="CCDC120/INAVA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16093:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16093">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 120 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytohesin Ubiquitin Protein Inducing" evidence="5">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="437" mass="47628" checksum="7BE92FE36F85F526" modified="2016-06-08" version="1">MEVKGQLITSAEPPGRDPGTRLRELLERQRGLEETLALRVRELRRLCWLEAELTGHLPPEYPLEPGERPQPVRRRVIPNPWGPQTEAGQRALGRQVQLQRQVLEAARRLVLAPGLSVEQRCRRQRVQAEAAQRLRQLEAQLGAYDEAFYPNSSPLVELVNQENGTPPGIPADPSPPRSRDHLRATSNSPDRCPVAWRGLGPDPLGTRRNSLASPPSPTRPLPRSASSFEGRSVPATPILSRGSYNHNQHLRPDPPRLWQGPVDSPTPGARRSNSSEALIERGGGLGDPSPPAQRPPPYAHLLLDYYLERQGRGGGGSSGSPPHQTRRAGRAKSCGPPQSHPPWGGGPPAPPRGGQKALALEGLREWYLRHAGPPLPPNRRGGPPTPRWPDPSLLPHSLSYAGPPPQGRPFADFLCPDSPPGPTPPRDPDTQPPGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDT2</accession>
    <name>A0A151NDT2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0000887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDT2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585980" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14137" checksum="422551CA395E988A" modified="2016-06-08" version="1">MSVGGWWNWSPCVVAATLVSSRRCGFQAVAGGGWSGAAGCPVSAGTRSQTPAEERQGNRSEGGFCSVISHRGVSRGPGLTLSPFLPAAVIPRPATEEDEDEDEEEEDEDGRPPEAAALLFVTKHLKEPGKSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDW6</accession>
    <name>A0A151NDW6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase 21 kDa proteolipid subunit c''</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Vacuolar proton pump 21 kDa proteolipid subunit c''</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ATP6V0B</name>
        <name evidence="15" type="ORF">Y1Q_0019025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with IFITM3. Interacts with TM4SF19; this interaction inhibits V1-V0 complex assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
            <location evidence="8">Clathrin-coated vesicle membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003309">
        <property type="protein sequence ID" value="KYO34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019346516.1">
        <property type="nucleotide sequence ID" value="XM_019490971.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDW6"/>
    <dbReference type="STRING" id="8496.A0A151NDW6"/>
    <dbReference type="GeneID" id="102557934"/>
    <dbReference type="KEGG" id="amj:102557934"/>
    <dbReference type="CTD" id="533"/>
    <dbReference type="eggNOG" id="KOG0233">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="14">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="14">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="205" mass="20957" checksum="E5CD353315905FC9" modified="2016-06-08" version="1">MTGLPLLGAGVALAAAVTLLGVGVCYTIFDLGFRFDVAWFLTETSPFMWACLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAESFTGTTPESIGARNYHAGFSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNASLFVKILIVEIFGSAIGLFGVIVSILQTSKVKMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFP5</accession>
    <name>A0A151NFP5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-related GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RRAGD</name>
        <name evidence="13" type="ORF">Y1Q_0013832</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003146">
        <property type="protein sequence ID" value="KYO35623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFP5"/>
    <dbReference type="STRING" id="8496.A0A151NFP5"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000001">
        <property type="entry name" value="Ras-related GTP-binding protein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000226">
        <property type="entry name" value="Ras-related GTP-binding protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF6">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO35623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="333" mass="37985" checksum="0A89D483325DD00A" modified="2016-06-08" version="1">MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVASHRTCNHQASTPNMKAVTHNGTPRNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG51</accession>
    <name>A0A151NG51_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein C-ets-1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ETS1</name>
        <name evidence="12" type="ORF">Y1Q_0010193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG51"/>
    <dbReference type="STRING" id="8496.A0A151NG51"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08542">
        <property type="entry name" value="SAM_PNT-ETS-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000097">
        <property type="entry name" value="Protein c-ets-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000014">
        <property type="entry name" value="Protein c-ets-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045688">
        <property type="entry name" value="Ets1_N_flank"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041886">
        <property type="entry name" value="SAM_PNT-ETS-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016311">
        <property type="entry name" value="Transform_prot_C-ets"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF209">
        <property type="entry name" value="ETS TRANSLOCATION VARIANT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19525">
        <property type="entry name" value="Ets1_N_flank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001698">
        <property type="entry name" value="Transforming_factor_C-ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PNT" evidence="11">
        <location>
            <begin position="150"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="10">
        <location>
            <begin position="434"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO35768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="540" mass="61833" checksum="D3D257B4737D0634" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NH23</accession>
    <name>A0A151NH23_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">OR6Q1</name>
        <name evidence="15" type="ORF">Y1Q_0013155</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NH23"/>
    <dbReference type="GeneID" id="102560177"/>
    <dbReference type="KEGG" id="amj:102560177"/>
    <dbReference type="eggNOG" id="ENOG502QVH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9444602at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13954">
        <property type="entry name" value="7tmA_OR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050516">
        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO36121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="314" mass="35642" checksum="9D91CAB243B3C8EA" modified="2016-06-08" version="1">MGASNWTLVTEFIILGFPYARETELILFAVFLLMYALTFTENIVIILVIGMDYRLHTPMYFFISNLSVLEIGYTTVTVPKMLANIAIQSRTISITGCFTQLYIFFFLGSAECFLLAAMAYDRYLAICNPLHYTTMMDRRVCVRLALGSWLGGFLAPAVPTAFIFRLPFCGSNVINHFFCDSPPLLELSCRDIFEIEVINFMVGTAVLLSSFVLTMVSYIFIVATILRIPTAEGRSKAFSTCASHLTIVTMFYGTTIFMYIRTKTIQAFDFNKVVSIFYSVLTPVINPIIYSLRNNDIKQAMRKVLLRKKDFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIV2</accession>
    <name>A0A151NIV2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WASH complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0024179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIV2"/>
    <dbReference type="STRING" id="8496.A0A151NIV2"/>
    <dbReference type="KEGG" id="amj:102573754"/>
    <dbReference type="eggNOG" id="KOG3578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261210at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NIV2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028191">
        <property type="entry name" value="WASH-4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028283">
        <property type="entry name" value="WASH-7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028282">
        <property type="entry name" value="WASH-7_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027307">
        <property type="entry name" value="WASH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14745">
        <property type="entry name" value="WASH-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14746">
        <property type="entry name" value="WASH-7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14744">
        <property type="entry name" value="WASH-7_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH complex subunit 4 N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 central" evidence="2">
        <location>
            <begin position="605"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 C-terminal" evidence="4">
        <location>
            <begin position="966"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO36435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1173" mass="136008" checksum="A40C12EC42418484" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJ95</accession>
    <name>A0A151NJ95_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Neuronal growth regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NEGR1</name>
        <name evidence="15" type="ORF">Y1Q_0020888</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the immunoglobulin superfamily. IgLON family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJ95"/>
    <dbReference type="STRING" id="8496.A0A151NJ95"/>
    <dbReference type="eggNOG" id="KOG3510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000305">
        <property type="entry name" value="neurotrimin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000113">
        <property type="entry name" value="Opioid-binding protein/cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050876">
        <property type="entry name" value="IgLON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42757">
        <property type="entry name" value="IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42757:SF6">
        <property type="entry name" value="NEURONAL GROWTH REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="97"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO36861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="225" mass="24566" checksum="5B9F26CB195FE3F1" modified="2016-06-08" version="1">MQVHLIVQVSPKIYHISTDIVVNEGSNVTLACLATGKPEPSISWRHISPSAKPFESGQYLDIYGITRDQTGDYECSAENDVSVPDVRKVKVTVNFAPTIQELKSSGVMLGGNGLIRCEGAGVPTPVFEWYKGERKLINGQQGITIKNYNTRSLLSVTNVTEEHFGNYTCVAANKLGLTNASLPLNPPSTAQYGITGGAEVLFSCWYLLTLSSFTSIFYLKNIILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK10</accession>
    <name>A0A151NK10_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dickkopf-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DKKL1</name>
        <name evidence="11" type="ORF">Y1Q_0008417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dickkopf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059584152.1">
        <property type="nucleotide sequence ID" value="XM_059728169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK10"/>
    <dbReference type="STRING" id="8496.A0A151NK10"/>
    <dbReference type="GeneID" id="102576488"/>
    <dbReference type="CTD" id="27120"/>
    <dbReference type="eggNOG" id="KOG1218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039706">
        <property type="term" value="F:co-receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006796">
        <property type="entry name" value="Dickkopf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039863">
        <property type="entry name" value="DKK1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113:SF8">
        <property type="entry name" value="DICKKOPF-RELATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113">
        <property type="entry name" value="DICKKOPF3-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04706">
        <property type="entry name" value="Dickkopf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586123" evidence="9">
        <location>
            <begin position="25"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Dickkopf N-terminal cysteine-rich" evidence="10">
        <location>
            <begin position="128"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO37141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="368" mass="40902" checksum="A618E1B41FB510F2" modified="2016-06-08" version="1">MAARGLPGALGALLLLLLAWEGAGAPAFLPPAALQRLLGDLSSMMQRSREEMGQMEEGFETPVDFSKLPPNYHDEEKEERRVGNATVYSHREINKVTDNRTGETVFSEKTVTSIEQGDRGLLENWKGCMGDDDCRKDQFCSSSFVVSQCQECKAKDTVCQRDGECCLGYLCVWGKCTAGVSRGEGGTRCDPLQDECAPGLCCISYAFFPFPICAPYLTEGEVCQSLDGTLLSLMAWEGLGRSGQYCPCAQELMCRSNGFGMTSTCQRAEGNEDFGRLGQQLSFFQPSMVRRDEEVAYYDTNALPWQLQDGQMVVDTGRIKKPREELTDDYEGENLLLDKDTNNPDQLNFQELKQLANQMGQYFGPGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLQ4</accession>
    <name>A0A151NLQ4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLQ4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9536" checksum="132677CF9CA031FF" modified="2016-06-08" version="1">MGSQGSEITFPCPELSQKEAIVGADQEDRILSVQWDHLEIEKTDNAIPVLEGNGIHAALLFMPKLEDKTTVALLMKGSLLFGTKLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMP1</accession>
    <name>A0A151NMP1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002540">
        <property type="protein sequence ID" value="KYO38058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMP1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="8440" checksum="F3009E783607BF2F" modified="2016-06-08" version="1">MYNCKENWVPLISWLRVDSLEILNSLILNNQDLSQCQLFWNWTACLYSLTTGTGVQRHWSSSNLPSPTAVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMU4</accession>
    <name>A0A151NMU4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002532">
        <property type="protein sequence ID" value="KYO38103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMU4"/>
    <dbReference type="STRING" id="8496.A0A151NMU4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29007" checksum="5935AE05605A422A" modified="2016-06-08" version="1">MQLNVPNGPQPPQNPPVVQWSHCKYYGLDQRAQKPGELYSPDTSAQASTQLSSPITSPTQSPTPSPVTSLSSVCPGLSPLPVLAQFPRPVGPAQGDGRYSLLGQPLQYNLALCPPPLLHSQPSYTSHQSQTGMKHGNRGKRQALKSASTDLGTSDVVPGRVLEVTDLPEGITRSEADKLFTQLAMAGAKIQWLKETRGRRGAGAGAGDGRVGPENGRHPDLAALYTVVAVFPSPLAAQNASLRLNTPLSRFRLRGAKRHYDLRVLERASSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNR7</accession>
    <name>A0A151NNR7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">VPS4B</name>
        <name evidence="17" type="ORF">Y1Q_0018075</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03002516">
        <property type="protein sequence ID" value="KYO38496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNR7"/>
    <dbReference type="STRING" id="8496.A0A151NNR7"/>
    <dbReference type="eggNOG" id="KOG0739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="159"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO38496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="463" mass="51204" checksum="DFE92D6ED6482F08" modified="2016-06-08" version="1">MTTSTLQKAIDLVTRATEEDKAKNYAEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKDKQSKKPVKEAQSDSKGSDSDSEGENPEKKKLQEQLMGAIMMEKPNVRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNSSDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQIFRLHLGNTPHSLSDTNIQELARKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRTNPNVTVDDLLTPCSPGDPGAIEMTWMEVPSDKLMEPTVCMSDMLRSLATTRPTVNAEDLLKAFCSTGAGSLPPVQAGEADLGSCLARVRRPVADGKATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNY2</accession>
    <name>A0A151NNY2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNY2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11791" checksum="A465D1DB8B44AFBD" modified="2016-06-08" version="1">MYKDEHELYWEPFWICKVTEDYTLFLVEENKTYAFLNSIFQNRCFGASDPFCMFGDTLYRHQAVMASEPPHKAFPALFGSSELTNCSRGNTALFRSFDYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNZ8</accession>
    <name>A0A151NNZ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc finger homeobox protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">AT motif-binding factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">AT-binding transcription factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Alpha-fetoprotein enhancer-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Zinc finger homeodomain protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">ZFHX4</name>
        <name evidence="31" type="ORF">Y1Q_0018091</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 25 26">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002516">
        <property type="protein sequence ID" value="KYO38518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NNZ8"/>
    <dbReference type="eggNOG" id="KOG1146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000082">
        <property type="entry name" value="Putative zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000317">
        <property type="entry name" value="zinc finger homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000378">
        <property type="entry name" value="zinc finger homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000058">
        <property type="entry name" value="zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000064">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000096">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF4">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24056">
        <property type="entry name" value="zf-C2H2_ZFHX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="27" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 25 26" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15 25 26" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="18 25 26" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="863"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="1048"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="1099"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="1485"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="29">
        <location>
            <begin position="1645"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="29">
        <location>
            <begin position="1742"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="1830"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="2033"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="29">
        <location>
            <begin position="2142"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="30">
        <location>
            <begin position="2214"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="29">
        <location>
            <begin position="2448"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="25">
        <location>
            <begin position="1647"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="25">
        <location>
            <begin position="1744"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="25">
        <location>
            <begin position="2144"/>
            <end position="2203"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="25">
        <location>
            <begin position="2450"/>
            <end position="2509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="643"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="800"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="993"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1132"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1364"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1532"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1706"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1857"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1917"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="2122"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="2272"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="2345"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="2416"/>
            <end position="2451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="2870"/>
            <end position="2909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="1222"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="2810"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="2923"/>
            <end position="3027"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="3056"/>
            <end position="3186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="3212"/>
            <end position="3355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="3402"/>
            <end position="3450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="3479"/>
            <end position="3527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="1007"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1135"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1364"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="1375"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="1536"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="1568"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="1709"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="1857"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1878"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1938"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1974"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="2345"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="2431"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="2885"/>
            <end position="2899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KYO38518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="3538" mass="393224" checksum="285F1C5E832BFB04" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPJ4</accession>
    <name>A0A151NPJ4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPJ4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="240" mass="26103" checksum="BFE78F4AF31DB293" modified="2016-06-08" version="1">MTWHTQGPIHGDWSPGWADSWDNWSLAAPPECHATPLEDPLGANCLTTQPGQGPIHHGLALSHLYCLLHCGDLNLPHLQAKTSVKMKIFFSVLNKHLLRQSGIYRNDEGSRQPRLILSPSWNCSLVTGTVVKYLCRVAPHPWLCLCPGSWWQLHHRESHAVGKECQKASVGNMSSALSLLSPSSAHVPTPILSAQAPNWTHEEAHNFVVTWGPTSGHRREAAGPCMSAAAGSPPPATRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NR68</accession>
    <name>A0A151NR68_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone-lysine N-methyltransferase 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0017276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002260">
        <property type="protein sequence ID" value="KYO39352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NR68"/>
    <dbReference type="STRING" id="8496.A0A151NR68"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19170">
        <property type="entry name" value="SET_KMT2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000004">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047219">
        <property type="entry name" value="KMT2A_2B_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838">
        <property type="entry name" value="HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00542">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="146"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO39352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32762" checksum="1C34EAC14360B45C" modified="2016-06-08" version="1">MWQGAWKAVIEKVQEARAVARLRHLSFAGMNGVRLLGMHHDAVVFLVEQLPGARTCHAYKFRYHPHGHGPAPPPLNPRGCARAEVYVRKCTFDMFNFLASQHRRLPEAGAEDEEEDEVQLKSTRRATSLELPMAMRFRHLKRTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGTVIRSVLTDKREKFYDSKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCYSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDAGSKLPCNCGAKRCRRYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NS10</accession>
    <name>A0A151NS10_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRMT2A</name>
        <name evidence="10" type="ORF">Y1Q_0018623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:42713"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NS10"/>
    <dbReference type="STRING" id="8496.A0A151NS10"/>
    <dbReference type="GeneID" id="102577307"/>
    <dbReference type="KEGG" id="amj:102577307"/>
    <dbReference type="CTD" id="27037"/>
    <dbReference type="eggNOG" id="KOG2187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NS10"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12439">
        <property type="entry name" value="RRM_TRMT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034262">
        <property type="entry name" value="TRMT2A_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO39523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="600" mass="67267" checksum="681AEAB261FDF82C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NT69</accession>
    <name>A0A151NT69_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002133">
        <property type="protein sequence ID" value="KYO39964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NT69"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO39964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="8687" checksum="D6B7530C4A0B4369" modified="2016-06-08" version="1">MLYTTALQLSIGKAAQPEALEAGLGLWKTLEGELEVATINIRKVDSSSMGPSLCLRINLESALSQTEHLFGLFLIMLLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTG5</accession>
    <name>A0A151NTG5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Dynein light chain Tctex-type 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Dynein light chain Tctex-type 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">DYNLT3</name>
        <name evidence="23" type="ORF">Y1Q_0000030</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002066">
        <property type="protein sequence ID" value="KYO40182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006277150.1">
        <property type="nucleotide sequence ID" value="XM_006277088.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTG5"/>
    <dbReference type="STRING" id="8496.A0A151NTG5"/>
    <dbReference type="GeneID" id="102572901"/>
    <dbReference type="KEGG" id="amj:102572901"/>
    <dbReference type="CTD" id="6990"/>
    <dbReference type="eggNOG" id="KOG4081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NTG5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21463">
        <property type="entry name" value="DLC-like_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000001">
        <property type="entry name" value="Dynein light chain Tctex-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF20">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="18" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0243">Dynein</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-0944">Nitration</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00072460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO40182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="116" mass="13081" checksum="157669A1F190771E" modified="2016-06-08" version="1">MEEFHPHNDEMIFNADEAHNIVKECIESILGKADYSHDKVNQWTATIVEQSLTHLVKLGKTYKYIVTCAVMQKSGAGLHTASSCFWDTTTDGTCTVRWENRTMNCIVNVFAVAIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU86</accession>
    <name>A0A151NU86_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0020194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002061">
        <property type="protein sequence ID" value="KYO40220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NU86"/>
    <dbReference type="eggNOG" id="KOG0517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1327"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1453"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="531"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO40220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1475" mass="166785" checksum="31EBD9A61FC1AA47" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUE1</accession>
    <name>A0A151NUE1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scale keratin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0024438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avian keratin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001982">
        <property type="protein sequence ID" value="KYO40270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUE1"/>
    <dbReference type="STRING" id="8496.A0A151NUE1"/>
    <dbReference type="KEGG" id="amj:102567958"/>
    <dbReference type="eggNOG" id="ENOG502TE1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9428763at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003461">
        <property type="entry name" value="Keratin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203:SF1">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02422">
        <property type="entry name" value="Keratin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0416">Keratin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO40270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="173" mass="17220" checksum="233EFAB41E5B4D5A" modified="2016-06-08" version="1">MSCTDLCYPSSGIACPRPYADSCNEACVRQCPDSRAVIQPPPVVVTFPGPILSNFPQDSIVGSVGVPTVGHGAAGGTALSNGTGGVGGIYGYGAYLGSGGLYDYGGSLVYGGGYGGSLGSGGLCGYRGSLGYGGPCGYGGLSSGSGSCYSSGYCSPYSYRRYGRYRYGSCGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWX3</accession>
    <name>A0A151NWX3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Unconventional myosin-XVI isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MYO16</name>
        <name evidence="11" type="ORF">Y1Q_0006153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NWX3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14878">
        <property type="entry name" value="MYSc_Myo16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000168">
        <property type="entry name" value="Myosin XVI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052838">
        <property type="entry name" value="Myosin-XVI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036042">
        <property type="entry name" value="MYSc_Myo16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039482">
        <property type="entry name" value="NYAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47335">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XVI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47335:SF1">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XVI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15439">
        <property type="entry name" value="NYAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="423"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1242"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1312"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1360"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1529"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1245"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1312"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1381"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1537"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1573"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="519"/>
            <end position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO41298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1672" mass="188338" checksum="9C6F800B81B80B57" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX15</accession>
    <name>A0A151NX15_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RTL1</name>
        <name evidence="11" type="ORF">Y1Q_0022530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03001669">
        <property type="protein sequence ID" value="KYO41119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX15"/>
    <dbReference type="STRING" id="8496.A0A151NX15"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="214"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO41119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="635" mass="73076" checksum="3D0CC4C641C1741F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX71</accession>
    <name>A0A151NX71_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">OCA2</name>
        <name evidence="8" type="ORF">Y1Q_0006275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX71"/>
    <dbReference type="STRING" id="8496.A0A151NX71"/>
    <dbReference type="eggNOG" id="KOG2639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="888"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="7">
        <location>
            <begin position="418"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO41476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="915" mass="102076" checksum="983EE7BBA4E851AE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXS9</accession>
    <name>A0A151NXS9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Gamma-aminobutyric acid receptor subunit alpha-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0006264</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXS9"/>
    <dbReference type="STRING" id="8496.A0A151NXS9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19038">
        <property type="entry name" value="LGIC_ECD_GABAAR_A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19052">
        <property type="entry name" value="LGIC_TM_GABAAR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000001">
        <property type="entry name" value="Gamma-aminobutyric acid A receptor subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000002">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit alpha-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005435">
        <property type="entry name" value="GABBAa5_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047024">
        <property type="entry name" value="Gabra-1-6_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01618">
        <property type="entry name" value="GABAARALPHA5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022251902" description="Gamma-aminobutyric acid receptor subunit alpha-5" evidence="18">
        <location>
            <begin position="26"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="50"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="285"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO41460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54295" checksum="F1881A31BA1F99AD" modified="2016-06-08" version="1">MDNGMFSSFIMIKNFILFCISMSLANHFGLSQMPTPSGKDDTNDNITIFTRILDGLLDGYDNRLRPGLGERITQVKTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLQFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVIYVWTNSTTTSVVVAEDGSRLNQYHLIGQTVGTENISTSTESDKPEEGSSPRTKAEAVSTLGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWDGKKALEAAKIKKKERELHANKAINASSTGKTIPTPNMPKDSIPSVISNSASAPVKPVEEKPPESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY01</accession>
    <name>A0A151NY01_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NUDT3</name>
        <name evidence="11" type="ORF">Y1Q_0002444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.</text>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DIPP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03001615">
        <property type="protein sequence ID" value="KYO41751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276153.1">
        <property type="nucleotide sequence ID" value="XM_006276091.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY01"/>
    <dbReference type="STRING" id="8496.A0A151NY01"/>
    <dbReference type="GeneID" id="102566648"/>
    <dbReference type="KEGG" id="amj:102566648"/>
    <dbReference type="CTD" id="11165"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NY01"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000002">
        <property type="entry name" value="diphosphoinositol polyphosphate phosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF5">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO41751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="169" mass="19314" checksum="3E4BBC3543960ACF" modified="2016-06-08" version="1">MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPNMAAVREVCEEAGVKGTLGRLVGIFENRDRKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQCHKPVQASYFETLRQGCLANNGTPVMTTTYSESSMSDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYI6</accession>
    <name>A0A151NYI6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase lipid-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATPase protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ATP5G2</name>
        <name evidence="18" type="ORF">Y1Q_0002609</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO41941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYI6"/>
    <dbReference type="STRING" id="8496.A0A151NYI6"/>
    <dbReference type="eggNOG" id="KOG3025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF59">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT C3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="17">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO41941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="257" mass="26782" checksum="6E4AA31A13DEA3F6" modified="2016-06-08" version="1">MPSRLSGGSGFYLATLPLHRPPWGNAIGSSPHVCHPNRPTMYACTKLIALPVLVRTGPRLLYRPLSASLLSRPEAPTQELCPVPLSSPLLQAARRELHASTVCRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAMGAINTVRKPAIVRQGFLPSTKRPGIPLTGSSCGSGSKASLLTREAILPSVTAPWACQQLGLCQSSLSQKEGNTEAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYW3</accession>
    <name>A0A151NYW3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Opioid growth factor receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">OGFR</name>
        <name evidence="4" type="ORF">Y1Q_0002636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO41978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014465242.1">
        <property type="nucleotide sequence ID" value="XM_014609756.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYW3"/>
    <dbReference type="STRING" id="8496.A0A151NYW3"/>
    <dbReference type="GeneID" id="102570610"/>
    <dbReference type="KEGG" id="amj:102570610"/>
    <dbReference type="CTD" id="11054"/>
    <dbReference type="eggNOG" id="ENOG502QVIF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF1">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="112"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO41978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="672" mass="76307" checksum="46A58735099D234F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3M5</accession>
    <name>A0A151P3M5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3M5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="158" mass="17235" checksum="9D10279F2F0F91EE" modified="2016-06-08" version="1">MTRKRYSASFRISPKSKHHITVEQLHPLNGDADTVAAVAFDMEVTSHSYYSPISKAEVTVIGQGRTFSPSQSAWCGCGLGIELLLAVVKARATTRQPTLRGSVPGYGLVVGNLCTAELCIYDLNSCYGSGREICLRNFLMSITTIMFKSLSPIQPFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4R7</accession>
    <name>A0A151P4R7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0020668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000970">
        <property type="protein sequence ID" value="KYO44048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4R7"/>
    <dbReference type="STRING" id="8496.A0A151P4R7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF12">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II elongation factor ELL N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO44048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="218" mass="24183" checksum="24CB3455E949FF4A" modified="2016-06-08" version="1">MDPQALARYLVQLLAPRPQHKHELLARLERTRGSLQNGAQLLAVLEQVAQPEPGGHRYRLREELLGQVQEDWPGYTPAERQLLAQLLHRKQELGAWAGPSLVPRQEGAETPAQQNTGKKPWGMKRLALPASCRPPQLKRARVAEASLESCPGSLQEPRPEPARAQPQPEQPSRPSTPGETSSSEEASEDWEEGTLCLEQDLAVLGGEWLHPRGRQPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P660</accession>
    <name>A0A151P660_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000764">
        <property type="protein sequence ID" value="KYO44460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P660"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="9394" checksum="3802E7EA3CB543D7" modified="2016-06-08" version="1">MPVKQRMMPPPNHWLPWQKAKRTVRMTTGEAEKMTDEPPRRDEKHLSPTSRKSTPKEKQQTGNGPGIWEKKKTSMKQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7Y0</accession>
    <name>A0A151P7Y0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CYRIA/CYRIB Rac1 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0014652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYRI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7Y0"/>
    <dbReference type="STRING" id="8496.A0A151P7Y0"/>
    <dbReference type="eggNOG" id="KOG3951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039789">
        <property type="entry name" value="CYRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12422">
        <property type="entry name" value="GH09096P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="5">
        <location>
            <begin position="62"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO45186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="368" mass="41363" checksum="7121FFCA194F4E3D" modified="2016-06-08" version="1">MHKSSGQAATSVLQGVEASIKTSRGYCQLPGGQEKSSTGCRYLNMGNLLKVLTCTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPSDEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRINNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P819</accession>
    <name>A0A151P819_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P819"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="8197" checksum="BE020092DE2FBEB2" modified="2016-06-08" version="1">MWCSAQEIHRRESLPEGRDGRWIEQISVWESRGSRTADLICSVDRSDKAPFIWTLPSDVLAGIIAEVLKQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8F9</accession>
    <name>A0A151P8F9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc phosphodiesterase ELAC protein 2</fullName>
            <ecNumber evidence="6">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">ElaC homolog protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ribonuclease Z 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">tRNA 3 endonuclease 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">tRNase Z 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">ELAC2</name>
        <name evidence="27" type="ORF">Y1Q_0007327</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with PTCD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
            <location evidence="4">Mitochondrion nucleoid</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8F9"/>
    <dbReference type="STRING" id="8496.A0A151P8F9"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151P8F9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000014">
        <property type="entry name" value="Zinc phosphodiesterase ELAC protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="26">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="781"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00032616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00046098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO45015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="821" mass="92108" checksum="BA49012DF614C043" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8I9</accession>
    <name>A0A151P8I9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000600">
        <property type="protein sequence ID" value="KYO45344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8I9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="8352" checksum="F70478F1483ACDA1" modified="2016-06-08" version="1">MVLWVSQGLMETVTQDEEPNRILCNSIAAICSLSELKPALEPAMESCLVQTTLKICLMSPRHNSLYVRPRAAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9M6</accession>
    <name>A0A151P9M6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9M6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10531" checksum="2186717E9B712899" modified="2016-06-08" version="1">MMAKMTTNMAVRGEPSDVIRACDGQDFLFQGQKHPKMENLQRKRQGFWRQSLLCSRPHGPPGLELEVLRPWSSSEITGKWPQQHPARYQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9R5</accession>
    <name>A0A151P9R5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Max dimerization protein 4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MXD4-1</name>
        <name evidence="10" type="ORF">Y1Q_0021340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9R5"/>
    <dbReference type="STRING" id="8496.A0A151P9R5"/>
    <dbReference type="GeneID" id="102568055"/>
    <dbReference type="KEGG" id="amj:102568055"/>
    <dbReference type="CTD" id="10608"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P9R5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18929">
        <property type="entry name" value="bHLHzip_Mad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000014">
        <property type="entry name" value="Max dimerization protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF4">
        <property type="entry name" value="MAX DIMERIZATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO45659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="205" mass="23604" checksum="47F5311CB7683882" modified="2016-06-08" version="1">MELNSLLILLEAAEYLERRDREAEHGYASVLPFDSDYSRKKSKAGPMARKSQSNRSSHNELEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKMHIKKLEEQDRKALNIKEQLQREHRYLKRRLEQLSMQGMERIRTDSMGSTISTDSEQEVDIEGMEFTPGEMDSIGSASDAEDHYSLQSGSSDGGYTHSRRLNARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PA49</accession>
    <name>A0A151PA49_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0021443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PA49"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO45799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="164" mass="18176" checksum="2138B58EB04FE563" modified="2016-06-08" version="1">MLTEGRHIFGTLHELGLPDGLIDLVRELYHGCTTAVHATDRVTAEIPIWSGVRQGYPLSPIIFSLDTEMLLRAMAVSSGGLDLYSQKLSVLAYTDDLILLAPDATQLQQMLDVTSEVARWMGLHFNVTKCASLHIDGRQNSHILDSTLMIQGQARHEPPPYPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PB90</accession>
    <name>A0A151PB90_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PB90"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7692" checksum="A4B99E128C3AA949" modified="2016-06-08" version="1">MRLQSSTRYGTNLKRFLSTLTKCIKQKHASPSCTVFYDPLDCNLGWNFQERLEEQNSEDGKRPPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCP8</accession>
    <name>A0A151PCP8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FKBP2</name>
        <name evidence="8" type="ORF">Y1Q_0015758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="AKHW03000489">
        <property type="protein sequence ID" value="KYO46760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCP8"/>
    <dbReference type="STRING" id="8496.A0A151PCP8"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF3">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586908" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO46760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="130" mass="14130" checksum="FAF1627F2801AA75" modified="2016-06-08" version="1">MQLWLGLALWLGALGPLLAPGSAGAEGPRKLQIGVKRRVENCGLRSRKGDVLTMHYTGRLEDGSEFDSSLGRAQPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGGATLVFEVELLKIERRPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCW6</accession>
    <name>A0A151PCW6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Abl interactor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ABI2</name>
        <name evidence="15" type="ORF">Y1Q_0014420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCW6"/>
    <dbReference type="STRING" id="8496.A0A151PCW6"/>
    <dbReference type="eggNOG" id="KOG2546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11971">
        <property type="entry name" value="SH3_Abi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000002">
        <property type="entry name" value="abl interactor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028457">
        <property type="entry name" value="ABI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035725">
        <property type="entry name" value="Abi1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012849">
        <property type="entry name" value="Abl-interactor_HHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460:SF2">
        <property type="entry name" value="ABL INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460">
        <property type="entry name" value="ABL INTERACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07815">
        <property type="entry name" value="Abi_HHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="401"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO46820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="463" mass="50512" checksum="C449271A86909DB2" modified="2016-06-08" version="1">MAELQMLLEEEIPVGKRALLESYQNLTRVADYCENNYIQAPDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKHGSNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSASSGGYRRNPSVTVPFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENNEMPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE20</accession>
    <name>A0A151PE20_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000474">
        <property type="protein sequence ID" value="KYO47209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PE20"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO47209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="276" mass="30686" checksum="C4AD390B11780834" modified="2016-06-08" version="1">MQKAQLRCLLFPWKSMPGTTSMAGAEGKGRSQQTAKPRPVHPPVPHFIEGPIPREAEAGLVDAVRFMYLELYTTVAGDCICGAEIGKAHDETTRKGTSGGARSPGAERENTPAALRTWCQQGPSVPHGQNKIPIADTHIAPGKQRHGWEAMLYLVHLSYWQDRHEKEDSMNSPETKEIIQVHSRVKKTCQGSHQRELNYSQQGLRGERGTSREKLNVWMENLITKEKQGWLGKECPEEMPLAWDSGGLDLFSSLVTISLRCPGEFPPHALKGRHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEG3</accession>
    <name>A0A151PEG3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histone-lysine N-methyltransferase 2B isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">KMT2B</name>
        <name evidence="13" type="ORF">Y1Q_0016918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000417">
        <property type="protein sequence ID" value="KYO47461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEG3"/>
    <dbReference type="STRING" id="8496.A0A151PEG3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000071">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000089">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838">
        <property type="entry name" value="HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="86"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="220"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="463"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO47461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="615" mass="68324" checksum="4824AE26DCBFBF23" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFH7</accession>
    <name>A0A151PFH7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CutA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0018544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000406">
        <property type="protein sequence ID" value="KYO47857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFH7"/>
    <dbReference type="STRING" id="8496.A0A151PFH7"/>
    <dbReference type="KEGG" id="amj:102562499"/>
    <dbReference type="eggNOG" id="KOG3338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017693at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="DIVALENT CATION TOLERANCE CUTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419:SF1">
        <property type="entry name" value="PROTEIN CUTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586974" evidence="4">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO47857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="108" mass="11873" checksum="05AF8A42F194B890" modified="2016-06-08" version="1">MKAACCVLVVSLLMVPLLRTVSQRLFSMAAESYAPGSLSAAFITCPNETVAKEIARAVVEKHLAACVNIMPQITSIYEWKGKIEEDSEVLLMIKTRSSRIPALAEYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFX5</accession>
    <name>A0A151PFX5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFX5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="155" mass="17958" checksum="41A13484F9A74E70" modified="2016-06-08" version="1">MPCPPTLSKNPQLKNLSLPCTGPSWWHIWFKSVNGFHICYRNQDQNTSLKFLLENLAFAYLRVHEVLATKRNEEVIGPPCVFKIHMEVMLRKGSNRLLERSWSFFISKERFSNIPGIENFCEWNLLGAASSTQLSDKKIRVKIVKRSTVKISSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ68</accession>
    <name>A0A151PJ68_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000111">
        <property type="protein sequence ID" value="KYO49069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ68"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO49069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10258" checksum="4C2C0579CA83E729" modified="2016-06-08" version="1">MRERLSVRRGPTEREDGMPSSHRLGGDYKVYDSAPLNYSLRPFKDMQTLKDTDKRLSKANPAPFCIGTFRNGPEDSDSSLHMEKAAPSPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJJ5</accession>
    <name>A0A151PJJ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000012">
        <property type="protein sequence ID" value="KYO49162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJJ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO49162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9583" checksum="C0EA91029982D700" modified="2016-06-08" version="1">MRFATVTETAIVTLETCFSVIIAIEIGGLICLIVIGIAIYKGVNILFSQLMIPLETQKAGQKADEVSHSPQKRNRIPLKMETGSCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0R0</accession>
    <name>A0A151M0R0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 163</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TMEM163</name>
        <name evidence="14" type="ORF">Y1Q_0011688</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM163 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0R0"/>
    <dbReference type="GeneID" id="102565484"/>
    <dbReference type="KEGG" id="amj:102565484"/>
    <dbReference type="CTD" id="81615"/>
    <dbReference type="eggNOG" id="ENOG502QW7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5980560at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M0R0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000018">
        <property type="entry name" value="transmembrane protein 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO18101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="269" mass="28823" checksum="1F031797AE6CD585" modified="2016-06-08" version="1">MQPPAAGGDPAGTPQPAIVQPPGASPPGADQLRLGDGAQFSEGLEDRGLLESSTRLKPHEAQSYRKKALWVSGVSIIITLALAVAAFTVSIMRYSASSFGFAFDATLDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLANKLLPEVDDFLYSVSVLSGILCSILAVIKFMLGRVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHNASVWYLDGSIGVLIGLTILAYGIKLLIDMVPRVRQTRHYEMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4K6</accession>
    <name>A0A151M4K6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carnitine O-palmitoyltransferase 1, muscle isoform</fullName>
            <ecNumber evidence="4">2.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Carnitine O-palmitoyltransferase I, muscle isoform</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Carnitine palmitoyltransferase 1B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CPT1A</name>
        <name evidence="23" type="ORF">Y1Q_0015799</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12661"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17490"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="2.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:12662"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03006603">
        <property type="protein sequence ID" value="KYO19465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4K6"/>
    <dbReference type="STRING" id="8496.A0A151M4K6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015909">
        <property type="term" value="P:long-chain fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000001">
        <property type="entry name" value="Carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000042">
        <property type="entry name" value="Carnitine Palmitoyl Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF69">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 1, MUSCLE ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="22">
        <location>
            <begin position="39"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO19465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="638" mass="72942" checksum="24723890C55D880B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4S7</accession>
    <name>A0A151M4S7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006584">
        <property type="protein sequence ID" value="KYO19529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4S7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9857" checksum="0273A7B2BCC94646" modified="2016-06-08" version="1">MEMKVLFLLHYLNYHGEDYKQRVLNSEEKNKKQATGELNTDSSSLYTKSESSKKHSLHLRTRLPFSPLAMERATDTKPHFEQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6T6</accession>
    <name>A0A151M6T6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AF4/FMR2 family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AFF1L</name>
        <name evidence="7" type="ORF">Y1Q_0010793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="8496.A0A151M6T6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2670">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AF4/FMR2"/>
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    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043639">
        <property type="entry name" value="AF4_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528">
        <property type="entry name" value="AF4/FMR2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528:SF15">
        <property type="entry name" value="AF4_FMR2 FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05110">
        <property type="entry name" value="AF-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18875">
        <property type="entry name" value="AF4_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="6">
        <location>
            <begin position="1001"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1137"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="526"/>
            <end position="558"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="646"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="664"/>
            <end position="682"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="695"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="825"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="874"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="938"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1165"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO20242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139395" checksum="37601AED9A22BF0A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6V2</accession>
    <name>A0A151M6V2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Actin-binding LIM protein 1 isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ABLIM1-1</name>
        <name evidence="12" type="ORF">Y1Q_0010737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A151M6V2"/>
    <dbReference type="STRING" id="8496.A0A151M6V2"/>
    <dbReference type="eggNOG" id="KOG1044">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09327">
        <property type="entry name" value="LIM1_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09328">
        <property type="entry name" value="LIM2_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09329">
        <property type="entry name" value="LIM3_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09330">
        <property type="entry name" value="LIM4_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000003">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000004">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000007">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000024">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.950.10:FF:000001">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF0">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="HP" evidence="11">
        <location>
            <begin position="585"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="506"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO20170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="653" mass="74184" checksum="2C2A5E1C3B9A2785" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9S6</accession>
    <name>A0A151M9S6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase II subunit GRINL1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-directed RNA polymerase II subunit M</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamate receptor-like protein 1A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">POLR2M</name>
        <name evidence="12" type="ORF">Y1Q_0001518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GRINL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9S6"/>
    <dbReference type="STRING" id="8496.A0A151M9S6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016591">
        <property type="term" value="C:RNA polymerase II, holoenzyme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026213">
        <property type="entry name" value="GRINL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051375">
        <property type="entry name" value="Tuftelin_GRINL1A/MYZAP/CCD68"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT GRINL1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171">
        <property type="entry name" value="GDOWN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15328">
        <property type="entry name" value="GCOM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02085">
        <property type="entry name" value="POLR2GRINL1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO21264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="368" mass="41018" checksum="3B12754C1B52FD98" modified="2016-06-08" version="1">MLRRQQRLLADRKFINRLPDKGKKISDFAEKLKHVIAQEEEVMRTTKLLSTVRLEFQARREEINTSKLNENKLISEAFAAINENSSIDVNGSKVVLQNQEAELTRQRLADAASKDEKGHGKSDEIKSSVESPTKVPLGDEIRPQSSTANLLKTDQQTSPSSSMAGTEGAAEMPGNSGSALVDAFQSFTIVHEDNSEGTSEKEQHVSAVKENPFGSLHTRLPKKLHYIEILESRAKNPVAKKPKFKTNILLSELSGSSQGSSPDHSPGGLGSPISAEERRLRDKKHLNDVTAARLPPLHHEPTQLLSTEESISIQIKQKEVYEEMQAKLAAQKLAERLNIKMVKYEPEGEASKQYREVRDEEDCFSTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAM1</accession>
    <name>A0A151MAM1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Interaptin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0001711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAM1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="407"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="624"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="829"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="917"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO21529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1275" mass="145452" checksum="560583788D45B95A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCK5</accession>
    <name>A0A151MCK5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Semaphorin-6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0000315</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006238">
        <property type="protein sequence ID" value="KYO22234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCK5"/>
    <dbReference type="STRING" id="8496.A0A151MCK5"/>
    <dbReference type="KEGG" id="amj:102561136"/>
    <dbReference type="eggNOG" id="KOG3611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000009">
        <property type="entry name" value="Semaphorin 6B isoform 3 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000028">
        <property type="entry name" value="semaphorin-6A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF10">
        <property type="entry name" value="SEMAPHORIN-6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584987" description="Semaphorin-6B" evidence="19">
        <location>
            <begin position="22"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="20">
        <location>
            <begin position="27"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="767"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO22234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="913" mass="99773" checksum="4EAFCEC62B682163" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEM9</accession>
    <name>A0A151MEM9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SH3 domain-binding glutamic acid-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SH3BGR</name>
        <name evidence="4" type="ORF">Y1Q_0003320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEM9"/>
    <dbReference type="STRING" id="8496.A0A151MEM9"/>
    <dbReference type="eggNOG" id="KOG4023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03030">
        <property type="entry name" value="GRX_SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585066" evidence="3">
        <location>
            <begin position="25"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO22850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="196" mass="22405" checksum="6F95A95687B91694" modified="2016-06-08" version="1">MGFIFIVARMVIKVFVATICGSTAIKKKQQEVLGFLEANKIDFQPLDIAGDEDNRKWMRENVPGEKKPQNGIPLPPQIFNEEQYCGDFESFFSAKEENIIYSFLGLAPPPGTKEVKIDEEISDLPNGEVSGEEQKTVEEAEKLEVTEENEEHTEDNADAEVHDTEAPSEEQEEEKEEHTVTEFFRKHMPVQQHHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF29</accession>
    <name>A0A151MF29_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0005584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF29"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585114" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO23136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="157" mass="15990" checksum="362FE73ECE740A6A" modified="2016-06-08" version="1">MGRAAQQTLLALLCLMAAVCTATEKRLARRDSPQHEGDVGHPGRPGLPGPPGPPGPPGPPGPPGFHGIPGQPGPPGPAGRPGFPGPPGIPGPPGARGPPGPPGPPGEKGVKNCKELLARGYMLSGWYTIYPQESKAMTVMCDMHTDGGGWIVSKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF57</accession>
    <name>A0A151MF57_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF57"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8515" checksum="4C8D4ACAE440AEDA" modified="2016-06-08" version="1">MSYHKILVYVSCKSVSHQPRYCQPSLSVDPSPGSDQLGAGQFPAHTSLAGCGRLLGHLFLRSTRQQRRLQQQKCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHH9</accession>
    <name>A0A151MHH9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptonemal complex central element protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SYCE1L</name>
        <name evidence="5" type="ORF">Y1Q_0004585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SYCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO23986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHH9"/>
    <dbReference type="STRING" id="8496.A0A151MHH9"/>
    <dbReference type="eggNOG" id="ENOG502S24D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151MHH9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026676">
        <property type="entry name" value="SYCE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21731">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21731:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15233">
        <property type="entry name" value="SYCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="109"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO23986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="274" mass="31768" checksum="76E3A9AF5D3B5AF0" modified="2016-06-08" version="1">MAKKGEDLGPKAEELLLLVKQLQKAGDLEPRIEDLVSRINKLQQAKQTLSTELGEARERSEDLWMELEELTKEQTNLEDIHWQKEEALRVAQVQCQEAESESHRQHGLLQEVQQRIQDLTMGIQEETLKQRKQRLEFEQQLDELMEKHKTLQEGHTMDKLAVEIQNMSDSWERLLREDELIQAKLMQLKQKLYVLAQAGAGRREERRFLKSPEASAALQLLQQENQGAHSQLEVATQRHCQGLQRCNRLKVELEGQGWRSSTSQLAPRDQKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHU0</accession>
    <name>A0A151MHU0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0021945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006136">
        <property type="protein sequence ID" value="KYO24092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHU0"/>
    <dbReference type="eggNOG" id="ENOG502S0VI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000013">
        <property type="entry name" value="CD163 molecule like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000031">
        <property type="entry name" value="RIKEN cDNA 5830411N06, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000004">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF22">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585174" description="SRCR domain-containing protein" evidence="10">
        <location>
            <begin position="29"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="74"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="283"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="388"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO24092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="653" mass="70682" checksum="1BF7242D889DECF8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MI21</accession>
    <name>A0A151MI21_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Forkhead box protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FOXS1</name>
        <name evidence="9" type="ORF">Y1Q_0020278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006102">
        <property type="protein sequence ID" value="KYO24164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259141.2">
        <property type="nucleotide sequence ID" value="XM_006259079.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MI21"/>
    <dbReference type="STRING" id="8496.A0A151MI21"/>
    <dbReference type="GeneID" id="102560985"/>
    <dbReference type="KEGG" id="amj:102560985"/>
    <dbReference type="CTD" id="2307"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20037">
        <property type="entry name" value="FH_FOXS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047364">
        <property type="entry name" value="FH_FOXS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF370">
        <property type="entry name" value="FORKHEAD BOX PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO24164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="485" mass="52390" checksum="DE6C03F82690684F" modified="2016-06-08" version="1">MQLEYPAPASSLRVPPEPGACSNLGMVLAPYAGSTAGSGQAPAGEAAKPPYSYIALITMAIQSTPEKRITLNGIYRYIMGHFTFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGNYWTLDPDCYNMFENGSFLRRRRRFTRKRGRGDAPGTEAEETRKKPSKPRTRQVPPAPAPAPAPAPEIKTEGGYSPLEPSGASQMLSGEAQGDAKERAQSSVDPGARCPEQPRKYLQKPRQACLYLPEGPEPKPQLFKEPCYPLPESRGQELPLLKEPIFGGLQPHIPMPRLSPYTSPGERLSQPAPEIKDSLPDAVLAESALETKEPAAPALGLAQPFSQVAPGFATPLLGPGKAPLPCGRQPSPACFPGFEGEAYVKPALPMFGSFGCAGTDALSGNYQCRVQALSFCMNERPCSSALEHILSSAQPGGPGAPVQPPPFHPALQLPGDQKESWPGGAFPLQGGNSYHLGLPKCIYRTPGMFFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIU8</accession>
    <name>A0A151MIU8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GTPase IMAP family member GIMD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GIMD1</name>
        <name evidence="1" type="ORF">Y1Q_0002075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006071">
        <property type="protein sequence ID" value="KYO24455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIU8"/>
    <dbReference type="STRING" id="8496.A0A151MIU8"/>
    <dbReference type="eggNOG" id="ENOG502S1B7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="10242" checksum="D660478B73C34F02" modified="2016-06-08" version="1">MLQELLGPTWKNFTAVFLTHTDKVEEAGFSEEEYLHAASDTLLTLLSSVQHKYIFVENKAHTLKQKRVTILRKIMDFIRQNSYQASIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKV8</accession>
    <name>A0A151MKV8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bone morphogenetic protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GDF10</name>
        <name evidence="15" type="ORF">Y1Q_0001790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005917">
        <property type="protein sequence ID" value="KYO25164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276241.2">
        <property type="nucleotide sequence ID" value="XM_006276179.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKV8"/>
    <dbReference type="STRING" id="8496.A0A151MKV8"/>
    <dbReference type="GeneID" id="102567486"/>
    <dbReference type="KEGG" id="amj:102567486"/>
    <dbReference type="CTD" id="2662"/>
    <dbReference type="eggNOG" id="KOG3900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MKV8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19394">
        <property type="entry name" value="TGF_beta_GDF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000008">
        <property type="entry name" value="Bone morphogenetic protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017197">
        <property type="entry name" value="BMP3/BMP3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF145">
        <property type="entry name" value="GROWTH_DIFFERENTIATION FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037403">
        <property type="entry name" value="BMP3/GDF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3 10" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10 12" id="KW-0339">Growth factor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007366578" description="Bone morphogenetic protein 3" evidence="10">
        <location>
            <begin position="29"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="14">
        <location>
            <begin position="346"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="356"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="385"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="389"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="11">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO25164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="458" mass="51780" checksum="F93717DBA2AC6B50" modified="2016-06-08" version="1">MPPACPPMAGRLACCLLLGLLGRGGCHALPAREEPRAPDFSPAGTHPRGDAALGGIARDVVAVHMLKLYERYNREGSRPGDGNTVRSFRARLELLSQKPLYCFNLTSMQDSEMILAATFHFYSDKRPRHQEVFCKRSKNSSCRLLHLPQIPRLNLIFRSIPQNSAYGLVKGNVTVFPQRRGSWQVKDISHIINESKLAGELILCAELDSGEKYQGIPEQVARHFPYILVYANDLAIAEPNSVAVTLQRYDPFPSSDGDPSLSPNASSDTRVRRDTYLSSSIQNNELPEVEYINNDYNKHDIWESAYKSLKPRTSRKDRRRKGHENTETLTKSQMLNFDEKTMKKARRKQWNEPRICSRRYMKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVKAVGIIPGIPEPCCVPDKMNSLSVLFLDENKNVVLKVYPNMSVETCACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLW7</accession>
    <name>A0A151MLW7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0023954</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005753">
        <property type="protein sequence ID" value="KYO25515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLW7"/>
    <dbReference type="PhylomeDB" id="A0A151MLW7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000144">
        <property type="entry name" value="zinc finger protein 181 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000247">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO25515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="346" mass="39714" checksum="4A5122B2DD1A3642" modified="2016-06-08" version="1">MSPKKSKANMAKNLEKKKPTKNKRKSEKPKRSPPEEETIVYQPPPKGDRPNLCSECGKSFLHSSDLVNHQRIHTGDKPFICTDCGKSFRQSSTLITHQRIHTGETPYECSYCGKSFRVSSNFVRHQRIHTGEKPYKCPICGKSFTDKSTLTQHQRTHTGEKPYKCADCGKSFSRSSHRKRHLRNPPAKGRGKCMHRGTEGTPPKPKEIKVKKKTPTLEVPNTCAECWQTFTQNSDLVKHMRIHTGEKPFTCTHCGKRFSVSSNLTRHQRIHTGEKPYKCPDCGKCFTDKSTLTQHQRIHTGEKPYICIYCGKSFSRSSHHKRHERTHSGENNDTFLPLWHYPTPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNN2</accession>
    <name>A0A151MNN2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Microtubule-associated protein RP/EB family member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MAPRE2</name>
        <name evidence="14" type="ORF">Y1Q_0003893</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276202.1">
        <property type="nucleotide sequence ID" value="XM_006276140.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNN2"/>
    <dbReference type="STRING" id="8496.A0A151MNN2"/>
    <dbReference type="GeneID" id="102557981"/>
    <dbReference type="KEGG" id="amj:102557981"/>
    <dbReference type="CTD" id="10982"/>
    <dbReference type="eggNOG" id="KOG3000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000002">
        <property type="entry name" value="microtubule-associated protein RP/EB family member 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000007">
        <property type="entry name" value="Microtubule-associated protein, RP/EB family, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="13">
        <location>
            <begin position="235"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO26148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="325" mass="36881" checksum="9D5D4B52DE7FE8E6" modified="2016-06-08" version="1">MPGPTQALSPNGENNNDIIQDNGTIIPFRKHTVRGERSYSWGMAVNVYSTSITQETMSRHDIIAWVNDILALNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFFDANYDGKEYDPVEARQGQDALPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPASKPGSTPSRPSSAKKATPSSSVSKSDKDLETQVIQLSEQVHTLKLALEGVEKERDFYFGKLREIELLCQEHGQENNDLVQRLMEVLYASEEHESHTEEHEGEEQVHEQPPQQEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPK7</accession>
    <name>A0A151MPK7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">Y1Q_0015393</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>D-serine(in) + L-alanine(out) + Na(+)(out) = D-serine(out) + L-alanine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75311"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75307"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-asparagine(in) + L-glutamine(out) + Na(+)(out) = L-asparagine(out) + L-glutamine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70859"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-asparagine(out) + L-glutamine(in) + Na(+)(out) = L-asparagine(in) + L-glutamine(out) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70891"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-glutamine(in) + L-alanine(out) + Na(+)(out) = L-glutamine(out) + L-alanine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70867"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-glutamine(in) + L-glutamate(out) + Na(+)(out) + H(+)(out) = L-glutamine(out) + L-glutamate(in) + Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70883"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-glutamine(in) + L-methionine(out) + Na(+)(out) = L-glutamine(out) + L-methionine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70875"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamine(in) + L-serine(out) + Na(+)(out) = L-glutamine(out) + L-serine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70887"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-glutamine(out) + L-serine(in) + Na(+)(out) = L-glutamine(in) + L-serine(out) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70855"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70863"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-threonine(out) + L-glutamine(in) + Na(+)(out) = L-threonine(in) + L-glutamine(out) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70879"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-valine(out) + L-glutamine(in) + Na(+)(out) = L-valine(in) + L-glutamine(out) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70871"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>nitrate(in) = nitrate(out)</text>
            <dbReference type="Rhea" id="RHEA:34923"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>thiocyanate(in) = thiocyanate(out)</text>
            <dbReference type="Rhea" id="RHEA:75347"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="31">Membrane</location>
            <topology evidence="31">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="31">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005481">
        <property type="protein sequence ID" value="KYO26471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPK7"/>
    <dbReference type="STRING" id="8496.A0A151MPK7"/>
    <dbReference type="eggNOG" id="KOG3787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140009">
        <property type="term" value="P:L-aspartate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF19">
        <property type="entry name" value="NEUTRAL AMINO ACID TRANSPORTER B(0)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="9 31" id="KW-0769">Symport</keyword>
    <keyword evidence="7 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 31" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 31" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00036948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KYO26471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="263" mass="28732" checksum="489F38A8A4FB77BE" modified="2016-06-08" version="1">MGGSCSLVLSVPLNALFSSHRNIFPSNLVSATFRSYATSYKLVEIKKNITDELGVINETVVVEKVPWGEEVEGMNILGLVVFAIVFGIALRKLGPEGENLIQFFNSFNEATMVLVSWIMWYAPLGIMFLVAGKIVEMEDVAALFASLGKYIASCIVGHVIHGLLVLPGIYFIFTRRNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVSKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNNISLDFIQIITIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQ05</accession>
    <name>A0A151MQ05_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Multidrug resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0019105</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQ05"/>
    <dbReference type="STRING" id="8496.A0A151MQ05"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000046">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000083">
        <property type="entry name" value="phosphatidylcholine translocator ABCB4 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="209"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="452"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="712"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO26614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="106039" checksum="A84BE954FCF7A6F6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR80</accession>
    <name>A0A151MR80_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Double-stranded RNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADAR</name>
        <name evidence="11" type="ORF">Y1Q_0015269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005445">
        <property type="protein sequence ID" value="KYO27012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014458886.1">
        <property type="nucleotide sequence ID" value="XM_014603400.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014458887.1">
        <property type="nucleotide sequence ID" value="XM_014603401.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR80"/>
    <dbReference type="STRING" id="8496.A0A151MR80"/>
    <dbReference type="GeneID" id="102575445"/>
    <dbReference type="CTD" id="103"/>
    <dbReference type="eggNOG" id="KOG2777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19913">
        <property type="entry name" value="DSRM_DRADA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19915">
        <property type="entry name" value="DSRM_DRADA_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000005">
        <property type="entry name" value="Putative double-stranded RNA-specific adenosine deaminase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044456">
        <property type="entry name" value="ADAR1_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044457">
        <property type="entry name" value="ADAR1_DSRM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042371">
        <property type="entry name" value="Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF107">
        <property type="entry name" value="DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02295">
        <property type="entry name" value="z-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00550">
        <property type="entry name" value="Zalpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50139">
        <property type="entry name" value="Z_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Z-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Z-binding" evidence="9">
        <location>
            <begin position="109"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="344"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="459"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="579"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="10">
        <location>
            <begin position="716"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO27012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1059" mass="116319" checksum="590CF83F73D72BCD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRH0</accession>
    <name>A0A151MRH0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-binding protein 5</fullName>
            <shortName evidence="3">SH3BP-5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SH3BP5</name>
        <name evidence="6" type="ORF">Y1Q_0019404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Functions as guanine nucleotide exchange factor (GEF) for RAB11A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with GDP-bound and nucleotide-free forms of RAB11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Colocalizes with RAB11A on cytoplasmic vesicle membranes.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SH3BP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO27000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258194.1">
        <property type="nucleotide sequence ID" value="XM_006258132.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRH0"/>
    <dbReference type="STRING" id="8496.A0A151MRH0"/>
    <dbReference type="GeneID" id="102570683"/>
    <dbReference type="KEGG" id="amj:102570683"/>
    <dbReference type="CTD" id="9467"/>
    <dbReference type="eggNOG" id="KOG2008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446789at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MRH0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="169"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO27000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="432" mass="47739" checksum="431CD01805EFC5BA" modified="2016-06-08" version="1">MEPAARRSRPGEEGDLPQEAAAVAAEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAAKYNAAMGRMKQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKTALKNLEMISDEIHERRRSAAMGPRGCGVGAEGSNTSVENLSASKLEADTISIASEVFEDDNCSSFVSEEDSETQSVSSFSSGPTSPCEIPTQFPPTTRPGSLDLPSPVSLSEFGMMFPVLGPRSECSGASSPECEVERGDRAEGAETKTGDKANKNRSSSSSHSAEGLALDNRMKQLSLQCMKIKEGLSAGRKAAQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRN6</accession>
    <name>A0A151MRN6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0011157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005250">
        <property type="protein sequence ID" value="KYO27196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRN6"/>
    <dbReference type="STRING" id="8496.A0A151MRN6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="4">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO27196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="151" mass="16218" checksum="7B50F1C2012E1571" modified="2016-06-08" version="1">MASETSMPAPICLIENDPTDGLLVNQEALAQLQAGSQPVVVVAISGLYRIGKSCLMNRLAGRRTGFSTTQSHTKGIWMWCLPHPRRPDHMLVLLDTEGLGDVAKVSEGNTKNDSWILRCLCCSPAPWCTTACARPTSVPWTSRSILGPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRX9</accession>
    <name>A0A151MRX9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005226">
        <property type="protein sequence ID" value="KYO27284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRX9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="12151" checksum="40041C86A46A4F37" modified="2016-06-08" version="1">MNCDSFLTMDANENLHFCTTFHADVQKYVTKQTSAHKRDLEGEANSAKQSSTFKTGERGEDVASMATPYVDIPLGNNNLMELRGVQTTWRKLSSETLKGPVKCFPMETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSH2</accession>
    <name>A0A151MSH2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="19">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">AGPAT1</name>
        <name evidence="22" type="ORF">Y1Q_0020331</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37603"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:75121"/>
            <dbReference type="ChEBI" id="CHEBI:75122"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:37604"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74581"/>
            <dbReference type="ChEBI" id="CHEBI:74582"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37139"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74549"/>
            <dbReference type="ChEBI" id="CHEBI:74550"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:37140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37131"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:37132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37159"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74563"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:37160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37143"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74551"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:37144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37171"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74579"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:37172"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-eicosanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37183"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74583"/>
            <dbReference type="ChEBI" id="CHEBI:74584"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:37184"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:33187"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:64839"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-tetradecanoyl-sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37187"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:72683"/>
            <dbReference type="ChEBI" id="CHEBI:74586"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:37188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:19710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37155"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:74307"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74558"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:37156"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pentadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37175"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:74309"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74578"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:37176"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="19">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03005177">
        <property type="protein sequence ID" value="KYO27389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSH2"/>
    <dbReference type="STRING" id="8496.A0A151MSH2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF65">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 22" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="21">
        <location>
            <begin position="93"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO27389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="248" mass="27930" checksum="70A56C851704504A" modified="2016-06-08" version="1">MEVSAGVWALVLVLALVPLLYELSGSFRFVVKMAFYNGWILLLAAFALPLCAVRGRSVENMKILRSMLQHVKHLYGIRMDVRGLEHFDLKEPYVVVSNHQSSLDLLGMMEVLPDRCVPIAKRELLYMGTVGLACWLGGIIFINRQKTDDAISVMAEAARTMLREDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPVVPIVISSYQDFYNKKEWRFTSGESWLGGEVHGHVGRGLWGAWAIWGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSZ2</accession>
    <name>A0A151MSZ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="6">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">E2K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">DLST</name>
        <name evidence="21" type="ORF">Y1Q_0005183</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSZ2"/>
    <dbReference type="STRING" id="8496.A0A151MSZ2"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000033">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="20">
        <location>
            <begin position="70"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO27609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="423" mass="45964" checksum="3853F7F450FAE0BF" modified="2016-06-08" version="1">MLPLLSRSRCLSRALNALRQGNCTLARCSLSGVPRGQGLACANSRKFVANNSSIFAVRYFRTTAACRNDVVTVNTPAFAESVTEGDVRWEKAVGDTVTEDEVVCEIETDKTSVQVPAPAAGVIEALLVPDGGKVEGGTPLFKLRKTGAPIPTAMPPVPPVSTQPIESKPVSSVKPTAAPAVEPGPSKGARSEHRVKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHRDSFLKKHNMKLGFMSAFVKATAFALQDQPVVNAVIDDTTKEIVYRDYVDISVAVATPRGLVVPVIRNVETMNFADIERTINELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHAIVDRPVAVGGKVEVRPMMFVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSZ6</accession>
    <name>A0A151MSZ6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Disks large-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DLG5</name>
        <name evidence="8" type="ORF">Y1Q_0005199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MSZ6"/>
    <dbReference type="eggNOG" id="KOG0708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PDZ1_DLG5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06765">
        <property type="entry name" value="PDZ2_DLG5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06767">
        <property type="entry name" value="PDZ3_DLG5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06766">
        <property type="entry name" value="PDZ4_DLG5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11860">
        <property type="entry name" value="SH3_DLG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000130">
        <property type="entry name" value="Discs large 5, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000152">
        <property type="entry name" value="disks large homolog 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006907">
        <property type="entry name" value="DLG5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035537">
        <property type="entry name" value="DLG5_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053004">
        <property type="entry name" value="MAGUK_Signaling_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46360">
        <property type="entry name" value="DISKS LARGE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46360:SF1">
        <property type="entry name" value="DISKS LARGE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16610">
        <property type="entry name" value="dbPDZ_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04822">
        <property type="entry name" value="Takusan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="681"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="766"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="1396"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="1555"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1647"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="6">
        <location>
            <begin position="1829"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1138"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1274"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1321"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1480"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="129"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="423"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <end position="1343"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO27631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1973" mass="222029" checksum="0A04393F6356E168" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUN5</accession>
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        <submittedName>
            <fullName evidence="11">Free fatty acid receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0005149</name>
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    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
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            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070542">
        <property type="term" value="P:response to fatty acid"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013312">
        <property type="entry name" value="GPR40-rel_orph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45822:SF4">
        <property type="entry name" value="FREE FATTY ACID RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45822">
        <property type="entry name" value="FREE FATTY ACID RECEPTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01904">
        <property type="entry name" value="GPR40FAMILY"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO28243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="285" mass="29479" checksum="AC5A40C713B45868" modified="2016-06-08" version="1">MPTPDWLGLCVNAGAAALGLPAAGAALFHLARLPPSPSRIYRLHLLLADLALGLCLPLRALEAAWPGWAPPGPLCPLATLGHLGSLYAAACFSAALSAGRCLGAVYPLLYRRYRQPRYSCFICGGLWGVVGAHGLALVALETPSTSNGTLASVCPSVPRLGLRLELSMLLYFMPLVLAAFCTAGCLQALARSRLGWRRKLRAARVALASLALLLVASGPHNVAHVVGFAQGQDVAWHHLALLPAAATAVLDPLLGLAAEGRGARSCSGGGLSVVFHPRAGCIRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV33</accession>
    <name>A0A151MV33_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV33"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7203" checksum="6AA681C76B6574B5" modified="2016-06-08" version="1">MATMTLTMREWTPLTMHTTSPAGQQPTIPEQSSSVIPISSPSGTNWTWEEGQHLDVGEGCRGLQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVJ2</accession>
    <name>A0A151MVJ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0011403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004884">
        <property type="protein sequence ID" value="KYO28573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVJ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="3">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO28573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="250" mass="28016" checksum="B6C8207448CF2ECA" modified="2016-06-08" version="1">MQPPSEAELPSETTQPGPGDDFPTPETWCQRFRSFPYQEAEGAQEICQHCLEPQHHSKEQILVVLEQILAILPQEMQSLEWESGVETCAEEFQLEQAEDNKLQVTVNMKVAEVSSDEMQPTGALQGPVDSWLEQPRAHPVDRPLEEERERETPGHQDKPCYVPKDEALPHQESGAGTLSRTDQHPPEEGPINLELQQTLPGRWGERGSLPPESSQLQKGQCQPPKQRKSLEVSRAPAPVRSSWPSEVPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVV0</accession>
    <name>A0A151MVV0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0013907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004844">
        <property type="protein sequence ID" value="KYO28617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVV0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO28617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="134" mass="13830" checksum="43BC185B4AB2F932" modified="2016-06-08" version="1">MALGTTFDPATFELAKGLLTVSAILSFVAVSSILTSCCRLPRFKVGAVANTLTGLIGLSGLAMLGVTVSPLPNTFHPSVRPQLDWSFFAALTGSLAQLLSGLFCLITYLSSPQTPLTTDSTAGPDATPWPGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MW55</accession>
    <name>A0A151MW55_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Disintegrin and metalloproteinase domain-containing protein 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ADAM32</name>
        <name evidence="14" type="ORF">Y1Q_0018093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004780">
        <property type="protein sequence ID" value="KYO28732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MW55"/>
    <dbReference type="STRING" id="8496.A0A151MW55"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF158">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013153403" evidence="10">
        <location>
            <begin position="16"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="13">
        <location>
            <begin position="189"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="12">
        <location>
            <begin position="394"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="342"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO28732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="736" mass="80667" checksum="706D724750B8BFC0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MW69</accession>
    <name>A0A151MW69_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004772">
        <property type="protein sequence ID" value="KYO28750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MW69"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="190" mass="23206" checksum="65BB0E86A28542DC" modified="2016-06-08" version="1">MEAEHSLLEDEQTRHSYREHYAGWKTLWNLYQNQTEWRASVKERTRGFFQQPGKWQALFHWKWHEHLIRKLQNLHRLKKSKEEFMMCLRYRGGVEHWSKDSMLATAATFYLELCAEKPIDLESMKLCLRSLTRTFREDKQWQLDEDWMPEELKRTLQSFKNSKTPVLDGLPKEFYLTFWDLMGPDLLELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWB1</accession>
    <name>A0A151MWB1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004757">
        <property type="protein sequence ID" value="KYO28775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWB1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31574" checksum="3A023B43A2B5FB29" modified="2016-06-08" version="1">MGASCQAGRGTRGKGQAPAVPLADSDDYEIQLGTAEQAPDGKSFQQETRLIFTPSVQRDQGAQYICRVQHVALEQPVEKSSAELQVTGLPWPVEEPQISESEPKDETDEPQRREETEPEQKPSLNSSGPQKPRGPLPPLEVPDISRNHFTSSRPKDETDEPQRREETELEQKPSLNSSGPQQPRGPLPPLEVPDISRNRFTSLRHKDETDEPQRREETEPEQKPSLNSSGPQQPRDLLQPPKMPGTSGRVTSLRQISSELGDRCPRSTCCPTHTTRRKCSLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A151MWN0_ALLMI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWN0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="8374" checksum="03FF3743BA8CE06F" modified="2016-06-08" version="1">MSSIQVVYRKVVELSRISVLVSKLMKVSAWKKESIRKKQCSVWDFGLVCLLLKIKYRINSEGLYSVHAWGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N179</accession>
    <name>A0A151N179_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N179"/>
    <dbReference type="STRING" id="8496.A0A151N179"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7601" checksum="94AEF1449DB93031" modified="2016-06-08" version="1">MATYVAEELLKWRSPVIPVAKPNGLLFLCINFQKLNTLATFDTFPMPHITHLIEKIGEARLMHLAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1B5</accession>
    <name>A0A151N1B5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004164">
        <property type="protein sequence ID" value="KYO30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1B5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="94" mass="10480" checksum="E5E47A1365756ECB" modified="2016-06-08" version="1">MNGLSLFLTPRGAFGKYVLTAELTQVKGIWDWTPELSCLQSEPPHHKAKPELLHPQWCCTLARMLVGLLGALPMLLCATGRFRNLLSALVYELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1F2</accession>
    <name>A0A151N1F2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Palmitoleoyl-protein carboxylesterase notum2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0008226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pectinacetylesterase family. Notum subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1F2"/>
    <dbReference type="STRING" id="8496.A0A151N1F2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990699">
        <property type="term" value="F:palmitoleyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004963">
        <property type="entry name" value="PAE/NOTUM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562:SF10">
        <property type="entry name" value="CARBOXYLESTERASE NOTUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562">
        <property type="entry name" value="NOTUM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03283">
        <property type="entry name" value="PAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585647" description="Palmitoleoyl-protein carboxylesterase notum2" evidence="3">
        <location>
            <begin position="34"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO30582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54797" checksum="5BDDECA9CBBCB1DB" modified="2016-06-08" version="1">MPRASLPRLVEEVFTMKISGALLALLLLGEAVSQSKRQSKANVKTPAQSRKGLNSAGELAQTATEEDTFVGVLPPVRDALALQLRSPSLAPLPALKALNNMKLFFLRNSGVTCNDGTAAGYYLRESRGSKRWIIFLEGGWCCYNKETCDTRYKNIRRLMSSSDWPQTKKGTGILSAQMEESPHWWNANAVFVPYCSSDIWSGTLPKSRQDYAFMGSLIIQEVIKDLVPKGIKHAKVVLLAGASAGGTGVLLNLERVAALLEELEAEAVQVRGLVDSGWFLDINHPRQSDCSDAASQSSTDAIKKGLRMWNGILPEKCRQRFKKADEWQCFLGYRLFSSLKSPVFVVQWLFDEEQMKLENIHLSGQSLEENQWNYIQNLGRELRNSLRDVPAVFAPACLSHTLITKSYWMEFQVKEKLYPVKGKYEPFDDAVQGPQNLECHRELMSKQRGSLFSSTSPNNSTWGYWVSGPSGKMLFKHTLATLKDASTRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1K6</accession>
    <name>A0A151N1K6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">USP42</name>
        <name evidence="10" type="ORF">Y1Q_0008270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1K6"/>
    <dbReference type="STRING" id="8496.A0A151N1K6"/>
    <dbReference type="eggNOG" id="KOG1865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000016">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF727">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="80"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="707"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO30640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="839" mass="92183" checksum="7ADBA3DE079C152C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1L4</accession>
    <name>A0A151N1L4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRCA1-associated ATM activator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BRAT1</name>
        <name evidence="4" type="ORF">Y1Q_0008331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260700.2">
        <property type="nucleotide sequence ID" value="XM_006260638.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1L4"/>
    <dbReference type="STRING" id="8496.A0A151N1L4"/>
    <dbReference type="GeneID" id="102560452"/>
    <dbReference type="KEGG" id="amj:102560452"/>
    <dbReference type="CTD" id="221927"/>
    <dbReference type="eggNOG" id="ENOG502QRW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057956at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038904">
        <property type="entry name" value="BRAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21331:SF2">
        <property type="entry name" value="BRCA1-ASSOCIATED ATM ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO30716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="837" mass="91796" checksum="1D8DA16EDD6DF565" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2B2</accession>
    <name>A0A151N2B2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004131">
        <property type="protein sequence ID" value="KYO30902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2B2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="83" mass="8304" checksum="A6CBAD7F1D43CE41" modified="2016-06-08" version="1">MPRGQKREPGPVNSHAGAGQSWRSEPRAGAGPELGASGAGAGGGYKAPPFASQGGRGGRSPLLRCRDSANMSNGRSSSQDLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3K3</accession>
    <name>A0A151N3K3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inositol 2-dehydrogenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0006002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3K3"/>
    <dbReference type="STRING" id="8496.A0A151N3K3"/>
    <dbReference type="KEGG" id="amj:102559803"/>
    <dbReference type="eggNOG" id="KOG2741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N3K3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="225"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="358"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO31403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="567" mass="61512" checksum="DC9673F41BCF629E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4S2</accession>
    <name>A0A151N4S2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP-1 complex subunit beta-1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AP1B1</name>
        <name evidence="11" type="ORF">Y1Q_0022859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4S2"/>
    <dbReference type="STRING" id="8496.A0A151N4S2"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000003">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585743" evidence="8">
        <location>
            <begin position="17"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="737"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="10">
        <location>
            <begin position="856"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="970" mass="106449" checksum="10138D5A5A0FE42D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6M3</accession>
    <name>A0A151N6M3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CORO7</name>
        <name evidence="12" type="ORF">Y1Q_0020348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6M3"/>
    <dbReference type="STRING" id="8496.A0A151N6M3"/>
    <dbReference type="eggNOG" id="KOG1445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000076">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="228"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO32387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="687" mass="75277" checksum="169B6C3B07B2E186" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N747</accession>
    <name>A0A151N747_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Wilms tumor protein 1-interacting protein isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WTIP</name>
        <name evidence="10" type="ORF">Y1Q_0007808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zyxin/ajuba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003905">
        <property type="protein sequence ID" value="KYO32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N747"/>
    <dbReference type="STRING" id="8496.A0A151N747"/>
    <dbReference type="eggNOG" id="KOG1701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09352">
        <property type="entry name" value="LIM1_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09355">
        <property type="entry name" value="LIM2_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09438">
        <property type="entry name" value="LIM3_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000028">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000036">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000037">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047245">
        <property type="entry name" value="Ajuba-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047247">
        <property type="entry name" value="Ajuba-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047248">
        <property type="entry name" value="Ajuba-like_LIM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF6">
        <property type="entry name" value="WILMS TUMOR PROTEIN 1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="263"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="328"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="389"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO32628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="474" mass="51168" checksum="4E5DD3BA02E08AB3" modified="2016-06-08" version="1">MQDLSLHEAGGEEPRRGRRGEEPGARSEVALPCYGGKRYEPAKYRSPRASLADKRGSPRASLAAPGPERYPSPRASLGPLDLSPRSSYASTAGDASKHSSPRASLAGSDGSKPSSNRTSGISLGYDQRRASTASQHSGCSDCRPGAADLPAAALGSPRSSISSHSSRGSLGAYPELQLPSPRASLLGPDEAGEPPPGLLLPSYACSPGKGSSAAAAAAPRFKLPFQVTPSRESGPSQAERRLEALTLELEKELEMHMKKEYFGICIKCGKGVYGASQACQAMGNLYHTNCFTCCSCGRRLRGKAFYNVNGKVYCEEDFLYSGFQQTADKCFVCGHLIMEMILQALGKSYHPGCFRCVVCNECLDGVPFTVDVENNIYCVKDYHTVFAPKCASCNQPILPAQGSEETIRVVSMDKDYHVECYHCEDCGLQLNDEEGHRCYPLEGHLLCHGCHIRRLNIKVPPHPPPSYPMHVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7M4</accession>
    <name>A0A151N7M4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7M4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7935" checksum="1406AC7A86032C21" modified="2016-06-08" version="1">MATGNRTWVSPTRVLDPVLRLHSAARKRSSMSSAVRNTNSLTYESIFFQKLLKAWSPDPDCTLKHTPTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8V7</accession>
    <name>A0A151N8V7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tribbles homolog 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRIB2</name>
        <name evidence="10" type="ORF">Y1Q_0011329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003826">
        <property type="protein sequence ID" value="KYO33019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260919.1">
        <property type="nucleotide sequence ID" value="XM_006260857.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8V7"/>
    <dbReference type="STRING" id="8496.A0A151N8V7"/>
    <dbReference type="GeneID" id="102576433"/>
    <dbReference type="KEGG" id="amj:102576433"/>
    <dbReference type="CTD" id="28951"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14022">
        <property type="entry name" value="PK_TRB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000153">
        <property type="entry name" value="Tribbles homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000253">
        <property type="entry name" value="tribbles homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF15">
        <property type="entry name" value="TRIBBLES HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="61"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO33019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="343" mass="38772" checksum="B6E8FBDAEE832290" modified="2016-06-08" version="1">MNIQRSTPISIARYGRPRSKTQDLEELSSLRSVEPSQSFSPNLGSPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDIGCYQELLAPCFCLPAHKNINQITEIILGETKAYVFFERSYGDMHSFVRTCKKLKEEEAAKLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEDRTRVKLESLEDAYILRGNDDSLSDKHGCPAYVSPEILNTNGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFNVSNSGYGAKEVSDQLVPDVNMEEDLDPFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N998</accession>
    <name>A0A151N998_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-associated and pleckstrin-like proteiny domains-containing protein 1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RAPH1</name>
        <name evidence="11" type="ORF">Y1Q_0008631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MRL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N998"/>
    <dbReference type="STRING" id="8496.A0A151N998"/>
    <dbReference type="eggNOG" id="KOG3751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16136">
        <property type="entry name" value="RA_MRL_Lpd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000048">
        <property type="entry name" value="Ras association (RalGDS/AF-6) and pleckstrin homology domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000027">
        <property type="entry name" value="Ras association (RalGDS/AF-6) and pleckstrin homology domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF15">
        <property type="entry name" value="RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="10">
        <location>
            <begin position="305"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="432"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="636"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="762"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="879"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="648"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="771"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="944"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO33408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="956" mass="105010" checksum="263A3A6C5F6F0298" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9K7</accession>
    <name>A0A151N9K7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclic AMP-responsive element-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CREB1</name>
        <name evidence="10" type="ORF">Y1Q_0008652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266001.1">
        <property type="nucleotide sequence ID" value="XM_006265939.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266002.1">
        <property type="nucleotide sequence ID" value="XM_006265940.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449697.1">
        <property type="nucleotide sequence ID" value="XM_014594211.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019347720.1">
        <property type="nucleotide sequence ID" value="XM_019492175.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019347721.1">
        <property type="nucleotide sequence ID" value="XM_019492176.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9K7"/>
    <dbReference type="STRING" id="8496.A0A151N9K7"/>
    <dbReference type="GeneID" id="102564978"/>
    <dbReference type="KEGG" id="amj:102564978"/>
    <dbReference type="CTD" id="1385"/>
    <dbReference type="eggNOG" id="KOG3584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970722at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N9K7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990589">
        <property type="term" value="C:ATF4-CREB1 transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035497">
        <property type="term" value="F:cAMP response element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000003">
        <property type="entry name" value="cAMP-responsive element modulator isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003102">
        <property type="entry name" value="CREB1-like_pKID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001630">
        <property type="entry name" value="Leuzip_CREB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879:SF1">
        <property type="entry name" value="CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02173">
        <property type="entry name" value="pKID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00041">
        <property type="entry name" value="LEUZIPPRCREB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50953">
        <property type="entry name" value="KID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="KID" evidence="9">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="269"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="327" mass="35123" checksum="AA51413B87CFA86C" modified="2016-06-08" version="1">MTMESGAENQQSGDAAVTEAETQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9N5</accession>
    <name>A0A151N9N5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9N5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="8919" checksum="B21182202E35CEED" modified="2016-06-08" version="1">MSKFVAMRKVSSLIQKKGKVSEMKLPNDILFARHHFKDMQEDEIECSKGNINPMNSFEDILCAIFQNVSSKIHPCCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBU7</accession>
    <name>A0A151NBU7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0023700</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03003562">
        <property type="protein sequence ID" value="KYO34257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NBU7"/>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000032">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF435">
        <property type="entry name" value="PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1041"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1082"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1120"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1153"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="172"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1268"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1284"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO34257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1293" mass="142669" checksum="95BBEA50677AF4B2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ND94</accession>
    <name>A0A151ND94_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">DNA polymerase</fullName>
            <ecNumber evidence="26">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">POLB</name>
        <name evidence="29" type="ORF">Y1Q_0024431</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="function">
        <text evidence="23">Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76255"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:18657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:195194"/>
            <dbReference type="ChEBI" id="CHEBI:195195"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 26">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 26">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="26"/>
    <dbReference type="EMBL" id="AKHW03003351">
        <property type="protein sequence ID" value="KYO34710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273589.1">
        <property type="nucleotide sequence ID" value="XM_006273527.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ND94"/>
    <dbReference type="STRING" id="8496.A0A151ND94"/>
    <dbReference type="GeneID" id="102561879"/>
    <dbReference type="KEGG" id="amj:102561879"/>
    <dbReference type="CTD" id="5423"/>
    <dbReference type="eggNOG" id="KOG2534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="PhylomeDB" id="A0A151ND94"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051575">
        <property type="term" value="F:5'-deoxyribose-5-phosphate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000002">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000002">
        <property type="entry name" value="DNA polymerase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000026">
        <property type="entry name" value="DNA polymerase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000021">
        <property type="entry name" value="DNA polymerase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF42">
        <property type="entry name" value="DNA POLYMERASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 26" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18 26" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15 26" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 26" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20 26" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 26" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="28">
        <location>
            <begin position="10"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="27">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="27">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="25">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KYO34710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="335" mass="38352" checksum="F838DEB02F0078E8" modified="2016-06-08" version="1">MSKRKAPREGPNEGITDFLTELANYERNVSRAVHKYNAYRKAASAIAKYPSKIRSGAEAKKLEGVGAKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPAAARKFVDEGIKTLEDLRKNEHKLNHHQRIGLKYFEDFEKRIPREEMLQMQEIVLIEVKKLDPRYIATVCGSFRRGAESSGDMDILLTHPDFTSESAKQPKLLHQVVEQLEKVHFITDTLSKGDTKFMGVCQLPNEEDGTTYPYRRIDIRLIPKDQYFCGVLYFTGSDIFNKNMRTRALEMGFTINEYTIRPLGVTGIAGEALPVDSEEDIFDYIQWKYREPKDRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDC4</accession>
    <name>A0A151NDC4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0010541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003332">
        <property type="protein sequence ID" value="KYO34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDC4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001872">
        <property type="term" value="F:(1-&gt;3)-beta-D-glucan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071226">
        <property type="term" value="P:cellular response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03593">
        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042808">
        <property type="entry name" value="CLEC7A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033992">
        <property type="entry name" value="NKR-like_CTLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="155"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="378" mass="42092" checksum="CC91854F6B2E7073" modified="2016-06-08" version="1">MSVFVAPLDMSEHIITYSDLKFGPSKRQKHEDKVRQKEMSTYSELKFQNQAEQQRGRRFQEAGSRGAGGSPNPSRRNKGPPCRRQCATVILGILCLVLLIATGVLSYLVTKLSQGKGINSELLTSCSGQQPGLPEIPDEQPGDTGQKCPARWATAEGSSYLFSPQKGTWEYCKSSCKSQSAQQLSIGNRNELDFIKQELYQYYEDRKGVLWYYPFWIGLSYDPGSRKWVWEDNTALSSGLFDLQDLSHQNDLGRVCAYIQAQRSPSTAPELCRKSKAPLSMSNYMVTYPDLKLDPSKRQKHEGKVSPRASSSWLPLALALGAQMLCLLLMIGLRIYDGQVSELGRELGREKGKNTQLLTSCQGQKPGFSGTEPRGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDL4</accession>
    <name>A0A151NDL4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003364">
        <property type="protein sequence ID" value="KYO34625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDL4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="202" mass="22398" checksum="8E4881B5D8ED39FA" modified="2016-06-08" version="1">MQTFTSVRSHVGKPMSCQPIIEFSSRPTGKDQTAVLGGSSKDCIALEDGQITITTRWLHIHCSAALLHAELLDNWDKELAAPLPSLLGAPPGRCLKAIPPPCCHCTPIMSLLHLLQAVHDKLFVQVERYPSHYTLLLLSLLVSHAHLHSWFRILSYDGVGDKPSLPCNLHCHLESFLSQQYMSLPLTAKEEIATRIDTFLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NE61</accession>
    <name>A0A151NE61_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PH and SEC7 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0000987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NE61"/>
    <dbReference type="STRING" id="8496.A0A151NE61"/>
    <dbReference type="KEGG" id="amj:102572462"/>
    <dbReference type="eggNOG" id="KOG0932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13295">
        <property type="entry name" value="PH_EFA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000004">
        <property type="entry name" value="PH and SEC7 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000054">
        <property type="entry name" value="PH and SEC7 domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF337">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="9">
        <location>
            <begin position="549"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="792"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117870" checksum="8B2D5FCFF799C0EC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NF24</accession>
    <name>A0A151NF24_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NF24"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="160" mass="17782" checksum="55DEC673F1557E3F" modified="2016-06-08" version="1">MPFWKTGYLRIGLACSHTGLMKQFVASEGPMTIQALCMVDPNPQTNHDFFRSIERSWFLRMPTFPFHYLQSVILYKGPCGIGPPEHKAFGAALRGPQGGSHLCYSARNECAFIASTWSRSRTNASETVVGAVLYQEQEGMERPVAISGKKSNAAEKRHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFU7</accession>
    <name>A0A151NFU7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0017675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03003127">
        <property type="protein sequence ID" value="KYO35668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFU7"/>
    <dbReference type="STRING" id="8496.A0A151NFU7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022162">
        <property type="entry name" value="TRPC4AP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743:SF1">
        <property type="entry name" value="SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN TCPC4AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12463">
        <property type="entry name" value="DUF3689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO35668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="882" mass="101645" checksum="86120C3CF928AD2F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGJ2</accession>
    <name>A0A151NGJ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein polybromo-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PBRM1</name>
        <name evidence="16" type="ORF">Y1Q_0007589</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003049">
        <property type="protein sequence ID" value="KYO35908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NGJ2"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05524">
        <property type="entry name" value="Bromo_polybromo_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05517">
        <property type="entry name" value="Bromo_polybromo_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05520">
        <property type="entry name" value="Bromo_polybromo_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05518">
        <property type="entry name" value="Bromo_polybromo_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05515">
        <property type="entry name" value="Bromo_polybromo_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05526">
        <property type="entry name" value="Bromo_polybromo_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21984">
        <property type="entry name" value="HMG-box_PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000009">
        <property type="entry name" value="Protein polybromo-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000011">
        <property type="entry name" value="Protein polybromo-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000013">
        <property type="entry name" value="Protein polybromo-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000006">
        <property type="entry name" value="protein polybromo-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000010">
        <property type="entry name" value="protein polybromo-1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000015">
        <property type="entry name" value="protein polybromo-1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000003">
        <property type="entry name" value="protein polybromo-1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037968">
        <property type="entry name" value="PBRM1_BD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="201"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="403"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="541"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="679"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="820"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="15">
        <location>
            <begin position="959"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="15">
        <location>
            <begin position="1114"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="1337"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="1337"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="489"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="905"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1279"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1313"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1451"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="905"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1279"/>
            <end position="1294"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO35908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1589" mass="182193" checksum="C1FC25EA245EA3A8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHP5</accession>
    <name>A0A151NHP5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Engulfment and cell motility protein 3 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ELMO3</name>
        <name evidence="11" type="ORF">Y1Q_0021974</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KYO36179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="8496.A0A151NHP5"/>
    <dbReference type="KEGG" id="amj:102563284"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PH_ELMO1_CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Engulfment and cell motility 1 (Ced-12 homolog)"/>
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    </dbReference>
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        <property type="entry name" value="Engulfment and cell motility protein 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF8">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="10">
        <location>
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            <end position="497"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO36179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="673" mass="77133" checksum="E8D9DCE6723D7C30" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJC9</accession>
    <name>A0A151NJC9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterile alpha motif domain-containing protein 13 isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SAMD13</name>
        <name evidence="2" type="ORF">Y1Q_0020838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059583980.1">
        <property type="nucleotide sequence ID" value="XM_059727997.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059583981.1">
        <property type="nucleotide sequence ID" value="XM_059727998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJC9"/>
    <dbReference type="STRING" id="8496.A0A151NJC9"/>
    <dbReference type="GeneID" id="132250756"/>
    <dbReference type="CTD" id="148418"/>
    <dbReference type="eggNOG" id="ENOG502RZ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NJC9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09583">
        <property type="entry name" value="SAM_Atherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF139">
        <property type="entry name" value="ATHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="59"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="130" mass="14552" checksum="EAF70F647C190132" modified="2016-06-08" version="1">MGNSGNKLDFLQIHCVYVSEVKETSVLPMLSVDMENKENGSLDVKNSVENGRPPDPADWAVTDVVNYFRTAGFEEQAIAFQEQEIDGKSLLLMTRNDVLTGLSLKLGPALKIYEYHIKPLQTQHLKNNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJW3</accession>
    <name>A0A151NJW3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fanconi anemia core complex-associated protein 100 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FAAP100</name>
        <name evidence="1" type="ORF">Y1Q_0015281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002865">
        <property type="protein sequence ID" value="KYO37093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019344464.1">
        <property type="nucleotide sequence ID" value="XM_019488919.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059587973.1">
        <property type="nucleotide sequence ID" value="XM_059731990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJW3"/>
    <dbReference type="STRING" id="8496.A0A151NJW3"/>
    <dbReference type="GeneID" id="102565223"/>
    <dbReference type="KEGG" id="amj:102565223"/>
    <dbReference type="CTD" id="80233"/>
    <dbReference type="eggNOG" id="ENOG502QTI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6495021at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029251">
        <property type="entry name" value="Faap100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14890">
        <property type="entry name" value="FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14890:SF1">
        <property type="entry name" value="FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15146">
        <property type="entry name" value="FANCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="870" mass="91637" checksum="B377B585D46B2BBC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKC0</accession>
    <name>A0A151NKC0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C-type lectin domain family 14 member A isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CLEC14A</name>
        <name evidence="11" type="ORF">Y1Q_0008934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002792">
        <property type="protein sequence ID" value="KYO37232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261274.2">
        <property type="nucleotide sequence ID" value="XM_006261212.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKC0"/>
    <dbReference type="GeneID" id="102563240"/>
    <dbReference type="KEGG" id="amj:102563240"/>
    <dbReference type="CTD" id="161198"/>
    <dbReference type="eggNOG" id="ENOG502S0KN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9890094at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990430">
        <property type="term" value="F:extracellular matrix protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051505">
        <property type="entry name" value="C-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789:SF5">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 14 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789">
        <property type="entry name" value="CHONDROLECTIN VARIANT CHODLFDELTAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586130" evidence="9">
        <location>
            <begin position="21"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO37232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="435" mass="47069" checksum="7B99FA2EC4592D36" modified="2016-06-08" version="1">MSGVIPLCLLLQAIYMLCNGAGQSLSSHTWCSKTGTCYSIHGATLAFHQAWDECAQHRGTLTQVRNTAELRDILALLNMVTAGSGALLFWVGLIRKQQECTHPERPLRGFSWQTRPQQDLKEEPSELDKWVKEPSSSCTTSRCAALQVTAGQPSMESWGWKEQRCNKTTQGFICKYQYNGTCPILHPQKPLSFIYQFPDNLPRASKGSSPPGTVLNVTCPSPQGVVQLVCQLGQDGYTWTAAEKPFCFCPSGYLNSSTRNCVDPHDCFSAQGTFLCMCAQGFQLGKDAKSCTQDPRGLTTAVPDLTFSSLPTLAQGSLNVPSTNSPAHTSAAVEMFSSSSNYVFILVTIAVVVLVILVMTTLGVFKLCFNKTPSSSGQDGREPAAVAESDPEGTTTQSNSEHSLEAAAKGNQPGGDRAETLQGEHVPEDRAPQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NM40</accession>
    <name>A0A151NM40_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002566">
        <property type="protein sequence ID" value="KYO37858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NM40"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9182" checksum="AE68CB7039D7F942" modified="2016-06-08" version="1">MLLSTTQTVLVSPGGMNGGVFAMQDEMSAGKYLVTKMECAWHHPQLDVIGKGGCRYDSEGDLEESLQHVKKCLHVHGSWCEANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NN78</accession>
    <name>A0A151NN78_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM164</name>
        <name evidence="2" type="ORF">Y1Q_0015549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019343354.1">
        <property type="nucleotide sequence ID" value="XM_019487809.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NN78"/>
    <dbReference type="STRING" id="8496.A0A151NN78"/>
    <dbReference type="GeneID" id="102564114"/>
    <dbReference type="KEGG" id="amj:102564114"/>
    <dbReference type="CTD" id="84187"/>
    <dbReference type="eggNOG" id="ENOG502QWAJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17328at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NN78"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14808">
        <property type="entry name" value="TMEM164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="296" mass="33509" checksum="CAED338AC2DCD167" modified="2016-06-08" version="1">MWRPAMARYSLGAALDWLYGGVDPSFEGNGGPECAAFLSGRQRLLESLVFLSLGVAEALLALRRIRRLPGREEEEERLLQRAPAPHESLGKNLVLVALALTFGVEVGFKFATRTVIYLLNPCHVVTMMQIFLLACPPCRLAMVLFRLQMHMLNGALLALLFPVVNTRLLPFEMEIYYIQHVMLYVVPIYLLRKGGIYTPEPLSNFWWALLSTGLMFVYHFSILQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTIMTMAHGKLVILLFHSAVPIFKYSVDLLRLPAKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP36</accession>
    <name>A0A151NP36_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP36"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9735" checksum="C3230C621C85C65B" modified="2016-06-08" version="1">MKESQITSQYADGYRKWVILVSKAFKSSIEARRKYKRLQKRSRKSRRAVLPSAVTLQLPTKSTGLPLFSDLVTEKTRYEMLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQG4</accession>
    <name>A0A151NQG4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FERM domain-containing protein 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FRMD4B</name>
        <name evidence="12" type="ORF">Y1Q_0023429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQG4"/>
    <dbReference type="STRING" id="8496.A0A151NQG4"/>
    <dbReference type="eggNOG" id="KOG3529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13191">
        <property type="entry name" value="FERM_C_FRMD4A_FRMD4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17200">
        <property type="entry name" value="FERM_F1_FRMD4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000008">
        <property type="entry name" value="FERM domain containing 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000019">
        <property type="entry name" value="FERM domain containing 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000022">
        <property type="entry name" value="Putative FERM domain-containing protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041785">
        <property type="entry name" value="FRMD4A/B_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF3">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="617"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="698"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="885"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="924"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="965"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="975"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO38735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116560" checksum="5ADD77C9221DE846" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQQ1</accession>
    <name>A0A151NQQ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002379">
        <property type="protein sequence ID" value="KYO39108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQQ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="8097" checksum="53A5228BDCFAEA6B" modified="2016-06-08" version="1">MQLVGQERTQAHTAWIQGTQRITGRGQSTRATQAPIQEDKPHGRPPPLTSVDLHVGTRAGWQMQNLSSLETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSS2</accession>
    <name>A0A151NSS2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="22">HMG-CoA synthase</shortName>
            <ecNumber evidence="22">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">HMGCS2</name>
        <name evidence="25" type="ORF">Y1Q_0006712</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:10189"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 22">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 22">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="22"/>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSS2"/>
    <dbReference type="STRING" id="8496.A0A151NSS2"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF1">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5 22" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 22" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 22" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17 22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 22" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16 22" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="23">
        <location>
            <begin position="53"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="24">
        <location>
            <begin position="228"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="20">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="20">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="20">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO39838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="502" mass="55662" checksum="D17C655A405BB2FD" modified="2016-06-08" version="1">MFRFFSRSKRYLQVKRVLQRQEQPSWPAHHVAAAQKGSFSTIPMDRSSRSDLWPKDVGIQALEVYFPSQYVEQVELEKYDGVEAGKYTQGLGQRQMGFCSAHEDINSLCLTVVQRLVERSHLSWDSIGRLEVGTETIIDKSKAVKTVLMQLFQDSGNTDVEGIDTTNACYGGTASLFNAADWVESSSWDGRYALVVCGDIAVYATGNARPTGGAGAVAMLVGPNAPLALERGLRGTHMENAYDFYKPDLASEYPVVDGKLSIQCYFRALDQCYAVYRKKIQSQWQKEGITKPFTMEDFQFIIFHTPFCKLVQKSVGRLLLNDFLAAPKPDTESGIYKGLQSFRGKKLEDTYSDKDVEKAFQKASLEIFSQKTKPSLLLSSRNGNMYTPSVYGCLASLLAQCSAQQLAGSRIGAFSYGSGLAASLFSLRVSQDAAPGSSLDKLVSSLSDLQTRLDSRKCIPPEEFAQIMKLREDTHHLANHTPHGSKDNLFPGTWTVQICATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU83</accession>
    <name>A0A151NU83_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Interleukin enhancer-binding factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0008988</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001975">
        <property type="protein sequence ID" value="KYO40303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NU83"/>
    <dbReference type="STRING" id="8496.A0A151NU83"/>
    <dbReference type="eggNOG" id="KOG3792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8898434at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19910">
        <property type="entry name" value="DSRM_ILF3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19912">
        <property type="entry name" value="DSRM_ILF3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000001">
        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000006">
        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000008">
        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033099">
        <property type="entry name" value="DSRM1_ILF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF4">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DZF" evidence="15">
        <location>
            <begin position="5"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="14">
        <location>
            <begin position="404"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="14">
        <location>
            <begin position="535"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="475"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="727"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="748"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="821"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO40303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="97167" checksum="5CEDBD1F66BB6A84" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUF6</accession>
    <name>A0A151NUF6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001930">
        <property type="protein sequence ID" value="KYO40373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUF6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="9914" checksum="ABFA77B80A81766B" modified="2016-06-08" version="1">MGRRLPTDVAGGVGGGGRWETAWIKGAGLSARTLGLSRLGPSLLGDLCNLWKSWSRILALFLTVQTCTRRVVLCPKASVTWSIKTYIRILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW08</accession>
    <name>A0A151NW08_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rho GTPase-activating protein 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Rho-type GTPase-activating protein 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0022333</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with NHERF1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001697">
        <property type="protein sequence ID" value="KYO41092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NW08"/>
    <dbReference type="STRING" id="8496.A0A151NW08"/>
    <dbReference type="KEGG" id="amj:106736790"/>
    <dbReference type="eggNOG" id="KOG4270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NW08"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07618">
        <property type="entry name" value="BAR_Rich1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04386">
        <property type="entry name" value="RhoGAP_nadrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000019">
        <property type="entry name" value="rho GTPase-activating protein 17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="BAR" evidence="17">
        <location>
            <begin position="14"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="16">
        <location>
            <begin position="253"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="513"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="773"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO41092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="887" mass="95925" checksum="038FE9FF885CB1BF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX08</accession>
    <name>A0A151NX08_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosducin-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PDCL3</name>
        <name evidence="17" type="ORF">Y1Q_0006234</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain). Forms ternary complexes with the chaperonin CCT complex and actin substrate, leading to inhibition of actin folding. Interacts with XIAP (via BIR 3 and RING domain). Interacts with HSP90AA1 and HSP90AB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014455882.1">
        <property type="nucleotide sequence ID" value="XM_014600396.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX08"/>
    <dbReference type="STRING" id="8496.A0A151NX08"/>
    <dbReference type="GeneID" id="102566158"/>
    <dbReference type="KEGG" id="amj:102566158"/>
    <dbReference type="CTD" id="79031"/>
    <dbReference type="eggNOG" id="KOG3170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NX08"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043184">
        <property type="term" value="F:vascular endothelial growth factor receptor 2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000081">
        <property type="entry name" value="phosducin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF4">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="16">
        <location>
            <begin position="34"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO41416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="241" mass="28004" checksum="224A539F3651589D" modified="2016-06-08" version="1">MQNPNEDTEWNDILRKKGILPPKEKLKEQEQAKEEEELRILQQQSIVKTYEDMTLEELEDNEDEFNEEDERAVEMYRQQRLAEWKATQMKNKFGELLEISGLDYVQEVTKAGKDIWVILHLYKQGIPLCALINQHLSGLAKKFPDVKFIKAISTTCIPNYPDRNLPTIFIYLEGDIKAQFIGPLVFGGMNLTRDELEWKISESGAIKTDLEENPRKQIQDQLMSSIKSSFSTKKDSDSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX58</accession>
    <name>A0A151NX58_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="28">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">Y1Q_0006169</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21 28">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="24">Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP11A and an accessory beta subunit TMEM30A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Membrane</location>
            <topology evidence="28">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 28">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="28"/>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX58"/>
    <dbReference type="STRING" id="8496.A0A151NX58"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010831">
        <property type="term" value="P:positive regulation of myotube differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000016">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000012">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF33">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 26 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="16 27 28" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 27" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 26 28" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17 28" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="1008"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="1042"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="1076"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="1106"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="30">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="29">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="31">
        <location>
            <begin position="894"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="25">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="732"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="841"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="847"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="868"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="871"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00065117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KYO41323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1204" mass="138136" checksum="43768E9EAADAC5E4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXQ1</accession>
    <name>A0A151NXQ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001657">
        <property type="protein sequence ID" value="KYO41205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXQ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="105" mass="10767" checksum="1A3CF587577E7379" modified="2016-06-08" version="1">MGRLSGQPRTAPSAPPRAGVDSSRCRRAGGARVGPLGRGGAEPAARAPGCYGESAREAPQLLIPDTSPRPPLPYCVGPGRTELACLPTHGRPIQLNGSSNWNDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZ04</accession>
    <name>A0A151NZ04_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Somatomedin-B and thrombospondin type-1 domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0002756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZ04"/>
    <dbReference type="STRING" id="8496.A0A151NZ04"/>
    <dbReference type="eggNOG" id="ENOG502QV8I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056801">
        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF4">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25031">
        <property type="entry name" value="SBSPON_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586499" evidence="4">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="5">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="SBSPON-like C-terminal" evidence="6">
        <location>
            <begin position="205"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="311" mass="34628" checksum="8660FE1588309500" modified="2016-06-08" version="1">MFFLESQTLLALELLPGVSGNARLCARGHEGPLKVKELPKQKLAHRLFYLGELESSPLLITCILAKQTETFCKSPREKTEAGKWLSGFPSLSVPELFSILTAHQNACGRSLDCCHDYPRACPVTPCTVSEWSDWSGCAEPCKATYRVRRRHVVQEQRNGGEACPPLEEKAGCVEYWTQQGVECNHALLPALITTGGYGKARRKRAASSENERAGYCVEFQLAAITEGCLHGNSSYTRWMRYLSEGHIACVECQHPALHSRSLHCYGDGSGSKKNQLLHWQAVGNPQCRGTWKRIRQLDTCSCPSVHSFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZK3</accession>
    <name>A0A151NZK3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disks large-associated protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DLGAP4</name>
        <name evidence="3" type="ORF">Y1Q_0002842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340201.1">
        <property type="nucleotide sequence ID" value="XM_019484656.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340202.1">
        <property type="nucleotide sequence ID" value="XM_019484657.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340203.1">
        <property type="nucleotide sequence ID" value="XM_019484658.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340204.1">
        <property type="nucleotide sequence ID" value="XM_019484659.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059589218.1">
        <property type="nucleotide sequence ID" value="XM_059733235.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059589219.1">
        <property type="nucleotide sequence ID" value="XM_059733236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZK3"/>
    <dbReference type="STRING" id="8496.A0A151NZK3"/>
    <dbReference type="GeneID" id="102558428"/>
    <dbReference type="CTD" id="22839"/>
    <dbReference type="eggNOG" id="KOG3971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10036956at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099572">
        <property type="term" value="C:postsynaptic specialization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF19">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO42228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="968" mass="108043" checksum="EBF73F3411022E39" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZT3</accession>
    <name>A0A151NZT3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM149B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM149B1</name>
        <name evidence="4" type="ORF">Y1Q_0022246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM149 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014464842.1">
        <property type="nucleotide sequence ID" value="XM_014609356.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZT3"/>
    <dbReference type="STRING" id="8496.A0A151NZT3"/>
    <dbReference type="GeneID" id="102559729"/>
    <dbReference type="KEGG" id="amj:102559729"/>
    <dbReference type="CTD" id="317662"/>
    <dbReference type="OrthoDB" id="2134133at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NZT3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022194">
        <property type="entry name" value="DUF3719"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039630">
        <property type="entry name" value="FAM149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997:SF0">
        <property type="entry name" value="PRIMARY CILIUM ASSEMBLY PROTEIN FAM149B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12516">
        <property type="entry name" value="DUF3719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3719" evidence="3">
        <location>
            <begin position="116"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO42397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="596" mass="66582" checksum="DA7544B1835F3678" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P038</accession>
    <name>A0A151P038_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBE2D1</name>
        <name evidence="12" type="ORF">Y1Q_0022243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P038"/>
    <dbReference type="STRING" id="8496.A0A151P038"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151P038"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="11">
        <location>
            <begin position="51"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO42394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="197" mass="21671" checksum="268C4C9DDD9135E9" modified="2016-06-08" version="1">MLPPNCSPAPITFLPAAQSQQETRKAEQILGSGSSSPTQKLCAGGTLPPTRVGARHNRELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1I0</accession>
    <name>A0A151P1I0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nascent polypeptide-associated complex subunit alpha, muscle-specific form-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0008896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001296">
        <property type="protein sequence ID" value="KYO42956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1I0"/>
    <dbReference type="STRING" id="8496.A0A151P1I0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO42956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="93178" checksum="AEDD0F1EE0C44A63" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2X1</accession>
    <name>A0A151P2X1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2X1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="10598" checksum="BC9040EEAB97FDC7" modified="2016-06-08" version="1">MMDQSSITRICRVDLMMPVTWSPGLLGQTELQSHYHKLAPKIEIFGDICGMSCIEGFLNISACFQSSSIKLERNLGLKDTSEGLIHIDIPLNKSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3S8</accession>
    <name>A0A151P3S8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0013639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3S8"/>
    <dbReference type="STRING" id="8496.A0A151P3S8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO43630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="172" mass="19660" checksum="1600C4829875EAEE" modified="2016-06-08" version="1">MEHKIRIPPGALVRERWRSTPQQLQEEARQEIDMMQRQGIIPLVSVSKPCGSLRLCVDYQKLNVLTAFDAFPMPHIAHLLEKIGETRYIFTIALAGGYWQILMRPSDCAKTAFRTPWALFEFLRMPFGLKGAAATFQRLTDSLLAPDAAYADAYIKDIVIFTTKWTQHLHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P437</accession>
    <name>A0A151P437_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase</fullName>
            <ecNumber evidence="6">3.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EPHX1</name>
        <name evidence="9" type="ORF">Y1Q_0013558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol</text>
            <dbReference type="Rhea" id="RHEA:55764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:139161"/>
            <dbReference type="ChEBI" id="CHEBI:139164"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin</text>
            <dbReference type="Rhea" id="RHEA:23900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:50004"/>
            <dbReference type="ChEBI" id="CHEBI:50014"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.9" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P437"/>
    <dbReference type="STRING" id="8496.A0A151P437"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF70">
        <property type="entry name" value="EPOXIDE HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO43515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="414" mass="47682" checksum="570D40A6286B8945" modified="2016-06-08" version="1">MVETTDEELNDLFRRLDQARFTEPLEDSCFYYGINSVYLRKVVSYWRNQFNWKKQVEVLNKFPHFKTKIDGINVHFLHVKPPHLPEGHSAKPLLMVHGWPGSFYEFYKVISLLTDPASHGLSDEHIFEVICPSIPGYGFSEAPHKQGFDSVCAASVFYKLMLRMGFHEFYAQGGDWGWLICTNLAQIAPNHVKGLHLNLVSVLNMRFTQLLSILLGRYFPGLFGFQEEDVRRMFPFLKKGLYKMLMESGYAHIQATKPDTVGCGLNDSPVGLAAYILEKFSTWTDPEYRKLEDGGLERKYTLDDLLTNVMIYWVSGCMVSAMRFYKENMGKGIGTQKHDKLPVRVPTGVASFPNEIMHTPRSWAQKKYTNIITFNLMPQGGHFAAFEEPELVAADIQQFVGKVEREECWRKMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4B2</accession>
    <name>A0A151P4B2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Neuropeptide S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NPS</name>
        <name evidence="1" type="ORF">Y1Q_0012872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001049">
        <property type="protein sequence ID" value="KYO43904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4B2"/>
    <dbReference type="STRING" id="8496.A0A151P4B2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045760">
        <property type="term" value="P:positive regulation of action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032230">
        <property type="term" value="P:positive regulation of synaptic transmission, GABAergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028138">
        <property type="entry name" value="Neuropeptide_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36679">
        <property type="entry name" value="NEUROPEPTIDE S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36679:SF1">
        <property type="entry name" value="NEUROPEPTIDE S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14993">
        <property type="entry name" value="Neuropeptide_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="162" mass="18406" checksum="BD128E3104926B19" modified="2016-06-08" version="1">MPGTSQVTNTGCSGLPPAIITTENQSPPSIFQWSTPECCHATPSLFRLHFILILWISTMHVCWCYPIVPSSLYGKSDYCLILLNSCLAKVDRSEELAFLKPYLEMSFNKREGTGKEVTYNYCSIKWDPCYCHKSLPAEAFLLSDNCTQGEHILQEEMWPWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5D6</accession>
    <name>A0A151P5D6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box only protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FBXO47</name>
        <name evidence="2" type="ORF">Y1Q_0012062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5D6"/>
    <dbReference type="STRING" id="8496.A0A151P5D6"/>
    <dbReference type="eggNOG" id="ENOG502QV8T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056622">
        <property type="entry name" value="ARM_FBXO47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24467">
        <property type="entry name" value="ARM_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBXO47 ARM repeats region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="398" mass="45573" checksum="63EB2E5C25F3A9E2" modified="2016-06-08" version="1">MVLEHLSVKDISMLSMVSKTISNRLINYISTPSGNRRLLQQDFHNLELSGKRQGSCILEHYRALGLLLKRCTLLLPTKDRLKYIHNILSEVSCFKLNGCPNPLHCLGLQCYGVFLQMLTAGWDELECHRVFNFLCELSNLPRKMQTVVSSKPGSARKLELRIRLYCRSVLLNHWIHRSDSAFWLTRILKPWPMVNQARLLYIIFGPVSSLDGHVVWQKMIEGPTDETSLKGLADAIKLLYDTEAKEWTADDVISLVDELSVVPREWLMENNARLLILSGNNICFTFMASKAVNGRAVELARLMVFLALVCEKDLYCMDWTVKMMQKVCKVFSTPGEKNNFLQSVENAFAHLIMDMLQSVMSGDRDEDDSSFFNLFHLVNAQANFHKEILYLTLRSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5E9</accession>
    <name>A0A151P5E9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5E9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="235" mass="26237" checksum="8B1E727F532550E3" modified="2016-06-08" version="1">MTSQVTCVTKPWHAVAGETDAPTATKRQLAPVGAGCSCVWRESGCGASNIGDGTGFLEDSVQSRDTVRNYDSWDQQLPKTTSSTIKSVEEPSLRPNNMPDVCRERNRVHKFGCWSCLFLTLTCYCWQEVDSRSLENSIQSDDTVGGDDSQDQQLSETTSSTTESCDEPSLRPKHMANISRDTPPHQDSEPTIIVWFQRPDDDTDLPQDVAQHTTKERPERGDWELMSLTSEDMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5G3</accession>
    <name>A0A151P5G3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0001743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000840">
        <property type="protein sequence ID" value="KYO44210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5G3"/>
    <dbReference type="STRING" id="8496.A0A151P5G3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000113">
        <property type="entry name" value="homeobox protein Hox-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO44210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="187" mass="20891" checksum="A5205C3B6C7C7541" modified="2016-06-08" version="1">MNPHPELGWGAQPCRWPGQPRPFLQPPPGSCPGAPACCPERGPAGRGDPRSRLSRDATATFEWMRLKRNPPKSAKIRDCSFAGETHGASPRTNFSTKQLTELEKEFHFNKYLTRARRVEIASALQLNETQVKIWFQNRRMKQKKREKEGLLGGASSYRGHESPSDKSDITSPAISPSRSQEATTPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5J6</accession>
    <name>A0A151P5J6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein Hox-B4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HOXB4</name>
        <name evidence="11" type="ORF">Y1Q_0012103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5J6"/>
    <dbReference type="STRING" id="8496.A0A151P5J6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000419">
        <property type="entry name" value="Homeobox protein Hox-D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO44336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="122" mass="14204" checksum="3A7E5F79C37922AF" modified="2016-06-08" version="1">MLCWSSVQSRGPIGWAPEINPNYTGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHSLCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSNSSNSSASLQIQGGSQNRSSGPATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5K3</accession>
    <name>A0A151P5K3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase lipid-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATPase protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ATP5G1</name>
        <name evidence="18" type="ORF">Y1Q_0012113</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5K3"/>
    <dbReference type="STRING" id="8496.A0A151P5K3"/>
    <dbReference type="GeneID" id="102558448"/>
    <dbReference type="KEGG" id="amj:102558448"/>
    <dbReference type="CTD" id="516"/>
    <dbReference type="eggNOG" id="KOG3025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF56">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="7 16" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="17">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO44351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="139" mass="14561" checksum="005BBC430F9DE273" modified="2016-06-08" version="1">MARPAKMQTPVALLASPALFRCCSRALARPVSVFSRPEIQTVQPSGASHLQLACREFQTSTISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P604</accession>
    <name>A0A151P604_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Histone acetyltransferase</fullName>
            <ecNumber evidence="25">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">KAT7</name>
        <name evidence="28" type="ORF">Y1Q_0012129</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 25">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="25"/>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276749.1">
        <property type="nucleotide sequence ID" value="XM_006276687.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P604"/>
    <dbReference type="STRING" id="8496.A0A151P604"/>
    <dbReference type="GeneID" id="102572511"/>
    <dbReference type="KEGG" id="amj:102572511"/>
    <dbReference type="CTD" id="11143"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P604"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036409">
        <property type="term" value="C:histone H3-K14 acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902035">
        <property type="term" value="P:positive regulation of hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000092">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="22" id="KW-0137">Centromere</keyword>
    <keyword evidence="15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20 25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="27">
        <location>
            <begin position="332"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="23">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KYO44369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="611" mass="70591" checksum="81C8B9D92C51D37D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P693</accession>
    <name>A0A151P693_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neurofilament medium polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NEFM</name>
        <name evidence="14" type="ORF">Y1Q_0016761</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000764">
        <property type="protein sequence ID" value="KYO44459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P693"/>
    <dbReference type="STRING" id="8496.A0A151P693"/>
    <dbReference type="GeneID" id="102563859"/>
    <dbReference type="KEGG" id="amj:102563859"/>
    <dbReference type="CTD" id="4741"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005883">
        <property type="term" value="C:neurofilament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099184">
        <property type="term" value="F:structural constituent of postsynaptic intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045110">
        <property type="term" value="P:intermediate filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006821">
        <property type="entry name" value="Intermed_filament_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23214:SF1">
        <property type="entry name" value="NEUROFILAMENT HEAVY POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23214">
        <property type="entry name" value="NEUROFILAMENT TRIPLET H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04732">
        <property type="entry name" value="Filament_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 10" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="13">
        <location>
            <begin position="96"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="107"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="291"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="514"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="597"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO44459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="846" mass="93963" checksum="DADD92442B72FF79" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7L5</accession>
    <name>A0A151P7L5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000640">
        <property type="protein sequence ID" value="KYO44909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7L5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="12072" checksum="112ED1DCDF3CFF96" modified="2016-06-08" version="1">MVARIGGGSPFKLTPGSRLGSRADIRLRNPQVAWIGGGNPLKLTPGSRLGSRADIRLRNPQGRIDQNHSCAAVNWLQEQERKRLQLKREFAESLTGFGYTEEKNAETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9V3</accession>
    <name>A0A151P9V3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9V3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="10302" checksum="4BE3F1069BB1BAC7" modified="2016-06-08" version="1">MTGAQWQQAQTSQGALGKAEVPCVHGSNPRLAAVPLHAGCIWDPWSHTIFGMAHPPAVVLLPPCFRPLVVFHQLCASLCSCPPGIEKQEDSAGYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDY3</accession>
    <name>A0A151PDY3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000483">
        <property type="protein sequence ID" value="KYO47159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDY3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO47159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="11272" checksum="04A3778C58081BAB" modified="2016-06-08" version="1">MAFYSGQREDEETWILANHSSTIVCCWSKVTYPSLDYANARSWQGRDWGKEPWLQGEAVGPGTRAKHTRRSQDGTTPVKDSFTINAWWKEHFQEHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE31</accession>
    <name>A0A151PE31_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bardet-Biedl syndrome 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BBS7</name>
        <name evidence="6" type="ORF">Y1Q_0001191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PE31"/>
    <dbReference type="STRING" id="8496.A0A151PE31"/>
    <dbReference type="eggNOG" id="ENOG502QPS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016575">
        <property type="entry name" value="Bardet-Biedl_syndrome_7_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056334">
        <property type="entry name" value="BBS7_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056335">
        <property type="entry name" value="BBS7_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056333">
        <property type="entry name" value="BBS7_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056332">
        <property type="entry name" value="Beta-prop_BBS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074:SF4">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23360">
        <property type="entry name" value="BBS7_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23349">
        <property type="entry name" value="BBS7_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23361">
        <property type="entry name" value="BBS7_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23743">
        <property type="entry name" value="Beta-prop_BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011091">
        <property type="entry name" value="BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBS7 beta-propeller" evidence="5">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 GAE" evidence="3">
        <location>
            <begin position="357"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 platform" evidence="4">
        <location>
            <begin position="474"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 helical hairpin" evidence="2">
        <location>
            <begin position="580"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO47376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="696" mass="78062" checksum="DFE0E57C7E77910B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PG75</accession>
    <name>A0A151PG75_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="5 18">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MUTYH</name>
        <name evidence="21" type="ORF">Y1Q_0003594</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="5 18"/>
    <dbReference type="EMBL" id="AKHW03000266">
        <property type="protein sequence ID" value="KYO47993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PG75"/>
    <dbReference type="STRING" id="8496.A0A151PG75"/>
    <dbReference type="eggNOG" id="KOG2457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000026">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="20">
        <location>
            <begin position="332"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO47993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="505" mass="54998" checksum="0D4F6B46E54999EC" modified="2016-06-08" version="1">MGRRPQPGTGPAKRSSGRCRETTAPQRGASCPAPAQPSAFHLFVDTAEIEAFRTSLLAWYDRCKRDLPWRRLAVSEPDVDRRAYSVWVSEVMLQQTQVATVMDYYTRWMQKWPTLQALADASLEEVNALWAGLGYYSRGKRLQEGARKVVSELAGRMPRTAEELQKLLPGVGRYTAGAIASISYGQATGVVDGNVTRVLCRLRCLGADASSPPVTEHLWGLAHTLVDRARPGDFNQALMELGATVCSPKAPLCAECPVRPHCWAQRRVEKELEVASRRLLGKAPSSCPPGPDIEECAAGASGSCPLCPPASEPWDSSLGVANFPRKAAKKQPRAERTATCVLERSGRCGEPEFLIVQRPSSGLLAGLWEFPSLLVAPGLKEKQQREALAGHVRAQTGTAVAAGRLRHVGEVVHVFSHIHQTYVVYSLVLDGPGAAAPVKREEEPELPASRWVTKADFQAAAVSTAMKKVLQACERQSREEKMPCTQSDCCLRLDRSGLDPTGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHW5</accession>
    <name>A0A151PHW5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein 2 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MBLAC2</name>
        <name evidence="2" type="ORF">Y1Q_0004081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHW5"/>
    <dbReference type="STRING" id="8496.A0A151PHW5"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE MBLAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="219" mass="24551" checksum="FE21F2384C5EA069" modified="2016-06-08" version="1">MSALEWFAHKALGGGIYWIQERFYESGNRANIWLFAEVAVHGAEAGALQRGDNYEAVTWLSDREVVRPPGPGWTARSFRVQPVQPTHVLQEGDVISLGDRQLTVMHMPGHSRGSICLHDRDRKILFSGDVVYDGSMIDWLPYSRISDYVASCERLIELVDRGLVEKVLPGHFNTFGAERLYRLASNYIEKAGVCHKVSTCAMRSIASLALRVTNSRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIA9</accession>
    <name>A0A151PIA9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EPH-related receptor tyrosine kinase ligand 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">EFNA5</name>
        <name evidence="17" type="ORF">Y1Q_0004145</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIA9"/>
    <dbReference type="STRING" id="8496.A0A151PIA9"/>
    <dbReference type="eggNOG" id="KOG3858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022407">
        <property type="term" value="P:regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10425">
        <property type="entry name" value="Ephrin-A_Ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000005">
        <property type="entry name" value="Ephrin A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034252">
        <property type="entry name" value="Ephrin-A_Ecto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019765">
        <property type="entry name" value="Ephrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF33">
        <property type="entry name" value="EPHRIN-A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01299">
        <property type="entry name" value="EPHRIN_RBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Ephrin RBD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO48780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="189" mass="21804" checksum="3B714747F1D131C2" modified="2016-06-08" version="1">MKRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSSCDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPANSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRSDNAAQTPRISSLLLATLLFLLAMLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIH6</accession>
    <name>A0A151PIH6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000178">
        <property type="protein sequence ID" value="KYO48850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIH6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="115" mass="11907" checksum="F90647F3B177F1A8" modified="2016-06-08" version="1">MGRGDKLPTGPGGRDPRFLVSPICLEDVWNPRLCSSAFSGCGSASAAPLAQRGLVPAPLIFYPMSPQPHFTLTIMRPGEMFTTGSTFSGSLTANPEGALTAKMTSSVTCGSIANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIK2</accession>
    <name>A0A151PIK2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GC-rich sequence DNA-binding factor 2 isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GCFC2-1</name>
        <name evidence="6" type="ORF">Y1Q_0020219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000178">
        <property type="protein sequence ID" value="KYO48868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIK2"/>
    <dbReference type="STRING" id="8496.A0A151PIK2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF4">
        <property type="entry name" value="INTRON LARGE COMPLEX COMPONENT GCFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCF C-terminal" evidence="5">
        <location>
            <begin position="461"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO48868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="774" mass="89141" checksum="369F9647C4CE7D06" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ74</accession>
    <name>A0A151PJ74_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000093">
        <property type="protein sequence ID" value="KYO49117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ74"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO49117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="129" mass="14071" checksum="7E9056A7A6A8A934" modified="2016-06-08" version="1">MELMVKAVVMVAGLVLAYALMWHCYGRTTKRSKVEDKLHEKPRPRQLKPKCQCGICTDMGARTPEAPAATGKMGALTDDLEPDTGLRHDPLEPRVYLNIPCSTQKKIGPRVAGLHILDVQGAVAGLQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-01-20" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0Q3Z5S2</accession>
    <name>A0A0Q3Z5S2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPL27A</name>
        <name evidence="9" type="ORF">Y1Q_0000678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0Q3Z5S2"/>
    <dbReference type="STRING" id="8496.A0A0Q3Z5S2"/>
    <dbReference type="GeneID" id="102573729"/>
    <dbReference type="KEGG" id="amj:102573729"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="PhylomeDB" id="A0A0Q3Z5S2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000024">
        <property type="entry name" value="RPL27A isoform 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="73"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO22058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="148" mass="16776" checksum="A1995772C3FC3399" modified="2016-01-20" version="1">MPSRLRKTRKLRGHVSHGHGRVGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKVGMRHYHLKKNQYFCPSVNLDKLWTLVSEQTRLNYAKNQAGLAPVIDVVRSGYYKVLGKGKLPKQPVIVKAKFFSRKAEEKIKEVGGTCVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYY7</accession>
    <name>A0A151LYY7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYY7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO17463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="83" mass="9275" checksum="08FEFF83E278D1F7" modified="2016-06-08" version="1">MDASTVENVKAITRTECGSPEIPWQLGYGIGAVEEGELERCSREEKEEANLRGKKEKAGRPQRDQNNLKNHPLPQKACLKIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZE9</accession>
    <name>A0A151LZE9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0005876</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006886">
        <property type="protein sequence ID" value="KYO17647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RDVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000013">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047132">
        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF18">
        <property type="entry name" value="OLFACTORY RECEPTOR 6C76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO17647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="243" mass="27590" checksum="4220D9ADA1BB0B86" modified="2016-06-08" version="1">MYFFISNFSFLEILFTSVTNPKMLLNFITDRKTINFAMCMAQSYFYFAVGATEFAILMVMSFDRYVAICCPLQYVTIMRPRLCVQLVLGSWVGGFSVISLHMVMMSKLRFCGPNVINHFFCDSTPLFQLSCVDTHLIQKMDAILLSTIMFSSLCLTMVSYSXXXFATCTSHLMVVSLAYGSCIFMYARPVTGYALDLNKGVAVLNTILTPFLNPFIYTFRNKNVKLALRDAINHRIAKLSPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0G1</accession>
    <name>A0A151M0G1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GALNT13</name>
        <name evidence="20" type="ORF">Y1Q_0011607</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Golgi apparatus membrane</location>
            <topology evidence="2 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059583360.1">
        <property type="nucleotide sequence ID" value="XM_059727377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059583361.1">
        <property type="nucleotide sequence ID" value="XM_059727378.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059583362.1">
        <property type="nucleotide sequence ID" value="XM_059727379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0G1"/>
    <dbReference type="STRING" id="8496.A0A151M0G1"/>
    <dbReference type="GeneID" id="106736748"/>
    <dbReference type="CTD" id="114805"/>
    <dbReference type="eggNOG" id="KOG3736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151M0G1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23467">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000014">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000005">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF47">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 18" id="KW-0430">Lectin</keyword>
    <keyword evidence="17 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="368"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO17994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="497" mass="57097" checksum="4924EF79A95D2327" modified="2016-06-08" version="1">MGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKPKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHHLLSEVILVDDASERDFLKAALENYVKNLEVPVKIIRMEQRSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKALRENLKCKPFSWYLENIYPDSQIPRRYYSLGEIRNVETNQCLDNMGRKENEKVGIFNCHGMGGNQVFSYTADKEIRTDDLCLDVSRLNGPVIMLKCHHMRGNQLWEYDAEKLTLRHVNSNQCLDEPSEEDKMVPTMKDCSESRSQQWLLRNMTLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0H0</accession>
    <name>A0A151M0H0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nebulin-related-anchoring protein isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NRAP</name>
        <name evidence="8" type="ORF">Y1Q_0011617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M0H0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071691">
        <property type="term" value="P:cardiac muscle thin filament assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11933">
        <property type="entry name" value="SH3_Nebulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000007">
        <property type="entry name" value="nebulin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055297">
        <property type="entry name" value="NEBU/NEBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013998">
        <property type="entry name" value="Nebulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035629">
        <property type="entry name" value="Nebulin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11039">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11039:SF37">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00510">
        <property type="entry name" value="NEBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="182"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="134"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="6616"/>
            <end position="6675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="6532"/>
            <end position="6565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="6595"/>
            <end position="6615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="6553"/>
            <end position="6564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO18011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="6675" mass="773802" checksum="52247504628649F6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0V3</accession>
    <name>A0A151M0V3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lactase-phlorizin hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LCT</name>
        <name evidence="9" type="ORF">Y1Q_0011679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M0V3"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000016">
        <property type="term" value="F:lactase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF38">
        <property type="entry name" value="LACTASE_PHLORIZIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1697"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1710"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="1123"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO18086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1720" mass="195910" checksum="31DE3A4C7AFC29D1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0Z3</accession>
    <name>A0A151M0Z3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Semaphorin-5A isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SEMA5A</name>
        <name evidence="14" type="ORF">Y1Q_0011747</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0Z3"/>
    <dbReference type="STRING" id="8496.A0A151M0Z3"/>
    <dbReference type="eggNOG" id="KOG3611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11264">
        <property type="entry name" value="Sema_5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000048">
        <property type="entry name" value="semaphorin-5B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000021">
        <property type="entry name" value="semaphorin-5B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000003">
        <property type="entry name" value="semaphorin-5B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057563">
        <property type="entry name" value="Sema5A/B-like_TSP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF39">
        <property type="entry name" value="SEMAPHORIN-5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23260">
        <property type="entry name" value="TSP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="13">
        <location>
            <begin position="58"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO18185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1105" mass="124310" checksum="D1EBAE19F6D489AC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M153</accession>
    <name>A0A151M153_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">HepA-related protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sucrose nonfermenting protein 2-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SMARCAL1</name>
        <name evidence="14" type="ORF">Y1Q_0011799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M153"/>
    <dbReference type="STRING" id="8496.A0A151M153"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18010">
        <property type="entry name" value="DEXHc_HARP_SMARCAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001036">
        <property type="entry name" value="SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000026">
        <property type="entry name" value="SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010003">
        <property type="entry name" value="HARP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF6">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07443">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51467">
        <property type="entry name" value="HARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HARP" evidence="13">
        <location>
            <begin position="71"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="HARP" evidence="13">
        <location>
            <begin position="175"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="292"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="563"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO18248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="792" mass="87390" checksum="E7278B4B8285796E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M158</accession>
    <name>A0A151M158_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M158"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="147" mass="16742" checksum="B1447407DCAE313D" modified="2016-06-08" version="1">MRLAAVPIRGFPLVHYKDRGHSHQTDPVVIVAPWRDSNFLVLSVGLTNAHKARTDNKHLPKKTKRLPGALAKAFGPAVFCITCYAHIARRGKKIHRRRISCQQRWCEGANRDQAPIENVQFHVSDVDQKTVQTSVEKKIFCRKLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M374</accession>
    <name>A0A151M374_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M374"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7570" checksum="74B41485BC635E36" modified="2016-06-08" version="1">MFLCRGPANCGPAITADSGRNFQVEDRSSVIVYSKRTHTGTHSFSTTNLQLSSEELICSKMTLLASSFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4L8</accession>
    <name>A0A151M4L8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0015797</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006603">
        <property type="protein sequence ID" value="KYO19462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4L8"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000380">
        <property type="entry name" value="zinc finger protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000869">
        <property type="entry name" value="Zinc finger protein 213"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000017">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000933">
        <property type="entry name" value="zinc finger protein 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001630">
        <property type="entry name" value="Zinc finger protein 888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000047">
        <property type="entry name" value="zinc finger protein OZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="36"/>
            <end position="73"/>
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        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="102"/>
            <end position="129"/>
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            <end position="157"/>
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            <end position="185"/>
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            <begin position="214"/>
            <end position="241"/>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="325"/>
        </location>
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            <end position="353"/>
        </location>
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        <location>
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            <end position="437"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO19462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="438" mass="50317" checksum="8D34103CD8C9C4B0" modified="2016-06-08" version="1">MKSVAVNQHRHVHLGRKTHCCAACRKNICWQDLSQHQCVHSGEQPHHGTKCEKSFRQPSNLARHWCMHTREKPHKCSECRKSFTRSSSLAQHQRIHTGEKPHQCSECGKTFNHSRNLRRHWLIHTAEKPHQCSECGKSYTCSSHLVRHQLIHTGEKPHQCPECGKSFTLSSDLARHQRIHTGEKPHQCSVCGKSFTRSSHLVQHQLIHTEEKPHQCPECGKSFTHSFSLAEHQRIHTGEKPHQCLECGKSFARSSSLAQHHLIHTGEKPYQCLECGKSFTRSSSLAQHQHIHTKEKPHQCSECGKSYTCSSHLIRHQLMHTGEKPHQCSECGKSFTLSSDLARHQRIHTGEKPHQCSECGKSFTRSSHLVQHQLSHTEEKPHQCPECGKSFAHSFHLAQHQRIHTGEKPYHCSQCGKSFIRSFHLARHQLIHTEKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4V2</accession>
    <name>A0A151M4V2_ALLMI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
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                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
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            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7603" checksum="5B9C8E857DF2208C" modified="2016-06-08" version="1">MDPIWAGVSSHMYTLETRMDLWDVVLVVFKDKQCVIPVLGKEEGSGAEGAVQGVVFKCKTDDRRDECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M672</accession>
    <name>A0A151M672_ALLMI</name>
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        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006505">
        <property type="protein sequence ID" value="KYO19930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M672"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin heavy variable V15-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0391">Immunity</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
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            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="181"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KYO19930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="208" mass="22195" checksum="B62ED4007882329F" modified="2016-06-08" version="1">MKAPLLVLALLSCLPCVLSSVTLVQSGPGVVKPGETLSLTCAVSGVQAEVQLVDSPVNGLEPTTAVMKRSGCTRLLGKGWSVLSAVQLVESGPGVANPAETLTLTCTVTGFSITTSNYYWSWIQQPPGKGLEWMEYMSYSGSTGYNPTFKSHITISRDTSKSQFSLKLGSLTAADTATYYCARDTVTERGSLFFLMQPNCNSDREVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6K1</accession>
    <name>A0A151M6K1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gastrotropin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FABP6</name>
        <name evidence="7" type="ORF">Y1Q_0010713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019333939.1">
        <property type="nucleotide sequence ID" value="XM_019478394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6K1"/>
    <dbReference type="STRING" id="8496.A0A151M6K1"/>
    <dbReference type="GeneID" id="102566576"/>
    <dbReference type="KEGG" id="amj:102566576"/>
    <dbReference type="CTD" id="2172"/>
    <dbReference type="eggNOG" id="KOG4015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10016075at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M6K1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19446">
        <property type="entry name" value="FABP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000006">
        <property type="entry name" value="Fatty acid-binding protein, liver"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="6">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO20136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="128" mass="14360" checksum="10710EC1539763D9" modified="2016-06-08" version="1">MAFTGKYEVESEENYDDFMKRIGLPSDVIEKGRNFKIVTEVVQNGEEFIWSQHYPGGQSMTNKFTIGKEAEMETMSGKKFKATVKMENGKVVADFPNYHHTAEIAGGKLLEISVAAGVTYKRISKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6N8</accession>
    <name>A0A151M6N8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prenylcysteine oxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PCYOX1L</name>
        <name evidence="10" type="ORF">Y1Q_0010734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6N8"/>
    <dbReference type="STRING" id="8496.A0A151M6N8"/>
    <dbReference type="eggNOG" id="ENOG502QSHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000081">
        <property type="entry name" value="prenylcysteine oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF2">
        <property type="entry name" value="PRENYLCYSTEINE OXIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="123"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO20164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="492" mass="54750" checksum="D004F24261365C46" modified="2016-06-08" version="1">MSFPAEIGKPAGGDNPPCARADVPASLASLLAAVVGAGIGGSAVAYFLQQHFGPRVQLDVYEKGSVGGRLATITVNKQQYESGGASVHSLNLHMQDFVKLLGLKHRREVAGKSAIFGGEHFVLEETDWYLLNLFRLWWHYGISFLRLQMWVEEVMEKFMRIYKYQAHGYAFSSLEELLHSLGGEAFINMTQRSVAESLLEAGVTQRFIDDVIAAVLRSSYGQSMLLVPAFAGAMSLAGAQGNTWAVEGGNKLVCSGLLKLTKANVVHARVTNVSLHSAEGKPLYQVRYEDEEGQGSGFYDMVVIAAPLHHGKSNLTFENFDPPIPELSGSFQPTVTSVVHGYLNSSYFGFPDPKLFPFASILTTDTPNLFFNAMDNICPVNISSSFRRKQPQEPAVWRVLSQQPLDKQQLKTLFRSYYSVQVTEWQAYPYYDSTKTLPPIVLHDNLFYLSGVEWVASSMEMISMAAKNVALLAYNRWYQDLEKIDQKDLMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M713</accession>
    <name>A0A151M713_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M713"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="143" mass="16764" checksum="63F4E960A7D87167" modified="2016-06-08" version="1">MRRWHSGDRLVQRGDSFQEGKWSSKRLSSQDCFSQSSAIPRSQQKKEGKRRRKEHHKAIEDAQNPTNWLRTYPKKKRSNTSRGLDISSHNEQKTPLHTSEVPHPLLLQMLSGCEMLLNQREEQHRNTAAVKREDRLVVGWLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7K2</accession>
    <name>A0A151M7K2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006392">
        <property type="protein sequence ID" value="KYO20477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7K2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="77" mass="9057" checksum="1273A38ED0F106B9" modified="2016-06-08" version="1">MWRSLLHVGVERALWSGYSNSLQTLLPDPCARVERIQLHLPVEQVCIRAKHVQDHVLKWLMIINEQLAIAKRERQCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7W3</accession>
    <name>A0A151M7W3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0023213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006361">
        <property type="protein sequence ID" value="KYO20530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7W3"/>
    <dbReference type="STRING" id="8496.A0A151M7W3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001230">
        <property type="entry name" value="Immunoglobulin kappa variable 8-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584826" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO20530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="137" mass="15018" checksum="378A0BB9F4F9FEE5" modified="2016-06-08" version="1">MISHIQLLWLFVFWLHGSSGDIVITQTPESLAVSPGDTVTIKCKTSSSVSSSNMHFYQQKPGQAPKLLLYSTSNRPSGIPDRFSGSGSGTDYTFTISRMEAGDAGDYYCQQTNSWPLTVIQSSTKTPLDFCGFLFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M840</accession>
    <name>A0A151M840_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Teratocarcinoma-derived growth factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TDGF1</name>
        <name evidence="7" type="ORF">Y1Q_0012569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M840"/>
    <dbReference type="STRING" id="8496.A0A151M840"/>
    <dbReference type="GeneID" id="102568078"/>
    <dbReference type="KEGG" id="amj:102568078"/>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9893603at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000421">
        <property type="entry name" value="Teratocarcinoma-derived growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019011">
        <property type="entry name" value="Cryptic/Cripto_CFC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09443">
        <property type="entry name" value="CFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584841" evidence="5">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO20684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="186" mass="20991" checksum="973AD51AE035D824" modified="2016-06-08" version="1">MKFVRLFLSIALSLQVIHFGNGCKENCNNNPDQKNQSTSLNTFTAINNLNSERRRRNPSEILPFTGLTRSSKLNKNCCQNGGTCFLGSFCICPKYFAGRYCEHDKRIRSCDAIGHGEWTQEGCFLCQCLYGILNCFPQSVEERCGPTKKKLPDWIQPGISSEGLKLQMTKYILTASLLFSLLCQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCH4</accession>
    <name>A0A151MCH4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Chemokine-like receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0024399</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chemokine-like receptor (CMKLR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006265">
        <property type="protein sequence ID" value="KYO22204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="amj:106740299"/>
    <dbReference type="OrthoDB" id="6088892at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004875">
        <property type="term" value="F:complement receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004982">
        <property type="term" value="F:N-formyl peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000034">
        <property type="entry name" value="G-protein coupled receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000826">
        <property type="entry name" value="Formyl_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225">
        <property type="entry name" value="CHEMOTACTIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225:SF0">
        <property type="entry name" value="N-FORMYL PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00526">
        <property type="entry name" value="FMETLEUPHER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO22204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="342" mass="38631" checksum="894229AB40AB34E1" modified="2016-06-08" version="1">METSSPTSSPGTGNHDKLTRGIHIFSMIIYSIAFLLGVTGNGLVIWVTGFHMKRTVNTVWFLNLAIADFIFTFFLPLNITSIAMNFHWPFGRALCKLNGGLASLNLYASVFFLTVISLDRCVCVVSPVWTQNHRQPRLASLVALGIWILSLILCIPYWYFREIXXXXXXXXXXXXXXXXTTGEEATEEEWKWVSTSNSRATVISRFIFSFIIPFYIIVICYGVIVVKLLTSQLALSSKPFKIIAVVIVVFFLCWFPLHVFSFLEMDDLPKFRTAVHIGMPLVSSLAFVNSCLNPILYVFMAHDFKEKLRHSLFLAFEKAFTEDAPIVAVQTQSTMKSDSQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF83</accession>
    <name>A0A151MF83_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF83"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9162" checksum="E0368E7D2B223BBE" modified="2016-06-08" version="1">MLPITDSTRNVNAEWICLTLGNLTENTDCIRGLQGMKNGLSCPFAAFPPPVKTGRWKGTGANPSECSAFSCESHWCEKEQLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFN2</accession>
    <name>A0A151MFN2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFN2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO23325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="161" mass="18490" checksum="3F10A0F70B440338" modified="2016-06-08" version="1">MDWGVWEDSATHLCIIVCENFKENAFAVKLPETAFLRQNLLDWIFTFRLCCSVLQPIFSLFLVLCYNLYSQWERLGQEMAGKQEIRNQKFEPCPLCLRRCLDTSNTVPVSGKIHQSCMKKSVGLAADYPAWNRLHDGKKHQTDMAGNKTFLIHGTATEVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGU4</accession>
    <name>A0A151MGU4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0002336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGU4"/>
    <dbReference type="STRING" id="8496.A0A151MGU4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO23713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="296" mass="33584" checksum="B68C49DA066DAECB" modified="2016-06-08" version="1">MASTYLSPGWGVAKPGRPNEARLVVDYREVNKRCQPLAQPTQSTLLQCMLEMARDQAYPWVRVTLDLKNMFFSIPLTNPNGVLNMCVEEIMYKWTVCPQGYRNSPSLATGAMNRTLETFAATNDNLWNEECKIWNYIDDISIMGRNTTVVRETATHLVNHLQKDGWTVNSEKSHLHPTANITFLGTTFDGTTRRGATHGPPDLEPLIHSLPTDKRSLQRLLGHLSWYPHYVPPRHLPIVAKLQRQLREKTQKSTPWTARDDDHLRRLLPAIKNTSLAAINLNEPLVVTLGYAATHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJ82</accession>
    <name>A0A151MJ82_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand domain-containing protein D2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EFHD2</name>
        <name evidence="6" type="ORF">Y1Q_0023220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJ82"/>
    <dbReference type="STRING" id="8496.A0A151MJ82"/>
    <dbReference type="eggNOG" id="KOG0041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000112">
        <property type="entry name" value="EF-hand domain family, member D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO24523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="16620" checksum="B8D68467E151860D" modified="2016-06-08" version="1">MERLFRQYDAGKDGFIDLMELKLMMEKLGAPQTHLGLKNMIKEVDEDLDSKLSFREFLLIFRKAAAGELQEDSGLHALARLSEIDVSTEGVKGAKSFFEAKVQAINDASRFEEEIKAEQEEKKKQAEEMKQRKAAFKELQSTFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJA3</accession>
    <name>A0A151MJA3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adaptin ear-binding coat-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NECAP2</name>
        <name evidence="9" type="ORF">Y1Q_0023268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NECAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014457363.1">
        <property type="nucleotide sequence ID" value="XM_014601877.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJA3"/>
    <dbReference type="STRING" id="8496.A0A151MJA3"/>
    <dbReference type="GeneID" id="102559268"/>
    <dbReference type="KEGG" id="amj:102559268"/>
    <dbReference type="CTD" id="55707"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000064">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF16">
        <property type="entry name" value="ADAPTIN EAR-BINDING COAT-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NECAP PHear" evidence="8">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO24586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="263" mass="28520" checksum="13BC6543B0D47669" modified="2016-06-08" version="1">MADGDYESVLCVKPEVHVYRVPPRASNRGHRAAEWQLDQPAWSGRLRITSKGKMAFIKLEDKTTGELFAQAPVDQFPGIAVESVTDSSRYFVVRIEDGNGRRAFIGVGFVDRGDAFDFNVALQDHFKWVRQQSEFAKQAQNPEQGPKLDLSFKEGQTIKLNIANMKKKEGAAASSRSRPAGPGGLSLLPPPPGGKGPAMIPPLGEQPPSFPTHSQLPGPANPDTPLPWPQPSATATTDVWGDFARASGSASSQNQQSTGWVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJH3</accession>
    <name>A0A151MJH3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorting nexin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SNX3</name>
        <name evidence="8" type="ORF">Y1Q_0017790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006032">
        <property type="protein sequence ID" value="KYO24691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258574.1">
        <property type="nucleotide sequence ID" value="XM_006258512.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJH3"/>
    <dbReference type="STRING" id="8496.A0A151MJH3"/>
    <dbReference type="GeneID" id="102563160"/>
    <dbReference type="KEGG" id="amj:102563160"/>
    <dbReference type="CTD" id="8724"/>
    <dbReference type="eggNOG" id="KOG2527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MJH3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051223">
        <property type="term" value="P:regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000002">
        <property type="entry name" value="Sorting nexin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF1">
        <property type="entry name" value="SORTING NEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO24691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="162" mass="18743" checksum="E2502BC7616558E5" modified="2016-06-08" version="1">MAETVADTRRLLSKPQNLNDAYGPPSNFLEIDVGNPQTTGVGRARFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRNELERESKVVVPPLPGKALLRQLPFRGDDGIFDDSFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEVIDKNYTPSKIRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK60</accession>
    <name>A0A151MK60_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM and cysteine-rich domains protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LMCD1</name>
        <name evidence="11" type="ORF">Y1Q_0023782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK60"/>
    <dbReference type="STRING" id="8496.A0A151MK60"/>
    <dbReference type="eggNOG" id="KOG1704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09340">
        <property type="entry name" value="LIM1_Testin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09829">
        <property type="entry name" value="PET_testin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033724">
        <property type="entry name" value="PET_testin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF0">
        <property type="entry name" value="LIM AND CYSTEINE-RICH DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="10">
        <location>
            <begin position="94"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="236"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO24914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="347" mass="38894" checksum="DB9A5B7F836DFF44" modified="2016-06-08" version="1">MDLSPGIQKMSVSQQQSGRGVPCLRCRGMCTGFEPHSWRKICKSCKCSQEDHSLSSDAEDDRKIGRLLSESKYSTLTARVKGGDGVRIYKRNRMIITNPIVSRKDPTFDTITYEWAPPGLTQKLAIQYMELIPKKMQPIAGTEGAYYRRRQLMRQLPIYDQDPSHCRGLAENEIKLMEDFVKKYKNDALGVGEVALPGQGGSAKEEGKHQDKNAGTSKPSVSTNGALSGPPAGAEYCCEICKQVMPTNCPVVYADRAGYSHQWHPACFVCCKCSDPLVDLIYFWKNGAVWCGRHYCESIRPRCAACDEIIFSEDYQQENGLTWHKKHFTCLESKASIPKHQSKGCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLM2</accession>
    <name>A0A151MLM2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-ketoglutarate-dependent dioxygenase alkB-like protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ALKBH6</name>
        <name evidence="10" type="ORF">Y1Q_0015360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005839">
        <property type="protein sequence ID" value="KYO25339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLM2"/>
    <dbReference type="STRING" id="8496.A0A151MLM2"/>
    <dbReference type="eggNOG" id="KOG3200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="96"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO25339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="200" mass="22216" checksum="FAD95F5988BBB74F" modified="2016-06-08" version="1">MEVLSPRVPGLDPFRVQEAPPAAYYVPDFISEAEEARLLQQVYAAPKPKWTQLSGRRLQNWGGLPHPKGLVPEPLPPWLQYWVEEVSALGVFGGQAANHVLVNEYCPGQGIMPHEDGPLYFPTVTTVSLGSPTLLDFYRPVCTEVPGDEPQVPAAQTEEQRHVLSLLLEPRSLLVLREELYSRYLHGIRAATSDALTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLM9</accession>
    <name>A0A151MLM9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005879">
        <property type="protein sequence ID" value="KYO25290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLM9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7388" checksum="574EF815FC689849" modified="2016-06-08" version="1">MMVSRWKTLLFASHRAWQPGLAVSQKGKAALPRLWGTVLGSPAGKKERGPSQPRQLCIHSEQHKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLQ5</accession>
    <name>A0A151MLQ5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein spinster homolog 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spns1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SPNS1</name>
        <name evidence="17" type="ORF">Y1Q_0016057</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:74447"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:77287"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:74455"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:77288"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:74435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:74439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64381"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005789">
        <property type="protein sequence ID" value="KYO25455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLQ5"/>
    <dbReference type="eggNOG" id="KOG1330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF13">
        <property type="entry name" value="PROTEIN SPINSTER HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO25455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="463" mass="49216" checksum="78C32C6DBDC32826" modified="2016-06-08" version="1">MVAVLCYVNLLNYMDRFTVAGVLPEIEAYFGIGDGSSGLLQTVFISSYMVLAPLFGFLGDRSSRRLLLCVGIALWSTVTLASSFVPRQHFWLLLLTRGLVGVGEASYSTVAPTIIADLFVGDRRSRMLGFFYFAIPVGSGLGYMAGSKVKDVMHDWHWALRVTPGLGVVAVVLLLLVMKEPPRGAVERHGPPSPLHYTSWCDDVRALARNRSFVLSSLGFTAVAFVTGALALWAPAFLQRARLAAGAPPADDSLVFGAVTCVTGVLGVGAGVELSRRLRLRSSRADPLVCAIGLLGAAPCLFLAVALARASIPVTYVFIFIGETLLSLNWALVADILLYVVVPTRRSTAEALQIVMSHLLGDAGSPYLVGVMSDAVRRHRPPTPLWAFRSLGYALTLCAFVGALGGGFFLATALVLPADRRRAHLQAQGLLAEAGGSPGAASERIVVPRGGRAAQLPVSSVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MM02</accession>
    <name>A0A151MM02_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="11">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PCYT1A</name>
        <name evidence="16" type="ORF">Y1Q_0013745</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>phosphocholine + CTP + H(+) = CDP-choline + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18997"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.7.7.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:18998"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03005724">
        <property type="protein sequence ID" value="KYO25577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MM02"/>
    <dbReference type="STRING" id="8496.A0A151MM02"/>
    <dbReference type="eggNOG" id="KOG2804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF19">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="15">
        <location>
            <begin position="166"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="399"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO25577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="453" mass="51333" checksum="E22CC12F7B24F9CF" modified="2016-06-08" version="1">MAERPRKHHCKSKRCLLCEAPFPGTAEGELCPECDAPLPVARLDLDAEWRSRPLSPGPARASAGAPRQDKRQAQVSPADVPGTSKKMEAPTSSRLNSRKRRKEGPGPNGAAELDGIPAKMSRRAFSLREPAPFSDEIEIDYSKPYARVTFEEALRGTPLDRPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLKEHRIDFVAHDDIPYSSAGSDDVYKHIKDAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKRYHLQERVDKVKKRVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGNFLEMFGPEGALKHMLKEGKGRMLQAISPRQSPSSSPTHDRSPSPSFRWPFSAKTPPASPANRARNEAAITYDISEDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMG5</accession>
    <name>A0A151MMG5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMG5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="11511" checksum="87C65040DA6720FB" modified="2016-06-08" version="1">MAPVPDSKMRKWRLKAATEQGPVLQEASGSRGPACVCRAVIMRLRLLTPAYFRLLQLQLSGVLECEPKDRLVNHTALLLAIMGLSLSYYSVRQLAKPVKPPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN37</accession>
    <name>A0A151MN37_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hairy/enhancer-of-split related with YRPW motif protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HEY1</name>
        <name evidence="13" type="ORF">Y1Q_0003721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HEY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276029.2">
        <property type="nucleotide sequence ID" value="XM_006275967.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN37"/>
    <dbReference type="STRING" id="8496.A0A151MN37"/>
    <dbReference type="GeneID" id="102574555"/>
    <dbReference type="KEGG" id="amj:102574555"/>
    <dbReference type="CTD" id="23462"/>
    <dbReference type="eggNOG" id="KOG4304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000012">
        <property type="entry name" value="hairy/enhancer-of-split related with YRPW motif protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="12">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO25934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="304" mass="32797" checksum="4ED35650B0F697DA" modified="2016-06-08" version="1">MKRTHADFSSSDSEELDEPIEVEKESADEQGTLSPAAGALSPATASQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASSVHAGIGHIPWGSAFGHHPHISHPLLLPQNGHGNTSTTASSTEPHHQSRIAAHAETSSLRVPPNGSIGSLLPVVTSTSKLSPPLLSSMASLSAFPFSFGPFHLLSPNALSPSAPTQSANLGKPYRPWGTEIGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRD2</accession>
    <name>A0A151MRD2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CNOT10</name>
        <name evidence="5" type="ORF">Y1Q_0019379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CNOT10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273308.1">
        <property type="nucleotide sequence ID" value="XM_006273246.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRD2"/>
    <dbReference type="STRING" id="8496.A0A151MRD2"/>
    <dbReference type="GeneID" id="102572885"/>
    <dbReference type="KEGG" id="amj:102572885"/>
    <dbReference type="CTD" id="25904"/>
    <dbReference type="eggNOG" id="KOG2471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25157at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MRD2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000092">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039740">
        <property type="entry name" value="CNOT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979:SF5">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO26969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="745" mass="82460" checksum="411C36D456601971" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSQ7</accession>
    <name>A0A151MSQ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase AMFR</fullName>
            <ecNumber evidence="12">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Autocrine motility factor receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">AMFR</name>
        <name evidence="20" type="ORF">Y1Q_0003691</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="12"/>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSQ7"/>
    <dbReference type="STRING" id="8496.A0A151MSQ7"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14421">
        <property type="entry name" value="CUE_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16455">
        <property type="entry name" value="RING-H2_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000149">
        <property type="entry name" value="E3 ubiquitin-protein ligase AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040675">
        <property type="entry name" value="AMFR_Ube2g2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18442">
        <property type="entry name" value="G2BR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="19">
        <location>
            <begin position="391"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="524"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO27541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="578" mass="66913" checksum="569BC4B5EF46FC73" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MT53</accession>
    <name>A0A151MT53_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pulmonary surfactant-associated protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LL</name>
        <name evidence="21" type="ORF">Y1Q_0005246</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Oligomeric complex of 6 set of homotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Surface film</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the SFTPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MT53"/>
    <dbReference type="STRING" id="8496.A0A151MT53"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF13">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0176">Collagen</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="6" id="KW-0305">Gaseous exchange</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0767">Surface film</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585431" description="Pulmonary surfactant-associated protein A" evidence="19">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="20">
        <location>
            <begin position="258"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO27687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="372" mass="40008" checksum="9366078FD0A6BEE5" modified="2016-06-08" version="1">MLLPQILGAVVAFLVACHAEEPCTGIPGIPGTPGTNGLPGRDGRDGMKGDPGPPGSQGPPGGMMGPPGRDGLPGLTGPKGDQGEKGERGEPGQRGLPASFDTELHSILSTLRHHIAALEGVLALEGTITRVGEKMLATNGKEVDFATTLHVCERAGGSVAAPRNEEENNAILSIVKRFNRYAYLGIKETPIPALTLLLVTCYAEKECIVSGKGTMATQGQQGLPLSPDIELQKMLQSLEDRILQLERVLILTKQITEYGGKLFATNGKSEDFETIFHTCKNAGGFIVSPRNEGENNAILEFVKQFNTYAYLGIKEGLLPGEFLYLDNTKVSYTNWYSGEPSGRGTTTCVEMYTDGTWNDKKCNYDRLTVCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTF6</accession>
    <name>A0A151MTF6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Complexin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CPLX2</name>
        <name evidence="17" type="ORF">Y1Q_0004716</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complexin/synaphin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005092">
        <property type="protein sequence ID" value="KYO27792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTF6"/>
    <dbReference type="STRING" id="8496.A0A151MTF6"/>
    <dbReference type="KEGG" id="amj:102560873"/>
    <dbReference type="eggNOG" id="ENOG502RXXI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22740">
        <property type="entry name" value="Complexin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.580:FF:000001">
        <property type="entry name" value="Complexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.580">
        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF9">
        <property type="entry name" value="COMPLEXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO27792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="119" mass="13772" checksum="D3B8EEAE7C83FAE9" modified="2016-06-08" version="1">MGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAEREKVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEDEDEEESILDTVLKYLPGPLQDMFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVQ1</accession>
    <name>A0A151MVQ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 81-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0005324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004889">
        <property type="protein sequence ID" value="KYO28518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVQ1"/>
    <dbReference type="KEGG" id="amj:109285415"/>
    <dbReference type="OrthoDB" id="125906at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026295">
        <property type="entry name" value="CCD81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040673">
        <property type="entry name" value="CCDC81_HU_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028034">
        <property type="entry name" value="HU-CCDC81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14362">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14362:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14908">
        <property type="entry name" value="HU-CCDC81_euk_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18289">
        <property type="entry name" value="HU-CCDC81_euk_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC81 HU" evidence="2">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC81 HU" evidence="3">
        <location>
            <begin position="103"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC81 HU" evidence="2">
        <location>
            <begin position="299"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC81 HU" evidence="3">
        <location>
            <begin position="396"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="721" mass="82217" checksum="E62F65CC1AA4B4BF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWT0</accession>
    <name>A0A151MWT0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Interleukin-7 receptor subunit alpha isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">IL7R-1</name>
        <name evidence="15" type="ORF">Y1Q_0009818</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWT0"/>
    <dbReference type="STRING" id="8496.A0A151MWT0"/>
    <dbReference type="eggNOG" id="ENOG502S4WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8611929at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040997">
        <property type="entry name" value="FN3_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003531">
        <property type="entry name" value="Hempt_rcpt_S_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037:SF27">
        <property type="entry name" value="INTERLEUKIN-7 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18447">
        <property type="entry name" value="FN3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01355">
        <property type="entry name" value="HEMATOPO_REC_S_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585528" evidence="13">
        <location>
            <begin position="24"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="IL-7Ralpha fibronectin type III" evidence="14">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO29001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="431" mass="48489" checksum="5E12B0C3E065194B" modified="2016-06-08" version="1">MLRMTRTSAAFSILLFLLHTASGESCCTSADGDGTFGDDELDNPEIDCFSQLEIVSSLHALICSFSEPSLNNTNFQIVSCISEERIEKCSQMKKQESTYSLEFSQILLPRRVCVILESKRKYCSSLKVISIVKPEKPFNVTITFQEAANEYLVQYKTPHSTKRYLSGKLIHQISYRWQKGSWSTIESQYLQIKLLGRNLEMGAVYELKVRSKPNGNFFNGTWSDWSTSEFFTTEMKPPLEKNSDMIMVTLCTVGFIFSVIVIVLILTFWKNRIKPLVWPNLPDHKKTLEQLCKKPKNQFDTSFNPESFGYVHIHKVDNIQAKTETECFLQPSTPPEADVSEKVKSGSELKSSPIGTGTCNLKLLFTYGGIWPSDALNGCSCPTLLPNGVGFSSAITYPEGSSSAKQWRNDDVRTHSSSAMDAMTQHRDGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MY23</accession>
    <name>A0A151MY23_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MY23"/>
    <dbReference type="STRING" id="8496.A0A151MY23"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF84">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17899" checksum="FD06171556199F5D" modified="2016-06-08" version="1">MTLHLHLSQNQCSTVISTYSPTLGSDEQVKERFYSDLDNVFAFIPRDDKVILLGKFNTQVDCEHEIWTGTIGKNGVGKANANGILLLIKCAQHNMIVMNNVFFQKDQLKIKWKQLRSEHCHLLDYIIIQGRDLRDVLVTKVMKGFEDAGQTTDLCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZC6</accession>
    <name>A0A151MZC6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellular nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CNBP</name>
        <name evidence="7" type="ORF">Y1Q_0023204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZC6"/>
    <dbReference type="STRING" id="8496.A0A151MZC6"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000002">
        <property type="entry name" value="cellular nucleic acid-binding protein-like isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000026">
        <property type="entry name" value="cellular nucleic acid-binding protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO29872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="142" mass="15808" checksum="416AD1770DBC3EAE" modified="2016-06-08" version="1">MRSRGRGFQFMSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1S7</accession>
    <name>A0A151N1S7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CHST12</name>
        <name evidence="13" type="ORF">Y1Q_0008323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276805.2">
        <property type="nucleotide sequence ID" value="XM_006276743.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019350368.1">
        <property type="nucleotide sequence ID" value="XM_019494823.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019350371.1">
        <property type="nucleotide sequence ID" value="XM_019494826.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059572188.1">
        <property type="nucleotide sequence ID" value="XM_059716205.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059572189.1">
        <property type="nucleotide sequence ID" value="XM_059716206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1S7"/>
    <dbReference type="STRING" id="8496.A0A151N1S7"/>
    <dbReference type="GeneID" id="102565939"/>
    <dbReference type="KEGG" id="amj:102565939"/>
    <dbReference type="CTD" id="55501"/>
    <dbReference type="eggNOG" id="KOG4651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF4">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO30708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="419" mass="49378" checksum="4AB09F9ED3548C92" modified="2016-06-08" version="1">MTKARLFRLSVVLGSIFMILLIIVYWDNVGTTHFYLHTSFSRLHPLGALPTVAQDKDREALSDVDEFLEKLLSSGLRQNSLSTRKTEQPPPQGSSQPVLGNLEENVRGYDWSTHDARVSLDQEKLQAERRRMLQEFCANSSFAFPTKERSFDDIPNYELNHLIVDDRHGIIYCYVPKVACTNWKRVMIVLSESLLDQGVPYRDPLDIPREHVHNTSTHLTFNKFWRRYGKFSRHLMKIKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRRFAIPMLKLYSNHTNLPTSVSEAFGAGLKVSFSDFIQYLLDPRTEKMAPFNEHWRQVYRLCHPCQIDYDFIGKLETLDEDAAHLLQLLKVDRLLRFPPSYRNRTASSWEEDWFAKIPLAWRRQLYKLYEADFVLFGYPKPENLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N207</accession>
    <name>A0A151N207_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor SOX-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SOX8</name>
        <name evidence="9" type="ORF">Y1Q_0014333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004153">
        <property type="protein sequence ID" value="KYO30814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006269217.1">
        <property type="nucleotide sequence ID" value="XM_006269155.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N207"/>
    <dbReference type="STRING" id="8496.A0A151N207"/>
    <dbReference type="GeneID" id="102561095"/>
    <dbReference type="KEGG" id="amj:102561095"/>
    <dbReference type="CTD" id="30812"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N207"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048484">
        <property type="term" value="P:enteric nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007422">
        <property type="term" value="P:peripheral nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22031">
        <property type="entry name" value="HMG-box_SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000004">
        <property type="entry name" value="Transcription factor SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022151">
        <property type="entry name" value="Sox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12444">
        <property type="entry name" value="Sox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO30814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="471" mass="50910" checksum="AEF7811A1C8074BA" modified="2016-06-08" version="1">MLDMTEERDKALEPPCSPAGTASSMSPADSDSDAPLSPAGSDGLGCAAPAAPRPPSKGDPSAAAAAEVDERFPACIRDAVSQVLKGYDWSLVPMPVRGNGALKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSENEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKAGQSDSDSGAELSHHAGSQIYKADTGLGGMADSHHHGDHTGQTHGPPTPPTTPKTDLHHGSKQELKHEGRRLAESGRQNIDFSNVDISELSSEVINNMETFDVHEFDQYLPLNGHSAMPADHGQNSSAGSYGTSYSHSAAGSGGAAQVWTHKSPSSASPPSNETGQQRPHIKTEQLSPSHYSDQSHGSPAHSDYSSYSSQACATTASSATAAASFSSSQCDYTDLQSSNYYNPYPGYASSIYQYPYFHSSRRPYATPILNGLSIPPSHSPTANWDQPVYTTLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N236</accession>
    <name>A0A151N236_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome transmission fidelity protein 18 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHTF18</name>
        <name evidence="12" type="ORF">Y1Q_0014339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004153">
        <property type="protein sequence ID" value="KYO30822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014463934.1">
        <property type="nucleotide sequence ID" value="XM_014608448.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N236"/>
    <dbReference type="STRING" id="8496.A0A151N236"/>
    <dbReference type="GeneID" id="102564459"/>
    <dbReference type="KEGG" id="amj:102564459"/>
    <dbReference type="CTD" id="63922"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001083">
        <property type="entry name" value="Chromosome transmission fidelity factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000074">
        <property type="entry name" value="Chromosome transmission fidelity protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="405"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="906"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO30822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114558" checksum="6F3BA3EB92726FA7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3L1</accession>
    <name>A0A151N3L1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3L1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="8190" checksum="847997E5CC690769" modified="2016-06-08" version="1">MSLDFSREEACTWATLIKASGQIHIGCNRDERKDERNQDEFSRQLKRFGERNTATRSCFQLLSEQLSGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4C3</accession>
    <name>A0A151N4C3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0006026</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4C3"/>
    <dbReference type="STRING" id="8496.A0A151N4C3"/>
    <dbReference type="eggNOG" id="KOG0695">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21095">
        <property type="entry name" value="C1_aPKC_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06404">
        <property type="entry name" value="PB1_aPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05617">
        <property type="entry name" value="STKc_aPKC_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000071">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000070">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000012">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034662">
        <property type="entry name" value="aPKC_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047314">
        <property type="entry name" value="C1_aPKC_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034877">
        <property type="entry name" value="PB1_aPKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012233">
        <property type="entry name" value="PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000554">
        <property type="entry name" value="PKC_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="21">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="19">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="252"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="519"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="258"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000554-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000554-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO31439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="609" mass="70397" checksum="217C55B6846B9B05" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5H8</accession>
    <name>A0A151N5H8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5H8"/>
    <dbReference type="STRING" id="8496.A0A151N5H8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO31835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="175" mass="19173" checksum="8ECD7EABBCF581DD" modified="2016-06-08" version="1">MRTQAEMAHTCRGTINLSTAHIDTEDSCNIVLSNGGRTYHLKASSEVERQRWVTALELAKAKAIRMRNNQSDLGELHASIPAGSDGYSLATSLATYMRNLRVPSAAHFCSSLQTHLIMMASLACFPVKLQHGWIVCLCFAAVLRCNLCAVGEHSSLPHWSVASQRVYPGTVNMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5Z1</accession>
    <name>A0A151N5Z1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0007169</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HNF1 homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5Z1"/>
    <dbReference type="STRING" id="8496.A0A151N5Z1"/>
    <dbReference type="KEGG" id="amj:102558357"/>
    <dbReference type="eggNOG" id="ENOG502QRPW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10069265at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031016">
        <property type="term" value="P:pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000043">
        <property type="entry name" value="Hepatocyte nuclear factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000009">
        <property type="entry name" value="Hepatocyte nuclear factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039066">
        <property type="entry name" value="HNF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006899">
        <property type="entry name" value="HNF-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044869">
        <property type="entry name" value="HNF-1_POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023219">
        <property type="entry name" value="HNF1_dimer_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006897">
        <property type="entry name" value="HNF1b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044866">
        <property type="entry name" value="HNF_P1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11568">
        <property type="entry name" value="HEPATOCYTE NUCLEAR FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11568:SF2">
        <property type="entry name" value="HEPATOCYTE NUCLEAR FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04814">
        <property type="entry name" value="HNF-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04812">
        <property type="entry name" value="HNF-1B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100957">
        <property type="entry name" value="Dimerization cofactor of HNF-1 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51937">
        <property type="entry name" value="HNF_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51936">
        <property type="entry name" value="POU_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HNF-p1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="POU-specific atypical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="235"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO32181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="562" mass="61391" checksum="4E1FF534E0499A09" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6F5</accession>
    <name>A0A151N6F5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0000388</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003945">
        <property type="protein sequence ID" value="KYO32321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6F5"/>
    <dbReference type="eggNOG" id="ENOG502QVH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="81"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO32321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="354" mass="39838" checksum="BD2D8EF710217FBF" modified="2016-06-08" version="1">MAENSGKSCPTEIQLVEDQACAGILNEQVPLTPRTQPQVSMRWGNDTSLNEFILVGFSLRPQLRYVLFATFFLIYMFILIANMLIMMAIRLDNALHTPMYFFLFILSISETCYTFVIIPNMLATLLSGGKPISLVGCALQMYFFMSLAETNCGLLAVMGYDRYMAICHPLHYTVLMNPRVCAQLVSVCFFSSFLFSVVTVYLIFQLPYCGPNRIDHFFCDSAPVLQLACTDSSIPESIVFLAAICFIVTALLLILISYIFIINAILKISSAQGQRKAFSTCAAHLTVVVVHYGCAAIIYLRPKSARSLEQDKLITVSYTVFTPLLNPMMYSLRNKEMRLALQRTMTRMFCPQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6T8</accession>
    <name>A0A151N6T8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003911">
        <property type="protein sequence ID" value="KYO32530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6T8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="120" mass="13130" checksum="A07BE20182FCA9A3" modified="2016-06-08" version="1">METSQGLVTQLATEAEGEEEETQTPSDCKQPPAIEEASDLKVGLCDSPREECRQSVAEETETLGEKLKDIPKGAGALLTGAPELSADCLAGQEEFKQEVREDPSLEELWQMAQEQETEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6Z4</accession>
    <name>A0A151N6Z4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6Z4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="10158" checksum="9FC36EBA44E5F407" modified="2016-06-08" version="1">MSQFQSGGEDLEVFDAYSEETLKVFQPINNDTKTVSSCLHYCETGAAGRKKNEVQANVFVLKSCSALLVPEAILGITGKRDQAHLKLPRSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NB87</accession>
    <name>A0A151NB87_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">MFSD1</name>
        <name evidence="27" type="ORF">Y1Q_0024617</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276919.3">
        <property type="nucleotide sequence ID" value="XM_006276857.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NB87"/>
    <dbReference type="STRING" id="8496.A0A151NB87"/>
    <dbReference type="GeneID" id="102576036"/>
    <dbReference type="KEGG" id="amj:102576036"/>
    <dbReference type="CTD" id="64747"/>
    <dbReference type="eggNOG" id="KOG4686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NB87"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17340">
        <property type="entry name" value="MFS_MFSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="26">
        <location>
            <begin position="40"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="520" mass="57369" checksum="70933457D3B43131" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBI6</accession>
    <name>A0A151NBI6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc transporter ZIP4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 39 member 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zrt- and Irt-like protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">SLC39A4</name>
        <name evidence="25" type="ORF">Y1Q_0006764</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003595">
        <property type="protein sequence ID" value="KYO34131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBI6"/>
    <dbReference type="STRING" id="8496.A0A151NBI6"/>
    <dbReference type="eggNOG" id="KOG2693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049406">
        <property type="entry name" value="ZIP4_12_EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041137">
        <property type="entry name" value="ZIP4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF21">
        <property type="entry name" value="ZINC TRANSPORTER ZIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21116">
        <property type="entry name" value="EF-hand_Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18292">
        <property type="entry name" value="ZIP4_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc transporter ZIP4 N-terminal" evidence="23">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc transporter ZIP4/12 EF-hand" evidence="24">
        <location>
            <begin position="144"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF18292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF21116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO34131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="670" mass="72508" checksum="C6F9A2367918973B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEP5</accession>
    <name>A0A151NEP5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Ras-related protein Rab-12</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">RAB12</name>
        <name evidence="27" type="ORF">Y1Q_0007884</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Recycling endosome membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006272328.1">
        <property type="nucleotide sequence ID" value="XM_006272266.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEP5"/>
    <dbReference type="STRING" id="8496.A0A151NEP5"/>
    <dbReference type="GeneID" id="102567791"/>
    <dbReference type="KEGG" id="amj:102567791"/>
    <dbReference type="CTD" id="201475"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8821495at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NEP5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04120">
        <property type="entry name" value="Rab12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000568">
        <property type="entry name" value="Putative Ras-related protein Rab-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041830">
        <property type="entry name" value="Rab12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0072">Autophagy</keyword>
    <keyword evidence="23" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="20" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO35283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="247" mass="27588" checksum="95CD16597848073E" modified="2016-06-08" version="1">MEPGGGLQRRAGAGGPEAGSAGGSPALSGPQSRRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCEVDREITRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDIIRNELSNSILSLQPEPEIPPELPPPRPHVRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NF26</accession>
    <name>A0A151NF26_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NF26"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="10747" checksum="D2D3D8E8CEF7104C" modified="2016-06-08" version="1">MEISYNRKLLHAWVPHILWPIRSNTDQQSWLAQEQVQVSLPSAHRKLEFSNTETSEKQEIELRATELNIQAAHLCMEDQLTVTGKVHSRGCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG05</accession>
    <name>A0A151NG05_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prolactin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PRL</name>
        <name evidence="7" type="ORF">Y1Q_0008026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the somatotropin/prolactin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG05"/>
    <dbReference type="STRING" id="8496.A0A151NG05"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010817">
        <property type="term" value="P:regulation of hormone levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031667">
        <property type="term" value="P:response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10288">
        <property type="entry name" value="prolactin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.10:FF:000003">
        <property type="entry name" value="Prolactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001400">
        <property type="entry name" value="Somatotropin/Prolactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018116">
        <property type="entry name" value="Somatotropin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417:SF5">
        <property type="entry name" value="PROLACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417">
        <property type="entry name" value="SOMATOTROPIN,PROLACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00103">
        <property type="entry name" value="Hormone_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00836">
        <property type="entry name" value="SOMATOTROPIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00266">
        <property type="entry name" value="SOMATOTROPIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00338">
        <property type="entry name" value="SOMATOTROPIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO35455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="236" mass="26819" checksum="996DF294F1B09257" modified="2016-06-08" version="1">MPHMITTMNNKGASLKGVLLVFLLISNMFLTKKSVTSLPICPSGSVNCQVSLGELFDRAVKLSHYIHFLSSEMFNEFDERYAQGRGFITKAVNGCHTASLTTPEDKEQAQQIHHEDLLNLVLGVLRSWNDPLLHLVTEVQRIKEAPNTILWKAAEIEEQNKRLLEGMEKIVGRVQPGDTGNEVYSRWSGLPSLQLADEDSRLFAFYNLLHCLRRDSHKIDNYLKLLKCRLIHDSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGA7</accession>
    <name>A0A151NGA7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0003573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003081">
        <property type="protein sequence ID" value="KYO35842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGA7"/>
    <dbReference type="STRING" id="8496.A0A151NGA7"/>
    <dbReference type="KEGG" id="amj:109283739"/>
    <dbReference type="OrthoDB" id="3175255at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000075">
        <property type="entry name" value="phosphatidylinositol 3-kinase regulatory subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO35842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="17836" checksum="FD2CC8F100DDDD10" modified="2016-06-08" version="1">MASQDGLQYRALYEYQKARDEDLALAPGDLLTVSVAGLPEGDERSPQGWLSGLNERTKERGDFPGTYVEYVGPVRVMAIAPKARPRPVPPAPPGAPAGQLRGPMEAAEHTSLPEQAPVAIRRLLEALEKQGVESEALYRSLPGAAGHPELRQALLTGKSPSRVGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHB9</accession>
    <name>A0A151NHB9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transformer-2 protein homolog beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Splicing factor, arginine/serine-rich 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Transformer-2 protein homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TRA2B</name>
        <name evidence="21" type="ORF">Y1Q_0013088</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHB9"/>
    <dbReference type="STRING" id="8496.A0A151NHB9"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000160">
        <property type="entry name" value="Transformer-2 protein homolog beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO36039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="243" mass="28540" checksum="929CB622655C0759" modified="2016-06-08" version="1">MSDSGEQNYGERESRSASRSGSAHGSGKSGRHTPARSRSKEDSRRSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMSTRRRHIGNRANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVEDAKEAKERANGMELDGRRIRVDFSITKRPHTPTPGIYMGRPTYGSSRRRDYYDRGYDRGYDDRDYYSRSYRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHD8</accession>
    <name>A0A151NHD8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBCC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TBCCD1</name>
        <name evidence="9" type="ORF">Y1Q_0013107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHD8"/>
    <dbReference type="STRING" id="8496.A0A151NHD8"/>
    <dbReference type="eggNOG" id="KOG4416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051661">
        <property type="term" value="P:maintenance of centrosome location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051684">
        <property type="term" value="P:maintenance of Golgi location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="8">
        <location>
            <begin position="255"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO36059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="508" mass="57289" checksum="6B273904D91CECA3" modified="2016-06-08" version="1">MAAYVRARAGAGGWPRLGWPLWRRIACGKLQLPRDLAWLYFERFDALAPRSAAQRLERAEAAAACASDHELEQLRNQFSVDTLQFLLFLYVQQLNKVSLRTSLIGEEWPSPRTRSQSSSLIGKSTCQNKNWNDLEHQAFVLNHLSDLLELLLDPDQLTASSHSTHSSLVSLEAVRALSFLIEGSLNKAKTVHPLHELALWQPFHVKNGYSKISRTFSFPKLEGWLRSCLTVNPFGMSACLKSGKKLAWAQQVEGTTKRAKIACNAHVVPEAYRIVVMSQVYKQTLAKSSETLEGAHVRIHRCNESFIYLLSPLRSVTIEKCSNSTFILGPVQTAIHIHSCDSVKVIAVCHCLSISSTTGCTFHILTPTRPLILLGNQAVTFAPYHTHYPMLEDHMGRTGLATVPNYWDSPMLVCKENSDASVFQLLPSSEFYTFVIPFEMEGDTTETPGGLPYAYQKALRQREQKIQVWQKTVKEAGLTKSQRKQFQQAQSRQRGRILFTNRRSSEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHF4</accession>
    <name>A0A151NHF4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">heme oxygenase (biliverdin-producing)</fullName>
            <ecNumber evidence="2">1.14.14.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HMOX2</name>
        <name evidence="9" type="ORF">Y1Q_0009282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heme oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03003035">
        <property type="protein sequence ID" value="KYO35935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHF4"/>
    <dbReference type="STRING" id="8496.A0A151NHF4"/>
    <dbReference type="eggNOG" id="KOG4480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000001">
        <property type="entry name" value="Heme oxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018207">
        <property type="entry name" value="Haem_oxygenase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF2">
        <property type="entry name" value="HEME OXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00593">
        <property type="entry name" value="HEME_OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO35935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="408" mass="46205" checksum="2DEAA330A362CC5C" modified="2016-06-08" version="1">MRLISTAASDRSCQISNIPVHYYWQGLLEQWVSRGQRWTDWGCAAMLSDVMEASEGADEAEGLHYKEMEEENDVSPTDLSELLKEGTKESHDRAENTQFVKDFLKGRIKKELFKLATVALYFTYSALEEEMDHNKDHPAFAPLYFPLELHRKKELAKDLKFFYGEDWKEKIQCSEAAKCYVDRIHQVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSSGEGIQFYVFENISNAQQFKQFYRARMNALDLDKKTKEKIVEEANAAFKFNMQVFDELDKIGALLTEEAQDGGLPVHDGKGDLHKCPYYATKLGKGDASCLYHIAMAVLKQPTMQFILAACIAMAAGVAAWFFLDWMQAVVKLTGALLQADSKILPAHWPKQNKPPVQQCSISQPFPSHSILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIL3</accession>
    <name>A0A151NIL3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tubulin alpha-8 chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0024323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIL3"/>
    <dbReference type="STRING" id="8496.A0A151NIL3"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="46"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO36638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="229" mass="25929" checksum="BF8014193A1A1B0D" modified="2016-06-08" version="1">MRECISVHVGQAGVQIGNACWELFCLEHGIQPDGTFNDQPYNDDSFATFFRETGTGKHVPRAIMVDLEQTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKDRIDMALDRIRKLFVDWCPTGFKVGINYQPPTITPGGDLAQVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLSALEKDYEEVGTDSFVEENDGEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJ20</accession>
    <name>A0A151NJ20_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RERGL</name>
        <name evidence="7" type="ORF">Y1Q_0024347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014462748.1">
        <property type="nucleotide sequence ID" value="XM_014607262.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJ20"/>
    <dbReference type="STRING" id="8496.A0A151NJ20"/>
    <dbReference type="GeneID" id="102567328"/>
    <dbReference type="KEGG" id="amj:102567328"/>
    <dbReference type="CTD" id="79785"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04146">
        <property type="entry name" value="RERG_RasL11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO36669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="204" mass="23198" checksum="E6CF707FF4569369" modified="2016-06-08" version="1">MSEVKLAVLGSEGAGKSALTVRFLTRRFIGEYASNSECIYTKHLCLDGRQTHLEIYDPCSQPRKGKLSLTNELHWADGFVIVYDISDRTSFAFAKALLYRIRESHLGAFKKVVESPVFLVGNKQDLCHMREVGWNEGQKLAMENKCQFCELSAAEHYQEVMTMFTKALRNITTNFKVKEKRRSSGSKSMAKLINSVFGKRRKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKX0</accession>
    <name>A0A151NKX0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKX0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9756" checksum="12C53F82402BBE86" modified="2016-06-08" version="1">MNANWAQEEERTSPSGAAALETAQRCYLMSWQNSSFDVHMLLKIFFCFQWIYCSSHPKVCLGLLCGCCIFNQDAIFYCLKLDLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLD1</accession>
    <name>A0A151NLD1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AP4S1</name>
        <name evidence="10" type="ORF">Y1Q_0008978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002792">
        <property type="protein sequence ID" value="KYO37295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLD1"/>
    <dbReference type="STRING" id="8496.A0A151NLD1"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14832">
        <property type="entry name" value="AP4_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="9">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO37295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="138" mass="16328" checksum="E5ADF4F25145C7B9" modified="2016-06-08" version="1">MVNKQGQTRLSRYYEHVELHKRTLLEAEVIKNCLSRSKYQCSFIEYKDFKLVYRQYAALFIVVGINETENEMAVYELIHNFVEVLDKYFSRVSELDIMFNLDRVHIILDEMVLNGCIVETNRSRILAPLLVLDKMAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNA0</accession>
    <name>A0A151NNA0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synaptotagmin-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0015540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNA0"/>
    <dbReference type="STRING" id="8496.A0A151NNA0"/>
    <dbReference type="KEGG" id="amj:106737022"/>
    <dbReference type="eggNOG" id="KOG1028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195679at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
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        <property type="entry name" value="BITESIZE, ISOFORM I"/>
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        <property type="entry name" value="SYNAPTOTAGMIN LIKE 2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RabBD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="672"/>
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    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="809"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="77"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="344"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="82"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="130"/>
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            <begin position="150"/>
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            <begin position="411"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00072164"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
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        <source>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO38268.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
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    </evidence>
    <sequence length="976" mass="109258" checksum="D29FC368DAE9F4D4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPC7</accession>
    <name>A0A151NPC7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0007449</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03002443">
        <property type="protein sequence ID" value="KYO38560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="amj:102569613"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosylmethionine synthase"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="130"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="252"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO38560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="395" mass="43648" checksum="FD46A919C1303AC0" modified="2016-06-08" version="1">MNGQLNGFHEAFIEEGSFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVRDTIKHVGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRSEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEDVSLDEMRDALKEKVIKAVVPARYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLIKAGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKTERELLDIVKKNFDLRPGVIVRELDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPF7</accession>
    <name>A0A151NPF7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PRP18 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PRPF18</name>
        <name evidence="10" type="ORF">Y1Q_0023430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273257.1">
        <property type="nucleotide sequence ID" value="XM_006273195.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPF7"/>
    <dbReference type="STRING" id="8496.A0A151NPF7"/>
    <dbReference type="GeneID" id="102560568"/>
    <dbReference type="KEGG" id="amj:102560568"/>
    <dbReference type="CTD" id="8559"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NPF7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000002">
        <property type="entry name" value="Pre-mRNA processing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.110:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor 18 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="79"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO38736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="342" mass="39664" checksum="9D5AEC075CF9E6A9" modified="2016-06-08" version="1">MDILRAEITRKRRLLEEKELVGENKKHFKRSELVKKEEEAYLQRCGYKVQQTEEEEKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILAPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEAGEDDSQNDLKVHEENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRGVQGKLSSATQKQTESYLRPLFRKLRKRTLPADIKESITDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPSKCVEYNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPN7</accession>
    <name>A0A151NPN7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Muskelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MKLN1</name>
        <name evidence="14" type="ORF">Y1Q_0023477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer; may form higher oligomers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8. Interacts with GABRA1. Interacts with the C-terminal tail of PTGER3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014462973.1">
        <property type="nucleotide sequence ID" value="XM_014607487.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPN7"/>
    <dbReference type="STRING" id="8496.A0A151NPN7"/>
    <dbReference type="GeneID" id="102564339"/>
    <dbReference type="KEGG" id="amj:102564339"/>
    <dbReference type="CTD" id="4289"/>
    <dbReference type="eggNOG" id="KOG2437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10052615at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000018">
        <property type="entry name" value="Muskelin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000035">
        <property type="entry name" value="Muskelin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000066">
        <property type="entry name" value="Muskelin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="CTLH" evidence="13">
        <location>
            <begin position="207"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO38802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="736" mass="84676" checksum="986B7DEC0449299F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSP3</accession>
    <name>A0A151NSP3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0006746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSP3"/>
    <dbReference type="eggNOG" id="ENOG502SHE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="16"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO39882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="286" mass="32029" checksum="F64ADAD3AE247EB6" modified="2016-06-08" version="1">MLFGLFLIMHLVTLGGHMTIVLVTLVDPALHIPMYFFLCNLSVIEICYTLVIVPKMLANFLAGNHRISLVGCATQMCFFIALGGAECFLLAAMAYDRYVAICNPLRYTLIMSRPLCLQLLAMACTSGFLLSLGLTALIFHLPFCHSHEINHFFCDIPPVLELACSDTHADEVAVFLVCMLILMVPFLMILASYVLIVASILRIHSAQERRKAFSTCAAHLVVAVLHYGCAIFIYIRPKASYALEQDKVVSLIYTNVTPMLYPAIYSLRNREVQGALRKVWDRIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTQ9</accession>
    <name>A0A151NTQ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 150A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane protein 150</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMEM150A</name>
        <name evidence="12" type="ORF">Y1Q_0004402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001979">
        <property type="protein sequence ID" value="KYO40292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014466269.1">
        <property type="nucleotide sequence ID" value="XM_014610783.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTQ9"/>
    <dbReference type="GeneID" id="106737161"/>
    <dbReference type="KEGG" id="amj:106737161"/>
    <dbReference type="CTD" id="129303"/>
    <dbReference type="eggNOG" id="KOG4320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9925752at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 150A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO40292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="271" mass="28799" checksum="6B37DB1891CBD7A9" modified="2016-06-08" version="1">MTAWIILPISLSAFSITGIWIVYAMAVMNHHVCPVENWSYNESCPTEPAQPGTPKTCCTLEDIPLISKCGTYPPESCLFSLIGNVGAFMVVVICVLRYGQLLEQSQRSWINTTALVTGCTNAAGLVMVGNFQVDHAKSLHYIGAGIAFPAGLLFVCLQCVLTYHMAASALDLGVAHARAALTALALVTLVLSGAFFIHESPVLQHVAALCEWAFVLAILIFYGTLSYEFGAVSSETLVAALQGAHARGCKSPGSSSTSTHLNCNPESIAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU17</accession>
    <name>A0A151NU17_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0006592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002098">
        <property type="protein sequence ID" value="KYO40059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NU17"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="193" mass="20259" checksum="902A6E5599B5EF34" modified="2016-06-08" version="1">MMSTAHPASKDVGEAALVVNKTLQNDGEIAFMVDECLDVLRWAGDGDVDAVHGSQVVGEAYAEEASNHILRVDEVDAVVGRDILDDQAHLPECLPSCVLAHTELVGDVVETAEGGQLHDSDRHLLLQTHVEGLDPPFVIPGAQANPFPPVAAGGANPELDLVGLEVVLEHPGVHGILDGLVVVGHVKVVVMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUT1</accession>
    <name>A0A151NUT1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0015386</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001884">
        <property type="protein sequence ID" value="KYO40682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUT1"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000321">
        <property type="entry name" value="myeloid zinc finger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000380">
        <property type="entry name" value="zinc finger protein 2 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001011">
        <property type="entry name" value="Zinc finger protein 793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO40682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="390" mass="44256" checksum="7B0DF11CB4456F25" modified="2016-06-08" version="1">MAQESSEAPKAEGECGSEPGEKPHQCSECGKKFHLSSHLAQHRLIHTGEKPHQCLECGKSFRRLSTLTQHRLIHLPEKPYQCSECGKRFHLSFLLTQHQLIHSGEKPHQCSVCGKRFSLSSYLTKHQHIHTGEKPHHCSDCGKSFTQSSNLTRHRLIHTGEKPHQCSECGKSFRQTSDLAQHWLIHTREKPHQCLECGKSFTRSSDLSKHRLIHTAEKPHQCSGCGKSFTRSSHLNQHQLIHMGKKPHQCSECGKSFTRSSRLAQHQHIHTGEKPHRCSECGKSFTRSSSLTQHWLIHTGEKPHQCSECGKSFRQLCSLTQHQLIHTQEKPHHCSACGKSFTQCSSLTQHQLIHTGKKPHQCSECGKSFTRSSTLTKHKLLHTGEKPHQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NV58</accession>
    <name>A0A151NV58_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001975">
        <property type="protein sequence ID" value="KYO40305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NV58"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="173" mass="18462" checksum="C853F44930281C4C" modified="2016-06-08" version="1">MLLFSAWMPTASCPGKLKMDAAPAPQAKVLELQSRRVVEVLSPVLEPSCVDRKLLGLQLSHEMALEHPDPALPHGSLLYQRHSLPDCIVPARKTLHTPASLRSPRRCSDAGWFSTRPGDSLSAAWHPVGPVPMAMGGGRLVVRHERPPAQGGIGNMADAAVCSGQGKQKGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NV63</accession>
    <name>A0A151NV63_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">WD repeat-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Bromodomain and WD repeat-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">WDR11</name>
        <name evidence="21" type="ORF">Y1Q_0009514</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NV63"/>
    <dbReference type="STRING" id="8496.A0A151NV63"/>
    <dbReference type="eggNOG" id="KOG1912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000204">
        <property type="entry name" value="WD repeat domain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000309">
        <property type="entry name" value="WD repeat domain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000210">
        <property type="entry name" value="WD repeat-containing protein 11 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057852">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057854">
        <property type="entry name" value="TPR_WDR11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23751">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23753">
        <property type="entry name" value="TPR_WDR11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR11 first beta-propeller" evidence="18">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="19">
        <location>
            <begin position="484"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 TPR" evidence="20">
        <location>
            <begin position="980"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO40469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1222" mass="136462" checksum="7FFB5F1859087936" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX82</accession>
    <name>A0A151NX82_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Transcription factor Dp-1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TFDP1</name>
        <name evidence="21" type="ORF">Y1Q_0006180</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX82"/>
    <dbReference type="STRING" id="8496.A0A151NX82"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000047">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.80:FF:000001">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045158">
        <property type="entry name" value="KEA4/5/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254">
        <property type="entry name" value="POTASSIUM/PROTON ANTIPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254:SF14">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="13 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="20">
        <location>
            <begin position="661"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="19">
        <location>
            <begin position="751"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="630"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="922"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="946"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO41343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="962" mass="106845" checksum="BFC1E2FD2F23B5F2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYR7</accession>
    <name>A0A151NYR7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatase and actin regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PHACTR3</name>
        <name evidence="8" type="ORF">Y1Q_0002668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Binds PPP1CA and actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340023.1">
        <property type="nucleotide sequence ID" value="XM_019484478.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYR7"/>
    <dbReference type="STRING" id="8496.A0A151NYR7"/>
    <dbReference type="GeneID" id="102577083"/>
    <dbReference type="CTD" id="116154"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF7">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU301113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO42016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="583" mass="65617" checksum="1E628BA0F2C098F3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P043</accession>
    <name>A0A151P043_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001423">
        <property type="protein sequence ID" value="KYO42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P043"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="106" mass="11371" checksum="AC0AC9A3D90BC0FC" modified="2016-06-08" version="1">MGEISVIETDSRTPKTDPGTVAYPQQTASEPQAESLGVADNLNPKDSAEGAGMDSYTTPVRHFVPALPQRPDKCLPRKCYCSDSSEEGEIKESSCLSQAFPEMFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0F2</accession>
    <name>A0A151P0F2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase RNF126</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING finger protein 126</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RNF126</name>
        <name evidence="22" type="ORF">Y1Q_0000284</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 24">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with CCDC50, EGFR, FLT3 and SCAMP3. Interacts with BAG6 (via ubiquitin-like domain); required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts with CDKN1A. Interacts with AICDA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03001382">
        <property type="protein sequence ID" value="KYO42612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014455145.1">
        <property type="nucleotide sequence ID" value="XM_014599659.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0F2"/>
    <dbReference type="STRING" id="8496.A0A151P0F2"/>
    <dbReference type="GeneID" id="102569414"/>
    <dbReference type="KEGG" id="amj:102569414"/>
    <dbReference type="CTD" id="55658"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16801">
        <property type="entry name" value="RING-H2_RNF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000253">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039571">
        <property type="entry name" value="RNF126_RING-H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF21">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO42612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="313" mass="34341" checksum="3472599E5B31F29B" modified="2016-06-08" version="1">MAEASPQPGRYFCHCCSAEIAPRLPDYICPRCESGFIEELPEEPRNADNGSSSSTATSDQSRHPFENVDQHLFTLPQGYGQFAFGIFDDSFEFPAFGSNVQSEDNRDTENRREREHQSRHRYGARQPRARLTARRAAGRHEGVPTLEGIIQQLVNGIIAPTTIPNLGIGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTTQITQEHVDSGLECPVCKEDYTVGENVRQLPCNHLFHNGCIVPWLEQHDTCPVCRKSLSGQNTATNPPGLTGMNFSSSSSSSSSSSPSNENSSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0Q2</accession>
    <name>A0A151P0Q2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vesicle-associated membrane protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0022375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001358">
        <property type="protein sequence ID" value="KYO42707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0Q2"/>
    <dbReference type="STRING" id="8496.A0A151P0Q2"/>
    <dbReference type="KEGG" id="amj:106738081"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15868">
        <property type="entry name" value="R-SNARE_VAMP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO42707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="102" mass="11726" checksum="2C8ED99CB89E95EB" modified="2016-06-08" version="1">MPVMENNKNTTDTISTLQIQVDDVKNVMTKNIDKVLQREEKLSELVDRTDDLQTAADAFQKTSTKISRKMWWKNFKMVILIVVIFLIILTFIILLATGVIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2B4</accession>
    <name>A0A151P2B4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Centrosomal protein of isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CEP57</name>
        <name evidence="11" type="ORF">Y1Q_0012930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the translokin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001255">
        <property type="protein sequence ID" value="KYO43050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2B4"/>
    <dbReference type="STRING" id="8496.A0A151P2B4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000003">
        <property type="entry name" value="Centrosomal protein of 57 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025913">
        <property type="entry name" value="Cep57_CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF11">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 57 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14073">
        <property type="entry name" value="Cep57_CLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome localisation" evidence="10">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome localisation" evidence="10">
        <location>
            <begin position="166"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="9">
        <location>
            <begin position="392"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="166"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="434"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO43050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="543" mass="61189" checksum="2775130AD3EE5BF0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3P9</accession>
    <name>A0A151P3P9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3P9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="139" mass="15454" checksum="D27C2A30883E96FF" modified="2016-06-08" version="1">MCGITANLINHSLHYKGANVPMFTISHSLDQEKYFYLYTWVNPGTGNSGLQEMPPPSPSFSSSPLTLLPWSQQATAASVGDVLEPLKQATEGFATQSDLRIPRGLVWSMVHMESQGFLRTNCPERVNQTVPQKHSYDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P678</accession>
    <name>A0A151P678_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-globin A subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Hemoglobin subunit alpha-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HBAA</name>
        <name evidence="10" type="synonym">HBA</name>
        <name evidence="9" type="ORF">Y1Q_0005925</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Alligator mississippiensis genome assembly.</title>
            <authorList>
                <person name="Rice E.S."/>
                <person name="O'Connell B.L."/>
                <person name="Putnam N."/>
                <person name="Sugnet C."/>
                <person name="Stites J."/>
                <person name="Kern C."/>
                <person name="Gresham C."/>
                <person name="Mccarthy F."/>
                <person name="Schmidt C.J."/>
                <person name="Green R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2020" name="Am. J. Physiol. Regul. Integr. Comp. Physiol." volume="0" first="0" last="0">
            <title>Structure and function of crocodilian hemoglobins and allosteric regulation by chloride, ATP and CO2.</title>
            <authorList>
                <person name="Fago A."/>
                <person name="Natarajan C."/>
                <person name="Pettinati M."/>
                <person name="Hoffmann F.G."/>
                <person name="Wang T."/>
                <person name="Weber R.E."/>
                <person name="Drusin S.I."/>
                <person name="Issoglio F.M."/>
                <person name="Marti M.A."/>
                <person name="Estrin D.A."/>
                <person name="Storz J.F."/>
            </authorList>
            <dbReference type="PubMed" id="32022587"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000725">
        <property type="protein sequence ID" value="KYO44566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN905608">
        <property type="protein sequence ID" value="QHX99522.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P678"/>
    <dbReference type="SMR" id="A0A151P678"/>
    <dbReference type="STRING" id="8496.A0A151P678"/>
    <dbReference type="GeneID" id="102559387"/>
    <dbReference type="KEGG" id="amj:102559387"/>
    <dbReference type="OrthoDB" id="8751793at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031838">
        <property type="term" value="C:haptoglobin-hemoglobin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005833">
        <property type="term" value="C:hemoglobin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031720">
        <property type="term" value="F:haptoglobin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043177">
        <property type="term" value="F:organic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08927">
        <property type="entry name" value="Hb-alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000002">
        <property type="entry name" value="Hemoglobin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002338">
        <property type="entry name" value="Hemoglobin_a-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050056">
        <property type="entry name" value="Hemoglobin_oxygen_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002339">
        <property type="entry name" value="Hemoglobin_pi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11442">
        <property type="entry name" value="HEMOGLOBIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11442:SF48">
        <property type="entry name" value="HEMOGLOBIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00612">
        <property type="entry name" value="ALPHAHAEM"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00815">
        <property type="entry name" value="PIHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO44566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QHX99522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="142" mass="15865" checksum="D5995EF90A6B45E9" modified="2016-06-08" version="1">MVLSMEDKSNVKAIWGKASGHLEEYGAEALERMFCAYPQTKIYFPHFDMSHNSAQIRAHGKKVFSALHEAVNHIDDLPGALCRLSELHAHSLRVDPVNFKFLAHCVLVVFAIHHPSALSPEIHASLDKFLCAVSAVLTSKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7F8</accession>
    <name>A0A151P7F8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM220</name>
        <name evidence="2" type="ORF">Y1Q_0007321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7F8"/>
    <dbReference type="eggNOG" id="ENOG502S0TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029377">
        <property type="entry name" value="TMEM220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34262">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34262:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15071">
        <property type="entry name" value="TMEM220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="143" mass="15710" checksum="CE1B33D5E80333DA" modified="2016-06-08" version="1">MQTVSLIPVNDPDAGLWIVVYSVPAALTLLVGYSPSITDNVVWRTLSDLHSVACVMGTIALGCSLFAYTQANILHEEEGRELSGLVIIVVWMSLCRSSAKNPFGGIRLLVAISLSLVPFVMWLYIYVNKEVRSSWPTHCKTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7T7</accession>
    <name>A0A151P7T7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0007401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7T7"/>
    <dbReference type="STRING" id="8496.A0A151P7T7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="85"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO45108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="208" mass="22993" checksum="63F3937A18BD49EC" modified="2016-06-08" version="1">MQTQTRGPELLLLRERCRQGRPDRHSARSSTAPAVAGGRFAEQDGHLHRVGIAGQSPVIAQVTSQLCNPSSTPHASQDRRRKCSQAFPDGGKVFAKLDLTQAYQQLIADDKAAEAQTIITHWGASRVRGLQFGISVAPGIFQRFMEKMLAGITGVVPYFDNVLIMGLSREKLTERLREVLQRFDKAGIRVKREMSTGSFQYQLSGISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P818</accession>
    <name>A0A151P818_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P818"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="156" mass="17681" checksum="0A536744E094E6C1" modified="2016-06-08" version="1">MDERMSKNKMIRDGDNTMVEIIKQAVQNILEWQCKASDLSRGDSLEVYTQAGKIQTGDTGSKTQQQGGKSWMTQGIVIINPQEITQGFRNTCSTSSPLKIHKLNFSLGISWHKSKGVTRAWSQRMILAHCSQRPTKPDLKICKRMINNYTKEANLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P825</accession>
    <name>A0A151P825_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">M-phase phosphoprotein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MPHOSPH8</name>
        <name evidence="8" type="ORF">Y1Q_0022971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000640">
        <property type="protein sequence ID" value="KYO44895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P825"/>
    <dbReference type="STRING" id="8496.A0A151P825"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18633">
        <property type="entry name" value="CD_MMP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000022">
        <property type="entry name" value="M-phase phosphoprotein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF47">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO44895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="790" mass="89221" checksum="1E7B5F7BBC09CF03" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8N8</accession>
    <name>A0A151P8N8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TTLL1</name>
        <name evidence="18" type="ORF">Y1Q_0023059</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000602">
        <property type="protein sequence ID" value="KYO45340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8N8"/>
    <dbReference type="STRING" id="8496.A0A151P8N8"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO45340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="385" mass="44259" checksum="9B6F81731EFBB681" modified="2016-06-08" version="1">MSIQTIRNVFSVETGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAEKDENGKYIYLDFVPVTFMLPADYNLFVEEFRKNPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSSKEAYVISLYINNPLLIGGKKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGDDYNHIHGGKWTVSNLHLYLESTRGKEVTNKLFNEIHWIIVQSLKAVSPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEALGSYEVLYDEEMAQSGGPDRDLRSRSGQSIGIKGNRARDSGKPVLTTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9C3</accession>
    <name>A0A151P9C3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TRMT44</name>
        <name evidence="13" type="ORF">Y1Q_0021370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059577525.1">
        <property type="nucleotide sequence ID" value="XM_059721542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9C3"/>
    <dbReference type="STRING" id="8496.A0A151P9C3"/>
    <dbReference type="GeneID" id="102575928"/>
    <dbReference type="CTD" id="152992"/>
    <dbReference type="eggNOG" id="KOG3790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO45697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="496" mass="57223" checksum="CC6EE6B958E9B2B4" modified="2016-06-08" version="1">MNESWVSDGIVYPKTTWLGNELLSKLAKWSLEQKQSEFKSTLSLISVAKYSKIYQELKEKYKEMVKVWPEVTDPEKFVYEDVAIAAYLLILWEEERAEKGLSKKQSFVDLGCGNGLLVHILSREGHPGKGIDVRRRKIWDMYGPQTHLEECAVKPCGSYLFPDVDWLIGNHSDELTPWIPVIAARSSYSCCYFVLPCCFFDFHGKYNRRQSKKTQYREYLDFVTQVGCACGFNVEEDSLRIPSTKRVCLIGKSRTYPSTQESLIDKQRTQYINSRQSCIVIPQDRRAGSNYCDNHNIKKSAVDKAADLEFPENETKIDDSGIWLSGFRPREKVEQVRNCATLPRDFVDDVVLDVANLLLSATQEKPCNMPDGSLNTWNRGDSLPLREVAEHLDKETLKRLKSEYGGLQTLLKNNHQVFEVINGRVQIRDWREKKQAKKTPPEIKRRLSAEAFKTRLCWFFIHHPDGCSLTSESCPYAHGTEELRQSQILKKIKHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9M7</accession>
    <name>A0A151P9M7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clarin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CLRN2</name>
        <name evidence="7" type="ORF">Y1Q_0021445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267287.1">
        <property type="nucleotide sequence ID" value="XM_006267225.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9M7"/>
    <dbReference type="GeneID" id="102558866"/>
    <dbReference type="KEGG" id="amj:102558866"/>
    <dbReference type="CTD" id="645104"/>
    <dbReference type="eggNOG" id="ENOG502QUCR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10012538at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF5">
        <property type="entry name" value="CLARIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25807">
        <property type="entry name" value="Clarin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO45801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="231" mass="25396" checksum="021CE9E6F2EE13EF" modified="2016-06-08" version="1">MPGCFKKTLFALASAMSFVSFILIVVAMGTQKWITGKILCKTGADLVNATDPELVKFTGDIYYGLFRGGKVRQCGLGGRRSKFTLFPHLVKKLNTGLHVMIIIFLCVAISFALISFGFCILNIIQVPYRAIKGPAGICLWNLLAGGFTALAVASFIAAVKLHHLTERIANFQEIFQFLVLEEQYEGSFWLCVASATAHGVNLLLIALSAIRFPEFKTKTEEANVTAEDIMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAV8</accession>
    <name>A0A151PAV8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAV8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10406" checksum="8C9C88ED5BD2D1BB" modified="2016-06-08" version="1">MKCISRAGLEDYIFKNKYLNHTEINTVFQILQRILLRPGDQKMHKWSLKIAESWGVPGNRGGRSVTGGYDSDHFKSELLFIQRNANVASIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBA1</accession>
    <name>A0A151PBA1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium/bile acid cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SLC10A7</name>
        <name evidence="18" type="ORF">Y1Q_0021863</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Does not show transport activity towards bile acids or steroid sulfates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBA1"/>
    <dbReference type="STRING" id="8496.A0A151PBA1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000008">
        <property type="entry name" value="Sodium/bile acid cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0915">Sodium</keyword>
    <keyword evidence="15 16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="9 16" id="KW-0769">Symport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR026166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO46361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="403" mass="45106" checksum="7CBC49D03D9AF7C8" modified="2016-06-08" version="1">MGLPERLRKEWFLLGIVLAIAAAKLQPAVGAKGGPLKPEITITYIAVSAIFFNSGLSLKTEWMRHWQPEIMLRILHCSELTSALMHVKLHLFVQIFTLVFFPTAIWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSSVPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKKPPFGAISSCVLLMIIYTTFCDTFANPNIDLDKFSLIIVVFIIFSVQLSFMFVTFLFSTRNNSGFTPADTVAIIFCSTHKSLTLGIPMLKIVFAGYEHLSLISVPLLIYHPAQILLGSLLVPTIKSWMISRQKALKLTRQPKAPVKAWDQAQREHEFWMTGLNPRENSCTQFFFPFIGCVYTEQSIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDS9</accession>
    <name>A0A151PDS9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ALG13L</name>
        <name evidence="9" type="ORF">Y1Q_0019975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03000474">
        <property type="protein sequence ID" value="KYO47267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDS9"/>
    <dbReference type="STRING" id="8496.A0A151PDS9"/>
    <dbReference type="GeneID" id="102562578"/>
    <dbReference type="KEGG" id="amj:102562578"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO47267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="187" mass="19840" checksum="E4BFADB83B3518E0" modified="2016-06-08" version="1">MAVSSAAPAAGGCPLEARPAPGATKSAFVTVGTTCFDELIAAVSAAPCLRVLRGLGYGRLVLQIGRGTRAPRPVRAPDFALEVFRFKDSLAEDLRQADLVISHAGAGSCLETLGEGKPLVVVINETLMDNHQLELARQLRRDGHLVYCTCSTLAETLQSVDLSLLKPFPPGRPEKFAAFLDDVLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEB5</accession>
    <name>A0A151PEB5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[heparan sulfate]-glucosamine N-sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0001232</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.8" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEB5"/>
    <dbReference type="STRING" id="8496.A0A151PEB5"/>
    <dbReference type="eggNOG" id="KOG3703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="UniPathway" id="UPA00862"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015016">
        <property type="term" value="F:heparan sulfate N-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030210">
        <property type="term" value="P:heparin proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000176">
        <property type="entry name" value="bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056793">
        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF29">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25119">
        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="21">
        <location>
            <begin position="14"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulphate-N-deacetylase deacetylase" evidence="20">
        <location>
            <begin position="240"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="19">
        <location>
            <begin position="534"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="16">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="762"/>
            <end position="766"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF25119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO47437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="811" mass="93554" checksum="E9B985DE0CAFD904" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PF19</accession>
    <name>A0A151PF19_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PF19"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO47598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="8219" checksum="541C6608B9BD8982" modified="2016-06-08" version="1">MLHRKTGITKLCQCDLVEKSLLGPRAGRGLTLIRTARPFCQECLEEETVRQTYLGDPHSIQADPRRLIPSASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFD8</accession>
    <name>A0A151PFD8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LRRC10</name>
        <name evidence="4" type="ORF">Y1Q_0019828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFD8"/>
    <dbReference type="STRING" id="8496.A0A151PFD8"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF37">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO47753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="256" mass="28422" checksum="BA02B21AC4042935" modified="2016-06-08" version="1">MPADKVVELSGRQLRRLPLRVCAFGALVKLYLSDNRLSQLPPELERLQHLQLLALDFNEFRALPGAVCALRRLCTLYLGNNRLRDLPRDLCRLQNLRTLWLDANRLSRLPAAVCDLRLLRALHAGSNALRALPARLRTLRRLRSIWLSDNQLPAFPPVLLRMPLLEVIDVDRNAIRAFPSLAHLPALKLVIYDHNPCRNAPRVRPGVRRVGRWADDSPEPARHVLPSPEPAAPQPRPCAGGGGGVAVATTAAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFI2</accession>
    <name>A0A151PFI2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFI2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="8742" checksum="8DE03FD8F22B1FBF" modified="2016-06-08" version="1">MQFWKTPGLCFHVPAACKTPSDKITATWLGENKKTEQLSHMWLPRHKRELLGACTLSPRVAPGTRLGLQLELLSSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFK8</accession>
    <name>A0A151PFK8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">A-type voltage-gated potassium channel KCND2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Potassium voltage-gated channel subfamily D member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Voltage-gated potassium channel subunit Kv4.2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">KCND3</name>
        <name evidence="26" type="ORF">Y1Q_0019678</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFK8"/>
    <dbReference type="STRING" id="8496.A0A151PFK8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905030">
        <property type="term" value="F:voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18418">
        <property type="entry name" value="BTB_POZ_KCND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000073">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000016">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000152">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004055">
        <property type="entry name" value="K_chnl_volt-dep_Kv4.2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF265">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01517">
        <property type="entry name" value="KV42CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="25">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO47565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="346" mass="39822" checksum="2625773228E1C6CB" modified="2016-06-08" version="1">MPAAPRQERKRSQDSLIVLNVSGIQFQTWLDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRQECISAYDEELAFFGIIPEIIGDCCYEEYKDRRRENAERLQDDADQEHAAENSLPSMTARQRMWRAFENPHTSTLALVFYYVTGFFIAISVIANVVETVPCGISPGRIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLVAAPSRYKFVRSVMSIIDVVAIMPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSATKFTSIPAAFWYTIVTMTTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PH21</accession>
    <name>A0A151PH21_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ATP6V0D2</name>
        <name evidence="6" type="ORF">Y1Q_0024694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000227">
        <property type="protein sequence ID" value="KYO48330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006269774.1">
        <property type="nucleotide sequence ID" value="XM_006269712.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PH21"/>
    <dbReference type="STRING" id="8496.A0A151PH21"/>
    <dbReference type="GeneID" id="102566859"/>
    <dbReference type="KEGG" id="amj:102566859"/>
    <dbReference type="CTD" id="245972"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PH21"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO48330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="351" mass="40426" checksum="35CDAD0B02F687C6" modified="2016-06-08" version="1">MQGYSEFYFNVDHGYLEGLVRGFKAGILRNADYVNLAQCETLEDLKLHLQTTDYGNFLANETGPLTVSTIDDKLKDKLLTEFHYFRNHAFEPLATFLNFITYSYMIDNVILLITGTLHQRPIAELVPKCHPLGSFEQMEAVSIAQTPSELFNAILVDTPLADFFQDCLSENDLDEMNIEIMRNKLYKSYLEAFFKFCEKQGGTTAEIMCPILEFEADRRAFIITINSFGTELSKDDREKLYPTCGKLYPEGIHLLANADDYEQVKCVADYYAEYKALFEGVGNGTGEKTLEDAFFEHEVKLNVLAFNNQFHFGVFYAYIKLKEQESRNVVWIAECISQRHRTKINNYIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIE1</accession>
    <name>A0A151PIE1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">UBX domain-containing protein 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">UBXN2A</name>
        <name evidence="18" type="ORF">Y1Q_0020229</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons. Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation. Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9. Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Part of a complex composed of STUB1/CHIP, VCP/p97, CHRNA3, and UBXN2A that modulates the ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of CHRNA3. Within the complex UBXN2A acts as a scaffold protein required for the interaction of CHRNA3 with VCP/p97, this interaction also inhibits CHRNA3 ubiquitination by STUB1/CHIP and subsequently ERAD. Interacts (via SEP domain) with CHRNA3 and interacts (via UBX domain) with VCP/P97; these interactions are required for the interaction of CHRNA3 with the STUB1-VCP-UBXN2A complex. Interacts with HSPA9/MOT-2 (via SBD domain); the interaction inhibits HSPA9/MOT-2 interaction with and degradation of p53, thereby promotes p53 translocation to the nucleus. Interacts with RICTOR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000178">
        <property type="protein sequence ID" value="KYO48881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIE1"/>
    <dbReference type="STRING" id="8496.A0A151PIE1"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17160">
        <property type="entry name" value="UBX_UBXN2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000164">
        <property type="entry name" value="UBX domain-containing protein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000004">
        <property type="entry name" value="UBX domain-containing protein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF16">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SEP" evidence="17">
        <location>
            <begin position="102"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="16">
        <location>
            <begin position="213"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO48881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="302" mass="34524" checksum="9CA4360016E70B55" modified="2016-06-08" version="1">MFSAWRLSHQKRAGIRLGFEVLVRVSGCTFEEAWGGQEAWQSIRMKEVDNIETLSEEWMCKQGAEDQLNGTEQSHKCFVDNLFEEARKIGAICMPPAKVNKQADIIIKLWKNGFTVNDGNLRSYTDVANQQFLDSIKKGELPFELQKNFDEEEVDVKVEDKKDEVYMSRKPVFHPFSGHGYRLGSATPRIISKGRNDHGDIQKRALPSVPLSDSEPITNVQIWLADGERIVQKFNVSHRISHVRDFIMQYQGVEGSVPFTLTTSLPFLELQDETLSLEEANLQNAVIVQRRQKTTEPFQSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIU4</accession>
    <name>A0A151PIU4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RGM domain family member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RGMB</name>
        <name evidence="15" type="ORF">Y1Q_0004128</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the repulsive guidance molecule (RGM) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019339499.1">
        <property type="nucleotide sequence ID" value="XM_019483954.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIU4"/>
    <dbReference type="STRING" id="8496.A0A151PIU4"/>
    <dbReference type="GeneID" id="102573202"/>
    <dbReference type="CTD" id="285704"/>
    <dbReference type="eggNOG" id="ENOG502QSTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10013795at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.10:FF:000001">
        <property type="entry name" value="Repulsive guidance molecule BMP co-receptor a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040287">
        <property type="entry name" value="RGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009496">
        <property type="entry name" value="RGM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010536">
        <property type="entry name" value="RGM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428:SF5">
        <property type="entry name" value="REPULSIVE GUIDANCE MOLECULE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428">
        <property type="entry name" value="RGM DOMAIN FAMILY MEMBER DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06534">
        <property type="entry name" value="RGM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06535">
        <property type="entry name" value="RGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007587084" evidence="12">
        <location>
            <begin position="45"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule N-terminal" evidence="14">
        <location>
            <begin position="50"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule C-terminal" evidence="13">
        <location>
            <begin position="156"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO48754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="433" mass="47277" checksum="4FCF499EADB427D6" modified="2016-06-08" version="1">MGEAAAAPAVAIAVAEPRRRPRPPARAALLLLLGLGLLLRTGDCQLQTPCRIQKCTTDFVSLTSHLNPAIDGFDLEFCKALRAYAACTYRNSKVCRGNLVYHSAVLGISDLMSQRNCSKDGPTSSTNPEVTHDPCNYSSRTGAREHRGGEQTPPVYLFCGLFGDPHLRTFKDHFQTCKVEGAWPLIDNNYLSVQVTNVPVVPGSSATATNKITIIFKSYQDCTDQKVYQAVTDDLPAAFVDGTTSGGDGDTKSLRIVEKVSGKYVEMHARYIGTTVFVRQHGRYLTLAIRMPEELAMAYEESQDLQLCVNGCPSSERIDDSGHLPLPVMGQLPPHAGSTQPRSVYTLESATTKCHEKMLVKDIYFYSCVFDLLTTGDANFTAAAHSALQDVEVLHPRKERWHIFPNNGTGGFVKGSKLSVSLGLVCLILVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZE7</accession>
    <name>A0A151LZE7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Partner of Y14 and mago</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PYM1</name>
        <name evidence="6" type="ORF">Y1Q_0015394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006924">
        <property type="protein sequence ID" value="KYO17624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267757.1">
        <property type="nucleotide sequence ID" value="XM_006267695.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZE7"/>
    <dbReference type="STRING" id="8496.A0A151LZE7"/>
    <dbReference type="GeneID" id="102558034"/>
    <dbReference type="KEGG" id="amj:102558034"/>
    <dbReference type="CTD" id="84305"/>
    <dbReference type="eggNOG" id="KOG4325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="PhylomeDB" id="A0A151LZE7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO17624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="210" mass="23438" checksum="878FC05D5659862F" modified="2016-06-08" version="1">MATPYVTDETGKYIASTQRPDGTWRKQRRVKEGYVPQEEVPVYENKYVKFFKSKPELPPGLSPEANAQPGRPAPRAESGEVGLSKTAKRNLKRKEKRKQQQEKGEKDTDELIQVLEKTTLSGGGAGDRGLPAPPQPLACGAKAPGDGEALAAVAEKTKKIKNLRKKLRQVEELQQRVDSGEIKQPSREQLEKLARRKALEEELEDLELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M009</accession>
    <name>A0A151M009_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rap guanine nucleotide exchange factor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M009"/>
    <dbReference type="STRING" id="8496.A0A151M009"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF41">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO17844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="169" mass="19139" checksum="042E9C2FB9FF74CF" modified="2016-06-08" version="1">MVAAHGSHPSSSGEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLQQICLCGYYENLEKGITLFRQGDIGTNWYAVLTGSLDVKVSDTSNHQDAVTICTLGIGTAFGESILDNTPRHATIVTREYSELLRIEQKDFKTLWEEPIKSAKQGCLYFIQQEIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0X9</accession>
    <name>A0A151M0X9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0X9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="107" mass="12321" checksum="3F638DA8403E134E" modified="2016-06-08" version="1">MHVVSFSLYVPLASPLYDPDHGEQGSRGAKPSYVGVDKIPSARFMVIHTSSTLYYTEGFFSLSLDTTGPRHQQISHQTLNQRHNRMEYQLHHPQLGQEESWLYQMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M149</accession>
    <name>A0A151M149_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0011770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M149"/>
    <dbReference type="STRING" id="8496.A0A151M149"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13415">
        <property type="entry name" value="Beta-prop_FBX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO18212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="386" mass="43082" checksum="98A982760F075157" modified="2016-06-08" version="1">MKGKTAECVWKPIPQSKSSPCDRYKHACCICKGFVYLHGGRHTTNLSDFWRYSIESNEWEMLHGSGDGPEELEEHSMVAYQGMLCVFGGMLDSAFTQTKAPLWMYDIDSARWTECRHTEAETESTAPANRKGHSAVVYSSSMYVYGGYFDIKGISQEFWALSFDTGEWSCISALSYDTGPGPRHGHSAVVYSTGMYLFGGLMGLSEQKDLWKWDFTSRNWSSIRTSQGPPKVVGHSSVVFRDSMLIFGGGISSSRPQSSLWKYHFSSQTWSKLAHTAKVAESHSLACAEATHCNCTLPALHRFSTHVSMQDVQTLSMGHLNISYTNKECTFLNDELQPPTSLCKLCGLLRLPRPKQESSGKCTRGSWEPTGRDQALTELSFAEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M301</accession>
    <name>A0A151M301_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptor family C group 6 member A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GPRC6A</name>
        <name evidence="19" type="ORF">Y1Q_0018876</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M301"/>
    <dbReference type="STRING" id="8496.A0A151M301"/>
    <dbReference type="eggNOG" id="KOG1056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000152">
        <property type="entry name" value="G protein-coupled receptor class C group 6 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF5">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00592">
        <property type="entry name" value="CASENSINGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584700" description="G-protein coupled receptor family C group 6 member A" evidence="16">
        <location>
            <begin position="23"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="17">
        <location>
            <begin position="17"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="GPCR family 3 nine cysteines" evidence="18">
        <location>
            <begin position="459"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO18894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="578" mass="66179" checksum="F2F8CE0B5E221FB2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4G3</accession>
    <name>A0A151M4G3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein GLIS1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GLIS1</name>
        <name evidence="15" type="ORF">Y1Q_0003524</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
        <property type="protein sequence ID" value="KYO19388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4G3"/>
    <dbReference type="STRING" id="8496.A0A151M4G3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000048">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000453">
        <property type="entry name" value="GLIS family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN GLIS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="576"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="638"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO19388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="784" mass="86334" checksum="E3F12908A6E93B6B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M537</accession>
    <name>A0A151M537_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0007543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006584">
        <property type="protein sequence ID" value="KYO19633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M537"/>
    <dbReference type="STRING" id="8496.A0A151M537"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO19633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="344" mass="39288" checksum="1CD7D36FB6B24FFA" modified="2016-06-08" version="1">MRKPDGLLRLCVDYRRLNVLAVFDAFPMPQVDKLIERIGEAQYILTLDLAKGYWQIPVAPADRPKTAFGMPWGLCEFVRMPFGPHGAAATFQQLIDRLLAPHAGYVAAYIDDIIIYSPTWAHHKQALRAILSELRQASLTANPQKCALAKRETKYLGFLVGRGTIRPLADKVETVQNFPAPQNCRQLRSFLGLTNYYRRFVPYFSELTAPLMEALKGRRNGTVKWMEEMEQRFGKLKQALCEAVIMRTPNFRKTFILQTDASETAVGAVLTQEEEGIERPIAYASRKLSAAERRYATIEQGCLAIRWAVDHFRYYLMGREFKLVTDHAPLRWLSTARTDNARIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5C1</accession>
    <name>A0A151M5C1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tuftelin isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TUFT1-1</name>
        <name evidence="3" type="ORF">Y1Q_0012348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006582">
        <property type="protein sequence ID" value="KYO19698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5C1"/>
    <dbReference type="STRING" id="8496.A0A151M5C1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051375">
        <property type="entry name" value="Tuftelin_GRINL1A/MYZAP/CCD68"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171">
        <property type="entry name" value="GDOWN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171:SF4">
        <property type="entry name" value="TUFTELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO19698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="427" mass="49046" checksum="AF6F76ACC10B4C28" modified="2016-06-08" version="1">MDWASPVPLRCFWTGEEMACRRSLTPPLLPSAIEAGTEAPGFYSWEEEERVLHQDSVTVLRLTLQNDPSGSWREPVKQKPVGKAFAMVANKSTNSHSLASECIKSNDGHEEIIKVYLRGRGQEKAKPEESISQLKRDVRYVQEARTSLKNLREEISNKPENPQGAKSSLQPAQVTLEKQNGVWHPESLHTSSVDQEEDYVGEDVEKIRETAKRLFTRLQETEKRHQLDRKAFETTVSQYQREVEQNTAARGRAEERAAAKEAEVEELQRLVLGMEKEHQSLLKKMKESEDELEKLRSLESDRLTEQERSAKLEKEVAMLREKIHHLDDMLKSQQRKVRHMIEQLQNSKTVIQAKDEIIQELREQVAHLTAENLEMHERIDHLIEKQINLGSSSFSSRPRSKSEYVSSKSLAGPLKPKPLPLIRVVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5T0</accession>
    <name>A0A151M5T0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0006838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006526">
        <property type="protein sequence ID" value="KYO19876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5T0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="77" mass="8663" checksum="61CA12200EFB28C1" modified="2016-06-08" version="1">MHPNLLPLIQISHVKGVSEPQEERHRGCCLVLRMQSRISDKRSPSVNLVNSSAPNLPDPGNLRVSCGSQWHCSYWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6C6</accession>
    <name>A0A151M6C6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MRPL47</name>
        <name evidence="8" type="ORF">Y1Q_0010649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019334127.1">
        <property type="nucleotide sequence ID" value="XM_019478582.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6C6"/>
    <dbReference type="STRING" id="8496.A0A151M6C6"/>
    <dbReference type="GeneID" id="102558667"/>
    <dbReference type="KEGG" id="amj:102558667"/>
    <dbReference type="CTD" id="57129"/>
    <dbReference type="eggNOG" id="KOG3331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M6C6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO20058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="240" mass="27883" checksum="47CCC85B91D5DF14" modified="2016-06-08" version="1">MAAAVVAALSRHLTGALRVSAALRALPSPSPALSPLPGSRPQGARRGLHATACRKGLGEFFDDEKNWGETTVKSGDAWKITLLRGKSNEDLHKLWYVLLKEKNMLLTLQQEAKRQRLPMPSPERLEKVETSMKRLDEVVEERETALRLLQTGQEKSKPGEWRQDFLGRTNWYTLREWPIPWYLNKRHKRKRFFYTSNVKHFIRLRIEKALRQKARMNALERKKQKLLQKKFPHLAAKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M791</accession>
    <name>A0A151M791_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M791"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="116" mass="11928" checksum="1662ADF0314ECE9F" modified="2016-06-08" version="1">MSDLEWVALPPFTPGVHNSRDDKAQRPSGEPPRGQTSVVLRSASHLHQGKVGIHGTRGLLEFAQPEMMAQGTGGSDSGPSWCRPASHGDGAVACPPARGILLGDGGARGIAGPQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAI0</accession>
    <name>A0A151MAI0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">YjeF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EDC3</name>
        <name evidence="11" type="ORF">Y1Q_0001709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273209.1">
        <property type="nucleotide sequence ID" value="XM_006273147.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059570869.1">
        <property type="nucleotide sequence ID" value="XM_059714886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAI0"/>
    <dbReference type="STRING" id="8496.A0A151MAI0"/>
    <dbReference type="GeneID" id="102567332"/>
    <dbReference type="KEGG" id="amj:102567332"/>
    <dbReference type="CTD" id="80153"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MAI0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01737">
        <property type="entry name" value="LSm16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000026">
        <property type="entry name" value="Enhancer of mRNA-decapping protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000001">
        <property type="entry name" value="Enhancer of mRNA-decapping protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034107">
        <property type="entry name" value="Lsm16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16598">
        <property type="entry name" value="Edc3_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="9">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="8">
        <location>
            <begin position="283"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO21525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="508" mass="56301" checksum="B24D7AA6381E4AD0" modified="2016-06-08" version="1">MATDWLGSIVSINCGESLGVYQGRVSAVDQVSQTISLTRPFHNGVKCLVPEVTFRAGDITELKILEIPGPGEIGQYGDLQQTELGIPGVGCQVGTNQNGTGKMLKKPTASSSAPQNIPRRTDMKNQDVVISPQQQQCSKSYMDRHVESLNASKGFRRRHNSWSSSSRHPNQVTPKKSGLKNGQMKTKDDECFGDDIEELPDTDFDFEGNLALFDKAAVFEEIDTYERRSGTRSRSTPNEKPARYRHDENILESEPIVYRRIIVPQNNSKEFCTDSGLVVPSVSYELHKKLLSVAEKHGLTLERRLEMTGVCASQMALSLLGGPNRLNPKNVHQRPTVALLCGPHVKGAQGISCGRHLSNHDVHIILFLPNFVKMLEPITNELNLFSKTQGQQVSSVKDLPDTPVDLVINCLDCHENAFLRDQPWYKAAVDWANKNRAPVLSIDPPICEMEQGIDAKWSLALGLPLPLGERAGRVYLCDIGIPQKVFQEVGINYHSPFGCKFVIPLHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAM3</accession>
    <name>A0A151MAM3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAM3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="8172" checksum="830812FF973E4740" modified="2016-06-08" version="1">MFLMPTGRLVGPYTPQQEVMEVELEPSCQSEGRGARTASRAAGWPGQQPSSHIPGRRRMGSLWQNQSSSEYPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAR3</accession>
    <name>A0A151MAR3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulation of nuclear pre-mRNA domain-containing protein 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPRD2</name>
        <name evidence="3" type="ORF">Y1Q_0004518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006289">
        <property type="protein sequence ID" value="KYO21569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MAR3"/>
    <dbReference type="eggNOG" id="KOG2669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF40">
        <property type="entry name" value="REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1207"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="PROSITE" id="PS51391"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="1445" mass="155771" checksum="2BBFE11A5191DDC0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCD8</accession>
    <name>A0A151MCD8_ALLMI</name>
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        <submittedName>
            <fullName evidence="15">Mucin-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MUC6</name>
        <name evidence="15" type="ORF">Y1Q_0000771</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homomultimer; disulfide-linked. The N- and C-terminus mediate their assembly into higher order structures to form filaments. The CTCK domains of two polypeptides associate in the endoplasmic reticulum to generate intermolecularly disulfide-bonded dimers. These dimers progress to the Golgi apparatus, which is a more acidic environment than the endoplasmic reticulum. Under acidic conditions, the N-termini form non-covalent intermolecular interactions that juxtapose assemblies from different CTCK-linked dimers to produce long, disulfide-linked polymers that remain highly compact until secretion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <sequence length="2218" mass="244189" checksum="06868C3EE23A56ED" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDR4</accession>
    <name>A0A151MDR4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDR4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7225" checksum="26FE000AF3C6CD24" modified="2016-06-08" version="1">MSFDWWLGEAPGSYCSGSGKLQSSNMQAALEEEGFGGGNRIGREFLGHQIQSLAFEETMTYMIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF51</accession>
    <name>A0A151MF51_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0005583</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF51"/>
    <dbReference type="STRING" id="8496.A0A151MF51"/>
    <dbReference type="eggNOG" id="KOG2579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003823">
        <property type="term" value="F:antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001867">
        <property type="term" value="P:complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF433">
        <property type="entry name" value="FICOLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0176">Collagen</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO23135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="143" mass="15949" checksum="7A1AD9DD68037ADC" modified="2016-06-08" version="1">MGMEVTSIFTLLLCSTGINELRIDLEDFENNKTFAKYGSFSISGESDKYKLTLGDMTAGDAGDSLTYHNNMMFSSKDQDNDLDPSNCASTLRGGWWFNNCLKSNLNGEYLHGAHDCPDRGVIWIEGCGDKYSYKVSEMKIRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHX4</accession>
    <name>A0A151MHX4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006127">
        <property type="protein sequence ID" value="KYO24117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHX4"/>
    <dbReference type="STRING" id="8496.A0A151MHX4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO24117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="720" mass="82501" checksum="A7B103B6B206887C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHZ3</accession>
    <name>A0A151MHZ3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006126">
        <property type="protein sequence ID" value="KYO24127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHZ3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO24127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="128" mass="13832" checksum="5787C4738B210893" modified="2016-06-08" version="1">MGPQDASFGDSASLSMPPPTTPQHFKQDWMISQLPKRSGSFPQAHHTWGSNGHFSGFCSIEEKPGGSTHPCKESSRLPPQTKIPRKAPHGSPDCRSIGSIIPHQEMEAGSHEDKGTQTNLPLYAEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIE2</accession>
    <name>A0A151MIE2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Angiopoietin-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ANGPTL1</name>
        <name evidence="9" type="ORF">Y1Q_0004324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIE2"/>
    <dbReference type="STRING" id="8496.A0A151MIE2"/>
    <dbReference type="eggNOG" id="KOG2579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151MIE2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072377">
        <property type="term" value="P:blood coagulation, common pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="191"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO24295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="411" mass="47735" checksum="A357BF8A4A925C8D" modified="2016-06-08" version="1">MDIENLKDVLSKQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNVTTEMLKMATRYRELEVKYAALTDLVNNQSVIISLLEEQCLRVFSRQDTHGSPPLVQVVPQHIPNSQPYTPVLLGGNEIQRDPGYPRDRDVRPPPDPATFPTKSPFRIPPLALINEGPFKDCQQAKEAGYSNSGIYMIKPENSNEPMQLWCENSLDPGGWAVIQKRTDGSFNFFRNWDSYKKGFGNVDGEYWLGLENIYMLTNQDNYRLLIELEDWSNKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSMIWHNGKQFTTLDRDRDMYTGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKYQDGIFWAEYRGGSYSLKAVQMMIRPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJV0</accession>
    <name>A0A151MJV0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box/SPRY domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">F-box only protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FBXO45</name>
        <name evidence="8" type="ORF">Y1Q_0014092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FBXO45/Fsn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006003">
        <property type="protein sequence ID" value="KYO24796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJV0"/>
    <dbReference type="STRING" id="8496.A0A151MJV0"/>
    <dbReference type="eggNOG" id="KOG3953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060386">
        <property type="term" value="P:synapse assembly involved in innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22111">
        <property type="entry name" value="F-box_FBXO45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000024">
        <property type="entry name" value="F-box/SPRY domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000017">
        <property type="entry name" value="F-box/SPRY domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF7">
        <property type="entry name" value="F-BOX_SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="64"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO24796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="255" mass="28546" checksum="F9B2A28DBFF9CCD2" modified="2016-06-08" version="1">MAAAGGAGWRLPGRVLELVFSYLELRELRSCALVCKLWHRVLHGDENSEVWRSLAARCLAEEALRTDVLCNVPTYKGKVRAFHHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKSRLKSHLSLAVELTCQHYTILCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKF6</accession>
    <name>A0A151MKF6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO25006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKF6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="8222" checksum="DA28BFD113776518" modified="2016-06-08" version="1">MGHSGSNSRSSSFSKERGWIRDCDFRLSGTCFCSLKDSCEIRGNRNNKVLPWKWLLLSREQQPSTAVKRKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKK2</accession>
    <name>A0A151MKK2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKK2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="89" mass="9821" checksum="0E32C92A19B9747B" modified="2016-06-08" version="1">MNRGMNRRHKSYGKATCLTVQLEADGVEEQGTDPAPTEVNIKLLSDWNRAGSSLCSCAMVAPHATLSGFIVHQPHPDIRKLQFLCFPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN22</accession>
    <name>A0A151MN22_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L53, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRPL53</name>
        <name evidence="9" type="ORF">Y1Q_0003711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261915.1">
        <property type="nucleotide sequence ID" value="XM_006261853.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN22"/>
    <dbReference type="STRING" id="8496.A0A151MN22"/>
    <dbReference type="GeneID" id="102561760"/>
    <dbReference type="KEGG" id="amj:102561760"/>
    <dbReference type="CTD" id="116540"/>
    <dbReference type="eggNOG" id="ENOG502S5X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6618793at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MN22"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052473">
        <property type="entry name" value="mtLSU_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33618">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L53, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33618:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO25922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="110" mass="12332" checksum="66E2F5869BB2E84F" modified="2016-06-08" version="1">MAARRVMVGLRAVKSVRVCFCPFETNVESTREFLHHISSKKARSSNSNCVVTTDVRHDGSEPMVDIMFADGERLIMKGANLTTPEMLFALNSRCRAKELEAEEKVKKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN73</accession>
    <name>A0A151MN73_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Telomeric repeat-binding factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TERF1-1</name>
        <name evidence="21" type="ORF">Y1Q_0003752</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN73"/>
    <dbReference type="STRING" id="8496.A0A151MN73"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071532">
        <property type="term" value="F:ankyrin repeat binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905839">
        <property type="term" value="P:negative regulation of telomeric D-loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.210:FF:000001">
        <property type="entry name" value="Telomeric repeat-binding factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000129">
        <property type="entry name" value="Telomeric repeat-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.210">
        <property type="entry name" value="Telomere repeat-binding factor, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036507">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017357">
        <property type="entry name" value="TERF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038016">
        <property type="entry name" value="Telomere_bd-1_Pin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63600">
        <property type="entry name" value="Telomeric repeat binding factor (TRF) dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="16 18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Myb-like" evidence="19">
        <location>
            <begin position="289"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="20">
        <location>
            <begin position="292"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO25974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="369" mass="42774" checksum="7D7D7B34D780249C" modified="2016-06-08" version="1">MLEFTCHCLCRHFRDGRVPDFQRSRDAAQAIINGLPKITAHQRKAVNLCQFLARIAEGKSLGYHFESDQRISPLESALSIWIQLEKEESKLEKLHEDIRRLILIQAVAVYIEKGYYKEASEVLDRLDSEPNKTLRMKLTMIINRRDPYVPFLQNFSYNLLMDKIKSYIDDFLKKSATNFLIKAAVKEVEAKRLGGKASQDKPASVVKTNHGNILEMEQSNFEDVNHISKRSSGNARKQLRSHIEAHTPLNPEMAPFPRIKKRGRTGACRNLQNDLQNLKNNAETSSHMLTGRKKQRWTLEEDKKLEKGVKEFGMGNWAKILIHYDFNNRTGVMLKDRWRTMIKQHKHFVFEVSWSKKLVDLSADMSPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNC3</accession>
    <name>A0A151MNC3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/potassium-transporting ATPase subunit beta-1-interacting protein</fullName>
            <shortName evidence="7">Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NKAIN3-1</name>
        <name evidence="8" type="ORF">Y1Q_0003802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NKAIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNC3"/>
    <dbReference type="eggNOG" id="KOG4556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008516">
        <property type="entry name" value="Na/K-Atpase_Interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084:SF2">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084">
        <property type="entry name" value="T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05640">
        <property type="entry name" value="NKAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO26037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="196" mass="22647" checksum="BA9494C126C19A56" modified="2016-06-08" version="1">MGQLAALERQIFDFLGFQWAPILGNFLQIIVVILGLFGTIQFRPRYIVVYTVWTALWVTWNVFIICFYLEVGGLSKETDLMTFNISMHRSWWREHGPGCIRRVVRPSAPGILDDYSYVSVTGCIIDFQYLEVIHSAIQILLSLIGFVYACYVISVFMEEEDSFDFIGGLDSYSYRQTHQELVELKPVKPVEISNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNE6</accession>
    <name>A0A151MNE6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0003814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNE6"/>
    <dbReference type="STRING" id="8496.A0A151MNE6"/>
    <dbReference type="PhylomeDB" id="A0A151MNE6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="127" mass="14103" checksum="E456B8E0D9AC5300" modified="2016-06-08" version="1">MLDDLENFTGIVSVEGQKINNLHFADDIDLIAGTSEELQELTEMLDKTAKSYGMKITAEKSKAMTTSKITDSNIDMKISNEKLEKVTSFKYLGATITEDLTSGKEVKPKKVIATSQLTKLKQILDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNG6</accession>
    <name>A0A151MNG6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epidermal retinol dehydrogenase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0003831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNG6"/>
    <dbReference type="STRING" id="8496.A0A151MNG6"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000202">
        <property type="entry name" value="Short-chain dehydrogenase/reductase family 16C member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF749">
        <property type="entry name" value="EPIDERMAL RETINOL DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO26072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="254" mass="28152" checksum="0A5885628C591EA2" modified="2016-06-08" version="1">MALKFARLGAVLVLWDIDPEGNKETGRLAKEAGAVRVHTYTCDCSKREEVYKVADQVKKEVGDVNILINNAGIVSGKKFIESLDSRMQKTMEVNAMAHFWTYKAFLPAMVASNCGHLVSIASAAGLFGTNELADYCASKFAAVGFAETIDVEMHALKKTGIKTTIVCPYFINTGMFDGVTTRFPRLLPILDPEYAAETIVNAILREQVYLIIPALVCILFAVKNLLPTKVIHLWEDYTGVSHSMDHFRGWVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNJ3</accession>
    <name>A0A151MNJ3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">TCEA1</name>
        <name evidence="23" type="ORF">Y1Q_0003856</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with EAF2. Associates with UBR5 and forms a transcription regulatory complex made of CDK9, Pol II, UBR5 and TCEA1/TFIIS. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260001.1">
        <property type="nucleotide sequence ID" value="XM_006259939.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNJ3"/>
    <dbReference type="STRING" id="8496.A0A151MNJ3"/>
    <dbReference type="GeneID" id="102570534"/>
    <dbReference type="KEGG" id="amj:102570534"/>
    <dbReference type="CTD" id="6917"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MNJ3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000001">
        <property type="entry name" value="Transcription elongation factor A (SII), 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000002">
        <property type="entry name" value="Transcription elongation factor A (SII), 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR A PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="23" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 18" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="21">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="22">
        <location>
            <begin position="143"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="20">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO26104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="304" mass="34042" checksum="3B30001EECDAEFFC" modified="2016-06-08" version="1">MTAEDEIIRIAKKMDKMVQKKNAAGALDLLKELKNIPMTLELLQSTRIGMSVNAIRKQSTDEEVTSLAKSLIKSWKKLLDGPSTDKDSEEKKKEPASSSQNSPEAREESSSSSNSSSRKEETNTPSNSFIHSHPRAPVTTDSVRMKCREMLAAALKTGGDYIAIGADEEELGSQIEEAIFQELNNTDMKYKNRVRSRIANLKDPKNPNLRKNVLCGNIPPDMFAKMTAEEMASDELKEMRKNLTKEAIREHQMAKTGGTQTDLFTCGKCKKKNCTYTQVQTRSADEPMTTFVVCNECGNRWKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MP05</accession>
    <name>A0A151MP05_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adipose-secreted signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0000208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADISSP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005607">
        <property type="protein sequence ID" value="KYO26275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MP05"/>
    <dbReference type="STRING" id="8496.A0A151MP05"/>
    <dbReference type="KEGG" id="amj:102576609"/>
    <dbReference type="eggNOG" id="ENOG502RXJD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6246153at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026794">
        <property type="entry name" value="ADISSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13287">
        <property type="entry name" value="ADIPOSE-SECRETED SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13287:SF2">
        <property type="entry name" value="ADIPOSE-SECRETED SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15006">
        <property type="entry name" value="DUF4517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO26275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="174" mass="19121" checksum="FD4DACB4AB2C544E" modified="2016-06-08" version="1">MAAANKGVKAKGGGVRFAPSHPPEGAHSHVHFDEKLHDSVVMVTQEKDGNFLVKVGFLKILHKYEITFLLPPVQSLGKDICAVPVPNLNLRVISITPVSEGYSVKCEYTAHKEGVLKEEMVLTSETSDSTCVKVVVQARVMDRHHGTPMLLEGVRCIGAELEYDSEQSDWHGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPF1</accession>
    <name>A0A151MPF1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sister chromatid cohesion PDS5-like protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PDS5A</name>
        <name evidence="8" type="ORF">Y1Q_0010380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005510">
        <property type="protein sequence ID" value="KYO26404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MPF1"/>
    <dbReference type="GeneID" id="102559469"/>
    <dbReference type="CTD" id="23047"/>
    <dbReference type="eggNOG" id="KOG1525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001146">
        <property type="entry name" value="PDS5 cohesin associated factor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000064">
        <property type="entry name" value="Sister chromatid cohesion protein PDS5 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF1">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1151"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1153"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1186"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1210"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1239"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1336"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1356"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1435"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1451"/>
            <end position="1461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO26404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1461" mass="166636" checksum="D4C69C604D7362E1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSJ7</accession>
    <name>A0A151MSJ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">USB1</name>
        <name evidence="9" type="ORF">Y1Q_0003652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 3'-end uridylyl-adenosine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine</text>
            <dbReference type="Rhea" id="RHEA:67896"/>
            <dbReference type="Rhea" id="RHEA-COMP:17385"/>
            <dbReference type="Rhea" id="RHEA-COMP:17386"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:85644"/>
            <dbReference type="ChEBI" id="CHEBI:176518"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine</text>
            <dbReference type="Rhea" id="RHEA:46052"/>
            <dbReference type="Rhea" id="RHEA-COMP:17384"/>
            <dbReference type="Rhea" id="RHEA-COMP:17385"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:85643"/>
            <dbReference type="ChEBI" id="CHEBI:85644"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:46053"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSJ7"/>
    <dbReference type="STRING" id="8496.A0A151MSJ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1140.10:FF:000002">
        <property type="entry name" value="U6 snRNA phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO27486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="245" mass="28146" checksum="CEA9512A582E76C4" modified="2016-06-08" version="1">MKSPTAPRLPVPTSVLNMFKDQEEEVVDDSTKHGGRVRNFPHVRGNWTTYVYMPYEASEDFLELLELLISHARTYAVSLAAMEEFHISLSQNVVLRYHWITPFVQSLKEHLATAYRFFCTVDQVKVYTNQNKTRTFVGLEVSSGHPQLLELVSGVDRVMEEFDLPTFYKNPSFHISLAWCVGDLTDKLEGQCLQKLQEIVDGFEDSAFLLRIQWEQIRCKSGNKLFSFPLSSQLLQLPLASRNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV92</accession>
    <name>A0A151MV92_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">EH domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0015996</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV92"/>
    <dbReference type="STRING" id="8496.A0A151MV92"/>
    <dbReference type="eggNOG" id="KOG1954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF57">
        <property type="entry name" value="EH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="415"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO28404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57836" checksum="01EE883E48E243F5" modified="2016-06-08" version="1">MRKLLPLEEHYRFHDFHSPALEEADFENKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFVAVMYGDAEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNEVLKSISIIDSPGILSGEKQRISRGYDFCQVLQWFGERVDRIILLFDAHKLDISDEFSEAIKSFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYVGSFWAQPLQNTENRRLFEVEAQDLFHDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISHLKKEMPSVFGKENKKKELISRLPEIYVELQREYQISQGDFPEVKKMQEQLEVCDFTKFHSLKPKLIEAVDNMLANKIASLMSLISQEENNMPTEMVHGGAFDGTMAGPFDHGYGEGAKEGAGEQEWIVAKDKPAYDEIFYTLSPVNGKISGVSAKKEMVTSKLPNSVLGKIWKLSDCDNDGMLDDEEFALAKHLIKIKLDGYELPNNLPPHLVPPSHRKPLQVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX31</accession>
    <name>A0A151MX31_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Relaxin-3 receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RXFP3</name>
        <name evidence="10" type="ORF">Y1Q_0009803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX31"/>
    <dbReference type="STRING" id="8496.A0A151MX31"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151MX31"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF951">
        <property type="entry name" value="RELAXIN FAMILY PEPTIDE_INSL5 RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO28979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="342" mass="37629" checksum="FC8AD2322D751551" modified="2016-06-08" version="1">MRGKRGWRKSSMNLFVTSLAATDLQFVLTLPFWAVENALDFTWLFGRVMCKVVSYVTAMNMYASVFFLTAMSVARYRTVASVLKSQPRGGCGCGCGARGLCALIWALAVVAALPHAIFSTTANVFGEELCLLRFPDSPSARVQLWLGLYQVQKVLLGFVVPLGVISLCYARLVRFLRGRHASQRRSAKVTRSVSVVVLSFFVCWLPNQALTAWGVLVKLNAVPFGPAYFLSQAYLFPVSVCLAHCNSCLNPVLYCLMRREFRQALKSLLWRLASPSLTSMRPFTLSTKPEPDEQALPALVPLPAAAPLPATTPSELLYYPPGVVVYSGRCDLLPAGPSEQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXL8</accession>
    <name>A0A151MXL8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-1-syntrophin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SNTB1</name>
        <name evidence="11" type="ORF">Y1Q_0017905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the syntrophin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXL8"/>
    <dbReference type="STRING" id="8496.A0A151MXL8"/>
    <dbReference type="eggNOG" id="KOG3551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01258">
        <property type="entry name" value="PHsplit_syntrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000304">
        <property type="entry name" value="Beta-1-syntrophin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000307">
        <property type="entry name" value="Beta-1-syntrophin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041428">
        <property type="entry name" value="PHsplit_syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF11">
        <property type="entry name" value="BETA-1-SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18012">
        <property type="entry name" value="PH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="188"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO29250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="404" mass="44832" checksum="6CDDCA5A00678994" modified="2016-06-08" version="1">MPILISKIFKGLAADQTQALYVGDAILAVNGTDLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGSASSDPLSQLSLSVNRDKKTIPLKMCYATHNMAVSDPENRLIEVHSPDGKHTVVLRSKDSATTQAWFNAIHSSINDLIPRVVAEVRDQLGKTGIAGSREIRHLGWLAEKVPGENEKHWKPALVVLTEKDLLIYESMPRMKEAWFSPLHTYPLLATRLVHSGPGKGSPQSGVDLSFATRTGTRQGIETHLFRTETSRDLSLWTRNIVQGCHNSAELITEITTSCTYKNQECHLTIHYEHGFSLSTEPQDGAFSKTIVQYPYEKLKMSSDDGIRMLYLDFGGKDGELQLDLHSCPKPIVFIIHSFLSAKITRLGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXU1</accession>
    <name>A0A151MXU1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">EXTL1</name>
        <name evidence="18" type="ORF">Y1Q_0017924</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.225" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXU1"/>
    <dbReference type="STRING" id="8496.A0A151MXU1"/>
    <dbReference type="eggNOG" id="KOG1021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050508">
        <property type="term" value="F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050509">
        <property type="term" value="F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000034">
        <property type="entry name" value="Exostosin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF3">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="16">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="17">
        <location>
            <begin position="165"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO29275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="431" mass="49901" checksum="B2B0CFEE1F629663" modified="2016-06-08" version="1">MGWGPRYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVIDWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAVAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVIVIEGESKVMSSRFLPYDNIVTDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNTKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYTHYLPANLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZL0</accession>
    <name>A0A151MZL0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0006549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004446">
        <property type="protein sequence ID" value="KYO29934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZL0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001872">
        <property type="term" value="F:(1-&gt;3)-beta-D-glucan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071226">
        <property type="term" value="P:cellular response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042808">
        <property type="entry name" value="CLEC7A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="113"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO29934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="217" mass="24587" checksum="4858FCB7258371E5" modified="2016-06-08" version="1">MHSQQPLLLEELWIQLGSCSASLPWRLIAVILGSLCLVFLAISGVLGVLFFQSNLQVANQTRTLRQQEEILKNWTQLHEALESCRGTSNDLQTQTSTLNAKNSSTVSDCWKNQERKFYLFMDKKKTQQACKNYCSSRSSRLLKTENDDELNFLKPLANFHWIGLTRNGTGTSWAWEDGTSYSPNLFFIHSMDTCFSDVRDPLPNFAGNFTSLGCSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N054</accession>
    <name>A0A151N054_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0019599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004330">
        <property type="protein sequence ID" value="KYO30065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N054"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SCAN box" evidence="5">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="6">
        <location>
            <begin position="203"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO30065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="267" mass="30190" checksum="2E4AD1ED8441A1ED" modified="2016-06-08" version="1">MQPPCEAELPSATPQLAPWDELPTPEPWRQLFCGLCYREAEGPGKICSCLRELCRHWLDSQRRSKEQMLELVVLEQFLAILPPEMRSWVCGCHVETCAQAVALAEGFQLGQAEDRKLQVTVRVKIEERSSDKMQPAKALKEPGAGTLSRADQQPPEEGPVNLEPQRPSPGRPGQSGSLTPGPGQLHEGQGRPAKQGESMQLWEVFEDVAVYFTREEWELLEEEDKGLYRDQMLMNHQALLSLGLPEIKDKHCRWVSPKHWGMWSMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0M7</accession>
    <name>A0A151N0M7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Paired box protein Pax-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0018485</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004263">
        <property type="protein sequence ID" value="KYO30324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0M7"/>
    <dbReference type="STRING" id="8496.A0A151N0M7"/>
    <dbReference type="eggNOG" id="KOG0849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000516">
        <property type="entry name" value="Transcription factor Toy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="74"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO30324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="281" mass="30518" checksum="86D00E6FB3B74356" modified="2016-06-08" version="1">MGADSLYKKIGMLNIQNAAWSGRQDWYPESLVSPQPNPDSCQQLDGGLDPEHRSGAVGDDLDESQIRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQAGSTGHLGLGGAFPGASVFPPVPAPPGAGTVLGRSEATLPNSYGGMPPLPSFSMASSLPIQQAVLPVASQPSSYACMIPASSSGRSYDSYSPPQLPTHMGSQALGASTPASTGLISPGVSVPVQVPGGDPDLSQYWPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1G3</accession>
    <name>A0A151N1G3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epithelial membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">EMP2</name>
        <name evidence="18" type="ORF">Y1Q_0008165</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="15">Interacts with PTK2; regulates PTK2 activation and localization. Interacts with ITGB3; regulates the levels of the heterodimer ITGA5-ITGB3 integrin surface expression. Interacts with P2RX7 (via C-terminus). Interacts with ITGB1; the interaction may be direct or indirect and ITGB1 has a heterodimer form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the PMP-22/EMP/MP20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006271315.1">
        <property type="nucleotide sequence ID" value="XM_006271253.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019350308.1">
        <property type="nucleotide sequence ID" value="XM_019494763.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059572835.1">
        <property type="nucleotide sequence ID" value="XM_059716852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1G3"/>
    <dbReference type="STRING" id="8496.A0A151N1G3"/>
    <dbReference type="GeneID" id="102557658"/>
    <dbReference type="KEGG" id="amj:102557658"/>
    <dbReference type="CTD" id="2013"/>
    <dbReference type="eggNOG" id="ENOG502RYYE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9939098at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N1G3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001952">
        <property type="term" value="P:regulation of cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000023">
        <property type="entry name" value="Epithelial membrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003933">
        <property type="entry name" value="EMP-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004032">
        <property type="entry name" value="PMP22_EMP_MP20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF32">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01453">
        <property type="entry name" value="EPMEMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01455">
        <property type="entry name" value="EPMEMPROT2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01221">
        <property type="entry name" value="PMP22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585650" description="Epithelial membrane protein 2" evidence="17">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO30505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="19010" checksum="8DFDECE3493DD7AF" modified="2016-06-08" version="1">MLILLAFIIVFHITSAALLFISTIDNAWWVGKDFSTDVWQICTNITNCTVINENMAEYQSIQAVQAAMILSTVFCCVAFLVFILQLFRLKQGERFVLTSIIQLLSCLCVMIAASIYTDRHEELHEAVEYLQLNVASGQYGYSFILAWIAFAFTLISGVMYLILRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2D1</accession>
    <name>A0A151N2D1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-2-glycoprotein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Apolipoprotein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Beta-2-glycoprotein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">APOH</name>
        <name evidence="18" type="ORF">Y1Q_0016357</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273063.1">
        <property type="nucleotide sequence ID" value="XM_006273001.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2D1"/>
    <dbReference type="STRING" id="8496.A0A151N2D1"/>
    <dbReference type="GeneID" id="102569027"/>
    <dbReference type="KEGG" id="amj:102569027"/>
    <dbReference type="CTD" id="350"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6103690at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000011">
        <property type="entry name" value="CUB and sushi domain-containing protein 3 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015104">
        <property type="entry name" value="Sushi_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF549">
        <property type="entry name" value="BETA-2-GLYCOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09014">
        <property type="entry name" value="Sushi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585666" description="Beta-2-glycoprotein 1" evidence="16">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="203"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="350" mass="39095" checksum="2F03BDD00DD82917" modified="2016-06-08" version="1">MYSTVLFLWIVTLTHCVLAGNICPKPPEVPFATIDVDKKEYQPGEEVIYTCRPGYVHQGGTRKYACNWSGRWLLNTMKCTPKKCPFPGLLENGKISFTELTFQSTITFSCNPGYILNGARISQCMADGRWSGTPPHCQPVTCPPPKIPEFGVISYHTLKPGNVSVFQDMITFECLPSFALLGNETAMCTANGNWSNIPECKYVTCPTPTGIENGFINLVVRRTYGYKERVSFGCNGRYVLDGPRESTCEKTSDWSIKPTCKAPCKIPVKKATVLYKGEKVAVQDGLKEGIQHDETISFFCKNKEKDCVYTVPTSCIDGNLTVPECFKERGFFSSVFKKDYAERTQCEDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3R3</accession>
    <name>A0A151N3R3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Natriuretic peptides A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NPPB</name>
        <name evidence="9" type="ORF">Y1Q_0006046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the natriuretic peptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3R3"/>
    <dbReference type="STRING" id="8496.A0A151N3R3"/>
    <dbReference type="GeneID" id="102572997"/>
    <dbReference type="KEGG" id="amj:102572997"/>
    <dbReference type="CTD" id="4878"/>
    <dbReference type="eggNOG" id="ENOG502SD0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9892281at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N3R3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051427">
        <property type="term" value="F:hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006182">
        <property type="term" value="P:cGMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000663">
        <property type="entry name" value="Natr_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030480">
        <property type="entry name" value="Natr_peptide_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050787">
        <property type="entry name" value="Natriuretic_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002408">
        <property type="entry name" value="Natriuretic_peptide_brain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14066">
        <property type="entry name" value="ATRIAL NATRIURETIC FACTOR PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14066:SF10">
        <property type="entry name" value="NATRIURETIC PEPTIDES B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00212">
        <property type="entry name" value="ANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00712">
        <property type="entry name" value="BNATPEPTIDE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00710">
        <property type="entry name" value="NATPEPTIDES"/>
    </dbReference>
    <dbReference type="SMART" id="SM00183">
        <property type="entry name" value="NAT_PEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00263">
        <property type="entry name" value="NATRIURETIC_PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0838">Vasoactive</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585708" evidence="8">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO31463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="140" mass="15719" checksum="DF2C5F69600F05C8" modified="2016-06-08" version="1">MDTKGSFLYGLLLLLLFQFQSNRANPIYSLSPAKELASMEALLERLEDKFSLMEALESSPDLQEPKAEEEMPAQLLEDSDVPQPEPRFTPSAPQSYRDTFLKKLRGLQAPKMMRDSGCFGRRIDRIGSLSGMGCNGSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N631</accession>
    <name>A0A151N631_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N631"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="141" mass="15753" checksum="E185B8842458DBF1" modified="2016-06-08" version="1">MCFLVLQETFNETRPGAVGDTYKGTRQEKANGILTSKGRPVETFCDQAKWGKAQHTENTAHARGEEEALSRFPWQLTHVGWIFKAYRILSAIEMHPTQCYFQVRSSPGQCGIVYVQLCNPDRSPLQGKVAEHHAESAESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7A3</accession>
    <name>A0A151N7A3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7A3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="132" mass="14281" checksum="DB15A60AA7FB547F" modified="2016-06-08" version="1">MLISPGQLHRYDVQEEETCEVLMPPIRAKLKRVPPPRLCHSLFLSRVRPLGGCGLCHLLPRAPGFLPETCNNAGPHTAGSGLKCHCDKRLLAVAVLVQGQGRHPLFSSHQSLQAQSSITSPYGIKLAKGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7R3</accession>
    <name>A0A151N7R3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HLA class II histocompatibility antigen, DP beta 1 chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0004980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003855">
        <property type="protein sequence ID" value="KYO32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7R3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="69"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="211" mass="22865" checksum="DC1336636B67765B" modified="2016-06-08" version="1">MQNGDWTFQILVMLEMTPRSGDVYTCQVEHSSLPSPITVLCEAQSDSARSKMLTGVGGFVLGLIFLVLGLLVYLKNKKGGSGFLGSPTSGAAVKATRSTTSASTAFPPACSQAEVFEEIAQLVQSALDGYHVCIFAYGQTGSGKTYTMEGPDNLDQETLGMIPQAMRQVFQGTREPEPKGWETYRKELGEDPMTGRLEFKTRKSAEDSLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N868</accession>
    <name>A0A151N868_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RNF144A</name>
        <name evidence="19" type="ORF">Y1Q_0011281</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RBR family. RNF144 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03003826">
        <property type="protein sequence ID" value="KYO32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N868"/>
    <dbReference type="STRING" id="8496.A0A151N868"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20366">
        <property type="entry name" value="BRcat_RBR_RNF144A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16777">
        <property type="entry name" value="mRING-HC-C4C4_RBR_RNF144A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20352">
        <property type="entry name" value="Rcat_RBR_RNF144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000006">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000051">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="305" mass="34363" checksum="93727B69E578D9E9" modified="2016-06-08" version="1">MTGLEPKGLYCAAMTTARYRPTWDLVLDPLVSCKLCLGEYPVEQMTTIAQCQCIFCTLCLKQYVELLIREGLETAISCPDAACPKRGHLQENEIECMVASEIMQRYKKLQFEREVLLDPCRTWCPSSTCQSVCQLQESGPKNPQLVQCKACDIEFCSACKSNWHPGQGCQENMPISFLPGETSSVFKMEEDDAPIKRCPKCKVYIERDEGCAQMMCKNCKHAFCWYCLESLDDDFLLIHYDKGPCRNKLGHSRASVIWHRTQVVGIFAGFGLLLLVASPFLLLATPFVLCCKCKCNKGDDDPLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N933</accession>
    <name>A0A151N933_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0008447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003742">
        <property type="protein sequence ID" value="KYO33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N933"/>
    <dbReference type="STRING" id="8496.A0A151N933"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01504">
        <property type="entry name" value="PNCREATITSAP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585851" evidence="1">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="179" mass="20384" checksum="62D52E58903AE31B" modified="2016-06-08" version="1">MRTTAHLILCLLGCLVLSPWLEGAKTKDCPKDWLRYQGSCYGFFPQKITWAEAEAACQKQGHGAHLASILSSSATEVIAGYISSHYPDGNVWIGLHDPRHNRVWTWTDGSSFTYRAWRFWEPNNWMWREYCVELRHFWGKQESLALMAGQPAAQPGSGTLTRSRNRPCFLPGFFLGCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NA78</accession>
    <name>A0A151NA78_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NA78"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="11452" checksum="7B2AE71693AC6C07" modified="2016-06-08" version="1">MTREDDPEAFLKSFERATMVSGLDPSKWATKLGVLLVAQAQVAYSNMSRLDAHNYGKVKEEILYCLDITQESSCTPVALTSSAKLPYETGSESEGNNCTLQEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBY2</accession>
    <name>A0A151NBY2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBY2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="9172" checksum="1CDF21B085F98997" modified="2016-06-08" version="1">MFNLYQGLDCHIMSNLWKEWTVRFVRLSSSSRQWFLITLGPADRLCSSPAQGEGKGRRTSWVHLNQKSKHSLWLHPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCG4</accession>
    <name>A0A151NCG4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0023530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003442">
        <property type="protein sequence ID" value="KYO34450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCG4"/>
    <dbReference type="STRING" id="8496.A0A151NCG4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO34450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="115" mass="12429" checksum="7C305593A9A989AC" modified="2016-06-08" version="1">MRGAKGAEAAGGSTPYLSVMDQYGYQLGRVIGHGSYGVVYEAYFVKQKTKVAVKIISKKKASEDYLNKFLPREIQVHPFLHQGQGLGPARGQGPPGGRAELDPAPLTQCMGITHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCG6</accession>
    <name>A0A151NCG6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003404">
        <property type="protein sequence ID" value="KYO34502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCG6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7308" checksum="3A32CB4CBE09F48E" modified="2016-06-08" version="1">MSGTNISRGTSEVTDFYDRALGLDLNQKVAESRAFFIQNFSRIEACCSSEHAVLNTPSAYTGTAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDA3</accession>
    <name>A0A151NDA3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Muscle-restricted coiled-coil protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MURC</name>
        <name evidence="15" type="ORF">Y1Q_0015405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Caveola</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAVIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003364">
        <property type="protein sequence ID" value="KYO34609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDA3"/>
    <dbReference type="GeneID" id="102562112"/>
    <dbReference type="KEGG" id="amj:102562112"/>
    <dbReference type="CTD" id="347273"/>
    <dbReference type="eggNOG" id="ENOG502QQ9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8924144at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026752">
        <property type="entry name" value="Cavin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15240:SF4">
        <property type="entry name" value="CAVEOLAE-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15240">
        <property type="entry name" value="CAVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15237">
        <property type="entry name" value="PTRF_SDPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="263"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO34609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="355" mass="40436" checksum="364A35211E1918FE" modified="2016-06-08" version="1">MDHHEVISETDRIHQNRLSNVTEDEEEQDPAFTIVRVLDKVANIVDSVQASQKRIEERHRDMENAIKTVQIDILKLAQAHGNTSYTVNKLLEKTRKVSSKVKEVKARVEKQGDNVQKVEAKQEEMLRKNKFRVVIYQEETECPSSLSVIKERTRSENLDDDIFVLDDLSSDEEYYIEESRASRFKKSGMKGIDNIKKAFSRENMQKTRQNFGKKVNRLQSRIVTPERRERIRQSGEKLKQSGLRFKKTISQAAPTKETFKINKKNKERTVAEGQEEAQAIGGHAPAESGAAEPVTEEISYTEVITKVKKDKGSGTKRESQPAEKGVVAPETTVLKQETKEEGADDVPLLDLKQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFH9</accession>
    <name>A0A151NFH9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFH9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="8015" checksum="1E8BFE96EBB964A1" modified="2016-06-08" version="1">MVPEELNKSLMTSSRRLFLNLWHKVKKKVTSVRKWSNSKIISCEGCIYDVFYLSRHVKWLLLKNLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFI1</accession>
    <name>A0A151NFI1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TOX high mobility group box family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TOX2</name>
        <name evidence="7" type="ORF">Y1Q_0004723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003176">
        <property type="protein sequence ID" value="KYO35561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFI1"/>
    <dbReference type="STRING" id="8496.A0A151NFI1"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21995">
        <property type="entry name" value="HMG-box_TOX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000005">
        <property type="entry name" value="TOX high mobility group box family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051365">
        <property type="entry name" value="TOX_HMG-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781">
        <property type="entry name" value="AGAP000281-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781:SF5">
        <property type="entry name" value="TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="235"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="235"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO35561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="500" mass="54735" checksum="C09615027F909D5D" modified="2016-06-08" version="1">MPLLLVHRETNVHTHVDAAQVEFDGENMYVGMNDNNQEFLSANQTYNGQNENNEDYEIPPITPPNLPDPSLLHLVDHETGYHSLCHSLPPTSLIPTYSYQNMDLPAIMVSNMLSQDGHLLSNQLPTIQEMVHSDATSYDSNRQVPLINRPGMLAGPMTALSQSQLISQMGMRSGVTHGSPSPPGSKSATPSPSSSTQEEETESHYKVTGEKRPSADLGKKPKSQKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSSADQGETKSAQTNQPSKMIPPKQPMYTMPPQASSPYPGLGSFLSASDLQSYRGHPHPSLSRTLNSKPMLPSISASPPPSFQISPPLHQQLSLHHPQSSILNQSLNMQQVPQQSILSPSMALQVQPPMSSSPPGQQDFSHIPPEFQNSVGPRSPGASNPPGNSDWESDYPSRECGINHCSMLPRDKSLYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NH82</accession>
    <name>A0A151NH82_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0020645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003015">
        <property type="protein sequence ID" value="KYO36147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NH82"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF170">
        <property type="entry name" value="MEMBRANE SPANNING 4-DOMAINS A12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO36147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="210" mass="23122" checksum="3D2099BD69C06D48" modified="2016-06-08" version="1">MVILGLFQIACSTVCVVNGFIDGTFRTESSLSTTRAPIWAGVVMSVTGILALFSSQRKNPILVNAMLIASIFSCFTTLVVIIYASLTLNYGEEEEDLNHVPIHVVHTKFVLDKVVKGANIVMLIASIGSVVVVLTIAYMGCRSLPHCSCYDSRTGMEWLRPTEDQPQTVELVCTLQSHEDKILNSPIQFPDQDLDTEEETSKPPPYIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHV2</accession>
    <name>A0A151NHV2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0024091</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHV2"/>
    <dbReference type="STRING" id="8496.A0A151NHV2"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000194">
        <property type="entry name" value="Casein kinase I isoform delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO36330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="418" mass="47897" checksum="948F9DD4B3C6D417" modified="2016-06-08" version="1">MELRVGNKYRLGRKIGSGSFGDIYLGANIATGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDMDRERREHEREERMGQLRGSATRALPPGPPAGATANRLRNVAEPMASTPTSRIQQSVGNTSPRAISRVDRERKVGKRCHGFQHHRQVCHLIILGSEEGMSPDQCLLRRQAAPIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK13</accession>
    <name>A0A151NK13_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK13"/>
    <dbReference type="STRING" id="8496.A0A151NK13"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024831">
        <property type="entry name" value="Uroplakin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15446">
        <property type="entry name" value="UROPLAKIN III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="132" mass="14463" checksum="99C0C325719BCFA6" modified="2016-06-08" version="1">MPDPRDNATYKVPGTFPMPPCSPLHQEPMAPQEFAYDMGPSLECLNDTCLLGVLPGHSYRVRYVLYNHAMAQVAITNWSQPFETRGLPQSFHDIDPSPGGHSGGMVVLTVLLSLSVVLLLTAMGLTFLWGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKS4</accession>
    <name>A0A151NKS4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Exosome complex exonuclease RRP44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Protein DIS3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">DIS3</name>
        <name evidence="28" type="ORF">Y1Q_0017223</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the RNA exosome complex; within the complex interacts with EXOSC4, EXOSC7 and EXOSC9 of the exosome core complex (Exo-9). The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3; DIS3 associates with the base ring of Exo-9. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with DHX34; the interaction is RNA-independent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 24">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006278414.1">
        <property type="nucleotide sequence ID" value="XM_006278352.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKS4"/>
    <dbReference type="STRING" id="8496.A0A151NKS4"/>
    <dbReference type="GeneID" id="102573458"/>
    <dbReference type="KEGG" id="amj:102573458"/>
    <dbReference type="CTD" id="22894"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000125">
        <property type="entry name" value="exosome complex exonuclease RRP44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000002">
        <property type="entry name" value="exosome complex exonuclease RRP44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14 28" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="13" id="KW-0271">Exosome</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="26">
        <location>
            <begin position="64"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="27">
        <location>
            <begin position="467"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="935"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KYO37406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="960" mass="108778" checksum="45E4DF0652640EE9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLA7</accession>
    <name>A0A151NLA7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002664">
        <property type="protein sequence ID" value="KYO37596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLA7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9326" checksum="86D8DE2ED61A598E" modified="2016-06-08" version="1">MMLCKRPKGPEEYCMSAMGKGQKGITKADQHLWTYSIIPRDGIELRKGKDLGGKPISPSFLLSVCDGIHHIATSRNQAVTSVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NML2</accession>
    <name>A0A151NML2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MROH2B-like HEAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002540">
        <property type="protein sequence ID" value="KYO37960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NML2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="1">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="81" mass="9548" checksum="81B9CF0D3A00C3B0" modified="2016-06-08" version="1">MSKVQVSGIVSRLKDYHQEKRARTHRALILAYSRIAVHVPQMQLLPRVECDITWKVLQYYVTSFQIRDWDCTMLGTGLPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMS7</accession>
    <name>A0A151NMS7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RAB9B</name>
        <name evidence="18" type="ORF">Y1Q_0007259</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMS7"/>
    <dbReference type="STRING" id="8496.A0A151NMS7"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000360">
        <property type="entry name" value="RAB9B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF17">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO38142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="178" mass="20432" checksum="7084B79AD67D8D9F" modified="2016-06-08" version="1">MNRYVTNKFDSQAFHTIGVEFLNRDLEVDGRFVTLQIWDTAGQERFKSLRTPFYRGADCCLLTFSVDDRQSFENLGNWQKEFVYYADVKDPDRFPFVVLGNKIDKLDRQVTTEEAQAWCMENGNYPYLETSAKDDTNVAVAFEEAVRQVLAVEEQLEHCMLGHAIDLHSSSKSGSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRA7</accession>
    <name>A0A151NRA7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleophosmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NPM1</name>
        <name evidence="14" type="ORF">Y1Q_0004868</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoplasmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002337">
        <property type="protein sequence ID" value="KYO39240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRA7"/>
    <dbReference type="STRING" id="8496.A0A151NRA7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2100:FF:000001">
        <property type="entry name" value="Nucleophosmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.340:FF:000001">
        <property type="entry name" value="Nucleophosmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032569">
        <property type="entry name" value="NPM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004301">
        <property type="entry name" value="Nucleoplasmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024057">
        <property type="entry name" value="Nucleoplasmin_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747:SF28">
        <property type="entry name" value="NUCLEOPHOSMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747">
        <property type="entry name" value="NUCLEOPLASMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16276">
        <property type="entry name" value="NPM1-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03066">
        <property type="entry name" value="Nucleoplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nucleoplasmin core" evidence="12">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleophosmin C-terminal" evidence="13">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO39240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="255" mass="28023" checksum="DE36C114EE06ABF3" modified="2016-06-08" version="1">MEDSAMDVESMGPLRPQTFLFGCELKADKDFHFKVNDEENEHQLSLRTVSLGAGAKDELHVIEAEALDYEGNPIKATLASLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVYVSGQHLVALEEEPESDDEEDDVKMVNPLKRPAGGATVKTPQPARDSSAKNKQKSKQNGKDSKPSTPAKSNTPASNKKEKKPPTPKSPKGPLSLEEIKAKMQATLEKGTTLPKLEAKFVNYVKNCFRTQDQKVIQALWQWRQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRJ6</accession>
    <name>A0A151NRJ6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testis-expressed sequence 30 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TEX30</name>
        <name evidence="2" type="ORF">Y1Q_0021060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002195">
        <property type="protein sequence ID" value="KYO39404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266664.1">
        <property type="nucleotide sequence ID" value="XM_006266602.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRJ6"/>
    <dbReference type="STRING" id="8496.A0A151NRJ6"/>
    <dbReference type="GeneID" id="102569234"/>
    <dbReference type="KEGG" id="amj:102569234"/>
    <dbReference type="CTD" id="93081"/>
    <dbReference type="eggNOG" id="KOG3253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6415022at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NRJ6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046879">
        <property type="entry name" value="KANL3/Tex30_Abhydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF11">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20408">
        <property type="entry name" value="Abhydrolase_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANL3/Tex30 alpha/beta hydrolase-like" evidence="1">
        <location>
            <begin position="32"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="225" mass="25212" checksum="F3B16B644F1AD0E2" modified="2016-06-08" version="1">MGGYGEVKVKIPFGNKYLDAIFSVPERISTHGVILTHGAGGDMNFPHLVSLVTYLASHGVLCLRFTCKGLNITYRTKAYKRVVEYLKSCGEYTLSGVFLGGRSMGSRAAASVVRQISQDDSNDEFIQGLICLSYPLHRPKLQSKLRDEDLFFIRCPVLFVSGSEDEMCERKLLEGVASKIKVPKKIHWVDKANHGMSVKGRTADDVMMEINTEIFSWIQEIIEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTD9</accession>
    <name>A0A151NTD9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box/LRR-repeat protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FBXL4</name>
        <name evidence="4" type="ORF">Y1Q_0006581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002098">
        <property type="protein sequence ID" value="KYO40048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTD9"/>
    <dbReference type="STRING" id="8496.A0A151NTD9"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22117">
        <property type="entry name" value="F-box_FBXL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000050">
        <property type="entry name" value="F-box and leucine-rich repeat protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000628">
        <property type="entry name" value="F-box and leucine-rich repeat protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000152">
        <property type="entry name" value="F-box/LRR-repeat protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="246"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO40048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="590" mass="66769" checksum="A5E8FB742F860F4E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTS1</accession>
    <name>A0A151NTS1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002075">
        <property type="protein sequence ID" value="KYO40143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTS1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10495" checksum="E887449F6CB42B21" modified="2016-06-08" version="1">MDKTEPKYPTFSHGKSAAGFQYLQKVSGIYSPELKHQDSAGLLITSSCFQVPLGFIVHSCSLQHPNCFRFLVTAASSSKKNLMVWSSCIIMPEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUM3</accession>
    <name>A0A151NUM3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001930">
        <property type="protein sequence ID" value="KYO40360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUM3"/>
    <dbReference type="eggNOG" id="ENOG502SGKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="166" mass="19381" checksum="381F43F1BCFACBCA" modified="2016-06-08" version="1">MSSEQLFDIFCTDAVIRNKLEECTGIKMTATEWKFLEDQRSERKMYYEDVADTNELKAMERRRKVQCLDHFRKMAKDERAASESKETTYGSDVRSDEGTSVDELFPVEDEEDAPHFSLQGRRKRRYATRTLSSTTSASGTIPLECQHIRMSIRRVRPGFYETVDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWR0</accession>
    <name>A0A151NWR0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="19">1.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DUS3L</name>
        <name evidence="22" type="ORF">Y1Q_0011886</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266871.1">
        <property type="nucleotide sequence ID" value="XM_006266809.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWR0"/>
    <dbReference type="STRING" id="8496.A0A151NWR0"/>
    <dbReference type="GeneID" id="102560014"/>
    <dbReference type="KEGG" id="amj:102560014"/>
    <dbReference type="CTD" id="56931"/>
    <dbReference type="eggNOG" id="KOG2333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NWR0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000067">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000029">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 19" id="KW-0288">FMN</keyword>
    <keyword evidence="6 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="21">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="18">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="224"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO41173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="667" mass="74903" checksum="0B9499442E6ACA6C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWR6</accession>
    <name>A0A151NWR6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0012973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001744">
        <property type="protein sequence ID" value="KYO41019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWR6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016327">
        <property type="entry name" value="Alpha-defensin"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001875">
        <property type="entry name" value="Alpha-defensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0211">Defensin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586436" evidence="4">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO41019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="99" mass="11584" checksum="2C416EF1F5A4E2DB" modified="2016-06-08" version="1">MKFLYLLFGVAFLVLQTQAQDIQAQDKAEIQELNQLEAKVKLVVMETEHAADMKYLDPAQPRRRKFCSRQGVCKPRCSGNENSSRRCRNHQRCCVKRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX17</accession>
    <name>A0A151NX17_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly factor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COA5</name>
        <name evidence="5" type="ORF">Y1Q_0006253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in an early step of the mitochondrial complex IV assembly process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX17"/>
    <dbReference type="STRING" id="8496.A0A151NX17"/>
    <dbReference type="GeneID" id="102564024"/>
    <dbReference type="KEGG" id="amj:102564024"/>
    <dbReference type="eggNOG" id="KOG4114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NX17"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO41442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8688" checksum="E8A61CA083555F6C" modified="2016-06-08" version="1">MPKYYEGKEESGRPCSGFREDLQSCLLESDCVLKEGKSPKQCLKEGHCRSLQISFFECKRSTLDSRSRFRGRKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXL5</accession>
    <name>A0A151NXL5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Guanine nucleotide exchange factor DBS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0006171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MCF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXL5"/>
    <dbReference type="STRING" id="8496.A0A151NXL5"/>
    <dbReference type="eggNOG" id="KOG4240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01227">
        <property type="entry name" value="PH_Dbs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11857">
        <property type="entry name" value="SH3_DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035534">
        <property type="entry name" value="DBS_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035532">
        <property type="entry name" value="DBS_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF115">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="12">
        <location>
            <begin position="41"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="620"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="812"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1067"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="944"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO41329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1170" mass="133433" checksum="909A4AF30EE553CB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXN5</accession>
    <name>A0A151NXN5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dual specificity mitogen-activated protein kinase kinase 2</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ERK activator kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">MAPK/ERK kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MAP2K1</name>
        <name evidence="21" type="ORF">Y1Q_0011898</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXN5"/>
    <dbReference type="STRING" id="8496.A0A151NXN5"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090170">
        <property type="term" value="P:regulation of Golgi inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032872">
        <property type="term" value="P:regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06649">
        <property type="entry name" value="PKc_MEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000115">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000100">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF3">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="49"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO41185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="377" mass="42282" checksum="8B730FF954FC4462" modified="2016-06-08" version="1">MSWGNDARANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVELSIGRYPIPPPDSKELEAIFGRPVVDGAEGETHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPHGVFTQDFQEFVNKCLIKNPAERADLKMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZM6</accession>
    <name>A0A151NZM6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZM6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO42337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7627" checksum="6A1BA8335A86A92F" modified="2016-06-08" version="1">MPICMQPQCSTKQSQQCGALPPAAVRVKDTSCLPVCHFIVFTVYQTPEFEANTDSGNTCSATAFAQHEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZQ9</accession>
    <name>A0A151NZQ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Plectin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0006618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001523">
        <property type="protein sequence ID" value="KYO41905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZQ9"/>
    <dbReference type="STRING" id="8496.A0A151NZQ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000388">
        <property type="entry name" value="plectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF25">
        <property type="entry name" value="PLECTIN_ES10 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO41905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="176" mass="19577" checksum="EA477CEE6BF14501" modified="2016-06-08" version="1">MLMPLERLRAIYELLFREGVMVAKKDRRPHSFHPQLPGVSHLQVMRAMGSLKARGLVRETFAWRHAYWYLTDEGIAHLRQYLRLPPEIVPLSLQRVRRGPVPVPPSRRAAAAPRVQTVPGPLACPPKREEGWGARQAYRRKEEPPEPHVEPVAVGGVSQPAPQPSPGPGQPPAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P018</accession>
    <name>A0A151P018_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0002803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P018"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586530" evidence="2">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="119" mass="13026" checksum="081D31F669C18584" modified="2016-06-08" version="1">MGDTLSLLPQVLKLALGLLLLGKRKSSATKLYLHITEQPCGSYLPEDLVDHFPEAFLIAAVLGSWTARHYGIRLSRPADQGNSAANRRMQPKIVEPEAVESSPPAQHAKSKRLHCPSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P143</accession>
    <name>A0A151P143_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001351">
        <property type="protein sequence ID" value="KYO42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="108" mass="11495" checksum="0DE603F3296843CD" modified="2016-06-08" version="1">MATPPDTSPDKSDHAQGCCTTHEDSEPGQVGRKGAKINLMLSINFWTTSSLPAWHPKKEEGKASILGICQPDCSSASKRLLLISRSDQAAPLLGSRNNNHDSCCGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2F5</accession>
    <name>A0A151P2F5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein PTHB1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BBS9</name>
        <name evidence="8" type="ORF">Y1Q_0017554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2F5"/>
    <dbReference type="STRING" id="8496.A0A151P2F5"/>
    <dbReference type="eggNOG" id="KOG3679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028074">
        <property type="entry name" value="PHTB1_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055364">
        <property type="entry name" value="PTHB1_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055362">
        <property type="entry name" value="PTHB1_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23339">
        <property type="entry name" value="PTHB1_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14728">
        <property type="entry name" value="PTHB1_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23337">
        <property type="entry name" value="PTHB1_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 GAE" evidence="4">
        <location>
            <begin position="429"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 platform" evidence="5">
        <location>
            <begin position="519"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="6">
        <location>
            <begin position="628"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 C-terminal helix bundle" evidence="7">
        <location>
            <begin position="733"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO43241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="879" mass="98527" checksum="1C56BD0D03D8DB97" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2W2</accession>
    <name>A0A151P2W2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2W2"/>
    <dbReference type="STRING" id="8496.A0A151P2W2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="14387" checksum="87DC2D6D345C7331" modified="2016-06-08" version="1">MTWATFWDFLEQLQPHLEWQDTTMWVPLPTDTRLALALLQLAMPTSLRYVGHLFGVGKAILEVCSTLQDMPGHMVLCMHDPLVVGFCTLGFSQYIAALDRTHFPIICPLHGDHPYYSQRGFHSMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P366</accession>
    <name>A0A151P366_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Replication stress response regulator SDE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">SDE2</name>
        <name evidence="25" type="ORF">Y1Q_0013555</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content. May recruit CACTIN to the spliceosome.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor. Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014453661.1">
        <property type="nucleotide sequence ID" value="XM_014598175.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P366"/>
    <dbReference type="STRING" id="8496.A0A151P366"/>
    <dbReference type="GeneID" id="102561553"/>
    <dbReference type="KEGG" id="amj:102561553"/>
    <dbReference type="CTD" id="163859"/>
    <dbReference type="eggNOG" id="KOG2827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053821">
        <property type="entry name" value="Sde2_Ubi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22781">
        <property type="entry name" value="Sde2_N_Ubi_vert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Splicing regulator SDE2 ubiquitin" evidence="23">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="24">
        <location>
            <begin position="72"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2/SF3A3 SAP" evidence="22">
        <location>
            <begin position="320"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="170"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF22781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO43511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="397" mass="44135" checksum="26BDE1A010F39CB5" modified="2016-06-08" version="1">MVLLVRDPAASRARPLLLPDGGGLVRDLLRLRCRAQGIPEESVYVKCNGRLVNSEDELQDGAVYSLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWVKQQAEREAEKEQRRLERLQRKLAEPKHFFVNSDYQQQCNEMAERLEDSVLKGMQASSSKMVSPETSDSRKRPNESEKSGAKSEKRKCLWMGLEGLEDPESTDDSEDNYPSTAEGSCHSSSSHIEKTESTIEWPSSSEDSLGCSSTTNTSEKPQEQAEDAEKDLPEEVPTEEQIAIPTDEKNDTTETLKEEEQEKVSTTQEEIIPLQSTKSTPIDLLAFNSAAEMEALGLDKLKFELMALGLKCGGTLQERAARLFSVRGLPKDQIDPALFAKPSKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3A1</accession>
    <name>A0A151P3A1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3A1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045026">
        <property type="term" value="P:plasma membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060538">
        <property type="term" value="P:skeletal muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039014">
        <property type="entry name" value="Myomixer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41686">
        <property type="entry name" value="MYOMIXER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41686:SF1">
        <property type="entry name" value="PROTEIN MYOMIXER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21950">
        <property type="entry name" value="MINION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="12605" checksum="048505FFC475B24A" modified="2016-06-08" version="1">MCKNQHWGQQLHKKEPLGSFSGWLGERQLPEQGSLLLSLWQRPERSMPAPLLPLLLLLRTLGVRLLLLARQRLLPLLRRLRARLGSRESREALLACLLCILNLRKKVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3J8</accession>
    <name>A0A151P3J8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic AMP-dependent transcription factor ATF-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ATF3</name>
        <name evidence="4" type="ORF">Y1Q_0013637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3J8"/>
    <dbReference type="STRING" id="8496.A0A151P3J8"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14722">
        <property type="entry name" value="bZIP_ATF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000006">
        <property type="entry name" value="fos-related antigen 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF23">
        <property type="entry name" value="CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="125"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO43628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="220" mass="24827" checksum="405A7C53E451FB63" modified="2016-06-08" version="1">MQPRAEPESRGGASRQAGGTRSSLLAASPDLPGGPVPVPVPPPRTLRLVSEPALPCGGKQNDAPTPRPGFEDFTNLTPLVKEELRFAIQNKRQYHRMSSTLDTVTISERMVETSVLKAEFAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLETINAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P477</accession>
    <name>A0A151P477_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dual specificity protein phosphatase 10</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DUSP10</name>
        <name evidence="18" type="ORF">Y1Q_0013585</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer. Interacts with MAPK14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059573710.1">
        <property type="nucleotide sequence ID" value="XM_059717727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P477"/>
    <dbReference type="STRING" id="8496.A0A151P477"/>
    <dbReference type="GeneID" id="102559914"/>
    <dbReference type="KEGG" id="amj:102559914"/>
    <dbReference type="CTD" id="11221"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P477"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060284">
        <property type="term" value="P:regulation of cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14567">
        <property type="entry name" value="DSP_DUSP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000028">
        <property type="entry name" value="Dual specificity phosphatase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000013">
        <property type="entry name" value="Dual specificity phosphatase 10 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF299">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="17">
        <location>
            <begin position="166"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="318"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="381"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO43555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="479" mass="52470" checksum="DC82748578BF65C2" modified="2016-06-08" version="1">MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLESAASASESHASLLSTAVVSLKAANLTYMPSSNGSARSLSCGCSSASCCTVATYDKDNQAQTQASTSSTTNVGTSAPCPANQMVNNNENIGTLSPSGGVGSPASGTTKQLASIKIIYPNDLAKKMTKCTKSHQQNQGPVIIDCRPFMEYNKSHIQGAVHINCSDKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECPEGGGASAVAATLPQSIPTTPDIENAELTPILPFLFLGNEHDAQDLEKMQRMNIGYIINVTTHLPLYHYEKGMFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLIGVETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4D6</accession>
    <name>A0A151P4D6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4D6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO43615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="8114" checksum="E44DAB1AC9459D5D" modified="2016-06-08" version="1">MHSDSRLRTRQLMRRTQKSNVEQENLRDSAAVEAAHDKNIQLDKMHGKNHHELPQDTMSRQWTADVFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4S2</accession>
    <name>A0A151P4S2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GRIP and coiled-coil domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Golgi coiled-coil protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GCC1</name>
        <name evidence="13" type="ORF">Y1Q_0010035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probably involved in maintaining Golgi structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000999">
        <property type="protein sequence ID" value="KYO44003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4S2"/>
    <dbReference type="STRING" id="8496.A0A151P4S2"/>
    <dbReference type="eggNOG" id="ENOG502QQ2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.60:FF:000005">
        <property type="entry name" value="GRIP and coiled-coil domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="12">
        <location>
            <begin position="626"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="388"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO44003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="688" mass="77882" checksum="725D586A3B9F5DBB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4V6</accession>
    <name>A0A151P4V6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cathelicidin antimicrobial peptide preproprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CAMP</name>
        <name evidence="6" type="ORF">Y1Q_0006661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cathelicidin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000909">
        <property type="protein sequence ID" value="KYO44086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4V6"/>
    <dbReference type="STRING" id="8496.A0A151P4V6"/>
    <dbReference type="KEGG" id="amj:109282035"/>
    <dbReference type="OrthoDB" id="9930485at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000003">
        <property type="entry name" value="Cathelicidin antimicrobial peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001894">
        <property type="entry name" value="Cathelicidin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10206">
        <property type="entry name" value="CATHELICIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10206:SF0">
        <property type="entry name" value="CATHELICIDIN B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00666">
        <property type="entry name" value="Cathelicidins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO44086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="156" mass="17761" checksum="A98B4939C6E036D4" modified="2016-06-08" version="1">MLVASASASQHKMLSYEEAVSLAVDFYNQEPGIDHAFRLLRADPQPAWDMTSKPRQELQFVVRETVCPRAQDPPASECDFKDNGLVRNCTGLFSMERESPTVIITCDTVTPEQHVRVRRSGWWNRSKRRRGSGSRRGRFSHIAHGGRKGHERIARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P554</accession>
    <name>A0A151P554_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myotubularin-related protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MTMR14</name>
        <name evidence="1" type="ORF">Y1Q_0015221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000949">
        <property type="protein sequence ID" value="KYO44059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P554"/>
    <dbReference type="STRING" id="8496.A0A151P554"/>
    <dbReference type="eggNOG" id="ENOG502QQ9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13213">
        <property type="entry name" value="PH-GRAM_MTMR14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039802">
        <property type="entry name" value="MTMR14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039803">
        <property type="entry name" value="MTMR14_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524:SF2">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="354" mass="40153" checksum="081DBA6155DCAD71" modified="2016-06-08" version="1">MARCRGRFVCPVILYKGKHICRSATLAGWGELYGRTGYNYIFSGGSDDAWADTDDLSEEDPAFRNADSQLFDKVRGHDIKLLRYLSVRYICDLMVENKKVKFGLNVTSSEKVDKAQRYADFTLLSIPYPGCEFFKEYKDRDYTAEGLVFNWKQDYVDAPLSIPVSLTQALNIDWSEYQSWDLVQQTQNYLRLLISLINSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHASLEPAEILYLTVAYDWFLFGHMLADRLSKGEEIFFFCFNFLKHITSQEFSAAPPPRRKSLPPGFTLEEICMLQQRDRGSTTSLSSDFSLGVESSPGVVGSFTYEAVELMPAGAQAQAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5J5</accession>
    <name>A0A151P5J5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000840">
        <property type="protein sequence ID" value="KYO44209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5J5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="135" mass="15254" checksum="3A53B862039E91B4" modified="2016-06-08" version="1">MMCRVQRGDLIVCWRMEAQEDAGGKHNTALTRKKARVSSRACCIQGRPVQPRGLFVQGDNEISERDVVLNGTVEMWHLEKFPGSCYTLVSWSNEPSSPLNFRKHILVVHKKIWFLANAPSHPLGLTTKAMLEPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5W7</accession>
    <name>A0A151P5W7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox protein Nkx-3.1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NKX3-1-1</name>
        <name evidence="9" type="ORF">Y1Q_0016768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000764">
        <property type="protein sequence ID" value="KYO44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5W7"/>
    <dbReference type="STRING" id="8496.A0A151P5W7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF38">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-3.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="131"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="238" mass="26632" checksum="BFBF4E2EBC7DF362" modified="2016-06-08" version="1">MSAWVLPAGQQESESRPEPAQPKTSRPPMPLSSKPLTSFLIQDILGDGGARGRGCKPGRCCAACSPAAESRSAAALPPRDGRPASPGAPPGQARRHEKPRQHPGTDVHMESYLSDCESPLKSLPGTQRTQKQQKRSRTAFSHMQVIELKRKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRSVSKRRLRLSASPLLCTWYGARKQRLQLIILGNSVATYEEWGMWNLHFKDEFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5Y4</accession>
    <name>A0A151P5Y4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SNRPG</name>
        <name evidence="11" type="ORF">Y1Q_0013944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000870">
        <property type="protein sequence ID" value="KYO44135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014465292.1">
        <property type="nucleotide sequence ID" value="XM_014609806.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014465293.1">
        <property type="nucleotide sequence ID" value="XM_014609807.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014465295.1">
        <property type="nucleotide sequence ID" value="XM_014609809.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5Y4"/>
    <dbReference type="STRING" id="8496.A0A151P5Y4"/>
    <dbReference type="GeneID" id="106737822"/>
    <dbReference type="KEGG" id="amj:106737822"/>
    <dbReference type="CTD" id="6637"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000017">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO44135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8493" checksum="622646BB3EE758FE" modified="2016-06-08" version="1">MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMAQGGQQNNIGMVVIRGNSIIMLEALERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7J6</accession>
    <name>A0A151P7J6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0007317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7J6"/>
    <dbReference type="STRING" id="8496.A0A151P7J6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000013">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF27">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin tail" evidence="6">
        <location>
            <begin position="129"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="148"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="249"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO45002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="458" mass="52934" checksum="4E76E2BED0A74351" modified="2016-06-08" version="1">MKFQFEAKIKELNERLEDDEEMNTELTDKKRKLEDECSELKKDIDDIELTLAKFEKEKHATENKVKNVTEEMAVLDETTVKLTKEKKALQEAHQQVLDDLQVVEDKVSTLTKAKTKLEQQVDDVSMLYTREESGLQHKATVAALRKKHADSTAELMEQTDNLQRVKQKLEKEKSEMKMETDDLASNLETVIKAKANLEKMCRTLEDQLSERKAKFENQRHVNDLMMQRAHLQADSGQSSRQLEEKESIMSQLSRSKQAFTQQIEGLKRQLEEEVEAKNALAHGLQSACHDCDLLREEYEEEQETKKEIADVIEQIAENGKTIHELEKVKKQVEVEKCDMQMALEEAVNTSLINTKKKLEMDIVQIQSEIEDAIKDAKNAEENAKKAITDAAMMAEVLKKEQDIKAHLERMKKNMDQTVKDMQLCLDETEQLALKGGKKQIQKMEARVCVRQRCTTFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8V3</accession>
    <name>A0A151P8V3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8V3"/>
    <dbReference type="STRING" id="8496.A0A151P8V3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17211" checksum="F9E4F198FF5015EC" modified="2016-06-08" version="1">MAGSLTAPEIDDQLSTGQKENLRALISEFWEVFKELPEEAGVVEYQIQTPPGRIASNHWRRLPRHLWLAVRKEIDRMKRLGIIEESRSPWRSPMVVVPKLDGLIWLCIDYRKVNEIMTFNAFPMPQVDDMLEKAGQAWYIFTLDLTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAE0</accession>
    <name>A0A151PAE0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAE0"/>
    <dbReference type="eggNOG" id="ENOG502QQF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027871">
        <property type="entry name" value="DUF4603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611:SF3">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15376">
        <property type="entry name" value="DUF4603"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="579" mass="65042" checksum="07EEBEE4C651AB4B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PB19</accession>
    <name>A0A151PB19_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Vascular endothelial growth factor C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Flt4 ligand</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Vascular endothelial growth factor-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">VEGFC</name>
        <name evidence="22" type="ORF">Y1Q_0021711</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer; non-covalent and antiparallel. Interacts with FLT4/VEGFR3; the interaction is required for FLT4/VEGFR3 homodimarization and activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the PDGF/VEGF growth factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276984.1">
        <property type="nucleotide sequence ID" value="XM_006276922.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PB19"/>
    <dbReference type="STRING" id="8496.A0A151PB19"/>
    <dbReference type="GeneID" id="102571219"/>
    <dbReference type="KEGG" id="amj:102571219"/>
    <dbReference type="CTD" id="7424"/>
    <dbReference type="eggNOG" id="ENOG502QVXE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9981160at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PB19"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043185">
        <property type="term" value="F:vascular endothelial growth factor receptor 3 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050930">
        <property type="term" value="P:induction of positive chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001938">
        <property type="term" value="P:positive regulation of endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060754">
        <property type="term" value="P:positive regulation of mast cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002040">
        <property type="term" value="P:sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048010">
        <property type="term" value="P:vascular endothelial growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038084">
        <property type="term" value="P:vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00135">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000025">
        <property type="entry name" value="vascular endothelial growth factor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004153">
        <property type="entry name" value="CXCXC_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023581">
        <property type="entry name" value="PD_growth_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050507">
        <property type="entry name" value="PDGF/VEGF_growth_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12025">
        <property type="entry name" value="VASCULAR ENDOTHELIAL GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12025:SF3">
        <property type="entry name" value="VASCULAR ENDOTHELIAL GROWTH FACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03128">
        <property type="entry name" value="CXCXC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00141">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00249">
        <property type="entry name" value="PDGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-0497">Mitogen</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586858" description="Vascular endothelial growth factor C" evidence="20">
        <location>
            <begin position="25"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="21">
        <location>
            <begin position="111"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO46154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="414" mass="46788" checksum="AFFA625E99A0D660" modified="2016-06-08" version="1">MHLPGLCSLVCALLLGTRQPPAAAAYESGQGYYEEEPELGEAQAYANKDLEEQLRSVSSVDELMTVLYPEYWKMFKCQLRKGGWQHNREHSNFDTRTDDSIKFAAAHYNAEILKSIDNEWRKTQCMPREVCVDVGKEFGATTNTFFKPPCVSIYRCGGCCNSEGLQCMNISTSYISKTLFEITVPLSHGPKPVTVSFANHTSCRCMSKLDVYRQVHSIIRRSLPATQPQCHVANKTCPKNHIWNNHVCRCLAQHDFSFSSHLGDADTSEGFHICGPNKELDEETCQCVCKGGVRPSSCGSHKVLDRTSCQCMCKNKLLPSSCGPYKEFDEDKCQCVCKRACPKHQPLNPAKCVCECIETPNRCFLKGKRFHHQTCSCYRPPCTVRTKRCDPGFSYSEEVCRCVPTYWKRPLTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBG4</accession>
    <name>A0A151PBG4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0011418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000506">
        <property type="protein sequence ID" value="KYO46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBG4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00098">
        <property type="entry name" value="IgC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001774">
        <property type="entry name" value="Uncharacterized LOC100216153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="100"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="258"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="378"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="492" mass="54314" checksum="D24D2B6C260282A1" modified="2016-06-08" version="1">MEGTFPKDVAVTWERIHSKDRTVPESAGDQESPEHQPLYPALQLGWRVTEERAGTRLTSSLTFTPTLQDHGAQVRCVFLHKAKRIREERVSPEIRVWAQPQVSEIQVLPERDPCDKALVPGQPETLRCLISGFYPGQLAVTWLRKGAGEKAPRPLESSDPHRMHTPAPTRAPDGKSYSVESELRLPPAGPEDDGVEYLCRVQHEALKEPESRSSGRLRVQGSTKARPRDPRCLAGEEMATVGGQTDAWALRLGGLLLPLLFLGTAGSQLQVTTAPSSTARVGSGALLQCRFDVGGLVALDFLRVTWYFWEQKLAWYELGRSQDQPGASLPSEKELESGDASLSLAVATVSDEGLYRCVVGYGTQQRQGNTTLHLLAAPTISIPRKPVVADAETSLLCHVGRFFPEDVDVVWMRDGQVLKGSTRSSPHRNTDGTFNLTLTYTFTPTHSDASSIFSCRVRHDALEQPIQQDVPLDIRGEFPCPLPKVVQSCRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBH7</accession>
    <name>A0A151PBH7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Interferon-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IFI35</name>
        <name evidence="12" type="ORF">Y1Q_0018278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NMI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBH7"/>
    <dbReference type="STRING" id="8496.A0A151PBH7"/>
    <dbReference type="GeneID" id="102570485"/>
    <dbReference type="KEGG" id="amj:102570485"/>
    <dbReference type="CTD" id="3430"/>
    <dbReference type="eggNOG" id="ENOG502QUNN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9936051at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045088">
        <property type="term" value="P:regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000300">
        <property type="entry name" value="Interferon-induced protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009909">
        <property type="entry name" value="Nmi/IFP35_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225:SF1">
        <property type="entry name" value="INTERFERON-INDUCED 35 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15225">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07292">
        <property type="entry name" value="NID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="NID" evidence="11">
        <location>
            <begin position="172"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="NID" evidence="11">
        <location>
            <begin position="271"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO46467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="378" mass="43504" checksum="717C333936797E61" modified="2016-06-08" version="1">MTDLEESFVQLPDEDSLENIFLTMTPECIQKEIEKYKDRCFALEQDGADLKAAKEASEQKIQEFEKEAEHLCEKLEKDTLLSSELAASYQTKMHLAKEERYQLLQLKQKLEEELKELEKRRDAYNEQEKALPQVLPSLLERKMVFKGHMTREDTNSLAMTLLIQYPLPGGSALITFENPEVARRIMQKQEHEVELDECRVRVWAEPVELLLPSFLEIEMKRNSRRILVSNLPSLDLSEEQLLDKLELFFSKKKNGGGEVEWREFLSDTRHVVLSFMYDGVVEELIKKGHFQIQFGKTIHEVRVTPYVSGAIADLQFRPSICNRTVLLSGIPDVLDEEAMQDALEIHFQKPSQGGGEVDAISYVPAGKHGLAIFEEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCI8</accession>
    <name>A0A151PCI8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Keratin, type I cytoskeletal 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0018445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCI8"/>
    <dbReference type="STRING" id="8496.A0A151PCI8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF372">
        <property type="entry name" value="IF ROD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO46700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="274" mass="30373" checksum="3AED5C05DF49DB5C" modified="2016-06-08" version="1">MQNLNDRLASYLDKVRCLEEENAELECRIREWYTKHGPTCEPKDYSCYLREIEDLQNQIVCATIENNKIVLNIDNSRMAADDFRVKYETELSLLQSVEADINGLRQVLDQLTLCRSDLEAQLEALREELCCLKKNHEEEMNCLRKQSTGDVSVEQLAELRAEIECQNQEYKALLDVKCRLEQEIHTYCCLLEGGHREFSSKGVISSGGISSGGISSGISHSSGIGGGGICKSSGGIIGGGGIVKTIHTHSSSSHCLPSPCPPGDIKVPCRRLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCM0</accession>
    <name>A0A151PCM0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="35">ATP-dependent RNA helicase DHX58 isoform E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">DHX58</name>
        <name evidence="35" type="ORF">Y1Q_0018426</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="26 27">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PCM0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06481">
        <property type="entry name" value="ACD_HspB9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12090">
        <property type="entry name" value="MDA5_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000014">
        <property type="entry name" value="Histone acetyltransferase KAT2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009464">
        <property type="entry name" value="PCAF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06466">
        <property type="entry name" value="PCAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="18" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17 25" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 35" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="29">
        <location>
            <begin position="66"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="31">
        <location>
            <begin position="609"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="30">
        <location>
            <begin position="851"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="32">
        <location>
            <begin position="975"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="33">
        <location>
            <begin position="1315"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="34">
        <location>
            <begin position="1506"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1658"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KYO46674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1743" mass="197869" checksum="9ECC8CD21467E1DE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDW6</accession>
    <name>A0A151PDW6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0016214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000445">
        <property type="protein sequence ID" value="KYO47307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDW6"/>
    <dbReference type="eggNOG" id="ENOG502SJ0N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15421">
        <property type="entry name" value="7tmA_OR2T-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000008">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO47307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="256" mass="28672" checksum="82F0373EF4F3EB72" modified="2016-06-08" version="1">MYFFLCQLAFMDICQILIIVPKMLADFLIPGNPISPAGCGTQIFLMLTMGVSECLLLAVMSYDRYIAICNPLQYPILMNRNLCFVLSAGVWMGALVNALFHTVFTLDLPYCGSKEIDHFFCEVPALLKLSCSDTSQYETLVFVSSIVLLPIPSSIILASYACILSRVLRMKSTKGQQKALATCSSHLTVVGMFYGAAIFMYMRPGSYHSPEQDKIVSLFYTIVPPVLNPLIYSLRNRDVLRALRKLIGIFRVFLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEI2</accession>
    <name>A0A151PEI2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Synaptopodin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SYNPO2</name>
        <name evidence="7" type="ORF">Y1Q_0001228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptopodin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEI2"/>
    <dbReference type="STRING" id="8496.A0A151PEI2"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10820">
        <property type="entry name" value="PDZ_SYNPO2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000055">
        <property type="entry name" value="PDZ and LIM domain protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051976">
        <property type="entry name" value="Synaptopodin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217:SF9">
        <property type="entry name" value="SYNAPTOPODIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO47433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="944" mass="103270" checksum="1BAFD812F52FAF8A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFM7</accession>
    <name>A0A151PFM7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pleckstrin-like proteiny-like domain family A member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0019853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFM7"/>
    <dbReference type="eggNOG" id="ENOG502RZ5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042832">
        <property type="entry name" value="PHLA1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478:SF4">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15478">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO47792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="8047" checksum="F0A5BF0E3D835246" modified="2016-06-08" version="1">MKTVDCVERKGKYVYFTVVMAEGKEIDFRCPQEQGWNAEITLQLVQYKNRQAILAPAQVELKKPSRQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIS3</accession>
    <name>A0A151PIS3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000161">
        <property type="protein sequence ID" value="KYO48960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIS3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="157" mass="17572" checksum="D1510F1273DB379D" modified="2016-06-08" version="1">MHLALAPLGTGVLLNSNDRPNRRPTDKVGKHVLSVKTGTCYEEQSCSGRWFWGYKAKKKPCRWSDKKITPKNLASSCIIRGPSWLHHHFKITKDDKYKYPGILTPSWKFTLSALQVLRASGSSSSFCMIIQSLFILEMTSNSGSSPNDQESGVLAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZF5</accession>
    <name>A0A151LZF5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0011198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006911">
        <property type="protein sequence ID" value="KYO17628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZF5"/>
    <dbReference type="STRING" id="8496.A0A151LZF5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO17628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="81" mass="8542" checksum="9C34C3B709504E39" modified="2016-06-08" version="1">MHFHPKALKDVKGQVGAPMPGKVVDIKVAPGQVVAKGQPLCVLSAMKMETVVNCPVAGTVKAVHVQPDMSLEGDDLILEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZT0</accession>
    <name>A0A151LZT0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZT0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO17761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="107" mass="12090" checksum="87D84AD4686BAF78" modified="2016-06-08" version="1">MFTFLGKVITQLLKKGRKLQKQFVQDENEHSSLTDFRSSSVLQSLECLWDFNDLSCSSVMINVLETSRGTLMILEVKLDITQQKCLQTAISEITSKIMNAVLTTVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M269</accession>
    <name>A0A151M269_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M269"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="11367" checksum="C3E4084EAF1F85B0" modified="2016-06-08" version="1">MEEKCNRFRGWKCALTCWNRTKQWKLGATRSRAGERVTKDMETYLQKMEEPFHGAVKFHSCWDGDPPYEHVFVRKRKEDQNFFFFQEQPLRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3B9</accession>
    <name>A0A151M3B9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3B9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584708" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="7821" checksum="40A3ED32C5ED21A1" modified="2016-06-08" version="1">MLEESCGALSVLTLVGLLSPHVFVAGFMNDSCLLRLGGHGNHLHWLGSDAPVDSLAGTKYELPLELLEESVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3F8</accession>
    <name>A0A151M3F8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3F8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="12102" checksum="3B3EB0A0F5A469FB" modified="2016-06-08" version="1">MGGFSARDSPLLLAPANENLSFCSAGVSLGAESVQWYLPLSDHIVGATVRCLLKFPNQGLAAWMLGAGNNRQGDVRDHMLCVRALASCSQLLLLNYIPNPGCSYWILQYKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3R7</accession>
    <name>A0A151M3R7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0005033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006740">
        <property type="protein sequence ID" value="KYO19136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M3R7"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000005">
        <property type="entry name" value="Serine protease 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF81">
        <property type="entry name" value="GRANZYME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584733" description="Peptidase S1 domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO19136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="239" mass="26837" checksum="5A49303CDB67A205" modified="2016-06-08" version="1">MIQRKAIGKMLLLLLLPVALLLPSTLGDDKIIGGREAANDSHPYMASMNIEIFGLVRKRCAGFLIREDVVMTAAHCYVRFRDLNKISVVLGAHNVRKPGANSQKIDVRHQIVHPKYRRKTKHNDIMLLQLTQKAKLNDQVQLIGLPAKGEAVQPGTVCRVAGWDRTSLWNWKSLNVLLEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNIYQHHPISPSPCTSPAETNQTRVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M677</accession>
    <name>A0A151M677_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tenascin isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TNC</name>
        <name evidence="11" type="ORF">Y1Q_0013782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006441">
        <property type="protein sequence ID" value="KYO20023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M677"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000099">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000024">
        <property type="entry name" value="Tenascin-X"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF3">
        <property type="entry name" value="TENASCIN-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="141"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="241"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="338"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="440"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="533"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="648"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="741"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="840"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="930"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="1017"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="10">
        <location>
            <begin position="1103"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO20023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1319" mass="143919" checksum="A7E442637697130E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6B9</accession>
    <name>A0A151M6B9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6B9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="192" mass="21326" checksum="CA8B785080E939C6" modified="2016-06-08" version="1">MCLKQQPLNIRTTIAIGQAVKAIQVTGGSVAKVDMFIRDSPSSRDINRIGPKSLLSAQTTLALLISKLNSALKEASYAPALDVKSSSSDQNTCLTRDHQILLNPSKVFIISTVHKLQLQTELTAIFALKRSFTDSLPICCILRTEPRQDAWEHLNVYIHSRINQSRGWNFNLETAFPVACRRQKETTAKCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7A0</accession>
    <name>A0A151M7A0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MGAT4B</name>
        <name evidence="7" type="ORF">Y1Q_0010894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263584.1">
        <property type="nucleotide sequence ID" value="XM_006263522.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7A0"/>
    <dbReference type="STRING" id="8496.A0A151M7A0"/>
    <dbReference type="GeneID" id="102568458"/>
    <dbReference type="KEGG" id="amj:102568458"/>
    <dbReference type="CTD" id="11282"/>
    <dbReference type="eggNOG" id="ENOG502QPQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M7A0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584815" evidence="4">
        <location>
            <begin position="30"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 conserved region" evidence="5">
        <location>
            <begin position="110"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="6">
        <location>
            <begin position="399"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO20379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="546" mass="62942" checksum="68C7EEB3E7A5FBD0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7B6</accession>
    <name>A0A151M7B6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylsterol monooxygenase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0010858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7B6"/>
    <dbReference type="STRING" id="8496.A0A151M7B6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FA_hydroxylase"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="78"/>
            <end position="208"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO20330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="229" mass="27479" checksum="454A55556A29062D" modified="2016-06-08" version="1">MVRAVPTHCIRELDPDSQLDKPETWEDQWKCFKMTFYHIFTLHTPLSLAVYFYVEYANLPCDWNSMPRWYSAIAQVFGCLLIEDTWEYFTHRLLHHRRLYQYLHKVHHNFQTPFSIQATYAGPGEILIFGAGFSFGMYIFCNHLFSVWLCTVARIVQNTHVHSGYDAPWDPLRLVPFAVTSRFHDFHHMNFYGNYAPVFTWWDWLFGTNKAYQNYKARRKQKEIKEDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7P7</accession>
    <name>A0A151M7P7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7P7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="12810" checksum="31972B14FFEC0BB0" modified="2016-06-08" version="1">MYDQSKSPSADQEPPSLPHTTDKIKTWQDVVWSEEPVTAVSPDLILVEAISVFRKQLKRRVVLETRTNRILVKAYDPLPRVAEGREGDLLAPKQRFSEKNIVLHLNQTFVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7Q3</accession>
    <name>A0A151M7Q3_ALLMI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7Q3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="105" mass="11816" checksum="BC063A12D2C79171" modified="2016-06-08" version="1">MIWATLQELLIQLYPYLEQPTSTMWLSIPMDTQLAVAMFKLATPTSLHHVGHPFGLGKLITKKAILEVCGTLQDMLGHTVLRVHDLLEVMMEFCTLGFPSVIVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8B0</accession>
    <name>A0A151M8B0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8B0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="8077" checksum="8C63685544ABC830" modified="2016-06-08" version="1">MEEPCTGHWQLPLPGRNRGNCCRPTVKSNEELQSVPCGEAPYWRMNRYKFLRGQYTVHRCLLSLKRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9T1</accession>
    <name>A0A151M9T1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9T1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.70">
        <property type="entry name" value="Spindlin/Ssty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037656">
        <property type="entry name" value="DUF5525"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042567">
        <property type="entry name" value="SPIN/Ssty_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28422">
        <property type="entry name" value="SIMILAR TO HUMAN CHROMOSOME 15 OPEN READING FRAME 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28422:SF1">
        <property type="entry name" value="SIMILAR TO HUMAN CHROMOSOME 15 OPEN READING FRAME 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17663">
        <property type="entry name" value="DUF5525"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="776" mass="86435" checksum="566C301BD91C6D9E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAH8</accession>
    <name>A0A151MAH8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAH8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="94" mass="10490" checksum="715631DDD35E54C1" modified="2016-06-08" version="1">MNYSKHLKDMAHGPDTTQDRCRQPVPASVAGRVDVQGNRKGLKQLTRTVIAAGVRGNRKRREIVIILNKGILNSAPMDVTENGDQIEQGENRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MD47</accession>
    <name>A0A151MD47_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ephrin type-A receptor 3</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">EPH-like kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">Y1Q_0003034</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MD47"/>
    <dbReference type="STRING" id="8496.A0A151MD47"/>
    <dbReference type="KEGG" id="amj:102572251"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10481">
        <property type="entry name" value="EphR_LBD_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05066">
        <property type="entry name" value="PTKc_EphR_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09544">
        <property type="entry name" value="SAM_EPH-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000046">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000041">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000019">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000045">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034266">
        <property type="entry name" value="EphA3_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF12">
        <property type="entry name" value="EPHRIN TYPE-A RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00791">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 25" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585026" description="Ephrin type-A receptor 3" evidence="25">
        <location>
            <begin position="18"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="29">
        <location>
            <begin position="26"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="322"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="28">
        <location>
            <begin position="433"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="619"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="27">
        <location>
            <begin position="909"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="625"/>
            <end position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="68"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KYO22466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="981" mass="109629" checksum="22FDF2D5D1258CB7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDE1</accession>
    <name>A0A151MDE1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDE1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="90" mass="10104" checksum="16D36D9F700C68CD" modified="2016-06-08" version="1">MKWGQEQNFGCPPLVGRKSCAHPAVPTREVSVLNLRSASKGGVFDPSVFSTWSKSHQTTRLLLSPTLLSLQDQITVERSTQSWLVKHWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ME28</accession>
    <name>A0A151ME28_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 50B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM50B</name>
        <name evidence="7" type="ORF">Y1Q_0003270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259501.1">
        <property type="nucleotide sequence ID" value="XM_006259439.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331997.1">
        <property type="nucleotide sequence ID" value="XM_019476452.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ME28"/>
    <dbReference type="STRING" id="8496.A0A151ME28"/>
    <dbReference type="GeneID" id="102567434"/>
    <dbReference type="KEGG" id="amj:102567434"/>
    <dbReference type="CTD" id="757"/>
    <dbReference type="eggNOG" id="KOG3393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="PhylomeDB" id="A0A151ME28"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO22782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="158" mass="17893" checksum="BE46D950EE8E2C0A" modified="2016-06-08" version="1">MAGFLDNFRWPECECIDWSERRNTVASVVAGVLFFTGWWIMIDAAVVYPKPEQMNHAFHTCGVFSTLAFFMINAVSNAQVRGDSYGDGCLGRTGARVWLFIGFMLMFGSLIASMWILFGAYVTQNINVYPGLAVFFQNALIFFSTLIYKFGRTEELWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGX9</accession>
    <name>A0A151MGX9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGX9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="10840" checksum="012263E194B3B55F" modified="2016-06-08" version="1">MSVQASPLGNHLPFQANITVTVMEKKLKWTAYIIDVSFNNVKRGASENTNVTHGKIIVADQATQAVAAEDVKRNSHNLDTLLYNNYNEMMNAKTCISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MH33</accession>
    <name>A0A151MH33_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MH33"/>
    <dbReference type="eggNOG" id="ENOG502S5MZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="172" mass="18976" checksum="0A557DBEBC734E71" modified="2016-06-08" version="1">MEPEDIPDRDAGCWNANSSSCIFSHDCPPGTVQDFQKCKVATNQDRHVIERFKMDANREKEEATFGIPQAEEAWEDYMGFMRSAKLHMTEGLIVDIHGQAHPEQWIELGYTISKASLNSGLFSASGSSIQYLANQLGNVTFESLLRGHRSLGFNSEGPTSLGHGCGIQPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MI74</accession>
    <name>A0A151MI74_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0004275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MI74"/>
    <dbReference type="eggNOG" id="KOG4179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050211">
        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000048">
        <property type="entry name" value="Glycosyltransferase 25 family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF8">
        <property type="entry name" value="PROCOLLAGEN GALACTOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="6">
        <location>
            <begin position="371"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO24231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="655" mass="75423" checksum="377C113207D21E45" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MII3</accession>
    <name>A0A151MII3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM163A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FAM163A</name>
        <name evidence="6" type="ORF">Y1Q_0004315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM163 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MII3"/>
    <dbReference type="STRING" id="8496.A0A151MII3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029379">
        <property type="entry name" value="FAM163"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040281">
        <property type="entry name" value="FAM163A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31914">
        <property type="entry name" value="PROTEIN FAM163A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31914:SF2">
        <property type="entry name" value="PROTEIN FAM163A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15069">
        <property type="entry name" value="FAM163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO24283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="175" mass="19335" checksum="6D8F0A547057047F" modified="2016-06-08" version="1">MGGGAGKNTSTLGHVDLSTPVIFSQAYGTVTISAIFSSLMENRLQYYCCKKDEPEEEEEEEEEEPDLPTHSHFVTCNACNSRIMDGQGSPVPPPPELNQQGAHNYCPTCSPYGSPFYIRTADMVRNGGERITYTPTCYKEMGHPIKMATLQSYPVTHHGIVRETFPNPRAVSTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJW4</accession>
    <name>A0A151MJW4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Endothelial transcription factor GATA-2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GATA2</name>
        <name evidence="15" type="ORF">Y1Q_0023715</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJW4"/>
    <dbReference type="STRING" id="8496.A0A151MJW4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902895">
        <property type="term" value="P:positive regulation of miRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000001">
        <property type="entry name" value="GATA transcription factor (GATAd)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016374">
        <property type="entry name" value="TF_GATA-2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF149">
        <property type="entry name" value="ENDOTHELIAL TRANSCRIPTION FACTOR GATA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003027">
        <property type="entry name" value="TF_GATA-1/2/3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="183"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 1" evidence="11">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 2" evidence="11">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR003027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO24831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="374" mass="40260" checksum="6D4867736DE4B169" modified="2016-06-08" version="1">MEPAQLLPPDEVDVFFNHLDSQGNPYYPNSAHARARVSYSQAHARLTGGQMCRPHLLHSPGIPWLDSGKAALSAAHHHNPWTVGPFGKAPLHPSAAGAPGAISEVSPDPSSTSAASPSSSSAGARQEEKDSIKYQVSLADGMKMESASPLRSSLSSMGAQPSTHHPIPTYPFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGSECFEELSKCMQEKSSPFSAAALASHMAPMGHLPPFSHSGHILPTPTPIHPSSSISFGHPHPSSMVTAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLJ8</accession>
    <name>A0A151MLJ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0007226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005859">
        <property type="protein sequence ID" value="KYO25323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLJ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="3">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO25323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="177" mass="19903" checksum="562755952DED8890" modified="2016-06-08" version="1">MQKGDRSPAKCRMPDIWDHQAEFTPKQLSYNPGDVVTWSCPKSYWPSLVKTRCMQSGNWNPRGVHCNGFCTIGGNWPPSISTESMQTEFPVGQMVWVTCRPEQFEGGTFRVWCVDRAGHPEWDTQHVNCIAVPMVSVPGLLECLTWEPGAPNKTSQPDQPVKLFVTLRSAPAELPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MM87</accession>
    <name>A0A151MM87_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005690">
        <property type="protein sequence ID" value="KYO25645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MM87"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="185" mass="19683" checksum="59D398AFF78E4FA8" modified="2016-06-08" version="1">MRTENPLLFSKHCEKPITLSGRAWAVLCDSTGVSPARWSGPARPRAPGAACGRGSLLTRVVASKASPCAPVLGNQLIGGEVKRDIWHRKTWGRMAPDSCQVCSVSLCGLLRNRRRVGYPGAPRAEEESCHVCKGHSGQSDGCAVLWQSLEAAKAPHVTVSARRYSVTEVGLGNIQGTTGNSFSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MML5</accession>
    <name>A0A151MML5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MML5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9286" checksum="9DE5491AA65ED3B5" modified="2016-06-08" version="1">MSQLYIVHLGSNFSRLAKGNINKPPILVKESSWTGIMASNSIFDTFATYSPTFLRELPSEDLGRLYIRLSLAGLIQRDLSGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNI2</accession>
    <name>A0A151MNI2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ganglioside-induced differentiation-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GDAP1</name>
        <name evidence="21" type="ORF">Y1Q_0003741</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Regulates the mitochondrial network by promoting mitochondrial fission.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261615.2">
        <property type="nucleotide sequence ID" value="XM_006261553.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNI2"/>
    <dbReference type="STRING" id="8496.A0A151MNI2"/>
    <dbReference type="GeneID" id="102567592"/>
    <dbReference type="KEGG" id="amj:102567592"/>
    <dbReference type="CTD" id="54332"/>
    <dbReference type="eggNOG" id="KOG4420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MNI2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10303">
        <property type="entry name" value="GST_C_GDAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03052">
        <property type="entry name" value="GST_N_GDAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000022">
        <property type="entry name" value="ganglioside-induced differentiation-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000113">
        <property type="entry name" value="ganglioside-induced differentiation-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034336">
        <property type="entry name" value="GST_C_GDAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44188:SF3">
        <property type="entry name" value="GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44188">
        <property type="entry name" value="GDAP1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="19">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="20">
        <location>
            <begin position="149"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="149"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO25960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="350" mass="40193" checksum="9D61CCB781310ADC" modified="2016-06-08" version="1">MALAGDGEGPQPEPEPTLVLYHWTQSFSSQKVRLVIAEKALKCKEHDVNLPLSEHNEPWFMRLNSSGEVPVLIHGENIICEATQIIDYLESTFVNEKTPRLMPEDGSMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSLIPAYATTRIRSQISNTESELKKLAEENPDLQDAYIAKQKRLKSKLLDHDNIKYLKKILDELEKVLDQVETELQRRNEETPEEGHQPWLCGEFFSLADVSLAVTLHRLKFLGLARRNWGNGKRPNLEAYYERVLKRKTFNKVLGHVNNILISAVLPTAFRVAKKRAPKVLGSTLLVGFLAGMGYLAFMCLRKRFANMMLSIRTRQNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MP77</accession>
    <name>A0A151MP77_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serpin B11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SERPINB11</name>
        <name evidence="7" type="ORF">Y1Q_0002029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serpin family. Ov-serpin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005656">
        <property type="protein sequence ID" value="KYO26229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MP77"/>
    <dbReference type="STRING" id="8496.A0A151MP77"/>
    <dbReference type="eggNOG" id="KOG2392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19956">
        <property type="entry name" value="serpinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000004">
        <property type="entry name" value="Serpin family B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000014">
        <property type="entry name" value="Serpin family B member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF199">
        <property type="entry name" value="SERPIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="39"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO26229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="423" mass="47679" checksum="DB934AEB2AB9020D" modified="2016-06-08" version="1">MSLIATAATGDTRILIHVHRCFTVFTMASLSEANAEFCLDFFKEVKKTERNENIFFSPLSISSAMAMVLLGARGNTAKQMEKVLHFDEVLSSSGGSTNDGSSECEDGGVHSQFQALLSAINKPTDDYSLRIANRLYGAKDFNFLQQYLKCTETLYHAELEAVDFRNALEETRKKINTWVEKQTNGKIKELFAEHALGSDAILVLVNAIYFKGMWTVQFKKEDTKEEPFRLNKNQTKNVQMMFQKNEYNLAIIEEPEIQVLELPYGKEKELSMFILLPKDIKDNSTGLEQLESALTYKNLQEWTSLAKMQKQSVSVYLPQFRMEKSYGLDRILAAMGMLELFDSSKADLSGISRNRDVFMSAAIHKSYVEVNEEGTEAAAVTGGVIGTTSVKIPYEFKADHPFLFFIKHCGTNSILFYGQCTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQ39</accession>
    <name>A0A151MQ39_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Macrophage mannose receptor 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0019085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000014">
        <property type="entry name" value="Macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000016">
        <property type="entry name" value="macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000023">
        <property type="entry name" value="Macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000031">
        <property type="entry name" value="macrophage mannose receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000022">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000025">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000030">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000027">
        <property type="entry name" value="Mannose receptor, C type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1339"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="11">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="185"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="328"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="470"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="614"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="765"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="909"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO26593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1406" mass="160658" checksum="312A9D6A1790DEB9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRX1</accession>
    <name>A0A151MRX1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0021212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03005226">
        <property type="protein sequence ID" value="KYO27276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRX1"/>
    <dbReference type="STRING" id="8496.A0A151MRX1"/>
    <dbReference type="eggNOG" id="KOG3002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Seven-in-absentia protein TRAF-like" evidence="6">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO27276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="120" mass="13371" checksum="F91ED50A3FA76E39" modified="2016-06-08" version="1">MAVSSLLTKVVGEIQGEEMSRQTATALPTVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSN4</accession>
    <name>A0A151MSN4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adhesion G protein-coupled receptor G3 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ADGRG3</name>
        <name evidence="10" type="ORF">Y1Q_0003642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSN4"/>
    <dbReference type="STRING" id="8496.A0A151MSN4"/>
    <dbReference type="KEGG" id="amj:106738830"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15442">
        <property type="entry name" value="7tmB2_GPR97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000222">
        <property type="entry name" value="Adhesion G protein-coupled receptor G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF285">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585415" evidence="7">
        <location>
            <begin position="29"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="8">
        <location>
            <begin position="122"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="277"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO27469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="572" mass="64327" checksum="E77510C128A86C17" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MT06</accession>
    <name>A0A151MT06_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MT06"/>
    <dbReference type="STRING" id="8496.A0A151MT06"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="219" mass="24302" checksum="947286149C440615" modified="2016-06-08" version="1">MLEQMGVPLTFIGWIWTLYMEVSSKVQISGFLSTWIVVEPRVRQGCPLSLILFTFTIEPLAQCLRQDPGIHGLHNPGSSNCKAKVLAYLDYLNILCWNRGSVERALVNMQVYEALVGAKLNVSKSTCLAVGEVRDLESLGVSVPHEGVRILRIDFNPELSGRTAWESTEAKPLVHFELKTTIVLSSGEGGLHSSGRCLQEWLCCPVLQKDSNDVTVQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTX0</accession>
    <name>A0A151MTX0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Heterogeneous nuclear ribonucleoprotein R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HNRNPR</name>
        <name evidence="20" type="ORF">Y1Q_0014171</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO27971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTX0"/>
    <dbReference type="STRING" id="8496.A0A151MTX0"/>
    <dbReference type="eggNOG" id="KOG0117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21066">
        <property type="entry name" value="NURR_hnRNPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12483">
        <property type="entry name" value="RRM1_hnRNPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12489">
        <property type="entry name" value="RRM2_hnRNPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12495">
        <property type="entry name" value="RRM3_hnRNPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000023">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000024">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000027">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041337">
        <property type="entry name" value="hnRNP_Q_AcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034544">
        <property type="entry name" value="hnRNPQ_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034548">
        <property type="entry name" value="hnRNPQ_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18360">
        <property type="entry name" value="hnRNP_Q_AcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="16 20" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="181"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="262"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="357"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="516"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO27971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="581" mass="64579" checksum="FBE4C4F6E96F36EB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUQ7</accession>
    <name>A0A151MUQ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Ras-related protein Rab-34</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">RAB34</name>
        <name evidence="29" type="ORF">Y1Q_0023098</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="27">Interacts with RILP. The GTP-bound form interacts with REP15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Phagosome membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03004952">
        <property type="protein sequence ID" value="KYO28250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014460257.2">
        <property type="nucleotide sequence ID" value="XM_014604771.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUQ7"/>
    <dbReference type="STRING" id="8496.A0A151MUQ7"/>
    <dbReference type="GeneID" id="102572661"/>
    <dbReference type="KEGG" id="amj:102572661"/>
    <dbReference type="CTD" id="83871"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413584at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MUQ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04108">
        <property type="entry name" value="Rab36_Rab34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000748">
        <property type="entry name" value="ras-related protein Rab-34 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="22" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="25" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="21" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="23" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00062850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00067829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KYO28250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="259" mass="28944" checksum="FE58E231B1B8DEA0" modified="2016-06-08" version="1">MSVLAPVRRDRVVAELPQCFRKEAALHARTAFHPSVTSACQEQRTGTVGFKISKIIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFKCIASTYYRGAQAIVIVFDVNNVASLEHTRQWLADALKENDPANVLLFLVGSKKDLSPPARYSLAEKDALKVAQEMRAEYWAVSSLTGENVREFFFRVAALTFESSVLAELERSSARKIGDVVRISSNDSDVYLTAQGKKPKCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV78</accession>
    <name>A0A151MV78_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-coenzyme A thioesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ACOT4</name>
        <name evidence="3" type="ORF">Y1Q_0016023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV78"/>
    <dbReference type="STRING" id="8496.A0A151MV78"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000024">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF17">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="2">
        <location>
            <begin position="162"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO28446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="378" mass="41633" checksum="5793D35F915C63BE" modified="2016-06-08" version="1">MGAPRVRLVPGGRSLWDEPLGLAVEGLGPRQEVTLRAALQDEAGEDFEARLLKRDVRSPFRLRLDVLEGHGPLPGRLLARAEHERCFLGPGVARLPLRHGRLRATLFLPPGDGPFPGIIDLYGTGGGLPEYRACLLANHGFATLALAYYNYEDLPKEMTEFHLEYFEEAVNYMLEHPQVKGPGVGLLGISKGGELCVSMASFLKGITATVVINGAVANVGAVLRYKDITIPPLGFDRKRLKIDKSGLVDIVDTLNNPLEGPNQQSLIPLEKADSCFLFIVGKDDRNWRSEFFAIEGAKRLLAHGKEKPEIICYEGAGHYIEPPYFPMCEASMHLLVGSTVIWGGEPKAHSEAQVDAWQKIQAFFHKYLSSNQSEPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVG5</accession>
    <name>A0A151MVG5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Haptoglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HP</name>
        <name evidence="9" type="ORF">Y1Q_0016311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004908">
        <property type="protein sequence ID" value="KYO28477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVG5"/>
    <dbReference type="STRING" id="8496.A0A151MVG5"/>
    <dbReference type="GeneID" id="106737681"/>
    <dbReference type="OrthoDB" id="6339452at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585484" evidence="7">
        <location>
            <begin position="18"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="41"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO28477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="307" mass="32483" checksum="B72E18821CE7149A" modified="2016-06-08" version="1">MGAPMLLIATLVWGVLATASEGPDTQACGKPKNSPQPLQRIIGGRMSGKGLFPWQGRLVSPHNLTAGATLISDQWVLTTARNVYLGQNACASPEDIAPTLKLFLGNRGQLPAGAVERVVLHPNFNSTDCNATSHCNATSNCNATSNCHAAPGTGTDLALLKLQHPAPLGPEVLPICLPQKDFLEVGRVGYVAGWGRGATLAFAEWLRYIMVPVADTSLCAKYYADGGPIGVAPDLGPDSFCVGMSKLREDTCHGDAGGAFAVHDPDDDTWYAAGILTYDRTCSAAKYSVYASVQHALAWIRQTMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVJ6</accession>
    <name>A0A151MVJ6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Melatonin receptor type 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MTNR1B</name>
        <name evidence="15" type="ORF">Y1Q_0005321</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004889">
        <property type="protein sequence ID" value="KYO28515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MVJ6"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904408">
        <property type="term" value="F:melatonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008502">
        <property type="term" value="F:melatonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046325">
        <property type="term" value="P:negative regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000056">
        <property type="entry name" value="Melatonin receptor type 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002278">
        <property type="entry name" value="Mel_1A/1B_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000025">
        <property type="entry name" value="Melatonin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF54">
        <property type="entry name" value="MELATONIN RECEPTOR TYPE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01149">
        <property type="entry name" value="MELATONIN1AR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00857">
        <property type="entry name" value="MELATONINR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="32"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO28515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="338" mass="38343" checksum="C499FB74BD3DEB87" modified="2016-06-08" version="1">MLDNGSLRXXXXWVVAALSGVLIFTTVVDIVGSLLVVVSVFKNRKLRNSGNAFVVSLALADLVVALYPYPLVLFAIFHNGWTLGEMHCKVSGFVMGLSVIGSIFNITAIAINRYCYICHSFAYDKVYSCWNTMLYVCLIWLLTIIATVPNFFVGSLEYDPRIYSCTFVQTASSYYTIVVVVIHFIVPISIVSFCYLRIWILVIHVKRRVKSETKPGLKPSDFRNFLTMFVVFVIFAFCWAPLNFIGLAVAINPLEMGPKIPEWLFIVSYFMAYFNSCLNAIIYGLLNQNFRKEYKQILMSLWMPRIFYQETSKGGTDGQRSKPSPALNNNDQVKTDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVT4</accession>
    <name>A0A151MVT4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004889">
        <property type="protein sequence ID" value="KYO28549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVT4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="140" mass="16202" checksum="680F026DB96632B2" modified="2016-06-08" version="1">MMMCGCRPMPNANKHPRVDAVMLVTTGLLLTDHCHRVLGTAIVFLTQAQISITLQRRHLVSGWEFTHLRAEPRLPSRQAKYRPIVTPCELPMRWPEEVKSPPAYKKYHWASQATSDRLGFNYMVPSHQTWQASYDPRTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWE0</accession>
    <name>A0A151MWE0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC84</name>
        <name evidence="2" type="ORF">Y1Q_0008118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004743">
        <property type="protein sequence ID" value="KYO28807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWE0"/>
    <dbReference type="STRING" id="8496.A0A151MWE0"/>
    <dbReference type="eggNOG" id="ENOG502QS8B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028015">
        <property type="entry name" value="CCDC84-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31198:SF1">
        <property type="entry name" value="CENTROSOMAL AT-AC SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31198">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14968">
        <property type="entry name" value="CCDC84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="252" mass="28899" checksum="B4D8FC09900B45CF" modified="2016-06-08" version="1">MVWKLSAEHRSAAHRFWWENKAEPKLKHHFLVSPQDYTRFKSSLVKALDAYEEKEDKTIEEMASRIREVEESRRQLVQAALEPEKETEPCDGPSVFSAPGVSESDITCCTNEQPGPSGMQPLSDLDWMEKGHALTFIGHQETGGKGNIHTGAKPPWLVQDEEEVAGNKQQIGPSYEEFLKEKEKQKLKKLPAERVGANFDHTSQTGEGWLPSFGRVWNHGRRWQSRHQFKAEAGKKTDRQRRNTRRPKSEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWE9</accession>
    <name>A0A151MWE9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWE9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10269" checksum="02302BDC21BE9D5A" modified="2016-06-08" version="1">MDGKKGAERGDAIHTKRSIRYKSTVPVKEAACKSLPETFLMEMVYKVKANRLLKWKMASMTRGRSIFFPSCKINSSYFGVSSCVRSNIEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWJ0</accession>
    <name>A0A151MWJ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding E3 ubiquitin-protein ligase MEX3C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEX3C</name>
        <name evidence="9" type="ORF">Y1Q_0009749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWJ0"/>
    <dbReference type="STRING" id="8496.A0A151MWJ0"/>
    <dbReference type="eggNOG" id="KOG2113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22424">
        <property type="entry name" value="KH-I_MEX3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16722">
        <property type="entry name" value="RING-HC_MEX3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000013">
        <property type="entry name" value="Mex-3 RNA-binding family member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000090">
        <property type="entry name" value="Mex-3 RNA-binding family member C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047226">
        <property type="entry name" value="KH-I_MEX3_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047227">
        <property type="entry name" value="MEX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23285">
        <property type="entry name" value="RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23285:SF8">
        <property type="entry name" value="RNA-BINDING E3 UBIQUITIN-PROTEIN LIGASE MEX3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="321"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO28906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="366" mass="39678" checksum="9FC2FEF203C56DCA" modified="2016-06-08" version="1">MAKREILSAAEHFSMIRASRNKNGPALGGLPCTPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLTSNPVPPSRTRMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGETLPPVGTEDLAVDSPAYDSLPTPSQTIWTPFEPVNPLSGFGGDPTGNMKTQRRGSQPSTPRLSPTFPETLEHPLGRRLRNDPPGTGNQAGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKETPSCPVCQTAVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXG2</accession>
    <name>A0A151MXG2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing regulatory glutamine/lysine-rich protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Serine/arginine-rich-splicing regulatory protein 86</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Splicing factor, arginine/serine-rich 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SREK1</name>
        <name evidence="15" type="ORF">Y1Q_0009966</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449580.1">
        <property type="nucleotide sequence ID" value="XM_014594094.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXG2"/>
    <dbReference type="STRING" id="8496.A0A151MXG2"/>
    <dbReference type="GeneID" id="102558828"/>
    <dbReference type="KEGG" id="amj:102558828"/>
    <dbReference type="CTD" id="140890"/>
    <dbReference type="eggNOG" id="KOG4676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12519">
        <property type="entry name" value="RRM1_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12260">
        <property type="entry name" value="RRM2_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000084">
        <property type="entry name" value="Serine/arginine-rich splicing factor 11 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000142">
        <property type="entry name" value="splicing regulatory glutamine/lysine-rich protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034192">
        <property type="entry name" value="SREK1_RRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF71">
        <property type="entry name" value="SPLICING REGULATORY GLUTAMIC ACID AND LYSINE RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="182"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="289"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="320"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="376"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="630"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO29194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="695" mass="79912" checksum="34D1C0E6212ADE80" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXG8</accession>
    <name>A0A151MXG8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXG8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="166" mass="18529" checksum="3FDE35660AB409C5" modified="2016-06-08" version="1">MLDTEGEDISEGAEALLDNTFLMRPVTLVLEKRNCFCDKQSLSRADRVLRELLIRKIANTSNFSHGEKKYLPPGGQSASQQSQDLSSEKATDALRKLTSERNSYSKRKIRTHMYLCLYPVVKATPKGKSEHTCTSMSLPCSESNTSKGGDVPENRLPETLKSQESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXW6</accession>
    <name>A0A151MXW6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen triple helix repeat-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CTHRC1</name>
        <name evidence="4" type="ORF">Y1Q_0017983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006277396.1">
        <property type="nucleotide sequence ID" value="XM_006277334.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXW6"/>
    <dbReference type="GeneID" id="102573923"/>
    <dbReference type="KEGG" id="amj:102573923"/>
    <dbReference type="CTD" id="115908"/>
    <dbReference type="eggNOG" id="ENOG502QSJD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5985978at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MXW6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057873">
        <property type="entry name" value="CTHRC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25815">
        <property type="entry name" value="CTHRC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585566" evidence="2">
        <location>
            <begin position="31"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CTHRC1 C-terminal" evidence="3">
        <location>
            <begin position="97"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO29350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="239" mass="25486" checksum="30FD2865383822E1" modified="2016-06-08" version="1">MRCPPAAAASRLFPAALLLLLLAAPGGSDSAKAKQKAPRQREVLDVYNGMCLQGPGGVPGRDGSPGINGIPGTPGIPGRDGLKGEKGDCMRESIEESWTPNFKQCSWSALNYGIDLGKIAECTFTKMRSNSALRVLFSGSLRLKCKSACCQRWYFTFNGAECSGPLPIEAIIYLDQGSPELNSTINIHRTSSVEGLCEGINAGLVDVAIWVGTCSDYPRGDASTGWNSVSRIIIEEMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYI3</accession>
    <name>A0A151MYI3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA excision repair protein ERCC-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ERCC1</name>
        <name evidence="11" type="ORF">Y1Q_0017667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004613">
        <property type="protein sequence ID" value="KYO29623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006265865.2">
        <property type="nucleotide sequence ID" value="XM_006265803.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYI3"/>
    <dbReference type="STRING" id="8496.A0A151MYI3"/>
    <dbReference type="GeneID" id="102571565"/>
    <dbReference type="KEGG" id="amj:102571565"/>
    <dbReference type="CTD" id="2067"/>
    <dbReference type="eggNOG" id="KOG2841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000017">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="10">
        <location>
            <begin position="118"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO29623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="329" mass="35462" checksum="CC3378383DF2724B" modified="2016-06-08" version="1">MEPGQAPGGRRKFAVPTPSEEPEAPLVRPFFKSFAAAPPPAEPGAPSPPGPSSYADYVVKQAATARAAPATALASKQGAAPEPPSPAATHSTEGCEGGPGPGHVAPSPTVKPGVRSSSIIVRPCQRGNPVLKFVRNVPWEFGDVVPDYVLGQSTCALFLSLRYHNLKPDYIHERLRCLGRTFALQILLLQVDVKDPHKALKELAKICILADCTLVLAWSPEEAGRYLETYKAYEQKPPDLLMEKVDQDFLSQMTNCLTSVKSVNKTNTLSLLSAFGSLASITQASREDLSLCPGIGPQKAKRLFDVLHEPFLKVPRQAEPSLPRGLDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZ95</accession>
    <name>A0A151MZ95_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0018548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03004460">
        <property type="protein sequence ID" value="KYO29886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZ95"/>
    <dbReference type="STRING" id="8496.A0A151MZ95"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="192"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO29886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="342" mass="38917" checksum="D4C80BAADB86B314" modified="2016-06-08" version="1">MRKVERDSLGQAQEKQRSWYDEKARLRTFERGENVMVFLPLKTDKLQGAREGPHAVLDRLDDVNYVVAIRDRKPKTVHVNMLKPYYDRKEMVFWVPSIEGTPEGLEEPVMYGDWDDEAGIEELRLLHHLPSQNKDQLLAALKDFETVFSNKPGKTDLAVHSIETGSHRPIYSRHYPVNEVRQEIKREIAEMEELGVIRPSTSPSASPVVLVRKQDGIIRFCVDYRKLNAITTPDAYPMPRMDTLLGRLGPAKVTSTLDLSKGFWQMALDPDAIAKSAFTTPTGLYEFTVLPFGLCNSSASFQRLINNLLQGCEQFAMAYIDDIAIFSPDFESQLTHLTTVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZZ4</accession>
    <name>A0A151MZZ4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Perilipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0016595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004311">
        <property type="protein sequence ID" value="KYO30146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZZ4"/>
    <dbReference type="STRING" id="8496.A0A151MZZ4"/>
    <dbReference type="eggNOG" id="ENOG502R7TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.170">
        <property type="entry name" value="Perilipin, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF11">
        <property type="entry name" value="PERILIPIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO30146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="388" mass="41339" checksum="3245D85192263F56" modified="2016-06-08" version="1">MTSPKPSKASPNEPDMKPEPELEPEQQNLASRVASLPLVSSAYDMVSAAYASTKDSHPYMRSVCDVAEKGVKTLGAVAASGAQPLLAKLEPQISTANDYACKGLDKLEETLPILQQPTDKILSDTKELVTSTVTGAKDALSSSVSAVSSRVTGAVDLTKGAVQGGVELTRAAVASGVSTVMGSAMGQMVASGMGAVLGKSEELVDHYLPMTDEELANLATAVEGFDVASVEQQKQQQSYFVRLGSLSSKLRHRAYQQSLGKLRRIRQSTQEGLGKLHHTIELMEHVKQGVDQKVQGGREKLHQMWLEWRQTQLGAGQDKEADSKVVMAEQPEQVESLALAMSRGLTQQLQAASQTLASSLQGLPAGIQDKVVQATKMLLKLMLGSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N221</accession>
    <name>A0A151N221_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0008316</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with PPP1CA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N221"/>
    <dbReference type="STRING" id="8496.A0A151N221"/>
    <dbReference type="eggNOG" id="ENOG502QVFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000047">
        <property type="entry name" value="protein phosphatase 1 regulatory subunit 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055106">
        <property type="entry name" value="ELFN_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF204">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22986">
        <property type="entry name" value="Fn3_ELFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="14">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="590"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="781" mass="88358" checksum="AD16BD619A79D855" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2A0</accession>
    <name>A0A151N2A0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FAM104A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM104A</name>
        <name evidence="2" type="ORF">Y1Q_0016317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2A0"/>
    <dbReference type="STRING" id="8496.A0A151N2A0"/>
    <dbReference type="eggNOG" id="ENOG502S0Z3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029222">
        <property type="entry name" value="VCF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34763">
        <property type="entry name" value="PROTEIN FAM104A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34763:SF1">
        <property type="entry name" value="PROTEIN FAM104A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15434">
        <property type="entry name" value="FAM104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="77" mass="8789" checksum="F28878D0D8227411" modified="2016-06-08" version="1">MSCRQPLPSERGARQRKRRRNGNEEDGHIPQTKRSTRNAVLQDSWDTEKVPVTKNSKETRLKGNKVSCAVGFSPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5I3</accession>
    <name>A0A151N5I3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear pore complex protein Nup88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NUP88</name>
        <name evidence="9" type="ORF">Y1Q_0007047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5I3"/>
    <dbReference type="STRING" id="8496.A0A151N5I3"/>
    <dbReference type="eggNOG" id="KOG4460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="476"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO32021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="612" mass="69216" checksum="343965C6B3D30EEB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7G1</accession>
    <name>A0A151N7G1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7G1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="11949" checksum="BEACBF1B6ECF8FEE" modified="2016-06-08" version="1">MPRSGASRSIPALKKNSGAWKRDRVITDGLERIPFETEVKLCPKGVMFAEQTDASLHPVKVLRKEEEDSMIPSHHMARKNLKDTQKYQAYLHHLLCQHKQVSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7R4</accession>
    <name>A0A151N7R4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7R4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8288" checksum="229F64B4D0A3C480" modified="2016-06-08" version="1">MSRDNRELLALLPKIAGQGEDLEKDWPESAPGISSLPSLLDFLHSPSNLPWKDAACDGNRGWTANGDPTKIWARGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7U3</accession>
    <name>A0A151N7U3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003838">
        <property type="protein sequence ID" value="KYO32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7U3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="12707" checksum="5EC96B2EF8C61355" modified="2016-06-08" version="1">MDLKLGNETGITRNFWLFVLASTDLQLEITKSSSNTFYPCNVSNAISWGMATIEVEPLCNYTGVVKTLGKGTDSGSEAEVETTRVEDSDEDSSSDRSESTRIKVNSPGSSHCGSTIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8T0</accession>
    <name>A0A151N8T0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8T0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="210" mass="22374" checksum="C06E15803092BA38" modified="2016-06-08" version="1">MKLPAAPKGLPGPIPPLEQQALPLPHCSPSAWTASPSVDRAGAAPSPGRGAESPVSCPLDSPYLEWTAAGPFSFLHSDMANLSSFLGYFLTAGRLLSVLHQSLLPPDRADLPVNALQSSVLGSCGSRHAKLVLKRTALFPSGARALHFTVTKTLALCSSKLVFKGNLDRELCSANVESPGQRGAMAELRVGPFLTDERLSPWSRQQQKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9A9</accession>
    <name>A0A151N9A9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0014891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9A9"/>
    <dbReference type="STRING" id="8496.A0A151N9A9"/>
    <dbReference type="PhylomeDB" id="A0A151N9A9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="6">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO33085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="161" mass="18239" checksum="70317E46B3AC07B7" modified="2016-06-08" version="1">MDKSLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKVSSHLQVLARRKSREIQSKLKMLFSGHLGEVCKVPLEDGWRRPCQDATTGKGLARRLSVPDGGVIGEPQKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAC4</accession>
    <name>A0A151NAC4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAC4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="90" mass="9734" checksum="595886D849897CD8" modified="2016-06-08" version="1">MARSREAGRGEAAGSPQLAALAVAGPWQHVATGSDVPRNSAEEGRSSLPFTLRNPNLGVSVVDQQRNFFKADQLLISPAAKKYYRDSFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAV6</accession>
    <name>A0A151NAV6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TSC22 domain family protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TSC22D2</name>
        <name evidence="4" type="ORF">Y1Q_0024566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSC-22/Dip/Bun family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAV6"/>
    <dbReference type="STRING" id="8496.A0A151NAV6"/>
    <dbReference type="eggNOG" id="KOG4797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000002">
        <property type="entry name" value="TSC22 domain family, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047862">
        <property type="entry name" value="TSC22/BUN_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053049">
        <property type="entry name" value="TSC22_domain_protein_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46894">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46894:SF1">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01289">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO33962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="246" mass="26723" checksum="6988DD4CD79FB12B" modified="2016-06-08" version="1">MSKMPAKKKSCFQITSVTTAQVASSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPEDVCERSSSEETLNNVGQIDDTRRKSEPLPQPPLSLIAENKPHVKPPVPDTLTNPLHLPASTPMNSFASSVFGISIPVDGDEDSASGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNNDQLSQLSTQQANPSSTSQPQTVIAQPPQPTQPPQKPNVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBU0</accession>
    <name>A0A151NBU0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003562">
        <property type="protein sequence ID" value="KYO34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBU0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7444" checksum="3143EF87705336DB" modified="2016-06-08" version="1">MGTCTFEKQKLQRVCHLPLARCQSFPTWVLAASEFLACFEVGLQVPRRSAIIVPPAGWRIALKTAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NC92</accession>
    <name>A0A151NC92_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BSCL2</name>
        <name evidence="9" type="ORF">Y1Q_0022398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003464">
        <property type="protein sequence ID" value="KYO34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NC92"/>
    <dbReference type="STRING" id="8496.A0A151NC92"/>
    <dbReference type="eggNOG" id="KOG4200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="353" mass="38437" checksum="256F7533101316F5" modified="2016-06-08" version="1">MPPVSFASPAHFRFRSDCGAPGPELCSFPVANVSLVKRNRDRVLMPGQPYRISLELELPESPANRDLGMFMVAVTCYAKGGRTVAMSARTAMLHYRSTLLRVLHTLAFAVFFLTGFAEQKQTLEVELYSEYREDSYTPTVGAVIEIQSTRVQIYGAQLRVHAHFTGVRYLLYNFPVTSAVLGVASNFTFLSVIVLLSYLQWIWGSVWPREPLPGQVNLQEDSRRRVVTPMPAAGSEGTDLELKQPPEEGPEPEPWECPEGAAALQSKETLETLGPEGNRSQEPEPGEEPGFEAMDRSALEADVKLPPRGGSEPGAGASLRNWEGGKDPSQGPTSGSDPGSAPRGGMRSDTGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEI2</accession>
    <name>A0A151NEI2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">USP14</name>
        <name evidence="10" type="ORF">Y1Q_0007848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP14/UBP6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006277252.1">
        <property type="nucleotide sequence ID" value="XM_006277190.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEI2"/>
    <dbReference type="STRING" id="8496.A0A151NEI2"/>
    <dbReference type="GeneID" id="102558813"/>
    <dbReference type="KEGG" id="amj:102558813"/>
    <dbReference type="CTD" id="9097"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NEI2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000119">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000032">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="105"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="492" mass="55609" checksum="1F9F3F7A07098E53" modified="2016-06-08" version="1">MPLFSVNVKWGKEKFDGVELNTDEPPMVFKAQLFALTGVQPARQKVMLKGGTLKDEEWGNIKIKNGMTLLMMGSADALPEEPVARPVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPEVKEALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGDQGQYLQQDANECWVQMMRVLQQKLEGVEGDAVMETDSGAPAAASKKKSLIDQFFSVEFETAMKCTEAEEEDVTKGKENLLQLSCFINQEVKYLFTGLKLRLQEEITKLSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDVYELCTPELQEKMVPYRSKFKDLEDKKVNQQPKNSSKGDGVQKEVKYEPFSFPDDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRIEVIEDEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEY1</accession>
    <name>A0A151NEY1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FSD1-like protein isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FSD1L</name>
        <name evidence="5" type="ORF">Y1Q_0000996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEY1"/>
    <dbReference type="STRING" id="8496.A0A151NEY1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12901">
        <property type="entry name" value="SPRY_PRY_FSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035742">
        <property type="entry name" value="SPRY/PRY_FSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF8">
        <property type="entry name" value="FSD1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COS" evidence="4">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="261"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="486" mass="54651" checksum="C041BEBFEDA5F458" modified="2016-06-08" version="1">MDAQKEALQRIISTLANKNDEIQNFIDTLNHTLKGVQANSSNVIAELDEEFDGLYSILDEMKESMTNSIKQEQAHKTQELQNQLSQCSNALENSEELLEYAARSLDIKDPEEFSKAARQIKDRVTMASAFRISLKPKVSDNMTHLMVDFSQERQMLQALKFLPVPKAPEIDTAECLVADNTVTIAWRMPEEDKKIDHFALEYRKTNFDGLPRVKDERCWELIDYIKGIEYTLSGEYSDPITLETKALVFNLDGTSSHLNLKVEDSYVEWDPTGGKSQENKIKGKENKGSGQITVLKNNTRSGTPSPKRTSVTRSPLIRGSRDRFTGESYTVLGDTTIESGQHYWEVRAQKDCKSYSMGVAYKNMGKFDQLGKTNTSWCIHVNNWLQTTFSAKHNNKAKALDMPVPDRIGVYCDFDGGQLTFYNATSKQLLYTFKTKFTQPLLPGFMVWCGGLTVSTGLQVPSAVKTLQKSENGLSGSSSSLTNITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGD6</accession>
    <name>A0A151NGD6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0017352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003057">
        <property type="protein sequence ID" value="KYO35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGD6"/>
    <dbReference type="STRING" id="8496.A0A151NGD6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="155" mass="16417" checksum="6C4CC4EA04CADABD" modified="2016-06-08" version="1">MANEVTYSAVTIVARERERISPPASDPGNAVTYAEVYRHQKPEEGNPTDTPASGPSSRHSGWMYVSIVLGILSLILLTSITVLSYRSLSGSTYSSESPSKLSTNSVGDCTCPRENRTGKSIEQEEGCGTGRVANPPGLTGISIDLLVTIESNPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHJ3</accession>
    <name>A0A151NHJ3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHJ3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="10865" checksum="90D5586121111F78" modified="2016-06-08" version="1">MGEAFRKILSEDQRRAFAERALLGIHHVTLHVSQAGVVLLYAILGQAGHLMGAEEKEIPIRVLRKLLILKCFHQLPKELQRHSHLESALRNPSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHP8</accession>
    <name>A0A151NHP8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase II subunit F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RPB6 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">POLR2F</name>
        <name evidence="11" type="ORF">Y1Q_0024101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPABC2 is part of the clamp element and together with parts of POLR2A/RPB1 and POLR2B/RPB2 forms a pocket to which the POLR2D/RPB4-POLR2G/RPB7 subcomplex binds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259018.1">
        <property type="nucleotide sequence ID" value="XM_006258956.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHP8"/>
    <dbReference type="STRING" id="8496.A0A151NHP8"/>
    <dbReference type="GeneID" id="102572142"/>
    <dbReference type="KEGG" id="amj:102572142"/>
    <dbReference type="CTD" id="5435"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NHP8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002207">
        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="127" mass="14467" checksum="54A46A60F68808EE" modified="2016-06-08" version="1">MSDNEDNFDGDDFDDGEEDEGLDDLENAEEEGQENVEILPSGERQQANQKRITTPYMTKYERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGVDELIITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIA7</accession>
    <name>A0A151NIA7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIA7"/>
    <dbReference type="STRING" id="8496.A0A151NIA7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO36537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15253" checksum="A14DA564C137EB79" modified="2016-06-08" version="1">MRKLGIIEDSQSPWRSPMMVIPKPNGSIRLCIDYRKVNEIATFDAFPMPQVDDMLERVGQAWLRKSKEEATMCLTGGKGVEQWPKGSMLATVAAFYQELYAEKPVDLEVMQLCLQSLTWIIRENEQWQLEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKM3</accession>
    <name>A0A151NKM3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002770">
        <property type="protein sequence ID" value="KYO37310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKM3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039689">
        <property type="entry name" value="CD72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15028:SF6">
        <property type="entry name" value="B-CELL DIFFERENTIATION ANTIGEN CD72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15028">
        <property type="entry name" value="CD72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="89" mass="9655" checksum="989328407997A6A0" modified="2016-06-08" version="1">MGESVTYAELQFSKAPPGRSVSPQAQGKVLQALGKADDAHETFQLCPVERWWSTHPLPLVLLAACLALLATTITLGAFYWQVGTELEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMY0</accession>
    <name>A0A151NMY0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-galactosidase</fullName>
            <ecNumber evidence="15">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GLA</name>
        <name evidence="18" type="ORF">Y1Q_0007263</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer(d18:1(4E)) + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:21112"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17950"/>
            <dbReference type="ChEBI" id="CHEBI:18313"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a globoside Gb3Cer + H2O = a beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1)-ceramide + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:48020"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:79208"/>
            <dbReference type="ChEBI" id="CHEBI:88154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:48021"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMY0"/>
    <dbReference type="SMR" id="A0A151NMY0"/>
    <dbReference type="STRING" id="8496.A0A151NMY0"/>
    <dbReference type="GeneID" id="102565208"/>
    <dbReference type="KEGG" id="amj:102565208"/>
    <dbReference type="CTD" id="2717"/>
    <dbReference type="eggNOG" id="KOG2366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046479">
        <property type="term" value="P:glycosphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000070">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000017">
        <property type="entry name" value="Alpha-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035373">
        <property type="entry name" value="Melibiase/NAGA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF14">
        <property type="entry name" value="ALPHA-GALACTOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17450">
        <property type="entry name" value="Melibiase_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586202" description="Alpha-galactosidase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase A C-terminal" evidence="17">
        <location>
            <begin position="316"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO38148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="431" mass="47823" checksum="87730480E7BE3942" modified="2016-06-08" version="1">MAAALVWAMAVLALALAEGAGALDNGLAQTPPMGWLHWERFLCTTDCASAPHACVSEQLFMQMADLLAAEGWRDAGYEYVCIDDCWMAPSRDGGDRLQPDPQRFPHGIHQLADYVHSKGLKLGIYGDVGNKTCAGYPGSYGHYDLDAQTFADWGVDLLKFDGCYHGTLDLLAEGYKNMSLALNKTGRSIVYSCEWPFYMLPVQKPNYTEVKQYCNHWRNFADVFDAWISIKSILDWTASHQDIIVDVAGPGGWNDPDMLVIGNFGLSWDQQVTQMALWAIMAAPLFMSNDLRQISPQAKRLLQNKEVIAINQDPLGKQGYRITKDNNFELWERPLTGRAYAVAVVNRQEIGGPQLFTFATSFLGNGLACNPACSIQQILPTSEDYGLHNWVSFLKVKVNPTGTVLLKAAVIEEFPEEKLAPNSKKPSLDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNP1</accession>
    <name>A0A151NNP1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Putative P2Y purinoceptor 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">P2RY10</name>
        <name evidence="15" type="ORF">Y1Q_0015653</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Putative receptor for purines coupled to G-proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNP1"/>
    <dbReference type="STRING" id="8496.A0A151NNP1"/>
    <dbReference type="eggNOG" id="ENOG502QTX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000146">
        <property type="entry name" value="putative P2Y purinoceptor 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF6">
        <property type="entry name" value="PURINERGIC RECEPTOR P2Y, G-PROTEIN COUPLED 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="104"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO38408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="393" mass="44720" checksum="C26F3A8E88349871" modified="2016-06-08" version="1">MVLVGQLIIIGKMCRNGPKWNLNKGFCGRGRHCIVLPLLNTPVTASEIPVIQEILHPSHPVPNDRTDTFKMASNGSGCAEPNITFKHHLYAVTYTIVFIPGLLANSTALWVLCRFISKKNKAVIFMINLAVADLAHVLSLPLRIYYYINNVWPFGHRLCLLCFYLKYLNMYASICFLTCISIQRYFFLYNPFKAKDWKRRYDAAISVAIWMFVGAACSPFPIMRYQGITNSANACFADLAVKKISSKVVPVVMTIVAELLGFVGPLIVIVYCTWKTKESLQTFQMPLQSSEKRKALRMISTCAIVFFICFTPYHINFFFYMMVKEDIITDCSIRISTLYTQPFCLSLASLDCCLDPILYFFTTSEFQDQISRHSSIVIRSRLMSKESGSSIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNZ0</accession>
    <name>A0A151NNZ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002441">
        <property type="protein sequence ID" value="KYO38566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNZ0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7924" checksum="FDA6F633F09BDE51" modified="2016-06-08" version="1">MMPLIQLSLEAPANTSEAAKLGTTASIWLKLEPDKWRIGAQQCDRRKQLWHIKKQTSIRSLRKLVLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRU0</accession>
    <name>A0A151NRU0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002337">
        <property type="protein sequence ID" value="KYO39185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRU0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8454" checksum="8F52D05984F00F1E" modified="2016-06-08" version="1">MGEKPLLTERGKMENDDKIHDDGEQCSEESSDMENMEDMDKRVAMAIMKLASPSCLRYIMNQFSVAVFMVGLATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSZ8</accession>
    <name>A0A151NSZ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HIST1H4D</name>
        <name evidence="21" type="ORF">Y1Q_0006755</name>
        <name evidence="22" type="ORF">Y1Q_0006758</name>
        <name evidence="17" type="ORF">Y1Q_0020086</name>
        <name evidence="18" type="ORF">Y1Q_0020089</name>
        <name evidence="19" type="ORF">Y1Q_0020091</name>
        <name evidence="20" type="ORF">Y1Q_0020093</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Alligator mississippiensis genome assembly.</title>
            <authorList>
                <person name="Rice E.S."/>
                <person name="O'Connell B.L."/>
                <person name="Putnam N."/>
                <person name="Sugnet C."/>
                <person name="Stites J."/>
                <person name="Kern C."/>
                <person name="Gresham C."/>
                <person name="Mccarthy F."/>
                <person name="Schmidt C.J."/>
                <person name="Green R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSZ8"/>
    <dbReference type="SMR" id="A0A151NSZ8"/>
    <dbReference type="STRING" id="8496.A0A151NSZ8"/>
    <dbReference type="KEGG" id="amj:102560480"/>
    <dbReference type="KEGG" id="amj:102562569"/>
    <dbReference type="KEGG" id="amj:102562659"/>
    <dbReference type="KEGG" id="amj:102563125"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9025240at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0164">Citrullination</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="16">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO17483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO17486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO17488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO17490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO39891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO39894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11367" checksum="A9E5DFD3F8B97598" modified="2016-06-08" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NT81</accession>
    <name>A0A151NT81_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tigger transposable element-derived protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0017050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002096">
        <property type="protein sequence ID" value="KYO40077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NT81"/>
    <dbReference type="eggNOG" id="KOG3105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF36">
        <property type="entry name" value="TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="180"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO40077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="621" mass="67749" checksum="338ED160303F718A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUA9</accession>
    <name>A0A151NUA9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ephrin RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0013063</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001925">
        <property type="protein sequence ID" value="KYO40447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NUA9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000006">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000012">
        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586381" description="Ephrin RBD domain-containing protein" evidence="16">
        <location>
            <begin position="23"/>
            <end position="2652"/>
        </location>
    </feature>
    <feature type="domain" description="Ephrin RBD" evidence="17">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="343"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO40447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2652" mass="298759" checksum="3ED5CBABED159307" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVS9</accession>
    <name>A0A151NVS9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Actin-binding LIM protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0009565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="8496.A0A151NVS9"/>
    <dbReference type="eggNOG" id="KOG1044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09327">
        <property type="entry name" value="LIM1_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09328">
        <property type="entry name" value="LIM2_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09329">
        <property type="entry name" value="LIM3_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09330">
        <property type="entry name" value="LIM4_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000003">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000004">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000007">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000024">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.950.10:FF:000001">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF18">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="251"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="HP" evidence="11">
        <location>
            <begin position="756"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="650"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO40535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="92818" checksum="A326C95A491057FF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXK5</accession>
    <name>A0A151NXK5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-like protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ACTL9</name>
        <name evidence="8" type="ORF">Y1Q_0011873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXK5"/>
    <dbReference type="STRING" id="8496.A0A151NXK5"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO41155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="371" mass="41730" checksum="75262C379597B94C" modified="2016-06-08" version="1">MQRTGAVVIDTGTGCCKAGFAGQQNPKSVLGSWVGRPTERSFKLRGARPDTFVGERARTQPDVEVIEPVRNGIIIDWEAAEVLWRHMFYHDLQVRPEDHALLMSDPPLSPTTNREKMVEVVFESLNSPGMYIAYHSVLSVYAHGKISGLVVDSGYAVTHTVPVHQGYNLPHAIERMDIAGSHMTSFLMKLLNDSGHVFTERMTHIVEDIKHKCCYVAANFERECHLPRKDYVVDFQLPDGHVISLGKERFQCPEMLFTPPKLPGISFVGVHNMAQRSLSKVPEEARGDMYQNIFLCGGSSLFNGLEKRFTSELLRHLPSSAKVRVSAVPLRKFSVWTGGSILASLKNFQACWIQKEQYNDIGPYVVHRKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYF3</accession>
    <name>A0A151NYF3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cilia- and flagella-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0004480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFAP45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001603">
        <property type="protein sequence ID" value="KYO41783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYF3"/>
    <dbReference type="KEGG" id="amj:102561086"/>
    <dbReference type="OrthoDB" id="1902038at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033253">
        <property type="entry name" value="CFAP45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504">
        <property type="entry name" value="NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO41783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="122" mass="14600" checksum="3669D75C6F6F07E6" modified="2016-06-08" version="1">MACKEHEQMIQTKWDHSYYDQVLREQREQAQKEQKQQEERAAKQMAHGKAVRSQMTERQEPLVQERAVCFEDGKRLQKEMQKHADRIAQLKRMRMEELRATGLPERYCVGVEYKALKPGPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZ92</accession>
    <name>A0A151NZ92_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001512">
        <property type="protein sequence ID" value="KYO41909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZ92"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO41909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7154" checksum="F8C30BAB04AD2343" modified="2016-06-08" version="1">MSVGRALVTYPTSESTSVCTEVNAEGESQEHLSGCCYRLPAGAESSGMDTQGSFELSCTGAVQQEGLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZF7</accession>
    <name>A0A151NZF7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Androgen-induced 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0002672</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZF7"/>
    <dbReference type="eggNOG" id="KOG3989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF22">
        <property type="entry name" value="ANDROGEN DEPENDENT TFPI REGULATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO42020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="178" mass="20605" checksum="05A36052CE3B093C" modified="2016-06-08" version="1">MAGRERLRGERPVTVLHLCCFLWALFSLCQNVGLPNSPRRDSETTYGGRWKYLTFLNQILQTVLFGLCTLMDAVHMFLPTRQRSISRLLPLKDFIFSVLVFPVGLFVAITFWTLYAYDRELVYPKELDEVNPSWLNHTMHTTILPLLLIELVSCPHKYPHKLKGIIGLSIFGSSYLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZS6</accession>
    <name>A0A151NZS6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0022518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001509">
        <property type="protein sequence ID" value="KYO41925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZS6"/>
    <dbReference type="STRING" id="8496.A0A151NZS6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SCAN box" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB-related" evidence="7">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="6">
        <location>
            <begin position="204"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28189" checksum="FE7684CE11FB50C3" modified="2016-06-08" version="1">MLELVVLEQFLAILPRETRSWEWGRGVETCAQAVALAEGAQPGQVTVSMKIEEVSSDKMQPTGSLQEPGDCWLEQPKAHPADMSLEEAGQRETPRPQDKTPHVPKKEHPPDQKSADAPKAEETWDWSANKRSSDWCPEGSLSLGAGTLSRADEQPSEEGPVILELWWTSPGRMGEMGSLMPEPGQLEKGQSMPPKQGESLELWDAFEDVALHFTRKEWELLEDEDKVLYRDQMLRNYQALISLGKALVLGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0L7</accession>
    <name>A0A151P0L7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001362">
        <property type="protein sequence ID" value="KYO42682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0L7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="11358" checksum="5CE014E2CECD3452" modified="2016-06-08" version="1">MHTAFEGLAGPSSETERFFSKESSGDAVPPPVYGRVSGGEGGLWWGCSQETVPVTFRFLAGPEGGSVPCRWVLGSKKPRWHAKPLVRCHKQSRALLLEFVAMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P152</accession>
    <name>A0A151P152_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger protein 883-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0023050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001354">
        <property type="protein sequence ID" value="KYO42743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P152"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000116">
        <property type="entry name" value="Zinc finger protein 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001119">
        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB-related" evidence="12">
        <location>
            <begin position="123"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="11">
        <location>
            <begin position="126"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO42743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="69635" checksum="0FE940B4744A94C1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2R3</accession>
    <name>A0A151P2R3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 9 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC9-1</name>
        <name evidence="4" type="ORF">Y1Q_0017841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001206">
        <property type="protein sequence ID" value="KYO43366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2R3"/>
    <dbReference type="STRING" id="8496.A0A151P2R3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029336">
        <property type="entry name" value="DUF4594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15635">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15635:SF11">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15266">
        <property type="entry name" value="DUF4594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO43366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="459" mass="49797" checksum="DEEA74298BB4DC23" modified="2016-06-08" version="1">MNEEMEKIAEYERNQRDGLRERNPVRNFLDDPRRSGPFQEVDRKEGSRRHGRNWGGSDFDKVKTGMEREKEWRTPGQRPGPRGRGALDMTLSMTGRERAEYMRWKQEREQIDQERLARHRKPTGQWRREWDAEKTDTMFKEGSAPAPGPDGGSRQDESRRPPKPPTFGEFLSEHRSERRRKGRGRGGGTSTKPYSMHDNRWEEKETLPPAEESDCSPGPRGEAVSPAAQTPPEPPAPPVPEEDEDQWEDVSGEEEEEDEGDEEEDEDGSGSSDEDKAPPPGSPKAQRAPKAGRGAAPKLAMPPAGVPAGEGKPLSPFSPVEGYRPVSDWGEEMELNSPRGNLGHSPLQGLGAGPQAQGVSVAGAATDLSPPAPSECPGGQGAPEAARQEAAEPVGDAEAPAAPGMTEAPESVTPTATTELEAPGVAVTPPAAEPAPGTVEITDFARVRFRKSSPSPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P348</accession>
    <name>A0A151P348_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GALNT14</name>
        <name evidence="21" type="ORF">Y1Q_0013540</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Golgi apparatus membrane</location>
            <topology evidence="2 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019338640.1">
        <property type="nucleotide sequence ID" value="XM_019483095.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P348"/>
    <dbReference type="STRING" id="8496.A0A151P348"/>
    <dbReference type="GeneID" id="106736675"/>
    <dbReference type="KEGG" id="amj:106736675"/>
    <dbReference type="CTD" id="79623"/>
    <dbReference type="eggNOG" id="KOG3738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429263at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P348"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23478">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000063">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000020">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF8">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 19" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="20">
        <location>
            <begin position="419"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO43491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="551" mass="63620" checksum="A620CFFB13BB67D6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3I8</accession>
    <name>A0A151P3I8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calpain-2 catalytic subunit</fullName>
            <ecNumber evidence="6">3.4.22.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Calcium-activated neutral proteinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Calpain M-type</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Calpain-2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Millimolar-calpain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">CAPN3</name>
        <name evidence="26" type="ORF">Y1Q_0013572</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Broad endopeptidase specificity.</text>
            <dbReference type="EC" id="3.4.22.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.53" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3I8"/>
    <dbReference type="STRING" id="8496.A0A151P3I8"/>
    <dbReference type="GeneID" id="102560432"/>
    <dbReference type="KEGG" id="amj:102560432"/>
    <dbReference type="CTD" id="824"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P3I8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000099">
        <property type="entry name" value="calpain-2 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF268">
        <property type="entry name" value="CALPAIN-2 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 23" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="14 23" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="24">
        <location>
            <begin position="45"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="25">
        <location>
            <begin position="602"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" evidence="22 23">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="22 23">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="22 23">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO43540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="700" mass="79277" checksum="636CE5F184A3467E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4U0</accession>
    <name>A0A151P4U0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0016950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000940">
        <property type="protein sequence ID" value="KYO44066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4U0"/>
    <dbReference type="STRING" id="8496.A0A151P4U0"/>
    <dbReference type="KEGG" id="amj:109282044"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000025">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041306">
        <property type="entry name" value="C5HCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17982">
        <property type="entry name" value="C5HCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="12">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="100"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="590"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO44066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="621" mass="66192" checksum="C2482C984B23DBD4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5I1</accession>
    <name>A0A151P5I1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Src kinase-associated phosphoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SKAP1</name>
        <name evidence="17" type="ORF">Y1Q_0012097</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5I1"/>
    <dbReference type="STRING" id="8496.A0A151P5I1"/>
    <dbReference type="eggNOG" id="ENOG502QSSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13380">
        <property type="entry name" value="PH_Skap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037781">
        <property type="entry name" value="SKAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129:SF1">
        <property type="entry name" value="SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129">
        <property type="entry name" value="SRC-ASSOCIATED ADAPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="115"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO44327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="349" mass="40063" checksum="0A2FAE939F5D63FE" modified="2016-06-08" version="1">MQAPGSFIPEEIQGLLEDAEVYLVDGLQNENLSARAREEREMILFNFQHIKARYHLEFLPRGGDAVDAGYAQDSSDDNQSWTCAPSMVSDASFPSDYQDDGSEDNIQKPTQEVESILKQGYLEKRSRDHSFFGSEWQKRWCVLNRKIFYYYANEKSKQPKGTFSVEHYSARMAPHLRKDSRKESCFELTCPGKRSYEFTASSSAEARDWVDQIQFLLKDMSSFTIPYDEEDEEEETYDDIDSFDTPNTAVHNASLNMEEAETAAASGEEEDDIYEVLPDEDLDMPFPEDRRDAGSSIKTGGSMKDYANYYQSMWDCISDYPDELSFQRGDIIYIVSKEYNIGELIKGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5V2</accession>
    <name>A0A151P5V2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shadow of prion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0016737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000764">
        <property type="protein sequence ID" value="KYO44424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5V2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO44424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19108" checksum="ADAA5970D0048C43" modified="2016-06-08" version="1">MQHAAHWKSSLDKGRKRETLPKPKQHKSVRMRHLDAWIWIAVLLIALFSDAAFCRKGGGGRSSGRGSVKSGGLRGGFQSLAKSSSGSSLSKESSPKRGTKMAGVAAAGAAVGYGMGLLGRSRAGRGTSGGKQMTQSGFYYPNWSEPFAKGELYNQAPKGAQAFTTLILSLILCCLNIFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6U5</accession>
    <name>A0A151P6U5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6U5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="11234" checksum="AAEF13FA094FA0D7" modified="2016-06-08" version="1">MSEEVLTKAKVLQKNLNRIEAQKKISTCPSIPLHPIKMKDDDLKCTSVTVMSIQALVTSWFWTLLEQPAMNCIKLVWHQMKNNIRTIVNSGIEPRKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6Z7</accession>
    <name>A0A151P6Z7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0023108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000760">
        <property type="protein sequence ID" value="KYO44505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6Z7"/>
    <dbReference type="STRING" id="8496.A0A151P6Z7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF206">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="70"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO44505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="180" mass="19732" checksum="274904FEE6245DF3" modified="2016-06-08" version="1">MAIVKLASPTSLCCIANQFGMAACMVGQVTHEVCQLLRDIASNKVISLVNPQQVMDGFNEKEFLNCLGALDSTHIPVLCPAGSGKLYTKRKGYASMILQAMVDHCGWFMNIFTGWADRTHDVRIFRNSPLADLGEKGHYTPGMEERVLCGVTIPPIVLADAAYPLKPWLMKPYGGNITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P723</accession>
    <name>A0A151P723_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000640">
        <property type="protein sequence ID" value="KYO44862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P723"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="9877" checksum="DF31F867DCE3E2A7" modified="2016-06-08" version="1">MIYSLEEESQQESLKIQTAAAPPILNLRDDAEKRLLADQREKRGLTHSLLFSLLSGRRRKGKNGDDSYYRTTEQAGGDHGSRENGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P734</accession>
    <name>A0A151P734_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GALNT8</name>
        <name evidence="20" type="ORF">Y1Q_0016827</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Golgi apparatus membrane</location>
            <topology evidence="2 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P734"/>
    <dbReference type="STRING" id="8496.A0A151P734"/>
    <dbReference type="eggNOG" id="KOG3736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23472">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000017">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000192">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF50">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 18" id="KW-0430">Lectin</keyword>
    <keyword evidence="17 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="490"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO44709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="655" mass="75238" checksum="850EEAB77B706E68" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P878</accession>
    <name>A0A151P878_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Potassium channel subfamily K member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KCNK9</name>
        <name evidence="18" type="ORF">Y1Q_0014690</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P878"/>
    <dbReference type="STRING" id="8496.A0A151P878"/>
    <dbReference type="GeneID" id="102570221"/>
    <dbReference type="KEGG" id="amj:102570221"/>
    <dbReference type="CTD" id="51305"/>
    <dbReference type="eggNOG" id="KOG4404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P878"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000057">
        <property type="entry name" value="Potassium channel subfamily K member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005407">
        <property type="entry name" value="KCNK9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF75">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01585">
        <property type="entry name" value="TASK3CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 14 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5 14" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="168"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO45242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="374" mass="42581" checksum="52235F1FF8579E5E" modified="2016-06-08" version="1">MKRQNVRTLSLIICTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRLKGKYNITSEDYRQLELVIMQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVKYLLKRIKKCCGMRSTEVSMENMVTVGFFSCMGTLCIGAAAFSQYEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMIIHIQEDSQHGRPRYKAEVTDLQSVCSCMCYRSHEYTSRVVSHQNSFSSKLNPQYFHSISYKIEEISPSTLKNSLFPSPVSSISPGLHSFTDNHRLMKRRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8J1</accession>
    <name>A0A151P8J1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor GTPase-activating protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ARFGAP3</name>
        <name evidence="19" type="ORF">Y1Q_0023061</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000602">
        <property type="protein sequence ID" value="KYO45343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8J1"/>
    <dbReference type="STRING" id="8496.A0A151P8J1"/>
    <dbReference type="KEGG" id="amj:102569454"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P8J1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09028">
        <property type="entry name" value="ArfGap_ArfGap3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="18">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO45343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="519" mass="57525" checksum="1F336D259A4B05D7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8T6</accession>
    <name>A0A151P8T6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Poly(A) polymerase</fullName>
            <ecNumber evidence="14">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PAPOLA</name>
        <name evidence="21" type="ORF">Y1Q_0015109</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="14"/>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8T6"/>
    <dbReference type="STRING" id="8496.A0A151P8T6"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF9">
        <property type="entry name" value="POLY(A) POLYMERASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="20">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="19">
        <location>
            <begin position="219"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="18">
        <location>
            <begin position="366"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="522"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO45444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="775" mass="86848" checksum="F01DC7F5DFD4A365" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAH0</accession>
    <name>A0A151PAH0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Exocyst complex component 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Exocyst complex component Sec3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CEP135</name>
        <name evidence="23" type="ORF">Y1Q_0021611</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EEF1A1. Interacts with SLC6A9; interaction increases the transporter capacity of SLC6A9 probably by promoting its insertion into the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Midbody</location>
            <location evidence="4">Midbody ring</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the CEP135/TSGA10 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PAH0"/>
    <dbReference type="eggNOG" id="ENOG502QT27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22292">
        <property type="entry name" value="cc_Cep135_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14683">
        <property type="entry name" value="PH-EXOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000001">
        <property type="entry name" value="exocyst complex component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN 135KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="22">
        <location>
            <begin position="39"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="450"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1979"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="946"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1077"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1148"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1784"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1868"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1985"/>
            <end position="2005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00079611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO46023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2028" mass="234278" checksum="4F0F72F2E9043D71" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAI8</accession>
    <name>A0A151PAI8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0021625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAI8"/>
    <dbReference type="STRING" id="8496.A0A151PAI8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="2">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO46043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="225" mass="26097" checksum="566F1FB2F9DAC63F" modified="2016-06-08" version="1">MTKEDDPEAYIEAFERHALMTSLPQEHWASQLGALVVGVAQAAYRAIPREEARDYEWVKQAILYQLELSPDYYRHLFRAKKRPDERRPRVLLQLLRDLLDKWVSPVGSDHQDLADQVILEQFQIDLDERTQRWVRQHTPRNCEEALKLAEAYVAAEASYLKEQRNQKPTSLLLREAERRPAPIRGTGATAATQTKQQNRRRTRRTTALVYPGKAPVIPMTFLGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PD53</accession>
    <name>A0A151PD53_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Keratin, type I cytoskeletal 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0018450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PD53"/>
    <dbReference type="STRING" id="8496.A0A151PD53"/>
    <dbReference type="eggNOG" id="ENOG502QSI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF379">
        <property type="entry name" value="IF ROD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="107"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="350" mass="40353" checksum="3099B3F6A183068B" modified="2016-06-08" version="1">MQNLNDRLATYLDKVRRLEEENADLEERIREWYRKQGPSISKDYSPYYQTIEQLQNQIISATVDNNKLILDIDNSKMIADDFRMKYENELAIRQGVEADINGLRNFLDELVRVRSTLELEVETLKDELLTLKKNHEEEMRLLQSQTGGDVNVEVNAAPGQDLTKILNDMRQEYEEIIAKNRREVEQWYEVKMEEVNQQVTSSGQEVQTSSHQLTELRRDFQSLEIELQTQLSMKASLENNLAETEARYGAQLQQIQAMINCVEEELAQLRCEMESQNQEYKMLLGIKTRLEQEIAQYHGLLQEGQQDITSSQGGIQGGGRSSQSYSSHSYSSTSHSQSHGGEMTGQTRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PER7</accession>
    <name>A0A151PER7_ALLMI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PER7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="8978" checksum="EDCFBDEE0849D2CB" modified="2016-06-08" version="1">MNNGGDAANVGQLVILPYSITVTTLWTCPLQPKNILAKCVFEAISQACCIQRVLQLFLPQKSAPLLGALFSPATVGHFQCSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PH80</accession>
    <name>A0A151PH80_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000230">
        <property type="protein sequence ID" value="KYO48254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PH80"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="8323" checksum="8BEFF7588D616331" modified="2016-06-08" version="1">MQLIPIRQDDRQKAEPESTDEPENEKWGKETFSRPFIKKERKKFYLHRIVTPQSPLKPNLLFKGLGNTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHC2</accession>
    <name>A0A151PHC2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoinositide 3-kinase adapter protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">B-cell adapter for phosphoinositide 3-kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">B-cell phosphoinositide 3-kinase adapter protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PIK3AP1-1</name>
        <name evidence="14" type="ORF">Y1Q_0001972</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHC2"/>
    <dbReference type="STRING" id="8496.A0A151PHC2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036312">
        <property type="term" value="F:phosphatidylinositol 3-kinase regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000010">
        <property type="entry name" value="phosphoinositide 3-kinase adapter protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052446">
        <property type="entry name" value="B-cell_PI3K-Signaling_Adptrs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017893">
        <property type="entry name" value="DBB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041340">
        <property type="entry name" value="PIK3AP1_TIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267">
        <property type="entry name" value="BANK1/PIK3AP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267:SF12">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE ADAPTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14545">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18567">
        <property type="entry name" value="TIR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01282">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51376">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="74"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DBB" evidence="13">
        <location>
            <begin position="251"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="767"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="781"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO48175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="867" mass="97617" checksum="B2B7F8198B8723B5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZP9</accession>
    <name>A0A151LZP9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Integrin alpha-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ITGA4</name>
        <name evidence="18" type="ORF">Y1Q_0011444</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZP9"/>
    <dbReference type="STRING" id="8496.A0A151LZP9"/>
    <dbReference type="KEGG" id="amj:102564142"/>
    <dbReference type="eggNOG" id="KOG3637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF78">
        <property type="entry name" value="INTEGRIN ALPHA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13 18" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039762220" evidence="13">
        <location>
            <begin position="28"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="975"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="181"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="350"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="411"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="15">
        <location>
            <begin position="458"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="619"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="17">
        <location>
            <begin position="774"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1012"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1012"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO17755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1036" mass="114408" checksum="130552B1B287437F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0E6</accession>
    <name>A0A151M0E6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Plakophilin-4 isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PKP4</name>
        <name evidence="11" type="ORF">Y1Q_0011590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0E6"/>
    <dbReference type="STRING" id="8496.A0A151M0E6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000008">
        <property type="entry name" value="plakophilin-4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF8">
        <property type="entry name" value="PLAKOPHILIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="563"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="607"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="865"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="766"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO17973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1185" mass="131634" checksum="3DA43339466117D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0Q3</accession>
    <name>A0A151M0Q3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RAB3GAP1</name>
        <name evidence="13" type="ORF">Y1Q_0011684</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0Q3"/>
    <dbReference type="STRING" id="8496.A0A151M0Q3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045698">
        <property type="entry name" value="Rab3GAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19533">
        <property type="entry name" value="Rab3-GAP_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="11">
        <location>
            <begin position="622"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP catalytic subunit C-terminal" evidence="12">
        <location>
            <begin position="787"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO18095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113005" checksum="A26E5DE9DFA704EB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1C7</accession>
    <name>A0A151M1C7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho-related GTP-binding protein RhoG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RHOG</name>
        <name evidence="6" type="ORF">Y1Q_0012777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in immunological synaptic F-actin density and architecture organization. Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity. Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells. Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D. Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with ARHGEF26. Interacts with ARHGEF16. Interacts with UNC13D; the interaction increases RhoG affinity to the membrane lipids, targets UNC13D to membrane lipids and facilitates cytotoxic granule (CG) docking to the plasma membrane.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006834">
        <property type="protein sequence ID" value="KYO18292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014465022.1">
        <property type="nucleotide sequence ID" value="XM_014609536.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1C7"/>
    <dbReference type="STRING" id="8496.A0A151M1C7"/>
    <dbReference type="GeneID" id="106737282"/>
    <dbReference type="KEGG" id="amj:106737282"/>
    <dbReference type="CTD" id="391"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M1C7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO18292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="191" mass="21374" checksum="D6D1C9DF27FE6CC3" modified="2016-06-08" version="1">MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQNTVDGRTINLNLWDTAGQEEYDRLRTLSYPQTNVFIICFSIASPPSYENVKHKWYPEVCHHCPNVPILLVGTKKDLRNNPETMKKLKEQNQAPVTTQQGITLSKQIHAVKYLECSALNQEGIKDVFTEAVRAVLNPAPAKPKKSCVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1H1</accession>
    <name>A0A151M1H1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nucleoside diphosphate phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ENTPD6</name>
        <name evidence="8" type="ORF">Y1Q_0008490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.6" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1H1"/>
    <dbReference type="STRING" id="8496.A0A151M1H1"/>
    <dbReference type="eggNOG" id="KOG1385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000052">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF99">
        <property type="entry name" value="ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="186"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO18364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="413" mass="45700" checksum="0F625973E4021D55" modified="2016-06-08" version="1">MDSKPMSGVTDGTTENKGDKLDHQTSAADLSVFYGIMFDAGSTGTRIHIFKFTQKSKETPKLTHETFKALKPGLSAYADDVDKSAQGIQELLDVAKKEVPVELWKFTPLVLKATAGLRLLPGEKAQKLLDKVKEIFQASPFFVRDDCVSIMNGTDEGVSAWITINFLTGNLNVPRKRSVGMLDLGGGSTQITFLPSSKTTLQTSPAGHLAAFQMFNNTYKLYSYSYLGLGLMSARLAILGGVEGKPLKEGEELISSCLSPGFKTEWEHAEIVYRVKGQKAGEPLYESCSNKVAKMLYKKVYKAEEVKDLDFYAFSYYYDCAAEVSLIDKEKGGSLTVSDFETAAKYVCKTMEVSPGDNPFLCMDLTYISVLLQELGFPKSQVFKLARKIDDIETSWALGATFHYIDSLNRLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1K6</accession>
    <name>A0A151M1K6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0008512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1K6"/>
    <dbReference type="STRING" id="8496.A0A151M1K6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12646">
        <property type="entry name" value="RRM_SRSF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000078">
        <property type="entry name" value="serine/arginine-rich splicing factor 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034651">
        <property type="entry name" value="SRSF7_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO18393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="134" mass="15088" checksum="7670C37D4EB7C901" modified="2016-06-08" version="1">MSRYGRYETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVLGLDGKIICGSRIPFKIQRKKVFSLTQPKSWQEIQTCPNFGGLTFSGKIKVQITVSKEKPFTIRKSIKECKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1W3</accession>
    <name>A0A151M1W3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox protein OTX2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OTX2</name>
        <name evidence="12" type="ORF">Y1Q_0014776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1W3"/>
    <dbReference type="STRING" id="8496.A0A151M1W3"/>
    <dbReference type="eggNOG" id="KOG2251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000142">
        <property type="entry name" value="homeobox protein OTX2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003022">
        <property type="entry name" value="Otx2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003025">
        <property type="entry name" value="Otx_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013851">
        <property type="entry name" value="Otx_TF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN OTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03529">
        <property type="entry name" value="TF_Otx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01257">
        <property type="entry name" value="OTX2HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01255">
        <property type="entry name" value="OTXHOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584674" evidence="10">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO18503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="373" mass="40764" checksum="AA8512131B148936" modified="2016-06-08" version="1">MVALVLLALLARSRHVRLCELLIWNLPRIIWAGFFCPFPTPRLEASRAPVAGRTQPLPPSTQGCRDPSPLAPIAASSLPRSNFSMMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKSSPAREVSSESGTSGQFSPPSSTSVPAISSSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3S3</accession>
    <name>A0A151M3S3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0006518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006692">
        <property type="protein sequence ID" value="KYO19162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3S3"/>
    <dbReference type="STRING" id="8496.A0A151M3S3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO19162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="15478" checksum="FB6DA39AF47E1B26" modified="2016-06-08" version="1">MAVGAVLTQEEGDNERPVAYTSRKLLPVEKRCKGEDQTGDLENQARGLTGPTVRTAAVAARAATVKKPAKKPVEKPAKEPAEELVEKPAKKPAEEPVEKPAKKPAEEPAEELVGNPAKKPEEETAKELAEKLIAKPAEEPAGKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5Z6</accession>
    <name>A0A151M5Z6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006485">
        <property type="protein sequence ID" value="KYO19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5Z6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="10939" checksum="9845B171CE1F134C" modified="2016-06-08" version="1">MPENSRDISAKPRKKFLSYRLPRIQSLHLFNLVCKMMGPVMESLYQPVETGRMMQTMAQKTITPKGQVDYCITLLMEIIPFCHHAALSSAKARGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6J1</accession>
    <name>A0A151M6J1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6J1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7649" checksum="2B6E109212A39B5B" modified="2016-06-08" version="1">MEQLLRAVAGGPSGLDLYGQKLNVLAYADNLILLAPDTTQLQQMLYVTSKAARWMGLCSNVTKPIGPQSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7G2</accession>
    <name>A0A151M7G2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicastrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NCSTN</name>
        <name evidence="17" type="ORF">Y1Q_0005891</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006405">
        <property type="protein sequence ID" value="KYO20437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7G2"/>
    <dbReference type="STRING" id="8496.A0A151M7G2"/>
    <dbReference type="GeneID" id="102561938"/>
    <dbReference type="KEGG" id="amj:102561938"/>
    <dbReference type="CTD" id="23385"/>
    <dbReference type="eggNOG" id="KOG2657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M7G2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007220">
        <property type="term" value="P:Notch receptor processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03881">
        <property type="entry name" value="M28_Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000030">
        <property type="entry name" value="nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041084">
        <property type="entry name" value="Ncstrn_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008710">
        <property type="entry name" value="Nicastrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092:SF0">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18266">
        <property type="entry name" value="Ncstrn_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05450">
        <property type="entry name" value="Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Nicastrin small lobe" evidence="16">
        <location>
            <begin position="60"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO20437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="718" mass="79637" checksum="2632A65458CDCF16" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7N1</accession>
    <name>A0A151M7N1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006361">
        <property type="protein sequence ID" value="KYO20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7N1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584783" description="Immunoglobulin V-set domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8000" checksum="598EAFB4545FE142" modified="2016-06-08" version="1">MLWQTQLFWLLMLWVQGSSGDNLVTQTPESLAASPGDTVTIKCKTSSSVISNMVMEKHQRGGLFGEEPTNQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9N3</accession>
    <name>A0A151M9N3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein 72</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">WDR72</name>
        <name evidence="2" type="ORF">Y1Q_0001492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9N3"/>
    <dbReference type="STRING" id="8496.A0A151M9N3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057848">
        <property type="entry name" value="WDR72_alpha-sol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23123">
        <property type="entry name" value="WDR72_alpha-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR72-like alpha-solenoid" evidence="1">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="139" mass="15749" checksum="B9712C5A364CCDF3" modified="2016-06-08" version="1">MSVQVSLAPVSVVKHDSCSNSANFQEAEDMPDRCVLEESESPDEMKSHPWMSKVTGDDNTEAYIEAFECHAIMTGLDKGYWANQLGALVVGKTQAAYRALPWDEAQDYDIVKAAILYRLEINPEHYRRFFWAKKGAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAF8</accession>
    <name>A0A151MAF8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0001678</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAF8"/>
    <dbReference type="STRING" id="8496.A0A151MAF8"/>
    <dbReference type="KEGG" id="amj:106736780"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07665">
        <property type="entry name" value="BAR_SNX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07281">
        <property type="entry name" value="PX_SNX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000015">
        <property type="entry name" value="Sorting nexin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000012">
        <property type="entry name" value="Sorting nexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034901">
        <property type="entry name" value="PX_SNX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028660">
        <property type="entry name" value="SNX1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005329">
        <property type="entry name" value="Sorting_nexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF129">
        <property type="entry name" value="SORTING NEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03700">
        <property type="entry name" value="Sorting_nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="139"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO21481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="518" mass="58726" checksum="9FFC33953026EB42" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBF8</accession>
    <name>A0A151MBF8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein kinase C and casein kinase substrate in neurons protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PACSIN3</name>
        <name evidence="16" type="ORF">Y1Q_0000461</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBF8"/>
    <dbReference type="STRING" id="8496.A0A151MBF8"/>
    <dbReference type="eggNOG" id="KOG2856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07681">
        <property type="entry name" value="F-BAR_PACSIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11997">
        <property type="entry name" value="SH3_PACSIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000014">
        <property type="entry name" value="Kinase C and casein kinase substrate in neurons protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000009">
        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF18">
        <property type="entry name" value="PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="F-BAR" evidence="15">
        <location>
            <begin position="88"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="453"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="385"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO21750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="514" mass="58073" checksum="12AB118C5F4EBB72" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBJ1</accession>
    <name>A0A151MBJ1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Palmitoyltransferase</fullName>
            <ecNumber evidence="16">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0000562</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="16"/>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBJ1"/>
    <dbReference type="STRING" id="8496.A0A151MBJ1"/>
    <dbReference type="KEGG" id="amj:102564289"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MBJ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000035">
        <property type="entry name" value="Palmitoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF16">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="17">
        <location>
            <begin position="422"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO21893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="619" mass="70376" checksum="C8E420C7B619359F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDM9</accession>
    <name>A0A151MDM9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-cell surface antigen CD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CD2</name>
        <name evidence="9" type="ORF">Y1Q_0003127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDM9"/>
    <dbReference type="STRING" id="8496.A0A151MDM9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015632">
        <property type="entry name" value="CD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF54">
        <property type="entry name" value="T-CELL SURFACE ANTIGEN CD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01870">
        <property type="entry name" value="CD2ANTIGEN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585037" evidence="7">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="8">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO22605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="320" mass="36793" checksum="3F8165EB268913FB" modified="2016-06-08" version="1">MNFKEIFLAKYLVILFFSVKGSFGEPARVSAVLNESVFLNISNPLDESAHDIRWFKDTNIIVKLVNSSEFYYSDKKKYYLFPNGTLKIEQLLEEDSGSYKVEVFCSDGTLKEQKDITLSTVVPVSQPLLTWDCTRKYLKLTCEVKQEPKPFSQLVRYEGKSLQATKEWKSTNGFWSMEYQEAKNASGKYTCIVSNSVTSKYDTKDIQCAGLDLLLILCIAGGAVVFVIILVLLIYYIRRKTVEHYEEEDDEDIPVQIYPVEDGMKQRELPRPPGHAPQRQPRQPQRPPPQSQPQAQQLAALPRPRPRTQQRAPNRIKERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEG1</accession>
    <name>A0A151MEG1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interferon alpha/beta receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IFNAR1</name>
        <name evidence="5" type="ORF">Y1Q_0003268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014454677.1">
        <property type="nucleotide sequence ID" value="XM_014599191.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEG1"/>
    <dbReference type="STRING" id="8496.A0A151MEG1"/>
    <dbReference type="GeneID" id="102567201"/>
    <dbReference type="KEGG" id="amj:102567201"/>
    <dbReference type="CTD" id="3454"/>
    <dbReference type="eggNOG" id="ENOG502RISU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9944680at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MEG1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004905">
        <property type="term" value="F:type I interferon receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000842">
        <property type="entry name" value="Interferon receptor 1 isoform 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF54">
        <property type="entry name" value="INTERFERON ALPHA_BETA RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01108">
        <property type="entry name" value="Tissue_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585073" evidence="3">
        <location>
            <begin position="26"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="344"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO22780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="569" mass="64127" checksum="1EBB64F2A01F7ADC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEJ8</accession>
    <name>A0A151MEJ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HEMK1</name>
        <name evidence="8" type="ORF">Y1Q_0005464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO22954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEJ8"/>
    <dbReference type="STRING" id="8496.A0A151MEJ8"/>
    <dbReference type="eggNOG" id="KOG2904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:peptide chain release factor N(5)-glutamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="RF_methyltr_PrmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Release factor glutamine methyltransferase N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase small" evidence="6">
        <location>
            <begin position="173"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO22954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="349" mass="39546" checksum="9FBA89A9B29A2637" modified="2016-06-08" version="1">MIMGLLPHWGPVRVNPIKSAALNSHQFLLRQNFSGKPGPVTATDLVNYWQEVFEANRIPEAQESSEYIVSYVLGAKTFHSLSASSMSTPLTAEQQEQVQQLSAKRLQRMPVQYVLGEWDFQDLTLKMRPPVFIPRPETEDLISLVLEEASQKNKSCVDNAVHQCPPTTPLLVILEIGCGSGAIALSLLSKLPQSQVIAVDKEVAAVNLTRENAQRFQLEHRLRLFHHDVLSSSWEQLLPWGPVDIIISNPPYVFHEDMAHLAAEILRYEHLDALDGGNDGMRVIKRILELAPYILKNYGSVFLEVDPRHPEMVENWLQSRPDLFLSLCATHKDFCGKPRFLHIQKTYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MG68</accession>
    <name>A0A151MG68_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0012736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006209">
        <property type="protein sequence ID" value="KYO23493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MG68"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05713">
        <property type="entry name" value="IgV_MOG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000183">
        <property type="entry name" value="Myelin-oligodendrocyte glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF149">
        <property type="entry name" value="BG-LIKE ANTIGEN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="64"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO23493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="192" mass="21690" checksum="FD3A160BF400B0A6" modified="2016-06-08" version="1">MSQNLSCWRTGTVIVKRLRSFDQIQDTMEKKVTSSLCLSSRASTSVTGLIIVCTCFCIRKLESAQFTVIGSAQPITAIVGQDIVLPCHLSPRMSAENMEVRWFRNYFDTFVHLYPDGRDQNGQQIPEYRGRTELLNSGIMNGNISLKIFNIERADEGQYHCFVQDETANAETALLLNIAVVPYSFLVYVMKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGR7</accession>
    <name>A0A151MGR7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGR7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="9896" checksum="BD83155C4EF7374E" modified="2016-06-08" version="1">MWQQEDIAQERVFQVELLAPEQECLQMLQAQYNILVQATEPMDNDHWTLDTILGLAVSCMLTTSWPLVLALQGPCKPPAAPQEASTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MH20</accession>
    <name>A0A151MH20_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MH20"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="86" mass="9915" checksum="4EE4B9E5A7ED9602" modified="2016-06-08" version="1">MNQTWFHHVMLQSPRNPGLIFVGRLEIWQCIVLSAFHSNPICTSIPVPLQLRLQLSSVCALRQTSKPAFQEFEQTPAQFNKPYSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHB3</accession>
    <name>A0A151MHB3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maestro heat-like repeat-containing protein family member 1 isoform F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MROH1L</name>
        <name evidence="7" type="ORF">Y1Q_0015869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF45">
        <property type="entry name" value="MAESTRO HEAT LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="5">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="4">
        <location>
            <begin position="233"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="3">
        <location>
            <begin position="912"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="6">
        <location>
            <begin position="1332"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1633"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1641"/>
            <end position="1657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO23889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1657" mass="188306" checksum="E866B67396C57944" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHJ0</accession>
    <name>A0A151MHJ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO23971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHJ0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10317" checksum="1A6F11D915C721B9" modified="2016-06-08" version="1">MVPDHTQSQQGVSPAKEMFWFWPECPFGASAVPGPQRCPKHYSDQKCPGSVASQERVWVRQQELLCVEDSTKVRTQILARAVPHQDTMDCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHN8</accession>
    <name>A0A151MHN8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WW domain-binding protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">WBP4</name>
        <name evidence="16" type="ORF">Y1Q_0004625</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO24042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHN8"/>
    <dbReference type="STRING" id="8496.A0A151MHN8"/>
    <dbReference type="eggNOG" id="KOG0150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000767">
        <property type="entry name" value="WW domain-binding protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="15">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="13">
        <location>
            <begin position="525"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO24042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="641" mass="73741" checksum="8B6CFADFD46C48CF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHQ5</accession>
    <name>A0A151MHQ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO24019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHQ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO24019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="144" mass="15839" checksum="D751195C29511187" modified="2016-06-08" version="1">MLGGALAGRVNQKDGMEREAMISSREGSDASRSEGEAVSSGKDKPALGQELQCREKRETKKETGETLGPVASEEKGETLVLLIASKQVGWWRDLVYVKRRLGGRGNIVKTQREGCRVVKTQREGNEIVRAQREGDNTEGPERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIY2</accession>
    <name>A0A151MIY2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">INTS10</name>
        <name evidence="7" type="ORF">Y1Q_0002091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15. The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to form the Integrator-PP2A (INTAC) complex. INTS10 is part of the tail subcomplex, composed of INTS10, INTS13, INTS14 and INTS15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006071">
        <property type="protein sequence ID" value="KYO24477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIY2"/>
    <dbReference type="STRING" id="8496.A0A151MIY2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026164">
        <property type="entry name" value="Int_cplx_su10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16055:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21045">
        <property type="entry name" value="INT10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02106">
        <property type="entry name" value="INTSUBUNIT10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO24477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="749" mass="86337" checksum="465562A62A4438BF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJH7</accession>
    <name>A0A151MJH7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Prolyl endopeptidase</fullName>
            <ecNumber evidence="10">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PREP</name>
        <name evidence="13" type="ORF">Y1Q_0017769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03006032">
        <property type="protein sequence ID" value="KYO24667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270313.1">
        <property type="nucleotide sequence ID" value="XM_006270251.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJH7"/>
    <dbReference type="STRING" id="8496.A0A151MJH7"/>
    <dbReference type="GeneID" id="102569802"/>
    <dbReference type="KEGG" id="amj:102569802"/>
    <dbReference type="CTD" id="5550"/>
    <dbReference type="eggNOG" id="KOG2237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000001">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000275">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="483"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO24667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="710" mass="80840" checksum="D06FF1B3166901BE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKK7</accession>
    <name>A0A151MKK7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM125</name>
        <name evidence="2" type="ORF">Y1Q_0012402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005990">
        <property type="protein sequence ID" value="KYO25064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261799.1">
        <property type="nucleotide sequence ID" value="XM_006261737.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKK7"/>
    <dbReference type="GeneID" id="102573950"/>
    <dbReference type="KEGG" id="amj:102573950"/>
    <dbReference type="CTD" id="128218"/>
    <dbReference type="eggNOG" id="ENOG502S0IK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8950495at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MKK7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028165">
        <property type="entry name" value="TMEM125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31416">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31416:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15109">
        <property type="entry name" value="TMEM125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="220" mass="23798" checksum="D3B083A53AAB7927" modified="2016-06-08" version="1">MPELEQLSAPRAPVDAGHIQRNLLEEHVELWWFQDPKRSILCYGVAVVLILACGAGGIVLLYSTSSRSGEWRLAVGTTLCLLALLVLLKQLLSSAIQDMNCIRSRDQIELLKSGGFSDCIMLLLSALVLLVCGVVLTILSTTTMQLSPARPLASMFTSGVVLVATGAAILFCLLLYLLWMSCCPPVPHDLDSRDISVFTISGQLATNRRLPATSSMANLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ML64</accession>
    <name>A0A151ML64_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005879">
        <property type="protein sequence ID" value="KYO25301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ML64"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11137" checksum="DF3C9C205FA613D8" modified="2016-06-08" version="1">MKELEGQCFIDLSSAPGWVSPGTEDTLGTCEGIVSKQGKNQLLQIRVPTKVLRSKGKVDPDMLQHRVCQAVDQAFEYSALTSNYMHFAQALLAQGTLPREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MM96</accession>
    <name>A0A151MM96_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial tRNA methylthiotransferase CDK5RAP1</fullName>
            <ecNumber evidence="8">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CDK5 activator-binding protein C42</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CDK5 regulatory subunit-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CDK5RAP1</name>
        <name evidence="19" type="ORF">Y1Q_0019563</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37068"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03005690">
        <property type="protein sequence ID" value="KYO25646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MM96"/>
    <dbReference type="STRING" id="8496.A0A151MM96"/>
    <dbReference type="eggNOG" id="KOG2492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00413">
        <property type="entry name" value="CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="17">
        <location>
            <begin position="72"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="216"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="16">
        <location>
            <begin position="473"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO25646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="555" mass="61564" checksum="1854CAC9AC34AE84" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMI2</accession>
    <name>A0A151MMI2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PDIK1L</name>
        <name evidence="15" type="ORF">Y1Q_0023561</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMI2"/>
    <dbReference type="STRING" id="8496.A0A151MMI2"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13977">
        <property type="entry name" value="STKc_PDIK1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000174">
        <property type="entry name" value="Serine/threonine-protein kinase PDIK1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000165">
        <property type="entry name" value="Serine/threonine-protein kinase PDIK1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF58">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PDIK1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO25732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="353" mass="39851" checksum="6430B9E4988E3C69" modified="2016-06-08" version="1">MRAAWGESLTLKMVSSQPKYDLIREVGRGSYGVVYEAVVRKTSARVAVKKIRCHAPENVELALREFWALSSIKSQHPNVIHLEECILQKDGMVQKMSHGSSSSLYLQLVETSLKGEIVFDPRSAYYLWFVMDFCDGGDMNEYLLSRKPSRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQSRMDASDLEPTLKVADFGLSKVCSASGQNPEEPVNVNKCFLSTACGTDFYMAPEVWEGHYTAKADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSMNARMKQLIKEMLAANPQDRPDAFELELRLVKIAFKDSSWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN35</accession>
    <name>A0A151MN35_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">T-box transcription factor TBX10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TBX10</name>
        <name evidence="8" type="ORF">Y1Q_0012248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005659">
        <property type="protein sequence ID" value="KYO25873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN35"/>
    <dbReference type="STRING" id="8496.A0A151MN35"/>
    <dbReference type="eggNOG" id="KOG3586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20187">
        <property type="entry name" value="T-box_TBX1_10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000006">
        <property type="entry name" value="T-box transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF102">
        <property type="entry name" value="T-BOX TRANSCRIPTION FACTOR TBX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO25873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="211" mass="24470" checksum="1DCF84F1CD6E273A" modified="2016-06-08" version="1">MRSLWEEFNRLGTEMIVTKAGRRMFPTFQVKLSGLDPLADYVLLMDFMPLDDKRYRYAFHSSSWLVAGRADPAAPGRVHFHPDSPAKGAQWMRQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVFVDPRQDSERFAHENFKSFTFTETQFMAVTAYQNHRITQLKIASNPFAKGFRDCEPEDWAAGFHALNVYTTSMTPALGYEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPT1</accession>
    <name>A0A151MPT1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular matrix protein FRAS1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FRAS1</name>
        <name evidence="3" type="ORF">Y1Q_0002171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPT1"/>
    <dbReference type="STRING" id="8496.A0A151MPT1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052624">
        <property type="entry name" value="CRIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46439">
        <property type="entry name" value="CYSTEINE-RICH MOTOR NEURON 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46439:SF1">
        <property type="entry name" value="CYSTEINE-RICH MOTOR NEURON 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585343" evidence="1">
        <location>
            <begin position="27"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="93"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="157"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="219"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="283"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="2">
        <location>
            <begin position="347"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO26547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="518" mass="56840" checksum="6548B6A9234BD52D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRL0</accession>
    <name>A0A151MRL0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">HLA class II histocompatibility antigen, DR alpha chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0003616</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MHC class II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005356">
        <property type="protein sequence ID" value="KYO27113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRL0"/>
    <dbReference type="STRING" id="8496.A0A151MRL0"/>
    <dbReference type="KEGG" id="amj:102568501"/>
    <dbReference type="eggNOG" id="ENOG502RXYJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8925804at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MRL0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002504">
        <property type="term" value="P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05767">
        <property type="entry name" value="IgC1_MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001003">
        <property type="entry name" value="MHC_II_a_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF86">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00993">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00920">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0491">MHC II</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585406" evidence="13">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="115"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO27113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="257" mass="29004" checksum="61B2CD61EB27726F" modified="2016-06-08" version="1">MAGGRVFPQAQLALITMLALQGTGAVKVDHVLSQVAYYQRTHPSTESGEFMFEFDNDEIFHVDLEKKETIWRLPDFGKFTSFEAQGALGNIAVLKKNMEIMIERSNRTRSQIVAPEVKVFSENPVELGEPNILICFVDKFSPPVLNITWLKNGKEMTDGVFETDFYPRQDNAFRKFTYLPFIPTTDDYYDCRVEHWGLAKPFLKHWEAQVPTPIPETTETVVCALGLAVGIIGIIAGTVLIMKGMKMNEARNPRGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRX5</accession>
    <name>A0A151MRX5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005226">
        <property type="protein sequence ID" value="KYO27278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRX5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO27278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="135" mass="15695" checksum="11057BFA30C1C741" modified="2016-06-08" version="1">MCHRQGTSPGFFGKRDSFVSKSIDRAGEIHQTRNLWRQCALDKRVALSIMKLATPARLHYITNQFSVDHCMASMVTYEHGSTLVHLKKSQPYWARNEDINVFYQQLEEEIEETHRNETIIIFGNFNVILRIGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTL1</accession>
    <name>A0A151MTL1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Delta(14)-sterol reductase TM7SF2</fullName>
            <shortName evidence="20">Delta-14-SR</shortName>
            <ecNumber evidence="20">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">3-beta-hydroxysterol Delta (14)-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Sterol C14-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Transmembrane 7 superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TM7SF2</name>
        <name evidence="21" type="ORF">Y1Q_0006903</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>4,4-dimethyl-8,14-cholestadien-3beta-ol + NADPH + H(+) = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46812"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
            <dbReference type="ChEBI" id="CHEBI:87044"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>5alpha-cholest-8,14-dien-3beta-ol + NADPH + H(+) = 5alpha-cholest-8-en-3beta-ol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46456"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:86131"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Microsome membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="20"/>
    <dbReference type="EMBL" id="AKHW03005076">
        <property type="protein sequence ID" value="KYO27850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006265025.1">
        <property type="nucleotide sequence ID" value="XM_006264963.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014452006.1">
        <property type="nucleotide sequence ID" value="XM_014596520.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTL1"/>
    <dbReference type="STRING" id="8496.A0A151MTL1"/>
    <dbReference type="GeneID" id="102560387"/>
    <dbReference type="KEGG" id="amj:102560387"/>
    <dbReference type="CTD" id="7108"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="UniPathway" id="UPA00063"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000001">
        <property type="entry name" value="delta(14)-sterol reductase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="5 20" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO27850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="418" mass="46435" checksum="30793E8CB0B970F9" modified="2016-06-08" version="1">MDRYRVPRTKEMEFGGALGTAALTLLLPGAMWYLLTACGTKEASVLQVPPVPTPRTLANPQALLLVLAWLGLQAALHMLPMGKVTEGIILRDKTRLQYRVNAFQVLGLTALGVGAGLAAGLRLSFIHDHLLELAGAATLVSFGLSLLLYLKALLASEAALAPGGNSGNPIYDFFMGHELNPRVGSFDLKYFCELRPGLIGWALVNLAMLLKETELRGSPSLAMVLVNAFQLLYVVDALWNEEAVLTTMDIVHDGFGFMLVFGDLAWVPFTYSLQAYFLVGHPQHLGLPAAVAILLLNGLGYYIFRSANSQKNTFRRNPNDPRVAGLKTIPTATGRRLLASGWWGFVRHPNYLGDIIMALAWSLPCGLTHVLPYFYVIYFTMLLIHREARDERQCLRKYGLAWEEYCRQVPYRIFPYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV01</accession>
    <name>A0A151MV01_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G-protein coupled receptor 176 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GPR176</name>
        <name evidence="11" type="ORF">Y1Q_0015935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV01"/>
    <dbReference type="STRING" id="8496.A0A151MV01"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="80"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO28325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="541" mass="61282" checksum="938B937E99534168" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV12</accession>
    <name>A0A151MV12_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cdc42 effector-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0015965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV12"/>
    <dbReference type="KEGG" id="amj:102572569"/>
    <dbReference type="eggNOG" id="ENOG502S89I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9447768at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031274">
        <property type="term" value="P:positive regulation of pseudopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029273">
        <property type="entry name" value="Cdc42_effect-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051296">
        <property type="entry name" value="Cdc42_Effector_BORG/CEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15344">
        <property type="entry name" value="CDC42 EFFECTOR PROTEIN BORG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15344:SF8">
        <property type="entry name" value="GENE 14137-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14957">
        <property type="entry name" value="BORG_CEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc42 effector-like" evidence="2">
        <location>
            <begin position="67"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO28360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="179" mass="20510" checksum="BD0C95C543F9AED0" modified="2016-06-08" version="1">MDTWRRGSIKSSTFFKRFSLRRHKKLGNQVIILNQNSNTIDNDGQYHKRELRDLKDKSEYLSCQSEQNLAKAQAPPKPPRLYLDSSSCPNIIDHTDSPSKDVSFSSANHQYHKATQTQQAHIHKDQATDWGTAERGSQTGSPLYDPSDPFFSFKVDLGLSLLEDVLQTLRKQNPRDYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYY9</accession>
    <name>A0A151MYY9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004558">
        <property type="protein sequence ID" value="KYO29665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYY9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="11250" checksum="A92C752F9272CF60" modified="2016-06-08" version="1">MVSAVSSQMERGHQEDLVQGQVDRGMPDILLFLWAKYTSQICKLATDTIQNHLPGEIFCRAHPDLLGGVHPDQPQTAGRDKWNWGQRQQQRVRQQELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZE4</accession>
    <name>A0A151MZE4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone deacetylase 11</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HDAC11</name>
        <name evidence="15" type="ORF">Y1Q_0023188</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with HDAC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZE4"/>
    <dbReference type="STRING" id="8496.A0A151MZE4"/>
    <dbReference type="eggNOG" id="KOG1344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09993">
        <property type="entry name" value="HDAC_classIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000009">
        <property type="entry name" value="Histone deacetylase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044150">
        <property type="entry name" value="HDAC_classIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="89"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO29848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="402" mass="44561" checksum="103FFB559CBE0F29" modified="2016-06-08" version="1">MCTHVHPLHITPGVCLAKRLTATVGPELPPCCRPPACQQLASVTPGLDLGPSSPRPHRTELYHDVPSACWPIVYSPDYNITFMGLEKLHPFDAGKWGKVINFLKEEKLIADDLIVQAREATEEDLLVVHTRRYLNKLKWSFVVATITEVPPLFFLPNFFVQRKVLKPLRTQTGGTIMAGKLAIDRGWAINVGGGFHHCSSDKGGGFCAYADITLAIKFLFERVEGVSKATIIDLDAHQGNGHERDFMDDQRVYIMDVYNRYIYPGDGFAKRAIKRKIELDGGTEDTEYLQKVQTHVEGALNESRPDIIIYNAGTDILDGDPLGGLAISPQGIVKRDEIVFMAARSRRIPILMVTSGGYQKRTARIIADSILNLHNLRLINKELATRGAENPKAAGRVSAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N250</accession>
    <name>A0A151N250_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AP complex mu/sigma subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0006551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004119">
        <property type="protein sequence ID" value="KYO30906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N250"/>
    <dbReference type="STRING" id="8496.A0A151N250"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585663" description="AP complex mu/sigma subunit domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="2">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO30906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="120" mass="12913" checksum="F85DDC61C39130E5" modified="2016-06-08" version="1">MPAPTGWFSMRYLVQSTLACPHVLVRDLAWSQGCSSCPLPGLVHYILQEVVMGGMVLETNMNEIVAQIDAQSKLEKSEGGLSAAPARAVSAVKNINLPELPRNINIGDINIKVPSLSPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2J9</accession>
    <name>A0A151N2J9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterile alpha motif domain-containing protein 9-like isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SAMD9L</name>
        <name evidence="2" type="ORF">Y1Q_0016381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N2J9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="entry name" value="Schlafen, AAA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16155">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16155:SF3">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 9-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1552" mass="178627" checksum="AFFA8842CAECB709" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2X9</accession>
    <name>A0A151N2X9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="12">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SRP68</name>
        <name evidence="14" type="ORF">Y1Q_0016517</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2X9"/>
    <dbReference type="STRING" id="8496.A0A151N2X9"/>
    <dbReference type="eggNOG" id="KOG2460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000001">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO31186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="597" mass="67761" checksum="DB15FB28E4131202" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2Y8</accession>
    <name>A0A151N2Y8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial thiamine pyrophosphate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SLC25A19</name>
        <name evidence="15" type="ORF">Y1Q_0016490</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>thiamine phosphate(out) + thiamine diphosphate(in) = thiamine phosphate(in) + thiamine diphosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:73383"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2Y8"/>
    <dbReference type="STRING" id="8496.A0A151N2Y8"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042723">
        <property type="term" value="P:thiamine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="114"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="212"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO31142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="316" mass="34830" checksum="E85E771F2AE86EF6" modified="2016-06-08" version="1">MVGYDPRAESVPAAAAALAGSASGLVTRALISPLDVIKIRFQLQIEQLSSSHPLAKYHGIVQAARRISREEGWAAFWKGHVPAQLLSISYGAVQFVAFEGLTELVHTATPYNARDFSVHFVCGGLSACTATMTVQPLDTLRTRFAAQGEPKVYRNLRHAVGTMYKTEGLLTFYRGLTPTVIAVFPYAGLQFSSYNILQQMYEWVIPAEEKKAGNLRNLVCGSCAGVMSKTLTYPFDLFKKRLQVGGFEQARAAFGQVRTYRGFMDCATQIVQEEGPSGFFKGLSPSLLKAAFSTGFTFFWLCRTRSVHRKTPNRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4W1</accession>
    <name>A0A151N4W1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium/glucose cotransporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">High affinity sodium-glucose cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 5 member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0022763</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-galactose(out) + 2 Na(+)(out) = D-galactose(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70499"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:70500"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70495"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70496"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4W1"/>
    <dbReference type="STRING" id="8496.A0A151N4W1"/>
    <dbReference type="KEGG" id="amj:102560322"/>
    <dbReference type="eggNOG" id="KOG2349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N4W1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000005">
        <property type="entry name" value="sodium/glucose cotransporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF151">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO31655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="647" mass="71247" checksum="5ABA0929703B5ABA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N665</accession>
    <name>A0A151N665_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Synaptotagmin-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SYT11</name>
        <name evidence="15" type="ORF">Y1Q_0000381</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003945">
        <property type="protein sequence ID" value="KYO32312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006271670.1">
        <property type="nucleotide sequence ID" value="XM_006271608.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N665"/>
    <dbReference type="STRING" id="8496.A0A151N665"/>
    <dbReference type="GeneID" id="102562498"/>
    <dbReference type="KEGG" id="amj:102562498"/>
    <dbReference type="CTD" id="23208"/>
    <dbReference type="eggNOG" id="KOG1028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N665"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903531">
        <property type="term" value="P:negative regulation of secretion by cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08388">
        <property type="entry name" value="C2A_Synaptotagmin-4-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08404">
        <property type="entry name" value="C2B_Synaptotagmin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000039">
        <property type="entry name" value="Synaptotagmin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000051">
        <property type="entry name" value="Synaptotagmin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF115">
        <property type="entry name" value="SYNAPTOTAGMIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="156"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="290"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO32312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="429" mass="47937" checksum="7AE666F1D970EE75" modified="2016-06-08" version="1">MAEITSVQPGLDVSPVVAGLIGATVLVVSVSVTVFVWTCCHQQAEKKHKNPPYKFIHMLKGISIYPETLSNKKKINRIRRDKNGTAKDTGKGNLLVDAAEAGLLGSEKTPDGLNATPCVDQLPIKMDFGDELSPDQSLTPGGSKTSSPSSPEEDVLLGELTFSVDYNFPKKALVVTIQEAHGLPMMDEHTQSSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTREIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSDPYVKVNVYYGRKRIAKKKTHVKKCTLNPVFNESFIYDIPVDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSITTAGVEHWREVCENPRKPVAKWHSLSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6C4</accession>
    <name>A0A151N6C4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAM16</name>
        <name evidence="9" type="ORF">Y1Q_0020347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6C4"/>
    <dbReference type="STRING" id="8496.A0A151N6C4"/>
    <dbReference type="GeneID" id="102574404"/>
    <dbReference type="KEGG" id="amj:102574404"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO32386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="125" mass="13884" checksum="A63AB021A9A1B7A7" modified="2016-06-08" version="1">MARYLAQIVVLGAQVLGRAFALALRQEFAASRAAAEARGRGRPLSAAESRVAGISLQEAKQILNVSSLAPEEIQKNYEHLFKVNDKSLGGSFYVQSKVLRAKERLDEELWIQAQSQKEEEQKPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N743</accession>
    <name>A0A151N743_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003905">
        <property type="protein sequence ID" value="KYO32571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N743"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9229" checksum="CBAC225DB0FAA1E8" modified="2016-06-08" version="1">MCSLESSFPQDGLVIKALGSGELGSFSGPAKDFPCDLKQGSQEEIFKDTKGRRSSWSPFPVNYPPVGLPVLTDKKTDLPQLNKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7E8</accession>
    <name>A0A151N7E8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7E8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10208" checksum="70718452A1E71844" modified="2016-06-08" version="1">MLKQEKWSRTKKLLSGALDIRAIFVVRLEGLQFFKVPEDYKSDIMPLTSSAKNSPQGPVSRDILLNRLDSVTAFAFFSVLLQPSITGSDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8S5</accession>
    <name>A0A151N8S5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA damage-regulated autophagy modulator protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DRAM2</name>
        <name evidence="9" type="ORF">Y1Q_0014994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8S5"/>
    <dbReference type="STRING" id="8496.A0A151N8S5"/>
    <dbReference type="eggNOG" id="KOG4320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF10">
        <property type="entry name" value="DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585839" evidence="7">
        <location>
            <begin position="35"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="8">
        <location>
            <begin position="62"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="319" mass="36043" checksum="2DDB4AD2748DAC5E" modified="2016-06-08" version="1">MPPSPVELGGARLSPAPLWCLLHLLWCQIRIPSGIDPQVDQYFQQLDLGENTEMWWFQQGLCFLPSALVIWTAASFIFPYITAIFLRHVDPLVPYISDTGIMPPERCLFGIMLNISTSLCIATMYVRYKQVCALNPEKTKIAKLNKTGFILGVISCFGICLITNFQKSVMYTVHVLGAALTFGIGTFYLLIQTILSYMMQPDIHGKEIFWIRLTLLLWCVSSLLSMAISTIFLLSGRYGTGLEQKLHWNPEEKGYAVHIISTVSEWSLAFSFLSFFLTYIRDFQKVSLRATVNLDGQTLYDTPHSLMTDENPLLISGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N906</accession>
    <name>A0A151N906_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N906"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="102" mass="10905" checksum="420E53B1D4F3BEA9" modified="2016-06-08" version="1">MSDLTWDCSRDLYGTQPEMSLPSTPVNPRILVPDTQDDRQQGTRNNSSVHDEEEDSDSGSQVSPVLETPQDSQTVTSTPSTAAVMNDTAAGGPQLSGGAPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAC5</accession>
    <name>A0A151NAC5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PTB domain-containing engulfment adapter protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cell death protein 6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">PTB domain adapter protein CED-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GULP1</name>
        <name evidence="11" type="ORF">Y1Q_0008852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ced-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAC5"/>
    <dbReference type="STRING" id="8496.A0A151NAC5"/>
    <dbReference type="KEGG" id="amj:102572520"/>
    <dbReference type="OrthoDB" id="10057585at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NAC5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01273">
        <property type="entry name" value="PTB_CED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000118">
        <property type="entry name" value="GULP PTB domain containing engulfment adaptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF77">
        <property type="entry name" value="GULP PTB DOMAIN CONTAINING ENGULFMENT ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="10">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="304" mass="34372" checksum="609134CEF4216F2D" modified="2016-06-08" version="1">MNRAFSRKKDKSWMHTPEALSKHYIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKTPKVELQISIYGVKILDPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQELETENIELKNKVQDLENQLRINQVHTSPAGSVTPKSPSTDIFDMVPFSPISPQSSTPTRNGTQPPPVPSRSAEIKRDLFGAEPFDPFSCGAGEFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCR8</accession>
    <name>A0A151NCR8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003390">
        <property type="protein sequence ID" value="KYO34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCR8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="7945" checksum="F01BFC3B9A00E29B" modified="2016-06-08" version="1">MHTDATGSSSPGTGQCTVLGSLRLEEEEHRGAESRGCLKDAQHRDRRGYDIVVTSGREADPQVTMIAGPFCKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEA4</accession>
    <name>A0A151NEA4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polypyrimidine tract-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PTBP3</name>
        <name evidence="17" type="ORF">Y1Q_0001033</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014451832.3">
        <property type="nucleotide sequence ID" value="XM_014596346.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059580604.1">
        <property type="nucleotide sequence ID" value="XM_059724621.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059580605.1">
        <property type="nucleotide sequence ID" value="XM_059724622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEA4"/>
    <dbReference type="STRING" id="8496.A0A151NEA4"/>
    <dbReference type="GeneID" id="106737115"/>
    <dbReference type="KEGG" id="amj:106737115"/>
    <dbReference type="CTD" id="9991"/>
    <dbReference type="eggNOG" id="KOG1190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NEA4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903312">
        <property type="term" value="P:negative regulation of mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12779">
        <property type="entry name" value="RRM1_ROD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12784">
        <property type="entry name" value="RRM2_ROD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12703">
        <property type="entry name" value="RRM4_ROD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000036">
        <property type="entry name" value="polypyrimidine tract-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000162">
        <property type="entry name" value="polypyrimidine tract-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000018">
        <property type="entry name" value="Polypyrimidine tract-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000032">
        <property type="entry name" value="Polypyrimidine tract-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033110">
        <property type="entry name" value="PTBP3_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034326">
        <property type="entry name" value="ROD1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="151"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="327"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="444"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="521" mass="56375" checksum="210ABD7DB4C1D242" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFI2</accession>
    <name>A0A151NFI2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leukocyte elastase inhibitor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Serpin B1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SERPINB5-1</name>
        <name evidence="7" type="ORF">Y1Q_0008101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family. Ov-serpin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFI2"/>
    <dbReference type="STRING" id="8496.A0A151NFI2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19956">
        <property type="entry name" value="serpinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000001">
        <property type="entry name" value="Serine protease inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000001">
        <property type="entry name" value="Serpin family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000014">
        <property type="entry name" value="Serpin family B member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000240">
        <property type="entry name" value="Serpin_B9/Maspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF199">
        <property type="entry name" value="SERPIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00676">
        <property type="entry name" value="MASPIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="56"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="391"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00073281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00079383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO35548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="837" mass="94739" checksum="38046F7DB35C02F9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFJ1</accession>
    <name>A0A151NFJ1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CTDP1</name>
        <name evidence="13" type="ORF">Y1Q_0007995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFJ1"/>
    <dbReference type="STRING" id="8496.A0A151NFJ1"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000017">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000040">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000007">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058785">
        <property type="entry name" value="BSH_FCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015388">
        <property type="entry name" value="FCP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26077">
        <property type="entry name" value="BSH_Fcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09309">
        <property type="entry name" value="FCP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="140"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="611"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="522"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="740"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="801"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="847"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="931"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="956" mass="106356" checksum="A4CE396E6FACBABE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFX2</accession>
    <name>A0A151NFX2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Counting factor associated protein D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0013852</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003146">
        <property type="protein sequence ID" value="KYO35650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFX2"/>
    <dbReference type="KEGG" id="amj:102559490"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000087">
        <property type="entry name" value="Counting factor associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018760463" evidence="7">
        <location>
            <begin position="17"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="325"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO35650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="543" mass="61097" checksum="8C2BB1CE693A48A1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFZ5</accession>
    <name>A0A151NFZ5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MRS2</name>
        <name evidence="18" type="ORF">Y1Q_0008018</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix and regulates magnesium metabolism. Also permeable to calcium, sodium and potassium ions. Required for normal expression of the mitochondrial respiratory complex I subunits. May play a role in maintaining the inner mitochondrial membrane potential.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFZ5"/>
    <dbReference type="STRING" id="8496.A0A151NFZ5"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000007">
        <property type="entry name" value="Magnesium transporter MRS2 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000003">
        <property type="entry name" value="Magnesium transporter MRS2 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO35445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="528" mass="59922" checksum="647355C1B47D6D51" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHH5</accession>
    <name>A0A151NHH5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003035">
        <property type="protein sequence ID" value="KYO35955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHH5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053819">
        <property type="entry name" value="TEADIR3_omega_loop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15238">
        <property type="entry name" value="TEADIR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="198" mass="22646" checksum="FC0A26EDAF7AB3AE" modified="2016-06-08" version="1">MTLQLLRFSELISSDIQRYFGRKDKEEDPDSCNIYEDCFSPQRSGRELYYADLMHIAQSGELDDEDSHSAQVPLGQLDQQVWRSICNKDGGQKLGPLAELFEYGLRQYIKQTVSDSRRLRLEKKYAHITPMHRRKLPPSFWKEPSPGPAGILNTNTPDFSDLLANWTVEPGQELPNASRELAGELGRQAMEADQFNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIR7</accession>
    <name>A0A151NIR7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Islet amyloid polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IAPP</name>
        <name evidence="9" type="ORF">Y1Q_0024362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcitonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019345151.1">
        <property type="nucleotide sequence ID" value="XM_019489606.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIR7"/>
    <dbReference type="STRING" id="8496.A0A151NIR7"/>
    <dbReference type="GeneID" id="102565065"/>
    <dbReference type="KEGG" id="amj:102565065"/>
    <dbReference type="CTD" id="3375"/>
    <dbReference type="eggNOG" id="ENOG502S4AQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9898100at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NIR7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021117">
        <property type="entry name" value="Calcitonin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021116">
        <property type="entry name" value="Calcitonin/adrenomedullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018360">
        <property type="entry name" value="Calcitonin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001693">
        <property type="entry name" value="Calcitonin_peptide-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000443">
        <property type="entry name" value="IAPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10505">
        <property type="entry name" value="CALCITONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10505:SF4">
        <property type="entry name" value="ISLET AMYLOID POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00214">
        <property type="entry name" value="Calc_CGRP_IAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00818">
        <property type="entry name" value="ISLETAMYLOID"/>
    </dbReference>
    <dbReference type="SMART" id="SM00113">
        <property type="entry name" value="CALCITONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00258">
        <property type="entry name" value="CALCITONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586102" evidence="7">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Calcitonin peptide-like" evidence="8">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="79"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR621116-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO36692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="133" mass="14750" checksum="72C322312039D4DE" modified="2016-06-08" version="1">MCNLKLPVVFIILSVTLSYLEATPIERLLSVADDLSDGTSNRQGWILPVMSRNALLGFSEGMPKQAGKLKSHRLEKRKCNTATCVTQRLADFLVRSSNHIGAIYSPTNVGSNTYGKRDRVGLLNREPLSYLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJ13</accession>
    <name>A0A151NJ13_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJ13"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO36793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17929" checksum="EADB8FE6EA2C64F6" modified="2016-06-08" version="1">MAFPEKGAGIHEDQLCGVQRRQIHRALVQLRDTLQLEREKRQSIAVLNLDLAKAYDKVSRDVQINDFLSTWIAVESGVWQDCPLSPILFICTIKPLAQHLRQDPGIRGVHIPGSSNREAKVFSVSLLVKAFYLLQTLTLGSCTVMVKPAYWINTISASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLF3</accession>
    <name>A0A151NLF3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Disks large-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0004749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002623">
        <property type="protein sequence ID" value="KYO37641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLF3"/>
    <dbReference type="STRING" id="8496.A0A151NLF3"/>
    <dbReference type="eggNOG" id="KOG3971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NLF3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099572">
        <property type="term" value="C:postsynaptic specialization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF3">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="790"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO37641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="864" mass="97083" checksum="9CCDE45612ED45F2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLP5</accession>
    <name>A0A151NLP5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein aurora borealis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BORA</name>
        <name evidence="7" type="ORF">Y1Q_0017222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BORA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLP5"/>
    <dbReference type="STRING" id="8496.A0A151NLP5"/>
    <dbReference type="eggNOG" id="ENOG502S85H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023252">
        <property type="entry name" value="Aurora_borealis_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14728">
        <property type="entry name" value="PROTEIN AURORA BOREALIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14728:SF2">
        <property type="entry name" value="PROTEIN AURORA BOREALIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15280">
        <property type="entry name" value="BORA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02038">
        <property type="entry name" value="AURORABORA"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="667" mass="73922" checksum="9E75D93506898F49" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLX2</accession>
    <name>A0A151NLX2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">All-trans retinoic acid-induced differentiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ATRAID</name>
        <name evidence="2" type="ORF">Y1Q_0017345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002621">
        <property type="protein sequence ID" value="KYO37669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NLX2"/>
    <dbReference type="eggNOG" id="ENOG502S1YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042350">
        <property type="entry name" value="ATRAID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15926">
        <property type="entry name" value="ALL-TRANS RETINOIC ACID-INDUCED DIFFERENTIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15926:SF1">
        <property type="entry name" value="ALL-TRANS RETINOIC ACID-INDUCED DIFFERENTIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="213" mass="23274" checksum="1618E25A5128E11D" modified="2016-06-08" version="1">MLFRPPRKRLPAHKASWEKKKSALEVPAPRAPRSAPLLSVRRRARVRARGRWRCCCSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRGRCCLDPPRLLGLDMGSCNRTSLCPGFQDASTAVVIDLTENPLEKLPDASFLGFTSLQSIAVPLALDCPGGSAAWENITAGADSRLCQGQRNACNSSGELAWLCPENSHACAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NM76</accession>
    <name>A0A151NM76_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neuromedin-U receptor 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NMUR2-1</name>
        <name evidence="16" type="ORF">Y1Q_0010981</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for the neuromedin-U and neuromedin-S neuropeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002664">
        <property type="protein sequence ID" value="KYO37585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NM76"/>
    <dbReference type="STRING" id="8496.A0A151NM76"/>
    <dbReference type="GeneID" id="102573226"/>
    <dbReference type="KEGG" id="amj:102573226"/>
    <dbReference type="CTD" id="56923"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NM76"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005392">
        <property type="entry name" value="NeuromedU_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045561">
        <property type="entry name" value="NMU-R2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF14">
        <property type="entry name" value="NEUROMEDIN-U RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19285">
        <property type="entry name" value="NmU-R2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01567">
        <property type="entry name" value="NEUROMEDNU2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="60"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO37585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="396" mass="45021" checksum="D40D1D9F706BAC73" modified="2016-06-08" version="1">MDWITNVSWLDHLAGKEEPLRWHLNSTEDYLAFLCGPKRSHLFVPMSLIYALIFVVGVVGNLLVCLVIIKHRNMKTPTNYYLFSLAISDLLVLVFGMPLEVYEMWSNYPFLFGPVGCYFKTALFETVCFASILSVTTVSMERYVAILHPFRAKLESTRKRALRIIIVLWVLSVLFSLPNTSTHGILLQRFPNGTLVPGSATCTVVMPMWIYNCIIQVTSFLFYVLPVAIISVLYYLMGLKLRGDKSLEAEEMTVNIQRPSRKSVTKMLFVLVMVFAVCWAPFHIDRLFFSFVVDWTEPLANVFNLIHVLSGVFFYLSSAVNPIIYNLLSRRFRLAFLNVITPRCKLWATKQPASRIPAHQSLFLVGDCNLMDSAENASPPSTHRMSVCSSRLSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNA6</accession>
    <name>A0A151NNA6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phosphatidylinositol-binding clathrin assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PICALM</name>
        <name evidence="24" type="ORF">Y1Q_0015537</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Binds to clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. Interacts with PIMREG; this interaction may change the subcellular location into the nucleus. Interacts with AP2A1 (via its alpha-appendage domain). Interacts (via N-terminus) with VAMP2; VAMP3; VAMP7 and VAMP8 (Via N-terminus). Interacts with LC3/MAP1LC3A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <location evidence="5">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNA6"/>
    <dbReference type="STRING" id="8496.A0A151NNA6"/>
    <dbReference type="GeneID" id="102574632"/>
    <dbReference type="KEGG" id="amj:102574632"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16985">
        <property type="entry name" value="ANTH_N_AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000001">
        <property type="entry name" value="phosphatidylinositol-binding clathrin assembly protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000001">
        <property type="entry name" value="phosphatidylinositol-binding clathrin assembly protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF11">
        <property type="entry name" value="ENTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0168">Coated pit</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="23">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO38264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="669" mass="72948" checksum="11D450519548A459" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNF3</accession>
    <name>A0A151NNF3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNF3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="16760" checksum="3426BAFC55266D24" modified="2016-06-08" version="1">MPFVRQVSCAHVSGDERVKAKSDQDLTLSFQQLSQILAQEIEYPCRLLAQKVHLGIAWKESGFTFHLGIGSKEEEDKIHKTDNGKENSMQHPSVTWKPHSVMEKIYQRWANHTKFKMFSSEKNATVSKTLEFPKLDWKSHENTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSN5</accession>
    <name>A0A151NSN5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0006736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSN5"/>
    <dbReference type="STRING" id="8496.A0A151NSN5"/>
    <dbReference type="eggNOG" id="ENOG502SI4A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000015">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO39872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="204" mass="22538" checksum="70E93C1A552A3F9C" modified="2016-06-08" version="1">MTECLLLAVMAYDRFVAICIPLHYTIIMNGKVCMKLAAASWTITLIPVLIPVGTPQKRLCGHNVINHFTCELQVLLKLVCSDTSDSEIIMRISGPLLLVVPFVFIMATYAHIGVAMLRIRSAQGRIKAFSTCSSHLAVVGIFYGTAMSIYLRPQTKSVSDQDKLISVFYGSVTPLLNPLIYSLRNKDVHGALKRTFAKAKSVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU56</accession>
    <name>A0A151NU56_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin-like proteiny domain-containing family A member 1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PLEKHA1-1</name>
        <name evidence="3" type="ORF">Y1Q_0009500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NU56"/>
    <dbReference type="STRING" id="8496.A0A151NU56"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13271">
        <property type="entry name" value="PH2_TAPP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000049">
        <property type="entry name" value="pleckstrin homology domain-containing family A member 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF4">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="151"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO40452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="358" mass="40243" checksum="74A8584CB8C12504" modified="2016-06-08" version="1">MDNPQNLPAGSPPVGALKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNILNKATKITVPKQSDSLCQSDNPNRQIESPAGKKQVSYRTEIVGGVPIITPTQKEELNDCGEGGDRNYLKRSQSHLPYFTAKHPSDNAVIKAGYCVKQGAVMKNWKRRYFQLDENAIRYFKSELEKEPLRLIPLKEVHKVQECKQSDIMMRDNLFEIVTASRTFYVQADSPEDMHSWIKAISGAIVAQRGPGRSAASMRQARRLSNPCIQRYTSRTGECSTSIPTLLQNTAALSVLPTPQQPPHIPQPLATTVWSPTLTPNTLSWRSEDFTNLLPRPSQGTTRSRLSLQENQLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NV21</accession>
    <name>A0A151NV21_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001862">
        <property type="protein sequence ID" value="KYO40762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NV21"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF11">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="171" mass="19527" checksum="8BA09F689EBA92D8" modified="2016-06-08" version="1">MELEAQCECEKPQHGVKAQGEEAKRQEREKTAQHQEAEAQRKHEPEVLRLQPNGGDAGPSQAPRGHPKPNSSAFSRYQVGDDPDVFLSIFEKQARRWKVPDEEFMMHMAALVEGNVAVVLNNLPMEQAVDYKTFKEAVQLRFNLGSEFFHNRFRTTVPQGIWESPCTNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWK7</accession>
    <name>A0A151NWK7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0007006</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001653">
        <property type="protein sequence ID" value="KYO41257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWK7"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000380">
        <property type="entry name" value="zinc finger protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000292">
        <property type="entry name" value="zinc finger protein 619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001011">
        <property type="entry name" value="Zinc finger protein 793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000102">
        <property type="entry name" value="zinc finger protein 850 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000496">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF435">
        <property type="entry name" value="ZINC FINGER PROTEIN 59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="746"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="841"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="925"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="953"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="981"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1009"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1037"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1065"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1093"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1121"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1149"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="426"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="593"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO41257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131133" checksum="FE939290694D45DB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXM8</accession>
    <name>A0A151NXM8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Synaptotagmin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0006330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXM8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF175">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO41558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="234" mass="26564" checksum="8573C8D99781D2BA" modified="2016-06-08" version="1">MCQLWKPSRLGKKRKCLSEAWNGIKTEDGILRKNIQPSLLDIAQKSYSCVKIQKLKEELDKLGTCLSPSSTSSENLDNMGSNVEVPDNSRARLRFSILYHRERLELFLMVIEATGLPSQRSTDYAVWVKGESEVKHFNKYSRHTVLGEVRVTLSQLKSCWSMEFCEELQKTTKNIVGEVLVSLKCLPISQRIEVGLLKARTASLCSCPDKSKGCHLRINKVAQIFTMKLEPDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYJ7</accession>
    <name>A0A151NYJ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RISC-loading complex subunit TARBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">TARBP2</name>
        <name evidence="11" type="ORF">Y1Q_0002613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TARBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO41946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019339975.1">
        <property type="nucleotide sequence ID" value="XM_019484430.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYJ7"/>
    <dbReference type="STRING" id="8496.A0A151NYJ7"/>
    <dbReference type="GeneID" id="102559811"/>
    <dbReference type="CTD" id="6895"/>
    <dbReference type="eggNOG" id="KOG3732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10056847at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070883">
        <property type="term" value="F:pre-miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098795">
        <property type="term" value="P:global gene silencing by mRNA cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903798">
        <property type="term" value="P:regulation of miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070921">
        <property type="term" value="P:regulation of siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046782">
        <property type="term" value="P:regulation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070922">
        <property type="term" value="P:RISC complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19890">
        <property type="entry name" value="DSRM_TARBP2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10844">
        <property type="entry name" value="DSRM_TARBP2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19893">
        <property type="entry name" value="DSRM_TARBP2_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000120">
        <property type="entry name" value="RISC-loading complex subunit TARBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000018">
        <property type="entry name" value="RISC-loading complex subunit TARBP2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03034">
        <property type="entry name" value="TRBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028605">
        <property type="entry name" value="TRBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044469">
        <property type="entry name" value="TRBP2_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044470">
        <property type="entry name" value="TRBP2_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044471">
        <property type="entry name" value="TRBP2_DSRM_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF1">
        <property type="entry name" value="RISC-LOADING COMPLEX SUBUNIT TARBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4 7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="158"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="289"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO41946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="362" mass="38775" checksum="610758B7C00E4E73" modified="2016-06-08" version="1">MSEGEEEEEPRATASGACPSLEQMLASNPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDIGCTGQGPSKKAAKHKAAEVALKLLKGGNMLEPAVPEEPSSAFSLEPLPPLDPAVAPPAPALPAASPRSSPLEMKAPVSPQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFMEIGSGTSKKLAKRNAAAKMLVRIHNVPMEQREGSEAEAEDDQFSIAPVPKLDGLRGRLPGCTWDSLRNSVGEKILHLRSQPLGALSPGYCGLLQELSEEQSFAISYLDIAEQSLSGLYQCLVELSTQPTTVCHGTAPSRDAARADAARNALQYLKIMAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZE1</accession>
    <name>A0A151NZE1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidative stress-responsive serine-rich protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Oxidative stress-responsive protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Peroxide-inducible transcript 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">OSER1</name>
        <name evidence="6" type="ORF">Y1Q_0002775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZE1"/>
    <dbReference type="eggNOG" id="ENOG502QUK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008494">
        <property type="entry name" value="DUF776"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383:SF2">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSIVE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05604">
        <property type="entry name" value="DUF776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO42144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="288" mass="31967" checksum="F06BA5668021FA46" modified="2016-06-08" version="1">MMKTEAKDGEEESLQTAFKKLRVDTASSIAALSVKGEGTSTRALVRTTTDESKPKTTCASKETWHGSMRKPSRGAVRTQRRRRSKSPILPPKFIHCSTKPPSTCSQLVCKSPADPLDKAKEFCIKEQSNPHVNDAGLKGVGTESLVAFVTEQVPENKLNNSPAAISLTVKASLKTTDLSDFQAVSKQSMSKPCACMDKICQCRRWQDMEVYKFSGLQNTLPLPPERRTVTEDHSQPLASRTPSSSPRSCSEQARAYVDDVTIEDLSGYLEYYLYIPKKMSHMAEMMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0F7</accession>
    <name>A0A151P0F7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0F7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO42390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="10618" checksum="ED71B941F17B0EF7" modified="2016-06-08" version="1">MARSTVEAGVVPDKGNKIKLLGGLLKFRVILDSGGCRRKCRSLPSQPPYAEPRSNNLSLVAQVISAGERCQRDLHPSSEILGNRTRITGLVDNGNMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1A7</accession>
    <name>A0A151P1A7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Prosaposin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Pulmonary surfactant-associated protein B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Pulmonary surfactant-associated proteolipid SPL(Phe)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PSAP-1</name>
        <name evidence="22" type="ORF">Y1Q_0022283</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Surface film</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1A7"/>
    <dbReference type="STRING" id="8496.A0A151P1A7"/>
    <dbReference type="eggNOG" id="KOG1340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="69496at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000002">
        <property type="entry name" value="prosaposin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000008">
        <property type="entry name" value="Pulmonary surfactant-associated protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003119">
        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF36">
        <property type="entry name" value="PROSAPOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00162">
        <property type="entry name" value="SAPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51110">
        <property type="entry name" value="SAP_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0305">Gaseous exchange</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0767">Surface film</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586586" description="Prosaposin" evidence="19">
        <location>
            <begin position="24"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="21">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="20">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="20">
        <location>
            <begin position="199"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="20">
        <location>
            <begin position="312"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="20">
        <location>
            <begin position="410"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="21">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="529" mass="59550" checksum="6F32C5AC78C56D13" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2H2</accession>
    <name>A0A151P2H2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0017577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2H2"/>
    <dbReference type="STRING" id="8496.A0A151P2H2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000001">
        <property type="entry name" value="R3H domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF14">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="188"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO43284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="253" mass="28927" checksum="136E9067BDBD89E2" modified="2016-06-08" version="1">MARATEAARKTSGIKATLKVTKSCCFNFCLEECLSKNCIINKTESSEVEEKEEKLSDAKTELQKRGANQNQQKKRSKSGAKGKLVRSLAVCEESSPRLGAEGLHDNQESIQLQLSSFPSLQEEDKSSKDDSEKDREKEKDKNKEKDKTCEKPKIRMLSKDCSQEYTDSTGIDLHEFLINTLKNNPRDRMILLKMEQEIIDFISDNNNHYKKFPQMSSYQRMLVHRVAAYFGMDHNVDQTGKSVIINKTSNTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P682</accession>
    <name>A0A151P682_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">D(1B) dopamine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DRD5</name>
        <name evidence="14" type="ORF">Y1Q_0016775</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000764">
        <property type="protein sequence ID" value="KYO44480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P682"/>
    <dbReference type="STRING" id="8496.A0A151P682"/>
    <dbReference type="GeneID" id="102559848"/>
    <dbReference type="KEGG" id="amj:102559848"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021915at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004952">
        <property type="term" value="F:dopamine neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000045">
        <property type="entry name" value="D(1A) dopamine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000497">
        <property type="entry name" value="Dopamine_D5_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000929">
        <property type="entry name" value="Dopamine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF123">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00566">
        <property type="entry name" value="DOPAMINED1BR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00242">
        <property type="entry name" value="DOPAMINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="53"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO44480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="453" mass="51038" checksum="90AD8E3FE54B4018" modified="2016-06-08" version="1">MDGLYFSREADGLATINDTLSRESWGEEANSELSLRVVTGVLLFLLILSTLLGNTLVCAAVVKFRHLRSKVTNFFVISLAVSDLFVAVLVMPWKAVTEVAGFWPFGGFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTRRVAFVMIGVAWLLSILISFIPVQLQWHKASELLPPQELSFNISQEENCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIFRIAQHQIRRISSLERAVEHAQNCHSSDCSHEASLKNSFRKETKVLKTLSIIMGVFVFCWLPFFVLNCMVPFCDFSRHEPGELPCVTETVFNIFIWFGWANSSLNPIIYAFNADFRKAFATILGCNRLCPSNAVETVNFSNELVSYHHDTTYQKEVVTLSYPHILPHAAMQAEDHEVTFDKVSQISQTSHNNHPGPVLPAVVHVECEVAVSLEKITPFTPSVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6P8</accession>
    <name>A0A151P6P8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC91</name>
        <name evidence="3" type="ORF">Y1Q_0016851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6P8"/>
    <dbReference type="STRING" id="8496.A0A151P6P8"/>
    <dbReference type="eggNOG" id="ENOG502QW5U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090160">
        <property type="term" value="P:Golgi to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034592">
        <property type="entry name" value="CCDC91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35072">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35072:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="473" mass="53705" checksum="A1E2311EEA73D796" modified="2016-06-08" version="1">MPQPRRAKVPTRRMDDDDFGGFEAAETFEGGDGETQTTSPAIPWAAFPTVTEVYVPQNVSSDVLLEHSLPSACLVPSESFILSSDNVVTAVQTGNSILNPAVIKEQVRLSTGSSLDIPIPSLSLPGEKSLVISTISVDDEQRKGSNGSKSCLQQTVASLETKLKVAEEEKCRIKKELEDLMEKHSVLEMSFLKDKEDIFISYQDHYKELQEKHMHELEDMRKAGHEALSIIVEEFKALLQSAVQQQETAIEKQYISAIEKHSHKCEELLNAQHQRLLGMLEIEKEMLAERVEEALMQESQKHKEVLEKCLDEERKRSKEALAAAAKTEKEAMQEAILKAVEEERKNMEKMHAEEREIWQAERTKDKEKIAQAVEEAMQEQRKSSQEVVKAAIMEEQKRSEKAVEEAVKRTREELMEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSTLLKEEPVTAEQKKETDALSKTDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6Y3</accession>
    <name>A0A151P6Y3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6Y3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="102" mass="11861" checksum="198FF9A50073613A" modified="2016-06-08" version="1">MAEMEIPRSLLLLLPGAGRPGWLWQGKHVEEKLEPVARRLQRCKVNTLASSLCDWSQRLVSQGVKYCLRLHAEKDVPVAWQDELKKHKEKSSERIQRSFQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7B7</accession>
    <name>A0A151P7B7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cullin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CUL5</name>
        <name evidence="13" type="ORF">Y1Q_0022994</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000640">
        <property type="protein sequence ID" value="KYO44928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006262528.1">
        <property type="nucleotide sequence ID" value="XM_006262466.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7B7"/>
    <dbReference type="STRING" id="8496.A0A151P7B7"/>
    <dbReference type="GeneID" id="102568223"/>
    <dbReference type="KEGG" id="amj:102568223"/>
    <dbReference type="CTD" id="8065"/>
    <dbReference type="eggNOG" id="KOG2285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P7B7"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000142">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000009">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000014">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000017">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000004">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="12">
        <location>
            <begin position="403"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO44928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="780" mass="90867" checksum="0102376AF173075C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7B9</accession>
    <name>A0A151P7B9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein NPAT isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NPAT-1</name>
        <name evidence="3" type="ORF">Y1Q_0022992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000640">
        <property type="protein sequence ID" value="KYO44924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7B9"/>
    <dbReference type="STRING" id="8496.A0A151P7B9"/>
    <dbReference type="eggNOG" id="ENOG502QYUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031442">
        <property type="entry name" value="NPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052850">
        <property type="entry name" value="NPAT_LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15087">
        <property type="entry name" value="PROTEIN NPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15087:SF14">
        <property type="entry name" value="PROTEIN NPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15712">
        <property type="entry name" value="NPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein NPAT C-terminal" evidence="2">
        <location>
            <begin position="505"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO44924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1179" mass="126867" checksum="B86A70D4CE9DD3B6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7Z8</accession>
    <name>A0A151P7Z8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metastasis suppressor protein 1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MTSS1</name>
        <name evidence="10" type="ORF">Y1Q_0014632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MTSS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059579745.1">
        <property type="nucleotide sequence ID" value="XM_059723762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7Z8"/>
    <dbReference type="STRING" id="8496.A0A151P7Z8"/>
    <dbReference type="GeneID" id="102562453"/>
    <dbReference type="CTD" id="9788"/>
    <dbReference type="eggNOG" id="ENOG502QRG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151P7Z8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034334">
        <property type="term" value="P:adherens junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07643">
        <property type="entry name" value="I-BAR_IMD_MIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22060">
        <property type="entry name" value="WH2_MTSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000010">
        <property type="entry name" value="Metastasis suppressor 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF10">
        <property type="entry name" value="PROTEIN MTSS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="8">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO45162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="788" mass="85353" checksum="8B1A5D3C916F8776" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8T2</accession>
    <name>A0A151P8T2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase VRK1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Vaccinia-related kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">VRK1</name>
        <name evidence="22" type="ORF">Y1Q_0015108</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8T2"/>
    <dbReference type="STRING" id="8496.A0A151P8T2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14122">
        <property type="entry name" value="STKc_VRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000348">
        <property type="entry name" value="serine/threonine-protein kinase VRK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="81"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO45442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="419" mass="48527" checksum="784CF51DE954DB8B" modified="2016-06-08" version="1">MNGPSPRGSGRGRVQVAQAFSVARLKYFEANEFCIQVCKPFYDVKMPYIKKTSGKRAPAKRKLAEEFAPGEVLTDTSKKEWKLGMHIGQGGFGRLYLADVNSSKSVGSDASYVVKVEPSQNGPLFSELKFYMRAAKPEQIQKWTKSHKLKYLGVPRYWGSGLHQKNGNSYRFMVMDRFGRDLQKIYEENSKRFAHKTVLQFGLRILDILEYIHEYEYVHGDIKASNILLNYKNPNQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEYTSIDAHKGVAPSRRGDLEILGYCMIHWLSGHLPWEDNLKDPNYVRDSKIRYRENIADLMEKCFLGENKPDEIAKYMEKVKLLSYEDKPFYQHFREILLQGLKAIGQRDDGILDIGLSENGDLQTKPIQKNLRISRWVKMDVKENEKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9M4</accession>
    <name>A0A151P9M4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0021393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032771">
        <property type="entry name" value="DUF4527"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057884">
        <property type="entry name" value="FN3_RIM-BP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36866">
        <property type="entry name" value="CHROMOSOME 4 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36866:SF1">
        <property type="entry name" value="GENE 1043-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15030">
        <property type="entry name" value="DUF4527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25523">
        <property type="entry name" value="Ig_RIMBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1245"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1379"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="751"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="851"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO45733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1398" mass="159351" checksum="CFD29CFDAF9FF51E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9S7</accession>
    <name>A0A151P9S7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9S7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="13628" checksum="E9B5C34D6A99DA98" modified="2016-06-08" version="1">MPPPSVGTLCMHCLHQEWIQDQTLLLEQLVTVPDDWVMDLQAWQAQGLEQERNWEDHVFQERNLAIEEKHIALLEMIHESQEHQAAMVAPAVKASEEDFWVLDTILALAISQRSDNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PA54</accession>
    <name>A0A151PA54_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0021572</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PA54"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000022">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000023">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF84">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE VD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1045"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1077"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1126"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1160"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1184"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1230"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1014"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="853"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="854"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="962"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="968"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="988"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="991"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="992"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="992"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO45966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1323" mass="148978" checksum="62A08A136C917C93" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAF6</accession>
    <name>A0A151PAF6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAF6"/>
    <dbReference type="STRING" id="8496.A0A151PAF6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF41">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="327" mass="36872" checksum="70B6B6B669656BB7" modified="2016-06-08" version="1">MLYEAEEGDFIGEICLLNNTNCLTSVICKSEVELLVISKEDFDATLANALFKQYHGTCNFLRKLTLFSSWPAEKIDFLVHCSLRRFYRTGTTVVPDSLNSYFLVVVKSGRCLVATQLNQERISAHSSKMHSFSSLHKKIIALSLLEEKKDFAWRLLKRPAGLSQKSYSATHRTNCNQIPRRLRPQTAAVSCYSLRERKSPSDLEQKEPSERDDQMRTVIKKQKVASSAPLFLKTWALEQEGSFGLAETMDKFCGLKFSLISEGADCIFIPQKIFLEKAPDKSKRAALERAETKGGSSLLVAKGERALFEWEGKEDLLTSAPAQKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAX5</accession>
    <name>A0A151PAX5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0021691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PAX5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF43">
        <property type="entry name" value="SI:CH211-212K18.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="703"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1734"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1976"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1740"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1976"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1996"/>
            <end position="2005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO46130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2005" mass="227595" checksum="9731E021C2E25D77" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBF4</accession>
    <name>A0A151PBF4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macroglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBF4"/>
    <dbReference type="STRING" id="8496.A0A151PBF4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF165">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macroglobulin" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="89" mass="9892" checksum="C502A80728D2F176" modified="2016-06-08" version="1">MPSSSFAVLPKFEVLVKLPKVITINNEELQVSVCGLYIYGKPVLGTVNVHVCQKFSSPRSCCYGERANAVWEEFTRLMSAGIKIQGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCR9</accession>
    <name>A0A151PCR9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nebulette</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NEBL</name>
        <name evidence="7" type="ORF">Y1Q_0014390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCR9"/>
    <dbReference type="STRING" id="8496.A0A151PCR9"/>
    <dbReference type="eggNOG" id="KOG1702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09447">
        <property type="entry name" value="LIM_LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000087">
        <property type="entry name" value="LIM zinc-binding domain-containing Nebulette"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF3">
        <property type="entry name" value="NEBULETTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO46780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="14812" checksum="CC7DE9F9C200258E" modified="2016-06-08" version="1">MNPQCARCGKVVYPTEKVNCLDKYWHKGCFHCEVCKMALNMNNYKGYEKKPYCNAHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVCDYILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE21</accession>
    <name>A0A151PE21_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fanconi anemia group M protein isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FANCM-1</name>
        <name evidence="7" type="ORF">Y1Q_0019955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000474">
        <property type="protein sequence ID" value="KYO47240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PE21"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20077">
        <property type="entry name" value="XPF_nuclease_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031879">
        <property type="entry name" value="FANCM-MHF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047418">
        <property type="entry name" value="XPF_nuclease_FANCM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16783">
        <property type="entry name" value="FANCM-MHF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="105"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="948"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1350"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1292"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1384"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO47240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1655" mass="186308" checksum="3F5B0D8CD7DFA4B6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PF85</accession>
    <name>A0A151PF85_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">N(6)-adenosine-methyltransferase non-catalytic subunit METTL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 6">Methyltransferase-like protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">METTL14</name>
        <name evidence="8" type="ORF">Y1Q_0001230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer; heterodimerizes with mettl3 to form an antiparallel heterodimer that constitutes an active methyltransferase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PF85"/>
    <dbReference type="STRING" id="8496.A0A151PF85"/>
    <dbReference type="eggNOG" id="KOG2097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140640">
        <property type="term" value="F:catalytic activity, acting on a nucleic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO47435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="428" mass="49711" checksum="8358031EC1426E93" modified="2016-06-08" version="1">MAMNIRLQEIRERQKLRRQLLAQQLGAENADSIGAVLNSKDDQREIAETRETCRASYDTSAPGLKRKYPDEGEADEEEIEDYKDEVELQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADLEAFDIRELKSKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIEEIAAPRSFVFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVRRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNFNAETYASYFTAPNSHLTGCTEEIERLRPKSPPPKTNSHKFLPRSYATSVKMRRFAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PG94</accession>
    <name>A0A151PG94_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Riboflavin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RBP</name>
        <name evidence="5" type="ORF">Y1Q_0003610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folate receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000266">
        <property type="protein sequence ID" value="KYO48013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PG94"/>
    <dbReference type="STRING" id="8496.A0A151PG94"/>
    <dbReference type="eggNOG" id="ENOG502RYYP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151PG94"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902444">
        <property type="term" value="F:riboflavin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004269">
        <property type="entry name" value="Folate_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517">
        <property type="entry name" value="FOLATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517:SF19">
        <property type="entry name" value="RETBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Folate receptor-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO48013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="206" mass="23750" checksum="7E7E0F9D9BBAFCD1" modified="2016-06-08" version="1">MHECTLYSKSSCCDADFTAQLDHSPVIKVNNSYWNRCGNLSKSCEDYTKKIECFYRCSPYAAHWINPNYTAAIEFVPLCQNFCDDWYEACKEDLTCVRNWLTDWEWDDNGVNHCKSDCSPYSEVFANGTELCQTLWGHSFKVSESSCLCLQMNEKDDVAIKYILSESSEESSSVSSSEERACRKKVLRSEHLNGQEWPETIIIEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGB3</accession>
    <name>A0A151PGB3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">XKR8</name>
        <name evidence="10" type="ORF">Y1Q_0001960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGB3"/>
    <dbReference type="STRING" id="8496.A0A151PGB3"/>
    <dbReference type="GeneID" id="102574896"/>
    <dbReference type="KEGG" id="amj:102574896"/>
    <dbReference type="CTD" id="55113"/>
    <dbReference type="eggNOG" id="KOG4790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6136301at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF8">
        <property type="entry name" value="XK-RELATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO48157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="407" mass="46453" checksum="EE99E311AEA3018C" modified="2016-06-08" version="1">MARPDPRPARLRRRDLLLMVLGTAAFLADLGTDLWMACSYVRAGHRLWGVLVLALLALSSLATQLFSWAWHHTDPPVLRERLAPGACLALLHLLQLGYLSRCVHAVKVGWQVCKPGVTEEEKAYVLFLSHDISMLRLFETFLETAPQLTFVLYVILQTNEIELFQGFGICTAFLCVAWALLDYHQSLRCFLREKYKLDLLSSFVYFTWNFFLTCPRILSVALFATLFPHFIALHVLSVWAVMVLWVWLQKTNFMDSPGLEWFYRATVGMILYFCWFNVAKGRTIYRSIIYHVFILVDCALLVASWAWYNSPLDEHLYPCYVLPAALVCYFLGLLLKGIYYKYFHPTMQTQHHDEVDAAGSVTAAEFRAGRAPVIVNKRMYQLVQSHFAASSLAGQSLANGVEADALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGG7</accession>
    <name>A0A151PGG7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Luteinizing hormone, beta polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LHB</name>
        <name evidence="9" type="ORF">Y1Q_0024420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycoprotein hormones subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000245">
        <property type="protein sequence ID" value="KYO48196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGG7"/>
    <dbReference type="STRING" id="8496.A0A151PGG7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00069">
        <property type="entry name" value="GHB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000007">
        <property type="entry name" value="Luteinizing hormone beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001545">
        <property type="entry name" value="Gonadotropin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018245">
        <property type="entry name" value="Gonadotropin_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515:SF11">
        <property type="entry name" value="LUTROPIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00068">
        <property type="entry name" value="GHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00689">
        <property type="entry name" value="GLYCO_HORMONE_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0372">Hormone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glycoprotein hormone subunit beta" evidence="8">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO48196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9491" checksum="FB3320464D8A5803" modified="2016-06-08" version="1">MCMSVGYCQTKEPVYKSALSPVAQHVCTYREVRYESLVLPACPPGIDPTFTYPVALSCHCSLCPMDSSDCTVQSIGPDFCSARRGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PH70</accession>
    <name>A0A151PH70_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0017124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000209">
        <property type="protein sequence ID" value="KYO48358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PH70"/>
    <dbReference type="STRING" id="8496.A0A151PH70"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO48358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="166" mass="18265" checksum="0DBA5D9F04657BED" modified="2016-06-08" version="1">MLLLHGFPQNWYCWRHQLQEFRKRFRVVALDMRGYNASGAPSGEKSYEIPLLVEDVREVIEMLGTKDKQGSVKAIVVGHDCGGVLAWVFTAQHPNLVEKLILMNTTHPSALIGDALSPRLLSIPPPVPRPSNNRAEAEAASAPPSSRSPSGWWGLVASQHKGSPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHQ9</accession>
    <name>A0A151PHQ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metaxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MTX3-1</name>
        <name evidence="11" type="ORF">Y1Q_0003962</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHQ9"/>
    <dbReference type="STRING" id="8496.A0A151PHQ9"/>
    <dbReference type="GeneID" id="102572308"/>
    <dbReference type="KEGG" id="amj:102572308"/>
    <dbReference type="CTD" id="345778"/>
    <dbReference type="eggNOG" id="KOG3028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PHQ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03212">
        <property type="entry name" value="GST_C_Metaxin1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017410">
        <property type="entry name" value="Metaxin1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF30">
        <property type="entry name" value="METAXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038150">
        <property type="entry name" value="Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="10">
        <location>
            <begin position="173"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO48533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="313" mass="35145" checksum="D00E0DFFA32FB571" modified="2016-06-08" version="1">MAAPMELSCWGGGWGLPSVHTESLIVMAYARFSGAPLRVSAVDHSWSAPQGDVPVLISEDAVIAQPAKILNYLRKQKYNADYELSAKQGADTLAYIALLEEKLLPAILHTFWVEAENYCSVTKPWYASRIPFPLRLYLPGKMSRKALNRILLMRGEPPLYRLNDVEAQIYRDAKECLNLLSNRLGTSQFFFGNTPTTLDAFVFGFLAPLYKVHFPKVQLQEHLKQLHNLCRFCDDILSGYFRLSVTGFSPAGQDTVDANLQKLTQLVNKESNLIEKMDDNLRKSPQHPPRKLTTLKLSAAGEESSLLTRLSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHT6</accession>
    <name>A0A151PHT6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHT6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="8027" checksum="AD7C1C5949F53EB1" modified="2016-06-08" version="1">MPRMTKEDDPKTYIEAFERTAIQTGLDRDWDSILIATSSDNSSCFINLHLKRGQLSTYILMMAPDWLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYD5</accession>
    <name>A0A151LYD5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Keratin, type II cytoskeletal 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KRT5</name>
        <name evidence="7" type="ORF">Y1Q_0017714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007029">
        <property type="protein sequence ID" value="KYO17269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A151LYD5"/>
    <dbReference type="STRING" id="8496.A0A151LYD5"/>
    <dbReference type="eggNOG" id="ENOG502QWIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF39">
        <property type="entry name" value="KERATIN, TYPE II CYTOSKELETAL 6A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="168"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="540"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="908"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="379"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="756"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="912"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1328"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1466"/>
            <end position="1493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO17269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1520" mass="171374" checksum="A1BE02094301D7C4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYE2</accession>
    <name>A0A151LYE2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aquaporin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADH water channel</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Aquaporin-CD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Collecting duct water channel protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">WCH-CD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Water channel protein for renal collecting duct</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">AQP2</name>
        <name evidence="26" type="ORF">Y1Q_0017709</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 23">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007029">
        <property type="protein sequence ID" value="KYO17263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275751.1">
        <property type="nucleotide sequence ID" value="XM_006275689.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYE2"/>
    <dbReference type="STRING" id="8496.A0A151LYE2"/>
    <dbReference type="GeneID" id="102565236"/>
    <dbReference type="KEGG" id="amj:102565236"/>
    <dbReference type="CTD" id="359"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="PhylomeDB" id="A0A151LYE2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000003">
        <property type="entry name" value="Lens fiber major intrinsic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF45">
        <property type="entry name" value="AQUAPORIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02014">
        <property type="entry name" value="AQUAPORIN2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 23" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO17263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="274" mass="29820" checksum="CF006EDA1707D019" modified="2016-06-08" version="1">MMWELRSVAFTRAVFAEFIATLLFIFFGLGSALSWPLSLPTILQISLAFGLAIATLVQTLGHVSGAHINPAVTVACLVGSHISFLRAVFYVVAQILGGVAGAAILHEITPPAIRGNLAINKLYNETTTGQAVTMELFLTFQLVLCIFASTDDRRSDNVGSPALSIGLSVALGHLLGINYTGCSMNPARSFAPAVIVGDFTDHWVFWLGPLVGALAASLIYNYLLFPHTKTLSERLAIFKGFEPEEDWEEREARRRQSVELHSPQTMPRGMTEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYW1</accession>
    <name>A0A151LYW1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centrosomal protein of</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CEP83</name>
        <name evidence="7" type="ORF">Y1Q_0020052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267523.1">
        <property type="nucleotide sequence ID" value="XM_006267461.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019336421.1">
        <property type="nucleotide sequence ID" value="XM_019480876.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYW1"/>
    <dbReference type="STRING" id="8496.A0A151LYW1"/>
    <dbReference type="GeneID" id="102575998"/>
    <dbReference type="KEGG" id="amj:102575998"/>
    <dbReference type="CTD" id="51134"/>
    <dbReference type="eggNOG" id="ENOG502QWE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="PhylomeDB" id="A0A151LYW1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052116">
        <property type="entry name" value="Centro_Cilium_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 83 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="679"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="437"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="564"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO17436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="717" mass="84561" checksum="25C30722E4841A27" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZ18</accession>
    <name>A0A151LZ18_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0020085</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 14">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZ18"/>
    <dbReference type="STRING" id="8496.A0A151LZ18"/>
    <dbReference type="KEGG" id="amj:102564753"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733721at2759"/>
    <dbReference type="PhylomeDB" id="A0A151LZ18"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13 14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="16">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO17482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="13950" checksum="608F149A0C87CB60" modified="2016-06-08" version="1">MPEPAKSAPVPKKGSKKAVTKTQKKGDKKRKKSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1Y3</accession>
    <name>A0A151M1Y3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho-related GTP-binding protein RhoJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RHOJ</name>
        <name evidence="10" type="ORF">Y1Q_0014791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006264304.1">
        <property type="nucleotide sequence ID" value="XM_006264242.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1Y3"/>
    <dbReference type="STRING" id="8496.A0A151M1Y3"/>
    <dbReference type="GeneID" id="102560765"/>
    <dbReference type="KEGG" id="amj:102560765"/>
    <dbReference type="CTD" id="57381"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M1Y3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000438">
        <property type="entry name" value="Rho-related GTP-binding protein RhoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO18519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="214" mass="24054" checksum="95D9BC2F8B29EE3F" modified="2016-06-08" version="1">MNCKEEDENCTDGSSDNRKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVTVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPHTDVFLICFSVVNPASYHNVQEEWVPELKDCMPDVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKEIGAQCYLECSALTQKGLKTVFDEAILTIFNPKKKKKHCMKCHGCCTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2N0</accession>
    <name>A0A151M2N0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centriole, cilia and spindle-associated protein isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCSAP-1</name>
        <name evidence="2" type="ORF">Y1Q_0009212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2N0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029774">
        <property type="entry name" value="CSAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31022">
        <property type="entry name" value="CENTRIOLE, CILIA AND SPINDLE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31022:SF4">
        <property type="entry name" value="CENTRIOLE, CILIA AND SPINDLE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15748">
        <property type="entry name" value="CCSAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="183" mass="21242" checksum="6F0F9D33A227D5D4" modified="2016-06-08" version="1">MVPARRVKTEYMKRYKEPKWESCGACYLELLRYRLSQKKTEGENQEKAAEQAAVKETDKSTSRAGQRPSRSALSSRDDRKSTKSPQRTEAPKENKHPFALYGWGEKQTDTGSQKTHNVCASASVREIHESALRAKNRRQVEKRKLSQRRVRSADAEKTWRTKSSPPDNPWMTEYMRCYSARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M362</accession>
    <name>A0A151M362_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M362"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584715" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="7919" checksum="0A00D7A188E2DE08" modified="2016-06-08" version="1">MYSFTMEWLLSLSLSFAAGGGEGKQQPQPEAGLFSGALLLKSRRGDNNKLACLPPCTTPGICGGGAIWDSMEVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3N2</accession>
    <name>A0A151M3N2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006740">
        <property type="protein sequence ID" value="KYO19122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3N2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7248" checksum="82E5889C789B04EC" modified="2016-06-08" version="1">MTILDFLNSRLAAFQPAKGCLEQLEAAGACASACVHTHGRYAARKGHGSSSSSWMQPGIERGKSRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3Z6</accession>
    <name>A0A151M3Z6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alkaline ceramidase</fullName>
            <ecNumber evidence="15">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ACER3</name>
        <name evidence="16" type="ORF">Y1Q_0001125</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:41299"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:41300"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an N-acylsphinganine + H2O = sphinganine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:33551"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33552"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03006672">
        <property type="protein sequence ID" value="KYO19216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014456990.1">
        <property type="nucleotide sequence ID" value="XM_014601504.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3Z6"/>
    <dbReference type="STRING" id="8496.A0A151M3Z6"/>
    <dbReference type="GeneID" id="102568537"/>
    <dbReference type="KEGG" id="amj:102568537"/>
    <dbReference type="CTD" id="55331"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071602">
        <property type="term" value="P:phytosphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO19216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="267" mass="31123" checksum="F6DFE28D5FDCB010" modified="2016-06-08" version="1">MAPAADRAGYWGPPTSTLEWCEENYAVSHYIAEFWNTVSNLIFILPPLYGAIQSYKDGLEKRYLAAYLSLTAVGLGSWCFHMTLKYEMQLLDELPMIYTCCVFVYCLYECFKYKNTVNYPLLCILIGYSFVVSIIYLKLKEPIFHQIMYGTLVSVVVMRSVYIVLWVYPWLRGLGYTSLTVFLMGFFLWNVDNIFCDKLRAVRDKMPPVVGAVTQFHAWWHILTGLGSYLHILLSLYTRTLFLKYRPKVKFIFGIWPVLLVEPPKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4I2</accession>
    <name>A0A151M4I2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0003566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
        <property type="protein sequence ID" value="KYO19435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4I2"/>
    <dbReference type="STRING" id="8496.A0A151M4I2"/>
    <dbReference type="KEGG" id="amj:109281077"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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        <property type="match status" value="12"/>
    </dbReference>
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        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CARD" evidence="4">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO19435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="754" mass="83136" checksum="EA6A986444E25387" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5K0</accession>
    <name>A0A151M5K0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neurexin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0021034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006558">
        <property type="protein sequence ID" value="KYO19761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5K0"/>
    <dbReference type="STRING" id="8496.A0A151M5K0"/>
    <dbReference type="eggNOG" id="KOG3514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027789">
        <property type="entry name" value="Syndecan/Neurexin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF57">
        <property type="entry name" value="NEUREXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01034">
        <property type="entry name" value="Syndecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="11">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO19761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="552" mass="60442" checksum="8DA4031FDC0B9519" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5S2</accession>
    <name>A0A151M5S2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-binding cassette sub-family F member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ABCF1</name>
        <name evidence="14" type="ORF">Y1Q_0006828</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006526">
        <property type="protein sequence ID" value="KYO19864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M5S2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000471">
        <property type="entry name" value="ATP-binding cassette, sub-family F (GCN20), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000472">
        <property type="entry name" value="ATP-binding cassette, sub-family F (GCN20), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000355">
        <property type="entry name" value="ribo_prot_ABC_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="364"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="707"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="641"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO19864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="927" mass="105051" checksum="6569A5FB921EFE8B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5V5</accession>
    <name>A0A151M5V5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0006852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006526">
        <property type="protein sequence ID" value="KYO19894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5V5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="327" mass="32448" checksum="986C7265CD84421E" modified="2016-06-08" version="1">MKWCQVCGVFAGVEIILAATEVVPTLVVVFVSVDILGTAVVVALGMEVLAASVVVVAVVELGSSVLETAVAAVEVVPTAVMEANVLDMVVAAIVATVSVEVIVAAADVMAALVLVVVGMEVVAMLVVLGVEVLLASVVIGALVEVKAVVLEMAIATLEVVFLGVVEATGVDVLGAAVAVSVAITIIGVSAVVTTGPDVALPVLRVAAGMEVAPAFIMVAARLDVEAGSVVVAPSVEVEAGSDVLAASIKVVAISVLVDSGAEMLIASFVVDSDMNLGVAVVEMFVATLKSVSSSVVRATAMGMVAPTVTVAVGVQVTEAIVMIVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M618</accession>
    <name>A0A151M618_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integral membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ITM2C</name>
        <name evidence="18" type="ORF">Y1Q_0021897</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with BACE1. Interacts with APP. Interacts with STMN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Lysosome membrane</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ITM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006480">
        <property type="protein sequence ID" value="KYO19963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274228.2">
        <property type="nucleotide sequence ID" value="XM_006274166.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M618"/>
    <dbReference type="STRING" id="8496.A0A151M618"/>
    <dbReference type="GeneID" id="102561797"/>
    <dbReference type="KEGG" id="amj:102561797"/>
    <dbReference type="CTD" id="81618"/>
    <dbReference type="eggNOG" id="KOG4681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9982095at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042985">
        <property type="term" value="P:negative regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040145">
        <property type="entry name" value="ITM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962">
        <property type="entry name" value="INTEGRAL TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="17">
        <location>
            <begin position="132"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO19963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="263" mass="30266" checksum="1FF2EE262FBFA523" modified="2016-06-08" version="1">MVKISFQQPAAALKPDKAAAGDGANAEILLPRRGEEQPPPMQTRRSSLSGVCYLTIGLIVLLLGLVFASMYVYRYFFITQFPQLPRESVFHCGVLYEDSLYSPFKGQLELHEDVKIYIEENYEQINVPVPQFGGSDPADIIHDFQRGLTAYHDIALDKCYVIELNTTIVMPPRNLWELLVNVKKGTYLPQTYIIQEEMIVTEHVSDMEQLGSFIYRLCSGKETYRLKRRTARRRINRREAGNCNHIRHFENTFVVETVICKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M679</accession>
    <name>A0A151M679_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="5">EF-Ts</shortName>
            <shortName evidence="5">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TSFM</name>
        <name evidence="8" type="ORF">Y1Q_0009485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006443">
        <property type="protein sequence ID" value="KYO20008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M679"/>
    <dbReference type="STRING" id="8496.A0A151M679"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.20:FF:000007">
        <property type="entry name" value="Elongation factor Ts, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.20:FF:000008">
        <property type="entry name" value="Elongation factor Ts, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25025">
        <property type="entry name" value="EF-Ts_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="7">
        <location>
            <begin position="290"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO20008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="521" mass="56870" checksum="8903BDCBC6482A92" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6R8</accession>
    <name>A0A151M6R8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neuron-specific protein family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HMP19</name>
        <name evidence="10" type="ORF">Y1Q_0010759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6R8"/>
    <dbReference type="STRING" id="8496.A0A151M6R8"/>
    <dbReference type="GeneID" id="102577232"/>
    <dbReference type="KEGG" id="amj:102577232"/>
    <dbReference type="CTD" id="51617"/>
    <dbReference type="eggNOG" id="ENOG502QRFC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8924576at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009431">
        <property type="entry name" value="NSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28546:SF2">
        <property type="entry name" value="NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28546">
        <property type="entry name" value="NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06387">
        <property type="entry name" value="Calcyon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002383">
        <property type="entry name" value="Calcyon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO20194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="183" mass="20377" checksum="0B56494D81029664" modified="2016-06-08" version="1">MVKLGSNLSDKNSKQPSSEDGFQTVPLITPLEVNHLQFPAPEKVIVKTRTEYQPDQKNKGKLRVPKIAEFTVSFTDGVTERLKVTILISLALAFLACIVFLVVYKAFTYDHSCPDGFVYKHKRCIPASLDAYYSAQDSNSRGRFYTVISHYSMAKQTSSRSVSPWLSSGSVNHEAKAAKTEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7Y2</accession>
    <name>A0A151M7Y2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="23">A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ADAMTS17</name>
        <name evidence="23" type="ORF">Y1Q_0012520</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M7Y2"/>
    <dbReference type="eggNOG" id="KOG3538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009626">
        <property type="entry name" value="MINAR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF197">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06789">
        <property type="entry name" value="MINAR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 17 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 23" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 16 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584850" evidence="21">
        <location>
            <begin position="26"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1287"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="22">
        <location>
            <begin position="231"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="50"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="15 18">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="345"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17 18">
        <location>
            <begin position="364"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="549"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO20626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1309" mass="145935" checksum="CAEDA4B6CBC33D3F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M873</accession>
    <name>A0A151M873_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Patched-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PTCH1</name>
        <name evidence="11" type="ORF">Y1Q_0012579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M873"/>
    <dbReference type="eggNOG" id="KOG1935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097108">
        <property type="term" value="F:hedgehog family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008158">
        <property type="term" value="F:hedgehog receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000003">
        <property type="entry name" value="protein patched homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000007">
        <property type="entry name" value="Protein patched homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004766">
        <property type="entry name" value="TM_rcpt_patched"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00918">
        <property type="entry name" value="2A060602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022">
        <property type="entry name" value="PROTEIN PATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46022:SF5">
        <property type="entry name" value="PROTEIN PATCHED HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="790"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1124"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1155"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="440"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1188"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1270"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1385"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1219"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1281"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1479" mass="165012" checksum="ECE6A82100C503FF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8A4</accession>
    <name>A0A151M8A4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-alpha-acetyltransferase 35, NatC auxiliary subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein MAK10 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAA35</name>
        <name evidence="9" type="ORF">Y1Q_0012598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8A4"/>
    <dbReference type="STRING" id="8496.A0A151M8A4"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151M8A4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like N-terminal" evidence="7">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="8">
        <location>
            <begin position="317"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO20721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="704" mass="81263" checksum="193B8B8A3880B2A2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9D0</accession>
    <name>A0A151M9D0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 6 superfamily member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TM6SF1-1</name>
        <name evidence="13" type="ORF">Y1Q_0001422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May function as sterol isomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TM6SF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9D0"/>
    <dbReference type="STRING" id="8496.A0A151M9D0"/>
    <dbReference type="eggNOG" id="ENOG502QRB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21106">
        <property type="entry name" value="TM6SF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047195">
        <property type="entry name" value="TM6SF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059044">
        <property type="entry name" value="TM_Tm6sf1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568:SF10">
        <property type="entry name" value="TRANSMEMBRANE 6 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14568">
        <property type="entry name" value="TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26083">
        <property type="entry name" value="TM_Tm6sf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="12">
        <location>
            <begin position="60"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="12">
        <location>
            <begin position="216"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO21127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="359" mass="40074" checksum="BF2D33ADA3845AF6" modified="2016-06-08" version="1">MSASAATGVFVLSLTAIPVTYLFNCLAATSGSWAIVAVGSLVLIFVAVVARILVKRKPPKDPLFYVYAVFSFTSVVNLIIGLEQDGIIDGFMTYYLKEGEPYLNTAHGHVICYWDGSAHYLMYLLMVAAIAWEESYRTIGLYWLGSIVMSIIVFMPGNIVGKYGTRLCPAFFLNIPYICLPIWAGFRIYSQPSVTHNTPVKVVQEVQKKGLLKRPIDLMLAIYLIPATGFCIFRGMIALDCPAELCRSYIQLHEPYIKDPAAYPKLQMLAYMFYSVPYYVITLYGLVVPGCSWMPDVTLIHAGGLAQAQFSHIGASLHARTPYVYRVPEEAKLFFLALNIMYGILPQLLAYSKLVNYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAD1</accession>
    <name>A0A151MAD1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAT1-like protein 2 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PATL2-1</name>
        <name evidence="9" type="ORF">Y1Q_0001679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAD1"/>
    <dbReference type="STRING" id="8496.A0A151MAD1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF3">
        <property type="entry name" value="PROTEIN PAT1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="511"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO21483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="800" mass="90807" checksum="53535B3CDB9959A3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBR6</accession>
    <name>A0A151MBR6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Doublecortin domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DCDC1</name>
        <name evidence="2" type="ORF">Y1Q_0000606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBR6"/>
    <dbReference type="STRING" id="8496.A0A151MBR6"/>
    <dbReference type="eggNOG" id="ENOG502RKGR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043188">
        <property type="entry name" value="DCDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056415">
        <property type="entry name" value="DCX2_DCDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302:SF3">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24478">
        <property type="entry name" value="DCX2_DCDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCDC1 second doublecortin-like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="152" mass="17105" checksum="E257D7166EED44EF" modified="2016-06-08" version="1">MTLVSQDHLSLMKKIIWTVNGLVFPAGVKRKKTKPVLSYGMKRLVEKSSLRILAFKNCTGQDGYEIIAEQNQIEKFLDECTMKMNLTSPAKYLYNIHGEKIENIINDTAQDIFLPSFHFGHFGPGSLGAAWGDPERKTPRLPISFLPSLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC28</accession>
    <name>A0A151MC28_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MC28"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="10710" checksum="D3D241A9196ED4FB" modified="2016-06-08" version="1">MQGSQTSGDARSLYAAIEKNLPECNQDLTWVVGATTDWLKSPEAETKGKGSERVGASHRDNLMLRKDLEEQGKAAGSWFNLPHYSLKISNSYCALHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDM0</accession>
    <name>A0A151MDM0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell surface glycoprotein CD200 receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CD200R1-2</name>
        <name evidence="12" type="ORF">Y1Q_0003144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD200R family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDM0"/>
    <dbReference type="eggNOG" id="ENOG502S9IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150077">
        <property type="term" value="P:regulation of neuroinflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040012">
        <property type="entry name" value="CD200R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21462:SF2">
        <property type="entry name" value="CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21462">
        <property type="entry name" value="CELL SURFACE GLYCOPROTEIN OX2 RECEPTOR PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585050" evidence="10">
        <location>
            <begin position="19"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO22624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="295" mass="32678" checksum="250459CE7ACE7294" modified="2016-06-08" version="1">MWLVLAHLLFFLIGQVQGSVSNVFAVTGTRAVLRCPYISVAPMVLAVWNISAKNGTACLLAYRADTNETKSVNCSERMTWESRPDYGPSLQIHPVKLADEGTYMCEVVNSDGSFYETYALTVLVPPEVTLTYESSEIALCRASAGKPAALISWVPMNGHSIENKVHHPNGTVTTVSRMYWNNSTTINMSCLISHPTMNRTLSIDLSPKSPIFQYVMIVAFSCVAVGVLGGVILYWALKYRASQLSGSAHVPTVVNKTRNDIRLQSRTQKINTVYSSIVSDGIYENYRVQNTYKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDR0</accession>
    <name>A0A151MDR0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0003151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDR0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="89" mass="9850" checksum="D321FABCAFDAF362" modified="2016-06-08" version="1">MEQLDNEDHVAHHTLLQRQAEAQEMQIQERHVVVEEEQCDVAAASDEDNWCIIVMVLALVVSVTMPSILALVPADSWQPATGPPQAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ME78</accession>
    <name>A0A151ME78_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ME78"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="107" mass="11948" checksum="5EF7CF0AABEAFF42" modified="2016-06-08" version="1">MSTVCDRGPSLQVKPFPRLALTRTITHLLLLDIASAPQSLLSYLPAPHPGTNPSWPCPHVQPCQSPGRTSLRTPEFPVFCIVLLLLLWSDCRTYKGRERPKLLKFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGP2</accession>
    <name>A0A151MGP2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding region-containing protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNA-binding motif protein 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RNPC3</name>
        <name evidence="13" type="ORF">Y1Q_0010112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006198">
        <property type="protein sequence ID" value="KYO23550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014459579.1">
        <property type="nucleotide sequence ID" value="XM_014604093.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019356447.1">
        <property type="nucleotide sequence ID" value="XM_019500902.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGP2"/>
    <dbReference type="STRING" id="8496.A0A151MGP2"/>
    <dbReference type="GeneID" id="102573584"/>
    <dbReference type="KEGG" id="amj:102573584"/>
    <dbReference type="CTD" id="55599"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MGP2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12238">
        <property type="entry name" value="RRM1_RBM40_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12239">
        <property type="entry name" value="RRM2_RBM40_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000289">
        <property type="entry name" value="RNA-binding protein 40 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000207">
        <property type="entry name" value="RNA-binding region (RNP1, RRM)-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034147">
        <property type="entry name" value="RBM40_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="415"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO23550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="512" mass="57545" checksum="4FE9BCCD8F6C69C1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJJ3</accession>
    <name>A0A151MJJ3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PPIL6</name>
        <name evidence="5" type="ORF">Y1Q_0017801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03006032">
        <property type="protein sequence ID" value="KYO24711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261637.1">
        <property type="nucleotide sequence ID" value="XM_006261575.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJJ3"/>
    <dbReference type="STRING" id="8496.A0A151MJJ3"/>
    <dbReference type="GeneID" id="102572463"/>
    <dbReference type="KEGG" id="amj:102572463"/>
    <dbReference type="CTD" id="285755"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408413at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MJJ3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000024">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00058445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO24711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="294" mass="33327" checksum="0726094BC1C6A2EE" modified="2016-06-08" version="1">MGSAQLQQLEVVGHLKESAFQVAKCAAEALRLNFPTKIAEPVLLPLQQVAWHEYLQEKKKELRGEIWEYPSRVMCFVDGQLLGNEKKLLEWAFEKWNYQDFKPEALYQAITEDFCKKYMKNTQHVFVYLDAAIQEQPLGTLLFELYSDACPKTCENFRALCTGEAGISRSGLQLTYKESIFHRIVKNGWIQGGDIAGGRGDDGESIFGPTFEDENFSIPHNKRGVLGMANKGRHSNGSQFYITLQPAPYLDRKYVAFGQLIEGTDVLQKLEDLPTCNERPVVECKIISCGVFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKJ8</accession>
    <name>A0A151MKJ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO25054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKJ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8917" checksum="073FABB209536657" modified="2016-06-08" version="1">MYEGHVSRAKGETVIKDLERRERTRSPSLLLKDQAKTEGFEKEGSNLSQNQHYRGFNTQKDIWKNQVFNSSCLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ML87</accession>
    <name>A0A151ML87_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005917">
        <property type="protein sequence ID" value="KYO25213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ML87"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10784" checksum="4853DEAA9EE354B3" modified="2016-06-08" version="1">MPKMTWEDGPEAYIDAFEWHAIMTGLDKGYWASQLRALVVGKAQASYRALSWDEAHDYDRVKTTILYRLEINPEHYRRLFRAKKVPEKKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLU3</accession>
    <name>A0A151MLU3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 2 (Facilitated glucose transporter), member 15a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC2A15A</name>
        <name evidence="8" type="ORF">Y1Q_0015223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005799">
        <property type="protein sequence ID" value="KYO25409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLU3"/>
    <dbReference type="STRING" id="8496.A0A151MLU3"/>
    <dbReference type="eggNOG" id="KOG0569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070837">
        <property type="term" value="P:dehydroascorbic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17432">
        <property type="entry name" value="MFS_GLUT_Class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000029">
        <property type="entry name" value="solute carrier family 2, facilitated glucose transporter member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF25">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO25409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="519" mass="56149" checksum="881566DDFC8C7640" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMG4</accession>
    <name>A0A151MMG4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Stathmin isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">STMN1</name>
        <name evidence="10" type="ORF">Y1Q_0023565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the stathmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMG4"/>
    <dbReference type="STRING" id="8496.A0A151MMG4"/>
    <dbReference type="eggNOG" id="KOG1280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030514">
        <property type="entry name" value="Stathmin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF5">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00563">
        <property type="entry name" value="STATHMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01041">
        <property type="entry name" value="STATHMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585314" evidence="9">
        <location>
            <begin position="51"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO25737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="228" mass="25385" checksum="58B608451FB6A144" modified="2016-06-08" version="1">MPSAALGRGLTPPSPPAERHVPPRSANGGGAGRVTCLCLALLCAAGRAGAESCRRCGRSSWRSSWLEISRSRLVVSTVSDMATSDIQVKELEKRASGQAFELILSPRSKEAVPEFPLSPPKKKDVSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKEGKDPGEAETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQD6</accession>
    <name>A0A151MQD6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sorcin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SRI</name>
        <name evidence="9" type="ORF">Y1Q_0019114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261376.1">
        <property type="nucleotide sequence ID" value="XM_006261314.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQD6"/>
    <dbReference type="STRING" id="8496.A0A151MQD6"/>
    <dbReference type="GeneID" id="102569373"/>
    <dbReference type="KEGG" id="amj:102569373"/>
    <dbReference type="CTD" id="6717"/>
    <dbReference type="eggNOG" id="KOG0037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MQD6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16187">
        <property type="entry name" value="EFh_PEF_sorcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000087">
        <property type="entry name" value="Sorcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735">
        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735:SF7">
        <property type="entry name" value="SORCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO26629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="194" mass="21541" checksum="A69C82D0AA12F911" modified="2016-06-08" version="1">MAYPGQPGYYQGGYGGAPGGPAFPGQAQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMISMLDRDMSGTMGFNEFKELWAVLNGWRQHFMGFDNDRSGSVDRQELEKALTNMGFRLSPQAVAAIAKRYSTHGKITFDDYIACCVKLRALTESFRRRDAAQQGFVNFQYDDFIQCVMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQK9</accession>
    <name>A0A151MQK9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromobox protein-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CBX3</name>
        <name evidence="5" type="ORF">Y1Q_0019272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQK9"/>
    <dbReference type="STRING" id="8496.A0A151MQK9"/>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd18652">
        <property type="entry name" value="CD_HP1gamma_Cbx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000007">
        <property type="entry name" value="Chromobox protein homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038033">
        <property type="entry name" value="CBX3_chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO26827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="173" mass="19396" checksum="60CFAFE4C4DF7E05" modified="2016-06-08" version="1">MASNKTTLHKMGKKQNGKGKKVEEAEPEEFVVEKVLDRRVVNGKVEYYLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKTDGAKRKSLSDSESDDSKSKKKRDSVDKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANVKRAFDTTTSSTLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRL9</accession>
    <name>A0A151MRL9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytosolic carboxypeptidase-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0016256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005434">
        <property type="protein sequence ID" value="KYO27050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRL9"/>
    <dbReference type="STRING" id="8496.A0A151MRL9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3120:FF:000002">
        <property type="entry name" value="cytosolic carboxypeptidase-like protein 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF12">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic carboxypeptidase N-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO27050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="200" mass="22144" checksum="E128304FA8F0E49B" modified="2016-06-08" version="1">MEARCGGLLFSSRFDSGNLAHVEKVEAPEGDGDTGASGSGSVSVSGLPPFGSALPAADYEFNAWTRPDCAGTEHENGNRSWFYFSVKGGAPGKLIKINIVNMNKQSKLYSQGMAPFVRTVPGRPRWERVRDRPAFEMAEAQFVLSFVHRFLEPRGATTYFAFCYPFSYTECQDMLAHLDSRLEPCRYLSPISFPHANQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRT4</accession>
    <name>A0A151MRT4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID 70 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TAF6-1</name>
        <name evidence="10" type="ORF">Y1Q_0019579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005281">
        <property type="protein sequence ID" value="KYO27183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRT4"/>
    <dbReference type="STRING" id="8496.A0A151MRT4"/>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000030">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="9">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO27183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="666" mass="69810" checksum="6BC25CDA164685E5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSQ0</accession>
    <name>A0A151MSQ0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">chymotrypsin</fullName>
            <ecNumber evidence="9">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CTRB2</name>
        <name evidence="13" type="ORF">Y1Q_0003683</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="9"/>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSQ0"/>
    <dbReference type="STRING" id="8496.A0A151MSQ0"/>
    <dbReference type="GeneID" id="102565040"/>
    <dbReference type="KEGG" id="amj:102565040"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5918597at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MSQ0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000176">
        <property type="entry name" value="Chymotrypsinogen A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000181">
        <property type="entry name" value="Chymotrypsinogen A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF65">
        <property type="entry name" value="CHYMOTRYPSINOGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0222">Digestion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012113659" description="chymotrypsin" evidence="11">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="34"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO27532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="263" mass="28343" checksum="C81907CB683A2812" modified="2016-06-08" version="1">MALLWLLSCLTLASAAHGCGIPAIHPIISGYTRIVNGEEAIPGSWPWQASLQEKSGWHFCGGSLVGEDWVVTAAHCGVTTSNVVVLGEHDRGSSTEQVQKLAVKKVFTHPKWNPQTIDYDIALIKLATPAKLSRTVSPVCLGETRDHFYSGELCVTTGWGKTRYNAFLTPNKLQQTALPLLSNLQCEEYWGNQITNQMICAGAAGSSSCMGDSGGPLVCPKNGAWYLVGIVSWGSSKCSTTIPAVYARVTEFHEWIALTMASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MT14</accession>
    <name>A0A151MT14_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MT14"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO27648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9587" checksum="E4402C13095A67DA" modified="2016-06-08" version="1">MWGCSAQAPEAPGCYRSDSNIVFGAVGFTSVRIKLPEKMVSPEPFAISELLDLSEALSLQVAKDEGELFMDYSLIRPLMSEPVKYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU77</accession>
    <name>A0A151MU77_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CD109 antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CD109</name>
        <name evidence="20" type="ORF">Y1Q_0014230</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Modulates negatively TGFB1 signaling in keratinocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO28056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MU77"/>
    <dbReference type="eggNOG" id="KOG1366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1940:FF:000003">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000155">
        <property type="entry name" value="complement C3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1418"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="17">
        <location>
            <begin position="460"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="18">
        <location>
            <begin position="681"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="19">
        <location>
            <begin position="1302"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO28056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1438" mass="159316" checksum="1C094FCA80438426" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV58</accession>
    <name>A0A151MV58_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV58"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="7724" checksum="E99986A148BAD367" modified="2016-06-08" version="1">MSPKIQALSRNRSTSGRCEEILCSLSLSLGLRPPIPLPPLVVQRPFVSWSHPGTSQACLVMLGPPPGDADIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX48</accession>
    <name>A0A151MX48_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rna-directed dna polymerase from mobile element jockey-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX48"/>
    <dbReference type="STRING" id="8496.A0A151MX48"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12171" checksum="C5FFEEF9B8FF022F" modified="2016-06-08" version="1">MGQLITNAQEKANLLSGYFASVVYQSQGMPLPIIGRKGPGEGDSLPSINADLVKEHLERLDTFKSAGPDSLHPTVLEELANIIAQPLTQIFKNSWHSGEMPEDWKKANVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYK4</accession>
    <name>A0A151MYK4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vasotocin-neurophysin VT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AVP</name>
        <name evidence="9" type="ORF">Y1Q_0004928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004653">
        <property type="protein sequence ID" value="KYO29525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYK4"/>
    <dbReference type="STRING" id="8496.A0A151MYK4"/>
    <dbReference type="eggNOG" id="ENOG502S21K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005185">
        <property type="term" value="F:neurohypophyseal hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.9.10:FF:000001">
        <property type="entry name" value="oxytocin-neurophysin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.9.10">
        <property type="entry name" value="Neurohypophysial hormone domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000981">
        <property type="entry name" value="Neurhyp_horm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036387">
        <property type="entry name" value="Neurhyp_horm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022423">
        <property type="entry name" value="Neurohypophysial_hormone_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681">
        <property type="entry name" value="NEUROPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681:SF15">
        <property type="entry name" value="VASOTOCIN-NEUROPHYSIN VT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00220">
        <property type="entry name" value="Hormone_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00184">
        <property type="entry name" value="Hormone_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001815">
        <property type="entry name" value="Nonapeptide_hormone_precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00831">
        <property type="entry name" value="NEUROPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00003">
        <property type="entry name" value="NH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49606">
        <property type="entry name" value="Neurophysin II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00264">
        <property type="entry name" value="NEUROHYPOPHYS_HORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585582" evidence="8">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="59"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="105"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001815-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO29525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="161" mass="17181" checksum="D31C5959D08894B7" modified="2016-06-08" version="1">MPEASLPVYFLCLLALSSACYIQNCPRGGKRAFPDTEIRQCMPCGPGNRGNCFGPNICCGEELGCYVGTAETLRCVEENYLPSPCETGGKACGAGGRCAAPGICCSDESCTMDPVCLDEDSDKSRQLSEKNLTILDGSAGDLLLKLMHLANRQQQGKHQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYU5</accession>
    <name>A0A151MYU5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Cadherin EGF LAG seven-pass G-type receptor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Multiple epidermal growth factor-like domains protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">SLC26A5-1</name>
        <name evidence="36" type="ORF">Y1Q_0023125</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor that may have an important role in cell/cell signaling during nervous system formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MYU5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15993">
        <property type="entry name" value="7tmB2_CELSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000021">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000020">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000108">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000089">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000286">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000359">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000084">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000010">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000023">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000029">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000038">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000040">
        <property type="entry name" value="cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000113">
        <property type="entry name" value="Cadherin, EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000044">
        <property type="entry name" value="Cadherin, EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056286">
        <property type="entry name" value="Cadherin_CELSR1-3_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF38">
        <property type="entry name" value="CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23592">
        <property type="entry name" value="Cadherin_CELSR2_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1L1</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">Y1Q_0008292</name>
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    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">KSC_2009_1</strain>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <sequence length="97" mass="11213" checksum="3724D2EB787F5A86" modified="2016-06-08" version="1">MGFFKSSLCTHNILNRFSFHVDLEKTLCFFSLKMENWESETQRTSFTVVFMNTFISAPTILSSPKCDVVILAWKSGSTEFLVWRNSHMPTEVGNKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1W1</accession>
    <name>A0A151N1W1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytohesin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0008269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1W1"/>
    <dbReference type="STRING" id="8496.A0A151N1W1"/>
    <dbReference type="eggNOG" id="KOG0930">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01252">
        <property type="entry name" value="PH_GRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000003">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000009">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029155">
        <property type="entry name" value="SIPAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF320">
        <property type="entry name" value="CYTOHESIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15487">
        <property type="entry name" value="FAM220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="9">
        <location>
            <begin position="175"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="380"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO30639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="60165" checksum="FBC8258051C0F81D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2G4</accession>
    <name>A0A151N2G4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD repeat domain phosphoinositide-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">WIPI1</name>
        <name evidence="9" type="ORF">Y1Q_0016347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273069.1">
        <property type="nucleotide sequence ID" value="XM_006273007.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2G4"/>
    <dbReference type="STRING" id="8496.A0A151N2G4"/>
    <dbReference type="GeneID" id="102570428"/>
    <dbReference type="KEGG" id="amj:102570428"/>
    <dbReference type="CTD" id="55062"/>
    <dbReference type="eggNOG" id="KOG2110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N2G4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000145">
        <property type="entry name" value="WD repeat domain phosphoinositide-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO30948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="443" mass="48783" checksum="0DDC81ACDB929137" modified="2016-06-08" version="1">MEAAAAAAGPEALRCFSYNQDCTSLAIGTDTGYRLFSLNSVEQLDQVHESNETPDVYIVERLFSSSLVVVVSQAKPQQMNVYHFKKGTEICNYSYSSSILSIRLNRQRLIVCLEESIYIHNIKDMKLLKTILDTPANATGLCALSINHSNSYLAYPGSTTTGEIVLYDGNHLKPVCTIPAHDGPLAALTFNSAGSKLASASEKGTVIRVFSVPEGQKLYEFRRGMKRYVNISSLVFSMDSQFLCASSNTETVHIFKLEHLTDSRPEEPPTWSGYMGKMFMAATNYLPAQVSGMMSQDRAFATVRLNFSGQRNICVLSTIQKLPRLLVTTSDGHLYIYNLDPQDGGECILIKKHSLLGPRKMEENKENDLRPPLPQSYAATVARQSTTPSTSSMPGYSEDGGALRGEVIPEHEFATGPVCLDDENEFPPINLCRGSQSGKVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2G9</accession>
    <name>A0A151N2G9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Allergin-1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MILR1</name>
        <name evidence="18" type="ORF">Y1Q_0016376</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2G9"/>
    <dbReference type="STRING" id="8496.A0A151N2G9"/>
    <dbReference type="PhylomeDB" id="A0A151N2G9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090557">
        <property type="term" value="P:establishment of endothelial intestinal barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050892">
        <property type="term" value="P:intestinal absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090559">
        <property type="term" value="P:regulation of membrane permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042456">
        <property type="entry name" value="F11R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040878">
        <property type="entry name" value="IL-40-like_Ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45113">
        <property type="entry name" value="JUNCTIONAL ADHESION MOLECULE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45113:SF1">
        <property type="entry name" value="JUNCTIONAL ADHESION MOLECULE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17736">
        <property type="entry name" value="Ig_C17orf99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0796">Tight junction</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585665" evidence="16">
        <location>
            <begin position="21"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="131"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO30984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="337" mass="37531" checksum="A99BBB1063663A8C" modified="2016-06-08" version="1">MLTFMTLLVLLLSHFQATQQNKNSEENGSELLSNPELKLPNRNSEVTIGQNVTMTCFSGSGSLSINYTLFRDDQKLFTETKSAGMPAKFILNIKSASDTGKHTCKATNEILKKTKYSKSLILTLIETVSQPVLSSPTSRVKTGQNVTLFCLSENGSHPITYRFFRGNKTISPPICVQGKAAANISLTINSSNVLGDYKCKAENRIPNSKKYSNSLRFTLSEKAGISYLLWISLLVFLLLVVIVIAVAIPFLFLPWYKARKLKSPKSSTGFVSDKTESENCVIYTEIANDESDQLQYANISIIRKEKGDKRVNLSTDTVNYSEVFISRIQGKKTFIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N333</accession>
    <name>A0A151N333_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N333"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO31243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="8914" checksum="4CE686B8C2AE5990" modified="2016-06-08" version="1">MEGPGLRKGIYREEQADEQRGTIQVTHFDQSPVTSSDMSGYTKHTTKFPTILVSCECCVKDGSFLNDVKEVHRPPWVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4I2</accession>
    <name>A0A151N4I2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylethanolamine-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">HCNPpp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PEBP1</name>
        <name evidence="15" type="ORF">Y1Q_0022818</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatidylethanolamine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266472.1">
        <property type="nucleotide sequence ID" value="XM_006266410.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4I2"/>
    <dbReference type="STRING" id="8496.A0A151N4I2"/>
    <dbReference type="GeneID" id="102561932"/>
    <dbReference type="KEGG" id="amj:102561932"/>
    <dbReference type="CTD" id="5037"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N4I2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000003">
        <property type="entry name" value="phosphatidylethanolamine-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001858">
        <property type="entry name" value="Phosphatidylethanolamine-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF151">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01220">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0722">Serine protease inhibitor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO31734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="187" mass="21118" checksum="B6331A62EDE3BC22" modified="2016-06-08" version="1">MPLQLAQWGGPLSLGEVEQQPTQPLRVKYGSVEIDELGKVLTPTQVQSRPTSIEWDGCDPQKLYTLVLTDPDAPSRKDPKFREWHHFLVTNMKGNDIKSGQVLSDYVGSGPPKGTGLHRYVWLVYEQPQQLTCDEPILSNRSGDHRGKFKVASFRNKYKLGVPVAGTCYQAEWDDYVPKLYEQLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6W4</accession>
    <name>A0A151N6W4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="19">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Y1Q_0020421</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 19">Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Can hydrolyze GTP, ATP and UTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>UTP + H2O = UDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:64901"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion outer membrane</location>
            <topology evidence="1 19">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6W4"/>
    <dbReference type="STRING" id="8496.A0A151N6W4"/>
    <dbReference type="KEGG" id="amj:102571083"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N6W4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000021">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 19" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="22">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="22">
        <location>
            <begin position="416"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO32491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="618" mass="69952" checksum="8AD6EC6C0566DFD1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6X0</accession>
    <name>A0A151N6X0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Septin-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SEPT12</name>
        <name evidence="11" type="ORF">Y1Q_0020427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6X0"/>
    <dbReference type="STRING" id="8496.A0A151N6X0"/>
    <dbReference type="eggNOG" id="KOG1547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000143">
        <property type="entry name" value="septin-9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="89"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO32497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="383" mass="43811" checksum="7FDAD756D9BE392F" modified="2016-06-08" version="1">MPGSYPMETPNMGMTGPPEVASVPEVHSREKTKEGSSPEPGWISMEEQPLQAAQEGAPHDVPGKVGHELFGYVGIEAVLDQMRIKTMKTGFEFNIMVVGQSGLGKSTMVNTLFKSKVSCKATTPRHEERIPKTVQLQSVTHVIEEKGVKMKLTVTDTPGFGDQINNENCWDPIIKYINEQYERYLREEILISRKQKIPDTRVHSCVYFVPPTGHWLRPLDLEFMRRLSKIVNVVPVIAKADTLTLEERAEFKQRIQRDLKAHGISIYPQEDFEEDPDERILNDKIRDKIPFAVVGADQEHQVNGKRILGRKTKWGIIEVENPSHCEFPMLRDLLIRSHLQDLKDITHNMHYESYRVRRLNESNRLALSPVNGLQEKDEVESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6Z0</accession>
    <name>A0A151N6Z0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="11">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHST8</name>
        <name evidence="12" type="ORF">Y1Q_0007799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03003905">
        <property type="protein sequence ID" value="KYO32614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6Z0"/>
    <dbReference type="STRING" id="8496.A0A151N6Z0"/>
    <dbReference type="eggNOG" id="KOG4651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF7">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO32614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="428" mass="50766" checksum="F3C08B4FED73869E" modified="2016-06-08" version="1">MEMQTPLNYTALLSRDSLTSLSWDVISVTESKRIKYNMGLQQPKKDCTSNNNQDGRIRKTTADELSVVKQRGSLYPPENAPTMLQSRDRSENNIMFLVKDHQKKGAETNSIRFHKRRRRFVIKKSPILIAMNSSTLNLPTLKSEDRNNDKWKSLYQIQKQRKRIMRETCSKYKSNNRRIITPYHVSRIFVEDKYRILYCEVPKAGCSNWKRVLMVLNGLASSTKDIQHNTVHYGNYLKRLDGFDRKGIYHRLNTYTKMLFIREPFEKLVSAFRDKFEHPNNYYHPVFGKAIISRYRVNATKEALRTGSGVKFKEFIQYLLDVHRPVGMDIHWDHVNRLCSPCLIDYDFVGKFESMEEDANFFLHLIGAPQNLTFPKFKDRHSNEERTTTKITQQYFAQLSPSQRQRSYDFYYMDYLMFNYSKPFEDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N964</accession>
    <name>A0A151N964_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-2-oxoglutarate aldolase, mitochondrial</fullName>
            <ecNumber evidence="4">4.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dihydrodipicolinate synthase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Probable 2-keto-4-hydroxyglutarate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HOGA1</name>
        <name evidence="15" type="ORF">Y1Q_0020565</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the final step in the metabolic pathway of hydroxyproline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:30687"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:62213"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:35639"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:71685"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03003692">
        <property type="protein sequence ID" value="KYO33354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N964"/>
    <dbReference type="STRING" id="8496.A0A151N964"/>
    <dbReference type="GeneID" id="102563093"/>
    <dbReference type="KEGG" id="amj:102563093"/>
    <dbReference type="CTD" id="112817"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:(R,S)-4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="13">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO33354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="328" mass="34955" checksum="4AB30000A5BE8A00" modified="2016-06-08" version="1">MALTAPLRLGGRGWRPGVLGRVLSTAPTKPAPRLDLRGIYPPLATPFMAQGGVDYARLEDNLRLYAQVPFRGFVVQGSNGECPLLTGPERLDIVARVRRAVPRPRLLLAGSGCESTQATIELTAGMAEAGADAVLVVTPCYYRGAMSTAALVLHYTQVAEASPVPVVLYSVPANTGLELPLEAVLALAPHPNVVGLKDSGGDITRLGLIVHKTRREDFQVLAGSAGFLLASYAVGAVGGVCALANVLGAPLCQLERLCQEGRWQEARDLQHRLIEPNAAVTRRFGVAGLKQAMEWFGYHGGPCRAPLLPLSEDQAAALRRAFTRNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAM2</accession>
    <name>A0A151NAM2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003672">
        <property type="protein sequence ID" value="KYO33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAM2"/>
    <dbReference type="STRING" id="8496.A0A151NAM2"/>
    <dbReference type="OrthoDB" id="2126613at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="707" mass="82063" checksum="6CE5F4C5BA133FAE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAM5</accession>
    <name>A0A151NAM5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0024466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAM5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7198" checksum="EAA083D9BB3C35E1" modified="2016-06-08" version="1">MARSKKYADMVKRPGSPYSGKNRTLKSFQGYCSSLCLGTSAGAEISSKKEADNVGHTFTALNLPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCQ2</accession>
    <name>A0A151NCQ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bag6 BAG-similar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0017188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003389">
        <property type="protein sequence ID" value="KYO34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCQ2"/>
    <dbReference type="STRING" id="8496.A0A151NCQ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048926">
        <property type="entry name" value="Bag6_BAGS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20960">
        <property type="entry name" value="Bag6_BAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bag6 BAG-similar" evidence="2">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="164" mass="17900" checksum="36D0AD12F56768F8" modified="2016-06-08" version="1">MAERDSAGSPAPATTAEEALAPRPEPPPDPPGQAPPASEPEAWAAAVPPEWVPIIRQDIQAQRKGKQQPPLSDAYLTGMPAKRRKTMQGDGPQLLLAEAVSRAARATGVQTSSPEELRRDLAQPPLQEAYRRQLKSDLQKRLQDDPSFSPQRFPNAQRAFVEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NE67</accession>
    <name>A0A151NE67_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase RNF170</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING finger protein 170</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase RNF170</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RNF170</name>
        <name evidence="21" type="ORF">Y1Q_0000972</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019346213.1">
        <property type="nucleotide sequence ID" value="XM_019490668.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NE67"/>
    <dbReference type="STRING" id="8496.A0A151NE67"/>
    <dbReference type="GeneID" id="102562450"/>
    <dbReference type="CTD" id="81790"/>
    <dbReference type="eggNOG" id="KOG2164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16553">
        <property type="entry name" value="RING-HC_RNF170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038896">
        <property type="entry name" value="RNF170"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="338" mass="38623" checksum="A1E5DFE41F61362D" modified="2016-06-08" version="1">MQRLLRRAPDRRHLGDTEGSRVRPPSRAPLPFAASPFSASLPHGFAKVFASWSVGFGWQTGKNVPWRLLTSDFPKTYFTRPGMASQQAEVQSLKLSNDSIIEGVSDQVLVAVVLSFSFIAALVYMLLRNEHQNIHPENQELVRALRQQLQTEQDESAGDRHHFYTDMSCPVCLQQATFPIETNCGHLFCGACIIAYWRYGSWLGAIRCPICRQTVTLFLPLFGEDQPDAAQVLQDVSDYNRRFSGQPRSIMERIMDLPTLLRHAFREMFSVGGLFWMFRIRIFLCLLGALLYLASPLDFLPEALFGILGFLDDFFVIFLLLIYISIMYREVVTQRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG45</accession>
    <name>A0A151NG45_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG45"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="148" mass="16500" checksum="5DB792A3A11B3EEA" modified="2016-06-08" version="1">MRRSKRKAKLPSSVSTSLKQVLVFLIAFTTYSTISLYFFNDVTVSLHDIWGLETPKVLEVEILSKLRWQDSAFDPVETNLRSLQSGSTLPCTCGWSHFVNALDEPNTDACILPGGRSPQALHTGRSPAEINQVMHELGVTQTDNHSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHB6</accession>
    <name>A0A151NHB6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0019585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002979">
        <property type="protein sequence ID" value="KYO36188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHB6"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="5">
        <location>
            <begin position="462"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO36188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="671" mass="73458" checksum="5335C12173BA08C9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJC2</accession>
    <name>A0A151NJC2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leptin receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">OB receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">IL23R-1</name>
        <name evidence="19" type="ORF">Y1Q_0020911</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="15">Present as a mixture of monomers and dimers. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJC2"/>
    <dbReference type="STRING" id="8496.A0A151NJC2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000465">
        <property type="entry name" value="Granulocyte colony-stimulating factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000414">
        <property type="entry name" value="Interleukin-6 receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003529">
        <property type="entry name" value="Hematopoietin_rcpt_Gp130_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003531">
        <property type="entry name" value="Hempt_rcpt_S_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052672">
        <property type="entry name" value="Type1_Cytokine_Rcpt_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015321">
        <property type="entry name" value="TypeI_recpt_CBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423:SF2">
        <property type="entry name" value="INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09240">
        <property type="entry name" value="IL6Ra-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01353">
        <property type="entry name" value="HEMATOPO_REC_L_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01355">
        <property type="entry name" value="HEMATOPO_REC_S_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="317"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="555"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO36891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="742" mass="83653" checksum="60FA07D8783EE05F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJT7</accession>
    <name>A0A151NJT7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJT7"/>
    <dbReference type="STRING" id="8496.A0A151NJT7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF3">
        <property type="entry name" value="FRAS-RELATED EXTRACELLULAR MATRIX PROTEIN 1B PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO36949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="150" mass="16477" checksum="7E1CA61E1F52BA7D" modified="2016-06-08" version="1">MKGDIVLLTKPVTLTEGDRVTLTTDVLMATDGTSKPEKLLYAVSMPPVHGQIEYINYPGVPISSYSQFGCGGPEGQMNRSGQLEFNIEYTDHIPPTLVNNKGIHVVESGMGVISSDVLQLIDLDSPLKNLTYIVTQHPQYGHLYMKETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NL64</accession>
    <name>A0A151NL64_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipid phosphate phosphohydrolase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0015775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002666">
        <property type="protein sequence ID" value="KYO37552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NL64"/>
    <dbReference type="STRING" id="8496.A0A151NL64"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NL64"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF94">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE TYPE 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="6">
        <location>
            <begin position="138"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO37552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="280" mass="30094" checksum="F2EA425F8DEA8CF0" modified="2016-06-08" version="1">MHTGEGGFHPPSPSPWTPAPRELQVTVRGPSTQIDQCPGLGWRPRKTLVALDIACLLMAAVPFLLCELGLVPPVRRGFYCNDSSIRYPLTAAETVSDGALVSIGLLLSATTIALGESYRVRRQGLGPQAYAPALYKELGAFLFGCTVGQSLTNVAKVAVGRLRPHFLAVCRPDMALVDCSRGYVEAYICTASPSEEKEARKSFYSGHASFAMYTMTYLVLYMQAQGAGRRAPRALLQATLLLLALGTGLTRVAEHRHHPADVAAGLLQGILVATWAVQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLT4</accession>
    <name>A0A151NLT4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sciellin isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SCEL-1</name>
        <name evidence="7" type="ORF">Y1Q_0017247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLT4"/>
    <dbReference type="STRING" id="8496.A0A151NLT4"/>
    <dbReference type="eggNOG" id="KOG1704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052621">
        <property type="entry name" value="Cell_Prolif/Cornif_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15468:SF7">
        <property type="entry name" value="SCIELLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15468">
        <property type="entry name" value="ZNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="339"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO37445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="408" mass="45993" checksum="8C6280B80F5BF5D1" modified="2016-06-08" version="1">MISQKDSSLNKMSTFSTQKSSNQTDIRNPSVAVKSRQQVIQDNNKRRTLLQDNSWIKKRSEEENTDENYGRAVLNQYKSQDGLHRNVNEKEDQKVYLGRYRSDTSLDKISDRSDVEKANKSPVLDKKPTNRQSWAPTTSVTTTDTTSTSPVKKKRQSWMPPPVSGYKVSTDSVETKRQDQTLPNTATTRTTDTKRTISSSEQITSQRSTTSVEEQTTTREVSPVSPADTERRSTTERTTRGKDLDDLNAVNSAAQKDKRGQDLVDVIEVKKSVDQNKKGTTEQVSVFAMVPNNQSGTNYLDDTKKGSSKSTNDAQEENVTGKSIKTVYSTSDRTIIEKDMCTYCRKPLGIGAKMILDALQICCHSTCFKCEVCKRPLEDLKAGDSIWIYRKAVHCVPCYAKAKEKWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNG3</accession>
    <name>A0A151NNG3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein FAM155B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FAM155B</name>
        <name evidence="7" type="ORF">Y1Q_0015633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NALF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNG3"/>
    <dbReference type="STRING" id="8496.A0A151NNG3"/>
    <dbReference type="eggNOG" id="ENOG502QQKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015275">
        <property type="term" value="F:stretch-activated, monoatomic cation-selective, calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055288">
        <property type="entry name" value="NALCN_aux_factor_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819:SF8">
        <property type="entry name" value="NALCN CHANNEL AUXILIARY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN FAM155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO38382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="176" mass="19789" checksum="908F085D7C363DBF" modified="2016-06-08" version="1">MAGPDSLDCSLDNLMVDFVAAAAGALDGEACSSCVQAYQRLDQHAQEKYEEFDLLLEKYLQAEEYSVRSCLRDCKAVYKAWLCSEFFNVTQQQCQHRIPCKQYCLEVQTRCPFVLPDNDELIYGGLPGFICTGLLENQLSNEEAKCCDVQWDSCDHPPDSNYNTSPKSTEKLILSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPY2</accession>
    <name>A0A151NPY2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">F-box DNA helicase 1</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">DNA 3'-5' helicase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">F-box only protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">FBXO18</name>
        <name evidence="24" type="ORF">Y1Q_0023500</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPY2"/>
    <dbReference type="STRING" id="8496.A0A151NPY2"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22095">
        <property type="entry name" value="F-box_FBXO18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18786">
        <property type="entry name" value="SF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000011">
        <property type="entry name" value="F-box DNA helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF30">
        <property type="entry name" value="F-BOX DNA HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="23">
        <location>
            <begin position="205"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO38838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1024" mass="115299" checksum="BB2376D5BE2BD6C1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPY8</accession>
    <name>A0A151NPY8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative exosome complex component RRP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EXOSC4</name>
        <name evidence="11" type="ORF">Y1Q_0020568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the RNA exosome complex which has 3'-&gt;5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the RNA exosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002430">
        <property type="protein sequence ID" value="KYO38891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPY8"/>
    <dbReference type="STRING" id="8496.A0A151NPY8"/>
    <dbReference type="KEGG" id="amj:102558508"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO38891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="188" mass="20439" checksum="7D03BA477E150F82" modified="2016-06-08" version="1">MRGSRSKALHDRALVNCQYSMATFSTGERKRRPHGDRKSSEMTLHLKQTFEAAILTQLYPRSQIDIYVQILQADGGNYCACVNAATLAVIDAGIPMQDYVCASSAGFVEDTALADLNYVEEAAGGPQVALALLPKSDQIALLEMNARLHEDHLECVLDAATAACRAVHAVLDQVVRDHVREVATLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NR42</accession>
    <name>A0A151NR42_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Kv channel-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KCNIP1</name>
        <name evidence="14" type="ORF">Y1Q_0004872</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002337">
        <property type="protein sequence ID" value="KYO39244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019342675.1">
        <property type="nucleotide sequence ID" value="XM_019487130.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NR42"/>
    <dbReference type="STRING" id="8496.A0A151NR42"/>
    <dbReference type="GeneID" id="102574292"/>
    <dbReference type="CTD" id="30820"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000043">
        <property type="entry name" value="Kv channel-interacting protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF82">
        <property type="entry name" value="KV CHANNEL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO39244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="232" mass="26948" checksum="80D16432CA8B73D2" modified="2016-06-08" version="1">MWNEGESEGLQTLGIVVVVCSSLKLLHYLGLIDLSDDKIEDELEMTTVCHRPEGLEQLEAQTNFTKRELQVLYRGFKNECPSGIVNEETFKQIYAQFFPHGDASMYAHYLFNAFDTAQNGSVKFEDFVTALSILLRGTVHEKLRWTFNLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKEDAPRQHVEVFFQKMDKNKDGVVTLDEFIESCQEDDNIMRSLQLFENVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUQ9</accession>
    <name>A0A151NUQ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="33">Dynamin-2</fullName>
            <ecNumber evidence="8">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="39" type="ORF">Y1Q_0008993</name>
    </gene>
    <organism evidence="39 40">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="39 40" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Phagocytic cup</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="32">Cell projection</location>
            <location evidence="32">Uropodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="30">Cytoplasmic vesicle</location>
            <location evidence="30">Phagosome membrane</location>
            <topology evidence="30">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <location evidence="7">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Synapse</location>
            <location evidence="28">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="34">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="39">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03001975">
        <property type="protein sequence ID" value="KYO40309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUQ9"/>
    <dbReference type="STRING" id="8496.A0A151NUQ9"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="Dynamin_GTPase"/>
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        <property type="entry name" value="Dynamin_GTPase_CS"/>
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        <property type="entry name" value="Dynamin_stalk"/>
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        <property type="entry name" value="G_DYNAMIN_dom"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_DOMAIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0007">Acetylation</keyword>
    <keyword evidence="18" id="KW-0965">Cell junction</keyword>
    <keyword evidence="26" id="KW-0966">Cell projection</keyword>
    <keyword evidence="24" id="KW-0168">Coated pit</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="27" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="25" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0967">Endosome</keyword>
    <keyword evidence="21 34" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="23" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14 34" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0770">Synapse</keyword>
    <keyword evidence="12" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="38">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="36">
        <location>
            <begin position="515"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="37">
        <location>
            <begin position="649"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="738"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="35">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="35">
        <location>
            <begin position="824"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004231"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
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    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
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    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00046301"/>
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    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00050873"/>
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    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00060447"/>
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    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00073712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="EMBL" id="KYO40309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="858" mass="96834" checksum="5171E7156923030E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWH1</accession>
    <name>A0A151NWH1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inactive tRNA-specific adenosine deaminase-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ADAT3</name>
        <name evidence="5" type="ORF">Y1Q_0007001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001653">
        <property type="protein sequence ID" value="KYO41252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006271913.3">
        <property type="nucleotide sequence ID" value="XM_006271851.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059575332.1">
        <property type="nucleotide sequence ID" value="XM_059719349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWH1"/>
    <dbReference type="STRING" id="8496.A0A151NWH1"/>
    <dbReference type="GeneID" id="102562664"/>
    <dbReference type="KEGG" id="amj:102562664"/>
    <dbReference type="CTD" id="113179"/>
    <dbReference type="eggNOG" id="KOG2771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NWH1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="159"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO41252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="330" mass="36080" checksum="7C7CF853B3BC59EA" modified="2016-06-08" version="1">MEPDCKRRRRQSGGEVVAWVPEPVLSELESRGVELVSAYAAPILLKAETSRLVQELALALPLTGLPHLKRVRARATGLEVLVCLAEDGAIPQTLAQLLPHSRVHTHGLGEPFLVRVPARPPLTRRQFEEAAAHWPTAFHENKRTSRALDGTLFTAQECVSMARHMEQALDAACHGAELGMVPAGVAVVDPATGCVLAVGHDCRRGLHPLLHAAMVGIDLVAHGQGGGAYSYRDFASCSFQPLVDGSPHEGLPYICTGYDMYLTREPCAMCAMALVHARIRRVFYGVPAPQGALGSCYHMHSRRDLNHRYEVFRGVLEGPCRRLGMERLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWH2</accession>
    <name>A0A151NWH2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001861">
        <property type="protein sequence ID" value="KYO40775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWH2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10451" checksum="CC235FFE88B2CC37" modified="2016-06-08" version="1">MDPSLFEVPRGYSVVGSHPDTAREDDDDLLQFAIQQSLLEAGSEYDQVGAVPCRAVPRCAPTPRREGPFGRQRRGQQGVNALLHAHHCRSPSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX73</accession>
    <name>A0A151NX73_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DAPK3</name>
        <name evidence="17" type="ORF">Y1Q_0011892</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006278741.1">
        <property type="nucleotide sequence ID" value="XM_006278679.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX73"/>
    <dbReference type="STRING" id="8496.A0A151NX73"/>
    <dbReference type="GeneID" id="102559675"/>
    <dbReference type="KEGG" id="amj:102559675"/>
    <dbReference type="CTD" id="1613"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NX73"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14105">
        <property type="entry name" value="STKc_DAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000110">
        <property type="entry name" value="Death-associated kinase 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000250">
        <property type="entry name" value="Death-associated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042870">
        <property type="entry name" value="DAPK3_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF18">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="325"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO41179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="456" mass="53291" checksum="33C5DFD815F93105" modified="2016-06-08" version="1">MSTFRQEDVELHYDMGEELGSGQFAIVRKCREKKTNLEYAAKFIKKRRLSSSRRGVSREEIEREVDILREIQHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEEEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKKRMTIAQSLEHPWIKVIKRRNVRNEDNGKKPERRRLKTTRLKEYTIKSHSSMPPNNTYINFERFSKVMEEVAAAEESLRELEKTKKSFREDVEALLSIYNEKESWYKEENESISQDLRQIRQELQKTETLKKQAQEETRSMLQAANGLKRRYRKLENRYEALAKQVASEMKFVQELVWSLEQEKLQGGEGDCSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXN3</accession>
    <name>A0A151NXN3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0006388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXN3"/>
    <dbReference type="STRING" id="8496.A0A151NXN3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF86">
        <property type="entry name" value="CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase" evidence="5">
        <location>
            <begin position="59"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO41641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="198" mass="23517" checksum="879D7140C65EEE7A" modified="2016-06-08" version="1">MGVQKGMVASWWNHLHNQHHAKPNCFRKDPDLNMHPILFSLGKTLSIEELFLIVTYNIRVCFMYVPLMGFKSFMAYYWLARYLESTWFIWVSQMNHIPMHIDYDRNLDWVSTQLQATCNVNQSWFNDWFTGHLNFQIEHHLFPTMPRHNYWKVAPLVKSLCATHGIEYKSKTLLTAFADILHSLKDSGEHWLDAYLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYR6</accession>
    <name>A0A151NYR6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYR6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="105" mass="11610" checksum="B3ECACCB94D0510C" modified="2016-06-08" version="1">MRQVRAAVEGRGAPPPTPPGTSVTAAQRKAGASDVSKRRRAVAMGTKMEIIRRSEKGERRTATGRALGLDRGPVATVRKDEVRKITDYGYRGNMQSDKQCWKQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P011</accession>
    <name>A0A151P011_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myosin regulatory light polypeptide 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MYL9</name>
        <name evidence="7" type="ORF">Y1Q_0002844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Myosin is a hexamer of 2 heavy chains and 4 light chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P011"/>
    <dbReference type="STRING" id="8496.A0A151P011"/>
    <dbReference type="eggNOG" id="KOG0031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000010">
        <property type="entry name" value="Myosin regulatory light chain 2, atrial isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO42230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="212" mass="24475" checksum="5BD06E534EA2BAFF" modified="2016-06-08" version="1">MKLQDQLHICTFLEMKGVRNAFGISWFLTVSDRERTPPAKMSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLEGMMSEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEDATGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P032</accession>
    <name>A0A151P032_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protocadherin-15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PCDH15</name>
        <name evidence="16" type="ORF">Y1Q_0022234</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050957">
        <property type="term" value="P:equilibrioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050953">
        <property type="term" value="P:sensory perception of light stimulus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
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        <property type="entry name" value="protocadherin-15 isoform X1"/>
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        <property type="entry name" value="Cadherin-like_dom"/>
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        <property type="entry name" value="Cadherin-like_sf"/>
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        <property type="entry name" value="Cadherin_CS"/>
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        <property type="entry name" value="EC_dom"/>
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    <dbReference type="InterPro" id="IPR056989">
        <property type="entry name" value="PCDH15_12th_dom"/>
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    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF442">
        <property type="entry name" value="PROTOCADHERIN-15 ISOFORM X1"/>
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    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
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    <dbReference type="Pfam" id="PF18432">
        <property type="entry name" value="ECD"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF23206">
        <property type="entry name" value="PCDH15_12th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1347"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="119"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
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    </feature>
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    </feature>
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    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
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        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="791"/>
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        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="898"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1008"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1116"/>
            <end position="1230"/>
        </location>
    </feature>
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        <location>
            <begin position="1514"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1593"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1593"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1647"/>
            <end position="1662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO42384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1682" mass="186373" checksum="EE6D6E352CB9C7A3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0X3</accession>
    <name>A0A151P0X3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001351">
        <property type="protein sequence ID" value="KYO42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0X3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="124" mass="14085" checksum="467C73ABA10A55A0" modified="2016-06-08" version="1">MFLLTDMLSTLHVYRRDRFKSAEAGCYKIGGFDLLSYAPHMKHGKATYVWSDIMDEESPDFCDAIQVGGFQVANVYKPPKSTGTNKFHQLCLIQPFMLESLTATFTAMDWGYMDVDANDEQHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2G3</accession>
    <name>A0A151P2G3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DCTN1</name>
        <name evidence="17" type="ORF">Y1Q_0023916</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001223">
        <property type="protein sequence ID" value="KYO43089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2G3"/>
    <dbReference type="STRING" id="8496.A0A151P2G3"/>
    <dbReference type="eggNOG" id="KOG0971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000003">
        <property type="entry name" value="dynactin subunit 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="16">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="101"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="934"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO43089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1257" mass="139753" checksum="5BFE9608E6E08D90" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2W9</accession>
    <name>A0A151P2W9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001229">
        <property type="protein sequence ID" value="KYO43085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2W9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="81" mass="8802" checksum="6185D484CF613D82" modified="2016-06-08" version="1">MDRGLPSRHIASPSGPSIMDVFSACGATTHRVGAMAWLCLLGDWLLCSLWLRGSCRFLLPTSLCVSDTCHRDKSRSPEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P321</accession>
    <name>A0A151P321_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Speedy protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPDYA</name>
        <name evidence="3" type="ORF">Y1Q_0013525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Speedy/Ringo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P321"/>
    <dbReference type="STRING" id="8496.A0A151P321"/>
    <dbReference type="eggNOG" id="KOG3938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020984">
        <property type="entry name" value="Speedy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052316">
        <property type="entry name" value="Speedy-Ringo_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545">
        <property type="entry name" value="SEEDY PROTEIN A/C FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545:SF4">
        <property type="entry name" value="SPEEDY PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11357">
        <property type="entry name" value="Spy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO43466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="243" mass="28284" checksum="BDA7E0B8641342DE" modified="2016-06-08" version="1">MTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRANFNINEHTRLNFFVALYLANTVEEDDEESKYEIFPWALGKTWRKLFPDFLKLRDQLWSRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSMHHSGAVRNYSRDEVQMPRGPSATPIDCSLCGKKGRFVGLGLSSSSSSSTGTLEMMELYPSQELKDTFPVEKMLIDPPTSSYFQDCISLSTRGRKGGCMNQDKSMDWFTGNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3P6</accession>
    <name>A0A151P3P6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC30A1</name>
        <name evidence="9" type="ORF">Y1Q_0013648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3P6"/>
    <dbReference type="STRING" id="8496.A0A151P3P6"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF1">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO43643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="242" mass="26262" checksum="E7904905B2E0D421" modified="2016-06-08" version="1">MLALTFVFFVMEVVVSRLTASLAMLSDSFHMLSDVMALVVALVAVRFAQRTRATKKNTFGWVRAEVMGALVNAVFLTALCFTILLEAIERFTEPHEIQQPLVVLVAGVAGLIINLLGLCLFHQHGHGHSHGHAHGAAPPPPRAKLQRCPGEGDAALHKEETNMLVDNYSGPNGLSQEQLGDIEKDGKDDLQMNGNAGRHSLDIDVEDTSGQLNMRGVFLHVLGDALGYGYADLLLKIVIPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4Z4</accession>
    <name>A0A151P4Z4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Prenylcysteine oxidase 1</fullName>
            <ecNumber evidence="10">1.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PCYOX1</name>
        <name evidence="19" type="ORF">Y1Q_0013943</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides. Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:30231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15894"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:62141"/>
            <dbReference type="EC" id="1.8.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(2E,6E,10E)-geranylgeranyl]-L-cysteine + O2 + H2O = (2E,6E,10E)-geranylgeranial + L-cysteine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:70407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:189549"/>
            <dbReference type="ChEBI" id="CHEBI:189554"/>
            <dbReference type="EC" id="1.8.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70408"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an S-polyprenyl-L-cysteine + O2 + H2O = a polyprenal + L-cysteine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:53892"/>
            <dbReference type="Rhea" id="RHEA-COMP:13675"/>
            <dbReference type="Rhea" id="RHEA-COMP:13676"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:137934"/>
            <dbReference type="ChEBI" id="CHEBI:137935"/>
            <dbReference type="EC" id="1.8.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:53893"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.5" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03000870">
        <property type="protein sequence ID" value="KYO44134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006268797.2">
        <property type="nucleotide sequence ID" value="XM_006268735.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4Z4"/>
    <dbReference type="STRING" id="8496.A0A151P4Z4"/>
    <dbReference type="GeneID" id="102574611"/>
    <dbReference type="KEGG" id="amj:102574611"/>
    <dbReference type="CTD" id="51449"/>
    <dbReference type="eggNOG" id="ENOG502QSHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000081">
        <property type="entry name" value="prenylcysteine oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF3">
        <property type="entry name" value="PRENYLCYSTEINE OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586676" description="Prenylcysteine oxidase 1" evidence="17">
        <location>
            <begin position="28"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="18">
        <location>
            <begin position="124"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO44134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="501" mass="55909" checksum="4D440398CBD04C2F" modified="2016-06-08" version="1">MDVRSAQYLPAAFLLLLLGCVWSQALGNAPDRIAVIGAGIGGTSAAYYLRQKFGRDVQIDLFEREAVGGRLATIRVEGKEYEAGGSVIHPLNLHMKAFVKELGLSPTQGQNHLAGIYSGDRFVFEESGWYIITVLKLLWQYWLNPLRIYMWVEDIMDKFMRIYRYQDNDYAFTSTEKLVSALGGDYFLQLLNETIGRALQKTGFSQTFINEVVTPVMRVNYGQTVNINGFVGAVSLAGADSGLWSVTGGNKRVCDGLLSASKAQLIPSTVTSVEMITQPRASGGKTQQYEICYNSTSGVAIAHYDIVVIATPLNHKMSNITFWNFNPPIPEFSRPYHQTIATFIHGQINTSFFGYQDSSSFHIDGIFTTDNPKLFINSMGVVSPVQNEQDKLEQSLGSAVWKVFSKEPLTEEQINLLFSSYDSVKAKQWLAYPHYSSPKKCPPFILHDQMYYLSGIECAASAMEMSAIAAKNVALLAHHRWYGNTDKIDQEGLHEKLKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P569</accession>
    <name>A0A151P569_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000840">
        <property type="protein sequence ID" value="KYO44202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P569"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="122" mass="13819" checksum="A3B42B36AADE2748" modified="2016-06-08" version="1">MRIENGLDDSDADDVTGSGGKKRKRPGKYRQSQIQIKRLFEIRKRGILPTLALLWIVSLVPTEIPSSLGGLLRRNLSPTQAAGVKDDFKRVLIFNAIDLLGALVEKEKHWEREEKGKELKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5S2</accession>
    <name>A0A151P5S2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LMTK3</name>
        <name evidence="17" type="ORF">Y1Q_0010999</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000769">
        <property type="protein sequence ID" value="KYO44408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P5S2"/>
    <dbReference type="eggNOG" id="ENOG502R1RA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14206">
        <property type="entry name" value="PTKc_Aatyk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000347">
        <property type="entry name" value="Apoptosis associated tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000275">
        <property type="entry name" value="Apoptosis associated tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE LMTK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE LMTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="160"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="593"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="706"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="956"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1026"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1202"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1339"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1449"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1511"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1550"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1029"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1056"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1219"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1248"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1383"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1449"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1517"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO44408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1571" mass="170579" checksum="E738CED68616CD24" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P605</accession>
    <name>A0A151P605_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydropyrimidinase-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0016752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000764">
        <property type="protein sequence ID" value="KYO44443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P605"/>
    <dbReference type="STRING" id="8496.A0A151P605"/>
    <dbReference type="KEGG" id="amj:106736762"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P605"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.40.10:FF:000021">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.40.10:FF:000022">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF56">
        <property type="entry name" value="DIHYDROPYRIMIDINASE-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="64"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO44443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="572" mass="62343" checksum="054BBD1E0D9821EC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7F6</accession>
    <name>A0A151P7F6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">MET</name>
        <name evidence="30" type="ORF">Y1Q_0016642</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03000647">
        <property type="protein sequence ID" value="KYO44849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P7F6"/>
    <dbReference type="eggNOG" id="KOG1095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01179">
        <property type="entry name" value="IPT_plexin_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05058">
        <property type="entry name" value="PTKc_Met_Ron"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000093">
        <property type="entry name" value="Hepatocyte growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000679">
        <property type="entry name" value="Macrophage stimulating 1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000251">
        <property type="entry name" value="Macrophage stimulating 1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000194">
        <property type="entry name" value="Macrophage-stimulating 1 receptor a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000006">
        <property type="entry name" value="Macrophage-stimulating 1 receptor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016244">
        <property type="entry name" value="Tyr_kinase_HGF/MSP_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000617">
        <property type="entry name" value="TyrPK_HGF-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17 30" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="1117"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="29">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="1056"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1345"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="1349"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="1182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="1062"/>
            <end position="1070"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 25">
        <location>
            <position position="1088"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="1135"/>
            <end position="1138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by autocatalysis" evidence="23">
        <location>
            <position position="1212"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by autocatalysis" evidence="23">
        <location>
            <position position="1213"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by autocatalysis" evidence="23">
        <location>
            <position position="1327"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by autocatalysis" evidence="23">
        <location>
            <position position="1334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="100"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="263"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000617-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000617-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000617-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KYO44849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1364" mass="152068" checksum="D86A808C8FF712C0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9S0</accession>
    <name>A0A151P9S0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein kinase 32B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0021397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9S0"/>
    <dbReference type="STRING" id="8496.A0A151P9S0"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000158">
        <property type="entry name" value="Serine/threonine-protein kinase 32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000676">
        <property type="entry name" value="serine/threonine-protein kinase 32B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000735">
        <property type="entry name" value="serine/threonine-protein kinase 32B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF33">
        <property type="entry name" value="SERINE_THREONINE KINASE 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO45744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="414" mass="48146" checksum="9A5505B103DB8608" modified="2016-06-08" version="1">MWKKLWNNMGGNHSHKTPVFDENEDVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFNEGTVKLYICELALSLDYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATIVKGSEKASSMAGTKPYMAPEVFQAFMDGGPGYSYPVDWWSLGITAYELLRGWRPYEIHSTTPIDEILNMFKIERVHYSSTWCKGMIALLKKLLTKDPECRLSSLADVQSSPYLADMNWDAVLEKSVTPGFVPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNKSKDGAKESCPLNVHLQQCLETVRKEFIIFNREKRGSQGRRDAESLTGRRVCLCLEREKASWWIESSSPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9Y9</accession>
    <name>A0A151P9Y9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9Y9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7268" checksum="A3B344D3C5A0CCF0" modified="2016-06-08" version="1">MASEGECQGWMSSHSQLAKSGLCFGSPIPATLLVPSGILPALHLSSFRAPTRTLCFKTGALQEEGGKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PB96</accession>
    <name>A0A151PB96_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arfaptin-1 isoform D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARFIP1-1</name>
        <name evidence="9" type="ORF">Y1Q_0021832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PB96"/>
    <dbReference type="STRING" id="8496.A0A151PB96"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07660">
        <property type="entry name" value="BAR_Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000003">
        <property type="entry name" value="arfaptin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF4">
        <property type="entry name" value="ARFAPTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="8">
        <location>
            <begin position="251"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO46312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="471" mass="52882" checksum="3C97AF91AD57F876" modified="2016-06-08" version="1">MPLSHWYLKGKRIEGESDITTKQSSHKNYNSSPGFNRVLALTRKMNKVCLNVAMNSPHLMTLKQLQKRSSLTLRSVQWLKSLPKIRQRKFLYVLNKGIGKDKGLEQRGIGSGPLISAAQFTFQGGLNCTKDLKHSLPVGLGLSETKITSHSSDNTKEGVIEAGPFQGSSASPKSSVISPSSAAASRLAGQGCDLIIPTGGRMQQKSGPVVLADEVKNPAMEKLELVRKWSLNTYKCTRQIISERLGRGSRTVDLELEAQIEILRDNKKKYENILKLAQTLSTQLYQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLLTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQQLFQMHKEKYDKMRNDVSIKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PB97</accession>
    <name>A0A151PB97_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PB97"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11117" checksum="DE6A590C53ECB176" modified="2016-06-08" version="1">MEPSEPHHDKSAVSSTRIGVGSRGALQSVSSEEHMALHSAAWRKQWRYKFPRGTIGASYMKLEDSGMKKSLDPSLSRHHIPTLDAANVILRISPCQGILHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBG7</accession>
    <name>A0A151PBG7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beclin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BECN1</name>
        <name evidence="24" type="ORF">Y1Q_0018268</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endosome membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBG7"/>
    <dbReference type="STRING" id="8496.A0A151PBG7"/>
    <dbReference type="eggNOG" id="KOG2751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000001">
        <property type="entry name" value="beclin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029318">
        <property type="entry name" value="BH3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15285">
        <property type="entry name" value="BH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="14 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beclin-1 BH3" evidence="22">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="23">
        <location>
            <begin position="152"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="21">
        <location>
            <begin position="281"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="162"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF15285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO46457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="467" mass="53445" checksum="A4D726FA445FC2A7" modified="2016-06-08" version="1">MAGRGPAGAAFPAHAPSHGMEGSKLSACTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTVPAKPGDTHEEDATLAEEAFTENRQDGVSRRFVPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCLEILEQMNEEDKEKLQMELKELALEEEQLIQELEDVEKNRKIVAEDFKRVRAEAERLDQEEAQYQKEYCEFKRQQLELDDELKSVDNQMRYAQMQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYHLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETHFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PD26</accession>
    <name>A0A151PD26_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 18">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="3 18">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PLCD1</name>
        <name evidence="24" type="ORF">Y1Q_0014553</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="16">Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="3 18"/>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO47007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PD26"/>
    <dbReference type="STRING" id="8496.A0A151PD26"/>
    <dbReference type="GlyCosmos" id="A0A151PD26">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="102576343"/>
    <dbReference type="KEGG" id="amj:102576343"/>
    <dbReference type="CTD" id="5333"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13363">
        <property type="entry name" value="PH_PLC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08593">
        <property type="entry name" value="PI-PLCc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000071">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000088">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000098">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000022">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028391">
        <property type="entry name" value="PLC-delta1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF210">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 18" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="20">
        <location>
            <begin position="42"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="22">
        <location>
            <begin position="518"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="634"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="O-linked (GlcNAc) serine" evidence="17">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="O-linked (GlcNAc) threonine" evidence="17">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628391-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR628391-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR628391-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR628391-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO47007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="783" mass="90506" checksum="39E6CA710D706DD4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEH2</accession>
    <name>A0A151PEH2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phosphodiesterase</fullName>
            <ecNumber evidence="19">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PDE5A</name>
        <name evidence="21" type="ORF">Y1Q_0001224</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.1.4.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16958"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="19">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274105.1">
        <property type="nucleotide sequence ID" value="XM_006274043.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEH2"/>
    <dbReference type="STRING" id="8496.A0A151PEH2"/>
    <dbReference type="GeneID" id="102571895"/>
    <dbReference type="KEGG" id="amj:102571895"/>
    <dbReference type="CTD" id="8654"/>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74705at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PEH2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000004">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000015">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5" id="KW-0140">cGMP</keyword>
    <keyword evidence="12" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="10 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDEase" evidence="20">
        <location>
            <begin position="511"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="588"/>
            <end position="592"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="792"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO47428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="850" mass="96971" checksum="74DAAE6257F5A557" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEQ2</accession>
    <name>A0A151PEQ2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Prosaposin receptor GPR37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GPR37</name>
        <name evidence="17" type="ORF">Y1Q_0019645</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEQ2"/>
    <dbReference type="STRING" id="8496.A0A151PEQ2"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151PEQ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036505">
        <property type="term" value="F:prosaposin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15127">
        <property type="entry name" value="7tmA_GPR37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000059">
        <property type="entry name" value="G protein-coupled receptor 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003909">
        <property type="entry name" value="GPR37_orph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46216:SF3">
        <property type="entry name" value="PROSAPOSIN RECEPTOR GPR37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46216">
        <property type="entry name" value="PROSAPOSIN RECEPTOR GPR37 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01421">
        <property type="entry name" value="GPR37ORPHANR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="14"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO47518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="349" mass="39366" checksum="12E2774D3A785F70" modified="2016-06-08" version="1">MCLSVVIFGTGILGNMAVMCIVCHNYYMRSISNSLLANLAFWDFLVLFFCLPLVIFQELTKKWLLEDFSCKVVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCTSTTAKLAVIWVGALLLALPEVVLRQLTKEDPEFSGSLPGERCVVKISTELPDTIYVLALTYDGARLWWYFGCYFCLPTLFTITCSLVTARKIRRAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMSTGVSQQTMDLLHLISQFLLFFKSCVTPVVLFCLCKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFI7</accession>
    <name>A0A151PFI7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWWP domain-containing protein MUM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MUM1</name>
        <name evidence="3" type="ORF">Y1Q_0005845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PWWP3A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000375">
        <property type="protein sequence ID" value="KYO47867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFI7"/>
    <dbReference type="STRING" id="8496.A0A151PFI7"/>
    <dbReference type="eggNOG" id="ENOG502QPRU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06080">
        <property type="entry name" value="PWWP_MUM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000063">
        <property type="entry name" value="PWWP domain-containing DNA repair factor 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035504">
        <property type="entry name" value="MUM1-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040263">
        <property type="entry name" value="PWP3A_3B_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048795">
        <property type="entry name" value="PWP3A_3B_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048765">
        <property type="entry name" value="PWP3A_3B_4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31333:SF6">
        <property type="entry name" value="MUM1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31333">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20884">
        <property type="entry name" value="MUM1-like_PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20886">
        <property type="entry name" value="PWP3A-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20887">
        <property type="entry name" value="PWP3A-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO47867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="548" mass="63456" checksum="4F979939B93DFB57" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFR8</accession>
    <name>A0A151PFR8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lin-7-like protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LIN7A</name>
        <name evidence="12" type="ORF">Y1Q_0019875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFR8"/>
    <dbReference type="STRING" id="8496.A0A151PFR8"/>
    <dbReference type="eggNOG" id="KOG3550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000298">
        <property type="entry name" value="Protein lin-7 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017365">
        <property type="entry name" value="LIN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038039">
        <property type="entry name" value="Lin-7_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="L27" evidence="11">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="95"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO47832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="160" mass="17382" checksum="62BC61A1B2353DFE" modified="2016-06-08" version="1">MATLTAVQPLSLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGFSLNVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHW9</accession>
    <name>A0A151PHW9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Occludin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">OCLN</name>
        <name evidence="6" type="ORF">Y1Q_0004033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ELL/occludin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHW9"/>
    <dbReference type="STRING" id="8496.A0A151PHW9"/>
    <dbReference type="eggNOG" id="ENOG502QS9F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF4">
        <property type="entry name" value="OCCLUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="OCEL" evidence="5">
        <location>
            <begin position="287"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="302"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO48630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="395" mass="46140" checksum="3C68BBE90C4215F7" modified="2016-06-08" version="1">MMGVSQLISCITGAQEILFYYCQGNLLCKWLCTSGLLLSQEVRGSRGKSRAQAFGALRYQKYILEFSSPALQLCCPDLLEILHLIDQNSNFLVVHKITIHVMRNGAVNQRIYVYLYWYHYCILDIEEIISIVLVCLIILGLIAIIILALITRNRIHCCGKRNIMWYRRQVCEPAPKIQEWPKNTKTGCSEIVPVLDCQDQLPTSMTHPVYSKANECKGYTDNTYKYSQDHFELIKDVKPSDYFSKTTYIGSTKRLSQKIRAERPNIDNYDMDYTTAGESCDELDIKEEWDREYPPVTSDEQRQAYKRDFDAELQEYRGLQAELEEIKEELRYLDKELDEYNEDTEEYKAAADEYNRLKDIKASADYTNKKAQFKKLKNKLSHIKKMVNDYDNQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIG7</accession>
    <name>A0A151PIG7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000178">
        <property type="protein sequence ID" value="KYO48849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIG7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="9626" checksum="65E147E6C383685A" modified="2016-06-08" version="1">MQSPGQSHDPLPVHTPAQSMQAADIGSALARDHAVTATRSQPGPRAASHPAKCPASAAAAGLQETLAPGYHSAAAAGVSMETGPSHAETETGPSTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIP0</accession>
    <name>A0A151PIP0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylacetamide deacetylase-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0001147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000161">
        <property type="protein sequence ID" value="KYO48966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIP0"/>
    <dbReference type="STRING" id="8496.A0A151PIP0"/>
    <dbReference type="ESTHER" id="allmi-a0a151pip0">
        <property type="family name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF32">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="78"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="248"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO48966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="349" mass="39470" checksum="3636CA8AFEABBD31" modified="2016-06-08" version="1">MSVLFSLELILEKLGIYVDHHIIRFLLNLTPSGDTSKLFIKDLTFEKMKVRIYQPKVPSAGLRRGVVYCHGGTGRFGSITTKTESVVMCVGYRLAPEHPFPAQFDDCLAATIHFMRTAEDYGVDPTRIIVCGDSSGGTIATAVCQALVDRTDLPKVRAQMVIYPFLQAVDFNLPSYQQNHTMPPLLRKWTIHLGLRYLNIDVSVVDGILKGIHIREDLREKYSKWLSPDNIQNEFKIRGYEPPKLYPCVEEYCIKAQAFLTPTFSPLLAEDDVIRQLPETFILTCEYDVLRDDGLLYKKRLEDNGVQVTWCHLKDGFHGVVAIAKMYGIISFEAGLTGINAMAKFIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIQ2</accession>
    <name>A0A151PIQ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DENN domain-containing protein 4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0000784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000146">
        <property type="protein sequence ID" value="KYO48977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIQ2"/>
    <dbReference type="eggNOG" id="KOG2127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF18">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO48977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="79537" checksum="BCDDA7A88DB7BDA7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJU6</accession>
    <name>A0A151PJU6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0018807</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000117">
        <property type="protein sequence ID" value="KYO49035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJU6"/>
    <dbReference type="STRING" id="8496.A0A151PJU6"/>
    <dbReference type="KEGG" id="amj:102577146"/>
    <dbReference type="eggNOG" id="ENOG502QUKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5960253at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PJU6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010876">
        <property type="entry name" value="C1orf43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425:SF2">
        <property type="entry name" value="PROTEIN C1ORF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07406">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO49035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="255" mass="28807" checksum="AB13EEB7DCB542A4" modified="2016-06-08" version="1">MAATGSNWLSGVNVVLVMAYSSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGQHAPKDLKEEIDVRLSRVQDIKYEPQLLAEDDARLLQLETSGSQCCYNYLYRMKALDAIRTSDIPFYADGRYPKALIGKSFRAYLLELRNSSTPFKGIRKTLVDTLLDGYDSARYGTGVFGKTEYLKYQEALTELANIIKARGGSSQRQHQSAAKDLTLSPEVSNPATIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYM0</accession>
    <name>A0A151LYM0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calmodulin-binding transcription activator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Y1Q_0011833</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Transcriptional activator.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">May interact with calmodulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Endomembrane system</location>
            <topology evidence="18">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAMTA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007022">
        <property type="protein sequence ID" value="KYO17343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151LYM0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000038">
        <property type="entry name" value="calmodulin-binding transcription activator 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000165">
        <property type="entry name" value="calmodulin-binding transcription activator 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000089">
        <property type="entry name" value="calmodulin-binding transcription activator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000013">
        <property type="entry name" value="Vesicle-associated membrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF11">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="11 21" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1602"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="21">
        <location>
            <begin position="913"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="25">
        <location>
            <begin position="1538"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="134"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
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            <begin position="387"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="846"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1054"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1510"/>
            <end position="1543"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="217"/>
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            <begin position="400"/>
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            <begin position="443"/>
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            <end position="1535"/>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00055757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071877"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO17343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1633" mass="179298" checksum="D53B7C608BD52DBA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZH7</accession>
    <name>A0A151LZH7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Olfactory receptor 6M1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0005875</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF51">
        <property type="entry name" value="OLFACTORY RECEPTOR 6M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="231" mass="25791" checksum="87C1308C8F022D5C" modified="2016-06-08" version="1">MLSSLLAQKKSISFAGCITQTYFYFFLGTVEFILLAVMSFDRYVAICNPLRYTVIMNSSICFLMVLGCWVGAFLSVLCPTIVVSRLPYCGHAINHFFCDIAPLLQVACIDTRLIELLNFLLSSLVVLSSLMLTAVSYSYIISTIMKIPSGQGRQKAFSTCVSHITVVTIAYGSSIFMYVRPNQSYSLEFDKVAAVLTTVVTPLLNPFIYSLRNEKVKEVLKEAVIRIFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M084</accession>
    <name>A0A151M084_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium channel protein type 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0011559</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M084"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Voltage-dependent sodium channel"/>
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        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Na_chnl_inactivation_gate"/>
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    <dbReference type="InterPro" id="IPR027359">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
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        <property type="match status" value="5"/>
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    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="125"/>
            <end position="148"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1238"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1277"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1354"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1478"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1561"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1591"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1616"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="128"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="237"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-gated Na+ ion channel cytoplasmic" evidence="15">
        <location>
            <begin position="586"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="788"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium ion transport-associated" evidence="14">
        <location>
            <begin position="1026"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="1236"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="1560"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="domain" description="SCN5A-like C-terminal IQ motif" evidence="16">
        <location>
            <begin position="1703"/>
            <end position="1734"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="62"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="518"/>
            <end position="557"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="615"/>
            <end position="661"/>
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            <end position="1193"/>
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            <begin position="1748"/>
            <end position="1805"/>
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        <location>
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            <end position="497"/>
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        <location>
            <begin position="28"/>
            <end position="41"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="557"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="624"/>
            <end position="638"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1193"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF11933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO17918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1805" mass="205433" checksum="9A8D2F76B96BA7AB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0C3</accession>
    <name>A0A151M0C3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Secretory phospholipase A2 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PLA2R1</name>
        <name evidence="11" type="ORF">Y1Q_0011582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000032">
        <property type="entry name" value="Secretory phospholipase A2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000034">
        <property type="entry name" value="secretory phospholipase A2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000038">
        <property type="entry name" value="Secretory phospholipase A2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
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        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
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    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type-II" evidence="10">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="95"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="240"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="380"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="535"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="677"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="825"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="979"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="1115"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO17953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1303" mass="151883" checksum="A7ABA0EBBC02E419" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0D2</accession>
    <name>A0A151M0D2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dipeptidyl peptidase 4</fullName>
            <ecNumber evidence="9">3.4.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Dipeptidyl peptidase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">T-cell activation antigen CD26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">Y1Q_0011573</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Apical cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Invadopodium membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Lamellipodium membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glucagon family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S9B family. DPPIV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="9"/>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0D2"/>
    <dbReference type="STRING" id="8496.A0A151M0D2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031258">
        <property type="term" value="C:lamellipodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.590">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000532">
        <property type="entry name" value="Glucagon_GIP_secretin_VIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF128">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00123">
        <property type="entry name" value="Hormone_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00275">
        <property type="entry name" value="GLUCAGON"/>
    </dbReference>
    <dbReference type="SMART" id="SM00070">
        <property type="entry name" value="GLUCA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00260">
        <property type="entry name" value="GLUCAGON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="18" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="19" id="KW-0965">Cell junction</keyword>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="25" id="KW-0966">Cell projection</keyword>
    <keyword evidence="23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="24" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0964">Secreted</keyword>
    <keyword evidence="17" id="KW-0720">Serine protease</keyword>
    <keyword evidence="20" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="15 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21 29" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Glucagon / GIP / secretin / VIP family" evidence="30">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Glucagon / GIP / secretin / VIP family" evidence="30">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00010036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00014711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00030567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00031284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KYO17940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="992" mass="113584" checksum="3F2612835C6A6590" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0M4</accession>
    <name>A0A151M0M4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyl-CpG-binding domain protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methyl-CpG-binding protein MBD5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MBD5-1</name>
        <name evidence="13" type="ORF">Y1Q_0011634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Core component of the polycomb repressive deubiquitinase (PR-DUB) complex, at least composed of BAP1, one of ASXL1, ASXL2 or (probably) ASXL3, and one of MBD5 or MBD6. Distinct combinations of ASXL and MBD proteins may preferentially bind specific histone modification marks. The PR-DUB core associates with a number of accessory proteins, including FOXK1, FOXK2, KDM1B, HCFC1 and OGT; KDM1B specifically associates with ASXL2 PR-DUB complexes. Interacts (via MBD domain) with ASXL1, ASXL2 and ASXL3 (via PHD domain); the interaction is probably direct, mediates association with other PR-DUB complex core components.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0M4"/>
    <dbReference type="STRING" id="8496.A0A151M0M4"/>
    <dbReference type="eggNOG" id="ENOG502QTC7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20141">
        <property type="entry name" value="PWWP_MBD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000035">
        <property type="entry name" value="Methyl-CpG binding domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, DROSOPHILA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112:SF18">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MBD" evidence="12">
        <location>
            <begin position="61"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="11">
        <location>
            <begin position="863"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="829"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="974"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO18032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="985" mass="105180" checksum="CD54198C9AF259F0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M133</accession>
    <name>A0A151M133_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M133"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="127" mass="13989" checksum="7BCB99E87F7B069E" modified="2016-06-08" version="1">MAHSCSKAKKGMCLTFQVHQRKDLAHENSISPWGVCSCKPHFVHQRVRCTVTRAATFSQVCVTSSEKGLPLTIHCTGSDTARSLLIQADKPICPALGHCIMIEKYCDTDTPFPCPLHPPVTELRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1K4</accession>
    <name>A0A151M1K4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aldose 1-epimerase</fullName>
            <ecNumber evidence="13">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GALM</name>
        <name evidence="17" type="ORF">Y1Q_0008515</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266227.1">
        <property type="nucleotide sequence ID" value="XM_006266165.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1K4"/>
    <dbReference type="STRING" id="8496.A0A151M1K4"/>
    <dbReference type="GeneID" id="102560691"/>
    <dbReference type="KEGG" id="amj:102560691"/>
    <dbReference type="CTD" id="130589"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M1K4"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000003">
        <property type="entry name" value="Aldose 1-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008277">
        <property type="entry name" value="PRK11055.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO18397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="341" mass="37595" checksum="529C4CB8312440FF" modified="2016-06-08" version="1">MAGVQRELLGHVGEEGAVEKFVLKSDKVKVELLSLGCIITALETRGRDGQASDIVVGFDHLQGYVNKHPYFGAVIGRVANRIAKGKFILEGKEYQLAINNKPNSLHGGTKGFDKVLWTPEVLPNGVCFFRISPDGEEGYPGKLKVWVTYTLDGGELAINYRAQASKTTLVNLTNHAYFNLAGQGSRDIYDHEVSIEADSYLPVDDNHIPTGEVAAVQGTGFDLRQSVEVGNHLKKFQLDGFDHNFCLKQSAARQFCARVHHPRSGRTLEVYTTQPGVQFYTGNALDGSLTGKGGATYPKHSAFCLETQNWPDAVNKPHFPDVLLRPGEEYNHTTWFRFSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M346</accession>
    <name>A0A151M346_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M346"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="217" mass="24826" checksum="51A8002E2F27F2B1" modified="2016-06-08" version="1">MERVAITMPTGRTVMLTGDFNCVIAEEDRVSGNKGTGMDRSSKQLGQLVCDHGLVDAVKKAQGPGGHFTQVDPAGNTKSRIDFVFLPTGWKAEEAKCTPVCFSDHSLLTLRIDLGGQLERGRGVWKLNTSLLEDEQTRRSYREHYAGWWTLRELYQNQTEWWASVKERTRSFFQTVGKGWALFHQRRHKCLTCKLQDLHRQAVVEQDVREAMWELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3E2</accession>
    <name>A0A151M3E2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MutS protein homolog 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MSH5</name>
        <name evidence="12" type="ORF">Y1Q_0018958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3E2"/>
    <dbReference type="STRING" id="8496.A0A151M3E2"/>
    <dbReference type="GeneID" id="102571072"/>
    <dbReference type="KEGG" id="amj:102571072"/>
    <dbReference type="CTD" id="4439"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000008">
        <property type="entry name" value="MutS homolog 5 (E. coli)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000820">
        <property type="entry name" value="MutS homolog 5 (E. coli)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO19006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="813" mass="91887" checksum="74B956B2F63D7473" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3P8</accession>
    <name>A0A151M3P8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OR4N2</name>
        <name evidence="12" type="ORF">Y1Q_0005034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006740">
        <property type="protein sequence ID" value="KYO19137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3P8"/>
    <dbReference type="STRING" id="8496.A0A151M3P8"/>
    <dbReference type="GeneID" id="102569860"/>
    <dbReference type="KEGG" id="amj:102569860"/>
    <dbReference type="OrthoDB" id="6130476at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15937">
        <property type="entry name" value="7tmA_OR4N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO19137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="319" mass="36376" checksum="44275B00DC7E3615" modified="2016-06-08" version="1">MQRLHADGMEQGNGTEVVEFVLLGLAQTQEVQFFLFILFLIFYSLVLPANILIILTIQRDRRLGSPMYFFLANLAFLDICYCSITPPRMLVDFFSQHKAISYRACMAQLFFLHFLGGAEIFLLISMAFDRYVAICKPLHYTTVVNRGVCWALVVAAWTGGFTHSIIQVILIIRLPFCGPNQLDNFFCDVTQVIELACTDTYQLEFVIFINNSLVILVSFFLLLISYGALLVRLRAGSSLGKSKAASTCVTHIIIVFVMFSPAIYIYCRPFCSFPMDKVVAVFHTVVFPLVNPMIYTLRNREILSAMNRLMHKHKLWRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3W1</accession>
    <name>A0A151M3W1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Repressor of the inhibitor of the protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRKRIR</name>
        <name evidence="8" type="ORF">Y1Q_0001116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006672">
        <property type="protein sequence ID" value="KYO19204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3W1"/>
    <dbReference type="STRING" id="8496.A0A151M3W1"/>
    <dbReference type="GeneID" id="102576745"/>
    <dbReference type="KEGG" id="amj:102576745"/>
    <dbReference type="CTD" id="5612"/>
    <dbReference type="eggNOG" id="ENOG502QU3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7683421at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M3W1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF16">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_THAP"/>
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    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="153"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO19204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="767" mass="87943" checksum="30E981E0B0F36801" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
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                <person name="Sawyer R.H."/>
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                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
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                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37858">
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        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="147" mass="16154" checksum="C7EA267983A0B82D" modified="2016-06-08" version="1">MEKNLSKSSWCALNKGRRKRSANGESVKVPVEFLSHLSSVLVAGATIVGIVIFALGLAVFCLFYKRRKICQFLGSIAEDEELPNGFVSTDAQYYKPVSLSQYFHAGKLQEASKNQAAAATAPDVCTTDSEPEKTWNIVFISVQDTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4W0</accession>
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        <name type="common">American alligator</name>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
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                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
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            </authorList>
            <dbReference type="PubMed" id="22293439"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006584">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="8496.A0A151M4W0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11495" checksum="A2D8927E165263B4" modified="2016-06-08" version="1">MLGKFLSKFHNLELSLPLFKIKVAAIFLGLQMLDNSPNQWMIGTMGGFVGWEALIHIMFEGLHKQVKFEDSHGEIKSEIIIFLTFVCGNLAFLVALLVGIAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5A8</accession>
    <name>A0A151M5A8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RIIa domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RIIAD1</name>
        <name evidence="2" type="ORF">Y1Q_0012351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006582">
        <property type="protein sequence ID" value="KYO19703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014453260.1">
        <property type="nucleotide sequence ID" value="XM_014597774.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5A8"/>
    <dbReference type="STRING" id="8496.A0A151M5A8"/>
    <dbReference type="GeneID" id="106737650"/>
    <dbReference type="KEGG" id="amj:106737650"/>
    <dbReference type="CTD" id="284485"/>
    <dbReference type="OrthoDB" id="10249338at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22971">
        <property type="entry name" value="DD_RIIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059162">
        <property type="entry name" value="RIIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505:SF4">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="11261" checksum="B73CA7CE2B9F58D0" modified="2016-06-08" version="1">MADVGSGLEGPDLGALSPEQQARLLELKISTRIANERYLRDHREVELLLSGFVREVLLRRPENIPEFAAEHFTDPELPMKIQKQLMEKVNATERPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6E6</accession>
    <name>A0A151M6E6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Docking protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DOK3</name>
        <name evidence="3" type="ORF">Y1Q_0016263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006450">
        <property type="protein sequence ID" value="KYO20000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6E6"/>
    <dbReference type="STRING" id="8496.A0A151M6E6"/>
    <dbReference type="eggNOG" id="KOG4047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF42">
        <property type="entry name" value="DOCKING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="147"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO20000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="451" mass="48885" checksum="94B965A74B3D89C5" modified="2016-06-08" version="1">MEGPVKDGILYVQHFKFGKRSWKKVRAQLFAAGPSGVARMEQFAVRDGSGPEKTSLRRGERRVLRLADCVSVGPAGSEGCPRGTAAFCLRTLDKSHVLAAEQPDEWVAQLCQLAFQGTKEMAPGSNRASPSSGLHMEENTIYSSWHAPNEFPVLLLRTEASTRCGLSGRYLLAVLPERLVLKELQTRQPLLAWPYPFLRKFGQDQAMLSFEAGRRCDSGEGVFTFSTGRAAEICGLISAAIARQRNQEPWQHPASSPEGAPSASWALEDGGATPPAWLRPEHPPPQPCSREPGAPDRVDHTFPVIYASIARGPQPLPAAVRREPEPEAWGQQPSEHLYENLCGPEPDCPGRGLDQAAASWHRSCREPPEGSSGPEAPIYDNSCMVAAARSGAPSPVLQPRYQRLQDPEGPDSAAHGEATASNGLRRRLVTLLSREAAPPVPGRTPSPADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7C7</accession>
    <name>A0A151M7C7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0005887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006405">
        <property type="protein sequence ID" value="KYO20433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7C7"/>
    <dbReference type="KEGG" id="amj:109280860"/>
    <dbReference type="OrthoDB" id="10360984at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584820" evidence="3">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO20433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="214" mass="22912" checksum="A5727AE54679ABA9" modified="2016-06-08" version="1">MEPRGRRIWQVCIAVLCAGAVTRAEVKASPPNTGQVQHMPELEGDFNGTTKETARNTTWIPTTLAGPTEGSTAAYTVNRGDTTADNAEVSSSISPKYWSPVIFVVLALIVLFFTYRRKRGRGTSSRAASMAESSDSDMPIVPDPDRHRVSHQEKRPSFPGKQGPTNTGTPVAETSPSPEMMESVFCEPGSSSYQAAVSITAEVSDSCPRTSGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8A8</accession>
    <name>A0A151M8A8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8A8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9681" checksum="771E1CB6277D5415" modified="2016-06-08" version="1">MELGPAAYSLERQQSESMEKRERHQSSHCGYFQDCMIKEEIFKVLVKEDIVEKIEAEGLAENWTSDAILLEATKLLEHIPISKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAC7</accession>
    <name>A0A151MAC7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding protein with multiple splicing 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RBPMS2</name>
        <name evidence="8" type="ORF">Y1Q_0001668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAC7"/>
    <dbReference type="STRING" id="8496.A0A151MAC7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12683">
        <property type="entry name" value="RRM_RBPMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000037">
        <property type="entry name" value="RNA-binding protein with multiple splicing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034787">
        <property type="entry name" value="RBPMS2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO21468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="274" mass="29969" checksum="6F38751C013C1903" modified="2016-06-08" version="1">MSSLNKEGEHSNSTTNIEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVTFDSRAGAEAAKNALNGIRFDPENPQTLRLEFAKANTKMAKSKLMATPNPTNIHPALGAHFIARDPYDLTGAALIPASPEAWAPYPLYTTELTPAIPHAAFTYPAAAAAAAALHAQLVEWLYYSSIPRSVKHDGTHVWKDWTVSRISGFHVVRKPQKKTASYSWTDRCAGILPLKLPSKDGSLVSFVSSSSLFLACILPFLSLHGVMCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB50</accession>
    <name>A0A151MB50_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 229B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM229B</name>
        <name evidence="7" type="ORF">Y1Q_0000421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM229 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MB50"/>
    <dbReference type="eggNOG" id="ENOG502QTFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31746">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 229 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31746:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 229B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO21699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="193" mass="22512" checksum="9FDE3A176A1E09BC" modified="2016-06-08" version="1">MSSLAQGNKSNSLVLDFEFLLRLCGRMAAAEPLTAFSRWYLYAIHGYFCEVMFTAAWEFVVNFNWKFPGVTSVWALFIYGTSILIVEKMYLYLKDKCNIIVRCLIYTLWTYFWEFTTGFILRQFNACPWDYSQFDFDFMGLITLEYAIPWFCAAFIMEQLVIRNTLRLRFDENAEPGAPTATVTLANGHVKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBF7</accession>
    <name>A0A151MBF7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Exostosin-2</fullName>
            <ecNumber evidence="5">2.4.1.224</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">EXT2</name>
        <name evidence="27" type="ORF">Y1Q_0000496</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1-&gt;4)-beta-D-GlcA and (1-&gt;4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-O-{[(1-&gt;4)-beta-D-GlcA-(1-&gt;4)-alpha-D-GlcNAc](n)-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1-&gt;4)-beta-D-GlcA-(1-&gt;4)-alpha-D-GlcNAc](n)-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl}-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16213"/>
            <dbReference type="Rhea" id="RHEA-COMP:12621"/>
            <dbReference type="Rhea" id="RHEA-COMP:12623"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132415"/>
            <dbReference type="ChEBI" id="CHEBI:132416"/>
            <dbReference type="EC" id="2.4.1.224"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:16214"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Part of the heparan sulfate polymerase, a dimeric complex composed of EXT1 and EXT2. Could also form homooligomeric complexes. Interacts with NDST1. Interacts with GALNT5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Golgi apparatus</location>
            <location evidence="18">cis-Golgi network membrane</location>
            <topology evidence="18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.224" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBF7"/>
    <dbReference type="STRING" id="8496.A0A151MBF7"/>
    <dbReference type="eggNOG" id="KOG1022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050508">
        <property type="term" value="F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000035">
        <property type="entry name" value="Putative Exostosin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF5">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="25">
        <location>
            <begin position="84"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="26">
        <location>
            <begin position="439"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00053270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO21809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="701" mass="80630" checksum="D25F98E28D8105A1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBZ7</accession>
    <name>A0A151MBZ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0000677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBZ7"/>
    <dbReference type="STRING" id="8496.A0A151MBZ7"/>
    <dbReference type="KEGG" id="amj:106736988"/>
    <dbReference type="eggNOG" id="KOG3569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266080at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.200:FF:000001">
        <property type="entry name" value="DENN domain-containing protein 2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000004">
        <property type="entry name" value="DENN domain-containing protein 2C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF5">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="683"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO22056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1122" mass="126882" checksum="2A4160EFBBE1E321" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC63</accession>
    <name>A0A151MC63_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MC63"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10338" checksum="FC27F9C27BA7BC4A" modified="2016-06-08" version="1">MDINGSSSRPENHSKCGIFPPEKFVKPLTIDLSHDFQFPVCDIISGCCGDYYEDRNRGILLIFVRGGTAFSMYLTCQTQGQRFRDSHVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCS7</accession>
    <name>A0A151MCS7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCS7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="117" mass="13106" checksum="5FEA223D10308B47" modified="2016-06-08" version="1">MMAVLCRYRLLFGMSLEHSGCFRQPIRVLQAGCDVLGHRQGVVGLKQHIYGEILTETVEIKYKSSFFLSFFYHSLFVAPANENLNSLALQVPKLVLSFDAGHSCLHLGLQECTSLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCW7</accession>
    <name>A0A151MCW7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Spire-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SPIRE1L</name>
        <name evidence="16" type="ORF">Y1Q_0002967</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spire family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCW7"/>
    <dbReference type="STRING" id="8496.A0A151MCW7"/>
    <dbReference type="eggNOG" id="ENOG502R9W2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15748">
        <property type="entry name" value="FYVE_SPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF9">
        <property type="entry name" value="KIND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KIND" evidence="15">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO22377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="596" mass="67690" checksum="5E7B1A3473B54686" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF27</accession>
    <name>A0A151MF27_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Prostaglandin-H2 D-isomerase</fullName>
            <ecNumber evidence="27">5.3.99.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Glutathione-independent PGD synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Lipocalin-type prostaglandin-D synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Prostaglandin-D2 synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">PTGDS</name>
        <name evidence="35" type="ORF">Y1Q_0005558</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>prostaglandin H2 = prostaglandin D2</text>
            <dbReference type="Rhea" id="RHEA:10600"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57406"/>
            <dbReference type="EC" id="5.3.99.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 32">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.2" evidence="27"/>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF27"/>
    <dbReference type="STRING" id="8496.A0A151MF27"/>
    <dbReference type="GeneID" id="102565053"/>
    <dbReference type="KEGG" id="amj:102565053"/>
    <dbReference type="eggNOG" id="ENOG502S6GK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9048943at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MF27"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004667">
        <property type="term" value="F:prostaglandin-D synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043303">
        <property type="term" value="P:mast cell degranulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19419">
        <property type="entry name" value="lipocalin_L-PGDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002345">
        <property type="entry name" value="Lipocalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430:SF86">
        <property type="entry name" value="PROSTAGLANDIN-H2 D-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00179">
        <property type="entry name" value="LIPOCALIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01254">
        <property type="entry name" value="PGNDSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="22" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="23" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="24" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0467">Mast cell degranulation</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="10" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0964">Secreted</keyword>
    <keyword evidence="15 33" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="33">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585098" description="Prostaglandin-H2 D-isomerase" evidence="33">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="34">
        <location>
            <begin position="35"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00030654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00031917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00032350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="RuleBase" id="RU003695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KYO23099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="185" mass="20981" checksum="1A5218B399A575E0" modified="2016-06-08" version="1">MQAALLSILGLALIGSLCAQEDVPVQPDFQPEKFTGKWYSIGLASNAKWFQDKKALMKMCTTVIESTPEGNLDVTSTYPKSDRCEKRNSLYIKTDQPGRFSYTSQRWGSQHDIRVVETNYDEYALVYTKKVKDTNTFTMVLLYGRTKELSPERLEKFTQFSKGQGLPEDAILILPKSDQCMEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFW0</accession>
    <name>A0A151MFW0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNL-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DNLZ</name>
        <name evidence="7" type="ORF">Y1Q_0005785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFW0"/>
    <dbReference type="STRING" id="8496.A0A151MFW0"/>
    <dbReference type="eggNOG" id="KOG3277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO23412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="265" mass="28141" checksum="09D19CAEF84326BD" modified="2016-06-08" version="1">MAAAAPSRGVVARYRLVYTCQVCKTRSAKTISKVAYHQGVVIVTCPGCQNHHVIADNLGWFTDLEGKRNIEEILAAKGEKSCKEGWQEDAGCCRAWIGDPPSSSSILHRSPAGGTSPRGASTFSHGRCMEVFEVQPKLALGCPQTLLQDGMPWPADTGSRSATEGGGTAASCEPAGRKQHDQPLRRGRVLASAADKSGACRSGWTFKSELPAWAGPEGLKRSRDLNPPAAARTRPALCVRSPGLEKETPCALQTALGRQKGDGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGE6</accession>
    <name>A0A151MGE6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGE6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7742" checksum="84A5A030F192086F" modified="2016-06-08" version="1">MYKQYLRTAFYTGIFGFEEPAESCDTHQLCFWSSVRTASEFSLKKRILQMSWSTEDFPLTTETAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHZ7</accession>
    <name>A0A151MHZ7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO24010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHZ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8543" checksum="43AEC3C64B64F370" modified="2016-06-08" version="1">MHCMGLIYLETSVLQCRFTRSQVTALPVPYCPGHTQLCYGLSFCSSLFKISVGEGVTALVSWGSNIWELMYFWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKV7</accession>
    <name>A0A151MKV7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Matrix metalloproteinase-28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MMP28</name>
        <name evidence="13" type="ORF">Y1Q_0002592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005942">
        <property type="protein sequence ID" value="KYO25089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKV7"/>
    <dbReference type="STRING" id="8496.A0A151MKV7"/>
    <dbReference type="eggNOG" id="KOG1565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:collagen catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.390.10:FF:000021">
        <property type="entry name" value="Matrix metallopeptidase 28"/>
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    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
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        <property type="entry name" value="M10A_MMP"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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        <property type="entry name" value="Pept_M10_metallopeptidase"/>
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        <property type="entry name" value="Peptidase_Metallo"/>
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        <property type="entry name" value="MATRIX METALLOPROTEINASE-28"/>
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    <feature type="domain" description="Peptidase metallopeptidase" evidence="12">
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            <begin position="74"/>
            <end position="232"/>
        </location>
    </feature>
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            <begin position="272"/>
            <end position="316"/>
        </location>
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            <begin position="317"/>
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            <position position="39"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <position position="127"/>
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        <ligand>
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        <ligand>
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            <position position="166"/>
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            <position position="169"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <position position="187"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <position position="191"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <name>Zn(2+)</name>
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            <position position="276"/>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
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        <ligand>
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        <location>
            <position position="321"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <position position="323"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <name>Ca(2+)</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
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            <dbReference type="ARBA" id="ARBA00022670"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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            <dbReference type="ARBA" id="ARBA00022837"/>
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            <dbReference type="ARBA" id="ARBA00023049"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00235"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO25089.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
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    </evidence>
    <sequence length="426" mass="48586" checksum="786325018B67DA20" modified="2016-06-08" version="1">MHSPAQFRAAVREFQWVTHLPVSGVLDASTVHQMSLPRCGVNDAESHTAWAKRVHAVFSGRRAKARRRRRFAQQSGKWYKRHLSYRIVNWPWYLPQHQVQLAVKAAFELWSNVSSLVFWEAQDGPADIRLTFFHGDHNDGLGNAFDGPGGALAHAFFPRRGEAHFDSDERWSLHSSKGRNLFIVAAHEIGHTLGLEHSPVKSALMSPYYKKLSKDFVLSWDDILAVQNLYGKPSKGSAVQLPGKVFAHFQDWSRTFPGGTQQQGRHVSYYCHSFFDAITVDADHNLYIFKGNHYWLVSKRGNATEPQPLQTRWAGLPAGIDAATWSEADGKFYFFKGGRCWRYKGSTMEAGFPQKCSASNLPRHPNAALYFQQLHHLVLFKGPKYYVDDQYWKFDQGKLQVVMTGKWATQLPWMGCWDVNSSQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLP4</accession>
    <name>A0A151MLP4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">USP36</name>
        <name evidence="2" type="ORF">Y1Q_0019920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005792">
        <property type="protein sequence ID" value="KYO25445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="586" mass="62427" checksum="79D3A945A5F1263A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN57</accession>
    <name>A0A151MN57_ALLMI</name>
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        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">Y1Q_0018528</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03005665">
        <property type="protein sequence ID" value="KYO25869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN57"/>
    <dbReference type="STRING" id="8496.A0A151MN57"/>
    <dbReference type="eggNOG" id="KOG0196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09488">
        <property type="entry name" value="SAM_EPH-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000059">
        <property type="entry name" value="Ephrin type-A receptor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000071">
        <property type="entry name" value="Ephrin type-B receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000268">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF19">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 24" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012655786" description="receptor protein-tyrosine kinase" evidence="24">
        <location>
            <begin position="16"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="28">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="243"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="352"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="534"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="26">
        <location>
            <begin position="833"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="540"/>
            <end position="548"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="62"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KYO25869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="907" mass="97347" checksum="656B5C118371A327" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNF1</accession>
    <name>A0A151MNF1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">XKR9</name>
        <name evidence="8" type="ORF">Y1Q_0003759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNF1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF13">
        <property type="entry name" value="XK-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO25983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="143" mass="16288" checksum="239E9FA9D3AD5A17" modified="2016-06-08" version="1">MPNSLVQTFSFEWFKDDFERPELGKLAWTFLVHSLHGGILIRYYFALKCGFQSAFKQSSCEDKLSGSPTGDIHKQAIDAVTDISMLRVFKIFLETTPQLLLQIHILMEEDKTSFIQCNSLSLLSIFLSLHLSAVFPGQLLTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNS4</accession>
    <name>A0A151MNS4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase p58-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0002005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005656">
        <property type="protein sequence ID" value="KYO26197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNS4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase p58-like C-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO26197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="119" mass="14048" checksum="6ED24A4C28521142" modified="2016-06-08" version="1">MGLGVSAEEYRRDLQDRIQKAQRIARHNVREAQERQETHYNRRARPRTFQPGDQVLVLIPATSSKQLAMWQGPFTFIRQVGSVDYEVRKPGHRREQQQHVNRLKEWKTPSSMDGPREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPY7</accession>
    <name>A0A151MPY7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha-2,8-sialyltransferase 8F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ST8SIA6</name>
        <name evidence="12" type="ORF">Y1Q_0019090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPY7"/>
    <dbReference type="eggNOG" id="KOG2692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF29">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE 8F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO26598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="321" mass="35684" checksum="733BC8B47E868F3F" modified="2016-06-08" version="1">MRAVIALVALLGSLLLFVCLLWLTADGSLRARSWEKEAAAGTAGTPQARRKLRSPLASAQPGPGSQNRTAHNKNGIYSHDQALKCKEIQDNILSSSVKKKRYSENYYLQIVTKLQHCAWKRRPEEYEKFRSELASCCDAAHNFIVSQNNTPLGSNLSYEVDHKKAIHITEDIFRMLPASPPFLSHPFKHCAVVGNGGILKNSSCGIEIDNSDFVFRCNLPPTTGSISKDVGNKTNLVTVNPSIIAQKYKKLKAKKMTFLQNIAVYGDAFLLLPAFSFRSNTAASFKVYHTLHEFGAKQRAIFFHPSLVSVDETNQNPEEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQG6</accession>
    <name>A0A151MQG6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-binding cassette sub-family B member 5</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ABCB5 P-gp</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">p-glycoprotein ABCB5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0019242</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33147"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64677"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:33148"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQG6"/>
    <dbReference type="STRING" id="8496.A0A151MQG6"/>
    <dbReference type="KEGG" id="amj:102567326"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000046">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="704"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="973"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="23">
        <location>
            <begin position="59"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="22">
        <location>
            <begin position="396"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="23">
        <location>
            <begin position="708"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="22">
        <location>
            <begin position="1035"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO26786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1277" mass="140968" checksum="A3534505A19212F2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRY7</accession>
    <name>A0A151MRY7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005226">
        <property type="protein sequence ID" value="KYO27285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRY7"/>
    <dbReference type="KEGG" id="amj:102561655"/>
    <dbReference type="eggNOG" id="ENOG502SG7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071349at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029171">
        <property type="entry name" value="DUF4638"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35679">
        <property type="entry name" value="RIKEN CDNA 4933402J07 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35679:SF1">
        <property type="entry name" value="RIKEN CDNA 4933402J07 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15472">
        <property type="entry name" value="DUF4638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO27285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="321" mass="36612" checksum="C70EA182FD340857" modified="2016-06-08" version="1">MADMSWKTMDRGIMDWLDSKRAKILRVSNDRESFQNCAFCSLAIKLKKIRRSLDTMKSMNDTLMKQEERKAKRWLVKQAELLPAPSYKNLCKMPSSKMTPEANQAIQQVSGRQSTETPCSQFGDHLANFVSFLRRPTKRTDTKHSKDVIPFSRTDLSLKTVSAKNSYGPQVTSYNMHPTASISKKGSSARRLNMENNNLSTRDAISRFPSLQKLSVTGDKLSFSKLALHDPFYGSPAAEKRMKSIFESPWQEERLKQTVTLPQIRPEEFLSCRYLRLSQSNINTLLQLCKESGVHMEIHPHMKESEININTVLSSNLSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV60</accession>
    <name>A0A151MV60_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ELM2 and SANT domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ELMSAN1</name>
        <name evidence="12" type="ORF">Y1Q_0016020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV60"/>
    <dbReference type="STRING" id="8496.A0A151MV60"/>
    <dbReference type="eggNOG" id="KOG4167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000086">
        <property type="entry name" value="transcriptional-regulating factor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF24">
        <property type="entry name" value="MITOTIC DEACETYLASE-ASSOCIATED SANT DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="332"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="439"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="594"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO28443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="678" mass="75825" checksum="819DF48931EEDEAD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXW0</accession>
    <name>A0A151MXW0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXW0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9523" checksum="EB1D7177575E4D94" modified="2016-06-08" version="1">MFWFKLPLSQVKCLPTLSAGELSPRHEAGAMHGKKVPVPNYVRQEATGGYSRILYGTHGTAMEGSWRERSAKLSDTWIPNVIQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MY64</accession>
    <name>A0A151MY64_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MY64"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8547" checksum="A47E9DFD5C00B639" modified="2016-06-08" version="1">MRSGFLHEYPIRDNLSQGHEKEAFVTSRRTASLGKMKSFSLVKSLNSHQLVQLCFLKGLHPSSLLVPDEGYLCQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYN5</accession>
    <name>A0A151MYN5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 638</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZNF638</name>
        <name evidence="10" type="ORF">Y1Q_0004963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004653">
        <property type="protein sequence ID" value="KYO29568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MYN5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12716">
        <property type="entry name" value="RRM1_2_NP220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033096">
        <property type="entry name" value="ZNF638_RRM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="463"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="1683"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="766"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="976"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1463"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1532"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="586"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="977"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1227"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1270"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1301"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1343"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1535"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1569"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1623"/>
            <end position="1636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO29568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1764" mass="193464" checksum="41090C2882ED822B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYR4</accession>
    <name>A0A151MYR4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHC class I-like antigen recognition-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0013165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004635">
        <property type="protein sequence ID" value="KYO29585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYR4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF235">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHC class I-like antigen recognition-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO29585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="237" mass="25703" checksum="C3B05CFCC289F352" modified="2016-06-08" version="1">MAMSSTKTTALEATCGLATRGEDSISYDPGTCIWVAETTQAQITQRRWNEDKAALQDARYYLEETCTARLRKYLQHGEEALQSSECWCHHPGQHGNAHSILLCPGCPALLWDTMPLSLPLPGLLVGQSPRGVCDLATCLRTRDQLMSHGTGERQAISGWTHHPVLPGPQLLPQERQATEHGAARYEAAPAQEAVEREAFKAAEKEAVESEASDAMEREALESEALASKASASSGSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZH2</accession>
    <name>A0A151MZH2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptor 142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPR142</name>
        <name evidence="13" type="ORF">Y1Q_0012952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004402">
        <property type="protein sequence ID" value="KYO29956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZH2"/>
    <dbReference type="STRING" id="8496.A0A151MZH2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052477">
        <property type="entry name" value="Orphan_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 142-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="61"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO29956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="354" mass="38316" checksum="566994A55870EA01" modified="2016-06-08" version="1">MQGDTRTGEPEGTPCRGCSMLLQDGSWPNSTTPAGEERSPCVVGIIPIVYYSVLLALGLPANVLTAAALSRLAARTKKSSYWHLLALTASDILAQVLIVFVGFILQTGILGRAMPAAAVHAVTALEFAASHASVWVAVLLAVDRYVALCHPLRHRVLCHPARSRRLIAAVFTVALATGVPFYWWLDVWRDADPPTALDRALKWLHCVAIYFLPCGIFLATNSAITCQLRRAPGPRRGRDRASALLLAVTSVFALLWAPRTAVMLCHLYVASVRRDWRVHLALDVANMVAMLNTALNGLLYCCVSRTFRHAVAEVLRSSRPLCAAGHASRQPARQGGSPPPPSLKMLGLLRGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZT8</accession>
    <name>A0A151MZT8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC30</name>
        <name evidence="3" type="ORF">Y1Q_0000185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004374">
        <property type="protein sequence ID" value="KYO30030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZT8"/>
    <dbReference type="eggNOG" id="ENOG502SNA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052825">
        <property type="entry name" value="CCD-Prefoldin_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031476">
        <property type="entry name" value="DUF4686"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15742">
        <property type="entry name" value="DUF4686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="654"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="762"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO30030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1155" mass="134737" checksum="EBD788ED3BEF076A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZZ5</accession>
    <name>A0A151MZZ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004379">
        <property type="protein sequence ID" value="KYO30005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZZ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11873" checksum="781C00ECBD61272F" modified="2016-06-08" version="1">MRIAGQADQLTTEFIDEHGQVRIAALGRSLAGADIWFFRCQGLKWQQWEIKNENDPRDENWMWLTNATLCRPVPRPPNVILGYNADVWNLTIYRLTWKLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N031</accession>
    <name>A0A151N031_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004325">
        <property type="protein sequence ID" value="KYO30124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N031"/>
    <dbReference type="STRING" id="8496.A0A151N031"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="154" mass="15931" checksum="A58B609A9895E35B" modified="2016-06-08" version="1">MAAMGPPPVNTFSTVNLEEFSSLGLSPRPPGEAETHLADALLQLQFEGNADGPGGLDLDALVDDVTYTSLEAINTAEFRQLLQGQPGGGTTEPGPPMLLSYPESITRLVNSQRGAPDGEDPSTSSFVNGALGDEMLPSMGDLDLSALLSQLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1K8</accession>
    <name>A0A151N1K8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0008310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1K8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000057">
        <property type="entry name" value="Short stature homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF2">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="121"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO30691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="322" mass="35216" checksum="758064F05016788C" modified="2016-06-08" version="1">MPESTLDSPLELISPVSQFSSSLNLLVQVQQLCQCPQGTMFSPGYVVPLPEAACFCGPTFPPRLPSAPICSLFFPAPFFSNQLFQPHSPPEPRKQALLPAGQDTGLGLARGFSEEVRPLKQRRARANYSSWQLEELESAFETTQYPDIFMREALALRLDLMEARVQVWFQNRRAKMRRQLKLQGRALDQTLAGSTSSSGDAKPQDALETEDLSDNCGFRKTGADHQPDADPEGRAPPRPPLCRAAMEIVGPGSEEAISFGAKQSAKNTRDLDLNSQVTCPSIPLTVRTESFGSVSSEAGAAAAGQCRHTHEPSIVIYLQIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N256</accession>
    <name>A0A151N256_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N256"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="89" mass="9743" checksum="4F6B1F5298F8904B" modified="2016-06-08" version="1">MAGASERRESSTSAASPAGDGGRFWCCSSTCCKRWHKKPRLEAVSAKSGVPCDFFAESLEQKNLLKIKHWLPNGVFLIGCVLQKVKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2Q3</accession>
    <name>A0A151N2Q3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0016457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2Q3"/>
    <dbReference type="eggNOG" id="ENOG502S8BD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05716">
        <property type="entry name" value="IgV_pIgR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000370">
        <property type="entry name" value="CMRF35-like molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050671">
        <property type="entry name" value="CD300_family_receptors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860:SF87">
        <property type="entry name" value="CMRF35-LIKE MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860">
        <property type="entry name" value="POLYMERIC-IMMUNOGLOBULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585680" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO31103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="218" mass="24645" checksum="558414D38353381E" modified="2016-06-08" version="1">MWMLPLWLWILFPGSVAVTGPRTVTGPEGGSVSVTCRYDKGYEENGKFWCREGSSFRCLNGEFILETNGSEAKVREGRFSIQDNHSLHVFTVSMEHLTKADAGTYHCGVLRTRLPDPRHPVEVIVSPVTKAEEEAEDYKIAVVLHCTGEKPLEIYNVQGMFADPNNKTLPETHETSTRQCLRHRFSIPTVEDVQKNVSGKQLYTILDEKDGYWQVKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2Q4</accession>
    <name>A0A151N2Q4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chondroadherin isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHAD</name>
        <name evidence="12" type="ORF">Y1Q_0016443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2Q4"/>
    <dbReference type="STRING" id="8496.A0A151N2Q4"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000059">
        <property type="entry name" value="Chondroadherin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF161">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585674" evidence="10">
        <location>
            <begin position="21"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="11">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO31084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="312" mass="35076" checksum="CC58CA26E91C4128" modified="2016-06-08" version="1">MDRSSFFLSLLVCLLPVLQACPPSCHCHGGDLQHVICDNVGLKKIPKVPEQTRLLNLQRNNFPVLPTNAFREMKGLVSLHLQHSHIKEISSGAFRGLKQLVYLYLSNNDISVIKMGAFDDLTELTYLYMDNNKISDLPKGLLSPMINLFILQLGSNKIRELRSGAFSGTKDLRWLYLSDNSLSSIQPGALDDVENLAIFHLDKNQLSTYPVAAMNKLRVVEDLKLSHNPMKVIPDNAFQSFGRYLETLSLDNTGLEKFTDHAFSGVTTLKTVHLENNKLTQLPSNFPFGKLEKLTLSNNPWHCSCQLAPLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N399</accession>
    <name>A0A151N399_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urotensin-2 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Urotensin II receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0016567</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N399"/>
    <dbReference type="STRING" id="8496.A0A151N399"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001604">
        <property type="term" value="F:urotensin II receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14999">
        <property type="entry name" value="7tmA_UII-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000466">
        <property type="entry name" value="Urotensin 2 receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000670">
        <property type="entry name" value="Urot_II_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF53">
        <property type="entry name" value="UROTENSIN-2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00647">
        <property type="entry name" value="UROTENSIN2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="8"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO31252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="327" mass="37385" checksum="BC47F9AE62936E36" modified="2016-06-08" version="1">MYVAGVAGNVYTLAVMCHSTRCAAPMYSSIVSLALADLLYLSTIPFVVCTYLAQDWYFGDLGCRLLLSLDLLTMHASIFTLTLMCAERYLAVTRPLDTLKRSQGYRKVTAGAVWSVSLLLTLPMMLMVTLSEGGKAGGRVKRMCAPTWSVDAYRTYLTVLFSTSIMAPGIIIGYLYTRLARTYLESQRNPPHKKENKRSPRQKVLIMIFTIVLVFWACFLPFWIWQLVRLYNSSLQLTLQTQKCINYLVTCLTYSNSCINPFLYTLLTKNYREYLRNRHRNFYKFTSSFRKRGSNLQCSWGRTSDEGEKLQTPKPGEHQAKGFCHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3N0</accession>
    <name>A0A151N3N0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abhydrolase domain-containing protein 12B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ABHD12B</name>
        <name evidence="2" type="ORF">Y1Q_0002566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004091">
        <property type="protein sequence ID" value="KYO31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019349635.1">
        <property type="nucleotide sequence ID" value="XM_019494090.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3N0"/>
    <dbReference type="STRING" id="8496.A0A151N3N0"/>
    <dbReference type="GeneID" id="102567571"/>
    <dbReference type="CTD" id="145447"/>
    <dbReference type="eggNOG" id="KOG1552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF69">
        <property type="entry name" value="PROTEIN ABHD12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="288" mass="32180" checksum="6C95FD4DEE26E09C" modified="2016-06-08" version="1">MFKFPFFVDLSRPELLLNHTVNFYLTTEPEVTIGVWHSVPASRGIEAQGKDHSWYEEALGDDNPVILYLHGNGATRAANHRVNLIKVMSAIGFHVLAVDYRGYGDSSGSPSEGGFTKDILYLYDWVKARSGKSRVFLWGHSLGTGIATNVARKLLEDRGTQVDGLILESPYTNIRDAAANIPVTKIYRQFPGFDYLILDTLALADLFFQSDENVKVLTSPILILHAEDDPVIPSHLGRKLFETAISAYQDKNKVRFVAFPDKLGLAHDYISFHPDLPAVVKDFLKNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3Z1</accession>
    <name>A0A151N3Z1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein LZIC isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LZIC</name>
        <name evidence="5" type="ORF">Y1Q_0006075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTNNBIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3Z1"/>
    <dbReference type="STRING" id="8496.A0A151N3Z1"/>
    <dbReference type="eggNOG" id="ENOG502QPUB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.490">
        <property type="entry name" value="Beta-catenin-interacting ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009428">
        <property type="entry name" value="ICAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036911">
        <property type="entry name" value="ICAT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47142">
        <property type="entry name" value="BETA-CATENIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47142:SF1">
        <property type="entry name" value="BETA-CATENIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06384">
        <property type="entry name" value="ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81730">
        <property type="entry name" value="beta-catenin-interacting protein ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-catenin-interacting ICAT" evidence="4">
        <location>
            <begin position="336"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="229"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO31498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="413" mass="46366" checksum="201D12098DCFCE23" modified="2016-06-08" version="1">MIFSLVLTAYHLSGWLSKHHRFRVLLFRPNFSQCISQTLLSSLVGGIIFVFFTFGLPSVLTFTKPTSWELKVIFCIFSSGSLPQGVCTIVLATQCVKIIPELYCVSMMLSMSSMTSAATSLPGKFPQGCSRFPTPFIMKKLTEPCSSHSGKNLTLASAGRVAMGTGEGRSWTCLCNAQSSSFKRSNLEYIRFMVLVNQPGYPEARKREEPRFLRELFPCKDFKMASRGTTETSKLKQNLEEQLDRLMQQLQDLEECREELDADEYEETKKETLEQLSEFNESLKKIMSGNMTLVDELSGMQLAIQAAISQAFKTPEVIRMFAKKQPRQLRTRLAEMDRDLMVGKLGRDLYTQQKVEILTALRKLGEKLTADDETFLSSNAGAALSQFERVSSDLGSGDKVFALASVEVEKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4R4</accession>
    <name>A0A151N4R4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Malectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MLEC</name>
        <name evidence="14" type="ORF">Y1Q_0022783</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449132.2">
        <property type="nucleotide sequence ID" value="XM_014593646.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4R4"/>
    <dbReference type="STRING" id="8496.A0A151N4R4"/>
    <dbReference type="GeneID" id="106737654"/>
    <dbReference type="KEGG" id="amj:106737654"/>
    <dbReference type="CTD" id="9761"/>
    <dbReference type="eggNOG" id="KOG3593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151N4R4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000006">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039155">
        <property type="entry name" value="MLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460:SF0">
        <property type="entry name" value="MALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585742" evidence="12">
        <location>
            <begin position="34"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="13">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO31687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="280" mass="30669" checksum="B8C23FE2544B8C97" modified="2016-06-08" version="1">MVGTGARCGPGAALLLGALLGAAVAAAAGGGLADNVVWAVNAGGEGHVDVHGIHFRKDPLEGRVGRASDYGMKLPILRSNAEDQILYQTERYNEETFGYEIPIKEEGDYVLVLKFAEVYFAQSQQKVFDVRLNGHVVVKDLDIFDRVGHSTAHDEIIPMSIKKGKLSVQGEVSTFTGKLQIEFVKGYYDNPKICALYLLQGTVDDVPKLQPHPGLEKKEDEDDEEEYEEGPNVKKQANKNRVQSGPRTPNPYASDNSSLMFPILVAFGVFIPTLFCLCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5N0</accession>
    <name>A0A151N5N0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH2B adapter protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adapter protein with pleckstrin homology and Src homology 2 domains</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">SH2 and PH domain-containing adapter protein APS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SH2B2</name>
        <name evidence="16" type="ORF">Y1Q_0007039</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homodimer. Interacts with KIT/c-KIT, SHC1, EPOR, PDGFR, VAV1 and VAV3. Interacts (via N-terminal region) with SHC1. Interacts (via the phosphorylated C-terminus) with GRB2. Interacts (via its SH2 domain) with EPOR, INSR and KIT. Interacts with GRB2 after B-cell antigen receptor stimulation. Interacts (via PH domain) with VAV3. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated); after stimulation of the receptor by its extracellular ligand and subsequent autophosphorylation of the receptor. Binds INSR, GRB2, ASB6 and CAP. Insulin stimulation leads to dissociation of CAP. Binds CBS only when SH2B2/APS has become phosphorylated. INSR binding does not depend on the phosphorylation of SH2B2/APS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SH2B adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5N0"/>
    <dbReference type="STRING" id="8496.A0A151N5N0"/>
    <dbReference type="eggNOG" id="ENOG502QT43">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050851">
        <property type="term" value="P:antigen receptor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01231">
        <property type="entry name" value="PH_SH2B_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10411">
        <property type="entry name" value="SH2_SH2B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000008">
        <property type="entry name" value="SH2B adapter protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000187">
        <property type="entry name" value="SH2B adapter protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015012">
        <property type="entry name" value="Phe_ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036290">
        <property type="entry name" value="Phe_ZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030523">
        <property type="entry name" value="SH2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035058">
        <property type="entry name" value="SH2B2_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10872">
        <property type="entry name" value="SH2B ADAPTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10872:SF4">
        <property type="entry name" value="SH2B ADAPTER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08916">
        <property type="entry name" value="Phe_ZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109805">
        <property type="entry name" value="Phenylalanine zipper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="255"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="482"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="623"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO32007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="693" mass="77419" checksum="C2FDE9D11C011409" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NA13</accession>
    <name>A0A151NA13_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain family 4 member D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CLEC4D</name>
        <name evidence="4" type="ORF">Y1Q_0000782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003720">
        <property type="protein sequence ID" value="KYO33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NA13"/>
    <dbReference type="STRING" id="8496.A0A151NA13"/>
    <dbReference type="GeneID" id="102564984"/>
    <dbReference type="KEGG" id="amj:102564984"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6337382at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="90"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="224" mass="25217" checksum="6455C6BCBF41922A" modified="2016-06-08" version="1">MSTEGRPSPGAPAEERGGCPRLSPWALLILAFILKACVTCGCLVALLKGHQSCGDHRVLPQDLKEGICVLERHENKEQVWMCCPIGWKLFHTSCYYLSNNIMTWAESETNCTGMGSHLVVISTKAEQEFLFNWIKGAVAGSQEKNHYIGLSAQEMEGQWHWVDQTLYNQTTMFWRPGEPNNPEVEKCAVMYVGGQADDPWSKNWNNIPCETDCYRICEVAATRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBT5</accession>
    <name>A0A151NBT5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Steroidogenic acute regulatory protein, mitochondrial</fullName>
            <shortName evidence="12">StAR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">START domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STAR</name>
        <name evidence="14" type="ORF">Y1Q_0018155</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Steroid metabolism; cholesterol metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May interact with TSPO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003560">
        <property type="protein sequence ID" value="KYO34276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266195.2">
        <property type="nucleotide sequence ID" value="XM_006266133.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBT5"/>
    <dbReference type="STRING" id="8496.A0A151NBT5"/>
    <dbReference type="GeneID" id="102572945"/>
    <dbReference type="KEGG" id="amj:102572945"/>
    <dbReference type="CTD" id="6770"/>
    <dbReference type="eggNOG" id="KOG3845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="UniPathway" id="UPA00296"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050810">
        <property type="term" value="P:regulation of steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08905">
        <property type="entry name" value="START_STARD1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000015">
        <property type="entry name" value="Steroidogenic acute regulatory protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029866">
        <property type="entry name" value="StAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46489">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46489:SF1">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="13">
        <location>
            <begin position="92"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO34276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="287" mass="31741" checksum="3A99DA9580C60EF3" modified="2016-06-08" version="1">MLPATFKLCAGISYRHLRNMTGLRRKAAVAISQELNKLAFAGTGPGKWINQVRRRSSLLSSRLEERPFNEVEMSYLKQGEEALQKSLSILGDQDGWKTETAVGNGDRVLSKVLPDVGKVFRLEVVVDQPLDSLYDELVERMEQMGDWNPNVQEVKILQKIGKDTLITHETAAATPGNIVGPRDFVSVRCTKRRGSTCVLAGMATKHGAMPEQKGFVRAENGPTCMILRPVAENPSQTKLTWLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLASPAPPAVAVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCH6</accession>
    <name>A0A151NCH6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZFR</name>
        <name evidence="13" type="ORF">Y1Q_0011947</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003404">
        <property type="protein sequence ID" value="KYO34516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCH6"/>
    <dbReference type="STRING" id="8496.A0A151NCH6"/>
    <dbReference type="GeneID" id="102564214"/>
    <dbReference type="KEGG" id="amj:102564214"/>
    <dbReference type="CTD" id="23217"/>
    <dbReference type="eggNOG" id="KOG3792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8898434at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000001">
        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000153">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000210">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000439">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000010">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF2">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="619"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="229"/>
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        </location>
    </feature>
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            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="946"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
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            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
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            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
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            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="976"/>
            <end position="990"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO34516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="990" mass="110300" checksum="97EA1183AA3684B4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
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                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
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                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
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                <person name="Green R.E."/>
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            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NE23"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="16840" checksum="92BFDED7E586DA68" modified="2016-06-08" version="1">MRATVTLMGLQRHHFWAHQASQDWLQHIVQHISYDEQWLEAFCMTWITFQDLLELLWLYLEWQDTGMWPHPTTDTCLALTVLKLATPSSLRYVGHLFGMGNTTTREAVLEVCSALQDGQGDTIVTRFAHYFGVCSFIRDTFLGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A151NFJ7_ALLMI</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008098</name>
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        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
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                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="136" mass="15196" checksum="F7EB013C6CB76B4D" modified="2016-06-08" version="1">MAMTNTHENGWIRLLLTSVPIMGVAFSPKAGTLKTCEENAVQARWQWDILSVKLTVILHQSPAGGQELMTGLSVQFSTAVGQRWRRLIPIPYRLSQEDQPATGLEYPGNDHVPGAGCQMCVRLSDYRNRHFRGFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFR2</accession>
    <name>A0A151NFR2_ALLMI</name>
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    <organism evidence="2 3">
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
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                <person name="Ray D.A."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003127">
        <property type="protein sequence ID" value="KYO35666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFR2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="12107" checksum="2DEACEBF09C3A414" modified="2016-06-08" version="1">MSPASCELHASPGSPSSGIGSPHETEWPPPPPVLSKLPTAKTSILSWVYPSAWQRTRPTDRVLWRDHSSGLSKENKLFLEALERSGRTTQMLEEKSFMLLNTAYGLMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIF4</accession>
    <name>A0A151NIF4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.244</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">B4GALNT3</name>
        <name evidence="13" type="ORF">Y1Q_0024294</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61631"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:138027"/>
            <dbReference type="EC" id="2.4.1.244"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus</location>
            <location evidence="1 10">Golgi stack membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.244" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIF4"/>
    <dbReference type="STRING" id="8496.A0A151NIF4"/>
    <dbReference type="eggNOG" id="KOG3588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NIF4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000063">
        <property type="entry name" value="Beta-1,4-N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF15">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="100"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO36592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1056" mass="121256" checksum="1FD6C946D55B3582" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIM5</accession>
    <name>A0A151NIM5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="10">5.4.2.11</ecNumber>
            <ecNumber evidence="10">5.4.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BPGM</name>
        <name evidence="11" type="ORF">Y1Q_0024329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17765"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="EC" id="5.4.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="10"/>
    <dbReference type="EC" id="5.4.2.4" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014464792.1">
        <property type="nucleotide sequence ID" value="XM_014609306.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIM5"/>
    <dbReference type="STRING" id="8496.A0A151NIM5"/>
    <dbReference type="GeneID" id="102568684"/>
    <dbReference type="KEGG" id="amj:102568684"/>
    <dbReference type="CTD" id="669"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NIM5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004082">
        <property type="term" value="F:bisphosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000012">
        <property type="entry name" value="Phosphoglycerate mutase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO36648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="260" mass="29710" checksum="3A148474B1AC3290" modified="2016-06-08" version="1">MTKYKLVLLRHGEGAWNKENRFCSWVDQKLSSDGIKEAQNCGKHLKSLGFEFDLVFTSILTRSIQTACLVLEEMGQEWVPVQKSWRLNERHYGALIGLNRAEMALNHGEEQVKIWRRSYDVAPPPITESHPYYNEIYNDRRYKSCDVPEDKLPRAESLKEVLLRLLPYWNEKIVPELKSGKTILISAHGNSARALLKHLEGISDEHIANVTLPTGVPVLLELDENLHPLSPHQFLGDQEAIQAAIKKVEDQGKVIPTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJA6</accession>
    <name>A0A151NJA6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LRRC40</name>
        <name evidence="6" type="ORF">Y1Q_0020897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJA6"/>
    <dbReference type="STRING" id="8496.A0A151NJA6"/>
    <dbReference type="GeneID" id="102577318"/>
    <dbReference type="KEGG" id="amj:102577318"/>
    <dbReference type="CTD" id="55631"/>
    <dbReference type="eggNOG" id="KOG0472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000116">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000193">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000206">
        <property type="entry name" value="leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000265">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="5">
        <location>
            <begin position="86"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="5">
        <location>
            <begin position="246"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO36871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="594" mass="66543" checksum="C2B194797798B8E4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKY7</accession>
    <name>A0A151NKY7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKY7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="10927" checksum="B6691D52AAE5AA91" modified="2016-06-08" version="1">MDCHCCSPKRPHGPQHLTMETSTQFEDDSLGSVAFIYISMTVSLISTSSGKEAINCTCNQRCRNLSKSMILNHDFGVLRGHKLFEECSRKCEEIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLT8</accession>
    <name>A0A151NLT8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002600">
        <property type="protein sequence ID" value="KYO37767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLT8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="10963" checksum="4C908A14702F0DCB" modified="2016-06-08" version="1">MAHEDAQDQCKEAWNQHSEVRDQADWEFWAQLLALMYEWVKALQEQTTVLERAVQATGNDCQVLDTILALAIIFMPTHCPTPDPSPGCSLEATCCLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMC8</accession>
    <name>A0A151NMC8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">H2AFZ</name>
        <name evidence="14" type="ORF">Y1Q_0019462</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002540">
        <property type="protein sequence ID" value="KYO37976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMC8"/>
    <dbReference type="SMR" id="A0A151NMC8"/>
    <dbReference type="STRING" id="8496.A0A151NMC8"/>
    <dbReference type="GeneID" id="102562945"/>
    <dbReference type="KEGG" id="amj:102562945"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NMC8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO37976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="128" mass="13583" checksum="E031E537B2930371" modified="2016-06-08" version="1">MAGGKAGKDSGKTKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPU9</accession>
    <name>A0A151NPU9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Carboxypeptidase A5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CPA5-2</name>
        <name evidence="16" type="ORF">Y1Q_0023508</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPU9"/>
    <dbReference type="STRING" id="8496.A0A151NPU9"/>
    <dbReference type="GeneID" id="102563344"/>
    <dbReference type="KEGG" id="amj:102563344"/>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NPU9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03870">
        <property type="entry name" value="M14_CPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000132">
        <property type="entry name" value="Carboxypeptidase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000001">
        <property type="entry name" value="Carboxypeptidase A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034248">
        <property type="entry name" value="CPA_M14_CPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF152">
        <property type="entry name" value="CARBOXYPEPTIDASE A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586264" evidence="14">
        <location>
            <begin position="17"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="121"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO38851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="422" mass="47427" checksum="5691B515618B1819" modified="2016-06-08" version="1">MTGLLVFGALLAVACSQKLFVGDQVLRISANNEEHVALLRGLEELEDLQLDYWAAPAKPGLPVDIRVPFPSLQPVKIFLESNGIPYTIMIEDVQTLLDEEKEAMERARKLERSSSGFDFSTYHTIEEIYSWMDDLVAQHPDLVSKIQIGESYEKRPLYVLKFSTGRTVKTHRPAIWIDTGIHSREWITQATGVWTANKIATEYGKDASLTAILTSMDIFLEIVTNPDGFAYTHSQNRMWRKTRSINAGSSCKGVDPNRNWDAGFGGPGAANNPCSETYHGPYPFSESETKSVADFILSHGKMKAAISIHSYSQMLMFPYGYKEEPAPNHQELDDLAKEAVDALAAVHGTQYRYGSTIHTIYQADGITIDWTYDNGVKYSYTFELRDTGRYGFLLPAAQIIPTAEETWPALMKIMVHVHEHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQI8</accession>
    <name>A0A151NQI8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ZW10 interactor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ZWINT</name>
        <name evidence="1" type="ORF">Y1Q_0013069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002424">
        <property type="protein sequence ID" value="KYO38909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQI8"/>
    <dbReference type="STRING" id="8496.A0A151NQI8"/>
    <dbReference type="eggNOG" id="ENOG502S6PG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029092">
        <property type="entry name" value="Zwint-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31504:SF1">
        <property type="entry name" value="ZW10 INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31504">
        <property type="entry name" value="ZW10 INTERACTOR ZWINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15556">
        <property type="entry name" value="Zwint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="352" mass="38711" checksum="2B6E1771A0B28825" modified="2016-06-08" version="1">MWKILAEVEAALEPPERDREEPELPARVRAEYAADTRQKQKLLCSQLQVVAFLLDAFAKAPGPRPNQEHSDALVRQEVIAAKQCWKELKAGYQAGVAALTEAAPGALAQFNRAQCQAQCLQDALTRHQHQRQGTLKKQWVAQEQLLQEQVLGLRAKVTSGCTKRSHLQGELQSLQDEAQAWRDTAQQALDWCHLLETLQGAQLLLPMGGRTSPEAAELELSWAPPPGDLEAAGPPLRVALCQASGGKVEVMALPPGLGPALLELEWSRRCQAQLLAEITELQHRFAIDWDPQRRHLRLLCPTAVWTLEVEPGYPGDGGVRLSTGSPLPCLGQPPQEASSLSNWLEYLSALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQS3</accession>
    <name>A0A151NQS3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sarcoplasmic reticulum histidine-rich calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HRC</name>
        <name evidence="2" type="ORF">Y1Q_0004893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002375">
        <property type="protein sequence ID" value="KYO39124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQS3"/>
    <dbReference type="STRING" id="8496.A0A151NQS3"/>
    <dbReference type="eggNOG" id="ENOG502S3MW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015666">
        <property type="entry name" value="HRC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15054">
        <property type="entry name" value="HISTIDINE-RICH CALCIUM-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15054:SF3">
        <property type="entry name" value="SARCOPLASMIC RETICULUM HISTIDINE-RICH CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10717" checksum="BA6C579B0E003579" modified="2016-06-08" version="1">MLSSWKGTEEEEEGEEEYQPGSVCQYCEFCKHCGECDKCPCLEGDASPYCEACQHCHFCYMCPVCETACQPGSIVDEMSGALFQMIATIFERQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRA9</accession>
    <name>A0A151NRA9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002234">
        <property type="protein sequence ID" value="KYO39376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRA9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO39376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7978" checksum="76553B8297D373AA" modified="2016-06-08" version="1">MAARVTQVKGRRLLRRCWRYQDGAWGTVPRALSTELLEVLDAGDRRLVLRRRRGAPWVPPKRDRAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTD3</accession>
    <name>A0A151NTD3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002106">
        <property type="protein sequence ID" value="KYO40003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTD3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="239" mass="25774" checksum="F16ECC7BC8791A31" modified="2016-06-08" version="1">MPVAKTSPRCLVKDSKQCIGLMPQAVPCSQGASCTGRGARDTERHLKSFLGQAPGAGWGRDFLLLPLLVPPAQVLYRSKVMKKKKNMGASRRPPPARPRQLRDLDERGDSGEAMERSGLGWCSRCWRGRLMAVGRSHGLSSRWPGLEQEAGLSAPQQAALGRGARSSPWRVGFGAQGKEDAVTVPVAQGQEQTQQPPATVGRDGDVALTPRPRSLDSSPRVMDAGLLLQFRKSLLSFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTD7</accession>
    <name>A0A151NTD7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002075">
        <property type="protein sequence ID" value="KYO40152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTD7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="191" mass="17680" checksum="71B1D49F373587E1" modified="2016-06-08" version="1">METKGSPGGTGRRLESGGSTGKPIPREVQPLHWAAQDGRGRSCGSTGSIADIKAGREAGSRACGGTNSKTSREASSGVCGGTNSEAGREAGSGASGDTSSGADSGAGGSTSRGDSRGASGGIISSTGSEASSSTGRGAGGGISSGTSREAGSSTGSGAGRGIGSSTGREAGRGASSSTSGEANGGRGSEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUV7</accession>
    <name>A0A151NUV7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-tectorin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TECTB</name>
        <name evidence="16" type="ORF">Y1Q_0009585</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUV7"/>
    <dbReference type="STRING" id="8496.A0A151NUV7"/>
    <dbReference type="GeneID" id="102571762"/>
    <dbReference type="KEGG" id="amj:102571762"/>
    <dbReference type="CTD" id="6975"/>
    <dbReference type="eggNOG" id="ENOG502RGQ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9856536at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NUV7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4100:FF:000006">
        <property type="entry name" value="beta-tectorin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017977">
        <property type="entry name" value="ZP_dom_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF13">
        <property type="entry name" value="BETA-TECTORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00682">
        <property type="entry name" value="ZP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586401" description="Beta-tectorin" evidence="14">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="15">
        <location>
            <begin position="34"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO40568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="332" mass="37083" checksum="7CB779341B2130E9" modified="2016-06-08" version="1">MVIVAVYFLVILAGHRAYAPPPCNPNKADAVLVYCYPNTIITRIPECPYGWEVSQLALGGVCYNGIHDSGYYQFTIPDLSPKNKSYCGTQSEFKSPLYHFYNSIVSNDTTVIVKSQPVNYSFTCTYRANYLVNQAAFDQRVATIHVKNGSSGSFESQLSLNFYSNAKFSTKKEAPFVVETSEIGSDVFAGVEAKGLSGRFKVVLNNCWATPTAEYFYQIQWPLITKGCPTDDSILVHENGKAARATFQFNAFRFRNIPKLSKVWLHCETHICDSEKFSCPVTCEKRKQRMEQTGGVLVVELAVRSKGLSSLSHLSDILFHLIFMIGMCAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX98</accession>
    <name>A0A151NX98_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glutamate carrier 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glutamate/H(+) symporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SLC25A22</name>
        <name evidence="18" type="ORF">Y1Q_0006306</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton. Plays a role in the control of glucose-stimulated insulin secretion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamate(in) + H(+)(in) = L-glutamate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014459697.1">
        <property type="nucleotide sequence ID" value="XM_014604211.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340698.1">
        <property type="nucleotide sequence ID" value="XM_019485153.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340700.1">
        <property type="nucleotide sequence ID" value="XM_019485155.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340701.1">
        <property type="nucleotide sequence ID" value="XM_019485156.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340702.1">
        <property type="nucleotide sequence ID" value="XM_019485157.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX98"/>
    <dbReference type="GeneID" id="102568464"/>
    <dbReference type="KEGG" id="amj:102568464"/>
    <dbReference type="CTD" id="79751"/>
    <dbReference type="eggNOG" id="KOG0750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NX98"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000017">
        <property type="entry name" value="Solute carrier family 25 member 22a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLUTAMATE CARRIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="101"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="220"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO41521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="320" mass="34777" checksum="72A73B460E7B072D" modified="2016-06-08" version="1">MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRMYTSMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHHLSKDGKKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQKKLMAAQAQISSSTGAAESVVERRTTATQITRELLRSKGIAGLYKGLGATLLRDVPFSIVYFPLFANLNKLGQKSPDIKAPFYVSFLSGCLAGSTAAVAVNPCDVIKTRLQSLQRGVNEDTYSGILDCARKIWQKEGPMAFLKGAYCRALVIAPLFGIAQVVYFIGIAEFLLDLFPKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXU0</accession>
    <name>A0A151NXU0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">26S proteasome regulatory subunit S11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">26S proteasome regulatory subunit p40.5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PSMD13</name>
        <name evidence="10" type="ORF">Y1Q_0006373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274944.1">
        <property type="nucleotide sequence ID" value="XM_006274882.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXU0"/>
    <dbReference type="STRING" id="8496.A0A151NXU0"/>
    <dbReference type="GeneID" id="102562036"/>
    <dbReference type="KEGG" id="amj:102562036"/>
    <dbReference type="CTD" id="5719"/>
    <dbReference type="eggNOG" id="KOG2908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NXU0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="171"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO41618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="376" mass="42850" checksum="7FF499170958ADD5" modified="2016-06-08" version="1">MKDVPGFLQQSQSSGPGQAAVWHRLEELYNKKLWHQLTLQVLDFVQDPCFAQGDGLIKLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNAALTFLEKTREKVKSSDEAVILCKTAIGALKLNIGDLQVTKETIEEVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCIDVKDLPVSEQQERAFTLGLAGLLGEGVYNFGELLMHPVLESLRNTDRQWLIDTLYAFNSGNVEKFQALKTAWGQQPDLAANETLLLQKIQLLCLMEMTFTRPANHRQLTFEEIAKSAKVTVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVRSMEMLVEHQAHDILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYR8</accession>
    <name>A0A151NYR8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0006347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYR8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9508" checksum="E8FC291E7EA69BBC" modified="2016-06-08" version="1">MWNPPSSKAADPELRDSMLQRKRILPPLLYPLKMAADPGAFRRGKYHSVVLDSDSSLLQLVLTLLLDFTLWTAPQIGIQHLIPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P090</accession>
    <name>A0A151P090_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pterin-4-alpha-carbinolamine dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Dimerization cofactor of hepatocyte nuclear factor 1-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Phenylalanine hydroxylase-stimulating protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Pterin carbinolamine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PCBD1</name>
        <name evidence="20" type="ORF">Y1Q_0022273</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Also acts as a coactivator for HNF1B-dependent transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275789.1">
        <property type="nucleotide sequence ID" value="XM_006275727.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P090"/>
    <dbReference type="STRING" id="8496.A0A151P090"/>
    <dbReference type="GeneID" id="102574554"/>
    <dbReference type="KEGG" id="amj:102574554"/>
    <dbReference type="CTD" id="5092"/>
    <dbReference type="eggNOG" id="KOG4073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P090"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00914">
        <property type="entry name" value="PCD_DCoH_subfamily_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.20:FF:000001">
        <property type="entry name" value="Pterin-4-alpha-carbinolamine dehydratase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002018">
        <property type="entry name" value="PRK00823.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002020">
        <property type="entry name" value="PRK00823.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF13">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO42433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="11955" checksum="D21628924B0383EF" modified="2016-06-08" version="1">MAGKAHRLSAEEREQLLPNLRAVGWNEVDARDAIFKEFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLATFIEQVAASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3P3</accession>
    <name>A0A151P3P3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Axin interactor, dorsalization-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AIDA</name>
        <name evidence="7" type="ORF">Y1Q_0013580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AIDA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014453519.1">
        <property type="nucleotide sequence ID" value="XM_014598033.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3P3"/>
    <dbReference type="GeneID" id="102574020"/>
    <dbReference type="CTD" id="64853"/>
    <dbReference type="eggNOG" id="ENOG502QSD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428576at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048264">
        <property type="term" value="P:determination of ventral identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.360:FF:000001">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000059">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.360">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025939">
        <property type="entry name" value="Aida_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023421">
        <property type="entry name" value="AIDA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036818">
        <property type="entry name" value="AIDA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654:SF1">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14186">
        <property type="entry name" value="Aida_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08910">
        <property type="entry name" value="Aida_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109779">
        <property type="entry name" value="Domain from hypothetical 2610208m17rik protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51911">
        <property type="entry name" value="C2_AIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 Aida-type" evidence="6">
        <location>
            <begin position="157"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO43549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="306" mass="34954" checksum="1A7F0F530EFC435E" modified="2016-06-08" version="1">MSEAARSLLQRWGASFRRGTDFDSWGQLVEAIDEYQILARHLQKEAQSQHNNSEFTEDQKKTIAKIATCLELRSAALQSTQSQEEFKLEDLKKLEPILKNILTYNKQFPFDVQPVPLRKILAPGEEENLEFEEDDEEGGAGAGSPDSFPARVPGTLLPRLPSEPGMTLLTIKIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYVHFNVDIEIQKHVEKLTKGAAIFFEFKHYKPKKRFTSTKCFAFMEMDEIKHGAIVIELYKKPTDFKRKKLQLLTKKPLYLHLHQTLHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3S9</accession>
    <name>A0A151P3S9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0020717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001138">
        <property type="protein sequence ID" value="KYO43727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3S9"/>
    <dbReference type="STRING" id="8496.A0A151P3S9"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF280">
        <property type="entry name" value="CALPAIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="42"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO43727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="613" mass="69134" checksum="B3D2B8D481616543" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4L0</accession>
    <name>A0A151P4L0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000981">
        <property type="protein sequence ID" value="KYO44007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4L0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21818" checksum="D9D840CBD026D5B8" modified="2016-06-08" version="1">MEGAEQGAREPHVPVVSQSGSLLVLAGLLALWAGLQPASGQFSPGVCRLPPESGNCLAYVHLQPPVLLRRCHRQLQGVHLWGLWGQWEPVPHLGNLSPGLLVQGNANNFKTRLECEKRCKVGGKGLSLPGPDAARGMEAPGRWPDVQGRVKLACVWKVCSRHLQAPPRTRHVRTAPHTLLLQLGVQEMPTVHLWRLPGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4U8</accession>
    <name>A0A151P4U8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000929">
        <property type="protein sequence ID" value="KYO44082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4U8"/>
    <dbReference type="STRING" id="8496.A0A151P4U8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053082">
        <property type="entry name" value="Nuclear_GTPase_SLIP-GC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47308">
        <property type="entry name" value="NUCLEAR GTPASE SLIP-GC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47308:SF1">
        <property type="entry name" value="NUCLEAR GTPASE SLIP-GC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9998" checksum="4425E47F3284C027" modified="2016-06-08" version="1">MQDIIEESVDKEVNSGMFERAAKTMKDEFQKLKEGITRTLQMDFSNMLKLTFFHKEELVKRLPDLQNEYKEIMYIHSAIQVPGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5P7</accession>
    <name>A0A151P5P7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-2-macroglobulin-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0012141</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P5P7"/>
    <dbReference type="eggNOG" id="KOG1366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF185">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586698" description="Alpha-2-macroglobulin-like protein 1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="10">
        <location>
            <begin position="403"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="11">
        <location>
            <begin position="663"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="12">
        <location>
            <begin position="1254"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO44382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1720" mass="190535" checksum="4DF01BA1BDA43118" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6F9</accession>
    <name>A0A151P6F9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000725">
        <property type="protein sequence ID" value="KYO44560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6F9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586713" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="86" mass="9476" checksum="5594B5B46257239B" modified="2016-06-08" version="1">MQQPLLKDAWLTIALLKLATPASLYYMDHFFGIGKATTKEVVLEVCSALQNMLGHTVRCMHDPLEVMVRLCALGFPQFIGALNGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9J4</accession>
    <name>A0A151P9J4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain and tetratricopeptide repeat-containing protein 1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SH3TC1</name>
        <name evidence="5" type="ORF">Y1Q_0021374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9J4"/>
    <dbReference type="STRING" id="8496.A0A151P9J4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11885">
        <property type="entry name" value="SH3_SH3TC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042772">
        <property type="entry name" value="SH3TC1/SH3TC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22647:SF3">
        <property type="entry name" value="SH3 DOMAIN AND TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22647">
        <property type="entry name" value="SH3 DOMAIN AND TETRATRICOPEPTIDE REPEATS CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="319"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO45702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="966" mass="110684" checksum="CC39596027732CFF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAK6</accession>
    <name>A0A151PAK6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibrinogen-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FGL1</name>
        <name evidence="13" type="ORF">Y1Q_0021643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Interacts (via the Fibrinogen C-terminal domain) with LAG3 (via Ig-like domains 1 and 2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAK6"/>
    <dbReference type="STRING" id="8496.A0A151PAK6"/>
    <dbReference type="eggNOG" id="KOG2579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072377">
        <property type="term" value="P:blood coagulation, common pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF8">
        <property type="entry name" value="FIBRINOGEN LIKE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586850" description="Fibrinogen-like protein 1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
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        <location>
            <begin position="75"/>
            <end position="303"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049639"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049681"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO46063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="303" mass="35431" checksum="59B6245813C5FC53" modified="2016-06-08" version="1">MKILVLFTFILVNGLIMGIDTSTLQSCLQEQLRLQAQVRLLEHRVKQQQVKIVQLLQEREIQYSDRGDENSVIDLGEKRQYADCAEIYNDGYKQSGFYKMKPLQSPSEFLAYCDMSEGGGWTVFQRRSDGSQNFDRVWADYEQGFGNFVLRNGEYWLGNKNLHYLTSQGNYTLRINLIDFEEEQRFAQYTNFRVADGESSYWMTCGEYSGTAGDSFTGGFHPEVKWWADHRGMKFSTRDRDNDNYEGNCAEEDKSGWWFNRCHSANLNGVYYKGPYTAKTDNGIVWYTWRGWWYSLKSVVMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAP4</accession>
    <name>A0A151PAP4_ALLMI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021735</name>
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    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
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                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAP4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="125" mass="13550" checksum="EB2A39DD69666C3D" modified="2016-06-08" version="1">MEAERAGLVCTPDSGASGSILCASNQFPACFRTQCGGLRGFSQALIESGSGSELVRMNAFIESPLGQTYTASKQRRKKYTARRVTRPRLLTHSYDKPVAGSTRDADCAVARYYCAVASHDVKHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBH9</accession>
    <name>A0A151PBH9_ALLMI</name>
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        <recommendedName>
            <fullName evidence="7">SLED domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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    <organism evidence="8 9">
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        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="8496.A0A151PBH9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20111">
        <property type="entry name" value="MBT_SFMBT1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20117">
        <property type="entry name" value="MBT_SFMBT1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.190">
        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021987">
        <property type="entry name" value="SLED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038348">
        <property type="entry name" value="SLED_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF77">
        <property type="entry name" value="SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12140">
        <property type="entry name" value="SLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="128"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
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            <begin position="267"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="383"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="SLED" evidence="7">
        <location>
            <begin position="529"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <end position="722"/>
        </location>
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        <location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="932"/>
            <end position="962"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO46392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113335" checksum="611AE22D590DAE26" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBR8</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020799</name>
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    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000532">
        <property type="protein sequence ID" value="KYO46374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBR8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586880" evidence="1">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="17883" checksum="2A2B079F2608F1A2" modified="2016-06-08" version="1">MELRAAVLALALLSLAGSQAAPAGKGDGSRVQQLETAVNNLIEEVMQVTCHTGQWINMLELAQELESQAGDLSDQLELELSPELQQALNKAIHSTMRLVEMALGVMNPYLDAAMKQTEQALDQALEQVLEQTEALGLDLPGALQAGAKWVLELKEQLVGPLPSPSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCN8</accession>
    <name>A0A151PCN8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCN8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586912" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9775" checksum="CB94F75FB6C85317" modified="2016-06-08" version="1">MSPPLSADIYLALALLKLATHAILWLPAKTTERTESLYCLKTSSLPPQDTREDVSGGDQVVQKQKFHNQYSTVCYRTQELYIVIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDF5</accession>
    <name>A0A151PDF5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0014005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000483">
        <property type="protein sequence ID" value="KYO47092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDF5"/>
    <dbReference type="STRING" id="8496.A0A151PDF5"/>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO47092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="292" mass="32140" checksum="42B47843DF773300" modified="2016-06-08" version="1">MPNDVVCTCLPIFTGKFCERILTPCDLSPCLNNATCVDQQQSYHCCCMPEFTGRNCEEVIDYCRLLSINCLNEGLCLNIIGGFSCLCAPGWTGEFCQFVENACLIYPNNCYNGATCIDVSHLTEEPQFQCLCLHSFTGEFCEMEIDACGSNPCKNGGTCVDLISHYKCTCPMGHEGENCELDIDACLYYNTSCSSGTLCVDRPHGLNYTCLLPCIENTESCANGGSCFFDEDSQSPHCVCALGWTGQTCLENTNDCEDNRCLYGATCEDGINEYRCHSIYATPSSVYLKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PES1</accession>
    <name>A0A151PES1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PES1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9587" checksum="F0594D876132420E" modified="2016-06-08" version="1">MAHQETWHMEYLTSLEEAWDQAEHELWAELLALEQKPLQVMWTQNNILGWAMEAMDDDCQTLDTVLGLAVSCMPTTALPPALVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PET6</accession>
    <name>A0A151PET6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SELO</name>
        <name evidence="11" type="ORF">Y1Q_0019628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PET6"/>
    <dbReference type="STRING" id="8496.A0A151PET6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153:SF15">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153">
        <property type="entry name" value="SELENOPROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="10">
        <location>
            <begin position="481"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO47499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="582" mass="67029" checksum="D7D6ADC3AA82BD0F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PF21</accession>
    <name>A0A151PF21_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein kinase TBK1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TBK1</name>
        <name evidence="16" type="ORF">Y1Q_0019791</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PF21"/>
    <dbReference type="STRING" id="8496.A0A151PF21"/>
    <dbReference type="eggNOG" id="KOG4250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032728">
        <property type="term" value="P:positive regulation of interferon-beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21954">
        <property type="entry name" value="TBK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17127">
        <property type="entry name" value="Ubl_TBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000100">
        <property type="entry name" value="inhibitor of nuclear factor kappa-B kinase subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.420:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000112">
        <property type="entry name" value="TANK binding kinase TBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041309">
        <property type="entry name" value="TBK1_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041087">
        <property type="entry name" value="TBK1_ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF14">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18394">
        <property type="entry name" value="TBK1_CCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18396">
        <property type="entry name" value="TBK1_ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO47707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="677" mass="77881" checksum="8CE2135F66DDA89C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PF95</accession>
    <name>A0A151PF95_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PF95"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7969" checksum="CDDDD1D8865FFBF9" modified="2016-06-08" version="1">MAWKLEIGGGWREKSMITWASRLVNRYLEDHLVNIECVYFWMTILRYLDLDFEGYSASALHFGCSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFT2</accession>
    <name>A0A151PFT2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0012750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000280">
        <property type="protein sequence ID" value="KYO47951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFT2"/>
    <dbReference type="STRING" id="8496.A0A151PFT2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF156">
        <property type="entry name" value="OLFACTORY RECEPTOR 52R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586991" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO47951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="92" mass="10335" checksum="DD6BFF1A91DB4765" modified="2016-06-08" version="1">MYLLLAMLAITDLVLSTSTVPKMLGFFWLDSREIGFHACLAQMFFSHAFSTVESDILMVMALDNYIAICYPLRHSSIHSIPMTKTIGSLMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFU3</accession>
    <name>A0A151PFU3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein FAM189B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FAM189BL</name>
        <name evidence="7" type="ORF">Y1Q_0009427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ENTREP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000340">
        <property type="protein sequence ID" value="KYO47890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFU3"/>
    <dbReference type="STRING" id="8496.A0A151PFU3"/>
    <dbReference type="KEGG" id="amj:102565353"/>
    <dbReference type="OrthoDB" id="9945596at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030431">
        <property type="entry name" value="ENTREP1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17615:SF7">
        <property type="entry name" value="PROTEIN ENTREP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17615">
        <property type="entry name" value="PROTEIN FAM189A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="239" mass="26036" checksum="4A7F44E76F55312F" modified="2016-06-08" version="1">MPSSSDSSHSLTGRSSRSLTHLRMQRTWLQILLVLGFIQVILGILIVTFSLVAATITPAPKIRHSCPYWAGFSLALSGLVGVVSWKRPVTVVITFFTLLSVLGVMLGLAGSILSCQNAQLVKSLEACEREMDMCMCCSVRSGLQHVPGPCSHHPDRLVMFANPDCRSIRMALKDLLFSICGLTIFSTIVCTLSAVMCCIQIFSLDVIHMVSTARSPLPCPHCTAEAWSRALHPPHTDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGT7</accession>
    <name>A0A151PGT7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Y+L amino acid transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0024683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000227">
        <property type="protein sequence ID" value="KYO48316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGT7"/>
    <dbReference type="STRING" id="8496.A0A151PGT7"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF213">
        <property type="entry name" value="Y+L AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54186" checksum="D7F623FC534BF789" modified="2016-06-08" version="1">MPEMDNVAENMEGKMKMKQEITLLNGVSLIVGNMIGSGIFVSPKGVLMYSGSYGLSLVLWAIGGIFSLFGALCYAELGTSIVKSGASFAYILEAFGAFIAFIRLWSSLLIIEPTTQAVIAITFANYIVQPVFPSCEPPYDAVRLIAAACICSITFINCVNVKWGTRVQDLFTYAKILALIVIIAVGLYKISQGETENLKTPFEGSTTDAGFIALGLYSALFSYSGWDTLNYVTEEMKNPERNLPISIAISMPIVAIIYLLTNIAYYVVLDMGTLLASDAVAVTFGNESLSYAKWIIPIAVAMSCYSGLNSSAIAASRLFYVGAREGHLPDSLSLIHVKCFTPVPALLFNGLMTLLYLLVEDVFLLINYYCFNYWLFVGLSIAGLIYLRYTQPDRPRPIKLSLFFPIVYCLCTIFLIMVPLYSDTVNSLIGIGIALSGIPVYYVGLYLPPEKRPRVLRRLSAMITKVQKQIGKMKFQLELHDAVSYFELDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHK5</accession>
    <name>A0A151PHK5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Y1Q_0018566</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000230">
        <property type="protein sequence ID" value="KYO48265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PHK5"/>
    <dbReference type="KEGG" id="amj:102570133"/>
    <dbReference type="eggNOG" id="KOG1933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PHK5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000010">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007587051" description="SSD domain-containing protein" evidence="17">
        <location>
            <begin position="26"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1102"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1128"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1157"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1198"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1231"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="624"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO48265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1281" mass="143241" checksum="484C17D6A5E8157A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIB5</accession>
    <name>A0A151PIB5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0022689</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000190">
        <property type="protein sequence ID" value="KYO48505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIB5"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001009">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF379">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="SCAN box" evidence="15">
        <location>
            <begin position="317"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="SCAN box" evidence="15">
        <location>
            <begin position="940"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1209"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO48505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1229" mass="139199" checksum="036D0CD4AAB9245D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYQ7</accession>
    <name>A0A151LYQ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Decorin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Bone proteoglycan II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DCN</name>
        <name evidence="17" type="ORF">Y1Q_0020035</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">May affect the rate of fibrils formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 14">Secreted</location>
            <location evidence="1 12 14">Extracellular space</location>
            <location evidence="1 12 14">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 14">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYQ7"/>
    <dbReference type="STRING" id="8496.A0A151LYQ7"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016352">
        <property type="entry name" value="SLRP_I_decor/aspor/byglycan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF14">
        <property type="entry name" value="DECORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002490">
        <property type="entry name" value="SLRP_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12 14" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRNT" evidence="16">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="25"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR002490-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO17415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="320" mass="35284" checksum="4CAECD8AC5EF3A8E" modified="2016-06-08" version="1">MVEDEGSADIPATEEPIFPGLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPSDTTLLDLQNNKITEIKEGDFKHLKDLHALILVNNKISKISPAAFAPLKKLERLYLSKNNLKELPENMPKSLQELRAHENEISKLRKVVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRISDSNITSIPRGLPPSLTELHLDGNKINKVDAESLTGLANLAKLGLSFNKITSVDNSTLANVPHLRELHLNNNELSKVPSGLAEHKYIQVVYLHNNKISSVGTNDFCPPGYNTKKASYSGKNLSSSVSSFHTMNRRDTQPSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYV6</accession>
    <name>A0A151LYV6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MRPL42</name>
        <name evidence="8" type="ORF">Y1Q_0020048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYV6"/>
    <dbReference type="STRING" id="8496.A0A151LYV6"/>
    <dbReference type="eggNOG" id="KOG4106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019346">
        <property type="entry name" value="Ribosomal_mL42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13450:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13450">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10210">
        <property type="entry name" value="MRP-S32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO17431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="224" mass="25350" checksum="8BD773BC90527CE0" modified="2016-06-08" version="1">MSGELRASTLLVELGLHFPACPGAAPALPEVGVAASGPGAAARGWRSDETCSFRRVTCSRKDTISLKYFSSSHFLLACSMAVAWKRATLFGNMWLRSAAFTRQAAVQNGAVHCARHKYSLVPEDYNCKVDLALTSDRRTIVCHHPSVEIPYEHTEPVPRPDPVNNKEETLDQVLKSRLEVKEMKNDKGPTIEELSKMFYTTKHRWYPVGQYHRRRKNYNFPKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZ22</accession>
    <name>A0A151LZ22_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone H1t</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HIST1H1T</name>
        <name evidence="6" type="ORF">Y1Q_0020083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZ22"/>
    <dbReference type="STRING" id="8496.A0A151LZ22"/>
    <dbReference type="eggNOG" id="KOG4012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000075">
        <property type="entry name" value="Histone H1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO17480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="203" mass="20383" checksum="E18AC1D475782158" modified="2016-06-08" version="1">MAEIAPVASPAVASPAAKAPAKKAKKAAGGSKAKKPAGPSVTELITQAVSASQDRKGLSLAALKKALAAGGYDVEKSNSRIKLGLKSLVNKGILVQTKGTGASGSFKLGKKPGETKAPKKAAAAKPKKPVAKKPKLPTAVKKSPKKAKKPAAGTAKKAAAKSPKKAKPVKAKKVVKSPAKAKAMKPKVAKPKATKASKAAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M103</accession>
    <name>A0A151M103_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSPB1-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">27 kDa heat shock protein-associated protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HSPBAP1-1</name>
        <name evidence="9" type="ORF">Y1Q_0011749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play a role in cellular stress response.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with CRYAB and HSPB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M103"/>
    <dbReference type="STRING" id="8496.A0A151M103"/>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000018">
        <property type="entry name" value="HSPB1-associated protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000343">
        <property type="entry name" value="HSPB1-associated protein 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013296">
        <property type="entry name" value="HSPB1-associated_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF43">
        <property type="entry name" value="HSPB1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01886">
        <property type="entry name" value="PASS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="8">
        <location>
            <begin position="142"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO18189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="414" mass="46939" checksum="7206CA10E299EFAF" modified="2016-06-08" version="1">MLQLLARLRTPDKAAAASTVLAPASCTPPRDLTHPIEKGEDVKPFTPEKAKAIVMSLQQPAVFCNMAFDWPALRWNPKYLSEMLDGKTIQFRLGMKKIDAAPQFETECSYVQATLEEFLAWSSGLSSCFSGPFSCYDSCKYWAYADYKYIAKIFEDKTEIFQDVIWSDFGFPGRNGRESTLWIGSVGANTPCHLDSYGCNLVLQVQGRKRWHLFPPSDACFLYPTRIPYEESSVFSKVSVVNPDLKRFPLFKKAKAHVVTLSPGQVLFVPQHWWHYVESIDPITISINSWIELDADHEARVEEAITRTLVCAIKSAEHPDSAGAWLNPTEVEATSHEINLQYLNGAMSAYLEYQKAGVLQHRYPSRHRTERTMSASCKRRKTQVMAEPEDNKEADFPTAKRQSLQADTYLQRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1C1</accession>
    <name>A0A151M1C1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0012795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006834">
        <property type="protein sequence ID" value="KYO18313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1C1"/>
    <dbReference type="KEGG" id="amj:102567787"/>
    <dbReference type="eggNOG" id="ENOG502RBZ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6144443at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15950">
        <property type="entry name" value="7tmA_OR52I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF179">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO18313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="316" mass="35353" checksum="CDB3FDFA3992DBD4" modified="2016-06-08" version="1">MSHYNHSNPSTFILKGIPGLETSHFWIAFPFCIMYCIALLGNLTILLVIKSEPSLHLPMYYFLCMLAGIDLVLTTATVPKILSIFWFQSHRICFHCCVVQMFFIHGFSAVESGVLLAMAFDRYVAISKPLHYTNMLTNSVIAKIGLAAVVRGIGLMTPLTCLVSSLHYCGSNIISHSYCEHMAVVKLACGDTTPNNIYGITAATFVVGSDSIFITVSYILILRAVMNLSSKEARLKSFGTCGSHVCVILVFFIPGLFSFYTQRWGQHIPTYLHILLADLYLLVPPMLNPIIYGMKTKQIWEHVPRLFCQKRFETGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3G5</accession>
    <name>A0A151M3G5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3G5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="9107" checksum="0DCB4A78A26E402A" modified="2016-06-08" version="1">MSLCLTFIQMRNSFHIISLYLELQSLPTIMEEVGTQNCTVHKTEAMAADVTGWPQLYEGTADDLRGFLPVFPLRRGSRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3L9</accession>
    <name>A0A151M3L9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 28A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC28A</name>
        <name evidence="2" type="ORF">Y1Q_0019015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267507.1">
        <property type="nucleotide sequence ID" value="XM_006267445.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3L9"/>
    <dbReference type="GeneID" id="102572098"/>
    <dbReference type="KEGG" id="amj:102572098"/>
    <dbReference type="CTD" id="25901"/>
    <dbReference type="eggNOG" id="ENOG502RYUK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9977011at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M3L9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400">
        <property type="entry name" value="CHEMOKINE C-C MOTIF RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 28A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="184" mass="20122" checksum="F855D54112C35C21" modified="2016-06-08" version="1">MEERKMKRRSPKASSAHPAPAAGAKKGALPSSKSTAFAPAVPQPAAQRPKLKRTTKEKAKPPATEGKGAQAAPIQHSFLTDVSDVQEMEKGLLSLLNDFHSGKLQAFGNECSIEQMEHVRSMQEKLARLNLELYGELEELPEDKRKIASDSNLDRLLSDLEELNSSIQKLHLADAQDIPNTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4K8</accession>
    <name>A0A151M4K8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maestro heat-like repeat-containing protein family member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MROH7</name>
        <name evidence="5" type="ORF">Y1Q_0003545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
        <property type="protein sequence ID" value="KYO19411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4K8"/>
    <dbReference type="STRING" id="8496.A0A151M4K8"/>
    <dbReference type="KEGG" id="amj:106737499"/>
    <dbReference type="OrthoDB" id="1884734at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF17">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="3">
        <location>
            <begin position="111"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="2">
        <location>
            <begin position="237"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="4">
        <location>
            <begin position="644"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO19411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="957" mass="108938" checksum="C59A06E9567C01DF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M614</accession>
    <name>A0A151M614_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform</fullName>
            <ecNumber evidence="6">2.7.1.153</ecNumber>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Serine/threonine protein kinase PIK3CB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">Y1Q_0021891</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:77137"/>
            <dbReference type="ChEBI" id="CHEBI:83243"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:43397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.153"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:21293"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Heterodimer of a catalytic subunit PIK3CB and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interaction with PIK3R2 is required for nuclear localization and nuclear export. Part of a complex with PIK3R1 and PTEN. Binding to PTEN may antagonize the lipid kinase activity under normal growth conditions. Part of a complex involved in autophagosome formation composed of PIK3C3 and PIK3R4. Interacts with BECN1, ATG14 and RAB5A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.153" evidence="6"/>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03006480">
        <property type="protein sequence ID" value="KYO19957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M614"/>
    <dbReference type="STRING" id="8496.A0A151M614"/>
    <dbReference type="eggNOG" id="KOG0904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046934">
        <property type="term" value="F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08693">
        <property type="entry name" value="C2_PI3K_class_I_beta_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00872">
        <property type="entry name" value="PI3Ka_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05173">
        <property type="entry name" value="PI3Kc_IA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000046">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000004">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000005">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.770:FF:000003">
        <property type="entry name" value="phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037702">
        <property type="entry name" value="PI3-kinase_beta_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF33">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00143">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51544">
        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0072">Autophagy</keyword>
    <keyword evidence="15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="27">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="29">
        <location>
            <begin position="190"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="30">
        <location>
            <begin position="330"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="28">
        <location>
            <begin position="525"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="26">
        <location>
            <begin position="773"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00065016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00068828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00080896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KYO19957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1071" mass="122525" checksum="07D745C9DB9B219F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M676</accession>
    <name>A0A151M676_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="13">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CYP21A2</name>
        <name evidence="22" type="ORF">Y1Q_0013783</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03006441">
        <property type="protein sequence ID" value="KYO20024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M676"/>
    <dbReference type="STRING" id="8496.A0A151M676"/>
    <dbReference type="KEGG" id="amj:102575314"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004509">
        <property type="term" value="F:steroid 21-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF17">
        <property type="entry name" value="STEROID 21-HYDROXYLASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20 21" id="KW-0349">Heme</keyword>
    <keyword evidence="8 20 21" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 21" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="12" id="KW-0755">Steroidogenesis</keyword>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KYO20024.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="320" mass="35416" checksum="E92157C2065D7C48" modified="2016-06-08" version="1">MMPSEAEIRDFTACITELVQLWSCISIQALDTVPLLRILPNPSLQRLLQVVEKRDAFVRAQIQRHQESLEPERPRDVVDHLLLAMGDLGPKRLHMALVDLFIGGTETTAALLAWACAFLVRHPEVQDRIHAELQDVLGPTAPLRPRDRDRLPLLSATLNETLRLRPPVPLALPHRTTRPTSVAGMSIPQDTIVIPNLFAAHHDETKWLEPEEFRPERFLAPGALRDLLPFSCGARACPGEALARAEALVTLGRLLREFRLEPAVLGTLPALNVVSFGIVLRCPSLCLRLVPRPRAPPPARGHTLVTPLPGVMTPLPGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6Q4</accession>
    <name>A0A151M6Q4_ALLMI</name>
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        <submittedName>
            <fullName evidence="13">RNA-binding protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RBM27</name>
        <name evidence="13" type="ORF">Y1Q_0010773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
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    <comment type="function">
        <text evidence="6">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014597614.3"/>
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    <dbReference type="eggNOG" id="KOG2135">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding motif protein 26"/>
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        <property type="entry name" value="RNA-binding protein 26 isoform X3"/>
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        <property type="entry name" value="PWI domain"/>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
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        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF1">
        <property type="entry name" value="RNA-BINDING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
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    </dbReference>
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    <keyword evidence="1 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="560"/>
            <end position="634"/>
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    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="919"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
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            <end position="337"/>
        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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    <feature type="region of interest" description="Disordered" evidence="10">
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    <feature type="region of interest" description="Disordered" evidence="10">
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="711"/>
            <end position="749"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="752"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
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            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO20213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1033" mass="116643" checksum="9AE782C7B961087F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6U7</accession>
    <name>A0A151M6U7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Interferon regulatory factor 1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IRF1</name>
        <name evidence="11" type="ORF">Y1Q_0010802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6U7"/>
    <dbReference type="STRING" id="8496.A0A151M6U7"/>
    <dbReference type="eggNOG" id="ENOG502QVVN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00103">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000065">
        <property type="entry name" value="Interferon regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019817">
        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF3">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00601">
        <property type="entry name" value="IRF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="10">
        <location>
            <begin position="117"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO20252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="430" mass="48627" checksum="1C26BC8EB2115356" modified="2016-06-08" version="1">MSFSCRPCSSSHPVALGIKKEKKKGEIPAVCVIGPALSLEGSEDQNLNKAPSANLRCEDLGEQNANELDSSKVIHKHVNKKTRAQPAAGTERCAALRAGTHRPTDRRAHTDKMPVTRMRMRPWLEMQINSNQIPGLTWINKDKMMFQIPWKHAAKHGWDMEKDACLFRSWAVHTGRYKIGEKEPDPKTWKANFRCAMNSLPDIEEVKDKSINKGSSAVRVYRMLPPLTKLQKKERKSKSSRDSRNKSRRKSYEDMRSDEAVEALNSTMIPDDHSSYTVQDYAGQEVKVESTSVTLDLSPCDIHAAVTEWRTPMEIALADSTNDIYQLQVSPLASSSEVTDEDQEEIKSDLFKLLEQDWHTTSIGGKGYLTNEPGTQSLCSYMYKEQDAEIDTTSEEIELRLCTDMKSSSLEFSWLETVRSSNMQAIPCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M826</accession>
    <name>A0A151M826_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trichohyalin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M826"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="529" mass="60568" checksum="9AB6290C5EC711D4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M902</accession>
    <name>A0A151M902_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Selenoprotein S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">VIMP</name>
        <name evidence="13" type="ORF">Y1Q_0001318</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the selenoprotein S family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO20996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M902"/>
    <dbReference type="STRING" id="8496.A0A151M902"/>
    <dbReference type="GeneID" id="102562724"/>
    <dbReference type="KEGG" id="amj:102562724"/>
    <dbReference type="CTD" id="55829"/>
    <dbReference type="eggNOG" id="ENOG502RXYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75792at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M902"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036513">
        <property type="term" value="C:Derlin-1 retrotranslocation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036502">
        <property type="term" value="C:Derlin-1-VIMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009703">
        <property type="entry name" value="Selenoprotein_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28621">
        <property type="entry name" value="SELENOPROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28621:SF1">
        <property type="entry name" value="SELENOPROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06936">
        <property type="entry name" value="Selenoprotein_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO20996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="189" mass="20339" checksum="8F9945DC3EA3E4C5" modified="2016-06-08" version="1">MELGGGAPGPGQPDVEHGGLHLLPRAVGALLSAYGWYLLLACVAIYLLVQKVSESARARRRSRPDPPGAAAEPDAVVRRQEALAAARLKMQEELNAQAEKYKEKQRELEEEKRRQKIAMWESMQEGKSYKGNLKLNQQETASSPSTSSAVPKPKPDKKPLRGGGYNPLSGEGGGACSWRPGRRGPSAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M943</accession>
    <name>A0A151M943_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M943"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="10670" checksum="5A0BDD86BECD99A8" modified="2016-06-08" version="1">MTLIEYYHTSLSYCLSDAPYIHQTEGFIDFRLSEQPFSGNGLTSGHQKPDLALTTDLERKRMRLLCHRCFQEQSAASFCRNFVSPLMAFQSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9H2</accession>
    <name>A0A151M9H2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SHC-transforming protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0001458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M9H2"/>
    <dbReference type="eggNOG" id="ENOG502QT0E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01209">
        <property type="entry name" value="PTB_Shc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09925">
        <property type="entry name" value="SH2_SHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000036">
        <property type="entry name" value="SHC-transforming protein 1 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000005">
        <property type="entry name" value="SHC-transforming protein 1 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051235">
        <property type="entry name" value="CEP152/SHC-Transforming"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057659">
        <property type="entry name" value="CEP152_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057664">
        <property type="entry name" value="CEP152_PLK4_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006019">
        <property type="entry name" value="PID_Shc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035676">
        <property type="entry name" value="SHC_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337:SF6">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 152 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337">
        <property type="entry name" value="SHC TRANSFORMING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25770">
        <property type="entry name" value="CC_CEP63-bind_CEP152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25769">
        <property type="entry name" value="PLK4_bind_CEP152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00629">
        <property type="entry name" value="SHCPIDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="102"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="442"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2342"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="800"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1103"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1259"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1496"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1550"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1620"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1817"/>
            <end position="1886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO21178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2361" mass="269373" checksum="8357B097B48CA4E7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB11</accession>
    <name>A0A151MB11_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-retinol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.300</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RDH12</name>
        <name evidence="9" type="ORF">Y1Q_0000426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25033"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.300"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; retinol metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.300" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MB11"/>
    <dbReference type="STRING" id="8496.A0A151MB11"/>
    <dbReference type="GeneID" id="102567292"/>
    <dbReference type="KEGG" id="amj:102567292"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MB11"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000145">
        <property type="entry name" value="Retinol dehydrogenase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004846">
        <property type="entry name" value="PRK06197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF32">
        <property type="entry name" value="RETINOL DEHYDROGENASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO21705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="319" mass="35369" checksum="20B6B471662EA39C" modified="2016-06-08" version="1">MMLLILGTLLGIIFGPALFILVPYIRNYFAGAVCKSKAKLNGKVVLITGANTGIGKETARDLAKRGARVILACRDTAKGEVAACEIRAETGNQQVIMKKLDLADTKSIRQFAENFLAEEKELHILINNAGVMLYPYAKTADGFEMHLGVNHLGHFLLTFLLLERLKQSAPARIVNVSSLAHLVGRIRFHDLQGEKFYQRGLAYCQSKVANVHFTRELARRLQGTGVTVNALHPGTVQSELTRYSSVVSLLWKMFSFFLKTPQEGAQTSIYCAVAEELESVTGQYFSDCQPAYVSAHGRDDETAKKLWKVSCELLGIQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB34</accession>
    <name>A0A151MB34_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pleckstrin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PLEK2</name>
        <name evidence="14" type="ORF">Y1Q_0000431</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell projection</location>
            <location evidence="10">Lamellipodium membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266494.1">
        <property type="nucleotide sequence ID" value="XM_006266432.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MB34"/>
    <dbReference type="STRING" id="8496.A0A151MB34"/>
    <dbReference type="GeneID" id="102567071"/>
    <dbReference type="KEGG" id="amj:102567071"/>
    <dbReference type="CTD" id="26499"/>
    <dbReference type="eggNOG" id="ENOG502QYJ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031258">
        <property type="term" value="C:lamellipodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04444">
        <property type="entry name" value="DEP_PLEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13301">
        <property type="entry name" value="PH1_Pleckstrin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000312">
        <property type="entry name" value="Pleckstrin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000208">
        <property type="entry name" value="Pleckstrin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000243">
        <property type="entry name" value="Pleckstrin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037369">
        <property type="entry name" value="PLEK2_DEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF2">
        <property type="entry name" value="PLECKSTRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="13">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="249"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO21711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="355" mass="40521" checksum="44F3E7275E7805AD" modified="2016-06-08" version="1">MEEASGVLRKGFLVKRGHIVHNWKVRWFVLLQDKLLYYKIEGGRKEPPPKGRILLDGCTITCPCLEYENRPLVIKLKTKTNTEYFLESCSREERDSWALDITGAIHAGHPVQVQHLHRMKNSFKLPSNISLNHIVDKMHDNSCGIKMTPNVEQGNTYKETFTGSAVVDWLISNNFSASRLEAVTLASMLMEENFIRPIGARSTEAMRSGNLAEQFLDDSTALYLFAESYKKKTNSKEDMHLSILELSGTIVKQGYLVKQGHKRKNWKVRRFVLRSEPAFLHYYDPTKEENRPVGGFSLRSCLVSALEDNGVPTGVKGNVQGNLFKIITKNDIHYYIKASSKAERTQWIEAIKRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEW9</accession>
    <name>A0A151MEW9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEW9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7938" checksum="6F3FA358F7D05E57" modified="2016-06-08" version="1">MRRPSGRRAVILVLRALQSCESSLRRTGILKDQEQRFAYCCHHWRANFFNESAFPLWSCGVKGPKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MG19</accession>
    <name>A0A151MG19_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-14</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">RAB14</name>
        <name evidence="24" type="ORF">Y1Q_0005807</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Early endosome membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059571690.1">
        <property type="nucleotide sequence ID" value="XM_059715707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MG19"/>
    <dbReference type="SMR" id="A0A151MG19"/>
    <dbReference type="STRING" id="8496.A0A151MG19"/>
    <dbReference type="GeneID" id="102576300"/>
    <dbReference type="KEGG" id="amj:102576300"/>
    <dbReference type="CTD" id="51552"/>
    <dbReference type="eggNOG" id="KOG0097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MG19"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090382">
        <property type="term" value="P:phagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04122">
        <property type="entry name" value="Rab14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000344">
        <property type="entry name" value="Ras-related protein Rab-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030702">
        <property type="entry name" value="Rab14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO23451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="215" mass="23897" checksum="BC8A8B98FB9944AC" modified="2016-06-08" version="1">MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MG58</accession>
    <name>A0A151MG58_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger protein 865</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF865</name>
        <name evidence="15" type="ORF">Y1Q_0010076</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006198">
        <property type="protein sequence ID" value="KYO23505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MG58"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="852"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="936"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="964"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="112"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO23505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="999" mass="109558" checksum="9FAC2191C7DA29BF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGI9</accession>
    <name>A0A151MGI9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0002271</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGI9"/>
    <dbReference type="STRING" id="8496.A0A151MGI9"/>
    <dbReference type="KEGG" id="amj:102558962"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MGI9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF6">
        <property type="entry name" value="POLY(A) POLYMERASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="20">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="19">
        <location>
            <begin position="217"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="18">
        <location>
            <begin position="364"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="676"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO23634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="741" mass="83699" checksum="65BEE854470CDCF5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIE7</accession>
    <name>A0A151MIE7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIE7"/>
    <dbReference type="STRING" id="8496.A0A151MIE7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="193" mass="21233" checksum="E9A1DB61022521B5" modified="2016-06-08" version="1">MLGLGPCTASAHTLSETSSFTTGGVTELDTDSQRYVLALPEEETWRKHRLGLMQTTQSCNLLEPESLTEALVSRTASFDALYELRSREGEGSLGFEGGSTFDLGLSQYIPVSPDVIKRRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEAGVSLKISSTLEEEMQPSFNAGGSWILFCHVAEGRGKDQESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIZ7</accession>
    <name>A0A151MIZ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Y1Q_0002115</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006071">
        <property type="protein sequence ID" value="KYO24508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIZ7"/>
    <dbReference type="STRING" id="8496.A0A151MIZ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05066">
        <property type="entry name" value="PTKc_EphR_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000041">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000019">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000045">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF13">
        <property type="entry name" value="EPHRIN TYPE-A RECEPTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00791">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Eph LBD" evidence="25">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="301"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="412"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="621"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="23">
        <location>
            <begin position="911"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="627"/>
            <end position="635"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="46"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO24508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="971" mass="108318" checksum="F42AF65014518626" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJ52</accession>
    <name>A0A151MJ52_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJ52"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8231" checksum="75DA7B06A3B34C2F" modified="2016-06-08" version="1">MQLYWRRDAGPDEGQESRGACVLEERLAHAWWGLANSSTVAELHEGAQKGGGQGSYVGSHRARGIQQGQLVHAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ML06</accession>
    <name>A0A151ML06_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0013884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005912">
        <property type="protein sequence ID" value="KYO25216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ML06"/>
    <dbReference type="STRING" id="8496.A0A151ML06"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005131">
        <property type="term" value="F:growth hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060397">
        <property type="term" value="P:growth hormone receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041155">
        <property type="entry name" value="FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041046">
        <property type="entry name" value="FERM_F2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE JAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18379">
        <property type="entry name" value="FERM_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18377">
        <property type="entry name" value="FERM_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="58"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO25216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="225" mass="24348" checksum="F23EE2C91E0079A9" modified="2016-06-08" version="1">MGADSALRCAPDRGRADSTSAPKQCGDTPGACPTMAPLGEDTPLMGHCSSSLSSTEAGMLQVHLYHQPGTPNSSGTLTFSFGEYLAEELCVAAAKACGILPVCHCLFALATEDLSGWYPPNHVFTVSDATTLVVVYRIRFLFPNWCGPGKSQRFQLLQDRASAVLDQPVIDYLFAQSRSDFLRGLVAGVLSWQTLEACLCLAVLDMLRIAKERRQSLDHVFSCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ML28</accession>
    <name>A0A151ML28_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005903">
        <property type="protein sequence ID" value="KYO25245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ML28"/>
    <dbReference type="STRING" id="8496.A0A151ML28"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="232" mass="26540" checksum="67944EA816B71923" modified="2016-06-08" version="1">MQERPLVARHNIPLTEDKAKIAEAARQSALEILRDALKKKDRVLMETPQDLISRDSEEPMLWMERYAVLMEQWVRDLISVLEKAKFMENPSTQQLYTYVYTESGDKAIYLCPLFWAAPRHLDKDSQPGTLIHKASHFLGTCDITYEPFSFYVTCRGVMVKNSSTDPDSPKFLPLVTAVLNANNIQHKFERTLRHRGDYKQGRYSCCGETARSSVCESAVPDAFLVCRNNGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLV0</accession>
    <name>A0A151MLV0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Golgin subfamily A member 7B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GOLGA7B</name>
        <name evidence="6" type="ORF">Y1Q_0011818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005754">
        <property type="protein sequence ID" value="KYO25506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLV0"/>
    <dbReference type="STRING" id="8496.A0A151MLV0"/>
    <dbReference type="eggNOG" id="KOG4069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF2">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="5">
        <location>
            <begin position="46"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO25506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="170" mass="18745" checksum="FD6D1D6224C57329" modified="2016-06-08" version="1">MFSLWKRHTWLGDDEKSCSPAQRVLGDRAQRQEKEAELAGAWCCQEVKGTGIERQLFEETVKTLNNYYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISKFIQEQNEKIYAPRGLLLTDPLERGMRVIEISIYEDRCSSGSSSSSSSSSSSGGGGGGAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMZ3</accession>
    <name>A0A151MMZ3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytosolic carboxypeptidase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP/GTP-binding protein-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Protein deglutamylase CCP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">AGBL2</name>
        <name evidence="22" type="ORF">Y1Q_0012262</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:60004"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:60005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005659">
        <property type="protein sequence ID" value="KYO25892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMZ3"/>
    <dbReference type="STRING" id="8496.A0A151MMZ3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06907">
        <property type="entry name" value="M14_AGBL2-3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF41">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 22" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="21">
        <location>
            <begin position="341"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="838"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO25892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="866" mass="98980" checksum="76CC3918D1423BCE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNS2</accession>
    <name>A0A151MNS2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNS2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="94" mass="10750" checksum="153780A73B5131DF" modified="2016-06-08" version="1">MTSTPAVDNFYQAQVCQLGCKPALGWASRKASSRPPFGMLLNTGHLDEEERAVYTEYLASGYLAPKFVRVKHPDPNMTWIKREKSWRRLLEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNY9</accession>
    <name>A0A151MNY9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline-rich protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005608">
        <property type="protein sequence ID" value="KYO26261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNY9"/>
    <dbReference type="eggNOG" id="KOG1701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="120" mass="12361" checksum="7EF9A31BFAD549E3" modified="2016-06-08" version="1">MSGPTWLPPKLAGGSPQPPRTVPTGPLETNGTPAPGAPNPRYPEVPRAGRIGYTMQGSTPDRGASIDDQIDSLTTMLADLESAAPSRWGGARQVQTLLDGGGVGQRKRLLDFGGGGKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MP37</accession>
    <name>A0A151MP37_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005656">
        <property type="protein sequence ID" value="KYO26189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MP37"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="81" mass="8856" checksum="BDDD94EDF6254562" modified="2016-06-08" version="1">MLGQAAEDLSPKKELLTCAAIFPLFLQNQLLLFEATEAAVTSLGLLGLALPLFLTPYTALVLLSSSSLQSRRLNYLFKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MP46</accession>
    <name>A0A151MP46_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Dysbindin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DTNBP1</name>
        <name evidence="18" type="ORF">Y1Q_0002007</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Synaptic vesicle membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Melanosome membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dysbindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005656">
        <property type="protein sequence ID" value="KYO26199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270681.1">
        <property type="nucleotide sequence ID" value="XM_006270619.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MP46"/>
    <dbReference type="STRING" id="8496.A0A151MP46"/>
    <dbReference type="GeneID" id="102561562"/>
    <dbReference type="KEGG" id="amj:102561562"/>
    <dbReference type="CTD" id="84062"/>
    <dbReference type="eggNOG" id="ENOG502QRS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2445127at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060155">
        <property type="term" value="P:platelet dense granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007531">
        <property type="entry name" value="Dysbindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16294:SF5">
        <property type="entry name" value="DYSBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16294">
        <property type="entry name" value="DYSTROBREVIN BINDING PROTEIN 1 DYSBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04440">
        <property type="entry name" value="Dysbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="256"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="110"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO26199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="352" mass="39856" checksum="91983D75DEB79B0A" modified="2016-06-08" version="1">MLETLRERLLSVQQDLASGLKTLGDKSREVKESKQRSVEFLPKFSAGLELLSRYEDMWAALHRGAKECAKAGELVDSEVVMLSAHWEKKRSSLIELQEQLQQIPGFLADLESMTTSLAQLEANFEEMENHLLRLEDLCGQCELERYKHIQALQLESYKKTKRNELETFKAELDAEHAQKVLDMEHTQQMKLRERQKFFEEAFQQDMEQYLSTGYLQIAERREPIGSMSSMEVNVDMLEQMDLMDMSDQEALDVFLNSGGEDNSMLSPVLGPDSDTYPTEISLPVPSQSELRQKWSSLSSTCTDSASQDASEGESPVIQSDEEEIQVDTALAAVNTERKSTSDGSDESDSQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPS6</accession>
    <name>A0A151MPS6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leptin receptor overlapping transcript-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LEPROTL1</name>
        <name evidence="9" type="ORF">Y1Q_0002143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270136.1">
        <property type="nucleotide sequence ID" value="XM_006270074.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPS6"/>
    <dbReference type="STRING" id="8496.A0A151MPS6"/>
    <dbReference type="GeneID" id="102566079"/>
    <dbReference type="KEGG" id="amj:102566079"/>
    <dbReference type="CTD" id="23484"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MPS6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060400">
        <property type="term" value="P:negative regulation of growth hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF4">
        <property type="entry name" value="LEPTIN RECEPTOR OVERLAPPING TRANSCRIPT-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO26512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="131" mass="14318" checksum="D12B0622F6B91CA1" modified="2016-06-08" version="1">MAGIKALISLSFGGAIGLMFLMLGCALPQYSKYWPLFVLFFYILSPIPYCIARRVVDDTDAASNACKELAIFLTTGIVVSAFGLPIVFARAELILWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSJ1</accession>
    <name>A0A151MSJ1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Y1Q_0003649</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MSJ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001895">
        <property type="term" value="P:retina homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000072">
        <property type="entry name" value="Cyclic nucleotide gated channel beta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000020">
        <property type="entry name" value="Cyclic nucleotide-gated channel beta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF16">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="8" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="1005"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="488"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="620"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1186"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1311"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1345"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO27483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1366" mass="154075" checksum="70AB17193EB3DA0A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSN5</accession>
    <name>A0A151MSN5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PDPR</name>
        <name evidence="9" type="ORF">Y1Q_0003674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSN5"/>
    <dbReference type="STRING" id="8496.A0A151MSN5"/>
    <dbReference type="eggNOG" id="KOG2844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000046">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000003">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000004">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF15">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO27521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="859" mass="96864" checksum="2850244F0EF0438E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTB4</accession>
    <name>A0A151MTB4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTB4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7474" checksum="A2924B325DABA72F" modified="2016-06-08" version="1">MAVGAVLTQEEGDNERPMAYTICKLLLAEKRPDWRPRKLRKGTDQSNRATTSRVPRCVSSGIRPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTL3</accession>
    <name>A0A151MTL3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0739 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005066">
        <property type="protein sequence ID" value="KYO27852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTL3"/>
    <dbReference type="STRING" id="8496.A0A151MTL3"/>
    <dbReference type="eggNOG" id="ENOG502RZ46">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027850">
        <property type="entry name" value="DUF4504"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31366">
        <property type="entry name" value="UPF0739 PROTEIN C1ORF74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31366:SF2">
        <property type="entry name" value="UPF0739 PROTEIN C1ORF74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14953">
        <property type="entry name" value="DUF4504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="188" mass="21131" checksum="CBC475CDE58788D7" modified="2016-06-08" version="1">MGLTRHPLHLLSIADNILILNLEKTVLHLESLLLMNKVLLVDVSASRKCPQPCEPEHVDSLKGHISDLLAHVKAAERVASQPVSTSQIFSADWNLCTMFGVLLGYPAFYAFNAEKGFENCLSLTPLRVFTVQASCPRISKDLRVRIYSFSVPENLYPAMKEELDLWNALLNLSDPSCHRLSTLNRSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTM0</accession>
    <name>A0A151MTM0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005066">
        <property type="protein sequence ID" value="KYO27857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTM0"/>
    <dbReference type="STRING" id="8496.A0A151MTM0"/>
    <dbReference type="eggNOG" id="ENOG502QQKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35077">
        <property type="entry name" value="SIMILAR TO AI661453 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35077:SF2">
        <property type="entry name" value="SIMILAR TO AI661453 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="922" mass="98483" checksum="BC2B7EFAACCF300F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV85</accession>
    <name>A0A151MV85_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV85"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9490" checksum="6D430DE0ADEA6A9C" modified="2016-06-08" version="1">MQPDSLAQKRWKMHRKRLSKRLPAAVTQPPISLQGQLTLDMAQVVPRPHTGFFFKEQFLLYVALQKQADLHLGTAAGRPNLIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVN8</accession>
    <name>A0A151MVN8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TDH</name>
        <name evidence="8" type="ORF">Y1Q_0005352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03004889">
        <property type="protein sequence ID" value="KYO28555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVN8"/>
    <dbReference type="STRING" id="8496.A0A151MVN8"/>
    <dbReference type="eggNOG" id="KOG2774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05272">
        <property type="entry name" value="TDH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000077">
        <property type="entry name" value="L-threonine 3-dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO28555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="346" mass="39210" checksum="C0E515EDA27DACA6" modified="2016-06-08" version="1">MLLITGYLKEQDDSHQEFEQSHRPETDHPRVLITGGLGQLGVGLAKLLRKRFGKNNVILSDIRKPADNVFYSGPFIYSDILDYKNLREIVVNNRITWLIHYSALLSAVGEANVPLARAVNITGLHNILDIAAEHSLRLFVPSTIGAFGPTSPRNPTPDLCIQRPRTIYGVSKVHAELMGEYYHYRYGLDFRCLRYPGIISADSQPGGGTTDYAVQVFHDAIKTGKFQCNLKPDTRLPMMYIDDCLKATLEVMEAPAELLTMRTYNINAMSFTPEELVQEVQKHVPEFEVTYNVDPVRQAIADSWPMNFDDNNARKDWGWKHDYDLPELVTTMFNFLGSESRIAQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVV6</accession>
    <name>A0A151MVV6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0011407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004884">
        <property type="protein sequence ID" value="KYO28578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVV6"/>
    <dbReference type="STRING" id="8496.A0A151MVV6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF7">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="339"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO28578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="631" mass="70079" checksum="8CA90E35760321B9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MW54</accession>
    <name>A0A151MW54_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004838">
        <property type="protein sequence ID" value="KYO28669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MW54"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="136" mass="15025" checksum="A505CA4F47EDFFD3" modified="2016-06-08" version="1">MQSWAWGHGVETCTEAVTLAEGFQLEPAEDKKLQVPVNVMVEEVSSDEVQEPVDCNGEQPKAHSADMPLEEAGQTEMLGPQDKPPLVPEEPLHCQESDGGLRTAREQGRVRESSLINARWLLEHASPWTHQSCGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWY3</accession>
    <name>A0A151MWY3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWY3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8394" checksum="ECA81DF94D49DCD7" modified="2016-06-08" version="1">MGETMQTSMLMVMSIYQTIQIINPSNCDLEGAQVCKLCPASGIKLLQTELTGLETRLKMHFESKNATGIKSGMKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXB2</accession>
    <name>A0A151MXB2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TRAPPC13</name>
        <name evidence="7" type="ORF">Y1Q_0009962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPPC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXB2"/>
    <dbReference type="STRING" id="8496.A0A151MXB2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055428">
        <property type="entry name" value="TRAPPC13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23643">
        <property type="entry name" value="TRAPPC13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="6">
        <location>
            <begin position="187"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 C-terminal" evidence="5">
        <location>
            <begin position="323"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO29186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="427" mass="47922" checksum="CB0277D0CB54623C" modified="2016-06-08" version="1">MDVNQPKQEHLLALKGPVFFRSVQHMARKDLMRLTKPTLFTNVPVTCEERDLPGDLFNQLMKEDPSTVKGAETLMLGEMLTLPQNFGNIFLGETFSSYISVHNDSNQVVKDILVKADLQTSSQRLNLSASSAAVAELKPDCCIDDVIHHEVKEIGTHILVCAVSYTTQAGEKMYFRKFFKFQVLKPLDVKTKFYNAETDEVFLEAQIQNITTSPMFMEKVSLEPSIMYNVAELNTVNKAGESISTFGSRTYLQPMDTRQYLYCLKPKQEFAEKAGVIKGVTVIGKLDIVWKTNLGERGRLQTSQLQRMAPGYGDVRLSLETIPDTVNLEEPFDITCKITNCSSERTMDLILEMCNTNSIHWCGVSGRQLGKLHPSSSLHLALTLLSSVQGLQSVSGLRLTDTFLKRTYEYDDIAQVCVVSSEVKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MY36</accession>
    <name>A0A151MY36_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING finger protein 151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0018045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MY36"/>
    <dbReference type="STRING" id="8496.A0A151MY36"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO29437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="268" mass="31335" checksum="E86F902D963C8D8E" modified="2016-06-08" version="1">MPLVTHILQVETLWKRMGFDIERFVGYVNEGLLCSICRDVLEDPLQAPCEHAFCTTCIHGWLVHHSNCPEDRQALDASVLHPLYRYMKNDLNRLQLHCKNREHGCDMVCSLESIDRHERECEYGQISCSNAGCPVQVERRNLDSHLALCEYRSRECPNGCGYTVLSTEDTQHNCVAELRTELELLRSEMICRVEEAKHEMESRLDSQRRHMVQKESMLQNEIEELKSQMSRMMSDVRSLLAAERQHRQELEQAELEKRKLPSSKKKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZQ5</accession>
    <name>A0A151MZQ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004379">
        <property type="protein sequence ID" value="KYO29990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZQ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="7860" checksum="ADEFCCFAD3BA8CB6" modified="2016-06-08" version="1">MKSHAKQRPWQGRWRLSSEAIPPSVHHGDQLDITNKKSLGLSCVVRDLSKDEGATLLSEVGEKLFSGVFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0B5</accession>
    <name>A0A151N0B5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004278">
        <property type="protein sequence ID" value="KYO30180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0B5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="11928" checksum="23392DBE5DDEEDE3" modified="2016-06-08" version="1">MVEEWLAGSWVWSMENTVHEWERDRLLTLKVRHITLLKRMLEAQEQQVTMVARAVKAVKEDHLMLDSILALEVTFVSPTTQPLALALPAPWQLPAAQLQASQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0B8</accession>
    <name>A0A151N0B8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004278">
        <property type="protein sequence ID" value="KYO30251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0B8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9971" checksum="DB960EC4806983DD" modified="2016-06-08" version="1">MILESCSLHLKLESAINVPPPYQSQAQSESEEVQRRSPTAGWFTEPELTQDMTGYHVLFGLLHCSKKRWICKRINFLTNATSIAKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2K6</accession>
    <name>A0A151N2K6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0016379</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2K6"/>
    <dbReference type="STRING" id="8496.A0A151N2K6"/>
    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="839"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="670"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="751"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="809"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="968"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="968"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO30990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1150" mass="128420" checksum="6F09604D522EC6C1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3K7</accession>
    <name>A0A151N3K7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">ITGB4</name>
        <name evidence="27" type="ORF">Y1Q_0016501</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="23">Cell junction</location>
            <location evidence="23">Hemidesmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 24">Cell membrane</location>
            <topology evidence="2 24">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 24">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N3K7"/>
    <dbReference type="eggNOG" id="KOG1226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000212">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000215">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000287">
        <property type="entry name" value="Integrin beta"/>
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    </dbReference>
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        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000004">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040622">
        <property type="entry name" value="EGF_integrin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057073">
        <property type="entry name" value="EGF_integrin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033760">
        <property type="entry name" value="Integrin_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012896">
        <property type="entry name" value="Integrin_bsu_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036349">
        <property type="entry name" value="Integrin_bsu_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF42">
        <property type="entry name" value="INTEGRIN BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23105">
        <property type="entry name" value="EGF_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18372">
        <property type="entry name" value="I-EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07965">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17205">
        <property type="entry name" value="PSI_integrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01242">
        <property type="entry name" value="Integrin_B_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69687">
        <property type="entry name" value="Integrin beta tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52047">
        <property type="entry name" value="I_EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 24" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="14" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 24 27" id="KW-0401">Integrin</keyword>
    <keyword evidence="22" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 24 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="1172"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="1265"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="1538"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="1651"/>
            <end position="1747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00060371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO31159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1833" mass="206039" checksum="6684BF12CA3F8D30" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N461</accession>
    <name>A0A151N461_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Exosome complex component 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">EXOSC10</name>
        <name evidence="30" type="ORF">Y1Q_0006059</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="23">Component of the RNA exosome complex. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6 (via its N-terminus). Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. The RNA exosome complex interacts with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with MTREX; the interaction with MTREX mediates the association of MTREX with nuclear RNA exosomes. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with ALYREF/THOC4. Interacts with DHX36; this interaction occurs in a RNase-insensitive manner. Interacts with NRDE2. Interacts (via C-terminus) with USP36 (via C-terminus); the interaction is facilitated by the association with RNA and promotes sumoylation of EXOSC10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 26">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003836"/>
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    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KYO31477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1132" mass="128710" checksum="ACD11D09E18E7C9F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4K1</accession>
    <name>A0A151N4K1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbonic anhydrase</fullName>
            <ecNumber evidence="13">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CA6</name>
        <name evidence="17" type="ORF">Y1Q_0006091</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Reversible hydration of carbon dioxide. Its role in saliva is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4K1"/>
    <dbReference type="STRING" id="8496.A0A151N4K1"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03125">
        <property type="entry name" value="alpha_CA_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000003">
        <property type="entry name" value="Carbonic anhydrase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF110">
        <property type="entry name" value="CARBONIC ANHYDRASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="15">
        <location>
            <begin position="9"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="16">
        <location>
            <begin position="312"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO31519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="510" mass="57727" checksum="FCF56C6CAE9901B1" modified="2016-06-08" version="1">MHLSSSHITHWTYKEGELDEEHWGRHFADCAGKHQSPIDIQKRKVRYNPQLMELELSGYDGPLQGNFTMTNNGHSVQIDLPPTMRITKGLPSLFTAVQMHLHWGGLDLETSGSEHTIDGMRYFAELHIVHYNSGNYSSFEEAKDKPNGLAVLAFLYVDGHFENTYYSKFISNLAKIRYAGQSMRLTSLDVQGMLPENLSHFYRYPGSLTTPPCSESVIWTVFDSPIILSPTQIKLLENTLLDWQNKTLRNDYRHAQPLNDRVVESSFKAKVEQEICHLEELSLKLEQIQAQLQDMKKHLLGGVHLRGAQSSAFPAFFFPADNIESYVNVRPRHVMRLHSFTLCFWIQTQNLGSQTVLSYSTPESDNELVVTVGSDVGLWVGGHFTNFFLHHRSEEWLHYCVSWTSHSGTADLWINGAVGREKSIQKGYVTQAGGTLVLGKDRDNLLGIFSNRFIGRMSHVNLWNKVLSHADIRALALCKHNELRGDVIAWGETPMSVSGGVVLETDSSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4R7</accession>
    <name>A0A151N4R7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">RNA-binding protein EWS isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">EWSR1</name>
        <name evidence="16" type="ORF">Y1Q_0022857</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM TET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449103.1">
        <property type="nucleotide sequence ID" value="XM_014593617.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4R7"/>
    <dbReference type="STRING" id="8496.A0A151N4R7"/>
    <dbReference type="GeneID" id="102561474"/>
    <dbReference type="KEGG" id="amj:102561474"/>
    <dbReference type="CTD" id="2130"/>
    <dbReference type="eggNOG" id="KOG1995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76445at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12533">
        <property type="entry name" value="RRM_EWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000127">
        <property type="entry name" value="RNA-binding protein EWS isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000002">
        <property type="entry name" value="RNA-binding protein EWS isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034869">
        <property type="entry name" value="EWS_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034870">
        <property type="entry name" value="TET_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23238">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="361"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="122"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="446"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="550"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO31788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="662" mass="68985" checksum="4630596C30E29E03" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4Y5</accession>
    <name>A0A151N4Y5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rano class II histocompatibility antigen, A beta chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0003423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004037">
        <property type="protein sequence ID" value="KYO31858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4Y5"/>
    <dbReference type="STRING" id="8496.A0A151N4Y5"/>
    <dbReference type="KEGG" id="amj:102576197"/>
    <dbReference type="eggNOG" id="ENOG502RYBQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9940220at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002504">
        <property type="term" value="P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05766">
        <property type="entry name" value="IgC1_MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000116">
        <property type="entry name" value="HLA class II histocompatibility antigen, DRB1-1 beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000353">
        <property type="entry name" value="MHC_II_b_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF99">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1 BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00969">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00921">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0491">MHC II</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="124"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO31858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="281" mass="31913" checksum="7BAF872B137E5B47" modified="2016-06-08" version="1">MVSAGIAGAGCTGALIVIIALRVNKAHCTEPPEHFLLQENHECHYVNGTQQARYVERVIWGQQEICYYDSDVGYYVARTEEGQWIAEYRNRLEYLSFLWASVEKFCSYSYRRFKSVAMDRKVKPKIKIYPMKTESSHTPNLLVCSVTRFYPSGIRVKWLKNGQEHTGNVVSSELLPNGDWTFQMHVKLKMVPRRGDVYACQVDHISLQTPMTLQWEVQTYSAKSKMIAGIVSLVLGLMLIMVGLVLYLKNGEGCPWPAAAQSWDADMRSGISTTHLLEDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N621</accession>
    <name>A0A151N621_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SMG8</name>
        <name evidence="6" type="ORF">Y1Q_0007213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SMG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N621"/>
    <dbReference type="STRING" id="8496.A0A151N621"/>
    <dbReference type="eggNOG" id="KOG3692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO32240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="945" mass="104741" checksum="FC35A23A6B9A6F8C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6N9</accession>
    <name>A0A151N6N9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="9">1.3.1.124</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2,4-dienoyl-CoA reductase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DECR2</name>
        <name evidence="15" type="ORF">Y1Q_0020364</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + NADPH + H(+) = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77559"/>
            <dbReference type="ChEBI" id="CHEBI:84791"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer, dimer and oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="9"/>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014452938.1">
        <property type="nucleotide sequence ID" value="XM_014597452.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6N9"/>
    <dbReference type="STRING" id="8496.A0A151N6N9"/>
    <dbReference type="GeneID" id="102565758"/>
    <dbReference type="CTD" id="26063"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000477">
        <property type="entry name" value="Peroxisomal 2,4-dienoyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO32407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="300" mass="31967" checksum="94032BD046121E9E" modified="2016-06-08" version="1">MAGVGAACCPPPDVDTDDCLPEYRPLLSPDVLRGRVALITGGGSGIGFRTAEIFMRHGCQTIIASRNLEKVTEAAKKLAAATGQRCLPLSLDVRQPQTIIAAVDEALKQFEQIDILINNAAGNFLCPASALSFNAYKTVIDIDTLGTFNVSKVLYEKCLRDHGGVIINITATLGYRGQALQVHAGTAKAAIDAMTRHLAVEWGPNNIRVNSLAPGPISGTEGYRRLGGKHCEASSRFNSIPLQRAGNKTEIAHSALYLASPLASYVTGMTMVVDGGSWLTLANDFPAMLDLWATEANKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N746</accession>
    <name>A0A151N746_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial</fullName>
            <ecNumber evidence="10">3.1.3.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pyruvate dehydrogenase phosphatase catalytic subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PDP2</name>
        <name evidence="17" type="ORF">Y1Q_0007817</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:12670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.43" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03003905">
        <property type="protein sequence ID" value="KYO32640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N746"/>
    <dbReference type="STRING" id="8496.A0A151N746"/>
    <dbReference type="eggNOG" id="KOG0700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000006">
        <property type="entry name" value="Pyruvate dehyrogenase phosphatase catalytic subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF343">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO32640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="409" mass="46694" checksum="8244CD7CE281D293" modified="2016-06-08" version="1">MTGAGSAGAGRDRVVSEFENDRKRRKTPKTLCFAERITSKSPSYDVKYLLEEMELATECMKPVLPILQWYKHPNDLMFREVASLYFDHLRVYWQDLLNLDLETGFSVEEALINAFKRLDSDITLEVQAPLENEVMRNIALQVAFSGATACVSHIDGVHLHVANAGDCRAILGVQEEDGTWSALSLTRDHNVFNEAEIRRLKEEHPKVEEKTIIVNDRLLGILIPSRSFGDVQLKWSKELQQSVLENGSNVEALNIYQYVPPNYYTPPYLTAEPEVTYHKLRRKDRFLVMASDGLWDMLNNEDVVKLVAEHLAESTVQKPELKKPVNLGYMQSLLLQRKSRSMGSLDQNIATHLIRHAVGNNEYGEVDQEKLVAMLTLPEDLARMYRDDITVTVVYFNSDAIENYYPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAR1</accession>
    <name>A0A151NAR1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAR1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7702" checksum="B6D90842DFD4F783" modified="2016-06-08" version="1">MDRGEELTSVNRTGVKKYLQKTNPNSDSSLYYWVRYPKCSENNGHSAHLTTRHKQTQVPVHLLADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAW6</accession>
    <name>A0A151NAW6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAW6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9655" checksum="14E9ECA2D4CDE8D2" modified="2016-06-08" version="1">MNVLPLQRTQLIGISSRERDLGTVTSRLPPWTHHSIRRLRNFIFSPSATRSQQATVIPAAHQATYDNIKEQPAIYKNTQMERGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ND23</accession>
    <name>A0A151ND23_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003364">
        <property type="protein sequence ID" value="KYO34640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ND23"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="133" mass="15282" checksum="01BCC297BDE8D807" modified="2016-06-08" version="1">MRIKISWINSHLAWVQHGSSCKDIEPMVNLHLLLYYRTSSISDYSLLTGQEELPLLDASRRRHYWIGYSRHGLLVMGEITFSTVNMSERNDPSDQSNARSKNGCQDQSKAKPREELCSHQRQAPRHLAPTCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDV0</accession>
    <name>A0A151NDV0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Down syndrome cell adhesion molecule isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DSCAM</name>
        <name evidence="20" type="ORF">Y1Q_0010966</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="15">Homodimer; mediates homophilic interactions to promote cell adhesion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003251">
        <property type="protein sequence ID" value="KYO34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NDV0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060219">
        <property type="term" value="P:camera-type eye photoreceptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd05734">
        <property type="entry name" value="Ig_DSCAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05735">
        <property type="entry name" value="Ig_DSCAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000729">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000141">
        <property type="entry name" value="Down syndrome cell adhesion molecule a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000176">
        <property type="entry name" value="Down syndrome cell adhesion molecule a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000215">
        <property type="entry name" value="Down syndrome cell adhesion molecule a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000167">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000172">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000219">
        <property type="entry name" value="Down syndrome cell adhesion molecule homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000229">
        <property type="entry name" value="Down syndrome cell adhesion molecule homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000120">
        <property type="entry name" value="Down syndrome cell adhesion molecule like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000264">
        <property type="entry name" value="Down syndrome cell adhesion molecule like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000315">
        <property type="entry name" value="Down syndrome cell adhesion molecule like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000477">
        <property type="entry name" value="DS cell adhesion molecule like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF53">
        <property type="entry name" value="DS CELL ADHESION MOLECULE LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1596"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="119"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="230"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="318"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="412"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="510"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="600"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="694"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="792"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="891"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="993"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1097"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1197"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="1282"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1387"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1482"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1720"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1784"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1844"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1736"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1784"/>
            <end position="1793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2103" mass="231698" checksum="CC68D3091CC93AC9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDY4</accession>
    <name>A0A151NDY4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Complexin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CPLX1</name>
        <name evidence="14" type="ORF">Y1Q_0000920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complexin/synaphin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDY4"/>
    <dbReference type="STRING" id="8496.A0A151NDY4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22808">
        <property type="entry name" value="Complexin_NTD_CPLX_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.580:FF:000001">
        <property type="entry name" value="Complexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.580">
        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF6">
        <property type="entry name" value="COMPLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="197" mass="22361" checksum="EC868AB805435463" modified="2016-06-08" version="1">MDFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQEEEERKAKYAKMEAEREVMRQGIRDKYGIKKKEEREAEAQAALEANAEGSLTRPKKAIPPGCGDEEEEEEESILDTVIKYLPGPLQDMFKKLYAEGVILSKNEVFIGSLLDTIGWDICLPDDVDWATLMLQKNQEDLWIKNVCALGLWRTPKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFE5</accession>
    <name>A0A151NFE5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translocon-associated protein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SSR1-2</name>
        <name evidence="3" type="ORF">Y1Q_0008080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFE5"/>
    <dbReference type="STRING" id="8496.A0A151NFE5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586013" evidence="2">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="108" mass="11641" checksum="6EEC517A05D23625" modified="2016-06-08" version="1">MRCWGSSATALAPVLGSQAGSSLLVAAQDATEDEEAVEDTVVEDEDDEAEVEEDEPTDLTEEKEEEDLSGEPKASPSADTTILFVKGEDFPANNIVKFLSRWVAVHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFT4</accession>
    <name>A0A151NFT4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">c-Myc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MYCBP</name>
        <name evidence="5" type="ORF">Y1Q_0013833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003146">
        <property type="protein sequence ID" value="KYO35624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006262549.1">
        <property type="nucleotide sequence ID" value="XM_006262487.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFT4"/>
    <dbReference type="STRING" id="8496.A0A151NFT4"/>
    <dbReference type="GeneID" id="102573089"/>
    <dbReference type="KEGG" id="amj:102573089"/>
    <dbReference type="CTD" id="26292"/>
    <dbReference type="eggNOG" id="ENOG502S2IC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="524165at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NFT4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21937">
        <property type="entry name" value="ZIP_MycBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO35624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="102" mass="11777" checksum="1C2518D18808C131" modified="2016-06-08" version="1">MAHYKAADSKREQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAAAPENPEIEALRLEVAEVKEKYEAVLEENKKLKAKLAQYEPPQEEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG06</accession>
    <name>A0A151NG06_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Placenta-expressed transcript 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG06"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reelin" evidence="1">
        <location>
            <begin position="89"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="269" mass="28783" checksum="1D917A88E69B78B6" modified="2016-06-08" version="1">MNADCEVLLGTDHAPARCFLPDAHLGSSLKTLSHPWELVHRETPGASAAREAAKLTMAALPFALQFVVLLGALVSPAYLQQCDQVTKNGTQRGFYTLTVYPTSYKANTSYTVTISNIKNSTAAYLQASIAPNSSVGRWEAQSCSNGHWVDQPRIAKESITAKWLSPDTTEGPVDIKVFVTFSNGSVLYQRQTLNYETGAVTGTRSTTYSAASGFTVTRTHSATHNAVTDSMVTKIHSTTDTAVSDSLASLSLVAAVQLLTLFATSNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHN1</accession>
    <name>A0A151NHN1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Interleukin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IL15-1</name>
        <name evidence="9" type="ORF">Y1Q_0020663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the IL-15/IL-21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003015">
        <property type="protein sequence ID" value="KYO36169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHN1"/>
    <dbReference type="STRING" id="8496.A0A151NHN1"/>
    <dbReference type="GeneID" id="102574944"/>
    <dbReference type="CTD" id="3600"/>
    <dbReference type="eggNOG" id="ENOG502SCMF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8905762at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042119">
        <property type="term" value="P:neutrophil activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050778">
        <property type="term" value="P:positive regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.70">
        <property type="entry name" value="Interleukin-15/Interleukin-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020439">
        <property type="entry name" value="IL-15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003443">
        <property type="entry name" value="IL-15/IL-21_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14356:SF3">
        <property type="entry name" value="INTERLEUKIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14356">
        <property type="entry name" value="INTERLEUKIN-15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02372">
        <property type="entry name" value="IL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01930">
        <property type="entry name" value="INTRLEUKIN15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO36169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="196" mass="22846" checksum="D1D45547CB1366A9" modified="2016-06-08" version="1">MRQPVYAGAGMWNFVGDSSRLENQRLPLRSICFQYLLHLLNNDFLSFLNYKTGLIIFILCCVNAYLPKTEAQSITPKLLRFFIDDLNEIKRLDCIDTSLYTASTSEYGGCEESVMNCFFSEMEVVRHESKIKQCTNNESVNTLLRNAKPYKLPLFQNASHVMKANCKQCEQYEERNFTEFVENFKILVQHLFKNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHT9</accession>
    <name>A0A151NHT9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0024135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NHT9"/>
    <dbReference type="eggNOG" id="ENOG502RP2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016064">
        <property type="term" value="P:immunoglobulin mediated immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003531">
        <property type="entry name" value="Hempt_rcpt_S_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048668">
        <property type="entry name" value="IL3RB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015321">
        <property type="entry name" value="TypeI_recpt_CBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037:SF22">
        <property type="entry name" value="CYTOKINE RECEPTOR COMMON SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21460">
        <property type="entry name" value="IL3Rb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09240">
        <property type="entry name" value="IL6Ra-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01355">
        <property type="entry name" value="HEMATOPO_REC_S_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="182"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="521"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="730"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="952"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1259"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1090"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1185"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1263"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO36382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1284" mass="145025" checksum="DB57095936A69115" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHV5</accession>
    <name>A0A151NHV5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA binding protein fox-1 homolog 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Fox-1 homolog B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RNA-binding motif protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RNA-binding protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RBFOX2</name>
        <name evidence="14" type="ORF">Y1Q_0024145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHV5"/>
    <dbReference type="STRING" id="8496.A0A151NHV5"/>
    <dbReference type="eggNOG" id="KOG0125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000375">
        <property type="entry name" value="RNA binding fox-1 homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025670">
        <property type="entry name" value="Fox-1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047131">
        <property type="entry name" value="RBFOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597">
        <property type="entry name" value="ATAXIN 2-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597:SF31">
        <property type="entry name" value="RNA BINDING PROTEIN FOX-1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12414">
        <property type="entry name" value="Fox-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO36396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="247" mass="25915" checksum="81A562CE93ED6B8D" modified="2016-06-08" version="1">MFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NI05</accession>
    <name>A0A151NI05_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 8 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GLT8D2</name>
        <name evidence="11" type="ORF">Y1Q_0024187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261692.1">
        <property type="nucleotide sequence ID" value="XM_006261630.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NI05"/>
    <dbReference type="STRING" id="8496.A0A151NI05"/>
    <dbReference type="GeneID" id="102566199"/>
    <dbReference type="KEGG" id="amj:102566199"/>
    <dbReference type="CTD" id="83468"/>
    <dbReference type="eggNOG" id="ENOG502QTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000078">
        <property type="entry name" value="glycosyltransferase 8 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO36446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="350" mass="40278" checksum="5BAC60024E79C631" modified="2016-06-08" version="1">MALLKKVNQILLVLLVLTVCVILYNKVHRVPSTLKNETAHLENGEEMEEEIPVVICAAAGRMGAVIAAINSIYSNTDANVLFYIVGLKNSIPHIRQWIENSKLREINFKIVEFNPMVLKGKIRHDASRPELLQPLNFVRFYLPLLIQKHEKVIYLDDDVIVQGDIQELYNTKLAPGHAAALSDDCDLPSTHEMVRSVGMQNTYMGFLDYRKQTVRDLGISPSTCSFNPGVFVANMTEWKHQRITKQLEKWMQKNVEENLYSSTLAGGVATSPMLIVFHEKYSAINPLWHIRHLGWSPDTRYSEHFLQDAKLLHWNGRYKPWDYPSVHTDLWEKWFIPDPSGKFKLIRPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIJ4</accession>
    <name>A0A151NIJ4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase domain-containing 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CECR5</name>
        <name evidence="4" type="ORF">Y1Q_0024312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIJ4"/>
    <dbReference type="STRING" id="8496.A0A151NIJ4"/>
    <dbReference type="GeneID" id="102576909"/>
    <dbReference type="KEGG" id="amj:102576909"/>
    <dbReference type="CTD" id="27440"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NIJ4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000081">
        <property type="entry name" value="Haloacid dehalogenase like hydrolase domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF17">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00069384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO36623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="449" mass="49895" checksum="892C5FE9459F9C78" modified="2016-06-08" version="1">MALCCLVTVSKAAWRKWLPEAQRSIVPARAEGLWASLWRSSSSSSSSSRGFAGRPLGITQTPTFGFLFDIDGVLVRGRHAIPAAREAFQKLTDSNGQLRVPVVFVTNAGNCFRHAKAQELSSALGLEVSPEQIILSHSPLLLFRQFHEKCVLVSGQGPIEENARNLGFQNVITIEALRKAYPLLDMVDQSRRPKELPPPTTDFPTIEGVILFGEPVRWETNLQLIIDVLLSNGNPGAELSAVPYPHIPVLACNMDLLWMAEAKMPRFGHGTFLLCLENIYRKVTGRELKYEALIGKPSIVTYHYAEYLIKQQAEKQGWESPICRLYAVGDNPMSDIYGANLYNSYLKAAHQTQAQAGVRGSMVAAGPQKDFNLGNDSNVLMESCESILVCTGVYRHHRDMPPVSNVCVRDTVFHGHRDFCFDPSLMEASYVVQDVNEAVKLAFEKETWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJ97</accession>
    <name>A0A151NJ97_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leucine-rich repeat-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Densin-180</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LRRC7</name>
        <name evidence="16" type="ORF">Y1Q_0020898</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with CNKSR2 and DLG4. Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2. Interacts with CAMK2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LAP (LRR and PDZ) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJ97"/>
    <dbReference type="STRING" id="8496.A0A151NJ97"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043194">
        <property type="term" value="C:axon initial segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06749">
        <property type="entry name" value="PDZ_densin_erbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000036">
        <property type="entry name" value="Erbin isoform 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000118">
        <property type="entry name" value="Leucine rich repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000061">
        <property type="entry name" value="leucine-rich repeat-containing protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF48">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="1161"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="578"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="653"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="884"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="956"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="994"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1040"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="956"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1045"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO36873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1272" mass="144024" checksum="70A05B26A8DAD2A0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJT1</accession>
    <name>A0A151NJT1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">WDR63</name>
        <name evidence="6" type="ORF">Y1Q_0020828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJT1"/>
    <dbReference type="STRING" id="8496.A0A151NJT1"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001352">
        <property type="entry name" value="WD repeat domain 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO36775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="867" mass="98716" checksum="B04E67907A3753D2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMP9</accession>
    <name>A0A151NMP9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Gamma-aminobutyric acid receptor subunit beta-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0007237</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMP9"/>
    <dbReference type="STRING" id="8496.A0A151NMP9"/>
    <dbReference type="KEGG" id="amj:102560663"/>
    <dbReference type="eggNOG" id="KOG3643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902711">
        <property type="term" value="C:GABA-A receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19053">
        <property type="entry name" value="LGIC_TM_GABAAR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000004">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000004">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022251779" description="Gamma-aminobutyric acid receptor subunit beta-4" evidence="18">
        <location>
            <begin position="28"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="37"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="249"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO38112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="56361" checksum="4BA2A81205FDAD8C" modified="2016-06-08" version="1">MWRFQADRLSGIVSAIAALCLACFAQSQSTGNISVVKEIVDKLLKGYDVRLRPDFGGNPVTVGMSIHISSIDQISEVNMDYTITMYFQQSWRDKRLAYNDLPLNLTLDNRVADQLWLPDTYFLNDKKSFLHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDQQNCTLEIESYGYTVDDIVFFWQGNDSAVTGMEMLELPQFTIIEQRLVTREVVFTTGSYLRLSLSFRIKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGVTTVLTMTTINTHLRETLPKIPYVKAIDVYLMGCFVFVFLALLEYAFVNYIFFGRGPRQQKKQSERINKANNERHRYEEKRVREQVDPYGNILLSTLEMNNELLATDMMSSVGDSRNSVMSFEGSGIQFRKQLASRDGFGHHLTLDRHVPLTHHAATRNRANCRLRRRSSKLKLKIPDLADVSTIDKWSRIIFPITFGFFNLIYWLYYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQK2</accession>
    <name>A0A151NQK2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0024458</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03002371">
        <property type="protein sequence ID" value="KYO39127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQK2"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020457">
        <property type="entry name" value="Znf_B-box_chordata"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01406">
        <property type="entry name" value="BBOXZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="15">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO39127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="156" mass="17331" checksum="AACBD89211913882" modified="2016-06-08" version="1">MAEEAVCSICLELLTEPVTIGCGHNFCRACITRYCEDAVRGSGNAIPCPSCRAEFQIGSFRLNTQLRNLVEKIKEQSLKPGKEKMATQCLEHEEKLKLFCEEDGEAICLICMQSQAHRGHTVLPIQEAANDYQVGDTTDLREPIAQTHTYLSGEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NS34</accession>
    <name>A0A151NS34_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase HECTD4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HECTD4</name>
        <name evidence="6" type="ORF">Y1Q_0018728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NS34"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13735">
        <property type="entry name" value="SPRY_HECT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000015">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HECTD4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000030">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HECTD4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043366">
        <property type="entry name" value="HECTD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035781">
        <property type="entry name" value="SPRY_HECTD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="4028"/>
            <end position="4387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1885"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2005"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2611"/>
            <end position="2637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3251"/>
            <end position="3305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3412"/>
            <end position="3442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3718"/>
            <end position="3794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2624"/>
            <end position="2637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3251"/>
            <end position="3278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="3279"/>
            <end position="3288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3412"/>
            <end position="3428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3432"/>
            <end position="3442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3718"/>
            <end position="3732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3761"/>
            <end position="3794"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="4355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO39681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="4387" mass="482285" checksum="1250250EAACFFA1F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSR8</accession>
    <name>A0A151NSR8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0006692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSR8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="121" mass="13899" checksum="C28BB9A7D453E4F7" modified="2016-06-08" version="1">MAIDFIGDAWNDVMQRCLNGVWKNIWPVVVNVSSKASEIKLISDARHEIVEMAKSVGFEQVSEENVAELLDSCREELLNKDLLELDRERHEEEEPMEENERPSPRILVMKGMADVFKLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NV64</accession>
    <name>A0A151NV64_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ankyrin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Erythrocyte ankyrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0014281</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1. Interacts with a number of integral membrane proteins and cytoskeletal proteins. Interacts (via N-terminus) with SPTB/spectrin (beta chain). Also interacts with TTN/titin. Isoform Mu17 interacts with OBSCN isoform 3/obscurin. Interacts with HIF1AN. Interacts (via ANK 1-5 repeats) with RHCE; this interaction mediates the primary membrane attachment site for ANK1. Interacts (via ANK 1-2 repeats) with AQP1 (via the N-terminal). Interacts (via ANK 1-13 repeats) with EPB42. Interacts directly with SLC4A1 (via the cytoplasmic domain); this interaction is mediated by the SLC4A1 Band 3-II and Band 3-III dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Sarcoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001890">
        <property type="protein sequence ID" value="KYO40678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NV64"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
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        <property type="entry name" value="ZU5_dom"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="UPA_2"/>
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        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ANKYRIN"/>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat"/>
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        <property type="match status" value="21"/>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="17">
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            <begin position="143"/>
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    <feature type="repeat" description="ANK" evidence="17">
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    <feature type="repeat" description="ANK" evidence="17">
        <location>
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    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
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    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="304"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="535"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="568"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="601"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="634"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="17">
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            <begin position="667"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="700"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="733"/>
            <end position="765"/>
        </location>
    </feature>
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        <location>
            <begin position="916"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="20">
        <location>
            <begin position="1073"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="19">
        <location>
            <begin position="1408"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="877"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1585"/>
            <end position="1625"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1647"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="877"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="893"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1647"/>
            <end position="1657"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004369"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO40678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1953" mass="213861" checksum="B43737799AB47E0B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW55</accession>
    <name>A0A151NW55_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Matrix metalloproteinase-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MMP24</name>
        <name evidence="24" type="ORF">Y1Q_0013712</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001786">
        <property type="protein sequence ID" value="KYO40963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="8496.A0A151NW55"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Matrix metallopeptidase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021805">
        <property type="entry name" value="Pept_M10A_metallopeptidase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF138">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11857">
        <property type="entry name" value="DUF3377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 24" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M10 metallopeptidase" evidence="22">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="19">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="19">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="19">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="19">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M10A matrix metallopeptidase C-terminal" evidence="23">
        <location>
            <begin position="310"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="18">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF11857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO40963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="379" mass="44236" checksum="8677B0A82A901DB9" modified="2016-06-08" version="1">MYVLSVGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETQNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSTSERKHERQPRPPRPPLGDRPSVPGMKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPTKIDAAYERSDGKFVFFKGDKYWVFKEVTAEPGYPHSLVELGISLPREGIDTALRWEPVGKTYFFKGDRYWRYNEDKRATDPGYPKPITVWRGIPQAPQGAFVSKEGFYTYFYKGKEYWKFDNQRLSVEPGYPRSILKDWMGCNQKEVERSKDRRLPHDDVDIMVTINDVPNTVNAIAVVIPCILSLCILVLVYTIFQFKNKEVQQNVTYYKRPVQEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW76</accession>
    <name>A0A151NW76_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Unconventional myosin-Ib</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MYO1B</name>
        <name evidence="16" type="ORF">Y1Q_0011877</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NW76"/>
    <dbReference type="STRING" id="8496.A0A151NW76"/>
    <dbReference type="GeneID" id="102561396"/>
    <dbReference type="KEGG" id="amj:102561396"/>
    <dbReference type="CTD" id="4542"/>
    <dbReference type="eggNOG" id="KOG0162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11827">
        <property type="entry name" value="SH3_MyoIe_If_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000010">
        <property type="entry name" value="Unconventional myosin-Ie"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035507">
        <property type="entry name" value="Ie/If_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF663">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="17"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="15">
        <location>
            <begin position="728"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="1041"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="914"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO41161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1098" mass="126364" checksum="C38ABACC9D1C89DE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYT3</accession>
    <name>A0A151NYT3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYT3"/>
    <dbReference type="STRING" id="8496.A0A151NYT3"/>
    <dbReference type="KEGG" id="amj:102562585"/>
    <dbReference type="eggNOG" id="ENOG502S4TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031946at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NYT3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020339">
        <property type="entry name" value="C20orf85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31909">
        <property type="entry name" value="CHROMOSOME 20 ORF85 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31909:SF3">
        <property type="entry name" value="SIMILAR TO PROTEIN C20ORF85 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14945">
        <property type="entry name" value="LLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO42041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="132" mass="15021" checksum="E3A49B6E4634B3AD" modified="2016-06-08" version="1">MAQIGSSPTQQLSLVEQDQIWKSCVHKELEAARKWANKWGFLATSPEELIKKEKKEPSKPKIELPEHLQIRPLTPLEKYIKANPSPPVPKTTQGFIGWRSSVPGLKLEHGYQIRSCKGAFHKDLRWPDGPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZ22</accession>
    <name>A0A151NZ22_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Eyes absent homolog</fullName>
            <ecNumber evidence="15">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0002767</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZ22"/>
    <dbReference type="STRING" id="8496.A0A151NZ22"/>
    <dbReference type="KEGG" id="amj:106736722"/>
    <dbReference type="eggNOG" id="KOG3107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167668at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NZ22"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02601">
        <property type="entry name" value="HAD_Eya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12350:FF:000001">
        <property type="entry name" value="Eyes absent homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006545">
        <property type="entry name" value="EYA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042577">
        <property type="entry name" value="EYA_dom_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01658">
        <property type="entry name" value="EYA-cons_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF7">
        <property type="entry name" value="EYES ABSENT HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 15" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO42136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="534" mass="59009" checksum="3B06B0AEAA0B1EF0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0Q9</accession>
    <name>A0A151P0Q9_ALLMI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001358">
        <property type="protein sequence ID" value="KYO42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0Q9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="8670" checksum="3AC49FF33818DF0A" modified="2016-06-08" version="1">MEKSEVEKLIESHTEELTDVDLAELMTNSDNEDDENENEETERPNFNLGTLAELFRYSKELTDKMFEYDPFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1E9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
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                <person name="Pourmand N."/>
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                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
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                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001328">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="8967" checksum="05AE317AD31BAED7" modified="2016-06-08" version="1">MDQRITNWLNISKKLQALEIFELLSQQKQGGVTMKPAVDRKSKALPNAEEDRDILQEGQDDHENGNDSNGLKRTMQTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P217</accession>
    <name>A0A151P217_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010279</name>
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    <organism evidence="1 2">
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        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
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                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001300">
        <property type="protein sequence ID" value="KYO42949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P217"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO42949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7561" checksum="C85B773780AEE39F" modified="2016-06-08" version="1">MENPDLATYADMQAPAIGPVDMLGQNLQLLTQILGYQQQILDQQQEWRQHSLASFKMPKMTKEDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2M2</accession>
    <name>A0A151P2M2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR and ankyrin repeat-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TRANK1</name>
        <name evidence="8" type="ORF">Y1Q_0017571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P2M2"/>
    <dbReference type="eggNOG" id="ENOG502QQZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1371"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2946"/>
            <end position="2973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO43273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2977" mass="341467" checksum="DA0D850AE867F57C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5F7</accession>
    <name>A0A151P5F7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PSMB3</name>
        <name evidence="5" type="ORF">Y1Q_0012067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5F7"/>
    <dbReference type="STRING" id="8496.A0A151P5F7"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151P5F7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO44288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="205" mass="22983" checksum="33E104F272F5FC74" modified="2016-06-08" version="1">MSIMSYNGGAVMAMKGKNCVAVAADKRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPQTFMSMVSNLLYERRFGPYYTEPVIAGLDPITYEPFICSLDLIGCPMITDDFVVSGTCSEQMYGMCESLWEPDMEPDHLFETISQAMLNAVDRDAVSGMGVVVHIIEKDKITTRTLKARMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P632</accession>
    <name>A0A151P632_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000760">
        <property type="protein sequence ID" value="KYO44504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P632"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="115" mass="13008" checksum="00F576AEA86E0774" modified="2016-06-08" version="1">MGESNKNVTCSVRNLHWNQEKTATIHIEGFVPGCLTSGFWLLQDFPEPNNIQRNIEILRVGLTPQDNTRRGPGTILETVAVGRDWVGNPCPRRQKVPRDSRQKGFCEAHLLTSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6C7</accession>
    <name>A0A151P6C7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000701">
        <property type="protein sequence ID" value="KYO44627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6C7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="82" mass="8969" checksum="757465944A71E1A0" modified="2016-06-08" version="1">MGDFPGNPSPFLLGPIAKSCESKTLPARLSSWAEPQIALKSLPLTFRDAFEVFINALNAHLPFKAEPWIAMKSPPLTCSYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P752</accession>
    <name>A0A151P752_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P752"/>
    <dbReference type="STRING" id="8496.A0A151P752"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="129" mass="15182" checksum="D06E5C0B4C8C19AB" modified="2016-06-08" version="1">MERGLVTLLYKKGLREELKNWRLITLLNFDSKLLAKVLAERFKSILGALIHKDQPCGMLGCQIHRALVQLRDALQLERERRQSVAVLNLDLEKTYDRTSHQFLFQTLEQMGVPPDFRWLDQDPLHRSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8Q3</accession>
    <name>A0A151P8Q3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FAM181A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM181A</name>
        <name evidence="2" type="ORF">Y1Q_0015137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006278984.1">
        <property type="nucleotide sequence ID" value="XM_006278922.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8Q3"/>
    <dbReference type="STRING" id="8496.A0A151P8Q3"/>
    <dbReference type="GeneID" id="102576812"/>
    <dbReference type="KEGG" id="amj:102576812"/>
    <dbReference type="CTD" id="90050"/>
    <dbReference type="eggNOG" id="ENOG502RZWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5982901at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029359">
        <property type="entry name" value="FAM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053819">
        <property type="entry name" value="TEADIR3_omega_loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33766:SF1">
        <property type="entry name" value="PROTEIN FAM181A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33766">
        <property type="entry name" value="PROTEIN FAM181B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15238">
        <property type="entry name" value="TEADIR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="291" mass="32181" checksum="A68228D61B682B22" modified="2016-06-08" version="1">MASDSEVKMLLNFVNLASSDIKAALDKSAPCRRSVDHRKYLQKQLKRFSQKYSRIPRSHPSKSMESNMKRGVEDRNRSSHPDALDPNPCRATSEKALRGAEVEENLSGEQGLQEQSPESARPDQVPMRKRQLPASFWEEPRPAQSLMVGSFPAGLDGLPKSRDLPSYEGKKSKKSPDATGPESPPVPVQPSGEKEPIKVPGTSLSGRMNAWSCCPFQYHGQPVYQTPGALPQSPFPGLGLWRKNTAPQGEIQHFCKETDATGQKLYRPVVLKPIPTKPAVPPPIFNVFGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9K1</accession>
    <name>A0A151P9K1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0021352</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9K1"/>
    <dbReference type="STRING" id="8496.A0A151P9K1"/>
    <dbReference type="KEGG" id="amj:102572009"/>
    <dbReference type="eggNOG" id="KOG0986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P9K1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08750">
        <property type="entry name" value="RGS_GRK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000009">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000074">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF14">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="13">
        <location>
            <begin position="56"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="183"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="446"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO45674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="572" mass="66142" checksum="6D235F149E7A2EE3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAV4</accession>
    <name>A0A151PAV4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAV4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7833" checksum="4E2AF918B458232F" modified="2016-06-08" version="1">MAGQAEMDPGLYEKEEGTENIEGRSSTNARDLNLSPTSQKHIELQGYIQMNRNVWYVAAQSSVAPHTLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE19</accession>
    <name>A0A151PE19_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Platelet endothelial aggregation receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PEAR1</name>
        <name evidence="20" type="ORF">Y1Q_0012436</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MEGF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000456">
        <property type="protein sequence ID" value="KYO47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PE19"/>
    <dbReference type="STRING" id="8496.A0A151PE19"/>
    <dbReference type="eggNOG" id="KOG1218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000007">
        <property type="entry name" value="multiple epidermal growth factor-like domains protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000114">
        <property type="entry name" value="Multiple epidermal growth factor-like domains protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000021">
        <property type="entry name" value="Platelet endothelial aggregation receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057138">
        <property type="entry name" value="EGF_PEAR1L-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052485">
        <property type="entry name" value="MEGF_diff_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24052">
        <property type="entry name" value="DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24052:SF12">
        <property type="entry name" value="PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23301">
        <property type="entry name" value="EGF_PEAR1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586941" evidence="16">
        <location>
            <begin position="21"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="19">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="406"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="661"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="781"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="895"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="960" mass="102134" checksum="E7736F7F2E9EBC73" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE91</accession>
    <name>A0A151PE91_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox protein Nkx-2.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0013171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="amj:109285041"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF40">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-2.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
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    <feature type="DNA-binding region" description="Homeobox" evidence="5">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <begin position="181"/>
            <end position="191"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="204"/>
            <end position="214"/>
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    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO47343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="214" mass="23225" checksum="83EB885CC8CFCFCA" modified="2016-06-08" version="1">MEAPGMEDFGQFVPAGPQPCLGPPGFPVPHCLSPGSMQGYRSGGFASPGDLPGYHQDGYHGPDWYRTVQEGPYPAISRYVGPAGFGAPGPGCLSYLGEMAKPPGLVLAPGGRRKRRVLFSQAQVCELEKRFERQKYLTAVERERLAQLTCLTPTQVKIWFQNHRYKAKRQAKRRDVGDGPPAEPPPEPRPALKPCCLLSGLAPGSQNSPGGKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEZ8</accession>
    <name>A0A151PEZ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase C-binding protein NELL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NELL2</name>
        <name evidence="12" type="ORF">Y1Q_0019753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014456567.1">
        <property type="nucleotide sequence ID" value="XM_014601081.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEZ8"/>
    <dbReference type="STRING" id="8496.A0A151PEZ8"/>
    <dbReference type="GeneID" id="102560955"/>
    <dbReference type="KEGG" id="amj:102560955"/>
    <dbReference type="CTD" id="4753"/>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6516201at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000121">
        <property type="entry name" value="Neural EGFL like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000120">
        <property type="entry name" value="Protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000211">
        <property type="entry name" value="Protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000015">
        <property type="entry name" value="protein kinase C-binding protein NELL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000102">
        <property type="entry name" value="Protein kinase C-binding protein NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000111">
        <property type="entry name" value="Protein kinase C-binding protein NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000023">
        <property type="entry name" value="protein kinase C-binding protein NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051586">
        <property type="entry name" value="PKC-binding_NELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042">
        <property type="entry name" value="NEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24042:SF0">
        <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN NELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586973" evidence="9">
        <location>
            <begin position="22"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="11">
        <location>
            <begin position="271"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="396"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="481"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="554"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="601"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="11">
        <location>
            <begin position="697"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO47666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="815" mass="91055" checksum="C98F3CD92610781C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PF56</accession>
    <name>A0A151PF56_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PF56"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10755" checksum="0AF9D68779305224" modified="2016-06-08" version="1">MWYLIIGTRLRETQDPTEFSGEAGYVKLAICKTLGLDDISPLAFGKYHQRSSIFQHHSPGGLFQLLFPKASTLTQHRSPGLVLQRWWRQAAAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFZ4</accession>
    <name>A0A151PFZ4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRPL4</name>
        <name evidence="9" type="ORF">Y1Q_0020741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000333">
        <property type="protein sequence ID" value="KYO47912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFZ4"/>
    <dbReference type="STRING" id="8496.A0A151PFZ4"/>
    <dbReference type="eggNOG" id="KOG1624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_uL4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO47912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="300" mass="33375" checksum="FE2C29DF0B507A21" modified="2016-06-08" version="1">MTWQGSAHLEPCTEQALSMSSGQTGPLGTSTTPASLVNVAAQAEKPPPVILETPILRECPIAIPAHRTPVQAWVESLRHYDDQPVGLADLHPDVFAVMPRVDILHTVAIWQKNFKRISYAKVKTRAEVRGGGKKPWKQKGSGRARHGSIRSPLWRGGGVVHGPRGPTSYYYMLPMKVRVSGLKVALTTKLMQDNLHIVDNLELPTPDSQYLANLAQYRRWGQSVLIVDVNEMPENITRAVAGLKSITLVPGLGLNVHSMLKHETLVLTLDTVAFLEEKLLWHDVRYTALYPFRLPYCDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PG82</accession>
    <name>A0A151PG82_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HPDL</name>
        <name evidence="11" type="ORF">Y1Q_0003593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16189"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="EC" id="1.13.11.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16190"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000266">
        <property type="protein sequence ID" value="KYO47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019345028.1">
        <property type="nucleotide sequence ID" value="XM_019489483.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019345034.1">
        <property type="nucleotide sequence ID" value="XM_019489489.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019345044.1">
        <property type="nucleotide sequence ID" value="XM_019489499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PG82"/>
    <dbReference type="STRING" id="8496.A0A151PG82"/>
    <dbReference type="GeneID" id="109283632"/>
    <dbReference type="KEGG" id="amj:109283632"/>
    <dbReference type="CTD" id="84842"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF10">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="179"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="396" mass="42940" checksum="86E13EEFFD05B05B" modified="2016-06-08" version="1">MAASVSRLCHVAFHVPRGQGLASDLVTKFRFRPVAVRETARARQLAVCKGAAVFVVNERREAAPCSGPTWPSPGPGASDFLYDVDPAYAVSTACNVCFELEDIPGVSRRLQDRGCRLAVPPTEVTDADGSVTYSVVRSIVGNVSHTLLDRSRYRGPFLPGFHAVTAAPEGPPDGAEITHVDHITYACPRGSARTVLDWYESCFGFRRFLLHGAEDAGEGYVIRGRGVGLRLMALQGGRAERARPTDGCKLVLAESLPEQGQNQVDTFLEQHGGAGVQHIGLYTTDIVSTAQTLAAAGVQFVEPPRTYYSEAGKTEEIQGAGQDPGALARHGILLDAELAGESPSARRYLMQIFTKPFFPEETFFLELIERRGASGFGEGNIRALWKSVQGYMDRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIA3</accession>
    <name>A0A151PIA3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIA3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="10833" checksum="BF6466CA587D7852" modified="2016-06-08" version="1">MHRTQESPFPTKCSHHCTTCTMERVEQRVDRGRDKQILIPGLSVRCHGIQSLKVAISDNGKNKSIVLVHLKSQHKTTTFRLMVMAGNPVKIIVVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZN7</accession>
    <name>A0A151LZN7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium channel subfamily K member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KCNK3</name>
        <name evidence="17" type="ORF">Y1Q_0005877</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006868">
        <property type="protein sequence ID" value="KYO17700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014458434.1">
        <property type="nucleotide sequence ID" value="XM_014602948.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZN7"/>
    <dbReference type="STRING" id="8496.A0A151LZN7"/>
    <dbReference type="GeneID" id="102574861"/>
    <dbReference type="KEGG" id="amj:102574861"/>
    <dbReference type="CTD" id="3777"/>
    <dbReference type="eggNOG" id="KOG4404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005252">
        <property type="term" value="F:open rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000057">
        <property type="entry name" value="Potassium channel subfamily K member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005406">
        <property type="entry name" value="KCNK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF138">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01584">
        <property type="entry name" value="TASK1CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="167"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO17700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="387" mass="43111" checksum="9082EDED4DF5666B" modified="2016-06-08" version="1">MKRQNVRTLALIGCTFTYLLVGAAVFDALESEQETEEKRRLEQKRLELASKYNLSTAGYRELEWVVLKLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVKYLLHRMKKCLGMRRAEVSMANMVTIGFFSCISTLCIGAAAFSYYEHWSFFHAYYYCFITLTTIGFGDYVALQKDGALQTKPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQASSVHTTDTASSTPAAGGGGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSRASPGRYPDTASNRCFCNAQRSAISSVSTGLHSLAAFPGLMKRRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M124</accession>
    <name>A0A151M124_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M124"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="8540" checksum="09A51A4CB7D0B3F3" modified="2016-06-08" version="1">MGGSACMDPIAKSRPKIGYSMHYKSSHSHCVNWPGRADCTELLLLLPACLTRALSNTATRGQATLLSTLFSQVSDTQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M180</accession>
    <name>A0A151M180_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(P)(+)--arginine ADP-ribosyltransferase</fullName>
            <ecNumber evidence="10">2.4.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mono(ADP-ribosyl)transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0012769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19149"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:15087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142554"/>
            <dbReference type="EC" id="2.4.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Arg-specific ADP-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.31" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03006834">
        <property type="protein sequence ID" value="KYO18277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M180"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044194">
        <property type="term" value="C:cytolytic granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106274">
        <property type="term" value="F:NAD+-protein-arginine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.176.10:FF:000001">
        <property type="entry name" value="NAD(P)(+)--arginine ADP-ribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.176.10">
        <property type="entry name" value="Toxin ADP-ribosyltransferase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050999">
        <property type="entry name" value="ADP-ribosyltransferase_ARG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000768">
        <property type="entry name" value="ART"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339">
        <property type="entry name" value="ADP-RIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10339:SF2">
        <property type="entry name" value="ECTO-ADP-RIBOSYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01129">
        <property type="entry name" value="ART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00970">
        <property type="entry name" value="RIBTRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01291">
        <property type="entry name" value="ART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51996">
        <property type="entry name" value="TR_MART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO18277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="386" mass="43571" checksum="1D2AF77368FFCE92" modified="2016-06-08" version="1">MGFHLGASRHSQSLTVIQGSNCDHLEPKILLLPWFKHRSTFSDSFGHRSPEREASPLLSTENPHLAADMTWPRGIFLLCCFWPSDLAQQPPARQTVMMSMMPDAFDDQYIGCAKEMETEAPALMKNELEKSTLLKRAWKNSSIHWEEVREYLYTDLPKGFKEEHGRAIIAYTDNFLRRQLNKAVQESGASSDAYHTHFHFKAFHYYLTRALQLLRMDCNLMYEIPVYRGVHHIRYQHNGCAPIRFGYFASSSFEIKKAEEFGKDTFFTIHTCFGVPILYFSYILNENEALIPVNEIFSVFPGDSGDNSFVLRSTNRTCSYFNCAFLGFLVALTGGCQSGPSPTSACQAYGLSTGCGSWTYVFSSFGAVVNSCTPSVRSLDISGDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1F7</accession>
    <name>A0A151M1F7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0012802</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006834">
        <property type="protein sequence ID" value="KYO18322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1F7"/>
    <dbReference type="eggNOG" id="ENOG502RF9W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15222">
        <property type="entry name" value="7tmA_OR51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000002">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF104">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO18322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="258" mass="29236" checksum="C57C86FFD530CBE2" modified="2016-06-08" version="1">MYFFLSMLAVTDLGLSASTLPTMLSIFTFNVREVHIDACIAQLYFIHTFSLMESAVLLAMAFDRFVAIHQPLRYNSILTHATVARIGLGFAVRSVLMVMPTPILLRRLQFCFPNILSHSFCLHQDVMKLSCSDRRINSIYGLFVVISTMGLDSMLIVLSYVMIIKTVLSIASKEERLKALNTCVSHICAVLTFYIPMIGISMIHRFGKHASPLIHVFMAIVYVLVPPVMNPVVYSVKTKQIRQRIIQKLQRQNTMDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2Q1</accession>
    <name>A0A151M2Q1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2Q1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="6989" checksum="789E4BE3142CE5B3" modified="2016-06-08" version="1">MAAASGELLQAATAVSGGRGDKCQPVVGDHPQMLLAALVVASSDWGLPIDAVDTVKKIRIRDRSSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3G1</accession>
    <name>A0A151M3G1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3G1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="102" mass="11850" checksum="23E8CCF500F71FF5" modified="2016-06-08" version="1">MPLHWVLHTPAKAHQHQDWYVEAQQAIEEATLVSSSTPHTTSEGHNWYQEETTDLIVLWGEAEVLIQVLMQDLQLYTGERYQLASGIRRQLLLQDLMELRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M697</accession>
    <name>A0A151M697_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M697"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="130" mass="15192" checksum="2F0F0959D105424C" modified="2016-06-08" version="1">MNRVLENVAFISYQLVSYTRNHIELNTRHSKLNQRGEETATVHSTASGWLNEMMLYTQLHLRREKKLPKNGKEEIYHIICLSTAFPLGLWRFPNGSRFPLTRATGQCGHLTNRLLWDQQQGLLADLHFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB90</accession>
    <name>A0A151MB90_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptotagmin-13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Synaptotagmin XIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SYT13</name>
        <name evidence="12" type="ORF">Y1Q_0000487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in transport vesicle docking to the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with NRXN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019332677.1">
        <property type="nucleotide sequence ID" value="XM_019477132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MB90"/>
    <dbReference type="STRING" id="8496.A0A151MB90"/>
    <dbReference type="GeneID" id="102576953"/>
    <dbReference type="KEGG" id="amj:102576953"/>
    <dbReference type="CTD" id="57586"/>
    <dbReference type="eggNOG" id="KOG1028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9997431at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MB90"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000101">
        <property type="entry name" value="Synaptotagmin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000145">
        <property type="entry name" value="Synaptotagmin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF250">
        <property type="entry name" value="SYNAPTOTAGMIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="159"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="292"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO21796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="431" mass="48200" checksum="460307A374D0B37E" modified="2016-06-08" version="1">MVLSAPVIALGATLGTATSILALCGLTCFCKSRQPRKGLSGKDQDEDLENAKPSVLQPVQQFNIKKTAEPVQPRTLLKFPNIYGPKPVVTSPEVVNYTDYALKTTEEPTKGKHTVLDENRMKIQVNEELFVLPQNVPGVVKDVCVTERLNPERAASCNQVPELQYSLGYDRQKAELCVAFLEAMHGSMIGDQDPGSHCYILGTVVTKSGITEAQTELKKKALHTIWEEALLFPVAEEEMPEGTLTLTLRTCDKFSRHSIVGELKLSLAEVGEPFGTAQWEKLKTLEKVPSTGYGEVLLSISYLPAANRLLVVIIKAKNLHSKQLKVLLGNDVFVKVTLKHQSVKLKKKQTKHAKHKINPVWNEMIMFEVPHELLRASTVELEMMTQESRGQNQSLGKCSLGLHATSTEKNHWEEMLRNPRRQIAMWHQLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBE1</accession>
    <name>A0A151MBE1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 20">V(D)J recombination-activating protein 1</fullName>
            <ecNumber evidence="3 20">2.3.2.27</ecNumber>
            <ecNumber evidence="20">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">RAG1</name>
        <name evidence="24" type="ORF">Y1Q_0000519</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="20">Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="18">The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18 20">Belongs to the RAG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3 20"/>
    <dbReference type="EC" id="3.1.-.-" evidence="20"/>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBE1"/>
    <dbReference type="STRING" id="8496.A0A151MBE1"/>
    <dbReference type="eggNOG" id="ENOG502QSFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097519">
        <property type="term" value="C:DNA recombinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905347">
        <property type="term" value="C:endodeoxyribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990238">
        <property type="term" value="F:double-stranded DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033077">
        <property type="term" value="P:T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033151">
        <property type="term" value="P:V(D)J recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16530">
        <property type="entry name" value="RING-HC_RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000142">
        <property type="entry name" value="Recombination activating gene 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024627">
        <property type="entry name" value="RAG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058557">
        <property type="entry name" value="RAG1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058552">
        <property type="entry name" value="RAG1_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035714">
        <property type="entry name" value="RAG1_imp-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058553">
        <property type="entry name" value="RAG1_pre-RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058554">
        <property type="entry name" value="RAG1_RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058555">
        <property type="entry name" value="RAG1_ZnC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019485">
        <property type="entry name" value="RAG1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058556">
        <property type="entry name" value="RAG1_ZnH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023336">
        <property type="entry name" value="RAG_nonamer-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058558">
        <property type="entry name" value="RING-HC_RAG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11539:SF0">
        <property type="entry name" value="V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11539">
        <property type="entry name" value="VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12940">
        <property type="entry name" value="RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26105">
        <property type="entry name" value="RAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26024">
        <property type="entry name" value="RAG1_DNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12560">
        <property type="entry name" value="RAG1_imp_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26025">
        <property type="entry name" value="RAG1_pre-RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26100">
        <property type="entry name" value="RAG1_RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26101">
        <property type="entry name" value="RAG1_ZnC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26104">
        <property type="entry name" value="RAG1_ZnH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10426">
        <property type="entry name" value="zf-RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51487">
        <property type="entry name" value="NBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51765">
        <property type="entry name" value="ZF_RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="15 18 20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14 18 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 20" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 20" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16 18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="RAG1-type" evidence="23">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="NBD" evidence="22">
        <location>
            <begin position="385"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NBD" evidence="18">
        <location>
            <begin position="385"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU366024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO21835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1036" mass="118835" checksum="B4E48007204A0412" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBI7</accession>
    <name>A0A151MBI7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBI7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="102" mass="12257" checksum="CA5C422B0AD14495" modified="2016-06-08" version="1">MKATFIFIDTYQIKCIISQRKMWSCQLNSKAYKAIWKKAQWHNKDVTQNRNMMRNTSLIWGIPKRVQLGLFIPTQLNKTEEDQLLCTKNEAKMFKFILKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBJ0</accession>
    <name>A0A151MBJ0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor E2F8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">E2F8-1</name>
        <name evidence="14" type="ORF">Y1Q_0000564</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBJ0"/>
    <dbReference type="STRING" id="8496.A0A151MBJ0"/>
    <dbReference type="eggNOG" id="KOG2578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002040">
        <property type="term" value="P:sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000073">
        <property type="entry name" value="E2F transcription factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000100">
        <property type="entry name" value="E2F transcription factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF40">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="13">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="13">
        <location>
            <begin position="265"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO21896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="882" mass="98106" checksum="4FCA6C5D944B4055" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGG5</accession>
    <name>A0A151MGG5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat and SOCS box protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ASB3</name>
        <name evidence="7" type="ORF">Y1Q_0002229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGG5"/>
    <dbReference type="STRING" id="8496.A0A151MGG5"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03722">
        <property type="entry name" value="SOCS_ASB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037329">
        <property type="entry name" value="ASB3_SOCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO23583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="419" mass="47355" checksum="97C94F23DD60BE81" modified="2016-06-08" version="1">MAVENGHSEAVKLLLRYGANINGPHSWSGWNSLHQASFQGYTEIIKLLLEKGANKECEDDFGITPLFIAAQYGKLESLRVLISHGANVNCQAKDKATPLFIAAQEGHTECVELLLSKGADPNLYCNEEEWQLPIHAAAQMGHSNILGLLIPVTGRICDMGKDKVSPVYSAVYGGNDKCLEMLLKEGYSPDAQMCLIFDCRSPMCMVFQKEIHLLGINLGYCLHHEKFSLFRHFLKLDCPLPSEEHLPEFINYAIKTQEQYKEWLPYLLLSGFSPLNLLCRLWIYSLNNNALNFTLEFTNWKRLPSAVEQNLSDYKENSTWVPHSHFAFIPSLSHLCRLEIRSLLQSKHLRSDKFIRMLPLPTCLQDYLLCFDILRMNAIPEAVDAQGEMAEGMLYSAHSSAGDAERKQGNNRARCSHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGP1</accession>
    <name>A0A151MGP1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0002294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGP1"/>
    <dbReference type="STRING" id="8496.A0A151MGP1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="74"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO23663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="174" mass="19716" checksum="C0CB51470DEF9404" modified="2016-06-08" version="1">MSEGDQMEIADEIHEKDDMENPDKMSEETEMGEDKMELSLLLLVLDLLDSIEAQIGIAMYAMMILVNSCNEMPAGWDGFAHDALVFRNFPLPGLMEKGYYAPGVPNRVICGVAIPPFTIADVAYPLKPWLMKPYGGHVIDLQKMVFNYHLSKCRMAVEYAFGYLRVQWRVLNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIB3</accession>
    <name>A0A151MIB3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoprotein TPR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Megator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">NPC-associated intranuclear protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Translocated promoter region protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">TPR</name>
        <name evidence="35" type="ORF">Y1Q_0004263</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Centromere</location>
            <location evidence="5">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MIB3"/>
    <dbReference type="eggNOG" id="KOG4674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090316">
        <property type="term" value="P:positive regulation of intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046824">
        <property type="term" value="P:positive regulation of nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1490:FF:000004">
        <property type="entry name" value="nucleoprotein TPR isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1490:FF:000005">
        <property type="entry name" value="nucleoprotein TPR isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="25" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0132">Cell division</keyword>
    <keyword evidence="26" id="KW-0137">Centromere</keyword>
    <keyword evidence="9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="20 30" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="23" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="21" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="33">
        <location>
            <begin position="172"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="34">
        <location>
            <begin position="472"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="32">
        <location>
            <begin position="1042"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1459"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1624"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1730"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="2191"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="30">
        <location>
            <begin position="54"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="30">
        <location>
            <begin position="427"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="30">
        <location>
            <begin position="543"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="30">
        <location>
            <begin position="667"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="30">
        <location>
            <begin position="997"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="30">
        <location>
            <begin position="1224"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="30">
        <location>
            <begin position="1481"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="918"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="1460"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="1624"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="1638"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="1747"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="1770"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="1806"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="31">
        <location>
            <begin position="1872"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="1887"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="1930"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="31">
        <location>
            <begin position="1952"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="1989"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="2191"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="2206"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="31">
        <location>
            <begin position="2220"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="31">
        <location>
            <begin position="2246"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="2261"/>
            <end position="2278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00077074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00079318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00083105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KYO24213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2325" mass="262569" checksum="78700CCDA4C5D209" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLX5</accession>
    <name>A0A151MLX5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0023960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005753">
        <property type="protein sequence ID" value="KYO25524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLX5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000212">
        <property type="entry name" value="zinc finger protein 382 isoform X2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="13">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO25524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="421" mass="48156" checksum="977D7D976FB2DB80" modified="2016-06-08" version="1">MTFEEVAVYFTTEEWALLDPSQRALYSAVMQENYETVASLGFPIPRLDVVSQMEEGEEPWVLDLQYSTESEMLRSILMVGEGVVDKNEEAMLQEEGPEQAEPCGKSSVQSKGNASLNLCTDFKQGNPLVDTCGISPCCGDDSEDFKDILIPPRLHAREDKYKCTECGRGFTRSSDLLVHQRTHTGERPFVCPDCGQSFSHRSNFLRHQRSHVGEKPFTCPDCRKSFMGTSDLLIHQRTHTGERPYTCPECGRSFSHRSNFLRHQRSHTGEKPFLCPDCGKSFMGTSDIKRHQRTHTGEKPYSCPECGQSFSRSSNFIRHKRTHTGEKPFLCPDCGKSFRERSDFYRHHRIHMGDRPYPCLDCGKSFAVNSDLARHKRVHMGEKPYQCQECGKSFRRSCHLIAHQRAYLTLTSTKGREKHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNP9</accession>
    <name>A0A151MNP9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNP9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="12464" checksum="7F489F794715D8C2" modified="2016-06-08" version="1">MEKYQLRNFPCQPWESGQQAEQELLLPASFPCVFELHQGRFSLLWVHPIIPDRDSLHSLHRGYPSTGNSSRACGTCYKRIGGLPFLLCWTIAFEVQSGKNYLSSSFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MP63</accession>
    <name>A0A151MP63_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005569">
        <property type="protein sequence ID" value="KYO26314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MP63"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="86" mass="9142" checksum="F2EBEB43502F3A6E" modified="2016-06-08" version="1">MAETGLRAGNPEPCLEGQGEGEGQDLRLSVSRGSRLISALLFAPEACELAPLLPWLLHESVSCSQLFLESPVPGTSAQPVDRDRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPQ7</accession>
    <name>A0A151MPQ7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPQ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="83" mass="9015" checksum="ED183290BFB49D53" modified="2016-06-08" version="1">MSDDGKKETCEHCPGGLDKKCRVFLEAVGASYHWYGNICTSNRTGGPASIAIAAEHPYWRLSHHAAGGGKQKSTPSMNTENFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQ68</accession>
    <name>A0A151MQ68_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytoplasmic dynein 1 intermediate chain 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cytoplasmic dynein intermediate chain 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Dynein intermediate chain 1, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0019161</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQ68"/>
    <dbReference type="STRING" id="8496.A0A151MQ68"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000108">
        <property type="entry name" value="cytoplasmic dynein 1 intermediate chain 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000026">
        <property type="entry name" value="cytoplasmic dynein 1 intermediate chain 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF34">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO26686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="675" mass="75754" checksum="689580B199AFBC51" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQ79</accession>
    <name>A0A151MQ79_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQ79"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="12042" checksum="51562F47CC9EDC1A" modified="2016-06-08" version="1">MPGTSIKSQNQHSEKGGCNHTIAPPLDLLCHIPGLTNWEGLQLRKKTQPNIFDDAGKKKDTAMHIITLMKDNNEIMLSSKCSSLMAASFKINGHPASRIRYSINSPIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQX3</accession>
    <name>A0A151MQX3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQX3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="8587" checksum="1FD2CDF0D0838A09" modified="2016-06-08" version="1">MVTASTTRTVAGGVELRLEESSCKLTWEMSIINSSGPSQLLSSSSHLAASSLPKKRQVILPSNTIKKTAIQERRVTRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR73</accession>
    <name>A0A151MR73_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasmolipin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Plasma membrane proteolipid</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PLLP</name>
        <name evidence="14" type="ORF">Y1Q_0018200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Myelin membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005442">
        <property type="protein sequence ID" value="KYO27038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR73"/>
    <dbReference type="STRING" id="8496.A0A151MR73"/>
    <dbReference type="eggNOG" id="KOG4788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019911">
        <property type="term" value="F:structural constituent of myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013295">
        <property type="entry name" value="MAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF9">
        <property type="entry name" value="PLASMOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01884">
        <property type="entry name" value="MALPROTEIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="13">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO27038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="177" mass="19735" checksum="910A3065A19BBE09" modified="2016-06-08" version="1">MARRQHVNLELVLLSGLGFAASEAALMPIKLPIKPICTNPANVFGLLVWALIADTYYQAYAAYGWVMFVSVFFWLVTVILFVMYLLQLHLKLYMIPWPIVLVIFNAAATLLYITAFITCSASVKQTSWLVWEYNRRAAASFFACVTMIAYGASTFLSYQAWKGVGSNAATSQVTNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRI0</accession>
    <name>A0A151MRI0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0011815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005449">
        <property type="protein sequence ID" value="KYO27010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRI0"/>
    <dbReference type="STRING" id="8496.A0A151MRI0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585391" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO27010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="160" mass="17648" checksum="4C1E8C7AE2B3302A" modified="2016-06-08" version="1">MEGLGVLLFLAVCSGASSQIQLTQSRPEVRKPGESVKLSCKASGYTFTDYSMNWGRVCSQVQLLQATAAQEKPSGTLRLTCAVSGFSLTASGSVVSWIRQPPGKGLEWLCLIFWNDYKYYQDSMKSRLTISQDTSKSEVYLELRGLEARDSGTYYCAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRK4</accession>
    <name>A0A151MRK4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fractalkine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CX3CL1</name>
        <name evidence="7" type="ORF">Y1Q_0018202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005442">
        <property type="protein sequence ID" value="KYO27040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRK4"/>
    <dbReference type="STRING" id="8496.A0A151MRK4"/>
    <dbReference type="eggNOG" id="ENOG502SNIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048020">
        <property type="term" value="F:CCR chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070098">
        <property type="term" value="P:chemokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00272">
        <property type="entry name" value="Chemokine_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF183">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585396" evidence="5">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="6">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO27040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="13477" checksum="F72D98F2B5A9AB53" modified="2016-06-08" version="1">MKSSSVLRLILLLGLWILERLVAGQPKSFVGCATMCKGFTKELPLRLLKSYKKTDPSCPKSVIIFSTKKSREFCANPEESWVKVFINKAFQDYTFTAHNTKGYDGYFIISQILKEQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRY8</accession>
    <name>A0A151MRY8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">endothelin-converting enzyme 1</fullName>
            <ecNumber evidence="5">3.4.24.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0009051</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1.</text>
            <dbReference type="EC" id="3.4.24.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.71" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03005266">
        <property type="protein sequence ID" value="KYO27189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRY8"/>
    <dbReference type="STRING" id="8496.A0A151MRY8"/>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF127">
        <property type="entry name" value="EEF1AKMT4-ECE2 READTHROUGH TRANSCRIPT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="21">
        <location>
            <begin position="136"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="20">
        <location>
            <begin position="581"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO27189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="852" mass="95630" checksum="1E3859609017AC40" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSL7</accession>
    <name>A0A151MSL7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0013471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005173">
        <property type="protein sequence ID" value="KYO27449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSL7"/>
    <dbReference type="STRING" id="8496.A0A151MSL7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO27449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="127" mass="14547" checksum="FCE3FAFF971A60CC" modified="2016-06-08" version="1">MEQGLVTLLYKGLREELKNWGLITLLNFDYKLLAKVLAKQFKSILGAVIHKDQSCRVLGRQIHGALVQLRDALQLDRERRQSLAILNPDLEKAYDRVPHRFVPDAEADGCPSGLHQLDQDPLHRKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSQ4</accession>
    <name>A0A151MSQ4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apolipoprotein A-IV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005145">
        <property type="protein sequence ID" value="KYO27548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSQ4"/>
    <dbReference type="KEGG" id="amj:106737429"/>
    <dbReference type="PhylomeDB" id="A0A151MSQ4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585430" description="Apolipoprotein A-IV" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16780" checksum="34B3332892AC3B80" modified="2016-06-08" version="1">MELRAAVLALAVLGLAGSQAAPAGKGAAPRLRQLEEAINNIIKEVMQVTHDTAEWLKVSELVQELELQTRDLYDQLELGMSPELREAIHSTMRLVELPLWAMEPYLDTAMKQTAQALEHVEALGLDLPGALQAVTKWALELKEQLVGLPPISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MT87</accession>
    <name>A0A151MT87_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pulmonary surfactant-associated protein D isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SFTPD-1</name>
        <name evidence="9" type="ORF">Y1Q_0005243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Oligomeric complex of 4 set of homotrimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SFTPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MT87"/>
    <dbReference type="STRING" id="8496.A0A151MT87"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.360:FF:000001">
        <property type="entry name" value="Pulmonary surfactant-associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.360">
        <property type="entry name" value="SFTPD helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015097">
        <property type="entry name" value="Surfac_D-trimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF15">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09006">
        <property type="entry name" value="Surfac_D-trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57944">
        <property type="entry name" value="Triple coiled coil domain of C-type lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="255"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO27684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="379" mass="39763" checksum="A85709344679AEC2" modified="2016-06-08" version="1">MWSPWDCTKPGFSKAPEIRVRKLNNAAAFNFECFHCGDKIHCKSNSGRDGRDGKEGPKGEKGNPGLQGLKGSQGPPGKMGPAGPEGAKGSQGEKGSKGDVGDRGLQGVPGLKGDQGIRGPAGPKGDKGSSGEKGAKGEIGLQGTTGQQGLPGNSGSSGPKGDKGPVGEKGGKGDKGDRGLQGATGSQGPTGKTGFSGPKGDKGSQGEKGTKGDSGLSEINLLKIQVRTLEGKLNTLQNSFSKYKKVIMFPNGRIVGEKVFMTSGYESSFENLKQKCSQAGGQLAAPRNSAENAAIQQIVAMHNKAAYLGINDIQTEGQFRYLNGQAITYSNWLPREPNNDRGVEDCVEVFEHDHLRPRAVHDELLKETDTPIYCKVTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTU8</accession>
    <name>A0A151MTU8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO27933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTU8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="8145" checksum="A535468D30AB07DA" modified="2016-06-08" version="1">MKAHVSLNQLVTMMPPDLLPNHRAWQAEEANDLSKKEFTALIRKESKIDRENNQTKKSRKWHSNKFTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU37</accession>
    <name>A0A151MU37_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sentrin-specific protease 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">SUMO-1-specific protease 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sentrin/SUMO-specific protease SENP6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SENP6</name>
        <name evidence="19" type="ORF">Y1Q_0014220</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO28042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MU37"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090234">
        <property type="term" value="P:regulation of kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090169">
        <property type="term" value="P:regulation of spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.20:FF:000005">
        <property type="entry name" value="sentrin-specific protease 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.20:FF:000010">
        <property type="entry name" value="sentrin-specific protease 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000027">
        <property type="entry name" value="SUMO-specific peptidase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="18">
        <location>
            <begin position="666"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="272"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="798"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1083"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1085"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO28042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1115" mass="126014" checksum="262741E34128501A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUA2</accession>
    <name>A0A151MUA2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mas-related G-protein coupled receptor member H-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005047">
        <property type="protein sequence ID" value="KYO28103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUA2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11016" checksum="98DBCF308AFCA4DC" modified="2016-06-08" version="1">MQVLGWGGDCGPQVLKRKKGLCTGEGGPANVSRDFMMVGSYTNRQFKASISTAFQRVFEDTTDSTTQRSSVNRLSGETATEISDSTQSETLTSRDRISSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO28034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUA3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="77" mass="8544" checksum="A2405A8B29ECC4FA" modified="2016-06-08" version="1">MNAAQLPAAARGVPLPLSSALSGVERNPETGNNTKRMQTMRINIESAEPITCKQHPLGEMDEFSITRIQKQQNRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUJ2</accession>
    <name>A0A151MUJ2_ALLMI</name>
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        <submittedName>
            <fullName evidence="11">Olfactory receptor 1019-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0005118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005047">
        <property type="protein sequence ID" value="KYO28124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUJ2"/>
    <dbReference type="KEGG" id="amj:102571857"/>
    <dbReference type="eggNOG" id="ENOG502SHXT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9615015at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MUJ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15944">
        <property type="entry name" value="7tmA_OR5AR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO28124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="308" mass="34554" checksum="BBFB42D5F804DC8E" modified="2016-06-08" version="1">MAEGNGSTVTEFFLLGITDDPQMQVIFFVVFLSIYLVNVIGNLGMIALISHDHRLHTPMYVFLWHLSFCDLSYSSAIAPRMLADFLSKERAISFSGCSAQFYFFAAFVDTECYVLAVMAYDHCVAICNPLLYSSAMSKKLCIQLLARSYIAGMTNAVIHTTATFSLNFCGSNIINHFFCDVPPLLSLSCSDTHINEILLFAFAGFVEMSSLSVILISYLFILSAILRTRSAEGRHKAFSTCGSHFTGVTLFYGTVIFMYLRPTSVYSLDQNKWASVFYTVVIPMMNPLTYSLRNKDVKEAFKKLIKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV03</accession>
    <name>A0A151MV03_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8280" checksum="7CFAC7ADC208E736" modified="2016-06-08" version="1">MRTAESAAARSSRELWADICAALPGAEQAADAREAFADSFAGAGXXXXAPLEPRRSRGRRCRTPPCIWRRWKEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVL0</accession>
    <name>A0A151MVL0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Solute carrier family 12 member 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Y1Q_0017099</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004872">
        <property type="protein sequence ID" value="KYO28593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVL0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF54">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="12"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="289"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="418"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="619"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="568"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO28593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="78226" checksum="52CFFC2F547AD23B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXU9</accession>
    <name>A0A151MXU9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RNF19B</name>
        <name evidence="18" type="ORF">Y1Q_0018004</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RBR family. RNF19 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXU9"/>
    <dbReference type="STRING" id="8496.A0A151MXU9"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20355">
        <property type="entry name" value="Rcat_RBR_RNF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000001">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000004">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO29376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="498" mass="52887" checksum="B34C35CA262D01DC" modified="2016-06-08" version="1">MEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTCEREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPCPRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDISKHKRNLAIAGGVTLSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDINVGGTNAAIDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMALAGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSILNSYLPLDREGNSMEVQVDIESKPAKFRHNSGSSSVDDGSAPGRSNAGCSSASLPESKSSATKWSKEATAGKKCKGIKEVYYQLLDFTMGAKCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYM2</accession>
    <name>A0A151MYM2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CD2 antigen cytoplasmic tail-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TBC1D10B</name>
        <name evidence="18" type="ORF">Y1Q_0008879</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004652">
        <property type="protein sequence ID" value="KYO29574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYM2"/>
    <dbReference type="STRING" id="8496.A0A151MYM2"/>
    <dbReference type="eggNOG" id="KOG2221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.40:FF:000002">
        <property type="entry name" value="CD2 antigen cytoplasmic tail-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000001">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000008">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000007">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF17">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="16">
        <location>
            <begin position="498"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="GYF" evidence="17">
        <location>
            <begin position="1010"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="783"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="931"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO29574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1071" mass="114278" checksum="B6B056D28E4D1987" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZG5</accession>
    <name>A0A151MZG5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004458">
        <property type="protein sequence ID" value="KYO29912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZG5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="162" mass="16855" checksum="B1FE9AD6929DEA95" modified="2016-06-08" version="1">MYKLAQAWLHEASPAGRVRGEACGPGPCHTRGTRATSEGLSLAVSELQAVFEAGAAASPLCPVLPPARDRTGPEKTGRAQLAQGGSRQGPGSGEPATKEAGAEVPSWRPWQEARAKVAVTGLDVFAPLMTADGDGRGHWKSQITFNSREGSPIASLLSRSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZZ8</accession>
    <name>A0A151MZZ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fibronectin type III and SPRY domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FSD1</name>
        <name evidence="20" type="ORF">Y1Q_0000365</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">May be involved in microtubule organization and stabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomerization is required for binding to microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004368">
        <property type="protein sequence ID" value="KYO30057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059576011.1">
        <property type="nucleotide sequence ID" value="XM_059720028.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059576012.1">
        <property type="nucleotide sequence ID" value="XM_059720029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZZ8"/>
    <dbReference type="STRING" id="8496.A0A151MZZ8"/>
    <dbReference type="GeneID" id="102574947"/>
    <dbReference type="CTD" id="79187"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12901">
        <property type="entry name" value="SPRY_PRY_FSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000566">
        <property type="entry name" value="fibronectin type III and SPRY domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035742">
        <property type="entry name" value="SPRY/PRY_FSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF4">
        <property type="entry name" value="FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COS" evidence="19">
        <location>
            <begin position="115"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="174"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="292"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO30057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="506" mass="57117" checksum="4F563FEE46F9EC49" modified="2016-06-08" version="1">MRTSPGSPEHQPGPKEALRKIITTLAVKNEEIQNFIYALKQMLQNVEANSVKVQEDLEGEFQTLYSLLDELKENMLMKIKQDRASRTYELQNQLAACTKALESSEELLETANQTLQGAENHDFHQAAKQIKDSVTMAPAFRLSLKAKVSDNMSHLMVDFAQERRMLQALKFLPVPSAPEIDMAESLVADNCVTLVWKMPDEDSKIDHYVLEYRKTNFEGPPRVKEDQPWMVIEGIKQTEYTLSGLKFDMKYMNFRVKACNKAVAGEFSEPVTLETRAFMFRLDAGTCHQNLRVEELSVEWDAMGGKVQDIKAREKDSKGRTASPVNSPARCVQSPKRMPSARGGRDRFTAESYTVLGDTLIDGADHYWEVKYDRDSKAFGVGVAYRSLGKFDQLGKTSASWCLHLNNWLQVSFTAKHNNKAKVLDVPVPDCIGVYCNFHEGFLSFYNAKTKQLLHTFKAKFTQPVLPAFMVWCGSFHVYSGLQVPSSVKSLQKRNSTTSSSNASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N066</accession>
    <name>A0A151N066_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004313">
        <property type="protein sequence ID" value="KYO30142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N066"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="100" mass="11143" checksum="524631119A16B735" modified="2016-06-08" version="1">MWLAGAEKDVVCAGVQASLCQFGEEEMGAICAWRYGVSWWNRLCEFGGEEMGAMCAWSYAVRLSNRLQWTEVLVSCCVVVVGVERQRSGRCGVEVEHLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0E6</accession>
    <name>A0A151N0E6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0022441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004278">
        <property type="protein sequence ID" value="KYO30222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0E6"/>
    <dbReference type="STRING" id="8496.A0A151N0E6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20109">
        <property type="entry name" value="MBT_SCML2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09578">
        <property type="entry name" value="SAM_Scm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000018">
        <property type="entry name" value="Polycomb protein scmh1 isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000016">
        <property type="entry name" value="polycomb protein SCMH1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.190">
        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047531">
        <property type="entry name" value="SAM_Scm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033763">
        <property type="entry name" value="SCML2_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021987">
        <property type="entry name" value="SLED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038348">
        <property type="entry name" value="SLED_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF84">
        <property type="entry name" value="SEX COMB ON MIDLEG-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17208">
        <property type="entry name" value="RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12140">
        <property type="entry name" value="SLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="MBT" evidence="8">
        <location>
            <begin position="109"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="8">
        <location>
            <begin position="215"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="734"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO30222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="805" mass="88448" checksum="D7F1F1F7CDC66DE4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N463</accession>
    <name>A0A151N463_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclease HARBI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0004727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004069">
        <property type="protein sequence ID" value="KYO31578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N463"/>
    <dbReference type="KEGG" id="amj:106737796"/>
    <dbReference type="OrthoDB" id="1912480at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF206">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="110"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO31578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="326" mass="35088" checksum="BD4E00F908460D63" modified="2016-06-08" version="1">MSAGTFRALCAELAPALRRQRTRMRLPLSVEKRVAIALWKLATAACYRAVGAQFGVGRSTAGAVVLEVCRAIQRVLLRRAVAWPGDARELLAGFGALGLPRCAGALGLAHTPIQCPPRQAADYINARGYYSMALQVLVDHRGRFTHVSAGWPGKAHPARVLRRSGLYRRGQQGALFPAGATPLRVGGVAVPLVVAGSAAHPLLPWLMTPFGEAAGAQGRFDAALARCRQPAERALARLRGRWRCLTARNDCAVDNLPRLVSACCVLHNLCERRGEPFDEAWAAEAQRLGASFQQPEARPEAPAEPTSPGARVRDALCAYMESQAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4Y1</accession>
    <name>A0A151N4Y1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">POZ-, AT hook-, and zinc finger-containing protein 1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PATZ1-1</name>
        <name evidence="10" type="ORF">Y1Q_0022774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4Y1"/>
    <dbReference type="STRING" id="8496.A0A151N4Y1"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000780">
        <property type="entry name" value="myc-associated zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000147">
        <property type="entry name" value="POZ-, AT hook-, and zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000404">
        <property type="entry name" value="POZ-, AT hook-, and zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001107">
        <property type="entry name" value="POZ-, AT hook-, and zinc finger-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16637">
        <property type="entry name" value="zf-C2H2_assoc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO31675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="555" mass="60642" checksum="09E941041D0F2E55" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N577</accession>
    <name>A0A151N577_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">F-box/WD repeat-containing protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-box and WD-40 domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FBXW8</name>
        <name evidence="13" type="ORF">Y1Q_0022828</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N577"/>
    <dbReference type="STRING" id="8496.A0A151N577"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031467">
        <property type="term" value="C:Cul7-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22134">
        <property type="entry name" value="F-box_FBXW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000025">
        <property type="entry name" value="F-box and WD repeat domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000308">
        <property type="entry name" value="F-box and WD repeat domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000428">
        <property type="entry name" value="F-box and WD repeat domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF11">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="12">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO31749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="501" mass="56243" checksum="2AEBC0C36C0CE02E" modified="2016-06-08" version="1">MLIRDLNEINEIPFFDVQLPYELALKIFQYLGRIELGKCAQVSRTWKVLAEDEVLWYRLCQQEGYLLDNSISDGSCWKLALKDCRAKEHTLRTNWKNRVGAVSQLQYELGKILCSVHSCDGVVISGYTSGDVRLWDTRTWDYTAPILESMHGAAEPGPQPHVSFVRINSSLAVAAYEDGTINVWSLMIGREPIHRYQHNQKLQALALGLEGAAIASASGFQVKVESSDDRGYWQTTAEFEIQKLVNFLQLVPGVIGSPVTLAAAEDVVYLLKAEQPGKILHSVYGQPVTCLDVSANEAAFGVKGFGWLLNETNKILLYNLETGQCVTQLGSSLGDFTCVNLQDSPPYMLVTGNKDRRVRVYDLRQNQSLCSLYAHHLGVSAVQMDDWKIVSGGEEGLVCVWDQRMGTKLWEIHARHPVRYIWFNSHSLITANIPDEKNPRGASIMDDDLTAHRRHRGIIYAYEFSVDQLAVESVLPICRSSYDEAIGYNYNIGLSVPYDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5T9</accession>
    <name>A0A151N5T9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5T9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="7329" checksum="4B7543AB56DBE7AC" modified="2016-06-08" version="1">MSQSSAGLGRAARGHGAGAGRGAARHGTGEEHRTDRVIAEAVQDGFTLPQVLALRLSWSAGADRMVVVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5U2</accession>
    <name>A0A151N5U2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HEATR6</name>
        <name evidence="4" type="ORF">Y1Q_0007167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5U2"/>
    <dbReference type="STRING" id="8496.A0A151N5U2"/>
    <dbReference type="eggNOG" id="KOG4535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025283">
        <property type="entry name" value="DUF4042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13251">
        <property type="entry name" value="DUF4042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4042" evidence="3">
        <location>
            <begin position="345"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO32178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1100" mass="121180" checksum="EEA9E087FF9AAED3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6L2</accession>
    <name>A0A151N6L2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0020343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6L2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO32381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="210" mass="23379" checksum="4B67EFE95E0115EC" modified="2016-06-08" version="1">MSQKVKARSLVVTEQEADTSNMHAPNWTQEELQDLIDSCSEESIIDRLENRRNKPVYVAIAKAMQAQGHHCDWTQLQCKIKALRSEFYHAKDANSRFGAGCTVAPFYDQLSIILSKDAGDTPGMVTFRTKVEEEKEEESTPTEAAPPETCIMGMSEEYGDCSVLLVDGHCQEEKQVTLQLIPVLASPSTPGSSTDQLEEEGRNGEKPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6T5</accession>
    <name>A0A151N6T5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transportin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TNPO2</name>
        <name evidence="9" type="ORF">Y1Q_0020792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003954">
        <property type="protein sequence ID" value="KYO32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6T5"/>
    <dbReference type="STRING" id="8496.A0A151N6T5"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="996" mass="111574" checksum="C233BF7E8DC03DC1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N745</accession>
    <name>A0A151N745_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003905">
        <property type="protein sequence ID" value="KYO32664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N745"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="162" mass="17769" checksum="E746CB48172E86AD" modified="2016-06-08" version="1">MQEEVSQSRFNLSPYTGKLRDTGGFHSANLLLELWRPLTAEISVLCLCHMPSGRRRKDKKGPCEVLFCLRCIKNGKGHKGGKCSSQGEREMSIKLLSGTHVGSESEASPCWQGLGACGDTPTPSNAASWEDFQKRFTLSCTGREASTWVLSGAFSQDLLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N831</accession>
    <name>A0A151N831_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MMGT1</name>
        <name evidence="11" type="ORF">Y1Q_0009360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Early endosome membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006268248.1">
        <property type="nucleotide sequence ID" value="XM_006268186.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N831"/>
    <dbReference type="STRING" id="8496.A0A151N831"/>
    <dbReference type="GeneID" id="102558407"/>
    <dbReference type="KEGG" id="amj:102558407"/>
    <dbReference type="CTD" id="93380"/>
    <dbReference type="eggNOG" id="KOG3918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N831"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585814" description="Membrane magnesium transporter" evidence="10">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO32759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="133" mass="14821" checksum="C54AAB1B24C2EDE7" modified="2016-06-08" version="1">MAAASLWKGLVGVGLFALAHAAFSAAQHRSYMRLTEKEDETLPIDIVLQTLLAFAVTCYGIVHIAGEFRDMDATSELKNKTFDTLRNHPSFYVFNHRGRVLFQSPDTANSSSNQDALSSSSSLKFRKLEPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8G6</accession>
    <name>A0A151N8G6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-like phospholipase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0014920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8G6"/>
    <dbReference type="STRING" id="8496.A0A151N8G6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF23">
        <property type="entry name" value="OMEGA-HYDROXYCERAMIDE TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="73"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="328"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="363"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="625" mass="69647" checksum="E5575EFA681AA571" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8H1</accession>
    <name>A0A151N8H1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8H1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="94" mass="10772" checksum="9153D971043B8BDD" modified="2016-06-08" version="1">MIAELSREDAEEPIPAIQSASFSVPQFLQSAADKIIRIFHMALHLFKEIERLQVKLILDLGKGNCLMDRKGWGWMSGSRIAFLVLLLLYFYDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8I0</accession>
    <name>A0A151N8I0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F-box/WD repeat-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FBXW7</name>
        <name evidence="12" type="ORF">Y1Q_0016727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003818">
        <property type="protein sequence ID" value="KYO33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8I0"/>
    <dbReference type="STRING" id="8496.A0A151N8I0"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001205">
        <property type="term" value="P:negative regulation of osteoclast development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903378">
        <property type="term" value="P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901800">
        <property type="term" value="P:positive regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000060">
        <property type="term" value="P:positive regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001944">
        <property type="term" value="P:vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22133">
        <property type="entry name" value="F-box_FBXW7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000004">
        <property type="entry name" value="F-box/WD repeat-containing protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000032">
        <property type="entry name" value="F-box/WD repeat-containing protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF5">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="236"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="455"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="495"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="535"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="578"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="665" mass="74122" checksum="4FEC58241AEEBFD2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N988</accession>
    <name>A0A151N988_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ubiquitin-related modifier</fullName>
            <shortName evidence="6">SUMO</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SUMO1</name>
        <name evidence="8" type="ORF">Y1Q_0008617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ubiquitin family. SUMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
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            <end position="83"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50053"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO33390.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="10874" checksum="31C8C2526CF79404" modified="2016-06-08" version="1">MPKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRITDNHTPKELGMEEEDVIEVYQEQTGGKKTVQLEMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N994</accession>
    <name>A0A151N994_ALLMI</name>
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        <name evidence="8" type="primary">ALS2</name>
        <name evidence="8" type="ORF">Y1Q_0008612</name>
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        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014594185.3"/>
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    <dbReference type="KEGG" id="amj:102566519"/>
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    <dbReference type="eggNOG" id="KOG1426">
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    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13269">
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.1050.80:FF:000005">
        <property type="entry name" value="alsin isoform X1"/>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="Alsin-like_PH"/>
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        <property type="entry name" value="DBL_dom_sf"/>
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        <property type="entry name" value="HA_Alsin"/>
    </dbReference>
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        <property type="entry name" value="MORN"/>
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        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
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    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
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        <property type="entry name" value="VPS9_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR46089:SF3">
        <property type="entry name" value="ALSIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46089">
        <property type="entry name" value="ALSIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25582">
        <property type="entry name" value="DH_Alsin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HA_Alsin"/>
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        <property type="entry name" value="PH_DOMAIN"/>
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        <property type="entry name" value="RCC1_2"/>
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        <property type="entry name" value="RCC1_3"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="169"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="570"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="680"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="907"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="7">
        <location>
            <begin position="1503"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1647" mass="181798" checksum="D6619C4477B67C3A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9H2</accession>
    <name>A0A151N9H2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9H2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="92" mass="10323" checksum="E425ED554E6B5FFA" modified="2016-06-08" version="1">MDSENYCQLWITPLYLARTPAIGPYRLSDFFLQLTLSTAVDFYTGLLKCCQSLSPIRQTMGKKKYPGYAVINVFRLDLCVAGFGLNKAGVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9Z2</accession>
    <name>A0A151N9Z2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPATS2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPATS2L</name>
        <name evidence="3" type="ORF">Y1Q_0008780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9Z2"/>
    <dbReference type="STRING" id="8496.A0A151N9Z2"/>
    <dbReference type="eggNOG" id="ENOG502S51R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009816">
        <property type="entry name" value="SPATS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15623:SF8">
        <property type="entry name" value="SPATS2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15623">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07139">
        <property type="entry name" value="SPATS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="507" mass="56726" checksum="7B17628686171F13" modified="2016-06-08" version="1">MDGSAAQVLKEWNMTGKKKNNKRKRSKSKQYQGNKDAKDKDDGTEKVSLEPHGIYGCHLNGCDKDTSSSDSANEKSEKMSHEDKNPGFADVIQMHPEIADKGLEHKRVGVDLNHKSINGTEQCDTFQSSVQPHHNLGRPKSKASIVKSSNPAAHLEKKPDDSIKKRGPNIEKSVKDLQRCTVSLTRYRMMIKEEVDNSVKKIKAAFADLHSCIIDKEVSLMAEIDKVKEEAMEILNARQKKAEELKRLTDLASQMAEAQLSELRAEIKHFVSERKYDEELGRSARFTCDIEQLKTQIQQCGEISHPKNNYSSRTSCNSVLSSVTSNLSTGKQNTHPRKASSNMKNSESKTGSTKMPIYVPSNPTEPTTQVIPMNKQNGPFIQRRRFNPQHQSFRLNGSGKSQSTNETDQNNIKTGSRSEHRRQQHNNFRPKNKGATKNQDPSAATRTTENLTHSEKTRRKHHTPDSTEPRSFRNSVARVSQCNLCPASIEVSADATVLSVPAVTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBY1</accession>
    <name>A0A151NBY1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Immunoglobulin C1-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003549">
        <property type="protein sequence ID" value="KYO34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBY1"/>
    <dbReference type="STRING" id="8496.A0A151NBY1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin C1-set" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="156" mass="17214" checksum="F78C82902792662C" modified="2016-06-08" version="1">MEEESDPKEPSVLLMKSKASSDHRVKAACLAKDFYPKNVTFHFGVSHEVVYEQKDPVLSANGKYSAIKVAEFNENEEVDCSVQHTEKNFTAQSSQPAGSASMPATTTKLCDVSNATAEEENPETVNMLPLTVLGLRFLFAKSIAFNTLMTIKLFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NC81</accession>
    <name>A0A151NC81_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0018060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003487">
        <property type="protein sequence ID" value="KYO34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NC81"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB-related" evidence="3">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="86" mass="9712" checksum="BD93B2F56019F782" modified="2016-06-08" version="1">MLSAGTLSRAEQQPPEEGPVILELQRTSPGRLEERSSLTSEPGQVQRGQGRPPEQGESLELQEVFEDVAVYFTQREWELLDDNDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCG7</accession>
    <name>A0A151NCG7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0007733</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003549">
        <property type="protein sequence ID" value="KYO34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCG7"/>
    <dbReference type="KEGG" id="amj:102565202"/>
    <dbReference type="eggNOG" id="ENOG502SI3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9902777at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15912">
        <property type="entry name" value="7tmA_OR6C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000010">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047132">
        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF53">
        <property type="entry name" value="OLFACTORY RECEPTOR 6J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="40"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="333" mass="37140" checksum="0D72F69274FC7F00" modified="2016-06-08" version="1">MENDTTRVTEFVLLGFPIGHKEEILLSALLLAMYILTLTGNLVILGIVPTSRQLHTPMYYFLCNLSVLDIFFTSVIIPQFISNLLSGDKTISFTDCITQLYFYFFLGTVEFFLLTSMSYDRYAAICTPLHYHTLMNGWVCTHMVLGCWMGGFLSVIFPTILISRLPYCRSNVIDHFFCDSGPLLELSCSDTRMIELIDFMLSSVVILCSLVLTIISYTYIISTILRIPTSMGRRKAFNTCASHLTIISISCGITIFIYVTPSQKGTLGLQKIPAVLTTIVCPFLNPFIFTLRNDTAKTALKQCFIWLKDVVVQGAVKCQCSGAAVSKAACGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NED5</accession>
    <name>A0A151NED5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NED5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8661" checksum="FD279A3F904F8670" modified="2016-06-08" version="1">MIENSSAVISAVLVVDDIWIIQVSLALCRFYMCKFTHVMNLLIPKIWYNADLRRRGGVRSSYAEVNKMEVALNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEZ9</accession>
    <name>A0A151NEZ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEZ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="160" mass="18642" checksum="74F42C955F022139" modified="2016-06-08" version="1">MEDPNLAPYANMQPAAMGPAEVLGQNLQVPTQILDSQQQMMDRQQDWLWHSLASFKVPKMTKDDDPEAYIKAFEQHALMMGLEQDYWASQLGALVIGKAQAVYQALSREDAWDYELEKQAILYRLEINPEHYRRLFRAKKGPDERRPRVLLQLLRDLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGA4</accession>
    <name>A0A151NGA4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0008560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003083">
        <property type="protein sequence ID" value="KYO35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGA4"/>
    <dbReference type="STRING" id="8496.A0A151NGA4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF234">
        <property type="entry name" value="PROTOCADHERIN GAMMA-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="96"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="252" mass="27721" checksum="55C4AE5A5E001B8F" modified="2016-06-08" version="1">MQKGSFVGNIAQDLGLEAKELSERGVSVVSRGRTQYFALNVKSGHLITAERLDREQLCGRAEKCLLNCEVIVQHDMKMYGVEVEIVDINDNAPNFQTGEMELKVSETTAPGSRFPFRNVQDPDLGTNSLQSYKLSSNKHFSLKVQTASGGFKYPELVLEKPLDREQQAAHDLILTATDGGDPVRSGTARIHVVVLDANDNAPVFSQPLYRVSVRENVPVGTTVATVKATDLDEGDRRYNGLQEPGLRGIHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGX6</accession>
    <name>A0A151NGX6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGX6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="128" mass="14735" checksum="F8C2A56F21AB9A67" modified="2016-06-08" version="1">MCLFSQCHPQDQEVSWVKCFEGVVLYCEALKSRPCGISNLHALRQADKRKSCKRSRSQLTSDTISSVQGQKKRMPKQCNILTLSFLHTCWFPLSSASQRAIYWERYYSVQTHAGAVAPRTDELSFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NH70</accession>
    <name>A0A151NH70_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003015">
        <property type="protein sequence ID" value="KYO36162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NH70"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO36162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9552" checksum="25081A4168747830" modified="2016-06-08" version="1">MDHNSSVTGFVQLQNKELISSLKTLQSKVPGTVARTHRNWTHLLGHCSCLISLSPQVPGTVARMHQNQTHRLGHSSQLISLPLQCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NI17</accession>
    <name>A0A151NI17_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Stabilin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">STAB1</name>
        <name evidence="19" type="ORF">Y1Q_0024192</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NI17"/>
    <dbReference type="GeneID" id="106736777"/>
    <dbReference type="KEGG" id="amj:106736777"/>
    <dbReference type="CTD" id="55576"/>
    <dbReference type="eggNOG" id="KOG1218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NI17"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030169">
        <property type="term" value="F:low-density lipoprotein particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000001">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000040">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000278">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000005">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000017">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000018">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000020">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000021">
        <property type="entry name" value="Stabilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056806">
        <property type="entry name" value="EGF_STAB1-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24038">
        <property type="entry name" value="STABILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24038:SF0">
        <property type="entry name" value="STABILIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24887">
        <property type="entry name" value="EGF_STAB1-2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586088" evidence="15">
        <location>
            <begin position="19"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2467"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="111"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="17">
        <location>
            <begin position="374"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="17">
        <location>
            <begin position="520"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="738"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="828"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="869"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="912"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="955"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="17">
        <location>
            <begin position="996"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="17">
        <location>
            <begin position="1139"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1347"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1433"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1472"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1514"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1556"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="17">
        <location>
            <begin position="1597"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="17">
        <location>
            <begin position="1741"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1958"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2082"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2123"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="18">
        <location>
            <begin position="2198"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="17">
        <location>
            <begin position="2311"/>
            <end position="2451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2511"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2511"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2545"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1375"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1437"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1988"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2220"/>
            <end position="2289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2244"/>
            <end position="2265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO36451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2556" mass="278545" checksum="EEC08881690C7201" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NI30</accession>
    <name>A0A151NI30_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NI30"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO36463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="116" mass="13003" checksum="F4E1FC94AF4924AC" modified="2016-06-08" version="1">MSNLGVEVTQENDLVISGDGEKGIVEIRVEPFLDFFTGIQSWSICTDDSGKLVWLEVQVKGHQPFIDTRREFRVHISDLVSDGKTNSMDMGVTIWFLIPEEELGFAESSNVDAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NI57</accession>
    <name>A0A151NI57_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 52P1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0017296</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002986">
        <property type="protein sequence ID" value="KYO36185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NI57"/>
    <dbReference type="KEGG" id="amj:102558021"/>
    <dbReference type="eggNOG" id="ENOG502QV28">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15951">
        <property type="entry name" value="7tmA_OR52R_52L-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000006">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF38">
        <property type="entry name" value="OLFACTORY RECEPTOR FAMILY 52 SUBFAMILY S MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO36185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="310" mass="34728" checksum="571862F1DCA95861" modified="2016-06-08" version="1">MSTLNSSTQSPTTFILIGIPGLETVHIWISIPFCSMYIMAIVGNCTILFIIKTEPSLHKPMYLFLCMLSVTDLVLSSSTLPKMLSIFWFDARQIDFGACLTQMFFIHSFTAMESGFFLAMAYDRYMAICNPLRHATVLTNVIIAKIALAVVVRGAVFFFPHPFLVSSLPFCKTNIISHSYCEFMALVKLACADTTARGAYSLSLAFLIGGFDVFFITLSYTLILWTVTSLPSKEASLKAFSTCSSHICVILVFYTTAVFSFLTHRFGHNVAPHIHILVANMYLLVPPMLNPIIYGVRTRKIRERVARLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIE6</accession>
    <name>A0A151NIE6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIE6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO36530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="90" mass="10448" checksum="288B6155E33823F1" modified="2016-06-08" version="1">MFTRHWTETTDSPEKLVHEAKTHGRILGHDKNLAYFYPASPSKERMGEVSPAPDLRVPTWQSTRFCYDTRSYSKRTELSSWHLIFGSGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJ69</accession>
    <name>A0A151NJ69_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spexin isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SPX</name>
        <name evidence="6" type="ORF">Y1Q_0024389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJ69"/>
    <dbReference type="STRING" id="8496.A0A151NJ69"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904306">
        <property type="term" value="P:positive regulation of gastro-intestinal system smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028126">
        <property type="entry name" value="Spexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28590">
        <property type="entry name" value="SPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28590:SF1">
        <property type="entry name" value="SPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15171">
        <property type="entry name" value="Spexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO36729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="146" mass="16680" checksum="A03E8AC256634D5F" modified="2016-06-08" version="1">MTLENNLLAFLQGYFIDVTADDNLIYNKLPKGLRRLTASAMALFLAASLISYSWSAPQGHFQRRNWTPQAMLYLKGAQGRRFISDESQRKDLYDRLQLETRSQNSNPVSLSEAAALFLSSFRKAQEEAEEETSDHPGYLTNNLLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKH9</accession>
    <name>A0A151NKH9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002781">
        <property type="protein sequence ID" value="KYO37303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKH9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="92" mass="10078" checksum="005F6CFEC852CC0A" modified="2016-06-08" version="1">MDLQKSRLLLRVQLGPQVAQAPILPVTHPPRINLQQTRSPPSGPGSLTPALLTLQQKESGHAWTSGDRGMEEMQETTHGPRESREAGKDFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNR4</accession>
    <name>A0A151NNR4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Apoptosis-inducing factor 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Programmed cell death protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">AIFM1</name>
        <name evidence="32" type="ORF">Y1Q_0007231</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>A + NADH + H(+) = AH2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11356"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="25">Monomer (oxidized form). Homodimer (reduced form). Upon reduction with NADH, undergoes dimerization and forms tight, long-lived FADH2-NAD charge transfer complexes (CTC) resistant to oxidation. Also dimerizes with isoform 3 preventing its release from mitochondria. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Interacts with PRELID1. Interacts with CHCHD4; the interaction increases in presence of NADH. Interacts with processed form of PARP1 (Poly [ADP-ribose] polymerase 1, processed C-terminus); interaction is mediated with poly-ADP-ribose chains attached to PARP1, promoting translocation into the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259906.2">
        <property type="nucleotide sequence ID" value="XM_006259844.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNR4"/>
    <dbReference type="STRING" id="8496.A0A151NNR4"/>
    <dbReference type="GeneID" id="102568057"/>
    <dbReference type="KEGG" id="amj:102568057"/>
    <dbReference type="CTD" id="9131"/>
    <dbReference type="eggNOG" id="KOG1346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000007">
        <property type="entry name" value="Putative apoptosis-inducing factor 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029324">
        <property type="entry name" value="AIF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14721">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01353">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="21 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="30">
        <location>
            <begin position="125"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial apoptosis-inducing factor C-terminal" evidence="31">
        <location>
            <begin position="455"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="503"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00055744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00062987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00067295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00078456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF14721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KYO38105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="603" mass="65545" checksum="05354DDAA1A45839" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQN3</accession>
    <name>A0A151NQN3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">V-set domain-containing T-cell activation inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0000101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002379">
        <property type="protein sequence ID" value="KYO39088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQN3"/>
    <dbReference type="STRING" id="8496.A0A151NQN3"/>
    <dbReference type="KEGG" id="amj:106738022"/>
    <dbReference type="OrthoDB" id="9898017at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NQN3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF148">
        <property type="entry name" value="SELECTION AND UPKEEP OF INTRAEPITHELIAL T-CELLS PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586279" evidence="7">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO39088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="182" mass="20740" checksum="D529B704345D4450" modified="2016-06-08" version="1">MKRAGVLHLITCLLLWFVPGVVPQPTLYQAINGDTAILPCANQTSEKLDMKKYSIYWQIESSVVHFFHNGAESLNNQLKRYQNRTRLFLDQLEHGNFSLILSQVQHDDEAVYTCIYRNGETRAIGKHAVRLNVSDIQPKEGNSLYLGQPSHHPNCSSNAKDSDAFVFSFHLLVVIMAWILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSA8</accession>
    <name>A0A151NSA8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chemerin-like receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Chemokine-like receptor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CMKLR1</name>
        <name evidence="18" type="ORF">Y1Q_0018723</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the chemokine-like receptor (CMKLR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSA8"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004875">
        <property type="term" value="F:complement receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15116">
        <property type="entry name" value="7tmA_CMKLR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000034">
        <property type="entry name" value="G-protein coupled receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002258">
        <property type="entry name" value="CML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000826">
        <property type="entry name" value="Formyl_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225:SF49">
        <property type="entry name" value="CHEMERIN-LIKE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225">
        <property type="entry name" value="CHEMOTACTIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01126">
        <property type="entry name" value="DEZORPHANR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="105"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO39674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="406" mass="46157" checksum="DC57D4321AF1D839" modified="2016-06-08" version="1">MQLGRALPAFSHLCPQASDQAFPAAQGVDEAPATGTLRAELKKYWIEKIMEIYNYSEYDYDYGNVSDIDYSSYSLGPSSLHNTEEIIRILSVVIYSITCLLGIVGNGLVIAIIIFKMKKSVNAIWFLNLAAADFLFSVFLPLNIAYTAMKYNWIFGTAMCKLNSYLLNLNMYTSVFLLTMISIDRYLLVFFPIWSQNHRTPKLACLVCFIIWTISFMMSSPSLIFRDTEHVGQNVVCFSNFSLSSNKSYHSLGVMRHKMVTVTRFLAGFVIPITIITLCYIRIVCKLKNSRLTKSKKPFKIIVTIIVTFFLCWSPYHILHFLEMQPHKTLLSVLEVGIPITTALATFNSCMNPVLYVFMGQDFKKFKISVFSRLVNAISEDTAHSSLVHRSFSKTVSMTEKETILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSD1</accession>
    <name>A0A151NSD1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase RNF34</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">RING finger protein 34</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase RNF34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">RNF34</name>
        <name evidence="26" type="ORF">Y1Q_0018770</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019342416.1">
        <property type="nucleotide sequence ID" value="XM_019486871.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSD1"/>
    <dbReference type="STRING" id="8496.A0A151NSD1"/>
    <dbReference type="GeneID" id="102565152"/>
    <dbReference type="CTD" id="80196"/>
    <dbReference type="eggNOG" id="KOG4275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15769">
        <property type="entry name" value="FYVE_CARP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16706">
        <property type="entry name" value="RING-HC_CARP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.140:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF34 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000110">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF34 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049320">
        <property type="entry name" value="CARP1_2_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049323">
        <property type="entry name" value="CARP1_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055111">
        <property type="entry name" value="RNF34_RFFL_HeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057299">
        <property type="entry name" value="RNF34_RFFL_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21272">
        <property type="entry name" value="FYVE_CARP1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22968">
        <property type="entry name" value="RNF34L-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23632">
        <property type="entry name" value="SAP_RNF34_RFFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="14 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="25">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO39746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="345" mass="38063" checksum="CF9BCC6FA99701A0" modified="2016-06-08" version="1">MWASCCGLLNEVMGTGAVRGQQSGFGGGAGPFRFAPNTDFSACPSSTGGADIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLILRNIPTDTCREKDDLVDLVLCHHGVHSEESADTSSLHSARSQTSSIFAHPFSMSVSVSSSQGEFASRRGSAGNGTLLQGQAETPSANEDDDAAEEQTPGLSRKRARASLSDISSLEDIEGLNVRQLKEILARNFVNYSGCCEKWELVEKVNRLYRESEENHKTQGEKMQLNDNDDNLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NT26</accession>
    <name>A0A151NT26_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dapper-like protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0006459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002115">
        <property type="protein sequence ID" value="KYO39996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NT26"/>
    <dbReference type="eggNOG" id="ENOG502RE0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="177" mass="19147" checksum="55C64892A13EB9B3" modified="2016-06-08" version="1">MPACQPEALARGRGAGERLYRGKHASRELVRAAEGPERGWLGPRELLRRLSLRRRREGSHRCGSEGNVCPAAPGRPKWASVLEISSVRAAEPCLPPRRRPLALSTDSCFLGSGSTCSLGEEDAGSLAEEWRPPASGRALTLPTGDPGGTKLQRARSLKELKRMVRLSLRPAAHKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVE8</accession>
    <name>A0A151NVE8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Catenin delta-1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CTNND1</name>
        <name evidence="12" type="ORF">Y1Q_0012231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001868">
        <property type="protein sequence ID" value="KYO40734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVE8"/>
    <dbReference type="STRING" id="8496.A0A151NVE8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000007">
        <property type="entry name" value="ARVCF, delta catenin family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF6">
        <property type="entry name" value="CATENIN DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="478"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="521"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="774"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="919"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="919"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="939"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO40734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="996" mass="111403" checksum="26B975D850DE1A21" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW05</accession>
    <name>A0A151NW05_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0009445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001862">
        <property type="protein sequence ID" value="KYO40769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NW05"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO40769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="275" mass="30603" checksum="346114544156A832" modified="2016-06-08" version="1">MANLLILMAIRLDCALHTPMYFFLFTLSLSETCYTFVVIPNMLATLLSGGKPICLVGCALQMFFFLSFASTNCSLLAVMGYDRYVAICHPLHYSELMNLRICLWFAASCLFFGFLIPGIEVYLIFNLPYCGPNRIDHFFCDSGPVLQLACTDSKVPKIVVFAGGLLFIIGALLLILLSYVFILSAILKISSAQGRHKAFSTCAAHITVVIVHYGCAGIVYLRPKSAHSLEQDKLIAVSYTVFTPLLNPMMYSLRNKEVRLALRKTMTSIFCPQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWK4</accession>
    <name>A0A151NWK4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pseudouridine-5'-phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Haloacid dehalogenase-like hydrolase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Haloacid dehalogenase-like hydrolase domain-containing protein 1A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PUDP</name>
        <name evidence="13" type="ORF">Y1Q_0022525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03001669">
        <property type="protein sequence ID" value="KYO41113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014455826.1">
        <property type="nucleotide sequence ID" value="XM_014600340.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWK4"/>
    <dbReference type="STRING" id="8496.A0A151NWK4"/>
    <dbReference type="GeneID" id="102568706"/>
    <dbReference type="KEGG" id="amj:102568706"/>
    <dbReference type="CTD" id="8226"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07529">
        <property type="entry name" value="HAD_AtGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045228">
        <property type="entry name" value="Gpp1/Gpp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO41113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="230" mass="25819" checksum="4B9B238D43B5772E" modified="2016-06-08" version="1">MAASRRPAPVTHLLFDMDGLLLDTERLYTVVFQEICERFGKAYTWEVKSLVMGKKALEGAQIIRDTLELPMTKEELLHESKMKQEKIFPSAALMPGVEKLICHLHQHNIPIAVATSSAGETFEMKTIKHKGFFSFFNHIVLGDDPEVKNGKPQPDVFLVCAKRFHPAPPPEKCLVFEDSPLGVKAALTAGMQVVMIPDENLKQDLTKEATLVLKSMEDFKPELFGLPPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXZ9</accession>
    <name>A0A151NXZ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BET1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BET1L</name>
        <name evidence="13" type="ORF">Y1Q_0006377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274947.2">
        <property type="nucleotide sequence ID" value="XM_006274885.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXZ9"/>
    <dbReference type="STRING" id="8496.A0A151NXZ9"/>
    <dbReference type="GeneID" id="102562745"/>
    <dbReference type="KEGG" id="amj:102562745"/>
    <dbReference type="CTD" id="51272"/>
    <dbReference type="eggNOG" id="KOG3385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NXZ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000038">
        <property type="entry name" value="BET1-like protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO41623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="12432" checksum="85D1D7CBC2836F65" modified="2016-06-08" version="1">MAEWGRGQGQNGMDDMLDVENKHMADNLATKVTRLKSLALDIDKDAEDQNHYLDGMDSDFMSVTGLLTGTGKRFSSMTRSGRDNRKLLCYVSAGLIVVFFILYYLVSKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0U6</accession>
    <name>A0A151P0U6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phospholipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PLTP</name>
        <name evidence="11" type="ORF">Y1Q_0005976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001407">
        <property type="protein sequence ID" value="KYO42520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260203.1">
        <property type="nucleotide sequence ID" value="XM_006260141.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019339697.1">
        <property type="nucleotide sequence ID" value="XM_019484152.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0U6"/>
    <dbReference type="STRING" id="8496.A0A151P0U6"/>
    <dbReference type="GeneID" id="102561607"/>
    <dbReference type="KEGG" id="amj:102561607"/>
    <dbReference type="CTD" id="5360"/>
    <dbReference type="eggNOG" id="KOG4160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8862579at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P0U6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120017">
        <property type="term" value="F:ceramide transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904121">
        <property type="term" value="F:phosphatidylethanolamine transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035627">
        <property type="term" value="P:ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034375">
        <property type="term" value="P:high-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00025">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000001">
        <property type="entry name" value="Phospholipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000001">
        <property type="entry name" value="phospholipid transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030675">
        <property type="entry name" value="BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017954">
        <property type="entry name" value="Lipid-bd_serum_glycop_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF16">
        <property type="entry name" value="PHOSPHOLIPID TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002417">
        <property type="entry name" value="Lipid_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00400">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586571" evidence="8">
        <location>
            <begin position="18"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="10">
        <location>
            <begin position="258"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002417-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO42520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="487" mass="54391" checksum="CE8E791D6E67A0C4" modified="2016-06-08" version="1">MALRSLLLLALPCLVAATAPGCKIRITSKGLDLVKQEGLRFVEQELEHISIPDLHGKEGQFHYNISQVKVMALHLALSDLHFQPQQHIAFNINNASISLRFRRQLLYWFFYDVGSINASAHGVHVHTALKLSKDRVGRLKISNITCNASIARMQAGFSGTLRKVYEFLGLFLTTGMRFVLNQQICPALNHAGLVLLNSLLDTVPVRNPVDEHVGIDYSLLSDPVVTWDTLDMDFKGMFFYQEAENQTLVNKGERPVITETERMVYVAFSEYFFDSAMFSYFQAGVLTMEFQGDQVPKDLEVLLRATFFGSILMMSPAVVDAPLRMVLQVVTPPRCTIRPTGTAVSVNAVLNISLVPAGQPAVQLSSMSMEARLSAKVMLRQKALQVQLDLRRFRIYSKQSALESLALFSLQTPLKTLLQLTVMPIINERTRKGVQIPLPEGMDFTKEVVTNHLGYITVGADLHFSKGLREVIEKYRPAQPSTPSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0W9</accession>
    <name>A0A151P0W9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Free fatty acid receptor 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">G-protein coupled receptor 120</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Omega-3 fatty acid receptor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">FFAR4</name>
        <name evidence="26" type="ORF">Y1Q_0022169</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="20">Interacts (via C-terminus) with ARRB2 following LCFAs stimulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0W9"/>
    <dbReference type="STRING" id="8496.A0A151P0W9"/>
    <dbReference type="GeneID" id="102577256"/>
    <dbReference type="KEGG" id="amj:102577256"/>
    <dbReference type="CTD" id="338557"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9880339at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000170">
        <property type="entry name" value="Free fatty acid receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF37">
        <property type="entry name" value="FREE FATTY ACID RECEPTOR 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="25">
        <location>
            <begin position="42"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00062580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00078739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO42305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="353" mass="39509" checksum="B8CEA06199C73DFA" modified="2016-06-08" version="1">MPEAGNGTRFPFFSEVKGEAHVALSALESAVLGGVFVAALLGNARAIALLVRRRRRRRSLRAASGLVLNLFCADLLFISAIPAVLAVRWTEAWLLGDAVCHLLFYVMSLSGSVTILSLAAVSLERVVCIVRLRRSSWGRGRLLPAALLLIWGAAAIATLPLCLFFTVVRQPVGGKEIQVCTLVWPSVAGEISWDITFSIIIFVIPGLIIVISYSKILQITKASRRRLNAGLAYSEHHQIQVSQQDYKLFRTLFVLMISFFIMWSPIIITILLILVQNFKQDLNILPTFFFWIMVFTFANSAVNPILYNVTHFRHEWYRVFFCCATSSERTAAGTDTIVRRHDHEQPNVCVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1K1</accession>
    <name>A0A151P1K1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001285">
        <property type="protein sequence ID" value="KYO42967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1K1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="100" mass="10855" checksum="E1B670E9B32D8EAF" modified="2016-06-08" version="1">MWTKEVGSRDWSLAGLSGARIQIRLMDSKYQAQGRGDTSVDEPGGASSGPSSEVDNVQVNHVAISLNLTVLMQEEENSAEEKAIPEVSYLLMEMSKGQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1S5</accession>
    <name>A0A151P1S5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Fucosyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FUT4</name>
        <name evidence="21" type="ORF">Y1Q_0012920</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes alpha(1-&gt;3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1-&gt;4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1-&gt;4)-[alpha-L-fucosyl-(1-&gt;3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14257"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:137941"/>
            <dbReference type="EC" id="2.4.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:14258"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56076"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:136545"/>
            <dbReference type="ChEBI" id="CHEBI:139509"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:56077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68044"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:145343"/>
            <dbReference type="ChEBI" id="CHEBI:176900"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:68045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc6S derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:145344"/>
            <dbReference type="ChEBI" id="CHEBI:145345"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:62005"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Golgi apparatus</location>
            <location evidence="18">Golgi stack membrane</location>
            <topology evidence="18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03001255">
        <property type="protein sequence ID" value="KYO43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1S5"/>
    <dbReference type="STRING" id="8496.A0A151P1S5"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151P1S5"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017083">
        <property type="term" value="F:4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000001">
        <property type="entry name" value="alpha-(1,3)-fucosyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF132">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="19">
        <location>
            <begin position="52"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="230" mass="26652" checksum="D6E40616227921C2" modified="2016-06-08" version="1">MNFESPSNSPGLRGWGGLFNWTMSYRLDSDVFVPYGALRAARAQGPGRLVPPRKTKLVAWVISHWNEEHARVRYYRQLQKYLPVDVYGAQGLALKEGGVVGTVSEYKFYLAFENSQHTDYITEKLWRNAFEAGAVPVVLGPRRANYELFVPPDSFIHVDDFSSPRKLAVYLKFLDRNPQSYRRYFAWREKYDVHIASFWDEHYCRVCEALQAAGDHQVKTVQNLASWFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2H8</accession>
    <name>A0A151P2H8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2H8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO43276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="134" mass="14773" checksum="9238D08DC86F5074" modified="2016-06-08" version="1">MGSIEACIELYGGKEAVTLRLLLGPLAGQPAGNLLSELPLLQALMDSTTANPDGADPRSSACPVEHLEPDRCQPGPWREFRVPPPRTPEERAMFSFLLNNTQLTKQQLRILGDEDQRLLGSAMGFKYQDKPKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2W1</accession>
    <name>A0A151P2W1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0023665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001241">
        <property type="protein sequence ID" value="KYO43075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2W1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586612" evidence="2">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO43075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="205" mass="21429" checksum="E6C8BDD4AC3CC3A5" modified="2016-06-08" version="1">MGPRPEGSRGIMIIAVYLVLGAVTLASTAPTPNLCQHQDQPPGIPAWYCIVPEGGATRVPLDTPSCIVIVHAWLVGTSYPKNVLVWRPEGSVAHGLSNFTLRDGAFTVQGMVKQLCGHYEIRCSLDNSLLANITLVLPEPTSLPPTVHGSGSPHSIIPGDQGAGSFPPWSIVLIGLGILVAVAVAGYLLCRCEHLSAGAIGSRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3F0</accession>
    <name>A0A151P3F0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Estrogen-related receptor gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ESRRG</name>
        <name evidence="16" type="ORF">Y1Q_0013615</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the nuclear hormone receptor family. NR3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3F0"/>
    <dbReference type="STRING" id="8496.A0A151P3F0"/>
    <dbReference type="eggNOG" id="KOG3575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5799427at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048384">
        <property type="term" value="P:retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07170">
        <property type="entry name" value="NR_DBD_ERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06946">
        <property type="entry name" value="NR_LBD_ERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000009">
        <property type="entry name" value="estrogen-related receptor gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000008">
        <property type="entry name" value="estrogen-related receptor gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024178">
        <property type="entry name" value="Est_rcpt/est-rel_rcp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027289">
        <property type="entry name" value="Oest-rel_rcp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003078">
        <property type="entry name" value="Retinoic_acid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002527">
        <property type="entry name" value="ER-like_NR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500939">
        <property type="entry name" value="ERR1-2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01292">
        <property type="entry name" value="RETNOICACIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="119"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="227"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="452" mass="50352" checksum="5FA62F5350868580" modified="2016-06-08" version="1">MIPGGDSAHLKIRLVCRMSSKDRHIDSNCSSYIKTEPSSPASLTDSVNHHSPGGCSDASGSYSSTMNGHQNGLDSPSLYPSATGLGGNGPGRKLYEDCSSTIAEDSQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPFLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLPFEDELVYAEDYIMDEVQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3Y8</accession>
    <name>A0A151P3Y8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PPP1CA</name>
        <name evidence="16" type="ORF">Y1Q_0013524</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3Y8"/>
    <dbReference type="STRING" id="8496.A0A151P3Y8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF472">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO43465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="347" mass="39328" checksum="00B59072477B6F22" modified="2016-06-08" version="1">MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTETASTSDQFLVQNGTAPSLRDLPDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4I0</accession>
    <name>A0A151P4I0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001049">
        <property type="protein sequence ID" value="KYO43923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4I0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8852" checksum="D276673C9F0F93AA" modified="2016-06-08" version="1">MVVLQKKFGKVCCISLCCWQVYFKFSYFGVSLHREWSRAMQKVCNIPLEGGQAGSQLFNGRYYEDGQLPTWIHLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7T5</accession>
    <name>A0A151P7T5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Transcriptional coactivator YAP1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">YAP1</name>
        <name evidence="17" type="ORF">Y1Q_0023027</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the YAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000640">
        <property type="protein sequence ID" value="KYO44969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7T5"/>
    <dbReference type="STRING" id="8496.A0A151P7T5"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151P7T5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000019">
        <property type="entry name" value="Putative transcriptional coactivator YAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000012">
        <property type="entry name" value="transcriptional coactivator YAP1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053819">
        <property type="entry name" value="TEADIR3_omega_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF9">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15238">
        <property type="entry name" value="TEADIR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="281"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO44969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="432" mass="47220" checksum="12DCECA4F456ADFD" modified="2016-06-08" version="1">MNPKGANVPHTLPMRLRKLPDSFFKPPEPKAHSRQASTDAGSAGALTPQHVRAHSSPASLQLGAVSPGTLTPSGVVTGPGPASSSQHLRQSSFEIPDDVPLPPGWEMAKTPSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQPNIMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNPRITQSAPVKQPPSLAPQSPQGGVMGSGNSNQQQQMRLQQLQMEKERLRLKHQELLRQALRNINPSTANSPKHQELALRSQLPTMEQDSGSQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDSISQSNIPSHQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P912</accession>
    <name>A0A151P912_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0021280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P912"/>
    <dbReference type="STRING" id="8496.A0A151P912"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001230">
        <property type="entry name" value="Immunoglobulin kappa variable 8-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586805" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO45581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="15320" checksum="334E3D9A17FD5EC0" modified="2016-06-08" version="1">MVSLPPLLCLVVLWVQGSSGQIVLTQTPESLAVSPGDRVTIKCKASSSLTYSVFGSSYELLAWYQQKPGQAPKLLIYLGSTRQSGVPARFSGSGSGTDFTLTISSVEAEDAGDYYCQQDKSSPHTVIQTHTKTCPAAQPSTTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBC1</accession>
    <name>A0A151PBC1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Asporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ASPN</name>
        <name evidence="13" type="ORF">Y1Q_0006959</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000504">
        <property type="protein sequence ID" value="KYO46406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBC1"/>
    <dbReference type="STRING" id="8496.A0A151PBC1"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016352">
        <property type="entry name" value="SLRP_I_decor/aspor/byglycan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF2">
        <property type="entry name" value="ASPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002490">
        <property type="entry name" value="SLRP_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRNT" evidence="12">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="33"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR002490-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO46406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="338" mass="38372" checksum="BF8209557331AF07" modified="2016-06-08" version="1">MEDADDDDDDDNSLFPTREPILPLIPFDIFPVCPFGCQCYMRVVHCSDLGLTSIPSNIPPDTRMIDLQNNKIKEVKENDLKGLTSLYALALNNNKISKIHPKAFQPTKKLRRLYLSHNQLTEIPDNLPKSLAELRIHANKVKKIHKEAFKGMKSLHVLEMSANPLDNAGIEPGAFEGVTIYHIRIAEAKLTSVPKELPSSLLELHLDDNKISMIELEDFIRYKDLQRLGLGNNKIKDVENGSLANIPSLREIHLERNKLKKVPPGLPYLKYLQVVFLHNNNIPKVGINDFCPTERSMKKALYSGISLFNNPMKYWEVQPSTFRCILSANSVQLGNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBX4</accession>
    <name>A0A151PBX4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDB1- and CUL4-associated factor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">WD repeat-containing protein An11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DCAF7</name>
        <name evidence="15" type="ORF">Y1Q_0018331</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat DCAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006271632.1">
        <property type="nucleotide sequence ID" value="XM_006271570.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBX4"/>
    <dbReference type="SMR" id="A0A151PBX4"/>
    <dbReference type="STRING" id="8496.A0A151PBX4"/>
    <dbReference type="GeneID" id="102573052"/>
    <dbReference type="KEGG" id="amj:102573052"/>
    <dbReference type="CTD" id="10238"/>
    <dbReference type="eggNOG" id="KOG0290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PBX4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000049">
        <property type="entry name" value="DDB1-and CUL4-associated factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO46538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="342" mass="38926" checksum="794CC69A45D0CC7C" modified="2016-06-08" version="1">MSLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYNNKVQLVGLDEESSEFICRNTFDHPYPTTKLMWIPDTKGVYPDLLATSGDYLRVWRVGETETRLECLLNNNKNSDFCAPLTSFDWNEVDPYLLGTSSIDTTCTIWGLETGQVLGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYNNCLEILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDU3</accession>
    <name>A0A151PDU3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 451</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZNF451</name>
        <name evidence="10" type="ORF">Y1Q_0014029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000483">
        <property type="protein sequence ID" value="KYO47119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDU3"/>
    <dbReference type="STRING" id="8496.A0A151PDU3"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18721">
        <property type="entry name" value="PIN_ZNF451-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041192">
        <property type="entry name" value="PIN_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058949">
        <property type="entry name" value="Zf-C2H2_ZNF451_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058947">
        <property type="entry name" value="Zf-C2H2_ZNF451_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058950">
        <property type="entry name" value="Zf-C2H2_ZNF451_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058948">
        <property type="entry name" value="Zf-C2H2_ZNF451_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18479">
        <property type="entry name" value="PIN_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23101">
        <property type="entry name" value="Zf-C2H2_ZNF451_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23102">
        <property type="entry name" value="Zf-C2H2_ZNF451_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23103">
        <property type="entry name" value="Zf-C2H2_ZNF451_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23104">
        <property type="entry name" value="Zf-C2H2_ZNF451_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO47119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="741" mass="84214" checksum="2DE5ED976AB53060" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDU8</accession>
    <name>A0A151PDU8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muscular LMNA-interacting protein isoform D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MLIP-1</name>
        <name evidence="2" type="ORF">Y1Q_0014044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000483">
        <property type="protein sequence ID" value="KYO47150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDU8"/>
    <dbReference type="STRING" id="8496.A0A151PDU8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029331">
        <property type="entry name" value="MLIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31514:SF1">
        <property type="entry name" value="MUSCULAR LMNA-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31514">
        <property type="entry name" value="MUSCULAR LMNA-INTERACTING PROTEIN MLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15274">
        <property type="entry name" value="MLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO47150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="544" mass="61373" checksum="C16CE9623FD8B33A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFF9</accession>
    <name>A0A151PFF9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cullin-associated NEDD8-dissociated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CAND1</name>
        <name evidence="9" type="ORF">Y1Q_0019807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275407.1">
        <property type="nucleotide sequence ID" value="XM_006275345.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFF9"/>
    <dbReference type="STRING" id="8496.A0A151PFF9"/>
    <dbReference type="GeneID" id="102557749"/>
    <dbReference type="KEGG" id="amj:102557749"/>
    <dbReference type="CTD" id="55832"/>
    <dbReference type="eggNOG" id="KOG1824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PFF9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000047">
        <property type="entry name" value="Cullin-associated NEDD8-dissociated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="8">
        <location>
            <begin position="1040"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO47729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1230" mass="136319" checksum="1A66501851919F66" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGD3</accession>
    <name>A0A151PGD3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine zipper protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LUZP1</name>
        <name evidence="4" type="ORF">Y1Q_0001896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGD3"/>
    <dbReference type="GeneID" id="102559252"/>
    <dbReference type="KEGG" id="amj:102559252"/>
    <dbReference type="CTD" id="7798"/>
    <dbReference type="eggNOG" id="ENOG502QV81">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9946011at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021503">
        <property type="term" value="P:neural fold bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050719">
        <property type="entry name" value="Cortactin-Actin_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166">
        <property type="entry name" value="FILAMIN/GPBP-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166:SF7">
        <property type="entry name" value="LEUCINE ZIPPER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="693"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="921"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO48079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1125" mass="126858" checksum="FCAF8D0E1BD2CE33" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGG0</accession>
    <name>A0A151PGG0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CUB and sushi domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0001859</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CSMD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000011">
        <property type="entry name" value="CUB and sushi domain-containing protein 3 isoform A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000001">
        <property type="entry name" value="CUB and sushi domain-containing protein 3 isoform X1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000002">
        <property type="entry name" value="CUB and Sushi multiple domains 3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF6">
        <property type="entry name" value="CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="28"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0768">Sushi</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3448"/>
            <end position="3469"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="100"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="262"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="326"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="440"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="499"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="610"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="673"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="786"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="845"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="958"/>
            <end position="1017"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
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    <evidence type="ECO:0000256" key="12">
        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="3543" mass="385922" checksum="CC49D7AA59EFEBC0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIT2</accession>
    <name>A0A151PIT2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylacetamide deacetylase-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0001142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="403" mass="45568" checksum="6B22FE0E616B49DF" modified="2016-06-08" version="1">MGFIRDIFFYPIKFLLAFILHYEHPKAEIPQGLEQRIKVFLLHHFLNFGLGLAKVLDKAGLCYEHDVLRFLVDGIPPQKTNKLLIKNVMFNNLTVRIYQPKVPSAGLRRGIVYCHGGVGRFGSINAYERVCRYICRNSDSVVASVEYRLAPEHPFPAQFDDCLAATIHFMRTAEDYGVDPSRVIVCGDSSGGTIAATVCQALVDRTDLPKVRGQILIYPFLQAADFNLPSYQQNEDAPVLLKSRTLDFGFKYLNLDLSLIDDLLRGAHIPESLRQKYSKWLSPDNLPKEFKTRGYKSPQLAPCKEEVYALAQSFIGATFSPLLAEDAIIRQLPDSFILTCEYDVLRDDGLLYKKRLEDNGVRVTWCHLSDGFHGVLFAVDYGILSFKAGCRGIDRTVNFIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ95</accession>
    <name>A0A151PJ95_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000111">
        <property type="protein sequence ID" value="KYO49100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ95"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO49100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="152" mass="17536" checksum="455D15B550220E75" modified="2016-06-08" version="1">MGGVAAVSLLHSWIERRCALASGKQLEGLPFLMQTHPDLPPGYAEPFPLLIFLQLFQYLLQPLGPDHGSNQGLSRELKAEWLCTWSMDRTHPPSNSWFLLDISETAFGLSKYQERLLHFLMQCYRYGSSSQRSQQRSSRARDSRQKLRKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LY62</accession>
    <name>A0A151LY62_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Calsenilin isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KCNIP3-1</name>
        <name evidence="15" type="ORF">Y1Q_0007674</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007073">
        <property type="protein sequence ID" value="KYO17191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LY62"/>
    <dbReference type="STRING" id="8496.A0A151LY62"/>
    <dbReference type="GeneID" id="102573384"/>
    <dbReference type="CTD" id="30818"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="PhylomeDB" id="A0A151LY62"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000043">
        <property type="entry name" value="Kv channel-interacting protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF165">
        <property type="entry name" value="CALSENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO17191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="256" mass="29605" checksum="6B0937F1D3EE4DCF" modified="2016-06-08" version="1">MFEDADETKETDGSLLGDSRQTPPGKKENMKWQKPRLTRKALMKCCLVKWILSSAAPQGSDSSDSDFELEAVRHQPEGLDQLQALTKFTKKELQSLYRGFKNECPSGLVNEETFKLIYAQFFPQGDATMYAHFLFNAFDMDQSGAIRFEDFVVGLSILLRGTVHEKLNWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRYTHPILREDAPIEHVEKFFQKMDRNRDGVVTIEEFLETCQKDENIMSSMQLFENVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0H6</accession>
    <name>A0A151M0H6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0H6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="10161" checksum="DDC1606B8F2B2B58" modified="2016-06-08" version="1">MLRRTPSLWATKVSLKRSTEMEDSENWKLRGAINYPSKLLQLPVNSEADPIYSGIPSSNWKTQRLETALGRDISQHKHHGHHLSRQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0T6</accession>
    <name>A0A151M0T6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Thrombospondin type-1 domain-containing protein 7A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">THSD7B</name>
        <name evidence="20" type="ORF">Y1Q_0011670</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M0T6"/>
    <dbReference type="eggNOG" id="KOG3538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000014">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000017">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000018">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000020">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000027">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000050">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000015">
        <property type="entry name" value="Thrombospondin, type I, domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056991">
        <property type="entry name" value="TSP1_TSH7A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF7">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23308">
        <property type="entry name" value="TSP1_TSH7A-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584649" description="Thrombospondin type-1 domain-containing protein 7A" evidence="17">
        <location>
            <begin position="21"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1379"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="157"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="423"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="559"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="823"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="1071"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="18">
        <location>
            <begin position="1194"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Thrombospondin type-1" evidence="19">
        <location>
            <begin position="1298"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1407"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO18076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1429" mass="160219" checksum="3BF84024A71737AE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1E1</accession>
    <name>A0A151M1E1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006838">
        <property type="protein sequence ID" value="KYO18276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1E1"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13745">
        <property type="entry name" value="SPRY_PRY_TRIM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035033">
        <property type="entry name" value="PRY/SPRY_TRIM39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="121"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="324" mass="36756" checksum="F6CB598FD630F6C6" modified="2016-06-08" version="1">MGGPQLWRYSCQQFLLQRQSDLGRQLVVSECEGLRKLLDEHQCLLLARLGELDAEIVRRREENAARLLEETARLSTLIMELEGKCQRWPELVQGVQSTVSRGKEGTPLHPAPKFPELEKRIQDFCEENKLQEAVIAFLVDVTLDPNTAHPNLVLSQDRKRVRHRDTPQDLPDTPERFDRRFRVLGCEGFTSGRHYWEVEVGDKTAWALGVCRESVDRKGEKSLSPGNGYWALCLSGRGYEACTSPLTPLHMCVCPRRMGVFLDYGAGEVSFYNVTDRSHLFTLTHTFFEILCPFFSPGFNAEGTNAAPLILWPVPGLREAQSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M281</accession>
    <name>A0A151M281_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0017191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006790">
        <property type="protein sequence ID" value="KYO18602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M281"/>
    <dbReference type="STRING" id="8496.A0A151M281"/>
    <dbReference type="eggNOG" id="KOG2037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000422">
        <property type="entry name" value="Guanylate-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="5">
        <location>
            <begin position="118"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="5">
        <location>
            <begin position="489"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO18602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="782" mass="85564" checksum="7B3AE56133B38038" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M471</accession>
    <name>A0A151M471_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006632">
        <property type="protein sequence ID" value="KYO19296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M471"/>
    <dbReference type="eggNOG" id="ENOG502SBIG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="18673" checksum="C3173D3A3540AD43" modified="2016-06-08" version="1">MRNSTSLQKVSLSQCHETVKCAPAASSSTDYSVKYREHTHKKYRLTSERNLQIGQNVTLDSRYTRLMILESLKFYQVIFGVEDEDEPSPPKQVCREQKEHSPIYLLCEGLKDPRCKVKELGSRSCGLAAACYGDLAAVLSTSPARQSWTSVETVVGGMTVCRCCARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4Z7</accession>
    <name>A0A151M4Z7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006584">
        <property type="protein sequence ID" value="KYO19594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4Z7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000124">
        <property type="entry name" value="AGAP009560-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="154" mass="18063" checksum="867BD008F5546F0F" modified="2016-06-08" version="1">MKHLSISNWLTQLGLTEYCTLFDEQYDGVEDLLHLTEVDLRKMGIENQIHRTHIISNILLLQEAERKRALSSSKCSEWRDKARYHLTMTKSPGAGRCLPDLTPRLSNIPENFHGRNSQWVATSPVMNEDSEEESRVKYLQLFNFFLHFVYILYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M580</accession>
    <name>A0A151M580_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDC42 small effector protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CDC42SE1</name>
        <name evidence="12" type="ORF">Y1Q_0012322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006582">
        <property type="protein sequence ID" value="KYO19658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M580"/>
    <dbReference type="STRING" id="8496.A0A151M580"/>
    <dbReference type="eggNOG" id="ENOG502S499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000015">
        <property type="entry name" value="CDC42 small effector protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF3">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="11">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO19658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="8740" checksum="92ECDF0795C544F3" modified="2016-06-08" version="1">MSDFWHKLGCCVVDKPQPKKKRRRIDRSMIGEPMNFMHLTHIGSGDMAAHEGLPMTGALCPPVPCATSPRLMGGDPNPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6D9</accession>
    <name>A0A151M6D9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6D9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="115" mass="11965" checksum="4F5685BD76F1B379" modified="2016-06-08" version="1">MQVADSQPAVGVVATRLCLQGLVTLPALGAERPASASASSSANCCELLLIPAFGPGLELVTPKRGKLLPCQGLALLVIFCRDGISGAEQKNPTLNNRKSSGFSYFTVLPPVFSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6N4</accession>
    <name>A0A151M6N4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biorientation of chromosomes in cell division protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BOD1</name>
        <name evidence="5" type="ORF">Y1Q_0010757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BOD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6N4"/>
    <dbReference type="STRING" id="8496.A0A151M6N4"/>
    <dbReference type="eggNOG" id="ENOG502S57W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043244">
        <property type="entry name" value="BOD1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47391">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47391:SF1">
        <property type="entry name" value="BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="4">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO20192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="163" mass="18400" checksum="4B19C0E418289C58" modified="2016-06-08" version="1">MALLLLCPQDSRERQLIALIVEQLKSRGLFDGFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPAMNKNQLRNGLRQSVIQSGMLEAGVDRIISQSQRIRILLLHPKMRPKSVPGLLSASEEELSSDLMEVSVKLMGIQSPEDCREKQGVSAGEESEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6V7</accession>
    <name>A0A151M6V7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6V7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="153" mass="17338" checksum="DC30A2CA1338CE5E" modified="2016-06-08" version="1">MLCILNESTFHATGRIFATPLCVEDLECAPKTIETIIRELSNTTKCLEIVQNSMTDLKDCPRLKIGTKAICTNVKTNFTFFKSQFITFLKFIQTYALCNKTQDYDRNGFPADHCHCGAQEILKNYGSARKESHLQLGNWGEKGEGKKNTKTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6X2</accession>
    <name>A0A151M6X2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI domain-containing protein 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PRELID2</name>
        <name evidence="2" type="ORF">Y1Q_0010777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6X2"/>
    <dbReference type="eggNOG" id="ENOG502RYVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="181" mass="21043" checksum="A4CAF5BC5EFB7583" modified="2016-06-08" version="1">MGVTVDVRQVYKYPFEQVVASYLRKYPSPMEKHVTAVKTVEEKNDLSTGIVYRRRIATCQNVIPEILRKVSVLQVSEIYLEEESWLNAQERTMVLKTHCLTWTKFASLSEESVFRKSLENPNCTVWIRPITTRNAGLRYPRKLDDRVHTEGQNIHYRGWVAQLRIGSFCSSISQSRCEEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7S8</accession>
    <name>A0A151M7S8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7S8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="143" mass="15655" checksum="4BFCEAC2FADD97CA" modified="2016-06-08" version="1">MGRTSTSGKKTREKLLMVWSAFHWVPSVASSQVFPFSCCGVQFLIVPCPVPSQPKPAAADKLRHSCPPHILLTSSCPVLFTHAAFVYIFIRVSLSSIWVSLPLSLLRLVAKEPSSQHPEKCRTGKPRGPIPGHRGRTGRLSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8C4</accession>
    <name>A0A151M8C4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8C4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="174" mass="18633" checksum="E4570FDE63388DE5" modified="2016-06-08" version="1">MGNQHLSHWSETLVGLVNHASKILLWLSSARKGPSWNSKPSIFPAHPEVCSACNGPPRTCGLPRQAAAVAVMDRIVNVLGDCSGNESPSMKKTKSESDRARAVKPCCATTSNVMIKGFLLLIFMHEKHTAAGLIPELHQSLQAASTSGYVRVADKLEDQCLVPPAVPAGIEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8C5</accession>
    <name>A0A151M8C5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ras and EF-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RASEF</name>
        <name evidence="15" type="ORF">Y1Q_0012611</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds predominantly GDP, and also GTP. Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with the dynein-dynactin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8C5"/>
    <dbReference type="STRING" id="8496.A0A151M8C5"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1490:FF:000019">
        <property type="entry name" value="RAS and EF-hand domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001348">
        <property type="entry name" value="Ras and EF-hand domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="181"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO20741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="719" mass="81655" checksum="B51BE2CD4F0B96BC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBX2</accession>
    <name>A0A151MBX2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="15">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CYB5R2</name>
        <name evidence="18" type="ORF">Y1Q_0000631</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBX2"/>
    <dbReference type="STRING" id="8496.A0A151MBX2"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000005">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF108">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO21992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="299" mass="33311" checksum="633E44443BB88665" modified="2016-06-08" version="1">MPVAEVSVLVAAVVVGASVLLLVFKAARTRAPIALRDPNAKYPLALVEKEEISHDTRRFRFRLPSPDHVLGLPIGQHVYLSAKINGSLVIRAYTPVSSDEIKGYVDLIIKVYYKNVNPKFPEGGKMSQYLNSMNIGDTIDFRGPNGLLVYKGPGKFAIKPDKKSEAQIKFAKHLGMIAGGTGITPMLQLIRHITKDPKDDTKCYLLFANQTEKDILLRTELEEVAKKHPSQFKLWYTLDRPPQDWKYSSGFITADMIKAHPPPGNDSIILMCGPPPMIQFACQPSLDKLGYSKNNIFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC18</accession>
    <name>A0A151MC18_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A-kinase-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AKIP1</name>
        <name evidence="2" type="ORF">Y1Q_0000675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059578647.1">
        <property type="nucleotide sequence ID" value="XM_059722664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MC18"/>
    <dbReference type="STRING" id="8496.A0A151MC18"/>
    <dbReference type="GeneID" id="102573249"/>
    <dbReference type="CTD" id="56672"/>
    <dbReference type="PhylomeDB" id="A0A151MC18"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901222">
        <property type="term" value="P:regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033214">
        <property type="entry name" value="AKIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14330">
        <property type="entry name" value="A-KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14330:SF2">
        <property type="entry name" value="A-KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="154" mass="17360" checksum="10DF390C4048365F" modified="2016-06-08" version="1">MLRTAGLAREVLDRARRRRVNWPQPREEDSESLSAAFASVVEFMNQTTKECEKYYSSVPACRCRENEIKHVCRYHNRQAAENLLKALEKEKNKTSPVSSPAATPQQHGREASKDIYIEVAPGTYSVTATSEDMVKQTHVVDITAGQSIDLTFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC21</accession>
    <name>A0A151MC21_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Reticulocalbin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RCN1</name>
        <name evidence="10" type="ORF">Y1Q_0000612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CREC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006272221.1">
        <property type="nucleotide sequence ID" value="XM_006272159.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MC21"/>
    <dbReference type="STRING" id="8496.A0A151MC21"/>
    <dbReference type="GeneID" id="102561108"/>
    <dbReference type="KEGG" id="amj:102561108"/>
    <dbReference type="CTD" id="5954"/>
    <dbReference type="eggNOG" id="KOG4223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MC21"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16229">
        <property type="entry name" value="EFh_CREC_RCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000109">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000110">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000213">
        <property type="entry name" value="Reticulocalbin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027241">
        <property type="entry name" value="Rcn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF17">
        <property type="entry name" value="RETICULOCALBIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584992" evidence="8">
        <location>
            <begin position="24"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO21960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="325" mass="38204" checksum="F8CDF070D2A6DD0C" modified="2016-06-08" version="1">MGGRPGGALVLVLVLVCAGGARGKPTFRKDRVVHPEPELGERPREDNQSFQYDHEAFLGKEEARTFDQLTPEESKEKLGKIVDRIDDDKDGYVTTEELKNWIKRVQKRYIYENVAKVWKDYDLNKDNKISWEEYKQATYGYYLENPEEFQDATDQHNFKKMLPRDERRFRTADLDGDSAATREEFTAFLHPEEFEHMKDIVVLETLQDIDKNEDGFVDQDEYIADMFANEEGGPEPDWVVTEREQFSDFRDLNKDGKMDKEEIRHWILPQDYDHAQAEARHLVYESDVDKDQKLTKEEILDNWNMFVGSQATNYGEDLTKNHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCG2</accession>
    <name>A0A151MCG2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PPP2R1A</name>
        <name evidence="6" type="ORF">Y1Q_0024398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006265">
        <property type="protein sequence ID" value="KYO22203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCG2"/>
    <dbReference type="STRING" id="8496.A0A151MCG2"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="310"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="342"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="349"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="431"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="470"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="548"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO22203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="643" mass="71038" checksum="075AC30AF59C10CE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF31</accession>
    <name>A0A151MF31_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ficolin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0005582</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF31"/>
    <dbReference type="STRING" id="8496.A0A151MF31"/>
    <dbReference type="eggNOG" id="KOG2579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003823">
        <property type="term" value="F:antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001867">
        <property type="term" value="P:complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF433">
        <property type="entry name" value="FICOLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0176">Collagen</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585082" evidence="14">
        <location>
            <begin position="21"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="15">
        <location>
            <begin position="115"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO23134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
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    <accession>A0A151MFL9</accession>
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        <name type="scientific">Alligator mississippiensis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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        </source>
    </evidence>
    <sequence length="2227" mass="245278" checksum="FF83EC685A2846B3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MG40</accession>
    <name>A0A151MG40_ALLMI</name>
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        <submittedName>
            <fullName evidence="13">G-protein coupled receptor 21</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="caution">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="TAAR"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="7 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="46"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO23473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="349" mass="39500" checksum="21E8D12AE859903E" modified="2016-06-08" version="1">MNASSAAGNQSGRPFCLLALGYAETVNVCLLEAIVIVFLTALIISGNVVVIFVFHCAPLLNHHTTRYFIQTMAYADLLVGVSCLVPSLSLLHYPIVPWEPLICQVFGYVVSVLKSVSMASLACISIDRYIAITKPLTYNTLVTPWRLRVCILTIWLYSCLVFLPSFQWGKPGYHGDVFQWCADFWETDPYFTLFIVLMLYAPAACIVCFTYFNIFRICQQHTKEINERRVRFSSQEGEAGEAQSCPDKRYAMVLFRITSVFYILWLPYIIYFLLESSRVYRNHVASFLTTWLAISNSFCNCVIYSLSNSVFQKGLKRLSGAVCASCARHRLTKDSFTSRGKRPSSGCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MH64</accession>
    <name>A0A151MH64_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">microtubule-severing ATPase</fullName>
            <ecNumber evidence="10">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SPAST</name>
        <name evidence="14" type="ORF">Y1Q_0015852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MH64"/>
    <dbReference type="STRING" id="8496.A0A151MH64"/>
    <dbReference type="eggNOG" id="KOG0740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd19524">
        <property type="entry name" value="RecA-like_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000036">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000006">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="243"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO23867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="485" mass="53352" checksum="7494A160325BA5EB" modified="2016-06-08" version="1">MPGAVFRSTAGQKEQAIEWYKKGIEELEKGIAVLVVGQGDQCERARRLQSKMMTNMAMAKDRLQLLEKLQAVLQISKPQMEVYNDSTNLACRNGHLQSESGAIPKKKDPLAHTSNSLPRSKTVAKTGPTGLSGHHRTPSYSAISAVSRQGTNPATSTHKVTPKNSRTNKPSTPTTAARKKKDLKIFRNVDSNLANLILNEIVDSGPTVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSSGEDRILVMGATNRPQELDDAVLRRFTKRVYVSLPNEETRLILLKNLLSKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIKLTDFTESLKKIKRSLSPQTVDAYIRWNKDFGDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHI5</accession>
    <name>A0A151MHI5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rubicon Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0004590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO23996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHI5"/>
    <dbReference type="STRING" id="8496.A0A151MHI5"/>
    <dbReference type="eggNOG" id="KOG1829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061910">
        <property type="term" value="P:autophagosome-endosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Autophagy_HostDef_Reg"/>
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        <property type="entry name" value="PROTEIN ASSOCIATED WITH UVRAG AS AUTOPHAGY ENHANCER"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="666"/>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO23996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="677" mass="76633" checksum="1518F42373AB9F87" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIG3</accession>
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        <recommendedName>
            <fullName evidence="3">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">Y1Q_0004325</name>
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        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligator</taxon>
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:Ras protein signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO24296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="225" mass="25334" checksum="9D1B7530CEF134B8" modified="2016-06-08" version="1">MDLMNGQSSNVNIAAIASEKSSSSESLSDKGSAELKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPEELASCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKATFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLVLSREQAWAALAGKFLGSWSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJ79</accession>
    <name>A0A151MJ79_ALLMI</name>
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        <recommendedName>
            <fullName evidence="4">Rootletin-like coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0023267</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MJ79"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rootletin-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF17">
        <property type="entry name" value="ROOTLETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15035">
        <property type="entry name" value="Rootletin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="186"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1485"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
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            <end position="223"/>
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    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="399"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="926"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1566"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1811"/>
            <end position="2043"/>
        </location>
    </feature>
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        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1536"/>
            <end position="1550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO24585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2071" mass="236155" checksum="E26D2D44648831B4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK02</accession>
    <name>A0A151MK02_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat and BTB domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KBTBD12</name>
        <name evidence="4" type="ORF">Y1Q_0023727</name>
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    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK02"/>
    <dbReference type="STRING" id="8496.A0A151MK02"/>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18485">
        <property type="entry name" value="BACK_KBTBD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF491">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO24847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="531" mass="60215" checksum="CBC20C17CF715FF5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKI2</accession>
    <name>A0A151MKI2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO25038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKI2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7402" checksum="B33647E4F50EB97E" modified="2016-06-08" version="1">MEVVSQVVMCIKDGKCGAAAVGVRTCPSQRSLPISLRDVSTLQRQDLLFGLKVAEEETQLKMLHWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKZ5</accession>
    <name>A0A151MKZ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005917">
        <property type="protein sequence ID" value="KYO25204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKZ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="86" mass="9577" checksum="63FC8C47B4E40FCF" modified="2016-06-08" version="1">MEDALQLAKAFTDAKRELSKAKAMRKILLKRRQPAASIPWRGKREAAVASICVCAEAQRSERSQTQHQLRKGKTQADPDTSMAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLU9</accession>
    <name>A0A151MLU9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0023966</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005753">
        <property type="protein sequence ID" value="KYO25531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLU9"/>
    <dbReference type="KEGG" id="amj:106737695"/>
    <dbReference type="OrthoDB" id="9033588at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001836">
        <property type="entry name" value="HKR1, GLI-Kruppel zinc finger family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000189">
        <property type="entry name" value="zinc finger protein 133 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002716">
        <property type="entry name" value="Zinc finger protein 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001228">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO25531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="354" mass="39475" checksum="C66075CFC32EE544" modified="2016-06-08" version="1">MGPGSPGVQGAESPRSVPIAGDKVMSKSEEEDAQQEPHGTVLGRAEEDIAQSPEQGEACGNESEPLLPNGANCSKRGSSLPARRGQGVNNLEALSLTRNLSGKRPNLCRECGKSFRWRSRLITHQRLHTGEKPYKCHDCGQSFNESSALTVHQRIHTGEKPFKCPDCGKSFTQSSNLIQHQRIHTEEKPYKCQDCEKSFNDSRHLVRHQRSHSGDKPYQCMDCGKSFSQKSDLTRHRGTHFGEKPFKCADCEKGFSQSSDLIRHQLSHSGEKPYKCPDCGKIFSQSSNLTTHQRIHTGDKPYCCLDCGKSFSQKSDLSRHTGTHLKEKPFKCSECEKSFARSSALIRHQIIHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MM55</accession>
    <name>A0A151MM55_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periaxin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0010030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005718">
        <property type="protein sequence ID" value="KYO25627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MM55"/>
    <dbReference type="STRING" id="8496.A0A151MM55"/>
    <dbReference type="KEGG" id="amj:106737491"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052082">
        <property type="entry name" value="Myelin_sheath_structural"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23348:SF16">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23348">
        <property type="entry name" value="PERIAXIN/AHNAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO25627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="656" mass="66331" checksum="E7DADF95EAD17AD3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMU1</accession>
    <name>A0A151MMU1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serrate RNA effector molecule-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SRRT</name>
        <name evidence="7" type="ORF">Y1Q_0018530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005665">
        <property type="protein sequence ID" value="KYO25871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMU1"/>
    <dbReference type="STRING" id="8496.A0A151MMU1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERRATE/Ars2 N-terminal" evidence="6">
        <location>
            <begin position="176"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="SERRATE/Ars2 C-terminal" evidence="5">
        <location>
            <begin position="535"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO25871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="751" mass="86428" checksum="8209A467EF36C010" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPG1</accession>
    <name>A0A151MPG1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Activator 1 subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Replication factor C 38 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RFC3</name>
        <name evidence="12" type="ORF">Y1Q_0010387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA. Forms an heterotetrameric complex with RFC2, RFC4 and RFC5; this complex has ATPase activity but is not stimulated by PCNA. The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17. Interacts with CNTD1; this interaction facilitates crossover formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005510">
        <property type="protein sequence ID" value="KYO26414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006265213.1">
        <property type="nucleotide sequence ID" value="XM_006265151.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPG1"/>
    <dbReference type="STRING" id="8496.A0A151MPG1"/>
    <dbReference type="GeneID" id="102567999"/>
    <dbReference type="KEGG" id="amj:102567999"/>
    <dbReference type="CTD" id="5983"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MPG1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO26414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="356" mass="40356" checksum="29454C8BC9E8C91A" modified="2016-06-08" version="1">MSLWADKYRPVALARLDFHRDQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIMCLLRELYGAGVEKLRIEHQTITAPSKKKIEISTIASNYHLEVNPSDAGNSDRVVIQELLKTVAQSQQLETSTQRDFKVVLLTEVDKLTKDAQHALRRTMEKYMATCRLILCCNSMSKIIAPIQSRCLAVRVPAPSIEDICHVLSSVCKKEGLTLPQDLARQLAEKSGRNLRKALLMCEACRVQQYPFTSDQDIPETDWEVYLRETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKGLLTELLNNCDGQLKGEVAQMAAFYEHRLQLGSKAIYHLEAFVAKFMALYKKFMEDGLEDMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSZ1</accession>
    <name>A0A151MSZ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSZ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="10362" checksum="1ED1FB9323F2C5C9" modified="2016-06-08" version="1">MMWQGTRFQSGDHRTSRQEHDWKKKETWENLLDQKEVLLMQRMPWLLKHCFEKFLLCELSGNSRISRRHFRGRNLEKDSWQLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUD3</accession>
    <name>A0A151MUD3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0023911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005033">
        <property type="protein sequence ID" value="KYO28133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUD3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00098">
        <property type="entry name" value="IgC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO28133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="233" mass="25478" checksum="4561747EE69951F0" modified="2016-06-08" version="1">MGEVSRPQLLVPGQAVTLRCLVSGFYPGQVAVTWLRKGAGEREPRPVDGSDTHSIHTPAPSRAPDGKSYSVESELHFTPSGPEDDGVEYQCRVEHETLQKTTSKSTGPLPLRVQPQLSHIHVLPDGKAPQKTLFAVRIENFYPQHIQQIQWKVDGKAWERSKPSEIIPNPDGTFTATSVWRVPSRSLTGPGLRVRVSVKHNPGDIPMERELCLGDAGQSAPTTQVAAHEPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUM8</accession>
    <name>A0A151MUM8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autism susceptibility 2 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0020465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004988">
        <property type="protein sequence ID" value="KYO28216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUM8"/>
    <dbReference type="STRING" id="8496.A0A151MUM8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023246">
        <property type="entry name" value="AUTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429:SF24">
        <property type="entry name" value="FIBROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429">
        <property type="entry name" value="FIBROSIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO28216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="164" mass="17626" checksum="2378C8F0E05755FB" modified="2016-06-08" version="1">MQKDASLKTPERLEQRLKQSGKRKRGEGSGSEDGPGRAGSSEKGRGRRPGDRALRKPGKRRRKEASRHSYLETGYICDAESDPEEQASADELDQSFTVSASKGPGPGGAVNGTREAKLSVIPKVSGLERSQERSYEADRDALLVPFLQPQPGVYTAGLDLSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUQ2</accession>
    <name>A0A151MUQ2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004973">
        <property type="protein sequence ID" value="KYO28225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUQ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7737" checksum="0F21CF70217CD27D" modified="2016-06-08" version="1">MQIWETIMGLQDNFHTVLGKEMTVLALSQVGDLQETAGSSAGLWEVKWLKLMRKGGDVKDLLGINQCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWL9</accession>
    <name>A0A151MWL9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWL9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="113" mass="12332" checksum="5B5539374BD00377" modified="2016-06-08" version="1">MLEEASGRLGASSIFIKVFGGTCKTPFYTNGTENPGAFEYSGGQTSAIHQTDKTSQTLEKLRDYSVRKCYYNNTHLPKTTSKKNTTPQIGLNAGRLCTLYGRCLLVILASVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXC0</accession>
    <name>A0A151MXC0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXC0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="77" mass="8799" checksum="74F01693DDA8E4E4" modified="2016-06-08" version="1">MERGALGQQGCWLTFELGKKRRKPGLQECTLNSRDGDSLMSKQEVQKSTTIFTIKRQGAPWDNCRQKLRHQDGFADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYI9</accession>
    <name>A0A151MYI9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0004967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004653">
        <property type="protein sequence ID" value="KYO29572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYI9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="63"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO29572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="176" mass="20148" checksum="F05A8D2AB7135825" modified="2016-06-08" version="1">MCWCLWEEKPRRNLDGTLTLTLTYTFTPARSDAGSIFSCRIHHPALEQPLQQEITLDVIGETPHYTVSPVQSPERCLLGKEVTLRCSMVGELTQGMVVTWLRIRGGDRMAIEDDEDTEESPERALMLHTSPRGWRATQHRSKNQLMAYLTFTPTVQDDRVRVSCCFQHEAKGIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYM4</accession>
    <name>A0A151MYM4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">OTU domain-containing protein 4</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">OTUD4</name>
        <name evidence="21" type="ORF">Y1Q_0016134</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with MYD88; the interaction is direct. Interacts with ALKBH3; the interaction is direct. Interacts with USP7; the interaction is direct. Interacts with USP9X; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03004567">
        <property type="protein sequence ID" value="KYO29656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYM4"/>
    <dbReference type="STRING" id="8496.A0A151MYM4"/>
    <dbReference type="eggNOG" id="KOG2605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000660">
        <property type="term" value="P:negative regulation of interleukin-1-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034122">
        <property type="term" value="P:negative regulation of toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903093">
        <property type="term" value="P:regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22794">
        <property type="entry name" value="OTU_OTUD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20448">
        <property type="entry name" value="Tudor_OTUD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000013">
        <property type="entry name" value="OTU domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF9">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="20">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="19">
        <location>
            <begin position="262"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="168"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="335"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="458"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="850"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO29656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111838" checksum="00CEA29CD663DF70" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N271</accession>
    <name>A0A151N271_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase IMAP family member 7-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0007710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004139">
        <property type="protein sequence ID" value="KYO30884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N271"/>
    <dbReference type="STRING" id="8496.A0A151N271"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040581">
        <property type="entry name" value="Thioredoxin_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF170">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18078">
        <property type="entry name" value="Thioredoxin_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="118"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="213"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="6">
        <location>
            <begin position="522"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO30884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="89047" checksum="73D65B466EC28E45" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N365</accession>
    <name>A0A151N365_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AH receptor-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aryl-hydrocarbon receptor-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AIP</name>
        <name evidence="12" type="ORF">Y1Q_0016985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004108">
        <property type="protein sequence ID" value="KYO31273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276946.2">
        <property type="nucleotide sequence ID" value="XM_006276884.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N365"/>
    <dbReference type="STRING" id="8496.A0A151N365"/>
    <dbReference type="GeneID" id="102562047"/>
    <dbReference type="KEGG" id="amj:102562047"/>
    <dbReference type="CTD" id="9049"/>
    <dbReference type="eggNOG" id="KOG0545">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5829758at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000052">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF3">
        <property type="entry name" value="AH RECEPTOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO31273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="332" mass="38000" checksum="BC621F46C627A10D" modified="2016-06-08" version="1">MADRVAQLQADGIVKRVIRQVQGPLPEFRDGTKATFHYRTLLSQGEGQDRLLDDSRTHDKPMELIIGKKFKLPVWETVLCTMREGERAEFLCDTKHVLLYPMVSKSLRNIAAGKDPLEGQRHCCGIAQMHEHHSLGYPDLDALQQTPQPLIFDIEMIKVEAPGSYRQDPWAMTDEEKLQAVPLIHEEGNELYRQGKVHEAAAKYYDAIACLKNLQMKEQPGSPDWIELDQKITPLLLNYCQCKLRSQEYYEVLDHCSSILNKYEDNVKAYFKRGKAHAAVWNAAEAQADFAKVLALDPTLEPVVAKELHSLETRLRQKDSEDKVRFRGIFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3V7</accession>
    <name>A0A151N3V7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAPK-interacting and spindle-stabilizing protein-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitogen-activated protein kinase 1-interacting protein 1-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MAPK1IP1L</name>
        <name evidence="7" type="ORF">Y1Q_0002558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MISS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004091">
        <property type="protein sequence ID" value="KYO31315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3V7"/>
    <dbReference type="STRING" id="8496.A0A151N3V7"/>
    <dbReference type="eggNOG" id="ENOG502RYAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031653">
        <property type="entry name" value="MISS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35973">
        <property type="entry name" value="MAPK-INTERACTING AND SPINDLE-STABILIZING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35973:SF1">
        <property type="entry name" value="MAPK-INTERACTING AND SPINDLE-STABILIZING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15822">
        <property type="entry name" value="MISS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO31315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="159" mass="17155" checksum="83E001FCB8FA85EA" modified="2016-06-08" version="1">MSGADDFSLADALPDQSPAKASKVSNTKPSQQPGQPPQGWPASNPWNNPSAPPAVPSGLPPNTSASNVPFGPPPTGIAVCSCWCSINAWWPPSLPLNTCWATKYLTFGVVKSTRLLYMNFELLLYPSVMHQSTNCTRMGNSNPEQRNQGEGDYTESQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N437</accession>
    <name>A0A151N437_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0006113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N437"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8129" checksum="6DD0418D05D03EDB" modified="2016-06-08" version="1">MACTIHRQYGGLERANYQKYENFPRSACSGGLLEHSLSLNLALLHLYTLAFRGRLKIKPREADLKPLGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4C8</accession>
    <name>A0A151N4C8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Unc-119-like protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UNC119B</name>
        <name evidence="8" type="ORF">Y1Q_0022782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N4C8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000001">
        <property type="entry name" value="protein unc-119 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051519">
        <property type="entry name" value="PDE6D_unc-119_myristoyl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951:SF3">
        <property type="entry name" value="PROTEIN UNC-119 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951">
        <property type="entry name" value="RETINAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="7">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO31686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="227" mass="25795" checksum="C99B837F8C172313" modified="2016-06-08" version="1">MSGSKARAAAAGPDKKPXXXXSGDAASRAGVPCTEAELLALETVRPEHVLALSRVTDHYLCKPEDNIYNIDFTRFKIRDLETGTVLFEIAKPSATEQDEEEDDDGGELDTSAGRFVRYQFTPAFLRLRTVGATVEFTVGDKPVSNFRMIERHYFRDRLLKNFDFDFGFCIPSSRNTCEHIYEFPQLSEDLIRLMVENPYETRSDSFYFVDNKLIMHNKADYAYNGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4S0</accession>
    <name>A0A151N4S0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MTFP1</name>
        <name evidence="4" type="ORF">Y1Q_0022886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449085.1">
        <property type="nucleotide sequence ID" value="XM_014593599.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4S0"/>
    <dbReference type="STRING" id="8496.A0A151N4S0"/>
    <dbReference type="GeneID" id="102567696"/>
    <dbReference type="KEGG" id="amj:102567696"/>
    <dbReference type="CTD" id="51537"/>
    <dbReference type="eggNOG" id="KOG3945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO31824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="18263" checksum="40380B2EFC16AF70" modified="2016-06-08" version="1">MGSAEAAPPAARDPLRDSWLRYLGYANEVGESFRAIVPVWLVWSTYGVATTYVTVDAIDKGKRAAVAHEHSSGKRARVAVAVVDTFIWQSLASVAIPGFTINRICAASLYLLGTMTRWPVSVRKWTTTAIGLSAIPFIVKPIDRSVDFLMDSSLRKLYSTEETPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6L4</accession>
    <name>A0A151N6L4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NME3</name>
        <name evidence="14" type="ORF">Y1Q_0020406</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:44641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18114"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263268.1">
        <property type="nucleotide sequence ID" value="XM_006263206.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6L4"/>
    <dbReference type="STRING" id="8496.A0A151N6L4"/>
    <dbReference type="GeneID" id="102565993"/>
    <dbReference type="KEGG" id="amj:102565993"/>
    <dbReference type="CTD" id="4832"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N6L4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585780" description="Nucleoside diphosphate kinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="13">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO32472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="19164" checksum="DB98EBE46C13A059" modified="2016-06-08" version="1">MICLVLALFAHVFQPGRGAERTFVAVKPDALQRRLLGDIVRRFERKGFRLVAMKLVQASEDLLSEHYFALRDRPFYNHLVKYMSSGPVVAMVWQGLDVVKTARAMIGETNPADSRPGTIRGDFCIEVGKNVIHGSDSIESARREISLWFREDELICWEDHAEHWIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N869</accession>
    <name>A0A151N869_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LPIN1</name>
        <name evidence="8" type="ORF">Y1Q_0011325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27429"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27430"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03003826">
        <property type="protein sequence ID" value="KYO33014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N869"/>
    <dbReference type="STRING" id="8496.A0A151N869"/>
    <dbReference type="eggNOG" id="KOG2116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF10">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE LPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="7">
        <location>
            <begin position="759"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO33014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="975" mass="107619" checksum="DF2E62E562A27A13" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8L4</accession>
    <name>A0A151N8L4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8L4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585834" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7922" checksum="C21FE9A0E5B65391" modified="2016-06-08" version="1">MWKAPLWGVASCFWLRAWQLWRGASPRPEGEWGESQQQHHHAKALCSAKARGRRYQSSIAGDAKTGCLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAJ8</accession>
    <name>A0A151NAJ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0024491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAJ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="7856" checksum="9BC7F855BCECCACF" modified="2016-06-08" version="1">MQHHGLSPNSLISQEKVHDHSFSVKSSSVSAAHSSTRHHLTPSGLHSTASLPKITRFLYAMLRPVLLNCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NB06</accession>
    <name>A0A151NB06_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adenosine receptor A2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADORA2B</name>
        <name evidence="13" type="ORF">Y1Q_0015328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003672">
        <property type="protein sequence ID" value="KYO33799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NB06"/>
    <dbReference type="STRING" id="8496.A0A151NB06"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001609">
        <property type="term" value="F:G protein-coupled adenosine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001634">
        <property type="entry name" value="Adenosn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF18">
        <property type="entry name" value="ADENOSINE RECEPTOR A2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00424">
        <property type="entry name" value="ADENOSINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU201114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO33799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="107" mass="11502" checksum="C04150D314E98906" modified="2016-06-08" version="1">MNSPYIALELLIALLSIAGNVLVCWAVATNRTLKTATNYFLVSLAVADIGVGALAIPFAITISIGFHADFHSCLFLACFVLVLTQSSIFSLLAVAVDRYMAIRIPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBB5</accession>
    <name>A0A151NBB5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A-kinase anchor protein 10, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AKAP10</name>
        <name evidence="3" type="ORF">Y1Q_0015312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003672">
        <property type="protein sequence ID" value="KYO33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBB5"/>
    <dbReference type="STRING" id="8496.A0A151NBB5"/>
    <dbReference type="eggNOG" id="KOG3590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12804">
        <property type="entry name" value="AKAP10_AKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08721">
        <property type="entry name" value="RGS_AKAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000019">
        <property type="entry name" value="A-kinase anchor protein 10, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000005">
        <property type="entry name" value="Putative A-kinase anchor protein 10 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037719">
        <property type="entry name" value="AKAP10_AKB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="203"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="487" mass="54301" checksum="0E33090EA1FEEA56" modified="2016-06-08" version="1">MSFFRRKVKGREQEKTSDVKAIKTAIPVHSPQRNTRNHALLEAAGPSHVAINAISANMDSFSSSRTAALKKQPSHMEAAHFGDLGRSSEQEPSKLTVSNRNSPSSALKDLSGKLMKSIERDAVNTFTKYISPDAAKPIPITEAMRNDIVAKICGEDGQVDPNCFVTAQSIVFNAMEQEHFSEFLRSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDSVRLEIESNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFAGGNIALTLQGPHSTPDNDSHTGGPEGSASQSSVKKANVKILKNFDEAIIVDAASLDPETLYQRTYAGKMTFGRVSDLGQFIRESEPEPDVKKSKGSMFSQAMKKWVQGNTDEAQEEMAWRIAKMIVNDVMQQAQHDQPLEKVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDA9</accession>
    <name>A0A151NDA9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0010536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003332">
        <property type="protein sequence ID" value="KYO34797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDA9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001872">
        <property type="term" value="F:(1-&gt;3)-beta-D-glucan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071226">
        <property type="term" value="P:cellular response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042808">
        <property type="entry name" value="CLEC7A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="125"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO34797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="278" mass="31485" checksum="A1A7E1AD11951FF1" modified="2016-06-08" version="1">MTAYSELKFQNLPEQQRSTRAQQTECRGTGGSPSPRRRNKDPSATPLQRQLATLVLGILCLILLITTGVLGYNVVQLGIQRKSFHEQVGYLSSELTSCQNQGVPGSVQELPHDIGEKCPARWSHSTSRSYLFSPEKRHWDQCKYSCSSHSASLITMESREELDFIMTESLHYSEDRGSTTYYFPFWTGLVYDSVRGKWFWEDGTTLSSGMSLEGYLTSPGIGLTNPEVSVITTLRLSRSSCIAQTAGLLMKDNEDEQDFINHELFQYYEDRDSAVFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDY5</accession>
    <name>A0A151NDY5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase I subunit RPA49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">POLR1E</name>
        <name evidence="7" type="ORF">Y1Q_0000900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDY5"/>
    <dbReference type="STRING" id="8496.A0A151NDY5"/>
    <dbReference type="GeneID" id="102562586"/>
    <dbReference type="KEGG" id="amj:102562586"/>
    <dbReference type="CTD" id="64425"/>
    <dbReference type="eggNOG" id="KOG4183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NDY5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="417" mass="46864" checksum="8D2426E127D538A3" modified="2016-06-08" version="1">MAAAADAAGWSYRGGPRDEQSALLVHFSNGRLQNSEDMNFTLYKSKDTTNPRKKHRRILTSETERLSYVGNNFGTSALKCNSLCRYFVGVLDKDSGQMEVYNAELFNMQPLLSDDVIEDDLSDYQSKSYREKVDSCIEAFGSNKQKRALNSRRMNQVGNETLNMAVTRAAENIIGAKGVATLVSDAAQDDVEEVSLFLPPCHEEADKPENIYRFEDLISSAEYEALQAPAAALTNLTSEEILKKPEEESLCSFVLEELKSMPVDESSRDHKARCLWFLDTLIKFSYKKVIKKKCPMGPDCPRIINKKLMKNFTALTYNSGRIQNLISASMKAKITAYVVALALHINKFQIDLTLLQRDMKLHETRMLDIAKAMRLKISKKKGLSGLGADEDHKFGTLSLPLPSFKPSGGQRKRKKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEJ2</accession>
    <name>A0A151NEJ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0014614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03003220">
        <property type="protein sequence ID" value="KYO34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEJ2"/>
    <dbReference type="STRING" id="8496.A0A151NEJ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="110"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="4">
        <location>
            <begin position="327"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO34955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="408" mass="45680" checksum="6FE576A74CC23CEC" modified="2016-06-08" version="1">MYGDWDGEAGIEELHLPDHLPSQDKDQLLPALKDFETVFSNKPGKMDLAVHSIDTGSHRPIFSRHYPVKKKVKQEIKQEIAEMEDLGVIRPSMSPWASLVVLVRKQDGTIWFCVDYRKLNSITTPDVYPMPRMDTLLDCLGPAKVISTLDLSKGFWQMALDLDAIAKSAFTTPIGLYEFTVLPFGMRNSPASFQRLINNLLQGCKQFAMAYIVDIAIFSQDFKSHLIHLTTVLGKIKQAGLTVKDKKCQWALSEVVYLGHCVGGGEIAPLWGKIEAIKDWPPPQTKKQVRAFLGLVGYYRRFVPGFGATAAPLHELTRKGSPDPVVWKQGCQEAFDILKAALVKHPILKAPLHDKPFYVATDASDVGLGAVLLQEHQETRHPVVYLSWKLIPQERNLSSIEKECLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFG3</accession>
    <name>A0A151NFG3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFG3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="81" mass="9302" checksum="90496CC7A7D5ADCA" modified="2016-06-08" version="1">MALLLTDGHCVKGKEKSWSSGHYRKSLLSKDFLIRWEDCQLVRIAVTEQKRCYASNLDMCIQDLSCYVNSKRALKGLTLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHG1</accession>
    <name>A0A151NHG1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0019586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002979">
        <property type="protein sequence ID" value="KYO36190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHG1"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050916">
        <property type="entry name" value="SCAN-C2H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935">
        <property type="entry name" value="PROTEIN ZBED8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45935:SF15">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="5">
        <location>
            <begin position="437"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO36190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="658" mass="71626" checksum="019B9A07BB40B56D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHP1</accession>
    <name>A0A151NHP1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane protein 184B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMEM184B</name>
        <name evidence="6" type="ORF">Y1Q_0024092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259014.1">
        <property type="nucleotide sequence ID" value="XM_006258952.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019345002.1">
        <property type="nucleotide sequence ID" value="XM_019489457.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059582393.1">
        <property type="nucleotide sequence ID" value="XM_059726410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHP1"/>
    <dbReference type="STRING" id="8496.A0A151NHP1"/>
    <dbReference type="GeneID" id="102572739"/>
    <dbReference type="KEGG" id="amj:102572739"/>
    <dbReference type="CTD" id="25829"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NHP1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO36332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="410" mass="46074" checksum="4C64A2E55099464B" modified="2016-06-08" version="1">MIVVTGVMSAPELGSSATTPAAAPNFSWMPNDGSPTAVEQPIFLMTTAAQAISGFFVWTALLITCHQIYMHLRCYSCPNEQRYIVRILFIVPIYAFDSWLSLLFFTNDQYYVYFGTVRDCYEAFVIYNFLSLCYEYLGGESSIMSEIRGKSIESSCMYGTCCLWGKTYSIGFLRFCKQATLQFCVVKPLMAISTVILQVFGKYRDGDFDVTSGYLYVTIIYNISVSLALYALFLFYFATRDLLSPYSPVLKFFMVKSVIFLSFWQGMLLAILEKCGAIPKIHSANVSVGEGTVAAGYQDFIICVEMFFAALALRHAFTYKVYADKRLDAQGRCAPMKSISSSLKETMNPHDIVQDAIHNFSPAYQQYTQQSTLEHGPPWRNGGHVISRSHSVSGGRDNEKTLLLSSDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJZ7</accession>
    <name>A0A151NJZ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="11">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0008408</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the GYS1-GYG1 complex, a heterooctamer composed of a tetramer of GYS1 and 2 dimers of GYG1, where each GYS1 protomer binds to one GYG1 subunit (via GYG1 C-terminus); the GYS1 tetramer may dissociate from GYG1 dimers to continue glycogen polymerization on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJZ7"/>
    <dbReference type="STRING" id="8496.A0A151NJZ7"/>
    <dbReference type="eggNOG" id="KOG3742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000028">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF2">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE, MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="7 11" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="655"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO37126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="759" mass="86572" checksum="2361FF5DB4FCC157" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLH0</accession>
    <name>A0A151NLH0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho guanine nucleotide exchange factor 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0004751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in developmental myelination of peripheral nerves.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002623">
        <property type="protein sequence ID" value="KYO37643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NLH0"/>
    <dbReference type="KEGG" id="amj:102574027"/>
    <dbReference type="eggNOG" id="KOG3522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28697at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000340">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF14">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="406"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1261"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="576"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1227"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1263"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO37643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1355" mass="151758" checksum="6B7E895E30F41C80" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLJ9</accession>
    <name>A0A151NLJ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Required for meiotic nuclear division 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RMND1</name>
        <name evidence="4" type="ORF">Y1Q_0021993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002600">
        <property type="protein sequence ID" value="KYO37691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLJ9"/>
    <dbReference type="STRING" id="8496.A0A151NLJ9"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="152"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO37691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="375" mass="43158" checksum="CA1DA3E806E463B0" modified="2016-06-08" version="1">MSRGNVTTSVKTLNHQTREVLPPFGERFGSVTPINDNPLGWSAKKLLKIPKRCYPVVSTGQTIPKQNIVPSKRPPKAPRTKQPSRSTKPLFSETEDQMQCIAYATADEYHLGNLSEDLSAEGYIEINLPKDAANILVIGTENSAKQYDSGMIFLFREGSVVFWNVENKTVKNIMQVLERHEIQPYETALVHWENEELNYRRGEGQSNLHNGEILLNCDLKTDEDILEKFAFSNALCLSVKLAIWESSLDMFVESIQSIPEILKSRKKVKLSHADVMQKIGELFALRHRINLSSDLLITPDFYWDRAHLEQLYDKTCQFLSIARRVKVMNEKLQHCMDLTDLMRNHLNEKHALRLEWMIVILITIEVMFELVSRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NN04</accession>
    <name>A0A151NN04_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Membrane-associated progesterone receptor component 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0015496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NN04"/>
    <dbReference type="STRING" id="8496.A0A151NN04"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF23">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO38207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10925" checksum="3A36F2C10776384F" modified="2016-06-08" version="1">MLSCAKSPGLGDGPYGIFAGRDASRGLATFCLDKEALKDEYDDLSDLDATQQETLQDWESQFTFKYPCVGKLLKEGEEPTVYSDEEETTDAKDEKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNM5</accession>
    <name>A0A151NNM5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNM5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11758" checksum="B1FA8A8DBBF0ECB9" modified="2016-06-08" version="1">MAISSFKSFIRASTELYCGILPSLQIWVPQNSKNRVVGVNKSTGSISTRHRELKLSRPDCCEYCNTPNPFRNLVACQHTARSEICPEEAQCDWDKWQLQVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNY1</accession>
    <name>A0A151NNY1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-interacting lysosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RILP</name>
        <name evidence="4" type="ORF">Y1Q_0016901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002446">
        <property type="protein sequence ID" value="KYO38552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNY1"/>
    <dbReference type="STRING" id="8496.A0A151NNY1"/>
    <dbReference type="OrthoDB" id="10069524at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF7">
        <property type="entry name" value="RAB-INTERACTING LYSOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH2" evidence="3">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO38552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="152" mass="16761" checksum="1B39CB53DEB572E3" modified="2016-06-08" version="1">MSMNEDLRNKLAVTQAQLRAALEKNGDAETTAPPGRREQERPASTVPATDAPGPSAAGVTVPGEELQPPGRATSSADRGFSKEELQQILQERNELKTSLFLVREELAYYQREVLNQEHVPGLLLDAMKSVVKRQRKKIRAKMLGTVDEPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPI1</accession>
    <name>A0A151NPI1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium/calmodulin-dependent protein kinase type 1D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CAMK1D</name>
        <name evidence="8" type="ORF">Y1Q_0023440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPI1"/>
    <dbReference type="STRING" id="8496.A0A151NPI1"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14083">
        <property type="entry name" value="STKc_CaMKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000561">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO38747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="401" mass="44781" checksum="85147B9FA2A33CC2" modified="2016-06-08" version="1">MVYQDDSSHVATLSRPDNEELIETSKGLQCLLPLVWRVRGAFSEVVLAEERASGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVFYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISESAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRRLHLGSSLDSSNAGVSNTLSLTNPRSDGTARKDCMSPSTLCSFVSSASSGISAVGGERRPRPTTVTTVHTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPT8</accession>
    <name>A0A151NPT8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HSPA14</name>
        <name evidence="8" type="ORF">Y1Q_0023425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263647.1">
        <property type="nucleotide sequence ID" value="XM_006263585.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPT8"/>
    <dbReference type="STRING" id="8496.A0A151NPT8"/>
    <dbReference type="GeneID" id="102563013"/>
    <dbReference type="KEGG" id="amj:102563013"/>
    <dbReference type="CTD" id="51182"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NPT8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10238">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000013">
        <property type="entry name" value="Heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000433">
        <property type="entry name" value="Heat shock protein family A (Hsp70) member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042049">
        <property type="entry name" value="HSPA14_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO38730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="506" mass="54371" checksum="324A45BB3612F593" modified="2016-06-08" version="1">MAAIGVHLGCTCACAAVYKDGRADVVANDAGDRVTPAVVAYSESEEVVGLAAKQSRVRNISNTVVKVKQILGRSSGDPQAEKYITESKCSVTEKNGKLQYEMDNKLVSPEEVAKLIFSKMKETAQSALGSDVNDVVITVPFDFGENQKNALGEAAGAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNVLVYKLGGTSLSITVIEVNSGIYRVLATNTDDSIGGVCFTEALAQHLASEFQRGYKHDIRENPRAMMKLMNSADIAKHSLSTLGSANCFVDSLYDGLDFDCNVSRARFELICSPLFNKCIEAIKKLLQQVRLTADDINKVVLCGGSARIPKLQHLIKDLFPTVELLNSIPPDEVIPIGAAIEAGILLGRENLLLEDEALSMECSAKDILVKGVDESGSDTFTVLFPSGTPLPARRQHTLQAPGSNSSVCLELYESIGKCLAKEEDKFAQIVLQDLDKKEDGLHDILTVLTMKRDGSLHITCTDQDTGKCEVITVEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRE9</accession>
    <name>A0A151NRE9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">THO complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ALYREF</name>
        <name evidence="9" type="ORF">Y1Q_0006603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002308">
        <property type="protein sequence ID" value="KYO39313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRE9"/>
    <dbReference type="STRING" id="8496.A0A151NRE9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12680">
        <property type="entry name" value="RRM_THOC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000273">
        <property type="entry name" value="THO complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="66"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO39313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="216" mass="22653" checksum="27E78BEBA462DC1B" modified="2016-06-08" version="1">MAPCTAGSRAPGRGGTGSGPSSGTATTCCPPVTSAPLNHPKQLPEKWQHDLFDSGFGAGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDTQRRPIQSVNRGGMTRTRGSGFGGGGSNRRGSRGGNRGRGRGTGRSSKQQLSAEELDAQLDAYNARMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NV26</accession>
    <name>A0A151NV26_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NV26"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11845" checksum="6687151E0118A98C" modified="2016-06-08" version="1">MDLNKLHPLFDFWIANYLPLKKICPLLWKKWNGIETASVFIIVKDSKGCSDTFIHFVAENHRKRSSPSNVGSLIEITQVHSVNRARRAVKNIQVKRIICSIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVR2</accession>
    <name>A0A151NVR2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001786">
        <property type="protein sequence ID" value="KYO40992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVR2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="9093" checksum="C184EC190656325A" modified="2016-06-08" version="1">MDSSGRSRQHPGLVKPLSGAACGRGRQAEPNPDPHAPPPQSGEGRTGPGRAPFVASLTAAAARARGRVARSCRADRGIKAVIKKLAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW64</accession>
    <name>A0A151NW64_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">COX10</name>
        <name evidence="15" type="ORF">Y1Q_0013395</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AKHW03001857">
        <property type="protein sequence ID" value="KYO40829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NW64"/>
    <dbReference type="STRING" id="8496.A0A151NW64"/>
    <dbReference type="eggNOG" id="KOG1380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO40829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="495" mass="54197" checksum="A194CE43DFDAAE39" modified="2016-06-08" version="1">MVPEDPVVWCSGAEAPFAPAGSADPEAVHGGQDGGAQGLRDEGSWGRCRRPRAVNAAHCCGPARAVPGLFVWHLQKRAMQHMPCKLIRICRLASKRWITFQHFSFLKRMYVTQCNKSLYQQAKPKPDPVAPPFQERQHLGHEKTVIHKIKPVSLPCLPLPEASKGAEFSKAKLAAEIEGSATSGIEESKEEKQWKEMKLRLDDLPGILARLSKIKLTALVVSTASAGFAMAPVPFDFTCFLLASVGTGLASCAANSINQFFEVPFDSNMSRTKNRPLVRGQISPLLAVSFAASCAIPGIALLTLGVNSLTGALGAFNIFLYTCCYTPMKRMSIANTWVGAVVGAIPPIMGWTAATGSLDPGALLLGGILYSWQFPHFNALSWNLREDYSRGGYCMMSVTHPAMCKRVALRHCLALIGLSTMAPVLDVTTWTFPVISLPINLYISYLGFRFYRDADRSSSRSLFFCSLWHLPMLLLLMLTCKKSLIENDDKGKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWY2</accession>
    <name>A0A151NWY2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 182</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMEM182-1</name>
        <name evidence="12" type="ORF">Y1Q_0006216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWY2"/>
    <dbReference type="STRING" id="8496.A0A151NWY2"/>
    <dbReference type="GeneID" id="102558102"/>
    <dbReference type="KEGG" id="amj:102558102"/>
    <dbReference type="CTD" id="130827"/>
    <dbReference type="eggNOG" id="ENOG502QVS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9942154at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026763">
        <property type="entry name" value="TMEM182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32012:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32012">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 182-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO41387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="233" mass="26357" checksum="804A20AE88F2C752" modified="2016-06-08" version="1">MKLNVGIFFGGFFGALGILLFLVAFGTDYWLLATEGGKCTTGPDDVGEEKITFHHEGFFWRCWFSGDVGENTTNIWKFWYTNQPPSKNCTHAYLSPFPRIRDEYNSTSYDSAIIYRGFWTVLMLLGVVTALMAGFFIICAAPYASHILYKTGGGFFISAGIIFSLVVVMYVIWVQAMADLENYENMKKKDCPDFTVHVRYGWSFILAPIGIFFALFAGMLFLLVGRTIYLHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX97</accession>
    <name>A0A151NX97_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0006297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX97"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO41506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="210" mass="23392" checksum="BE4DB6C5766009DC" modified="2016-06-08" version="1">MQRKITDLLVVKFNNLEAFGDADETAGELREFTGIQITDSSGSTEGPLLLCDIQAISWSILVPSVKPPATSVCQTSFQATSSLRISSVHASLDPCVRFSQGTLKDTYKQHKSRTEEVQHGSQLSPVHQVPNVCLQPSLLAGMIDDDRVQMRFARCVAGTDVDLHLLTWQRVNPKKLFEGHLFDTSDNEITNRKYEKGNNLLSGDTLRNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXR3</accession>
    <name>A0A151NXR3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PPP1R32</name>
        <name evidence="4" type="synonym">PGL2</name>
        <name evidence="4" type="synonym">SDH5</name>
        <name evidence="4" type="synonym">SDHAF2</name>
        <name evidence="6" type="ORF">Y1Q_0006403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with SDHA within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXR3"/>
    <dbReference type="STRING" id="8496.A0A151NXR3"/>
    <dbReference type="eggNOG" id="ENOG502QR8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031410">
        <property type="entry name" value="SAXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34349">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34349:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15691">
        <property type="entry name" value="PPP1R32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO41657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="596" mass="67097" checksum="D7F1F39F3E7BA18E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY07</accession>
    <name>A0A151NY07_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Triokinase/FMN cyclase</fullName>
            <ecNumber evidence="5">2.7.1.28</ecNumber>
            <ecNumber evidence="4">2.7.1.29</ecNumber>
            <ecNumber evidence="6">4.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">TKFC</name>
        <name evidence="32" type="ORF">Y1Q_0006409</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>FAD = riboflavin cyclic-4',5'-phosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:76202"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.6.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="23">Homodimer. Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.28" evidence="5"/>
    <dbReference type="EC" id="2.7.1.29" evidence="4"/>
    <dbReference type="EC" id="4.6.1.15" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014448954.1">
        <property type="nucleotide sequence ID" value="XM_014593468.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY07"/>
    <dbReference type="STRING" id="8496.A0A151NY07"/>
    <dbReference type="GeneID" id="102566051"/>
    <dbReference type="KEGG" id="amj:102566051"/>
    <dbReference type="CTD" id="26007"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034012">
        <property type="term" value="F:FAD-AMP lyase (cyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000003">
        <property type="entry name" value="triokinase/FMN cyclase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011049">
        <property type="entry name" value="PRK14479.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="31">
        <location>
            <begin position="10"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="30">
        <location>
            <begin position="373"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="27">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00046681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KYO41664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="579" mass="59177" checksum="6653E562FC0813C2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY21</accession>
    <name>A0A151NY21_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Short stature homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SHOX</name>
        <name evidence="11" type="ORF">Y1Q_0006291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260925.1">
        <property type="nucleotide sequence ID" value="XM_006260863.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY21"/>
    <dbReference type="STRING" id="8496.A0A151NY21"/>
    <dbReference type="GeneID" id="102558311"/>
    <dbReference type="KEGG" id="amj:102558311"/>
    <dbReference type="CTD" id="6473"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000057">
        <property type="entry name" value="Short stature homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF2">
        <property type="entry name" value="SHORT STATURE HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="114"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="10">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO41499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="291" mass="32581" checksum="63DE52B41FDC7673" modified="2016-06-08" version="1">MEELTAFVSKSFDQKSKESSSSSGSSNKKETITYREVLESGLARSRELGNSDTNLQDITESSNHCPVHLFKEHVESDKDKLKEFSTGRTAEGIYECKEKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVILGTASHLDACRVAPYVNMGALRMPFQQVQAQLQLEGVAHAHPHLHPHLAAHAPYLMFPPPPFGLPIASLAESASAAAVVAAAAKSNSKNSSIADLRLKARKHAEALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY34</accession>
    <name>A0A151NY34_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-directed RNA polymerase III subunit L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">POLR2L-1</name>
        <name evidence="11" type="ORF">Y1Q_0006298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY34"/>
    <dbReference type="STRING" id="8496.A0A151NY34"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO41509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="11768" checksum="FE1BFD30DFEDD30A" modified="2016-06-08" version="1">MPFDQRFPAYRAHTTNGADPPSARRVAARVPPSSCRRMIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLLNYAPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYX4</accession>
    <name>A0A151NYX4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0006392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYX4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO41645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="288" mass="32891" checksum="904B66EE576229F4" modified="2016-06-08" version="1">MSQKAKASSMELMAQEADTSNARGPNWTQEELKDLINIWLEERIIDRLENRRNKPVYVEIAEGMQAQGHSCDLTQVQYKTKSLRSAFYRAKDANSHSRAGHTIAPFYDKLSVILSKGVGDNLGAEENAQLWEKVTWSSKELEDVRDSNVVACEAARAAQSHLETLEWREGKIMIACVATSLQKRVQLAQVVEPHFEKVRQCLYGMKPEIELWENHKERTDEGEEIDDYPGAKPSPYVPAWREELGQAFPVMVTRLGHKWGIPEQSCTPLAVRRFEIYRSSITPSWESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZ79</accession>
    <name>A0A151NZ79_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9 10">U1 snRNP C</shortName>
            <shortName evidence="9 10">U1-C</shortName>
            <shortName evidence="9 10">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">SNRPC</name>
        <name evidence="13" type="ORF">Y1Q_0002438</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001615">
        <property type="protein sequence ID" value="KYO41745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014453783.1">
        <property type="nucleotide sequence ID" value="XM_014598297.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZ79"/>
    <dbReference type="STRING" id="8496.A0A151NZ79"/>
    <dbReference type="GeneID" id="102565474"/>
    <dbReference type="KEGG" id="amj:102565474"/>
    <dbReference type="CTD" id="6631"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO41745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="159" mass="17410" checksum="82366A57DA92CC91" modified="2016-06-08" version="1">MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFSAPPPAGAMIPPPPSIPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPSRPMMVPTRPGMTRPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0A1</accession>
    <name>A0A151P0A1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">E3 ubiquitin-protein ligase UHRF</fullName>
            <ecNumber evidence="19">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">RING-type E3 ubiquitin transferase UHRF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin-like PHD and RING finger domain-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin-like-containing PHD and RING finger domains protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Y1Q_0000237</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="19">The YDG domain mediates the interaction with histone H3.</text>
    </comment>
    <comment type="domain">
        <text evidence="19">The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03001382">
        <property type="protein sequence ID" value="KYO42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0A1"/>
    <dbReference type="STRING" id="8496.A0A151P0A1"/>
    <dbReference type="eggNOG" id="ENOG502QRDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15616">
        <property type="entry name" value="PHD_UHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16769">
        <property type="entry name" value="RING-HC_UHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20455">
        <property type="entry name" value="Tudor_UHRF1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20457">
        <property type="entry name" value="Tudor_UHRF1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17122">
        <property type="entry name" value="Ubl_UHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.280.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000068">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000143">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1150:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000066">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021991">
        <property type="entry name" value="TTD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047406">
        <property type="entry name" value="Ubl_UHRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12148">
        <property type="entry name" value="TTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="22">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="325"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="YDG" evidence="24">
        <location>
            <begin position="429"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="719"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="628"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU369101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO42552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="805" mass="90111" checksum="42F629C9C0677387" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0H1</accession>
    <name>A0A151P0H1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activated RNA polymerase II transcriptional coactivator p15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">SUB1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SUB1L1</name>
        <name evidence="13" type="ORF">Y1Q_0000254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001382">
        <property type="protein sequence ID" value="KYO42578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0H1"/>
    <dbReference type="STRING" id="8496.A0A151P0H1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.31.10:FF:000001">
        <property type="entry name" value="Activated RNA polymerase II transcriptional coactivator p15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="12">
        <location>
            <begin position="95"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO42578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="158" mass="17663" checksum="11E2626B21CF0CBF" modified="2016-06-08" version="1">MSKLVLVMLSDHPSTQLGAVGRLLCFVAGLLRCRMSKPKELAETTSSGSDSELEKEKKRKKEMPSKPEKKPKTEANSSKAATKSHGQDSEEEGMFQIGKMRYVRVSCFKGKVLVDIREFYIDKEGDTKPGRKGISLSAEQWNQLKEVIPEIDAAVKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0S3</accession>
    <name>A0A151P0S3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC97</name>
        <name evidence="3" type="ORF">Y1Q_0011427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001425">
        <property type="protein sequence ID" value="KYO42500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0S3"/>
    <dbReference type="STRING" id="8496.A0A151P0S3"/>
    <dbReference type="KEGG" id="amj:106737109"/>
    <dbReference type="eggNOG" id="KOG3044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO42500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="263" mass="30262" checksum="0D3621016D9AC056" modified="2016-06-08" version="1">MLAAVASSPLPVCSQQRGEPELTAGEKRALLEALYRQKPGLFLERFHRALRPPHLGCFAHLAGRYDVAFYCGEVQRAARQAHARTRTRNRRYAALQQLIRDGEYFSRGAMRARAPLLYQQYVGRYLSEAERRQELAQDRAREREQAGGCLLAGALLDCYQEQELLRAQQEQEEACREEEDEDSEEDEESEEDPDAWVPSAAEKAFLRQEFTSRMHQHFLDGRDGDFDYSAVDDNPELDDLDMVARDEEERYFDDEEPGPALDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P182</accession>
    <name>A0A151P182_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0016087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds DNA as a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CTF/NF-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001345">
        <property type="protein sequence ID" value="KYO42848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P182"/>
    <dbReference type="STRING" id="8496.A0A151P182"/>
    <dbReference type="eggNOG" id="KOG3663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10055441at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019739">
        <property type="entry name" value="CTF/NFI_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF4">
        <property type="entry name" value="NUCLEAR FACTOR 1 B-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00859">
        <property type="entry name" value="CTF_NFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00349">
        <property type="entry name" value="CTF_NFI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="11">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="252"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO42848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="560" mass="62622" checksum="1341A4F657B5E1DE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1C2</accession>
    <name>A0A151P1C2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM71D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM71BL</name>
        <name evidence="4" type="ORF">Y1Q_0016660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GARIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001328">
        <property type="protein sequence ID" value="KYO42894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1C2"/>
    <dbReference type="KEGG" id="amj:102557876"/>
    <dbReference type="eggNOG" id="ENOG502S1VC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9940031at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022168">
        <property type="entry name" value="GARIL-like_Rab2B-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22574">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22574:SF14">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12480">
        <property type="entry name" value="GARIL_Rab2_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgi associated RAB2 interactor protein-like Rab2B-binding" evidence="3">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO42894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="374" mass="42714" checksum="DCA974A786949C8F" modified="2016-06-08" version="1">MTCVGGYRWFPMRFLVSPQPLGFWHQSRSCRASRADPVTDPPTRPTEKARIPLREDLQRHLREGEYSPFQTVAMFESNFIQVTRRGKNVDIHNHQNEAIIGIVSTNNKLPLPDIMLIAHPVPMLQSGQVSSGHYAEQVALTRLLPLQFVRISVYNFNQQSIKIKLINGRSYYLQLYAPPEEQEPLFDRWVSLIYLLHHPPAYYLRPRSFLSRDFLRVKSLPSEEEEKEVMPGSWEKAPADTSPAKEEEEEEEDKSQDSSCENYSRTSIAQGPSTETKEPLAEAKGLRELDTTGKEGDLEEEADDYFFPSSTALSRTRESTLVSSTKDPKAKKLSTRMLVRERSSSLEIKTLFSNISKILHRSSSEEEKGQADHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2R4</accession>
    <name>A0A151P2R4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001208">
        <property type="protein sequence ID" value="KYO43362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2R4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="8883" checksum="660CD9E5C89FBF3B" modified="2016-06-08" version="1">MTGWAVIRDRVNRALRRSKPPLKKPSGSIATLGLEELKDQSPCETLGRHVEGAYTAGILPNHHHRHHYSHQGVFEDFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P580</accession>
    <name>A0A151P580_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein Hox-C4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HOXC4</name>
        <name evidence="11" type="ORF">Y1Q_0001741</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Antp homeobox family. Deformed subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000840">
        <property type="protein sequence ID" value="KYO44208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P580"/>
    <dbReference type="STRING" id="8496.A0A151P580"/>
    <dbReference type="eggNOG" id="KOG0489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF9">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO44208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="184" mass="20780" checksum="6A6745F6E6C926EC" modified="2016-06-08" version="1">MIMSSYLMDSNYIDPKFPPCEEYSQNNYIPDHSPEYYNRTRESSFQHHHQDLYPPARPSYPERQYSCASIQAPGNPAAHQRGHGPTPGGHHLSEKPQQLCEQAALSTSSTSPSPAPPSCNQVNPEHPSSTASKQPIVYPWMKKIHVSSVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5T2</accession>
    <name>A0A151P5T2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Toll-like receptor 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0010996</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000769">
        <property type="protein sequence ID" value="KYO44404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5T2"/>
    <dbReference type="STRING" id="8496.A0A151P5T2"/>
    <dbReference type="eggNOG" id="KOG4641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF554">
        <property type="entry name" value="TOLL-LIKE RECEPTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="15">
        <location>
            <begin position="750"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO44404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="908" mass="102510" checksum="322F7820A63BF000" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5U0</accession>
    <name>A0A151P5U0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1A adrenergic receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Alpha-1A adrenoreceptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Alpha-1C adrenergic receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ADRA1A</name>
        <name evidence="21" type="ORF">Y1Q_0016750</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="18">Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Caveola</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000764">
        <property type="protein sequence ID" value="KYO44441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5U0"/>
    <dbReference type="STRING" id="8496.A0A151P5U0"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004937">
        <property type="term" value="F:alpha1-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055117">
        <property type="term" value="P:regulation of cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019229">
        <property type="term" value="P:regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002233">
        <property type="entry name" value="ADR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001004">
        <property type="entry name" value="ADRA1A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF16">
        <property type="entry name" value="ALPHA-1A ADRENERGIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01103">
        <property type="entry name" value="ADRENERGICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00557">
        <property type="entry name" value="ADRENRGCA1AR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO44441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="335" mass="37576" checksum="8841E6ADF92591AF" modified="2016-06-08" version="1">MSLCIISIDRYVGVSYPLRYPSIMTEKRGLMALLCIWALSVVISIGPLFGWKQPAPEDETICQITEEPGYVLFSALGSFYLPLTIILVMYCRVYVVAKRESKGLTSGLKTEKSHSEEVTLRIHRRNTPEVSGTPSCSKMKHHFSVRLLKFSREKKAAKTLGIVVGCFILCWLPFFLVMPIGSFFPAIKPPDTVFKITFWLGYLNSCINPIIYPCSSQEFKKAFQNILRVQCPLRKQSTKKQSFGFNLNHPSSPAMESGKDVVRIPVGSGETFYKISKSDGVCEWKMFSTMQSMSAKSAISKDQSSCTVAKFQSQSCELPALDSIPWPDLNDVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6R9</accession>
    <name>A0A151P6R9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6R9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9365" checksum="F587D64A80819F3B" modified="2016-06-08" version="1">MSALFLSGNTVSRTHLLNNSLPQGSVLAPALFNGYISDLLVTNLAMPMTWHLILKKGPRLKSRQIFVKKSSYLKNISHVGDATQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7E6</accession>
    <name>A0A151P7E6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain family 2 member L-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0016797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7E6"/>
    <dbReference type="PhylomeDB" id="A0A151P7E6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03593">
        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050828">
        <property type="entry name" value="C-type_lectin/matrix_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033992">
        <property type="entry name" value="NKR-like_CTLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710:SF8">
        <property type="entry name" value="RERATING FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="51"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO44675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="19642" checksum="28F75C09383D763F" modified="2016-06-08" version="1">MLSDHCSYLWFWRRIAGIIIAVAVILLLLWYSLSPPRLPHIEPCPDDWLYYRKKCYYLSEDQADWTFSQNFCLAHGASLAVIDSKQEMHFIMNRMRTRDFWIGLYKQEDEFHWLSGEALDTNLFYINISRYENCGHTASASISASKCRLKKKWLCSTPQLQSSTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8A0</accession>
    <name>A0A151P8A0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Porimin isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMEM123-1</name>
        <name evidence="9" type="ORF">Y1Q_0023024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD164 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000640">
        <property type="protein sequence ID" value="KYO44965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8A0"/>
    <dbReference type="STRING" id="8496.A0A151P8A0"/>
    <dbReference type="eggNOG" id="ENOG502SAV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007947">
        <property type="entry name" value="CD164_MGC24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11337">
        <property type="entry name" value="MUCIN/PORIMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11337:SF14">
        <property type="entry name" value="PORIMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05283">
        <property type="entry name" value="MGC-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO44965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="231" mass="24006" checksum="B487BB57594B4C6F" modified="2016-06-08" version="1">MVVVGARQWEHGDSKRRVASSLQKAENHSKNPGVTTTSQKPSEHSNQNKGGSSPSNVPHSVTSPSATTPHSSTTAKNVIQTTSLDPPETASTSQSANGTQPVNITQSANGTQPVSTTQSANGTQPVTTTKAANSTQSASTTQATTTAISKPQTSMPSKPNITVTTASTPSTSASVSVTVAQARTSRFDVGSFVGGIVLTLGMLAILYIGCKTYHSRRGIRYRTIDEHDAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAP2</accession>
    <name>A0A151PAP2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ufm1-specific protease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UFSP2</name>
        <name evidence="9" type="ORF">Y1Q_0021671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C78 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276111.2">
        <property type="nucleotide sequence ID" value="XM_006276049.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAP2"/>
    <dbReference type="STRING" id="8496.A0A151PAP2"/>
    <dbReference type="GeneID" id="102575577"/>
    <dbReference type="KEGG" id="amj:102575577"/>
    <dbReference type="CTD" id="55325"/>
    <dbReference type="eggNOG" id="KOG2433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417506at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.130:FF:000001">
        <property type="entry name" value="Probable Ufm1-specific protease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049387">
        <property type="entry name" value="UFSP2-like_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF2">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20908">
        <property type="entry name" value="UfSP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UFSP2 second" evidence="8">
        <location>
            <begin position="50"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="7">
        <location>
            <begin position="292"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO46103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="482" mass="54704" checksum="17A9B4EDFE974467" modified="2016-06-08" version="1">MQPGLPLHAALTDVVILEAMDILFRIRGGLDLAFQLAATDEASTKKALKYVFSDLSNKLSSNVMVLRICHSSVYIWPNSGMNTVPSELTDDSACKEIMRFIQYDQEAETKRKLTKKKDKKLQDMQQVVNIDFMLEMTSPSAALAPVIEKENEEHHYVSMTLPVDVVVSISPEETWRNVQNILVNAVHKQLTDMERCIMKYMKGTSIMVPEQFHFMLPGTRHLVTISYPMGVPDDQLESYRKELHGLFHLPSDRPYFRRANAYHFPDEPYKDGYLRNPHMHLHPPGLESGLVCVVHGVYSYHHYMQDRVDDNGWGCAYRSLQTICSWFRHQGYTDRLIPTHQEIQQALVDVGDKPAAFVGSRQWIGSIEVQLVLNQLLGVTSKILFVSQGSELASQGRELANHFKTEGTPVMIGGGVLAHTILGVAWNEITGNIKFLILDPHYTGAEDLTVILEKGWCGWKGPDFWSKDAYYNLCLPQRPKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCN6</accession>
    <name>A0A151PCN6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyltransferase NSUN6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NSUN6</name>
        <name evidence="8" type="ORF">Y1Q_0014380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCN6"/>
    <dbReference type="STRING" id="8496.A0A151PCN6"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21150">
        <property type="entry name" value="PUA_NSun6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF34">
        <property type="entry name" value="TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="261"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO46768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="463" mass="50574" checksum="1D348DDE200D5423" modified="2016-06-08" version="1">MTCAAAQSPARPGAELLRLSPAVAAPAAVVHFEGYLNNVFRNQELVTALDSQEAEKKYKCLLSHLPHPPAFTTVRVNTHLTSVKHVKNLLFEEIEKQFKGLNVPILEHPELQDILLIPVIGPRKDLQQQLSEVIVGAQCGSAVLRGAHVYVPGIISASKFMKAGDMVSVYSDIEGKCKRGAKEFLGTKVFLGNGISELSRNEIFSPSGPLKGMGVRMTDPVYLSPSFDNVLSSYLFLQNLPSAVVSHVLNPQPGERILDMCAAPGGKTTHLATLMHDQGEVIAMDKIASKVKKITQNAALLQLNCIKAFCCDGTKAFAVRKTEDTQGPPFLAESFDRILLDAPCSGMGQRPNMAYSWTLKEVTSYQPLQRKLFTVAVKLLKPGGILVYSTCTITLAENEEQVAWALENFPCLQLQSQEPHIGGEGMMGARLSLDKLKLLQRKRSFSLVFSTAHALSQTVDNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE23</accession>
    <name>A0A151PE23_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0002202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000476">
        <property type="protein sequence ID" value="KYO47184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PE23"/>
    <dbReference type="STRING" id="8496.A0A151PE23"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF134">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 2, SUBFAMILY AB, POLYPEPTIDE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO47184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="113" mass="12776" checksum="68B03BAD90120370" modified="2016-06-08" version="1">MKDRFWKLKWRMSDLEVDQGNDGKITQICSGRVPENTIILSNIDSVLTDPGQWETPEEFNPNHFLDKDGNVVSRGAFLPFSTVSEDAVGSQMTSFWTSPVPNLWKPFAAELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEU7</accession>
    <name>A0A151PEU7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0019638</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEU7"/>
    <dbReference type="STRING" id="8496.A0A151PEU7"/>
    <dbReference type="eggNOG" id="KOG1056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15454">
        <property type="entry name" value="7tmC_mGluR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06376">
        <property type="entry name" value="PBP1_mGluR_groupIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000196">
        <property type="entry name" value="Glutamate metabotropic receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000009">
        <property type="entry name" value="Glutamate receptor, metabotropic 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000176">
        <property type="entry name" value="metabotropic glutamate receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001786">
        <property type="entry name" value="GPCR_3_mGluR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01054">
        <property type="entry name" value="MTABOTROPC4R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00979">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="556"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="556"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO47509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="881" mass="98580" checksum="512837A4C465D603" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEV4</accession>
    <name>A0A151PEV4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline-rich protein PRCC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PRCC</name>
        <name evidence="2" type="ORF">Y1Q_0012431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000456">
        <property type="protein sequence ID" value="KYO47295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEV4"/>
    <dbReference type="STRING" id="8496.A0A151PEV4"/>
    <dbReference type="eggNOG" id="KOG3903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO47295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="368" mass="40591" checksum="D1FB96DF17E65688" modified="2016-06-08" version="1">MPLGAKSKTKKRGEPVRIAAPELPRGESDSEEDEPAKKKNSLQGRGEGSGLSALLPQPKNSTVKETNRVLLPYAFTRKAAENAPESKPARAPTSSSKTKPLFKPAVATTPSPSAIKAAAKSAALQVTKQITQEEDDSDEEVEPENYFSLSDKSEPSVVSTEAYVYSGTVVTEDPPPGTEPEPQFQDAAANAPLEFKTAVGSSSTQHSWAPKPGEEYGDQSYNQFPGYSDANATGAYYQDYYSSGYYQEMEPAQGPPQETGSDSSFIDDEAFKRLQGKRNRGREEINFVDIKGDDQLSGAQQWLTKSLTEEKTMKSFSKKKGDQPTGQQRRKHQITYLIHQAKERELELKNTWSENKLSRRQTQAKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PF13</accession>
    <name>A0A151PF13_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ASZ1</name>
        <name evidence="16" type="ORF">Y1Q_0019690</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PF13"/>
    <dbReference type="STRING" id="8496.A0A151PF13"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071546">
        <property type="term" value="C:pi-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09521">
        <property type="entry name" value="SAM_ASZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000192">
        <property type="entry name" value="Ankyrin repeat, SAM and basic leucine zipper domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042650">
        <property type="entry name" value="Asz1_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157:SF3">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="15">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO47579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="468" mass="51663" checksum="74D5EB5162E390BC" modified="2016-06-08" version="1">MARVSRSLAAPGGCSDSDSDEDCWFLGLGHDAPQTFNDTLQIKDKEEILKKALTSGNVSLVEELLNSGVSVDISFQFGWTPLMYAASVANVELVRILLDRGANASFEKDQYTVLMSACTAHASEEQILKCVELLLSRNANPSVACRKKMSPLMYAAREGHPQVVALLVAHGSQINGQDENGYTALMWAARQGHKRVIFKLLELGADKSLQTKDGKTAGEIAKSNKHSELFSLLSLTANPLQGRVQSLVKEEAVHKLLKAIPDAPRGHSVSSYTAFGDLEVFLHGLGLEHVAELLKERDITLRQLLTMGKDDFAQFGITNTRDQQKILEAAKELQIEELKFGELPEVMKLEFSGDEFLTFLLKLNKQCGHLTAAVQSIITQLPSNSQKIVLEWGPPQSFTKVCEDLVCSVEDLGEEVSKLKDLMQKFQNGQKNDPSLVKSIFLRTLNQNFKDSSTTVLKDFYSLLVMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PF79</accession>
    <name>A0A151PF79_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="22">A disintegrin and metalloproteinase with thrombospondin motifs 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ADAMTS4</name>
        <name evidence="22" type="ORF">Y1Q_0019747</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PF79"/>
    <dbReference type="eggNOG" id="KOG3538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
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    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000010">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1620.60:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF165">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08685">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 22" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586967" evidence="19">
        <location>
            <begin position="19"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="20">
        <location>
            <begin position="162"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GON" evidence="21">
        <location>
            <begin position="1619"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="active site" evidence="15 18">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="266"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="284"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="472"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="476"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO47658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1819" mass="205414" checksum="9033FD475973F5E7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGZ3</accession>
    <name>A0A151PGZ3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Forkhead box protein P3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FOXP3</name>
        <name evidence="13" type="ORF">Y1Q_0006640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000199">
        <property type="protein sequence ID" value="KYO48397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGZ3"/>
    <dbReference type="STRING" id="8496.A0A151PGZ3"/>
    <dbReference type="eggNOG" id="KOG4385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20066">
        <property type="entry name" value="FH_FOXP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047413">
        <property type="entry name" value="FH_FOXP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF2">
        <property type="entry name" value="FORKHEAD BOX P3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="48"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="48"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO48397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="160" mass="18480" checksum="F7DD9B955B24EB7F" modified="2016-06-08" version="1">MSQKRAKGPSSAAGPKDTLETPLWGHHSLSFYPELGPSLEYYRVSTARPPFTYAALIRWAIMESPERQLTLNEIYHWFSRSFGYFRHNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEGEFQRRRSQRFPRDPDLRGLLPPLPYAPAEGAWRPAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHN8</accession>
    <name>A0A151PHN8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Homeobox protein orthopedia</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">OTP</name>
        <name evidence="16" type="ORF">Y1Q_0003976</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHN8"/>
    <dbReference type="STRING" id="8496.A0A151PHN8"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151PHN8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000124">
        <property type="entry name" value="Orthopedia homeobox b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051895">
        <property type="entry name" value="OTP_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="15">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO48550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="325" mass="34283" checksum="E0391F1833765C26" modified="2016-06-08" version="1">MLSHADLLDARLGMKDAAELLGHREAVKCRLGVGGSDPGGHPGDLAPNSDTVEGATLLPGDDITTVGSNPSSLAASAKDPDKQQGQQGGQNPSQPGQQQGQQKQKRHRTRFTPAQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRAPGTLLPTPGLPQFPSAAAAAAAAMGDSLCSFHANDTRWAAAAMPGVSQLPLPPALGRQQAMAQSLSQCSLAAGPPPNSMGLSNSLAGSNGAGLQSHLYQPAFPGMVPASLPGPSNVTGSPQLCSSPDSSDVWRGTSIASLRRKALEHTVSMSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZQ8</accession>
    <name>A0A151LZQ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UBE2E3</name>
        <name evidence="11" type="ORF">Y1Q_0011446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZQ8"/>
    <dbReference type="STRING" id="8496.A0A151LZQ8"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="84"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO17757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="230" mass="25439" checksum="54B2A594A7601681" modified="2016-06-08" version="1">MSVCFVETDQASVALKALQKFTTMSSDRQRSDDESPSTSSGSSDADQRDPPAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0B0</accession>
    <name>A0A151M0B0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase MARCHF7</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Membrane-associated RING finger protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Membrane-associated RING-CH protein VII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase MARCHF7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MARCH7</name>
        <name evidence="20" type="ORF">Y1Q_0011585</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0B0"/>
    <dbReference type="STRING" id="8496.A0A151M0B0"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16812">
        <property type="entry name" value="RING_CH-C4HC3_MARCH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000108">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052297">
        <property type="entry name" value="RING-CH-type_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471">
        <property type="entry name" value="MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="19">
        <location>
            <begin position="441"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="258"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00084030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO17957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="590" mass="66097" checksum="8083102B9F2D80AB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0L0</accession>
    <name>A0A151M0L0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0L0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="156" mass="18466" checksum="CC6DEA47253DA5EC" modified="2016-06-08" version="1">MSSLITWVYSRLESLCTLHIYGKTATQPALGRPFPVDLYRDPWHKKLEFWGKEDVHLLNHKFGLHYHPYPSSPPHIPQGKSFTEEKLKWILAFTSVFSNYCFCLFLNVKQWFLRDSNSLWYKIVVVYNQVPRDSVQNCYTILYILLHTSLPNTKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0Q9</accession>
    <name>A0A151M0Q9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Speckle-type POZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SPOP</name>
        <name evidence="8" type="ORF">Y1Q_0011666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0Q9"/>
    <dbReference type="STRING" id="8496.A0A151M0Q9"/>
    <dbReference type="GeneID" id="102562894"/>
    <dbReference type="KEGG" id="amj:102562894"/>
    <dbReference type="CTD" id="339745"/>
    <dbReference type="eggNOG" id="KOG1987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M0Q9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18519">
        <property type="entry name" value="BACK_SPOPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18343">
        <property type="entry name" value="BTB_POZ_SPOPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO18072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="392" mass="44458" checksum="C03CE56A2B5EC3BB" modified="2016-06-08" version="1">MSRVPTPPPPGEMSSGPVAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGPNDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQSNTNTLKVPECRLAEDLGNLWETTKFTDCSFYVGGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLEKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADILILADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNQATDIMETAGWKSMIHSHPHLVAEAFRALASAQCPQFGIPRKRLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0T4</accession>
    <name>A0A151M0T4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Macrophage receptor MARCO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MARCO</name>
        <name evidence="15" type="ORF">Y1Q_0011707</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006278022.2">
        <property type="nucleotide sequence ID" value="XM_006277960.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0T4"/>
    <dbReference type="STRING" id="8496.A0A151M0T4"/>
    <dbReference type="GeneID" id="102571058"/>
    <dbReference type="KEGG" id="amj:102571058"/>
    <dbReference type="CTD" id="8685"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037288at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="437"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="140"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO18128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="532" mass="53986" checksum="1525A1E4C77A6A1C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0X2</accession>
    <name>A0A151M0X2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Kalirin</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Protein Duo</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="ORF">Y1Q_0011735</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="37">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M0X2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13240">
        <property type="entry name" value="PH1_Kalirin_Trio_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13241">
        <property type="entry name" value="PH2_Kalirin_Trio_p63RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11852">
        <property type="entry name" value="SH3_Kalirin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11853">
        <property type="entry name" value="SH3_Kalirin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14115">
        <property type="entry name" value="STKc_Kalirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000152">
        <property type="entry name" value="kalirin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000091">
        <property type="entry name" value="kalirin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000038">
        <property type="entry name" value="kalirin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000040">
        <property type="entry name" value="kalirin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000325">
        <property type="entry name" value="kalirin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000368">
        <property type="entry name" value="kalirin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000034">
        <property type="entry name" value="kalirin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000003">
        <property type="entry name" value="kalirin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000024">
        <property type="entry name" value="Kalirin RhoGEF kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000023">
        <property type="entry name" value="Kalirin RhoGEF kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000032">
        <property type="entry name" value="Kalirin RhoGEF kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000040">
        <property type="entry name" value="Kalirin RhoGEF kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000008">
        <property type="entry name" value="rho guanine nucleotide exchange factor 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000015">
        <property type="entry name" value="triple functional domain protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
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            <dbReference type="ARBA" id="ARBA00022443"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022658"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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            <dbReference type="ARBA" id="ARBA00048679"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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            <dbReference type="PROSITE" id="PS50010"/>
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            <dbReference type="PROSITE" id="PS50011"/>
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        <source>
            <dbReference type="PROSITE" id="PS50191"/>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="KYO18167.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2926" mass="333778" checksum="2472FD621FB9492D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1K5</accession>
    <name>A0A151M1K5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0008470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1K5"/>
    <dbReference type="STRING" id="8496.A0A151M1K5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001872">
        <property type="term" value="F:(1-&gt;3)-beta-D-glucan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071226">
        <property type="term" value="P:cellular response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03593">
        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042808">
        <property type="entry name" value="CLEC7A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033992">
        <property type="entry name" value="NKR-like_CTLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="141"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO18336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="384" mass="43816" checksum="31D979B4E76451C8" modified="2016-06-08" version="1">MITYSDLKLDSSKHGGKVRQKEMTAYSELKFQNQAEQQRGRRFLEAGNRGAGGSPSPSRRNKAPPRRWQCATVILGILCLVLLIATGVLSYLVLDTKLSPGKGSSSEQSPSCPDQQPGLPEIPDEQRGDTGQKCPARWTTAEGRSYLFSPEKGTWEHCKSSCMFQSARLLSIENKKELDFIRQELYQYYEDRKSVTWYYPFWIGLSHDPESRKWVWEDNTALSSGLFDLQDLSHQNDQGRVCAYVQGNAARDTMADITFPKGNTSGQDFLIQDLIILFCRDFIRQELYRYYEDRKGVLWYYPFWIGLSYDPGSRKWVWEDNTALSSGLFDLQDLSHQNDPGRVCAYIQGSGQMPLLVFQLRDHHPSLLNCAEKAKHHQAQAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1W7</accession>
    <name>A0A151M1W7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TALPID3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1W7"/>
    <dbReference type="STRING" id="8496.A0A151M1W7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029246">
        <property type="entry name" value="TALPID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721">
        <property type="entry name" value="KIAA0586 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721:SF2">
        <property type="entry name" value="PROTEIN TALPID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15324">
        <property type="entry name" value="TALPID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="68274" checksum="0649F6119DBCBA27" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M497</accession>
    <name>A0A151M497_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 39A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0003492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
        <property type="protein sequence ID" value="KYO19349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M497"/>
    <dbReference type="eggNOG" id="KOG3783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF3">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO19349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="65682" checksum="A0889C61F6C305EF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M586</accession>
    <name>A0A151M586_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0007549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006584">
        <property type="protein sequence ID" value="KYO19641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M586"/>
    <dbReference type="STRING" id="8496.A0A151M586"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF58">
        <property type="entry name" value="VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO19641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="266" mass="30636" checksum="3BA492E85BFA1693" modified="2016-06-08" version="1">MKTSPHSCCSSSKEETNDKSFYLRNPDKNYSSNQWTSSCFCYIGAQVNLLVHTLSLPSTPTLPGFSIVIYSSFEHQREKRRNCQEVTPVPELLSDKYIAGPQSAILSYWNNRTGPSERNWLKSLDVYAPLEKRTFFLFYSISLVKLLLFYSYNKLTSIPEEIKYLTNLQYFALTKNHIEKLPDGLFQCKKLQYLLLGNNSLMSLSPLVGQLLNLIQLELVGNYLESLPAELEECQFLKRSCLIVEESLLKTLPLCVRERLQMCLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5K8</accession>
    <name>A0A151M5K8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0005915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006533">
        <property type="protein sequence ID" value="KYO19806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5K8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000538">
        <property type="entry name" value="zinc finger protein 853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO19806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="153" mass="17809" checksum="8C9F3455E4555A5B" modified="2016-06-08" version="1">MDSLGPEKEPWHESQGRPQTQKENVAMSQDWYIPLGRKIHQCTECRKNFIYLQDLSQHECARQHCTQCGKKFGQFSDLARHWCMHTREKPHQYSECGEKPHQCSECGKVFTQSSTLAQHHTGKKSYRCSECEKSFANPDGLTQQQRIHTVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5N4</accession>
    <name>A0A151M5N4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0006793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006526">
        <property type="protein sequence ID" value="KYO19822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5N4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584764" evidence="2">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO19822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="125" mass="13930" checksum="DB060DE392F33BF5" modified="2016-06-08" version="1">MCQLWAHSLDLLFTAIFLLHSQQTPMDMEGIAEECWPPWRGTINPYQEMETVSHEDKRTQTNLPLHAEASTQAEGPGHEHTSTQTRALCLSKMGCQTEPLPVTNANTQRLANANNDQDTGRGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M744</accession>
    <name>A0A151M744_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein Jade-1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">JADE1</name>
        <name evidence="10" type="ORF">Y1Q_0010827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the JADE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M744"/>
    <dbReference type="STRING" id="8496.A0A151M744"/>
    <dbReference type="eggNOG" id="KOG0954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15705">
        <property type="entry name" value="ePHD_JADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15680">
        <property type="entry name" value="PHD_JADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000004">
        <property type="entry name" value="Jade family PHD finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000030">
        <property type="entry name" value="Protein Jade-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039549">
        <property type="entry name" value="JADE2_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039548">
        <property type="entry name" value="JADE2_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF84">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE JADE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="230"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="282"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="712"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO20291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="861" mass="97491" checksum="00DB39CA10A378C5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7J8</accession>
    <name>A0A151M7J8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006382">
        <property type="protein sequence ID" value="KYO20503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7J8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="100" mass="10911" checksum="FB03EACB17EAE783" modified="2016-06-08" version="1">MGSGGRRKHSNGQMGPEENAVLGAQRPIPANRSLCNQNLEDGGGCHLLQHQLPRTLCILHSRSLAEEVKSFTSMCVESSCQKKLSSLLDIRPEQVGLELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7W7</accession>
    <name>A0A151M7W7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0012516</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7W7"/>
    <dbReference type="STRING" id="8496.A0A151M7W7"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000005">
        <property type="entry name" value="Solute carrier family 27 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF12">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="19">
        <location>
            <begin position="67"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="20">
        <location>
            <begin position="465"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO20618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="589" mass="66980" checksum="F03E74E03B7E242F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M837</accession>
    <name>A0A151M837_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M837"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584793" evidence="1">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10596" checksum="D377F2036CD8DE05" modified="2016-06-08" version="1">MRLLLPLALIGPFVIQGGALDVQVVGLCDSTQTTSKTFLKKLIWALWNISRNDRSSDSYQIISMMLLPLYPGLSDIQEDLSWLIPGCLVAIWFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBM3</accession>
    <name>A0A151MBM3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ACCS</name>
        <name evidence="6" type="ORF">Y1Q_0000497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274148.1">
        <property type="nucleotide sequence ID" value="XM_006274086.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBM3"/>
    <dbReference type="STRING" id="8496.A0A151MBM3"/>
    <dbReference type="GeneID" id="102562437"/>
    <dbReference type="KEGG" id="amj:102562437"/>
    <dbReference type="CTD" id="84680"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MBM3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF17">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="422"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO21810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="890" mass="101721" checksum="6A6B7D92587F942F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEG5</accession>
    <name>A0A151MEG5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U7 snRNA-associated Sm-like protein LSm11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LSM11</name>
        <name evidence="3" type="ORF">Y1Q_0010944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006228">
        <property type="protein sequence ID" value="KYO22901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEG5"/>
    <dbReference type="STRING" id="8496.A0A151MEG5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005683">
        <property type="term" value="C:U7 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071209">
        <property type="term" value="F:U7 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01739">
        <property type="entry name" value="LSm11_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039267">
        <property type="entry name" value="Lsm11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034109">
        <property type="entry name" value="Lsm11_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21415">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21415:SF1">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO22901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="202" mass="22360" checksum="E22F6C2C7E0C6AD8" modified="2016-06-08" version="1">MQSLGIMLFDVCKAVHEGSPLGELHRCVRDGVKINVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAFYNEPQLTLTRLFDRLKLQESSEKKGADTKTEPEETATTSEPQPLGRKVGSGWGRAEEERETQKHVGRGGEKKTAGDSLPLAVRNEADLPGRTAQTEGTGAGATAARSQPRKKKRPKRMKCSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEH9</accession>
    <name>A0A151MEH9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ovomucoid-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0010956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006228">
        <property type="protein sequence ID" value="KYO22917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEH9"/>
    <dbReference type="STRING" id="8496.A0A151MEH9"/>
    <dbReference type="KEGG" id="amj:106737655"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01327">
        <property type="entry name" value="KAZAL_PSTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000036">
        <property type="entry name" value="Ovomucoid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000037">
        <property type="entry name" value="Ovomucoid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001239">
        <property type="entry name" value="Prot_inh_Kazal-m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21312:SF28">
        <property type="entry name" value="OVOINHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21312">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00290">
        <property type="entry name" value="KAZALINHBTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584998" evidence="8">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="86"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO22917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="265" mass="28841" checksum="5A28E5211B81DC0F" modified="2016-06-08" version="1">MKTTRGFVLVFLAFGCFSDVASGVELDCSEYPKDTTPEGKEVMFCTKIYSPVCGTDNKTYSNECMLCAHNLEHGTYVKIKHKGACRKLDCSTYPKGTTPEGKEVIACLEIYSPVCGTDNKTYSNECMLCAHNLEHGTNIGIRHKGECGKLVCSKYTKVSMSGVQSLACTPNYKPVCGSNNVTYASECMLCAYNVEHGANITLQHQGPCKKKPEPVDCRDAAGPACTLEYMPICGSDGKTYGNKCTFCNAVAQSKKTLTFVRYGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEL6</accession>
    <name>A0A151MEL6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Voltage-dependent calcium channel subunit alpha-2/delta-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO22945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEL6"/>
    <dbReference type="STRING" id="8496.A0A151MEL6"/>
    <dbReference type="eggNOG" id="KOG2353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585003" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="125" mass="14147" checksum="4E60BBDD844EC5DA" modified="2016-06-08" version="1">MVPALCGHIVLLLVLSAPAADCYSFPQQYTMQYWARRLEQEIDGVMRIFGGVQQLRGIYNENRNLFEVKENVPRKLVEKVAGDIESLLAKKVRALKYSFSNELVPLDLEEGKLDCATLSLECDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEU6</accession>
    <name>A0A151MEU6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat-containing protein 31 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">WDR31</name>
        <name evidence="4" type="ORF">Y1Q_0005523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014458154.2">
        <property type="nucleotide sequence ID" value="XM_014602668.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEU6"/>
    <dbReference type="STRING" id="8496.A0A151MEU6"/>
    <dbReference type="GeneID" id="102565134"/>
    <dbReference type="KEGG" id="amj:102565134"/>
    <dbReference type="CTD" id="114987"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MEU6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040066">
        <property type="entry name" value="WDR31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869">
        <property type="entry name" value="SPERMATID WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19869:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="270"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO23052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="363" mass="40025" checksum="178DC43FD0140421" modified="2016-06-08" version="1">MPEMLSTIHCIARAAFICNTMGKLQSKINHSTSKYRAGGYMEENSPVKAIQQYSPAHTDAVTSVAALKSDLCVSGGKDKTVVIYNWRSGAVLKRFLGHEREVTKVACVFESNRFFSASRDKTVMMWELSGNSGPSQHFPGHDLVVTGLVVSPDASQLCTGSRDNTICKWDIETGECLCRTAISRNLVTHLCWVPREPYFIQTSEDKLIRMWDSRKLQVAHTFPGKQHIQTYCDVSQDGQYCISSSNGFAGEGCEATLWDLRQTKNRVCEYKGHFQTIASCIFLPKGLGLTPVIATSSHDCMVKIWNQDTAACLTTLCLEGSGPLASLAVCDSSTLLCASFNSGIHLLRINNAKDLELQEVAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGH5</accession>
    <name>A0A151MGH5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGH5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO23608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10278" checksum="951354FF45BFF18A" modified="2016-06-08" version="1">MALGHQMAGDTSRFPGWGSSLDTYQFQHSRIRCIHSMLPSCAAWPLSLSYLAPEHLRFSVNLREKRDPSEGRLQGRNCRRAGPRGKTLIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJ80</accession>
    <name>A0A151MJ80_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Taste receptor type 1 member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sweet taste receptor T1R2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0023253</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms heterodimers with TAS1R3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJ80"/>
    <dbReference type="STRING" id="8496.A0A151MJ80"/>
    <dbReference type="eggNOG" id="KOG1056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903767">
        <property type="term" value="C:sweet taste receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033041">
        <property type="term" value="F:sweet taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF517">
        <property type="entry name" value="TASTE RECEPTOR TYPE 1 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="2" id="KW-0919">Taste</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO24566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="237" mass="27043" checksum="B6EE940ECE82D089" modified="2016-06-08" version="1">MCLLMLASLVICFLNILAYVGIPTVFKCVWRQTVYSLGFTLCISCIVIRSLQIVCIFKLMAKLPKAYNYWTKYKGPYIFMAVVLALKAVILMINFIISSPAPVELPLEDNPAVLVLDCKKTHAFLEMLDTALDMSLSVLCFCFAYAGKEFPKNYNEAKYITLWTTSYFTTWVILFVAITAYPGVLVPFFNALFNVVNLLGIVIGYFGPKCYIIFFHPERNTSAYFQTDIQTYTMRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJD2</accession>
    <name>A0A151MJD2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Endosialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CD248</name>
        <name evidence="19" type="ORF">Y1Q_0020330</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006042">
        <property type="protein sequence ID" value="KYO24648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJD2"/>
    <dbReference type="STRING" id="8496.A0A151MJD2"/>
    <dbReference type="eggNOG" id="ENOG502QQKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990430">
        <property type="term" value="F:extracellular matrix protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051505">
        <property type="entry name" value="C-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789">
        <property type="entry name" value="CHONDROLECTIN VARIANT CHODLFDELTAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789:SF4">
        <property type="entry name" value="ENDOSIALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001775">
        <property type="entry name" value="CD93/CD141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585164" evidence="16">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="18">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="402"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO24648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="447" mass="47486" checksum="B3A2959F62C066CF" modified="2016-06-08" version="1">MRLLLLFVLCLPLPGLVPAQPSAARCSPGGCVALFPQPRPFLEAWRSCRDRGGDLATLKHPEEAADVAQLLDEAPRPSPGPRRYWIGLQRQPRQCQPRRPLRGYTWTTGEQDTAYTNWAREEAPASCSLARCVALSHIAGAHQPPAWLDGACTAPADGYVCRFAHTRACPSLGAASYATPFGTVPGPLSHVPFGTVAAMSCGASTPASALCRYREDGTVGWSPPGPPCEEEAASHEGWCEGDNGGCQELCMDTGPSHTCACHSGRALLADGRSCGPAPPCREHPCEYACASEGTGYRCLCPAGHRLARDGHSCEDVDECAEAGGAPCEQLCENAPGGYRCRCRLGYAGDGAGGCGDVDECELPGVCHQMCVNYEGGFECFCAEGYELQADGVSCAPLGAAPGPPFAWPRPPEEEEEEEEEEEEEDLAYSWTPGHLGSSDQVFRPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJV8</accession>
    <name>A0A151MJV8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006009">
        <property type="protein sequence ID" value="KYO24749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJV8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO24749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="9495" checksum="424651EE8EDEF2F0" modified="2016-06-08" version="1">MYVKTGSARPRCPSRNSPGPVTSTCVTPGGQKSPSARASSLLSDERSQKALDQRLEDSVLLISLPSKGMSSHLLASCFHFHVLIVLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK88</accession>
    <name>A0A151MK88_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK88"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="124" mass="14399" checksum="ED56F7E086871590" modified="2016-06-08" version="1">MALEYSSGLLDGHYQCLMTRLVLDELNIPSITVCAEYCTGEGLTRTELYFVPVESSPWREQWRSNLFHGGAEKLHKSILKTKEREQRSRIHHRYVPILRGGIGLLDSAWFLFDQTSDVWFQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMH0</accession>
    <name>A0A151MMH0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptonemal complex central element protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SYCE2</name>
        <name evidence="3" type="ORF">Y1Q_0001160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005675">
        <property type="protein sequence ID" value="KYO25716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMH0"/>
    <dbReference type="STRING" id="8496.A0A151MMH0"/>
    <dbReference type="eggNOG" id="ENOG502S7EK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000801">
        <property type="term" value="C:central element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034609">
        <property type="entry name" value="Syce2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28398">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28398:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO25716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="193" mass="21876" checksum="C0FC7FE5FC457E4A" modified="2016-06-08" version="1">MNHYWCFADVYPINTKIKAVTMSNQEGENEEPAQELAIPDSLFFATLERDEFSSECPSRKEPPPASPTYPGADTAMAALDGKSSNYLAALDANIENLQKRTQQLIDKINENRKKDHTVMSNFRESLLLKVSTLAEKLEEMMFLIYDLHNKLMQDKLQELSDAMGRISQIGAELRQVCHAVEAAYKDLCIQPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPP4</accession>
    <name>A0A151MPP4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor SPT20-like protein isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SUPT20H</name>
        <name evidence="4" type="ORF">Y1Q_0010405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005510">
        <property type="protein sequence ID" value="KYO26443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019353783.1">
        <property type="nucleotide sequence ID" value="XM_019498238.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPP4"/>
    <dbReference type="STRING" id="8496.A0A151MPP4"/>
    <dbReference type="GeneID" id="102569237"/>
    <dbReference type="CTD" id="55578"/>
    <dbReference type="eggNOG" id="ENOG502QS30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MPP4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="3">
        <location>
            <begin position="75"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="718"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO26443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="811" mass="88075" checksum="49A238F708212743" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQG2</accession>
    <name>A0A151MQG2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein 196</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMEM196</name>
        <name evidence="9" type="ORF">Y1Q_0019235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQG2"/>
    <dbReference type="STRING" id="8496.A0A151MQG2"/>
    <dbReference type="KEGG" id="amj:102560601"/>
    <dbReference type="eggNOG" id="ENOG502RXKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10016951at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037661">
        <property type="entry name" value="TMEM196"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28681">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28681:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO26775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="173" mass="18552" checksum="227CED2E2B2D7284" modified="2016-06-08" version="1">MCTSSQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLVLSEHKPQLGDSSPFLLCGICGILCAKKKTGLVMILFSACCICGLIGGILNFQFLRALTKKSSALYSLHLTSMSLACIGIGGCTLSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKEMTDNLSNGGPQLIYNGKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQL4</accession>
    <name>A0A151MQL4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQL4"/>
    <dbReference type="STRING" id="8496.A0A151MQL4"/>
    <dbReference type="eggNOG" id="KOG3863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="164" mass="18562" checksum="955EB98E9F4D4410" modified="2016-06-08" version="1">MSSVFTPAYEELHTQMFLNEVTTCRLPAGKDGPVMNIVTEKVCLERSVFITRNDRFGQGREEPEPSGAAAPGASDCSAASQDVDWKVSQEALDYSYSHKGNEQSNLQKRKEEEIKQLHNEENEKRNKTDGEESDNRDFSTESITENNSLLTTEKFTGRYSTFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR16</accession>
    <name>A0A151MR16_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR16"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="110" mass="12341" checksum="5EE43EC89557B9FD" modified="2016-06-08" version="1">MPCCPPPGAHVDAAPTLGFFKQDEKNSVFHNNVAGYLTQFHRKWRQNKFCLSRNRSFWVAGHTRRKQAELTSERSQPDQLVPGMNLSNHTGVTGKTVPITFVAEHLAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSF4</accession>
    <name>A0A151MSF4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spermatogenesis-associated protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0013467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005173">
        <property type="protein sequence ID" value="KYO27445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSF4"/>
    <dbReference type="STRING" id="8496.A0A151MSF4"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11973">
        <property type="entry name" value="SH3_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000002">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000077">
        <property type="entry name" value="spermatogenesis-associated protein 13 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544:SF5">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="707"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="800"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO27445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1213" mass="138777" checksum="065E6C2B78C54229" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTF0</accession>
    <name>A0A151MTF0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Y1Q_0000373</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel HCN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005096">
        <property type="protein sequence ID" value="KYO27791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTF0"/>
    <dbReference type="STRING" id="8496.A0A151MTF0"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000031">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000002">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000007">
        <property type="entry name" value="Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF7">
        <property type="entry name" value="POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0114">cAMP</keyword>
    <keyword evidence="7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="19" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="25">
        <location>
            <begin position="365"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="590"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO27791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="628" mass="71871" checksum="7146DAF33BCCB83D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTS9</accession>
    <name>A0A151MTS9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC25A11</name>
        <name evidence="21" type="ORF">Y1Q_0020535</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis. Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71587"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71599"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71591"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71603"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71595"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with SMIM26.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005051">
        <property type="protein sequence ID" value="KYO27921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006262960.2">
        <property type="nucleotide sequence ID" value="XM_006262898.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTS9"/>
    <dbReference type="STRING" id="8496.A0A151MTS9"/>
    <dbReference type="GeneID" id="102575522"/>
    <dbReference type="KEGG" id="amj:102575522"/>
    <dbReference type="CTD" id="8402"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015139">
        <property type="term" value="F:alpha-ketoglutarate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000013">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="214"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO27921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="311" mass="34164" checksum="685B89A28C3B5229" modified="2016-06-08" version="1">MAVAAGTGGPERARTSPQAVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYRTSFHAVGSILRHEGIRGIYTGLSAGLLRQATYTTTRLGIYTVLLERLTRDDGTPPPFLLKAALGMVAGAAGAFVGTPAEVALIRMTADGRLPPDQRRGYTNVFNALVRITREEGVFTLWRGCVPTMARAVVVNAAQLASYSQSKQFLLDSGYFRDDILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYRNGLDVLAKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKFYHRLFLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTX6</accession>
    <name>A0A151MTX6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorting nexin-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SNX14</name>
        <name evidence="12" type="ORF">Y1Q_0014172</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO27972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019352356.1">
        <property type="nucleotide sequence ID" value="XM_019496811.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTX6"/>
    <dbReference type="STRING" id="8496.A0A151MTX6"/>
    <dbReference type="GeneID" id="102575385"/>
    <dbReference type="KEGG" id="amj:102575385"/>
    <dbReference type="CTD" id="57231"/>
    <dbReference type="eggNOG" id="KOG2101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5957963at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MTX6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06877">
        <property type="entry name" value="PX_SNX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08722">
        <property type="entry name" value="RGS_SNX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000004">
        <property type="entry name" value="sorting nexin-14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000007">
        <property type="entry name" value="sorting nexin-14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037436">
        <property type="entry name" value="SNX14_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037892">
        <property type="entry name" value="SNX14_RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF44">
        <property type="entry name" value="SORTING NEXIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="11">
        <location>
            <begin position="129"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="9">
        <location>
            <begin position="335"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="569"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO27972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="945" mass="109989" checksum="8C6F76C7B33DA886" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVY0</accession>
    <name>A0A151MVY0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0000825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004838">
        <property type="protein sequence ID" value="KYO28662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVY0"/>
    <dbReference type="eggNOG" id="ENOG502T2DT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="4">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO28662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="424" mass="48344" checksum="61865E5AA488DD72" modified="2016-06-08" version="1">MGPLHLVRVDEKGQLALDEGTLSHCLEQGKVGDAPICLISIVGEQHQEKSILMNCLIHQLQNQDAAWMGQKDQPVEGSDWQGGYQTMRKGVWIWGEPFWVQGPHGKVAVFLVDTEGSMDLHHQLETSIKLCVFSVLLGSYQNLDLLVHDYPTSFDCGVEGGKKYLSHVIQELEASPNHMLTLEALKAAGTRCYLMPHPGKFISCRNGMLPDTDKDFREHLRDYIASLTSSAGTHIWKDQNGQVLTGRKLAEKIRHQGLDTQTMDQSLKVTLNEMKQQLETKCKDLLQDCQEQLLGEEPEKQAVLGELKKEWSRKEKDFLDASENKYKEVVVSANKASENAMKEMEQFLQEQAKVKCLQVPPSEMNEKLKAKRQKLLQACQEKLLHDESKPLAILEELEQWCIRKEEAFLKLYREKYKVLLLYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWD6</accession>
    <name>A0A151MWD6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ectopic P granules 5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EPG5</name>
        <name evidence="6" type="ORF">Y1Q_0009713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261090.2">
        <property type="nucleotide sequence ID" value="XM_006261028.4"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MWD6"/>
    <dbReference type="GeneID" id="102577357"/>
    <dbReference type="KEGG" id="amj:102577357"/>
    <dbReference type="CTD" id="57724"/>
    <dbReference type="eggNOG" id="KOG3622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75419at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058750">
        <property type="entry name" value="TPR_Epg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059030">
        <property type="entry name" value="TPR_Epg5_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26103">
        <property type="entry name" value="TPR_Epg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26573">
        <property type="entry name" value="TPR_Epg5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26106">
        <property type="entry name" value="TPR_Epg5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like TPR" evidence="5">
        <location>
            <begin position="1246"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="Epg5-like central TPR repeats" evidence="4">
        <location>
            <begin position="1710"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO28856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2585" mass="293459" checksum="7D793DCAD575E1FD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWQ3</accession>
    <name>A0A151MWQ3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWQ3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="10623" checksum="07F5BD8130357B9E" modified="2016-06-08" version="1">MYRAGVPCGSVLGSLSATQDTRIQFSDAYTTATLEATNVWTQSGLWILSQWPKLYVLPRTYMGFGNTHLHPAVSDVPLFPEGGLEKSMGEEKTERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWW8</accession>
    <name>A0A151MWW8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alanine--glyoxylate aminotransferase 2, mitochondrial</fullName>
            <ecNumber evidence="29">2.6.1.18</ecNumber>
            <ecNumber evidence="13">2.6.1.40</ecNumber>
            <ecNumber evidence="5">2.6.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">(R)-3-amino-2-methylpropionate--pyruvate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Beta-ALAAT II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Beta-alanine-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">D-3-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">D-AIBAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">D-beta-aminoisobutyrate-pyruvate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="41" type="primary">AGXT2</name>
        <name evidence="41" type="ORF">Y1Q_0009814</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="41 42" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="41">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="39">Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77339"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:18393"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.40"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:18394"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77355"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77363"/>
            <dbReference type="ChEBI" id="CHEBI:35177"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58455"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate</text>
            <dbReference type="Rhea" id="RHEA:77359"/>
            <dbReference type="ChEBI" id="CHEBI:28644"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:58441"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>3-oxopropanoate + L-alanine = beta-alanine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:14077"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.18"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:14079"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77331"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77327"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58802"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77315"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77307"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:197308"/>
            <dbReference type="ChEBI" id="CHEBI:197310"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate</text>
            <dbReference type="Rhea" id="RHEA:77351"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77311"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:77343"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77303"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58326"/>
            <dbReference type="ChEBI" id="CHEBI:197301"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:77323"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:77319"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
            <dbReference type="ChEBI" id="CHEBI:197314"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:24249"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>oxaloacetate + L-alanine = L-aspartate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:77347"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 40">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="41">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.18" evidence="29"/>
    <dbReference type="EC" id="2.6.1.40" evidence="13"/>
    <dbReference type="EC" id="2.6.1.44" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWW8"/>
    <dbReference type="STRING" id="8496.A0A151MWW8"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047305">
        <property type="term" value="F:(R)-3-amino-2-methylpropionate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016223">
        <property type="term" value="F:beta-alanine:pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019481">
        <property type="term" value="P:L-alanine catabolic process, by transamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000055">
        <property type="entry name" value="Alanine--glyoxylate aminotransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000105">
        <property type="entry name" value="alanine--glyoxylate aminotransferase 2, mitochondrial isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF3">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 41" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 40" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00043758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00043777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00043798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00043825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00043826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00044257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00044258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00047892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00049480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00058068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="EMBL" id="KYO28994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="467" mass="51793" checksum="ACB819E6B262B13B" modified="2016-06-08" version="1">MPPCNFSPGNYESYPYDHMLKIRKQNVSPSLATYYKKPLLLHQGHMQWLFDYEGRRYLDLFAGIVTVSVGHCHPKVTAAAQKQLGRLWHTTNIYMHPSIQEYAEKLTALLPDPLKVVYLTNSGSEANDLAMFMARLYTRNFDIICFRGGYHGGSPYTQGVTSIRSYKHGVANGFGCPTTMLPDVFRGPWGGSHCRDSPVQTVRKCSCSAGHCHANDQYIEQFKDTLNTCVPKGIAGFIAESIQGVNGAVQYPKSFLKEAFQLVREREGVCIADEVQTGFGRTGSHFWGFQTHDVVPDIVTMAKGIGNGFPMAAVVTTREIANSLAQNLHFNTFGGNPVACVVGSAVLDAIVEDGLQKNSEEVGTYMLLELAKVRDKFEIIGDVRGKGLMIGIEMVKDKDGCQPLPTEEMNQIWEDCKDMGVLIGKGGIYGQTFRIKPPMCITKQDADFALEVFHAALMRYMERKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYM5</accession>
    <name>A0A151MYM5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004623">
        <property type="protein sequence ID" value="KYO29610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYM5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="7906" checksum="5A65A6FE9A391995" modified="2016-06-08" version="1">MRHVPPWTPPPASSSFEFAVTSPVPPTKTSPAGTISSPSPLSHLACVTFCKERGRQLIHSDVAQALLEHRKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1E0</accession>
    <name>A0A151N1E0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDZ domain-containing protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PDZD9</name>
        <name evidence="2" type="ORF">Y1Q_0008256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1E0"/>
    <dbReference type="STRING" id="8496.A0A151N1E0"/>
    <dbReference type="eggNOG" id="ENOG502RYRV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039179">
        <property type="entry name" value="PDZD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22698">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22698:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="279" mass="30583" checksum="6265A41FFBA76FCE" modified="2016-06-08" version="1">MLKAASRGGGGADVGVGGASSCLCHSHCVTLGLFPALEKISEHTLSTTLKTNISMGEQGLGLIIIQNGPYLQITSLVEKCSAASNGRLKPGDILIKIGHANVLGWTLRELRQLLYNIPVGTSLQIKVYRDFVEVPEHWQSAVELIPEVKLPSNTDTSSKSNEEKEVWSSSDDEVDINLESFRYKSSQSYGYELIEQLPSISRVWHEFKRNHHTFTVGTDIGCDIILHNDVDALCDSGFATTGIKSSSYWTMPKNDDNLSSSSSSLSDAFWLEEFAIVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3A1</accession>
    <name>A0A151N3A1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urotensin-2 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Urotensin II receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">UTS2R</name>
        <name evidence="18" type="ORF">Y1Q_0016565</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3A1"/>
    <dbReference type="STRING" id="8496.A0A151N3A1"/>
    <dbReference type="GeneID" id="102572339"/>
    <dbReference type="KEGG" id="amj:102572339"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001604">
        <property type="term" value="F:urotensin II receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14999">
        <property type="entry name" value="7tmA_UII-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000183">
        <property type="entry name" value="Urotensin-2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000670">
        <property type="entry name" value="Urot_II_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF60">
        <property type="entry name" value="UROTENSIN-2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00647">
        <property type="entry name" value="UROTENSIN2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="71"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO31250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="382" mass="43997" checksum="F1239F051B43DC35" modified="2016-06-08" version="1">MSLNEELENGYSTTTQMATDTSEGSPFRISSNSSYNASWDSTPATNSMEDTIATCTIGTILSLMCVIGVTGNVYTLVVMCHYLRYSASMYIYIINLALADLLYLLTIPFIVGTYFFQEWYFADIGCRILFSLDFLTMHASIFTLTVMSTERYFAVLKPLDTVKRSKSYRKAIAIVIWLVSLLLTLPMLIMIQLVQRDNKSICLPTWSKLSYKIYITILFCTSIVGPGVVIGYLYIRLARTYWVSQTATFKQTKRLPNQKVLYLIFTIVLVFWACFLPFWIWQLLFQYYESFPLSPKAMRNINYLTTCLTYSNSCINPFLYTLLTKNYKEYLRNRQRSFNSSSGYFQRRNRFQRISGRSLSTSSQHCTETYVLAHASLGNNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3R4</accession>
    <name>A0A151N3R4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">GABA(A) receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">GABRD</name>
        <name evidence="24" type="ORF">Y1Q_0006028</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Synaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3R4"/>
    <dbReference type="STRING" id="8496.A0A151N3R4"/>
    <dbReference type="GeneID" id="102560545"/>
    <dbReference type="KEGG" id="amj:102560545"/>
    <dbReference type="CTD" id="2563"/>
    <dbReference type="eggNOG" id="KOG3643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N3R4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19001">
        <property type="entry name" value="LGIC_ECD_GABAAR_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19055">
        <property type="entry name" value="LGIC_TM_GABAAR_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000015">
        <property type="entry name" value="Gamma-aminobutyric acid (GABA-A) receptor, subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000018">
        <property type="entry name" value="Gamma-aminobutyric acid (GABA-A) receptor, subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008098">
        <property type="entry name" value="GABAAd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01722">
        <property type="entry name" value="GABAARDELTA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 21" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022254177" description="Gamma-aminobutyric acid receptor subunit delta" evidence="21">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="22">
        <location>
            <begin position="44"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="255"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO31441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="452" mass="51323" checksum="D9EA4F8B67130778" modified="2016-06-08" version="1">MDLLAWMLPPLVLLCAHQHACSRAMNDIGDYIGSNTEISWLPNLDDLMKGYGRNFRPGIGGPPVNVALAIEVASIDHISEVNMEYTMTVFLHQSWRDDRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLSKYPMDEQECMLDLESYGYSSEDIVYQWSENQEEIHGLDKLQLAQFTITNYRFTTEMMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYVPSILLVAMSWVSFWISQSAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYMKKQKAKMKASRQSGEVNVKNAIVLFSLSIAGVNQELAISNRQHRIPRRFPGSYGPVEVETGETKQQQEMKSDKKGGIKSLFKPIDADTIDIYARAVFPAAFAAVNVIYWVAYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N457</accession>
    <name>A0A151N457_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Adipolin</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Adipose-derived insulin-sensitizing factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Complement C1q tumor necrosis factor-related protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ubiquitin-conjugating enzyme E2 J2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">FAM132A</name>
        <name evidence="26" type="ORF">Y1Q_0006114</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the adipolin/erythroferrone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N457"/>
    <dbReference type="STRING" id="8496.A0A151N457"/>
    <dbReference type="eggNOG" id="ENOG502QQVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046326">
        <property type="term" value="P:positive regulation of D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046628">
        <property type="term" value="P:positive regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000012">
        <property type="entry name" value="Adipolin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000006">
        <property type="entry name" value="Protein FAM132A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052136">
        <property type="entry name" value="Adipolin/Erythroferrone-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019:SF12">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0372">Hormone</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="24">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="25">
        <location>
            <begin position="414"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="277"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO31551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="569" mass="64053" checksum="148F118713200F12" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4E2</accession>
    <name>A0A151N4E2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="7">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">COQ5</name>
        <name evidence="8" type="ORF">Y1Q_0022788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methyltransferase required for the conversion of 2-decaprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="function">
        <text evidence="7">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259203.2">
        <property type="nucleotide sequence ID" value="XM_006259141.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4E2"/>
    <dbReference type="STRING" id="8496.A0A151N4E2"/>
    <dbReference type="GeneID" id="102577348"/>
    <dbReference type="KEGG" id="amj:102577348"/>
    <dbReference type="CTD" id="84274"/>
    <dbReference type="eggNOG" id="KOG1540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000064">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001244">
        <property type="entry name" value="PRK00216.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO31694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="317" mass="35815" checksum="39EE6B0096D98ACF" modified="2016-06-08" version="1">MAASIGAASCRALFCRSWGKRLSAAGRLLGGARGLAAQGETHLGFQTVPEAEKEQRVYQVFESVAKKYDIMNDSMSFGIHRLWKDILLHQMNPYPGTQLLDVAGGTGDIAFRFINYIRSQREYQLRQKLKSHQNLSWQEISKSYQEEALKPLGGSQVVICDINKEMLKVGKQKAQHLGYTEGLSWVVGNAEELPFDDDKFDVYTIAFGIRNVTHIDQALQEAYRVLQPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEIIAGDWKSYQYLVESIRQFPAQEEFKAMIEDAGFLKVEYRNLTAGIVAIHSGFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4E8</accession>
    <name>A0A151N4E8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATOR1 complex protein DEPDC5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DEP domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DEPDC5</name>
        <name evidence="15" type="ORF">Y1Q_0022767</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019349255.1">
        <property type="nucleotide sequence ID" value="XM_019493710.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059569506.1">
        <property type="nucleotide sequence ID" value="XM_059713523.1"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N4E8"/>
    <dbReference type="GeneID" id="102561090"/>
    <dbReference type="CTD" id="9681"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000171">
        <property type="entry name" value="DEP domain-containing protein 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055213">
        <property type="entry name" value="IML1_double_psi_beta_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23013">
        <property type="entry name" value="IML1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="DEP" evidence="14">
        <location>
            <begin position="1189"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="482"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO31660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1604" mass="181760" checksum="C12B280EBE4666EF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N642</accession>
    <name>A0A151N642_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MIS12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MIS12</name>
        <name evidence="11" type="ORF">Y1Q_0007051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N642"/>
    <dbReference type="STRING" id="8496.A0A151N642"/>
    <dbReference type="eggNOG" id="ENOG502RXZ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO32025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="188" mass="22150" checksum="7DFB4E0EB3067413" modified="2016-06-08" version="1">MLRLYIAFQDYLFEVMLVVESVILRKLDSVPNSKIPPLHVRKNTEKFLLFMKKCFDQLFSKMEEVLFQLVLGIPKNALLPEDKVHEQYPYSKEEFQPLQVEIEELQKQYKAEVSAEQKLLAELEEQKIVQTELEKILQWFDGLENVCREHGTSNFKESFAFLTQSSKKLQDVLEEVEKKNNFPKSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6N2</accession>
    <name>A0A151N6N2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WD repeat-containing protein 90</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">WDR90</name>
        <name evidence="18" type="ORF">Y1Q_0020422</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability. Required for efficient primary cilium formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat WDR90/POC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N6N2"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000522">
        <property type="entry name" value="WD repeat domain 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000590">
        <property type="entry name" value="WD repeat domain 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001417">
        <property type="entry name" value="WD repeat domain 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003525">
        <property type="entry name" value="WD repeat domain 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055440">
        <property type="entry name" value="Beta-prop_WDR90_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055441">
        <property type="entry name" value="Beta-prop_WDR90_POC16_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF24">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23393">
        <property type="entry name" value="Beta-prop_WDR90_POC16_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23342">
        <property type="entry name" value="WDR90_beta-prop_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CFA20" evidence="14">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="CFA20" evidence="14">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="711"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="WDR90/POC16 second beta-propeller" evidence="16">
        <location>
            <begin position="722"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="795"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="17">
        <location>
            <begin position="1231"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="1514"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="domain" description="WDR90 4th beta-propeller" evidence="15">
        <location>
            <begin position="1520"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="1606"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1087"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1127"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1129"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO32492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1833" mass="203216" checksum="0F6DC4139A73F490" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7F4</accession>
    <name>A0A151N7F4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003881">
        <property type="protein sequence ID" value="KYO32687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7F4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585807" evidence="1">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="165" mass="17282" checksum="71DBE7FAD7EBB027" modified="2016-06-08" version="1">MLLAALLGLAHAAARLSCLFLLLPLAFACSHLAGRDCYEHGLARGFLPRGVSGLEGERLAMPAARAQLRTPDPGTALPWLVLATLFLALCQGLSCTWLWDAPLQPPAAALLFGPLASELAEALSTFTRLLPALLAASACLLASTLLRAGPRCLETLLFAGLCPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9Z7</accession>
    <name>A0A151N9Z7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor 3B subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor SF3b 155 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Spliceosome-associated protein 155</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SF3B1</name>
        <name evidence="15" type="ORF">Y1Q_0008800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N9Z7"/>
    <dbReference type="KEGG" id="amj:102562721"/>
    <dbReference type="eggNOG" id="KOG0213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N9Z7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000303">
        <property type="entry name" value="splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="13">
        <location>
            <begin position="326"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="14">
        <location>
            <begin position="1083"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1301" mass="145706" checksum="D2F0122F3F7D2DDE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBD3</accession>
    <name>A0A151NBD3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003598">
        <property type="protein sequence ID" value="KYO34122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBD3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11128" checksum="3C491C6B2020F069" modified="2016-06-08" version="1">MGEKIGADFQNGGDLCVPRRSKPRAPGIHLLAPPGGTTDTSQGQEEHMDFRKTGPEEPRASTPAAFSQDVGMINKSAPTDLRVWGCLQGTSNSFRRSYIDVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCN4</accession>
    <name>A0A151NCN4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Junctophilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">JPH2</name>
        <name evidence="13" type="ORF">Y1Q_0021138</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the junctophilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003390">
        <property type="protein sequence ID" value="KYO34572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCN4"/>
    <dbReference type="STRING" id="8496.A0A151NCN4"/>
    <dbReference type="GeneID" id="102576730"/>
    <dbReference type="KEGG" id="amj:102576730"/>
    <dbReference type="CTD" id="57338"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000001">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000003">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000012">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF7">
        <property type="entry name" value="JUNCTOPHILIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037387">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="415"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="542"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="640"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO34572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="761" mass="83477" checksum="86AFF47DCD900228" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDH2</accession>
    <name>A0A151NDH2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0010530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003332">
        <property type="protein sequence ID" value="KYO34790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001872">
        <property type="term" value="F:(1-&gt;3)-beta-D-glucan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071226">
        <property type="term" value="P:cellular response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042808">
        <property type="entry name" value="CLEC7A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="156"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO34790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="271" mass="30611" checksum="EDDE3C2CB991C379" modified="2016-06-08" version="1">MQLPAAPEMGDHLTAYSDMKFDHSKRQKHGDKVVQKEMTMYSELMFQKPSEQKRSTRPQRAEGRGADGKLSPLRRNKDPSVSSLQWRLTAVIFGILCLILLVATGVLGIIVMELSQEKKDPTQCLKSCPDPNRSVPGLPLDQPPDKERYLVRWSHTEKRSYLFSSENRPWAQCNSFCSSHSASLLKIDSQDELAFTKKESFEYSEERGSATYYYPFWXXXXYNSETKTWVWADGTALSPGLINPLVPSHGNDAGGTCVDREQSGLAELQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NE31</accession>
    <name>A0A151NE31_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis 1 arrest protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">M1AP</name>
        <name evidence="2" type="ORF">Y1Q_0016248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003279">
        <property type="protein sequence ID" value="KYO34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NE31"/>
    <dbReference type="STRING" id="8496.A0A151NE31"/>
    <dbReference type="KEGG" id="amj:102565110"/>
    <dbReference type="eggNOG" id="ENOG502QT91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6433824at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051308">
        <property type="term" value="P:male meiosis chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007127">
        <property type="term" value="P:meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033587">
        <property type="entry name" value="M1AP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28642">
        <property type="entry name" value="MEIOSIS 1 ARREST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28642:SF1">
        <property type="entry name" value="MEIOSIS 1 ARREST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="530" mass="58771" checksum="EA8486C935F268CC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEI9</accession>
    <name>A0A151NEI9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEI9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="12037" checksum="EE06D8F84A2CE688" modified="2016-06-08" version="1">MVSMEREEELEDGFRGEEAESLDHVSNHPDIDLEKIIGKNFREEQVAEPAFQQLDIRVKITQLHSSHYELTGWTYINKWNNSADPVLNVNGIQTGYHPGPLYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEK7</accession>
    <name>A0A151NEK7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Rho-associated protein kinase</fullName>
            <ecNumber evidence="30">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="43" type="ORF">Y1Q_0007847</name>
    </gene>
    <organism evidence="43 44">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="43 44" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="43">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="30">Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 30">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="30">Activated by RHOA binding. Inhibited by Y-27632.</text>
    </comment>
    <comment type="subunit">
        <text evidence="30">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Cell projection</location>
            <location evidence="27">Bleb</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 30">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="43">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="30"/>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NEK7"/>
    <dbReference type="KEGG" id="amj:102558298"/>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032059">
        <property type="term" value="C:bleb"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072518">
        <property type="term" value="F:Rho-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20874">
        <property type="entry name" value="C1_ROCK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11639">
        <property type="entry name" value="HR1_ROCK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01242">
        <property type="entry name" value="PH_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22250">
        <property type="entry name" value="ROCK_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05622">
        <property type="entry name" value="STKc_ROCK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000047">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000023">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000036">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.730:FF:000001">
        <property type="entry name" value="rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000033">
        <property type="entry name" value="Rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000072">
        <property type="entry name" value="Rho-associated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001759">
        <property type="entry name" value="Rho-associated, coiled-coil-containing protein kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020684">
        <property type="entry name" value="ROCK1/ROCK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037310">
        <property type="entry name" value="ROCK1_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015008">
        <property type="entry name" value="ROCK_Rho-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF33">
        <property type="entry name" value="RHO-ASSOCIATED PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08912">
        <property type="entry name" value="Rho_Binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037568">
        <property type="entry name" value="Rho_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51859">
        <property type="entry name" value="RHO_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="19 30 34" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="26" id="KW-0966">Cell projection</keyword>
    <keyword evidence="23 33 35" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="25 30" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="22" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="20 30" id="KW-0460">Magnesium</keyword>
    <keyword evidence="24" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 30" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 30 34" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="44" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 30" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 30" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="38">
        <location>
            <begin position="76"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="40">
        <location>
            <begin position="341"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="42">
        <location>
            <begin position="481"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="RhoBD" evidence="41">
        <location>
            <begin position="951"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="37">
        <location>
            <begin position="1122"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="39">
        <location>
            <begin position="1232"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="1325"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="35">
        <location>
            <begin position="427"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="35">
        <location>
            <begin position="940"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="35">
        <location>
            <begin position="1019"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="36">
        <location>
            <begin position="1329"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="31">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="32 34">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00043945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRNR" id="PIRNR037568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PIRSR" id="PIRSR037568-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR037568-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="PROSITE" id="PS51859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="42">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="EMBL" id="KYO35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1377" mass="160634" checksum="A062B478D63CB003" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFU2</accession>
    <name>A0A151NFU2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003146">
        <property type="protein sequence ID" value="KYO35620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFU2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="105" mass="11899" checksum="FA62C9B9C31B76FB" modified="2016-06-08" version="1">MQSGDTWSPRVGENEKVSVGFTFLCVHDCVEAVSRVSPRFYTSSQEMPFSDSFVFYFLIMSNHARRPPGSKADVKKQPGSKTKPAPGRRQQEMHVYPCPQRHVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGH9</accession>
    <name>A0A151NGH9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 8 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GLT8D1</name>
        <name evidence="11" type="ORF">Y1Q_0007591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003049">
        <property type="protein sequence ID" value="KYO35913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGH9"/>
    <dbReference type="STRING" id="8496.A0A151NGH9"/>
    <dbReference type="eggNOG" id="ENOG502QTN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NGH9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06429">
        <property type="entry name" value="GT8_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000069">
        <property type="entry name" value="Glycosyltransferase 8 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO35913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="376" mass="42774" checksum="FFD33B76549BDE77" modified="2016-06-08" version="1">MTFRKVNIFILALAVVIFLLVLHHNFLGLSDFLKRELSDSNALGLQPIDFIPEAPQKLIEKRNEKEIPVVITASEDRLGGIIAAINSIYHNTKSNVVFHIITQNDTVDHLRSWLSNTVLKNVKYQIIDFDPHVLEGKMRVDSEQTDSIKPLTFARFYLPNLLPYSEKAIYVDDDVIVQDDIFELYNTPLKPGHAAAFSDDCDSTTNKFAVRGAGNQYNYIGFLDYKKETIRKLAMKASTCSFNPGVFVANLTEWKLKNITNQLEKWMKLNVVEELYSKTLAGNVATPPLLIVFYKQYSNIDPLWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTASYSDVWEKWYIPDPTGCIQTAAVWSPSAIVTTELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NI60</accession>
    <name>A0A151NI60_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">5' exonuclease Apollo</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
            <ecNumber evidence="6">3.5.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">DNA cross-link repair 1B protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">SNM1 homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">DCLRE1B</name>
        <name evidence="34" type="ORF">Y1Q_0010550</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="30">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EC" id="3.5.2.6" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03002960">
        <property type="protein sequence ID" value="KYO36195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NI60"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14228">
        <property type="entry name" value="STKc_HIPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000003">
        <property type="entry name" value="DNA cross-link repair 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000022">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF43">
        <property type="entry name" value="HOMEODOMAIN-INTERACTING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 31" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="23" id="KW-0234">DNA repair</keyword>
    <keyword evidence="17 34" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 31" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="22" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="33">
        <location>
            <begin position="597"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00039555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00041693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00042738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00061380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="KYO36195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1619" mass="177911" checksum="6513F09A032CE6AC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJA7</accession>
    <name>A0A151NJA7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJA7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO36883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7758" checksum="7EACE002FBB963C9" modified="2016-06-08" version="1">MESSALQSVQFVKERYGESSVKAVVYYCFEFSYGTEKKPQGDQKMSIRKAAPSLLLPTSQILEYQVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK27</accession>
    <name>A0A151NK27_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002826">
        <property type="protein sequence ID" value="KYO37120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK27"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF4">
        <property type="entry name" value="SI:DKEY-5I3.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="21135" checksum="7828866494C1B46F" modified="2016-06-08" version="1">MQAAPAVAPETPAPTGTVLAPTIRLYRLEEGTACPPPTASGPLLLLLPWLGARPRAIARYVALYQQRGMDVLVAETTLCHFLWPRQGLAYAGRVLALLEETPALGARPLLVHALSAGAYAFAQMLVHLSRAPERHGQLAARVRGLVYDSLVTGDLANAALGECGPARWTPGWAGSGGLQPAGDLAARLLCTHTCMCACTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK48</accession>
    <name>A0A151NK48_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Synaptotagmin-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Synaptotagmin V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Y1Q_0008442</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Interacts with both alpha- and beta-tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Recycling endosome membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK48"/>
    <dbReference type="STRING" id="8496.A0A151NK48"/>
    <dbReference type="eggNOG" id="KOG1028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21342">
        <property type="entry name" value="Syt1_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000007">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000111">
        <property type="entry name" value="synaptotagmin-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF282">
        <property type="entry name" value="SYNAPTOTAGMIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="170"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="301"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO37168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="451" mass="50317" checksum="38A079FB78A57529" modified="2016-06-08" version="1">MPGFSPSSLKGIEEGEFAPAPARGPCCGAGPQQGAEMNAARRSAMLATEGPAPQLQGTRNTTQVPTRENFSNMKDKFMNKISKLPIPPWALATILIVAGLLLLCCCVCLCKKCLGRKRKGKKGKDKVKAQINMKEVKDLGKSYIDKVQPDIEDLDPALLQEPKEEKPQEKLGKLQYSLDYDFQNGQLVVGIVQAADLPALDLGGTSDPYVKVFLLPEKKKKHETKVHRKTLNPIFHEAFTFKIPYAELGGRTLVMAVYDFDRFSKHDAIGEVRVPMSSVDLAHIIEEWRDLQSPEKEEHEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKIHLMQAGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVLTVLDYDKLGKNEAIGKVFVGCNATGTELRHWSDMLANPRRPIAQWHTLQTEEEVDAALGIKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLV8</accession>
    <name>A0A151NLV8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002570">
        <property type="protein sequence ID" value="KYO37812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLV8"/>
    <dbReference type="STRING" id="8496.A0A151NLV8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="1">
        <location>
            <begin position="128"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="217" mass="25194" checksum="517AD83A3A71E210" modified="2016-06-08" version="1">MAAYANTQPVPMTAVDLLGQNLQALTQIVNSQQQMFDRQEEWLRRSQVSFKMPKMMKDDDPEAYIETFERHALMTGLPQDYWASQLGALVVGAAQAAYRAIPREEARDYEQVKQAILYRLEISPDHYRRLFRARKGPDERRPRVLLQLLRDLLNKWVNPVGSDHEDLADQVILEQFQNDLEERTHSWVRQHSPRNCEEVLKLAEAFAVVEGIGLHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NM18</accession>
    <name>A0A151NM18_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002566">
        <property type="protein sequence ID" value="KYO37861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NM18"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="12838" checksum="C8C7086DD942B4B0" modified="2016-06-08" version="1">MWICSVLCKSVSSCTILDSLMLAVSEHGPLLRNFSLDYVIPCACRSFGSALSKISSGPSDGSDHEMGASVMLNIILHFCKVSAMSKNEEEEEMMAVRCTTQDHMKVVRTSANVGFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNZ1</accession>
    <name>A0A151NNZ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0020707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002521">
        <property type="protein sequence ID" value="KYO38493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNZ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO38493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="150" mass="16983" checksum="41C1F3FEF2AAE6CE" modified="2016-06-08" version="1">MAPMLPRPAVPLDPEYEGSEGARRKQLKEEMLEELVAASTRRARAAEEWRARVEFHQERCADLVSRGITHARRAARRQERKISAAMREAAAAAREVMELLRENLDFEREMQRSMLGLLSRQTACIEAALQRPFPGACHGAGEPPRHTMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP66</accession>
    <name>A0A151NP66_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Connector enhancer of kinase suppressor of ras 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CNKSR2</name>
        <name evidence="5" type="ORF">Y1Q_0015682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNKSR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP66"/>
    <dbReference type="STRING" id="8496.A0A151NP66"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06748">
        <property type="entry name" value="PDZ_CNK1_2_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000060">
        <property type="entry name" value="Connector enhancer of kinase suppressor of Ras 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017874">
        <property type="entry name" value="CRIC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF12">
        <property type="entry name" value="CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10534">
        <property type="entry name" value="CRIC_ras_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51290">
        <property type="entry name" value="CRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="CRIC" evidence="4">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="196"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO38439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="326" mass="36791" checksum="6BC3E54DC8B3CEED" modified="2016-06-08" version="1">MPRLDDCLQQYIKNFEREKINGEQLLHITHQELEELGVTRIGHQELILEAVDLLCALNYGLETENLRTLSHKLNASAKNLQNFITGRRRSGHYDGRASRRLPNDFLTSVVDLIGAAKNLLAWLDRSPFVSVTEYSLLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLSGICDHIISLSSDSLVSQSAHLEVVHLTSIMPSEGLGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPNGVILTLKKRPQNTLVSAPALLKNVRWKPLALQSSCMHQNAGRYRQVWKRELKQLRCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPG0</accession>
    <name>A0A151NPG0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box/LRR-repeat protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FBXL13</name>
        <name evidence="2" type="ORF">Y1Q_0023376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPG0"/>
    <dbReference type="STRING" id="8496.A0A151NPG0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="221"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="381" mass="44928" checksum="27B244CFFD5E6E77" modified="2016-06-08" version="1">MLPARASDIPALSPIGSQAVPEEDPLKFLEEKIREIMEKGLDGILWDMCIDPSLKLELKRISETYLHIIFGLNDKQLMTEELCGKAWNFHTRNLKNMCFQAWMQYCLLKKEARRDAEQNMALAAVHYNSRIIKVIVQKWSGWVRFHKEQMALAVRKIQWVFNVKLLRIILKAWHAEAQSSAKTKAYFEQLEKEDQEESFDLHHCFSLELIKEKTATSRIVNYEKSNLPERTLLQIFHYTDLIDLARCAQVSRTWMSVTQNSSLWSDIDFSAVKHKIQDKTVVNILQKWRTYVLRLNLRGCSSLHWPSFKSIGLWQTWKAKVNHMWAWMQCLHYVLKSVTAHRLRNTALEQIDIEEDHAQQQENEVELQNWLSYESRLKQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPW6</accession>
    <name>A0A151NPW6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002432">
        <property type="protein sequence ID" value="KYO38882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPW6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="9610" checksum="1387B5BAD30B2C1D" modified="2016-06-08" version="1">MLWWEKLPPVRLRSSNLAPDACLGADGWAKRILPPIKGSSCVPSVGQVQERRDPAPGATPGQDSDEHTNRGSPLSKRTGAQGEAETPLPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQY8</accession>
    <name>A0A151NQY8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPN-loop GTPase</fullName>
            <ecNumber evidence="11">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GPN1</name>
        <name evidence="14" type="ORF">Y1Q_0016966</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer with GPN3. Binds to RNA polymerase II (RNAPII). Interacts directly with RNAPII subunits RPB4 and RPB7 and the CTD of RPB1. Interacts with XPA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03002334">
        <property type="protein sequence ID" value="KYO39272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273651.1">
        <property type="nucleotide sequence ID" value="XM_006273589.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQY8"/>
    <dbReference type="STRING" id="8496.A0A151NQY8"/>
    <dbReference type="GeneID" id="102559035"/>
    <dbReference type="KEGG" id="amj:102559035"/>
    <dbReference type="CTD" id="11321"/>
    <dbReference type="eggNOG" id="KOG1532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000696">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO39272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="379" mass="42167" checksum="EB4A6978E79D0A4D" modified="2016-06-08" version="1">MAAAAAVGEVAAGGPEPPVCVLVLGMAGSGKTTLVQRLVAHLHGQGAPPYVINLDPAVHELPFPANIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKRQNTSKYVLIDTPGQIEVFTWSASGTIITEALASSFPSVVVYVMDTSRSTSPITFMSNMLYACSILYKTKLPFIVAMNKTDIIDHSFAVEWMQDFETFQDALNQETTYVSNLTRSMSLVLDEFYSSLKVVGVSAVLGTGLDEFFVQVSKAVEEYEREYRPEYERLRKKLEKAQSKQQKEQLERLRKDMGPVSVESTSLAGPADTSAMGPSDLILTRGTLDDEEEDSDTDDIDHQVTEERHEEPAFKNFMQETRMKYHKKCARGVGDIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NR43</accession>
    <name>A0A151NR43_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tubulin monoglycylase TTLL3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TTLL3</name>
        <name evidence="10" type="ORF">Y1Q_0017327</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamyl-[protein] + glycine + ATP = glycyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:17207"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:167890"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67181"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002304">
        <property type="protein sequence ID" value="KYO39316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NR43"/>
    <dbReference type="STRING" id="8496.A0A151NR43"/>
    <dbReference type="eggNOG" id="KOG1876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000032">
        <property type="entry name" value="tubulin monoglycylase TTLL3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF2">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO39316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="452" mass="51179" checksum="429BB8D65348D9B1" modified="2016-06-08" version="1">MNHYARAGSFTTKVGLCLNLRNLPWFDQADADTFFPRCYRLGAEDDKQAFIEDFRLTAARSLLKVVLSRAGGPLAREAGANSTHEGPPEASTSPVSLRGAARRRGSPLPRRLVEMALQACEEHLNSLQHQDIDKAAELAPARADARWEEFLRGYYCMVHEGAPLELSPAHAEQCQDMLQQLQELLPQLEMEGDHNIWIVKPGAKSRGRGIVCMARLEEMLRLVNCDPIVVKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTIWFYRDSYLRFSTQPFSLHNLDAAVHLCNNSIQKHYEASLQRHPRLPPGNMWSSQQFQEHLQQAGAGAAWQDVMVPGMKAAIIHAVQSAQDVVELRKGSFELYGADFIFGEDFKPWLLEVNASPTMAASTAVTSRLCAGVQADTLRVVIDRRHDRTCPTGAFELIYKQAAVDVPQRRKKRDRPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NR93</accession>
    <name>A0A151NR93_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TNF receptor-associated factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0008573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002254">
        <property type="protein sequence ID" value="KYO39366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NR93"/>
    <dbReference type="STRING" id="8496.A0A151NR93"/>
    <dbReference type="eggNOG" id="KOG0297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000001">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF96">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MATH" evidence="6">
        <location>
            <begin position="180"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO39366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="331" mass="36477" checksum="C61C90FDCCD12AEE" modified="2016-06-08" version="1">MGDMSSMVFSPWSSSETLTTPQGGAAGAPAPYEEETPPCGCYQALRRDLLGPEGYRAPVQPLFNDLDRVHHGPLEAHAALLPGREGAPGASDLLGPLEQRLGRVELQQKTLHNILAVMSRELSRREEPGAAASEALGEALARILQLEEKVAHQDSLLAIKDVMISSLGARIQTLEQTSYDGRFLWKVTDITLRRREAQTGQRLALYSPSFYTHRYGYKLCLKLFLNGDGAGAGTHLSLFLVVMRGEYDFQLQWPFQHKVTFSLLDQSGQRHVSTSFRPLGTSSSFQRPVGKNNIASGLPEFFPLRQLEAPSGATYLQEDTLVFQALIDPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRV6</accession>
    <name>A0A151NRV6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase 1 domain-containing protein 1 isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GLT1D1-1</name>
        <name evidence="3" type="ORF">Y1Q_0018662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRV6"/>
    <dbReference type="STRING" id="8496.A0A151NRV6"/>
    <dbReference type="eggNOG" id="ENOG502QQZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052622">
        <property type="entry name" value="Glycosyltransferase_G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46660:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="191"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO39591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="358" mass="40284" checksum="9477E5E051949DAC" modified="2016-06-08" version="1">MRLLLVACLRPRTGNATTAARIREKNELESRSSLEEKNRTDHLEAAGHTCILKDAFRYEGPSEIANLISAEKYEAALAIHLYKGGRLLQGSSIPFGIIFGGTDINEDIKHEEKHRVMGAVLEEARFAVAFTEKMKEMAESEWPYAGNKICVQTQGIMTTPSTTFNWKRFLQNAGIPQDTDNLCLFILICGLRRIKDPLYLVDVFSEWHRKEPNVHLAIIGPTVDPLFVSEVKEKIKRSPGVHLLQEIPQDDLHAAVKRCFAVVNSSISEGMSAAVLEAMDLDVPVLARNIPGNAAIIKHKDTGLLFADPQEFVLLSKSLMNDPTLEKKIVTRAKDYVKKHHSWECERKTYQSLILRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NS41</accession>
    <name>A0A151NS41_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Platelet glycoprotein Ib alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GP1BA</name>
        <name evidence="5" type="ORF">Y1Q_0011099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002333">
        <property type="protein sequence ID" value="KYO39275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NS41"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000732">
        <property type="entry name" value="GD11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF157">
        <property type="entry name" value="LRRCT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LRRCT" evidence="4">
        <location>
            <begin position="202"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO39275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="311" mass="34417" checksum="3819AFE0FCCEF15B" modified="2016-06-08" version="1">MEMNQIKDRNQANCTRLGLSRVPSQLPKDTGILLLGCNHLVSVSTSSFQYLPMLVDLDLSHNGLKAFHAAPALPRLQELILSHNALGALXXXXGLPGLLHLGLAHNSIQDLAPGAFRSLGELQELDLRGNQLRRLPKEAFAGLAELRNLDLSNNSLEELPLGLLSELEALEGLRLSGNYLRTMPTGFFPEDRILHYVFLDKNPXXXNCSLAYLRDWITENEASVYYQEDGLDAVKVENDAESARCDSPAQYRGTPVLYFTQSCSKVGNGDVYVPETRPDDLPVLHTSVPSTTMATASSRCDSFLLFWIWCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NS67</accession>
    <name>A0A151NS67_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Natural cytotoxicity triggering receptor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0004661</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002316">
        <property type="protein sequence ID" value="KYO39305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NS67"/>
    <dbReference type="STRING" id="8496.A0A151NS67"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002429">
        <property type="term" value="P:immune response-activating cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030101">
        <property type="term" value="P:natural killer cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045954">
        <property type="term" value="P:positive regulation of natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043226">
        <property type="entry name" value="NCR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47904">
        <property type="entry name" value="NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47904:SF1">
        <property type="entry name" value="NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586331" description="Natural cytotoxicity triggering receptor 3" evidence="14">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO39305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22838" checksum="679A5FAD3C824E56" modified="2016-06-08" version="1">MALGTLLGIGTLLTGSWSQELWGPQVGSYRWEKEPGLKVAPGVLPFQGRLGVPEARVFLEEGRADLEIHDLRHYDAGTYRCLVTLHGAPEAAGNGTQLHVDRPGAGPGQGSDQPTVLLVLLVRALLYVLGIIMAALGSSLYYQRQVLQNRQRLKLQSQQEPREPRRPGSQPHHRCNSASPYSLLRAGRDPRCPGSQPHPLQPTTLHSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NS85</accession>
    <name>A0A151NS85_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NS85"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7606" checksum="8D9C69FF447943EC" modified="2016-06-08" version="1">MRTGIATGIRVQLERAWGLIPPSSLRLLDQSSRTHERDETRPQPGLLRTYSQKLEMKEDRVCVKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSV4</accession>
    <name>A0A151NSV4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 34A isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ANKRD34A</name>
        <name evidence="6" type="ORF">Y1Q_0004456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKRD34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002142">
        <property type="protein sequence ID" value="KYO39951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059574806.1">
        <property type="nucleotide sequence ID" value="XM_059718823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSV4"/>
    <dbReference type="STRING" id="8496.A0A151NSV4"/>
    <dbReference type="GeneID" id="102558772"/>
    <dbReference type="CTD" id="284615"/>
    <dbReference type="eggNOG" id="ENOG502QT4A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NSV4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042637">
        <property type="entry name" value="AN34A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156:SF4">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 34A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO39951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="522" mass="56421" checksum="E59FE63FE8513943" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSZ0</accession>
    <name>A0A151NSZ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acidic repeat-containing protein isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ACRC-1</name>
        <name evidence="2" type="ORF">Y1Q_0006669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002120">
        <property type="protein sequence ID" value="KYO39977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSZ0"/>
    <dbReference type="STRING" id="8496.A0A151NSZ0"/>
    <dbReference type="eggNOG" id="KOG3854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="283"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="498" mass="57361" checksum="1B49083653B3AE87" modified="2016-06-08" version="1">MKTPKSLAHQVPKKQNDSLSDFIVDSREDFFSDFKRKEGTMLKDVWAREKPVARGKENACYREQLRLEFLSDSDTEDSVFIKSTWRDRHQKSGEKGLKKNLRRTKQPPSHIQKDLAFSKYNLSPSLDEKEQGCEGESTEDKIQTLVLQQNAMVESDISEDEFESLIERVKKRSTPLTPSLPMNKTTVCQPATKELENFRSSCESIQQTVQRERIQRQNSESLLKDASSSSVPCTRLLEIQSVNCMHPSLSEKRSNLCPVPGCFLQDLSKPTSQYVKDFRRKKEVLTEELYSLYNSTIFEQKLPEKMEIIWNKKMRKTAGYCVTGQTKGPELQRYARIELSEKVCDSADRLRDTLIHEVCHAATWIINGIRDGHGPIWRFYAKKSTVIHPELPMVTRCHSYEIKYKFTYECSVCKATIGRHSKSLDTERFVCAHCRGQLVLCQSSRKDGTPVRTQLTPFAKYVKENYGSTKKKQHALSHAEVMRKLSADFASKTRLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTC5</accession>
    <name>A0A151NTC5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinetochore-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KNTC1</name>
        <name evidence="6" type="ORF">Y1Q_0018750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NTC5"/>
    <dbReference type="GeneID" id="102574168"/>
    <dbReference type="KEGG" id="amj:102574168"/>
    <dbReference type="CTD" id="9735"/>
    <dbReference type="eggNOG" id="KOG4256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343783at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055404">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055405">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055402">
        <property type="entry name" value="KNTC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019527">
        <property type="entry name" value="RZZ-complex_KNTC1/ROD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24516">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24515">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24506">
        <property type="entry name" value="KNTC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10493">
        <property type="entry name" value="Rod_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="5">
        <location>
            <begin position="400"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 second ARM-repeats" evidence="4">
        <location>
            <begin position="755"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 third ARM-repeats" evidence="3">
        <location>
            <begin position="1335"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="domain" description="RZZ complex subunit KNTC1/ROD C-terminal" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="2137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO39715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2218" mass="251666" checksum="4AAE23E40201D15F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUK8</accession>
    <name>A0A151NUK8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 526-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0007724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001959">
        <property type="protein sequence ID" value="KYO40340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUK8"/>
    <dbReference type="KEGG" id="amj:102576624"/>
    <dbReference type="eggNOG" id="ENOG502SJZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9427046at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO40340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="314" mass="32742" checksum="DD250938409D1502" modified="2016-06-08" version="1">MRERGRPPPSPRPHCACAARAPAAGRDRVPPTGPEQPPYGIVGYSQHSALSGGEAPGMMSEAHRHGDVAGSEDASFEEEDGTSTGISTMQEDDESEATSVSSGESSPPTPSANGYPGPRSKVAGEAPTDMGADAGEERLGAPSPEWHECPECGRGFGTSRALKVHRSYHVGRKRPHGTAPSPKPPGVARPAPPLPSLSDADTRPAPRPGAFHYICAECGLGFASPASLEAHRCEHGWRRSPPAPPLPPSLAPRSAKAPPPPLPPRQANGAPPPPPPPPEPEGADGPYQCTECPGEFGLVSDLHEHYMLHARGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW85</accession>
    <name>A0A151NW85_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger BED domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZBED1</name>
        <name evidence="9" type="ORF">Y1Q_0022543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001669">
        <property type="protein sequence ID" value="KYO41137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014455921.1">
        <property type="nucleotide sequence ID" value="XM_014600435.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340969.1">
        <property type="nucleotide sequence ID" value="XM_019485424.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NW85"/>
    <dbReference type="GeneID" id="106737305"/>
    <dbReference type="KEGG" id="amj:106737305"/>
    <dbReference type="CTD" id="9189"/>
    <dbReference type="eggNOG" id="KOG1121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF2">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE ZBED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO41137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="695" mass="79581" checksum="C5E04CAD3C556181" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXN4</accession>
    <name>A0A151NXN4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras GTPase-activating protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GAP1(IP4BP)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ins P4-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0006184</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXN4"/>
    <dbReference type="STRING" id="8496.A0A151NXN4"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08401">
        <property type="entry name" value="C2A_RasA2_RasA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04010">
        <property type="entry name" value="C2B_RasA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13371">
        <property type="entry name" value="PH_GAP1_mammal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05134">
        <property type="entry name" value="RasGAP_RASA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000011">
        <property type="entry name" value="Ras GTPase-activating protein 2 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000144">
        <property type="entry name" value="Ras GTPase-activating protein 2 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000086">
        <property type="entry name" value="Ras GTPase-activating protein 2 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000144">
        <property type="entry name" value="RAS p21 protein activator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037774">
        <property type="entry name" value="RASA3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF53">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00402">
        <property type="entry name" value="TECBTKDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00107">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="123"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="14">
        <location>
            <begin position="331"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="577"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO41349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="838" mass="96557" checksum="12B1D4A2AA3BFE93" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXP1</accession>
    <name>A0A151NXP1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXP1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="137" mass="15214" checksum="649D0D7E415B4C7A" modified="2016-06-08" version="1">MNEPQFGGSIAPVKDELRSRLSPAQMARWLKDYLSFGSRRSPPQPPKPDYSESDILKAYRAQKSLDFEDPYEDRCNTEPNPGGSPNKVAVGAGSEGGKFPSPKHRLIKVESADLNRSRALLATADEELTGRREQELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY50</accession>
    <name>A0A151NY50_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001603">
        <property type="protein sequence ID" value="KYO41797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY50"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO41797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="115" mass="12294" checksum="D023C51BBE62D7CC" modified="2016-06-08" version="1">MREDGRSPIQRTPLQPWQRLCLHLWLGVRGVWGQKGAEELSWGMNSAAAQGNVSYGDSTSLIWSALPIFHESCSVPRSPAPGLSPSLRLLSACTCPAAGEIGSQDPQQPALPGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYQ5</accession>
    <name>A0A151NYQ5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0022521</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001509">
        <property type="protein sequence ID" value="KYO41928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYQ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000620">
        <property type="entry name" value="Zinc finger protein 263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000087">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000933">
        <property type="entry name" value="zinc finger protein 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001630">
        <property type="entry name" value="Zinc finger protein 888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO41928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="213" mass="24652" checksum="F5FA236486DB667E" modified="2016-06-08" version="1">MDFLRSEKDQWPKSQQRPSKKKENVAVNQVPSSVGRESGEGTEARKSPGCRKEFGEQPSNLARHRCMHAGEKPHQCFECGKSFIQSFNLVEHQHIHTGEKPHQCWECGKSFTCFSNLAWHQLIHTGEKPYQSSEYGKSFTYSSHLARHQFIHRGKKLHQCLECGKGFTRFSNLARHQLIHTREKPHQCSECGKSFGHSSYLVQHQHIHTREHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZC3</accession>
    <name>A0A151NZC3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 12">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">AHCY</name>
        <name evidence="15" type="ORF">Y1Q_0002855</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine. Binds copper ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21709"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="11 12">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 12"/>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019340219.1">
        <property type="nucleotide sequence ID" value="XM_019484674.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZC3"/>
    <dbReference type="STRING" id="8496.A0A151NZC3"/>
    <dbReference type="GeneID" id="102571289"/>
    <dbReference type="KEGG" id="amj:102571289"/>
    <dbReference type="CTD" id="191"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NZC3"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000007">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="4 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="14">
        <location>
            <begin position="192"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="223"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO42241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="433" mass="47851" checksum="F24D887CD7DCAAAE" modified="2016-06-08" version="1">MSDKLPYKVADISLAEWGRKAIEIAENEMPGLMKMREMYGASKPLKGARIAGCLHMTVQTAVLIETLVVLGAEVQWSSCNIFSTQDHAASAIAKTGIPVFAWKGETDEEYLWCIEQTLYFKDGQPLNMILDDGGDLTNLVHTKYPQLLKGIKGISEETTTGVHNLYKMKANGTLKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAIVAGYGDVGKGCAQALRSFGARVIITEIDPINALQATMEGYEVTTMEEACKEGNIFVTTTGCTDIVQSRHFEQMKDDAIVCNIGHFDVEVDVKWLNENSVEKVNVKPQVDRYKLKNGHHIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVLAQIELWTNNDQYPVGVHFLPKKLDEAVAAAHLDKLCVKLTKLSDKQAKYLGVSKEGPFKPEHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZW1</accession>
    <name>A0A151NZW1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal protein of 55 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CEP55</name>
        <name evidence="11" type="ORF">Y1Q_0022168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
            <location evidence="2">Midbody ring</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZW1"/>
    <dbReference type="STRING" id="8496.A0A151NZW1"/>
    <dbReference type="eggNOG" id="ENOG502QTDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1180:FF:000002">
        <property type="entry name" value="Centrosomal protein of 55 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1180">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038926">
        <property type="entry name" value="CEP55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022008">
        <property type="entry name" value="EABR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31838">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 55 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31838:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 55 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12180">
        <property type="entry name" value="EABR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSG101 and ALIX binding" evidence="10">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="199"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO42304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="425" mass="49888" checksum="BEC7E904D5FDF3AC" modified="2016-06-08" version="1">MEEILKGKGKMTDAERNRLLEKIFSLETDKEKYICALGEKENEIQSLKEKFKSRSKSSDVASLLSQLEEKTKEAETREQLLNSLSEEMDRLKQNLTTVNAKCSELENRASTFQLSQEAVTNFPGSPTDFGELEKQLKDALEKNHQWLIYDQQREAYVRGLLARIFELEKQSEMVSQQQAKDAGAEGYLQEKQKYYDQLLLTAKKDLETERQTVTQLKSERNEFKHKYEETKREVLSLNLQLSQRNFEMQTLEEENKIKEDKIHRLKQENEVIREHLNKEKRISEDLLSQVQLLHKSLFKQQEEHKRIASLEQQIQMCITDFENEKFDRQNLQHQLNKVFKELLKAKETSKIRVFGNVEPAEDGLQTAFQDKLTIYDKNTSLKRLNLLDESFLECPKCKAYKNRGIPVLDQIMRSHLIGILSDFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P145</accession>
    <name>A0A151P145_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001382">
        <property type="protein sequence ID" value="KYO42630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P145"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="125" mass="14632" checksum="B1A0B7E2D907EB98" modified="2016-06-08" version="1">MRRLRREQDARRDRIQEELLRAERARLREAQAFRQQVLAELRHFRRDQALAQEEAQAGRVALQQLVAEIRQEQQLAQDSYEELRQLRASINTAVQEERRVETGLELRVLGRDHGTVKASGVGFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2A8</accession>
    <name>A0A151P2A8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2A8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="82" mass="9544" checksum="7D05915E23B44226" modified="2016-06-08" version="1">MQQVEEHLIPGMLMKLKHHLEKHLFHGSSAELFKFICYNHLEPDFSGLHKPTYDKGCYFYSLQAIPITLPCQQGRVMLCIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2S1</accession>
    <name>A0A151P2S1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="5">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0007230</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:19897"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19898"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03001207">
        <property type="protein sequence ID" value="KYO43364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2S1"/>
    <dbReference type="STRING" id="8496.A0A151P2S1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase (NOS)" evidence="15">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO43364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="211" mass="23151" checksum="68C1669BD19DF57F" modified="2016-06-08" version="1">MGNLQAVLPESARTCGLSFCSRQPCAPPDDSAPSDKGSTAPSRPSEPPRYARIKNWQTGSISYDTLSAQACQELPCSGQRCLGSVMFPKQLVCAAGQGPYPKDELRPLARDFLHQYYSSIKRLPILPTCPVLGAARVGARVLGQIQAVAPDRADSPAHVQRLMEVEQEIEATGTYQLLEPELIFGAKQAWRNAARCLGRIQWNKLQVRMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6I5</accession>
    <name>A0A151P6I5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain family 4 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CLEC4A</name>
        <name evidence="4" type="ORF">Y1Q_0010471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000695">
        <property type="protein sequence ID" value="KYO44664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6I5"/>
    <dbReference type="STRING" id="8496.A0A151P6I5"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="75"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="240"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO44664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="370" mass="42637" checksum="B6D96B63DC2372B2" modified="2016-06-08" version="1">MALEITYAEVKFKDTLLPVEAKAPPEKSTPQREPCKPKLWVPWLVSALLLLLCVALIITLIEQFWTCCPMGWKPFRANCYYLSSDSMSWDESEKNCTGMGSHLVVINTQAEQDFLLSWTKTIFSSRRSYFIGLSAQEVEAQWCWVDQTPYNKTATFWKPGEPSSPKTEQCTSFQMGHHAHIRVIFLSQWPCNCKLKVMLHKQSPKAHKLPETFPEWRCALGTPGSKEWVWTCCPMGWKPFRVNCYYLSSDSMSGDESEKNCTGMGSHLVVINTQAEQDFLLNWTKDIFSSRRTYFIGLSAQEVEAQWRWVDQTPYNKTAAFWKPGEPRIPKMEKYTSFQVHSRTQARQNWNDIPCSTSLNRICEAAAAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6N1</accession>
    <name>A0A151P6N1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-AMP-activated protein kinase subunit gamma-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PRKAG1</name>
        <name evidence="16" type="ORF">Y1Q_0016628</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000816">
        <property type="protein sequence ID" value="KYO44385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019338040.1">
        <property type="nucleotide sequence ID" value="XM_019482495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6N1"/>
    <dbReference type="STRING" id="8496.A0A151P6N1"/>
    <dbReference type="GeneID" id="102574506"/>
    <dbReference type="CTD" id="5571"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P6N1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000003">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000004">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF38">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0129">CBS domain</keyword>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="125"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="272"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO44385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="330" mass="37212" checksum="0911FE979EC550DA" modified="2016-06-08" version="1">MEGAVPESVAEKGSPAPEGEDAESNDGVYTCFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIHNKIHRLPVIDPDSGNTLYILTHKRILKFLKLFITEVPKPEFMSKTLEELQIGTYSNIAMVRTTTPIYVALGIFVQNRVSALPVVDESGRVVDIYSKFDVINLAAEKTYNNLDVTVTRALQHRSQYFEGVLKCYKHETLETIINRLVEAEVHRLVVVDEQDVVKGIVSLSDILQALMLPGGPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8X5</accession>
    <name>A0A151P8X5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Macrophage mannose receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000586">
        <property type="protein sequence ID" value="KYO45359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8X5"/>
    <dbReference type="KEGG" id="amj:102576896"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015721">
        <property type="term" value="P:bile acid and bile salt transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052678">
        <property type="entry name" value="OST-beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36129:SF1">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36129">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24562">
        <property type="entry name" value="CysR_MRC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="197" mass="21200" checksum="B5A1BD6077B33BA3" modified="2016-06-08" version="1">MKGTMEQAQMQDQQLLETASSPFMIYNKNHQLCVEVEAGKSLTAATCHPPSPTKLFRWVLGGRLLHVGSGSCVGVAQSASQRAVRLEPCDAQRPQQHWVCGEGGLLGLAGVTPPLYFNYGNSIRSVVMLYTGNKEWSRWVVYDSHRDLCSRACDGEFQAPAMSSQPQATAVPSTACAGPQTGCLGLGRPQDSAVGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAH8</accession>
    <name>A0A151PAH8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable tRNA methyltransferase 9B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Probable tRNA methyltransferase 9-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0021617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May modify wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAH8"/>
    <dbReference type="STRING" id="8496.A0A151PAH8"/>
    <dbReference type="eggNOG" id="KOG1331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000154">
        <property type="entry name" value="Probable tRNA methyltransferase 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF36">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 9B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO46033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="477" mass="54294" checksum="67F219F831DD7DC5" modified="2016-06-08" version="1">MDFVGQQPNNSEQEIWMEHEATQLEKQHVHSVYESTASYFNDLQSKAWPRVRQFLLEQKPGSLIADIGCGTGKYLAVNSQVYNLGCDYCGPLVEISKKKDCEVLVCDNLNLPFRDQCFNTIISIGVIHHFSTKQRRIKAIKEMARVLMPGGQMMIYVWAMEQKNRRFEKQDVFVPWNRALCSRPFSESNQTGDKNELNAKNQDIHLQQFTGSECAYAVNPKLDFDSKHSHSTDHCLPGTCCMKMSEEENRFYRALGRSFRLWFFSRSLDESALRKQPEKVKQEKNIGRWTNSAISIQPSRHCSLDLGHPGPLLKERSLDDDEVFLESVSLGKAQWMAASNATRDLSGEQDIQSKHEETSSLSGLMEDKDCSCTCKKDEGDKSPASKLFKRTSTTDSTDSILDAAVTVGDQTTGTLDTKAFMRYYHVFREGELCCLVEENVHELQILSSCYDHGNWCIIAEKLGKSLQTEQHKNFKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAV6</accession>
    <name>A0A151PAV6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Y1Q_0021676</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+)(in) = H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAV6"/>
    <dbReference type="STRING" id="8496.A0A151PAV6"/>
    <dbReference type="KEGG" id="amj:102576169"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PAV6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000002">
        <property type="entry name" value="Putative ADP/ATP translocase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF32">
        <property type="entry name" value="ADP_ATP TRANSLOCASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="7 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="212"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO46110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="298" mass="33064" checksum="BA7CBDCCF95CDF4D" modified="2016-06-08" version="1">MSDQALSFLKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQITVEKQYKGIIDCVVRIPKEQGIISFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGLSEREFTGLGNCIAKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKGMMPDPKNVHIIVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYKGTIDCWKKIAKDEGPRAFFKGAWSNVLRGMGGAFVLVLYDEIKKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDC7</accession>
    <name>A0A151PDC7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO47043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDC7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="153" mass="16551" checksum="30812E28AFA33DCF" modified="2016-06-08" version="1">MQPEAGPDLVEGSNRSEASGIGQHGYAELCQKSMRYLPTFVICIPSESHLLILQSLPAESKMACITSSSDFGFLLPPRNSAKCSKDFANSLTSKALELASDATAVNRASGLQAKCTLNLVGLEQDCSYLPPRRLGVSSSSMQRSVPFRWSEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PED2</accession>
    <name>A0A151PED2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-associated progesterone receptor component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PGRMC2</name>
        <name evidence="5" type="ORF">Y1Q_0001179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274062.2">
        <property type="nucleotide sequence ID" value="XM_006274000.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PED2"/>
    <dbReference type="STRING" id="8496.A0A151PED2"/>
    <dbReference type="GeneID" id="102561427"/>
    <dbReference type="KEGG" id="amj:102561427"/>
    <dbReference type="CTD" id="10424"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PED2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF24">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="86"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO47362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="206" mass="22555" checksum="838BA857B6707429" modified="2016-06-08" version="1">MMADDGDGQLRTEGSDGLGAAGAEEETAAGEGWVAGGEMLLSVGLLALALLAAYGLYVRWGRRSGPGAAAQQNQAAAVPRMKRRDFTLEQLREFDGARKPNILLAVNGKVFDVTNGSKFYGPEGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHTKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PG16</accession>
    <name>A0A151PG16_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ectonucleotide pyrophosphatase/phosphodiesterase family member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000310">
        <property type="protein sequence ID" value="KYO47932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PG16"/>
    <dbReference type="STRING" id="8496.A0A151PG16"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF63">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586995" description="Ectonucleotide pyrophosphatase/phosphodiesterase family member 7" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO47932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9088" checksum="338538FFE80A3310" modified="2016-06-08" version="1">MLLSLALLLAALALGTGAPLPNGHNRSKLLLVSFDGFRWNYDHDVDTPNLDAMAQEGVKARYMTPAFVTITSPCHFTLVTGECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PI79</accession>
    <name>A0A151PI79_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Rho guanine nucleotide exchange factor 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0004004</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PI79"/>
    <dbReference type="eggNOG" id="KOG3520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000004">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000021">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF22">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="667"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="12">
        <location>
            <begin position="862"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="1100"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="771"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1494"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO48594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1685" mass="192215" checksum="84F9C7DCA600A305" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ34</accession>
    <name>A0A151PJ34_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Erythrocyte membrane protein band 4.1-like 4A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein NBL4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EPB41L4A</name>
        <name evidence="8" type="ORF">Y1Q_0004166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ34"/>
    <dbReference type="STRING" id="8496.A0A151PJ34"/>
    <dbReference type="eggNOG" id="KOG3530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13186">
        <property type="entry name" value="FERM_C_NBL4_NBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17107">
        <property type="entry name" value="FERM_F1_EPB41L4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000116">
        <property type="entry name" value="band 4.1-like protein 4A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030696">
        <property type="entry name" value="Band4.1-like4A_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF4">
        <property type="entry name" value="BAND 4.1-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="11"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO48805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="706" mass="81218" checksum="AC16E943C9D9C9A2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJB3</accession>
    <name>A0A151PJB3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Quinone oxidoreductase PIG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TP53I3</name>
        <name evidence="5" type="ORF">Y1Q_0020223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000178">
        <property type="protein sequence ID" value="KYO48875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006278758.1">
        <property type="nucleotide sequence ID" value="XM_006278696.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019336891.1">
        <property type="nucleotide sequence ID" value="XM_019481346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJB3"/>
    <dbReference type="STRING" id="8496.A0A151PJB3"/>
    <dbReference type="GeneID" id="102564248"/>
    <dbReference type="KEGG" id="amj:102564248"/>
    <dbReference type="CTD" id="9540"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000314">
        <property type="entry name" value="Quinone oxidoreductase PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO48875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="340" mass="36658" checksum="46DEAD82741AD51C" modified="2016-06-08" version="1">MQDKEKMLAAHFDSPGGPENLYVKEVMKPHPREGEVLMKVSASALNRADLLQRRGKYPPPKGASDILGLEAAGIVAGFGPGCKKQWKIGDPVMALLSGGGQAEYVTVPEGHLIPVPNDMSLVQAAAIPEAWLTAFQLLHFVGKVQSGETVLIHAGASGVGTAAVQLARLEGAIPIVTAGTQEKLQMAAKLGAAAGFNYKEEDFSEKVLEFTHGSGVGVILDCIGGSYWEKNISCLSTDGRWVVYGLLTGGEIHGDLLTRLLFKRGSLLTTLLRSREKEYKEQLVKAFTERVLPHFSRNISPSLQPVIDSIYPLHKIGEAHKLMEENKNVGKVIIEMPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZ99</accession>
    <name>A0A151LZ99_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor SOX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SOX12</name>
        <name evidence="10" type="ORF">Y1Q_0009421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006953">
        <property type="protein sequence ID" value="KYO17605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZ99"/>
    <dbReference type="STRING" id="8496.A0A151LZ99"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048593">
        <property type="term" value="P:camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22038">
        <property type="entry name" value="HMG-box_SoxC_SOX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000007">
        <property type="entry name" value="Transcription factor SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017386">
        <property type="entry name" value="SOX-12/11/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF221">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038098">
        <property type="entry name" value="SOX-12/11/4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="9">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO17605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="290" mass="32029" checksum="66760D6F6D0F8756" modified="2016-06-08" version="1">MEAKREGCPADLKEAGAKGEPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVKEAERLRLKHMADYPDYKYRPRKKGKVGAGKARPRLPVKIKPSVLGRVASGRRQPPKPEPGGKAEEPPGGQVPEDAGPKTPGKCWPAGETDDAPEEPHAGPDPEASAQPFLEQLRPAGSESPSPMSAGSPPSSFASSDEELEEELLGVLPGRAPPSAALDWAVVDKDLDLFPRGIPSHFEFPDYCTPEVREMIAGDWLMSSISDLVFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M052</accession>
    <name>A0A151M052_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TLK2</name>
        <name evidence="17" type="ORF">Y1Q_0011521</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M052"/>
    <dbReference type="STRING" id="8496.A0A151M052"/>
    <dbReference type="eggNOG" id="KOG1151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14040">
        <property type="entry name" value="STKc_TLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000037">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOUSLED-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="437"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="53"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO17862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="747" mass="85029" checksum="284D6A154EC7771B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1U5</accession>
    <name>A0A151M1U5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein TALPID3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0014759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1U5"/>
    <dbReference type="STRING" id="8496.A0A151M1U5"/>
    <dbReference type="eggNOG" id="ENOG502QUXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029246">
        <property type="entry name" value="TALPID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721">
        <property type="entry name" value="KIAA0586 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15721:SF2">
        <property type="entry name" value="PROTEIN TALPID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15324">
        <property type="entry name" value="TALPID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO18483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="864" mass="96646" checksum="8C73A87A78002E5D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3S6</accession>
    <name>A0A151M3S6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006711">
        <property type="protein sequence ID" value="KYO19146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3S6"/>
    <dbReference type="KEGG" id="amj:106738204"/>
    <dbReference type="eggNOG" id="ENOG502SHG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9420366at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="445" mass="51630" checksum="2297FC31240B821D" modified="2016-06-08" version="1">MCLKPQKEPLKLSIESLRKVQAQLESKRLMTPMLRRCFELALKQFPQEPQCVQDNAQMVIASQMMELKFVSGEGECKIKVSSAEGCPQYKVGEPTKSMYLDRLLHQPQLLTTENLKNIKKTLETWGSLSEEMELCFEEVLKEFPQETLCVRSNAYLVIHCDGMELRFVSGERKCEIAVCSSEPRYRVKELTAEVFLERLLSRPQRLSMENLQRIRKGLASWTEISTELRACFNLFLEKFPNEPACIQEIPTMNMKWDGTRLQFLEGDLTVTVTWLNDKATYNVQVKTWAIYQEMLKLSEQPLSKENLLMVRQKVRNLQGVPDKVEDVFNMAIEKFFAEQEVLQNNAKLVMKCDVGEIVFVSGKGENIVDVYLSDGKVYYKNLQETTEVKFLKTLMDIISSLWEALINNMVKRFSEFLELLPTIGKYMVKHFPEFLKLLPLIGKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3Z0</accession>
    <name>A0A151M3Z0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PCAF-associated factor 65-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TAF6L</name>
        <name evidence="14" type="ORF">Y1Q_0020192</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006649">
        <property type="protein sequence ID" value="KYO19235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M3Z0"/>
    <dbReference type="GeneID" id="102563678"/>
    <dbReference type="KEGG" id="amj:102563678"/>
    <dbReference type="CTD" id="10629"/>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6621890at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22932">
        <property type="entry name" value="HFD_TAF6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000040">
        <property type="entry name" value="TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000002">
        <property type="entry name" value="TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF22">
        <property type="entry name" value="TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="13">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="377"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="455"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO19235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="629" mass="68981" checksum="E97AF09EC4F5E0FE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6Z4</accession>
    <name>A0A151M6Z4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="35">Non-selective voltage-gated ion channel VDAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="36">Voltage-dependent anion-selective channel protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="primary">VDAC1</name>
        <name evidence="40" type="ORF">Y1Q_0010818</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="40 41" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="40">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="34">Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>ATP(in) = ATP(out)</text>
            <dbReference type="Rhea" id="RHEA:75687"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>Fe(III)-[cytochrome c](out) = Fe(III)-[cytochrome c](in)</text>
            <dbReference type="Rhea" id="RHEA:79311"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>acetylcholine(in) = acetylcholine(out)</text>
            <dbReference type="Rhea" id="RHEA:74663"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>dopamine(out) = dopamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73863"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="37">Homodimer and homotrimer; in response to cyclic AMP or calcium; oligomerization is required for scramblase activity. Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF. Interacts with SPG7, NIPSNAP2 and SLC25A30. Interacts with hexokinases including HK1. The HK1-VDAC1 complex interacts with ATF2. Interacts with BCL2L1. Interacts with BAK1. Interacts with RTL10/BOP (via BH3 domain). Interacts with amyloid-beta and APP; induces VDAC1 dephosphorylation. Interacts with TMEM41B. Interacts with BCAP31. Interacts with HSPA9; this interaction couples ITPR1 to VDAC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="40">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6Z4"/>
    <dbReference type="STRING" id="8496.A0A151M6Z4"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000001">
        <property type="entry name" value="Voltage-dependent anion-selective channel protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF13">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17818">
        <property type="entry name" value="KCT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="21 39" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0626">Porin</keyword>
    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 39" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="39" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="39">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="38">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00036683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00036778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00044892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00044897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00044941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00044987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00045025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00046417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="KYO20277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="581" mass="64167" checksum="CABCD763FD0E94C7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7T2</accession>
    <name>A0A151M7T2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fetuin-B isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FETUB-1</name>
        <name evidence="10" type="ORF">Y1Q_0014848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006382">
        <property type="protein sequence ID" value="KYO20500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7T2"/>
    <dbReference type="STRING" id="8496.A0A151M7T2"/>
    <dbReference type="eggNOG" id="ENOG502S28K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000009">
        <property type="entry name" value="Alpha-2-HS-glycoprotein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000005">
        <property type="entry name" value="Histidine-rich glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025760">
        <property type="entry name" value="Cystatin_Fetuin_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025764">
        <property type="entry name" value="Cystatin_Fetuin_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050735">
        <property type="entry name" value="Kininogen_Fetuin_HRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001363">
        <property type="entry name" value="Prot_inh_fetuin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814">
        <property type="entry name" value="FETUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814:SF10">
        <property type="entry name" value="FETUIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51529">
        <property type="entry name" value="CYSTATIN_FETUIN_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51530">
        <property type="entry name" value="CYSTATIN_FETUIN_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01254">
        <property type="entry name" value="FETUIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01255">
        <property type="entry name" value="FETUIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cystatin fetuin-A-type" evidence="8">
        <location>
            <begin position="240"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin fetuin-A-type" evidence="8">
        <location>
            <begin position="365"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin fetuin-B-type" evidence="9">
        <location>
            <begin position="569"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin fetuin-B-type" evidence="9">
        <location>
            <begin position="693"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="816"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO20500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="964" mass="106177" checksum="F938A38AE470FD63" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8T4</accession>
    <name>A0A151M8T4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADPH oxidase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NOX5</name>
        <name evidence="9" type="ORF">Y1Q_0001261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>NADPH + 2 O2 = 2 superoxide + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63180"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO20927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8T4"/>
    <dbReference type="STRING" id="8496.A0A151M8T4"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000056">
        <property type="entry name" value="NADPH oxidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000012">
        <property type="entry name" value="NADPH oxidase, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF58">
        <property type="entry name" value="NADPH OXIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="153"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO20927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="531" mass="60581" checksum="A2B4B7B305A44562" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAH9</accession>
    <name>A0A151MAH9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 33 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC33-1</name>
        <name evidence="4" type="ORF">Y1Q_0001717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAH9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039889">
        <property type="entry name" value="CCD33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623">
        <property type="entry name" value="SPERIOLIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="335"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="872"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO21537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1148" mass="129466" checksum="303E1464FDCEC5F0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBF4</accession>
    <name>A0A151MBF4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">NAT10</name>
        <name evidence="17" type="ORF">Y1Q_0000537</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with THUMPD1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with THUMPD1. Interacts with SUN1 (via N-terminus). Interacts with TERT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MBF4"/>
    <dbReference type="eggNOG" id="KOG2036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000006">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000019">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022070">
        <property type="entry name" value="Caprin-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041637">
        <property type="entry name" value="Caprin-1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12287">
        <property type="entry name" value="Caprin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18293">
        <property type="entry name" value="Caprin-1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="1287"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="365"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="469"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1718"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1739"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="1358"/>
            <end position="1360"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="1365"/>
            <end position="1371"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1454"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO21857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1748" mass="197331" checksum="41555295D9329DFA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC58</accession>
    <name>A0A151MC58_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha</fullName>
            <ecNumber evidence="10">2.7.1.137</ecNumber>
            <ecNumber evidence="8">2.7.1.153</ecNumber>
            <ecNumber evidence="9">2.7.1.154</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Phosphoinositide 3-kinase-C2-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="38" type="ORF">Y1Q_0000700</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="38 39" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18373"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:18374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.153"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:21293"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="38">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="10"/>
    <dbReference type="EC" id="2.7.1.153" evidence="8"/>
    <dbReference type="EC" id="2.7.1.154" evidence="9"/>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MC58"/>
    <dbReference type="eggNOG" id="KOG0905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046934">
        <property type="term" value="F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <source>
            <dbReference type="EMBL" id="KYO22091.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
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    </evidence>
    <sequence length="1691" mass="190434" checksum="AE40F5BFE791E671" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDI5</accession>
    <name>A0A151MDI5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell surface A33 antigen isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPA33-1</name>
        <name evidence="12" type="ORF">Y1Q_0003119</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDI5"/>
    <dbReference type="STRING" id="8496.A0A151MDI5"/>
    <dbReference type="eggNOG" id="ENOG502QR0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000095">
        <property type="entry name" value="immunoglobulin superfamily member 11 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042474">
        <property type="entry name" value="A33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44969">
        <property type="entry name" value="CELL SURFACE A33 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44969:SF1">
        <property type="entry name" value="CELL SURFACE A33 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585006" evidence="10">
        <location>
            <begin position="19"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO22596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="290" mass="32148" checksum="6563207816A00120" modified="2016-06-08" version="1">MKRPELFIFSLALATAHGSTVTAPDKEVKVARGHNVTLRCEFQTTGTAESGDFVYWKKTQIMHEVVIRYFDGFIRYGASYKDRIYFSGNPDKGDFSITLTEVTMEDNGTYACGVHLRMETVEPAYVALFVRVAPSKPDCAIQGTAEYGHTVNLTCNSREGSPKPVYTWQSFNVQNQPRPLQATQGQLITLKNVSAETSGFYICTSTNSVGHQFCNMTVSIMPPSMNFALYAGIIGGVVAAIIVIGILAYCCCCRSKKDKDYEMTEREDRIEDATMNQEADEGKDLEGEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDN9</accession>
    <name>A0A151MDN9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDN9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="8258" checksum="17225DECA6780713" modified="2016-06-08" version="1">MGNVPPGMLGRDTQYCAQVRGGRQSHPGVACLRVWTSRSYAHHAESTGKQAFRRQGAREVHSRPKIHFLSWEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEI7</accession>
    <name>A0A151MEI7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interferon-related developmental regulator 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IFRD2</name>
        <name evidence="5" type="ORF">Y1Q_0005442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO22927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEI7"/>
    <dbReference type="STRING" id="8496.A0A151MEI7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006921">
        <property type="entry name" value="Interferon-rel_develop_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF8">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04836">
        <property type="entry name" value="IFRD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon-related developmental regulator C-terminal" evidence="3">
        <location>
            <begin position="405"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO22927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="461" mass="51478" checksum="C9788FC3530CBAF6" modified="2016-06-08" version="1">MAQLGRSVWHPHSNLRGMVVHRQEIQSLHGEGGSPSWTTRARSSAKADSQASDDEAASEVLSHYSSASEGTSVAEEGTGSDTVDEQAQQEEVEDKLKECIDNVLDKSAKTRQVALENLRLAFSSKMLFDFLLERRLTLTDSLEKCLKKGKGEEQSLAATVLTLLCLQMGSGPEGEEVFRSLKPLLINILTDTSASPISRQSCAVALGMCCYIAAADLEDLISCLTCLEGIFSTSCPEEGNSMPAQHSPLLQTLHCNALQSWSLLLTICPSSYIKKILDNHLLKLPLMLSSDNVNLRITAGETIALLFELARDMEEDNFYEDTDLLCTKLKALATDSNKYRAKTDRRRQRSIFRDVLHFIESGEFHEETIRFGLECMYVDSWVRRRTYDAFKEVLGSGVRHHLQNNELLREIFDLGPPLVLDAAAIKASKISRFEKHLYNSAAFKARTKARSRVRDKRADIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEX7</accession>
    <name>A0A151MEX7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEX7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="12781" checksum="4DD9D344F8B83B0A" modified="2016-06-08" version="1">MSLQCREDKRSRDGRYSYSQELLKYLRQTVRALPLPFGWVACARSSLMGFIPPNCIEDRAKADRRREREKYNRQTMGEKTMEKGRAALELLAPISWERGDPEHLITVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFL0</accession>
    <name>A0A151MFL0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Orexigenic neuropeptide QRFP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">QRFP</name>
        <name evidence="7" type="ORF">Y1Q_0005705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RFamide neuropeptide family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFL0"/>
    <dbReference type="STRING" id="8496.A0A151MFL0"/>
    <dbReference type="eggNOG" id="ENOG502S84J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031854">
        <property type="term" value="F:orexigenic neuropeptide QRFP receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024565">
        <property type="entry name" value="P518"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36476">
        <property type="entry name" value="OREXIGENIC NEUROPEPTIDE QRFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36476:SF1">
        <property type="entry name" value="OREXIGENIC NEUROPEPTIDE QRFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11109">
        <property type="entry name" value="RFamide_26RFa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="5 7" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO23305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="161" mass="17753" checksum="A06C3751D549B032" modified="2016-06-08" version="1">MEGFPRGLGPGRASWTGQTSCQGRGHVGEPLKRSRMKAPYSLSCLLMLSLGTCFPPDDRTGPGDPGPALPLEPSWWDVVAWKRSTEDLSSLFSMAKELQGFDQEQASFGQQQERPGEEGEGIRFQPRDDGEKRSGVLGSLAKELNGYNRKKGGFSFRFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGP9</accession>
    <name>A0A151MGP9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGP9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO23688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="8752" checksum="38EAE0CC78C0DAC6" modified="2016-06-08" version="1">MPPFPGRGVADRTPPTPLREAEVQRALTPSSRGGTRRIGAWLFSMSPEVDFGWCFLLFRVPVKNRIVPWSKADAKSGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGQ0</accession>
    <name>A0A151MGQ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGQ0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="94" mass="11132" checksum="7EBA7E833563E755" modified="2016-06-08" version="1">MAESDYFLPSYHSLRQDRGSCWQDGQMDGKLPHGLKHAVHIYLDPEGLAWHILEPKEQITFLSVSMLYNKAQEQMDSKEKYRKKMRRDDGKMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MH49</accession>
    <name>A0A151MH49_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0015827</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MH49"/>
    <dbReference type="STRING" id="8496.A0A151MH49"/>
    <dbReference type="KEGG" id="amj:102558879"/>
    <dbReference type="eggNOG" id="KOG0690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01241">
        <property type="entry name" value="PH_PKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05593">
        <property type="entry name" value="STKc_PKB_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000033">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000027">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000838">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034675">
        <property type="entry name" value="Akt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039026">
        <property type="entry name" value="PH_PKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="148"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="406"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO23838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="479" mass="55759" checksum="F09D113C46E2A2FB" modified="2016-06-08" version="1">MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFAGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHD7</accession>
    <name>A0A151MHD7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">SAMHD1</name>
        <name evidence="27" type="ORF">Y1Q_0013288</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:46149"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dATP + H2O = 2'-deoxyadenosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67649"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dCTP + H2O = 2'-deoxycytidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:80084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:15194"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dTTP + H2O = thymidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80079"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:80080"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SAMHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006169">
        <property type="protein sequence ID" value="KYO23800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059589264.1">
        <property type="nucleotide sequence ID" value="XM_059733281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHD7"/>
    <dbReference type="STRING" id="8496.A0A151MHD7"/>
    <dbReference type="GeneID" id="102571689"/>
    <dbReference type="CTD" id="25939"/>
    <dbReference type="eggNOG" id="KOG2681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045088">
        <property type="term" value="P:regulation of innate immune response"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09508">
        <property type="entry name" value="SAM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000015">
        <property type="entry name" value="Deoxynucleoside triphosphate triphosphohydrolase SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000067">
        <property type="entry name" value="SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2760:FF:000002">
        <property type="entry name" value="SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="15" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAM" evidence="25">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="26">
        <location>
            <begin position="167"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO23800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="629" mass="72894" checksum="9DF1DAA030A29CD3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MI75</accession>
    <name>A0A151MI75_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Hemicentin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Fibulin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Y1Q_0004265</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes. Plays a role in basement membrane organization. May promote cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00255">
        <property type="entry name" value="nidG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000210">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000238">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000352">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000371">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000383">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000385">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000067">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.155.10:FF:000002">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000130">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000186">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000279">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000285">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000503">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000594">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000675">
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    <dbReference type="FunFam" id="2.60.40.10:FF:000749">
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO24216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="5434" mass="590461" checksum="1AC2F3F6DD9DF9F0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJF9</accession>
    <name>A0A151MJF9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Blood vessel epicardial substance isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BVES</name>
        <name evidence="17" type="ORF">Y1Q_0017767</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the popeye family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006032">
        <property type="protein sequence ID" value="KYO24664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJF9"/>
    <dbReference type="STRING" id="8496.A0A151MJF9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000166">
        <property type="entry name" value="blood vessel epicardial substance isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006916">
        <property type="entry name" value="POPDC1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055272">
        <property type="entry name" value="POPDC1-3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101:SF17">
        <property type="entry name" value="BLOOD VESSEL EPICARDIAL SUBSTANCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101">
        <property type="entry name" value="POPEYE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04831">
        <property type="entry name" value="POPDC1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="POPDC1-3" evidence="16">
        <location>
            <begin position="135"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO24664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="448" mass="51533" checksum="505AF95F16DADF77" modified="2016-06-08" version="1">MLQYLVFKDAYLEEKRKKQRTVYQMTTDSWINMYPVKLFPYSHTIVCWYHLPRKKEFDDGTFIPGGRGAGPHGASSRLRQHELGKFGGGGSGAFKMNSTEIISLTVTPLGVIPDFKNATLVPFNETACENWKEIHHLVFHVANTCFAAGLVIPTTLNFHMIFLRSLLTIGCVMFIIWATFFRCAVDIMIWNTVFLVINFLHFIYLVYKRRPIKIEKELSSLYKRMFEPLHVPPELFKRLTGQFCNIQTLKTGQAYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPCAFIDSPEFRSTQMNRGEKFQVTIVADDNCKFLCWSRERLTYFLEAEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKTSKQMDRQPSLCSQLSVMQMRNSMASSSDSEDGLQQFLLGTSSASSLRRASPYMRTSAKMKPIEESVEDDVFEASSSKSEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKY0</accession>
    <name>A0A151MKY0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005917">
        <property type="protein sequence ID" value="KYO25182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKY0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23627" checksum="9F7E26168CD82514" modified="2016-06-08" version="1">MPQLMVPIPASAPRTPDTTRDPHFMQKSLVQFLDNFLWTSQKDYTEANVKLEKYKLDYTTVEFLEFHQGQKGHLYQDKEANKHYVKHYHSEAPMFRMGDKDVLWVQDPLEVMVEFCTLGFSQCIRALDRTHIPISCPPHGHRPYYSWQGFHFIMFQAIIDHCSAFTNMSASTHDAHIFCNPALPTLVESGQLCQECQTSNWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MM54</accession>
    <name>A0A151MM54_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Tumor protein 63 (p63)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TP63</name>
        <name evidence="19" type="ORF">Y1Q_0013765</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the p53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005724">
        <property type="protein sequence ID" value="KYO25602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MM54"/>
    <dbReference type="STRING" id="8496.A0A151MM54"/>
    <dbReference type="eggNOG" id="ENOG502QQ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08367">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09572">
        <property type="entry name" value="SAM_tumor-p63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000002">
        <property type="entry name" value="Cellular tumor antigen p53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.170.10:FF:000001">
        <property type="entry name" value="Cellular tumor antigen p53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000020">
        <property type="entry name" value="Tumor protein 63 (p63)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057064">
        <property type="entry name" value="P53_central_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010991">
        <property type="entry name" value="p53_tetrameristn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037611">
        <property type="entry name" value="Tumor-p63_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447:SF8">
        <property type="entry name" value="TUMOR PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07710">
        <property type="entry name" value="P53_tetramer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00386">
        <property type="entry name" value="P53SUPPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47719">
        <property type="entry name" value="p53 tetramerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00348">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0010">Activator</keyword>
    <keyword evidence="4 16" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 13 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAM" evidence="18">
        <location>
            <begin position="591"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="401"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="486"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="14">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="15">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602117-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO25602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="730" mass="82071" checksum="EE534E6177C53EDE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN65</accession>
    <name>A0A151MN65_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0003767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN65"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8537" checksum="0259661BF006DE22" modified="2016-06-08" version="1">MSRSDAIRTIPKQCTYTTRSCLFVQVKHLFGIQLYKCGFFLFLMFREQGHKIFKWSFLSAQSFTQENLYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNE8</accession>
    <name>A0A151MNE8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbonic anhydrase</fullName>
            <ecNumber evidence="6">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CA8</name>
        <name evidence="8" type="ORF">Y1Q_0003812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Does not have a carbonic anhydrase catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNE8"/>
    <dbReference type="STRING" id="8496.A0A151MNE8"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000006">
        <property type="entry name" value="Carbonic anhydrase-related protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF104">
        <property type="entry name" value="CARBONIC ANHYDRASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO26052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="303" mass="34896" checksum="93FDEF5621C8730E" modified="2016-06-08" version="1">MADKSFIEESELCPRKDEALEWGYEEGVEWGLIFPDANGEYQSPINLNSREANYDPSLLEVHLTPNYVVCRDCEVINDGHSIQIVLKSKSVLVGGPLPRGHEFELYDVRFHWGRENQRGSEHTVNFKAFPMELHLMHWNSTLYNSIEEAVGKKHGIAIIALFVQIGKEHAGLKAVTEVLQDIQYKGKSKTIPCFNPNSLLPDPLLRDYWVYEGSLTIPPCSEGVTWILFRYPLTLSQLQIEEFRRLRTHIKVAEEERQQNKSLYIEGEDNAPTVPLDEKWKLLRLLLQFNHKACIVCLHLIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNU8</accession>
    <name>A0A151MNU8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CAP2</name>
        <name evidence="9" type="ORF">Y1Q_0001997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005656">
        <property type="protein sequence ID" value="KYO26186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNU8"/>
    <dbReference type="STRING" id="8496.A0A151MNU8"/>
    <dbReference type="eggNOG" id="KOG2675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028417">
        <property type="entry name" value="CAP_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF2">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01089">
        <property type="entry name" value="CAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585300" description="Adenylyl cyclase-associated protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="8">
        <location>
            <begin position="373"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO26186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="533" mass="59195" checksum="E5F19FEF9751C3F4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRI7</accession>
    <name>A0A151MRI7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural killer cell receptor 2B4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0022346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005314">
        <property type="protein sequence ID" value="KYO27147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRI7"/>
    <dbReference type="eggNOG" id="ENOG502S7N7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024303">
        <property type="entry name" value="NK_rcpt_2B4_Ig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF56">
        <property type="entry name" value="NATURAL KILLER CELL RECEPTOR 2B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11465">
        <property type="entry name" value="Receptor_2B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO27147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="262" mass="29267" checksum="96099B89E8EAECD4" modified="2016-06-08" version="1">MDLMLGDGSGITNNFQLFVIDHVQQPRIKASTSQECGRCYLTLSCLVPKAAWVTYSWSRGVSSHPTPEDHWLQEHQANVQLEITKSDSNTFYHCNVSNAISWAMATIDVKPLCNYTGCQEVKVEAAVGEMVQLQPKTWPLYWLAIHWEVELGSQTYWILRHEQNSTSANLLLPFADRVSFHPGNLSLQINSVTEKESGLYTMDLKLGDGSNITSYFRLFVLVPASSLSYCQAKGHILLLVLGALITGTVAVNIMAGKQEKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRZ4</accession>
    <name>A0A151MRZ4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0011160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005250">
        <property type="protein sequence ID" value="KYO27200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRZ4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585404" description="Death domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="58"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO27200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="286" mass="32010" checksum="6957F40B3EF7C292" modified="2016-06-08" version="1">MFRAAGIALLLLVTGVACDDTAADDIGPHTMGRIAELLSPEECHEFYVDITSPEEDVDKELARLSEENNPIHARPRRAIASTEQCRDILTQWLRTDGDALYWDRLARALRRIGRPDVSYELGKNLNQDKNLELKRNVDEYHERVAHLTSSLLLEDDEKYGERQRRGQARRARGAGLALEAWDDLELVIERRPQPPYNRSLFSWVSPVATGFVGGLLASVLLVAAALYSCLWAPSPDALGPPHHSRDSPLPPLAHARWGVDSHSYPWLVNHDLEEEASDDASLDGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSR3</accession>
    <name>A0A151MSR3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipase D3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0018831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005153">
        <property type="protein sequence ID" value="KYO27546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSR3"/>
    <dbReference type="STRING" id="8496.A0A151MSR3"/>
    <dbReference type="KEGG" id="amj:102565685"/>
    <dbReference type="eggNOG" id="KOG3603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1923775at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF26">
        <property type="entry name" value="PHOSPHOLIPASE D FAMILY, MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO27546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="679" mass="73765" checksum="A7B66F144FC81E58" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU73</accession>
    <name>A0A151MU73_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RPS6KB1</name>
        <name evidence="19" type="ORF">Y1Q_0005080</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03005047">
        <property type="protein sequence ID" value="KYO28081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MU73"/>
    <dbReference type="STRING" id="8496.A0A151MU73"/>
    <dbReference type="KEGG" id="amj:102571014"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MU73"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05584">
        <property type="entry name" value="STKc_p70S6K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000587">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000092">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016238">
        <property type="entry name" value="Ribosomal_S6_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000605">
        <property type="entry name" value="Ribsml_S6_kin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="63"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="325"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="402"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="69"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO28081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="475" mass="52433" checksum="E0B607EE3FE3310D" modified="2016-06-08" version="1">MAGVFDIDLETEEGSEGEEPELGAEMDLELRGNGLEPVGHYEEIEISESSVNNGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNAGRIFAMKVLKKAKIACNAKDTAHTKAERNILEAIKHPFIVDLIYAFQTGGKLYLILECLSGGELFMQLEREGIFLEDTACFYLSEITLALGHLHSNGIIYRDLKPENIMLNSQGHIKLTDFGLCKESIHDGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTIDKILKGKLVLPPYLTPDARDLLKKFLKRNPGQRIGGGAGDAADVQKQPFFRHVNWDDLLARKLDPPFKPCLQSDDDVSQFDTRFTRQTPVDSPDDASISESANQAFLGFTYVAPSVLESIKEGFSFQPKVRSPRRLNSSPRTPVSPVKFSPFEAFKPSPTTEPMELGSTLPPPPPEGTAPLPIKTPAGAKKQKGGRGRVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUC6</accession>
    <name>A0A151MUC6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nck-associated protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NCKAP5L</name>
        <name evidence="4" type="ORF">Y1Q_0012958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005039">
        <property type="protein sequence ID" value="KYO28131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUC6"/>
    <dbReference type="STRING" id="8496.A0A151MUC6"/>
    <dbReference type="eggNOG" id="ENOG502RB0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032769">
        <property type="entry name" value="NCKAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026163">
        <property type="entry name" value="Nckap5l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21740">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21740:SF3">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15246">
        <property type="entry name" value="NCKAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nck-associated protein 5 C-terminal" evidence="3">
        <location>
            <begin position="731"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="813"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO28131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1191" mass="125256" checksum="697A30C6BAE95608" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUI4</accession>
    <name>A0A151MUI4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrous sheath-interacting protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0010549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005021">
        <property type="protein sequence ID" value="KYO28145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUI4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038891">
        <property type="entry name" value="FSIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031554">
        <property type="entry name" value="FSIP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21856">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21856:SF7">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15783">
        <property type="entry name" value="FSIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrous sheath-interacting protein 2 C-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO28145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="341" mass="38322" checksum="681D023164C91AC8" modified="2016-06-08" version="1">MKKNKTKEMTDAVTNIMTWFVDEVTDILYPAIMEYEERKITKRDMRDEEASAKKAEVNSLAENLNQAMEKGLSRHQISLVLATEEEPPLRPEQEGALIPGGRKYYLIMPQQSGSEQDLCNDVTGFDAQLPQDVVTVIIEEISDRPLLRVVINRLSQSTTDPDRLANEALSHESISAEPKSWLNEEAVPGTSADKTPTGTEELAMLRALLPKVDLLAQLAAHYTEDEEGEERVEDDLESQQQWEEEEELQQIEETTPVKSCPYLWSPLGSFMDTEPSSVAVEGLSASLEAQTSLEWMSADTWLAWDREDSLDTAVVRILSSLSSRRHLKMLDLLYQASCGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVL2</accession>
    <name>A0A151MVL2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Basic proline-rich protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004884">
        <property type="protein sequence ID" value="KYO28586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVL2"/>
    <dbReference type="STRING" id="8496.A0A151MVL2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="131" mass="13301" checksum="BAE103EACAFCBABF" modified="2016-06-08" version="1">MESSGTGPSLPGAQDSQDSNPETAAGLTRPATGAPQDPASPDQHPDRAAPVLPGVQELAGGPLPSDQQSETQECMVDSQPILFSENPFVVANRRGKAAGKACLGGPPLGYGRGGVLKTNLYSKASALQHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWH0</accession>
    <name>A0A151MWH0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWH0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="99" mass="10861" checksum="33AFDB28F677039D" modified="2016-06-08" version="1">MLRPRGGTRQLLYGAAAEIFKIMNFPLNLRQGKVGCCVIGKLFPSQLWSEVGSAVKDVCFCVEVSGFPGLNPREHHRLDLLSDNLTSGAPLPHVRPTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX78</accession>
    <name>A0A151MX78_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multicilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Multiciliate differentiation and DNA synthesis-associated cell cycle protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Protein Idas</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MCIDAS</name>
        <name evidence="14" type="ORF">Y1Q_0009908</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the geminin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX78"/>
    <dbReference type="STRING" id="8496.A0A151MX78"/>
    <dbReference type="KEGG" id="amj:102559096"/>
    <dbReference type="eggNOG" id="ENOG502R4B5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9445365at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22590">
        <property type="entry name" value="McIdas_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1180:FF:000001">
        <property type="entry name" value="Truncated geminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1180">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022786">
        <property type="entry name" value="Geminin/Multicilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372">
        <property type="entry name" value="GEMININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372:SF3">
        <property type="entry name" value="MULTICILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07412">
        <property type="entry name" value="Geminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111469">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO29114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="301" mass="32939" checksum="905582B010558F15" modified="2016-06-08" version="1">MPWLPLRKGQGFVRTRRVWGRGPGQAPCLQPELSFDFQEFRDAVSTFLPDPTDLMPPPLDAAGFSFPLSDGSAFSPCLQTAPGASIPQPSLPGAAPAEQYWKEVADHNQRALGDALVENSQLHVTLSQKQEEITSLKEKNVQLKELASQAKQLASVLNRLLVQQAQEAPDASHPKGSVKRSLEDLFATGQEGCEGVDEILQEISDKCHAALQTLDESKDMKRLRLQVEECQAIPLHGAFNGLETCCSQSSVELGDSELEEGLAFRTSIKEHGTIRTLAFPQGNAFTIRTATGGYKFRWVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXC9</accession>
    <name>A0A151MXC9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0009943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXC9"/>
    <dbReference type="STRING" id="8496.A0A151MXC9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048370">
        <property type="entry name" value="ZSWIM4-8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF3">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21055">
        <property type="entry name" value="ZSWIM4-8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585554" description="SWIM-type domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO29160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1012" mass="114609" checksum="DE0351231A8EA9E7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXI3</accession>
    <name>A0A151MXI3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0007731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004707">
        <property type="protein sequence ID" value="KYO29227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXI3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045180">
        <property type="term" value="C:basal cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052212">
        <property type="entry name" value="PH-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156:SF23">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12156">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="172"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO29227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="272" mass="31603" checksum="536E3252D858C165" modified="2016-06-08" version="1">MHHSILHHHPPHGLGSRAEDPDHAYDTLSLESSDSLETSVSTGNNSACSPDNMSSASGMEVGKIEEMEKMLKEAHAEKSRLMESREREMELRRQALEDERRRREQLERRLQDETAQRQKLVEKEVKMREKHFSQARPLTRYLPIRKEDFDLKLHIESSGHSVDTCCHVILSEKMCKGYLVKMGGKIKSWKKRWFVFDRMKRTVSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKGLFNLSLANQLADILPTRFRREAAPAAHGEHGSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYF3</accession>
    <name>A0A151MYF3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDRGK domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DDRGK1</name>
        <name evidence="11" type="ORF">Y1Q_0004934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDRGK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004653">
        <property type="protein sequence ID" value="KYO29532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014452578.1">
        <property type="nucleotide sequence ID" value="XM_014597092.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYF3"/>
    <dbReference type="STRING" id="8496.A0A151MYF3"/>
    <dbReference type="GeneID" id="102568583"/>
    <dbReference type="KEGG" id="amj:102568583"/>
    <dbReference type="CTD" id="65992"/>
    <dbReference type="eggNOG" id="KOG3054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MYF3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903895">
        <property type="term" value="P:negative regulation of IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000143">
        <property type="entry name" value="DDRGK domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585586" description="DDRGK domain-containing protein 1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO29532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="297" mass="33943" checksum="A63C192AD305D600" modified="2016-06-08" version="1">MEAVLLALLAVVLAALLLLAARLRGPAAPAEEEHQRDVAAAVARPRPHAEERGEGMPRRRRNMGTRMLAERRAQQVDNWADEEEDGDEAPEVQVSGKIGAKKQRKLEEKQARKAQREAEEAEREERKKLESKREEERRKEEEKLRLEEERQEEEKKKAKEEEEQREYEEYLKLKESFIVEEEGVEEAMTEEESHSLLMEFLTYIKSTKVVQLEDLASHLGLRTQDAINRIQDLMADGTLTGVIDDRGKFIYITPEEMAAVAQYITQRGRVSIAELAQASDSLINLQPDSKAVTQTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYX4</accession>
    <name>A0A151MYX4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C-reactive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0017648</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pentraxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004558">
        <property type="protein sequence ID" value="KYO29668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYX4"/>
    <dbReference type="eggNOG" id="ENOG502S201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001849">
        <property type="term" value="F:complement component C1q complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00152">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000070">
        <property type="entry name" value="Serum amyloid P-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051005">
        <property type="entry name" value="Pentraxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45869:SF7">
        <property type="entry name" value="C-REACTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45869">
        <property type="entry name" value="C-REACTIVE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0011">Acute phase</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pentraxin (PTX)" evidence="12">
        <location>
            <begin position="70"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO29668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="285" mass="32470" checksum="485629228CBDD366" modified="2016-06-08" version="1">MQWLQCSSWENTPSGKEQEWPGVHGLVVPRGSCLSNNCCFPKLQKNMEKLLLWLLVLTGLSGITAQEDLFGHVLIFPKASPTAYIPLGTKNKQSLQSFTVCLRYFSDLTRDYSLFSYASRTSDNEILLFRSFPDVYKIYIGGTAVTFRVPEKEKKWPEWVHICTSWESATGIVQLWVDGKPLPRKGLQKGYSVKAEAVILLGQDQDSYGAGFDENQSFVGEITDVHMWDHVLTPAEIRLIKNNEVLPLHPMDWRNMSYEIKGYVLLKPSLCPMYRAPQATQEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZ85</accession>
    <name>A0A151MZ85_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Leucine-rich repeat and transmembrane domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LRTM1</name>
        <name evidence="18" type="ORF">Y1Q_0023152</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014452024.1">
        <property type="nucleotide sequence ID" value="XM_014596538.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZ85"/>
    <dbReference type="STRING" id="8496.A0A151MZ85"/>
    <dbReference type="GeneID" id="106737848"/>
    <dbReference type="KEGG" id="amj:106737848"/>
    <dbReference type="CTD" id="57408"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000015">
        <property type="entry name" value="Leucine rich repeat containing 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773:SF10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585596" evidence="16">
        <location>
            <begin position="21"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="17">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="345" mass="38332" checksum="1CD35A95B0BEB121" modified="2016-06-08" version="1">MKGYLLLISNVIILIYEVHGCPEKCLCHPPSKTVDCKNRGLVDIPSHLPSETQILLLQNNHIWRINQSAFTGAPWLKILELSNNSITSLASGAFQGLRYLQVLNLTKNLIHYVENKTFSSLPQLKELDLSSNRILSLPETLGKNTGNITLLSVKHNKLQKMERVLLESLPNLKVVLFKDNPWQCNCNVFGLKLWLESFLYRGGISDGIICSTPENRKGKDLLKVPYEMYGVCPATAAHVTLASFHHHTSEHRNSLKHAHHNEHGDSSHSDCEPKPKSRPVNLRHAIATVVITGVVCGIVCLMMLAAAVYGCAYAAITAKYHKEHLAPAIEQGSPEEKEPFDSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZC9</accession>
    <name>A0A151MZC9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box/WD repeat-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FBXW12</name>
        <name evidence="6" type="ORF">Y1Q_0023184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZC9"/>
    <dbReference type="STRING" id="8496.A0A151MZC9"/>
    <dbReference type="eggNOG" id="ENOG502R86T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052121">
        <property type="entry name" value="F-box_SCF_Substrate_Recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550:SF2">
        <property type="entry name" value="EXPRESSED SEQUENCE C85627-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO29844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="450" mass="49919" checksum="68C0E6481003751D" modified="2016-06-08" version="1">MGLALPLDCLVHVFSFLEPPDLLRAALVDKAWNEAADTTSLWRNMCLNRWTFCNILNLTPGVQTWKKYYLHRSKLEQQMTSGRPSADYTCIPMRGHSGKIMGMAYLSDSDHVFGAGQLRSVVCTASTDGTVRAWNVQEGIQIWSSPVQEMPLLKVITLPKYKVAITTDAHGTIKAWQGETGQELASFSTSSSSCNLVTYSVNKKPFLLAATAGGAVYTLEVPNLNQVSCITAFQNSKIDLLLCSPDKLWLVAGSTESADVSIKVFSTDCLIQPTEDKSHICTSLPVRKHVTACWLPKEPARIAVMHKDNAFQMNITVLDLAVKKSKYKSEILAQQVTSFTLPEKSWNTYSVMEGYGTETILIGCGSELKLYSISGTQLQCFQDHKDTITSLWVDSFRVVTSSLDLSLRVYMWKKANQAYALQSLYQLLGGSHKWSRGFIDVACDNVCCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZD2</accession>
    <name>A0A151MZD2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase domain-containing 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CECR5L</name>
        <name evidence="4" type="ORF">Y1Q_0023202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZD2"/>
    <dbReference type="STRING" id="8496.A0A151MZD2"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000081">
        <property type="entry name" value="Haloacid dehalogenase like hydrolase domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF43">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00069384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO29870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="432" mass="48222" checksum="3B9217F5913034DF" modified="2016-06-08" version="1">MFKQPEDTAETLPPALTNLSKTAVAGAQPHVQPTFGFLFDIDGVLVRGKTPIPAAKVAFQKLVNSQGHFLVPVVFVTNAGNCLRQKKADQLSHILGVPISQDQVMLSHSPLRMFKRYHDKCVLVSGQGPLLDIANCLGFCRPITIDMLREMYPLLDMVDHDRRPKILHSPAVDLPKIEAVVLFGEPIRWETNLQLIIDVLLTSGYPGNPYHHAKYPHIPVLACNMDLMWVAEAQSPRFGHGTFMVCLENIYKKITGKELKYEALMGKPSELTYHYAEYLIRTQAAERQWKKPIQSLYAIGDNLMTDIYGANLYNRYLEEKNSRRGSKARVQAKVAAGTRSTTVSQDDEISNTWESELASATATSCRSILVCTGVYNPHAEVSPETGESVTETVFHGHRDFRFDPALIEPDHIVPDVAAAVDLIFQLENFAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N029</accession>
    <name>A0A151N029_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger and BTB domain-containing protein 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZBTB46</name>
        <name evidence="12" type="ORF">Y1Q_0021181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004329">
        <property type="protein sequence ID" value="KYO30102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N029"/>
    <dbReference type="STRING" id="8496.A0A151N029"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001046">
        <property type="entry name" value="Zinc finger and BTB domain containing 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000379">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF21">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN CONTAINING 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO30102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="298" mass="33230" checksum="C287271B39F08126" modified="2016-06-08" version="1">MPSFLPASGWPYNSRDTSGDVTVTEPSSSDNRVERSDLYTNVDEALIGGEASYLSQPLTPEKDDALQAATVANLRAALMSKNSLLSLKADMLSEDSSLLFEYLPKGTHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCNRVFMSAASVGIKHGSRRHGVCADCSGRGMAGHLDQNGGEGSPDELYPGEGQYMEDPDDIKVEGDEEMGDDDDIKWKDDVGISQDDVILDDDKDVDSPQEQENSGENDKDFTWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0W4</accession>
    <name>A0A151N0W4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004278">
        <property type="protein sequence ID" value="KYO30299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0W4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="12173" checksum="2D3FB4C43B502DE2" modified="2016-06-08" version="1">MLTSPCGQAEWMEGVLELELDLHALGISHWAEYSPYPSPPPRTAQKGQEWEEELLDLRETGDSATFAPDLLTVGCGDLHGNSNPQTLDSSLRQAAFNSSKISRTECGSHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1V6</accession>
    <name>A0A151N1V6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1V6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10001" checksum="855E7E8339E28A47" modified="2016-06-08" version="1">MLTEEDCNVAVSSSFEDAGKTPSALNLAPEAVSLGQPGAPGGCCDVYPFPPLGHWPGTPCEHSTYGQREDFGEACGESLARSTFFIKERATKSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N380</accession>
    <name>A0A151N380_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DCTN6</name>
        <name evidence="9" type="ORF">Y1Q_0016998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004108">
        <property type="protein sequence ID" value="KYO31286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N380"/>
    <dbReference type="STRING" id="8496.A0A151N380"/>
    <dbReference type="GeneID" id="102573224"/>
    <dbReference type="KEGG" id="amj:102573224"/>
    <dbReference type="CTD" id="10671"/>
    <dbReference type="eggNOG" id="KOG4042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N380"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO31286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="190" mass="20612" checksum="ECE16FC0CF1454D2" modified="2016-06-08" version="1">MSEKLQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINGFPENITPDTEGIEPKPMVIGTNNVFEVGCFSQAMKVGDNNVIESKAFVGRNVILTSGCIIGACCNVNTYEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKAASTPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3U6</accession>
    <name>A0A151N3U6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TAR DNA-binding protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TARDBP</name>
        <name evidence="17" type="ORF">Y1Q_0006063</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3U6"/>
    <dbReference type="STRING" id="8496.A0A151N3U6"/>
    <dbReference type="eggNOG" id="ENOG502QPQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12321">
        <property type="entry name" value="RRM1_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000098">
        <property type="entry name" value="TAR DNA-binding protein 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000107">
        <property type="entry name" value="TAR DNA-binding protein 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049124">
        <property type="entry name" value="TDP-43_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20910">
        <property type="entry name" value="TDP-43_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="171"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="258"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO31481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="481" mass="51873" checksum="7A9E2B8295C2A2CF" modified="2016-06-08" version="1">MSVRGIRQGYDCPPLAPDLPQVDAVLPAKTPPSQFTQRQEALSAPQRGPYTPHPPRRSSPAPYPPAKMSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPEAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDIKTGHSKGFGFVRFTDYETQVKVMSQRHMIDGRWCDCKLPNSKQSPDEPLRSRKVFVGRCTEDMTADELRQFFSQYGEVVDVFIPKPFRAFAFVTFADDQVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERGGRFGGNPGGFGNQGGFGNSRGGGGGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQPQGNMQREQNQGFSSGNNSYGGSNSGAAIGWGSASNAGSSSGFNGGFGSSMDSKSSGWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4Q5</accession>
    <name>A0A151N4Q5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4Q5"/>
    <dbReference type="KEGG" id="amj:102576316"/>
    <dbReference type="eggNOG" id="ENOG502S8RG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2109241at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039471">
        <property type="entry name" value="CXorf65-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33887:SF1">
        <property type="entry name" value="GENE 867-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33887">
        <property type="entry name" value="PB1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15874">
        <property type="entry name" value="Il2rg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO31605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="160" mass="18369" checksum="B3DC3AF3520DAD0F" modified="2016-06-08" version="1">MFFTVRYGADCQAIFNLHCRILNLTAHLKRKCQCRPEDCIDLLDEAGILMNLSEVENPASELASKYLRERQCYILIRVIRGDHSEPIYYESLLENLGKYHPELPERLHKLSVNPQLKDSGRKSSIQRKIRPLKEPLVASPARFRSTPQSKKGSAVPGTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4X7</accession>
    <name>A0A151N4X7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coiled-coil domain-containing protein 90B, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0003439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004037">
        <property type="protein sequence ID" value="KYO31876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4X7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF14">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 90B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO31876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12161" checksum="D755723D48A60979" modified="2016-06-08" version="1">MRGCVLGRRLLACAGAALPGTAARRGFAATAFMKSYDVRRVEITPLEQRKLTFDTHALVRDLEARGFGKEQAETIVSALITLSNVSLDTVYKDMVTQAQQSPVSSTAKVDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N516</accession>
    <name>A0A151N516_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Disks large-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0003442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004037">
        <property type="protein sequence ID" value="KYO31880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N516"/>
    <dbReference type="STRING" id="8496.A0A151N516"/>
    <dbReference type="eggNOG" id="KOG0708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06723">
        <property type="entry name" value="PDZ1_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06724">
        <property type="entry name" value="PDZ2_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06795">
        <property type="entry name" value="PDZ3_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000091">
        <property type="entry name" value="disks large homolog 1 isoform X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000002">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019583">
        <property type="entry name" value="DLG1-4_PDZ_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019590">
        <property type="entry name" value="DLG1_PEST_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF6">
        <property type="entry name" value="DISKS LARGE HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10608">
        <property type="entry name" value="MAGUK_N_PEST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10600">
        <property type="entry name" value="PDZ_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01277">
        <property type="entry name" value="MAGUK_N_PEST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="109"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="204"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="433"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="548"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO31880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="67321" checksum="19D159F7CB7BB607" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5R7</accession>
    <name>A0A151N5R7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5R7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="105" mass="11590" checksum="802B1B7E728BCDFD" modified="2016-06-08" version="1">MSSAQQGHFWAQTCTSIQDLATVSREAPGTLTPVKFAGHHRRHFPFVCIQPFNPPANLAHSTHWEPGTLKANASTLPSCSCQPLSSNYGLFQWSEKFQPTCFSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N690</accession>
    <name>A0A151N690_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane-spanning 4-domains subfamily A member 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MS4A4A</name>
        <name evidence="7" type="ORF">Y1Q_0000387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003945">
        <property type="protein sequence ID" value="KYO32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N690"/>
    <dbReference type="STRING" id="8496.A0A151N690"/>
    <dbReference type="GeneID" id="102571141"/>
    <dbReference type="KEGG" id="amj:102571141"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF128">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="213" mass="22675" checksum="6CC68D44D9379287" modified="2016-06-08" version="1">MEQGAPGTVLLTQIVPPAQVPGTRPKPLEKFQQGEPLALGITQILVGIQQTAFGIIMIALVDYHYPALQVGTTIWTSVLCVISGSLSVAASRKPKIPLVKAVLALNSVSAVLLGVGLVVFFLSFTFLHGVHHCTWDPEQMECVPAPLEVQGILEGVIILLFILTLLQFCLALTGAAFGCKAICRDSYVDMAVVIYQHTEPSTNPTSAQTPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6E1</accession>
    <name>A0A151N6E1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003932">
        <property type="protein sequence ID" value="KYO32358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6E1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="8762" checksum="CB859F8AC640BA32" modified="2016-06-08" version="1">MRGHQRDSAFLGQAVRQAHACHRAGVTAGLGEEENPSTVQSIFHLMPAPCKSKLQSRSYKRALRMNFSLLFMLEGYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NA88</accession>
    <name>A0A151NA88_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Unconventional myosin-Ib</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Myosin I alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Y1Q_0008826</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NA88"/>
    <dbReference type="STRING" id="8496.A0A151NA88"/>
    <dbReference type="eggNOG" id="KOG0164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000007">
        <property type="entry name" value="Myosin-ib isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000004">
        <property type="entry name" value="unconventional myosin-Ib isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF277">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585871" description="Unconventional myosin-Ib" evidence="16">
        <location>
            <begin position="30"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="17">
        <location>
            <begin position="60"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="18">
        <location>
            <begin position="997"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1181" mass="136759" checksum="21EDEB3AEDD351A1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAD3</accession>
    <name>A0A151NAD3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Multidrug and toxin extrusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0015308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003672">
        <property type="protein sequence ID" value="KYO33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAD3"/>
    <dbReference type="STRING" id="8496.A0A151NAD3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048279">
        <property type="entry name" value="MdtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585879" description="Multidrug and toxin extrusion protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="521" mass="56124" checksum="644A2BE6B96709E8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAJ5</accession>
    <name>A0A151NAJ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nuclear receptor subfamily 1, group D, member 4a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NR1D4A</name>
        <name evidence="14" type="ORF">Y1Q_0017114</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003663">
        <property type="protein sequence ID" value="KYO33806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAJ5"/>
    <dbReference type="STRING" id="8496.A0A151NAJ5"/>
    <dbReference type="eggNOG" id="KOG4846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NAJ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07166">
        <property type="entry name" value="NR_DBD_REV_ERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000013">
        <property type="entry name" value="Nuclear receptor subfamily 1 group D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000039">
        <property type="entry name" value="Nuclear receptor subfamily 1, group D, member 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF501">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 4A ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="122"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO33806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="431" mass="47170" checksum="0886C384E661280C" modified="2016-06-08" version="1">MVLLCKVCGDIASGFHYGVHACEGCKGFFRRSIQQNIHYKMCVKNESCLIVRMNRNRCQHCRFKKCLAVGMSRDAVRFGRIPKREKQRLLDEMQSYMSSLGEAPLDAGLAPEGEAPPSPVAQEEEAIGAISRAYHDIFGSGQDRAGGPGPPPGYADLSPGYGYGQHDPASLRLPGYDPTSYPDNTSQRYGHDLYGAQQPGYLPSPGSYPAFEYGYAEGSPPRTCPWRGAASRGIACPLNASPCCSPGTSRQQAWEEFSRCFTPAVKEVVEFAKSIPGFQGLCQQDQVMLLKAGTFQVLMVRFAALFDPKEKAVTFLSGETHALGGLRAMGMGALLDAMFDFSEKLGTLGLDAQEMALFMAVVLVSADRSGISDVEAVEILQETLIRALRTLVTKKHPDDSTLFPKLLLRLPDLRTLNNQHSEKLLAFRIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBP9</accession>
    <name>A0A151NBP9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Erlin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ERLIN2</name>
        <name evidence="15" type="ORF">Y1Q_0002494</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003565">
        <property type="protein sequence ID" value="KYO34201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBP9"/>
    <dbReference type="STRING" id="8496.A0A151NBP9"/>
    <dbReference type="eggNOG" id="KOG2962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045541">
        <property type="term" value="P:negative regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03406">
        <property type="entry name" value="SPFH_like_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000009">
        <property type="entry name" value="Erlin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033294">
        <property type="entry name" value="Erlin1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351">
        <property type="entry name" value="ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351:SF4">
        <property type="entry name" value="ERLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="14">
        <location>
            <begin position="41"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="364" mass="40645" checksum="CFA09E66AF53093A" modified="2016-06-08" version="1">MASPARHPEALRQEAGLLSGMAQLGAIAAVTVSFVAAAFFSAIHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSFKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLIQNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLIIQAVRVTKPNIPETIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKIAQVAEITYGQKVMEKETEKRISEIEDAAFLAREKAKADAECYTALKMAEANKLKLTPEYLQLMKYKAIAANSKIYFGKDIPNMFMDHAGSHGKLAKGLVEEMRDQLGAGAPEDFYKKKVKLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCJ4</accession>
    <name>A0A151NCJ4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003532">
        <property type="protein sequence ID" value="KYO34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCJ4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13686" checksum="773F840903B143C8" modified="2016-06-08" version="1">MTRDTFLDLLEQQDTTMWQPSPTDTQLAITLMKLASLHYVGHLFGMAKVSAGEAILEVCITLQDVLGHTMLCVHNPLAVVVGFQVLGFPQCIRALDGTHIPITCLLHGDHPYYSRRSFHSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ND05</accession>
    <name>A0A151ND05_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CAVP-target protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0017035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003361">
        <property type="protein sequence ID" value="KYO34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ND05"/>
    <dbReference type="STRING" id="8496.A0A151ND05"/>
    <dbReference type="KEGG" id="amj:109284021"/>
    <dbReference type="eggNOG" id="ENOG502QWJ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2152335at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055013">
        <property type="term" value="P:cardiac muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF8">
        <property type="entry name" value="SPEG NEIGHBOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="163"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="254" mass="27441" checksum="B132E9344A8D415D" modified="2016-06-08" version="1">MSKAAPKAAPPAPKAAPPAAKPAPKKGATPAPPGFSLDINDPQVQNAAIRIQASYRGHRSRKELREKGPPRVLEGLKDTMLIEGSAAKLSCRISAFPDPFIRWSKDGVELKDGPKHRYIFEDPDIVALVVRDGGLADLGRYTVSVKNPFGECFDSARILVEVPAKIEKGPESTKAKVGSKVMLTALISGQPEPEVGWAKDGQDIEEDDRVFYDIGSDSTTLTIRSVEKGDAGKYEVFVENSLGMDESFARLDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDQ7</accession>
    <name>A0A151NDQ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0018509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003238">
        <property type="protein sequence ID" value="KYO34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDQ7"/>
    <dbReference type="STRING" id="8496.A0A151NDQ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF47">
        <property type="entry name" value="KALLIKREIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="132" mass="14433" checksum="0223CAB09F051F93" modified="2016-06-08" version="1">MRMGDYSLSKNEGTEQCITSAKAFPHPNYNSNTHDSDIMLLKLANPIHITEYVDYVNISTACPALGISCLVSGWGTTDSPEAIKESKARSHHAQFPGLTSMFLTHLIPAKIMEFAKEDSLIEGTIMACRVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NE62</accession>
    <name>A0A151NE62_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NE62"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10736" checksum="03E0D0A71693660F" modified="2016-06-08" version="1">MSWTNRRTDAPSPDFGLSQSMEGSLSACIDCDSHRLYYIWHGDQVKTAAIWEQDPGVPARLRELGQGVQAELGSFVLDKRLPVMPQEMRLYLTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEQ2</accession>
    <name>A0A151NEQ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0007875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEQ2"/>
    <dbReference type="STRING" id="8496.A0A151NEQ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13184">
        <property type="entry name" value="FERM_C_4_1_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17203">
        <property type="entry name" value="FERM_F1_EPB41L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000002">
        <property type="entry name" value="Erythrocyte protein band 4.1-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030691">
        <property type="entry name" value="Band4.1-L3_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008379">
        <property type="entry name" value="Band_4.1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007477">
        <property type="entry name" value="SAB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF20">
        <property type="entry name" value="BAND 4.1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05902">
        <property type="entry name" value="4_1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04382">
        <property type="entry name" value="SAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002304">
        <property type="entry name" value="Membrane_skeletal_4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="8">
        <location>
            <begin position="110"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="779"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="694"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="964" mass="107738" checksum="49A0D3E45390C2E1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGN3</accession>
    <name>A0A151NGN3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Neural cell adhesion molecule 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NCAM2</name>
        <name evidence="19" type="ORF">Y1Q_0010133</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGN3"/>
    <dbReference type="STRING" id="8496.A0A151NGN3"/>
    <dbReference type="eggNOG" id="KOG3510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05865">
        <property type="entry name" value="IgI_1_NCAM-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05869">
        <property type="entry name" value="IgI_NCAM-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000086">
        <property type="entry name" value="Neural cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000173">
        <property type="entry name" value="Neural cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000151">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000137">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000149">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000159">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000221">
        <property type="entry name" value="neural cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009138">
        <property type="entry name" value="Neural_cell_adh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF239">
        <property type="entry name" value="NEURAL CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01838">
        <property type="entry name" value="NCAMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586050" description="Neural cell adhesion molecule 1" evidence="16">
        <location>
            <begin position="20"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="116"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="212"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="308"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="406"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="499"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="600"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="755"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="863"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="931"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="758"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="872"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="904"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="936"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1097"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO35685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1109" mass="119507" checksum="5AE81C04517042D2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGQ0</accession>
    <name>A0A151NGQ0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dixin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Coiled-coil protein DIX1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">DIX domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DIXDC1</name>
        <name evidence="22" type="ORF">Y1Q_0010150</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DIXDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGQ0"/>
    <dbReference type="STRING" id="8496.A0A151NGQ0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21213">
        <property type="entry name" value="CH_DIXDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000054">
        <property type="entry name" value="Dixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000003">
        <property type="entry name" value="Dixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF22">
        <property type="entry name" value="DIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 17" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="20">
        <location>
            <begin position="57"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DIX" evidence="21">
        <location>
            <begin position="643"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="597"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="379"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO35705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="726" mass="81482" checksum="CA01A44F4669AB04" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHH0</accession>
    <name>A0A151NHH0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PTPN22</name>
        <name evidence="11" type="ORF">Y1Q_0010554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03002960">
        <property type="protein sequence ID" value="KYO36200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHH0"/>
    <dbReference type="STRING" id="8496.A0A151NHH0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050868">
        <property type="term" value="P:negative regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14602">
        <property type="entry name" value="PTPc-N22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047170">
        <property type="entry name" value="PTN12/18/22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047253">
        <property type="entry name" value="PTN22_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983">
        <property type="entry name" value="TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="203"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO36200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="579" mass="65417" checksum="99AFDB73C228AAF7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIH0</accession>
    <name>A0A151NIH0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0024304</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel subunit alpha-2/delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIH0"/>
    <dbReference type="STRING" id="8496.A0A151NIH0"/>
    <dbReference type="eggNOG" id="KOG2353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01463">
        <property type="entry name" value="vWA_VGCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000012">
        <property type="entry name" value="Calcium channel, voltage-dependent, alpha2/delta subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000007">
        <property type="entry name" value="Calcium voltage-gated channel auxiliary subunit alpha2delta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF59">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="222"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO36606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1071" mass="121221" checksum="C8CE33AB6417D880" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIS2</accession>
    <name>A0A151NIS2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0024368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIS2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="150" mass="16737" checksum="D1168E1829A0480E" modified="2016-06-08" version="1">MTMAEMESMEGWKQEAFTWQLRINEVEERVAHLQRELEIVNFIIEQPEVKVAALELCLQSGKKKGGSKEVGCLIAAETEKFEHWNSLSRIRLRKAKSVLTEPVQVAASLKANIGQLQLLFNGAGEGDAAIKKARYEETLLTARLPLCGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK61</accession>
    <name>A0A151NK61_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM222</name>
        <name evidence="2" type="ORF">Y1Q_0023089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002882">
        <property type="protein sequence ID" value="KYO37069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK61"/>
    <dbReference type="STRING" id="8496.A0A151NK61"/>
    <dbReference type="eggNOG" id="KOG3150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="174" mass="19588" checksum="78E35033C7009E7D" modified="2016-06-08" version="1">MKPFGGGGAGLDAERGRFPYCVVWTPIPVLTWLFPIIGHMGICTSAGIIRDFAGPYYVSEDNMAFGRPVKYWKLDPNKVYSTSPNAWDTAVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYDNSSSWNMVKLCFFSLLYGKYVSIGGFVKTWLPFVLFLGAILTVALTLHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKN3</accession>
    <name>A0A151NKN3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CHEK2</name>
        <name evidence="9" type="ORF">Y1Q_0013176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AKHW03002750">
        <property type="protein sequence ID" value="KYO37320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKN3"/>
    <dbReference type="STRING" id="8496.A0A151NKN3"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22666">
        <property type="entry name" value="FHA_CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14084">
        <property type="entry name" value="STKc_Chk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000354">
        <property type="entry name" value="Serine/threonine-protein kinase Chk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000255">
        <property type="entry name" value="serine/threonine-protein kinase Chk2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="116"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO37320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="433" mass="49199" checksum="EF822EFC372206CE" modified="2016-06-08" version="1">MSDCVNDECWFGRDKSCDYSFSRIGLSETGFYQNYSKKHFRIFKETGPQNSCVAYIEDHSVNGTFVNKELIGRGKRLPLTHNSEIALSVQSNKVFVFSDLMVDDQSGYPREFREKYIMSKTLGSGACGEVKLAFEKATCNKVAVKIINKRRFMTAAVREADPVFNVNTEIEILKKINHSVVAEDYYIILELMEGGELYDRVSRPIKMKEATCKLYFYQMLLAVKYLHDNGIIHRDLKPENVLLSSSEENCLIKITDFGQSKILGETSLMKTLCGTPTYLAPEVLNSLGTEGYSRAVDCWSLGVILFVCLCGYPPFNEQNTKLSLKEQITQGKYTFIPKEWKHVSNTALDLVKKLLVVDPNKRLTTEEALGHPWLQDEAVKDTFKQLQKQIGFSLDSSQASKVPTTMRKRLHDKEEEPGSPKRAFPSTSFKKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKU4</accession>
    <name>A0A151NKU4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKU4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="208" mass="23787" checksum="DB290B53FE689C1C" modified="2016-06-08" version="1">MSKLEDSYIIAENLVISVRRSRIPIQRSSPARGVCPAVAAWPCSRGIFRSTQAQLYHLNRCYEEQLSEQDHSEAESAQLFHSKDHPNSELKGKVCEIKDTFPEKLASQRDMSSNSSMAMLRRELLICPGSALSSLQVLCHICLIGKHEMLQHDHSFFLPLPSDQVKTKQKYCIKELAKFSSNYQGSWFSLIKKKSPIFRFQYVETKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP87</accession>
    <name>A0A151NP87_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP87"/>
    <dbReference type="STRING" id="8496.A0A151NP87"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF84">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28764" checksum="B42D4047868EB6C7" modified="2016-06-08" version="1">MGSYTHRDHHSCGQNKKRLNFGTWNVRTLINNPKSDCPEKQTAIVVQELARHNINIAAVSKTQLAEEGQLREVSRGYTFFWKRKPNHDPCIHRVGFVFRNKIADILPELSLSVNERLMTLHLHFSQNQRATVISAFAPTLHSDEEVKEGFYSDFDNILASISRDNKVILLGDFNTWVGRDHEIWSRTISKSGVGKANANGILLLTKCAQHGLIITNTVFCQKDQLKTMWRHPRSEHWHILDYIIIQGRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQ06</accession>
    <name>A0A151NQ06_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0023889</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002411">
        <property type="protein sequence ID" value="KYO38922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQ06"/>
    <dbReference type="STRING" id="8496.A0A151NQ06"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000009">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000017">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000373">
        <property type="entry name" value="Ventral neural cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF272">
        <property type="entry name" value="CADHERIN-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586270" description="Cadherin domain-containing protein" evidence="13">
        <location>
            <begin position="19"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="143"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="274"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="389"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO38922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="629" mass="66932" checksum="CAEB6E505F40197D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQJ7</accession>
    <name>A0A151NQJ7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CUGBP Elav-like family member 2 isoform D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CELF2</name>
        <name evidence="11" type="ORF">Y1Q_0023451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQJ7"/>
    <dbReference type="STRING" id="8496.A0A151NQJ7"/>
    <dbReference type="eggNOG" id="KOG0144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12631">
        <property type="entry name" value="RRM1_CELF1_2_Bruno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12634">
        <property type="entry name" value="RRM2_CELF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000013">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000015">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000016">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034196">
        <property type="entry name" value="CELF1/2_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034198">
        <property type="entry name" value="CELF1/2_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="440"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO38765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="528" mass="56405" checksum="2106926A1B304A0E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSP8</accession>
    <name>A0A151NSP8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Unconventional myosin-XVIIIb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MYO18B</name>
        <name evidence="10" type="ORF">Y1Q_0018796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NSP8"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016461">
        <property type="term" value="C:unconventional myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01386">
        <property type="entry name" value="MYSc_Myo18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000011">
        <property type="entry name" value="unconventional myosin-XVIIIa isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036064">
        <property type="entry name" value="MYSc_Myo18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057772">
        <property type="entry name" value="SH3_Myo18a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF8">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XVIIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24556">
        <property type="entry name" value="SH3_Myosin-XVIIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="411"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1918"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1975"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2283"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1229"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1292"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1529"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1714"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1853"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1945"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1975"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1998"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2285"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2299"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="500"/>
            <end position="507"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO39783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2349" mass="262098" checksum="42A1EB8F02DDCB4D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTM8</accession>
    <name>A0A151NTM8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002051">
        <property type="protein sequence ID" value="KYO40237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTM8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="306" mass="31868" checksum="4087CF62D3CEBDCB" modified="2016-06-08" version="1">MSCVEYEGGPEAAVVLSWCWVEMPFFQGWAVAGMRGSTAGSPPPQALDSLAPGRPLQDAGMHGAWLEAQARGEGAALPAWGTSPPCWQVRAPLDWDLACRAGQDPITQLPSGPWHPEISAGSQLEEDSGCGEAEAQELLLAGLDDEWGSQGNSILLPGTDATLFLPASPHGTGTASGSKRANPGGCSPQPRKKQRGEAQPGAAQLLGLPGGGALLAPPVLPPLPLPAWPGPHQPAWPVRSRLVPHGHLALLLPIQLPSPPCQRQQAPATPLPPQHPSARPDSPSALLNTCLLLRALRWSLTTTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU28</accession>
    <name>A0A151NU28_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">YEATS domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">YEATS2</name>
        <name evidence="14" type="ORF">Y1Q_0013246</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, SGF29 and DR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001930">
        <property type="protein sequence ID" value="KYO40431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019341682.1">
        <property type="nucleotide sequence ID" value="XM_019486137.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059586892.1">
        <property type="nucleotide sequence ID" value="XM_059730909.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059586893.1">
        <property type="nucleotide sequence ID" value="XM_059730910.1"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NU28"/>
    <dbReference type="GeneID" id="102569700"/>
    <dbReference type="KEGG" id="amj:102569700"/>
    <dbReference type="CTD" id="55689"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16907">
        <property type="entry name" value="YEATS_YEATS2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000001">
        <property type="entry name" value="YEATS domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055127">
        <property type="entry name" value="YEATS2_3HBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22951">
        <property type="entry name" value="3HBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="YEATS" evidence="13">
        <location>
            <begin position="200"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="790"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO40431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1403" mass="149757" checksum="FE201DE003429D52" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUA2</accession>
    <name>A0A151NUA2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Microtubule-associated proteins 1A/1B light chain 3C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0006458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002115">
        <property type="protein sequence ID" value="KYO39995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUA2"/>
    <dbReference type="STRING" id="8496.A0A151NUA2"/>
    <dbReference type="eggNOG" id="KOG1654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO39995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8306" checksum="1F376427DF2F173C" modified="2016-06-08" version="1">MSPHERRGAFKQRKSFASRQREVAAVRAKFPNKLPVILERYPREKALPVLDRTKFLVPQELTMGQFVAIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUP7</accession>
    <name>A0A151NUP7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0008987</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Choline transporter.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>choline(out) + n H(+)(in) = choline(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:75463"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ethanolamine(out) + n H(+)(in) = ethanolamine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:75467"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Cell membrane</location>
            <topology evidence="2 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001975">
        <property type="protein sequence ID" value="KYO40299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUP7"/>
    <dbReference type="STRING" id="8496.A0A151NUP7"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF34">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO40299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="716" mass="81086" checksum="C60CD053F35CE783" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUR1</accession>
    <name>A0A151NUR1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NTPase KAP family P-loop domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NKPD1</name>
        <name evidence="9" type="ORF">Y1Q_0009458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001913">
        <property type="protein sequence ID" value="KYO40661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUR1"/>
    <dbReference type="STRING" id="8496.A0A151NUR1"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000180">
        <property type="entry name" value="Zinc finger protein 689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001442">
        <property type="entry name" value="zinc finger protein 696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052754">
        <property type="entry name" value="NTPase_KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22674:SF4">
        <property type="entry name" value="NTPASE KAP FAMILY P-LOOP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22674">
        <property type="entry name" value="NTPASE, KAP FAMILY P-LOOP DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="614"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO40661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="741" mass="84434" checksum="FAE3A6771DDC034D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVH6</accession>
    <name>A0A151NVH6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001812">
        <property type="protein sequence ID" value="KYO40911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVH6"/>
    <dbReference type="STRING" id="8496.A0A151NVH6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="156" mass="16793" checksum="AB40E338FAF939BD" modified="2016-06-08" version="1">MVLTFPPSSHPLGILTRENRCLENMENLLQNSNFWILRLPPGTKGERDRIDLEALRSWQDLICFAFSREQMIPAIALQIYPSLRADSPCPAGSRQAGAAVLPPPGAGRCGQGAESRHGRAGKRSIPGLQLGITPGQPCRSCSCPAPGEGHCARPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVR0</accession>
    <name>A0A151NVR0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001886">
        <property type="protein sequence ID" value="KYO40679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVR0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="259" mass="28735" checksum="40FE5F4F3FFCE819" modified="2016-06-08" version="1">MKGDAREYHCTASRGNNPVLSQEKIRGDGVRRASKEVKPGSSLALALRNLRRKAKHARAMWKKTLGKPKPASHDGRAAQPASSQMSHARGTTRRTLLGRRGHEHDQSENPVKRQCSFLETVAKKDAVSKGGLEVAPAPSQVSSSHPVYSPFQLWENMCLLAKKARNARELLPMYPGFPFRVQQNKSLLPRLGRNFHHLLPRVETAPMLPSLENSQGRKRVYQGGRRDAPAEQSACCPVGVLDPLIQGAWLSPQRDLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVX0</accession>
    <name>A0A151NVX0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dynein intermediate chain 2, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DNAI2</name>
        <name evidence="13" type="ORF">Y1Q_0007713</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001796">
        <property type="protein sequence ID" value="KYO40938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVX0"/>
    <dbReference type="STRING" id="8496.A0A151NVX0"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001017">
        <property type="entry name" value="Dynein axonemal intermediate chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000371">
        <property type="entry name" value="dynein intermediate chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="551"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO40938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="625" mass="70913" checksum="DA6956FBA4A72586" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX33</accession>
    <name>A0A151NX33_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetylserotonin O-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Hydroxyindole O-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ASMT</name>
        <name evidence="14" type="ORF">Y1Q_0022545</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.4" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03001669">
        <property type="protein sequence ID" value="KYO41139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006269117.1">
        <property type="nucleotide sequence ID" value="XM_006269055.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX33"/>
    <dbReference type="STRING" id="8496.A0A151NX33"/>
    <dbReference type="GeneID" id="102575782"/>
    <dbReference type="KEGG" id="amj:102575782"/>
    <dbReference type="CTD" id="438"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017096">
        <property type="term" value="F:acetylserotonin O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030187">
        <property type="term" value="P:melatonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000358">
        <property type="entry name" value="Acetylserotonin O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000146">
        <property type="entry name" value="Acetylserotonin O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0471">Melatonin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="13">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="12">
        <location>
            <begin position="118"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO41139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="346" mass="39202" checksum="41CD23DFA0696351" modified="2016-06-08" version="1">MDSAEDLNYPQILFQYNHGFFFSKTMFTACELGVFDLLLESEEPLSSDVIAGRLGTSTTGMERLLDTCVGLKLLRVELNSEGVFYRNTELSNLYLAKASPKSLYHNMMYYSKTVYLCWHYLTDAVREGKNQYERAFGISSKDLFGAVYRSEEEMIKFMYGLNEIWSICGRDVIAAFDLSPFTHIYDLGGCAGGLAQECISLYPNSTVTIYDLPKVAQVAKERFIPPEEHRIMFHEGDFFKDPVPEADLYILARILHDWPDDKCMHLLEKIHKVCKPGGGVLVVETLLNEDKSGPLDTQVYSLNMLVQAEGKEKTSTEYSNLLRAAGFKEVQVKKTGKLYDAILGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXJ4</accession>
    <name>A0A151NXJ4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Interleukin-1 receptor type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">IL1R2</name>
        <name evidence="15" type="ORF">Y1Q_0006223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006269780.1">
        <property type="nucleotide sequence ID" value="XM_006269718.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXJ4"/>
    <dbReference type="STRING" id="8496.A0A151NXJ4"/>
    <dbReference type="GeneID" id="102558781"/>
    <dbReference type="KEGG" id="amj:102558781"/>
    <dbReference type="CTD" id="7850"/>
    <dbReference type="eggNOG" id="ENOG502QVTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9881731at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019966">
        <property type="term" value="F:interleukin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004910">
        <property type="term" value="F:interleukin-1, type II, blocking receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000188">
        <property type="entry name" value="Interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004074">
        <property type="entry name" value="IL-1_rcpt_I/II-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004077">
        <property type="entry name" value="IL-1_rcpt_II-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041416">
        <property type="entry name" value="IL-1RAcP-like_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF3">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18452">
        <property type="entry name" value="Ig_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01539">
        <property type="entry name" value="INTRLEUKN1R2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01536">
        <property type="entry name" value="INTRLKN1R12F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="172"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO41400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="409" mass="46681" checksum="3089405928367A18" modified="2016-06-08" version="1">MQTHRFQDAVSHFSHSHFLWTKTPALLLAISFCTMDASAFRIQPVKSIEQCQDHTVYFKHYFVLRGEAVILKCSSLSHGSLAFSDLSLNLTWHKNDSQPMISGEDKEQRIQAKGDTLWFLPASLEDTGVYVCTRRNSSYCAKVSIHLTVVEKTAAHAISYMQKLFTFTSGKLVCPDLEDFIDKKADLELKWYKDSVPLGEDNKKYIRLKETTSLIISSVLPEDSGYYTCKMSFTYEGTQYPVTRTIQLQTVETEKRNTPVIVYPDQKTTLAVPGYKMIIPCKVFIGLSRDSYTIVRWLANDTNIDTMYKDDRVTVGEHQEIVENGENFIEVPLIFDPVREVDFYTDFKCLAQNSVGYQVLPTRVKEEAISFSWYIAMIPVALACLLVGGLLIHKCWIQRADKGYMIAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXX5</accession>
    <name>A0A151NXX5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0006299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXX5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9287" checksum="69A92455E49D8EF9" modified="2016-06-08" version="1">MTGKRVREKRRGGRRVCAGKDKQTSSKPIGGKKESQKLIQAETEKNGSNISGKHFLYKVSSTVSIKIGDTLLTVAMETVFVFGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY28</accession>
    <name>A0A151NY28_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 25 member 44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC25A44</name>
        <name evidence="8" type="ORF">Y1Q_0004489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001603">
        <property type="protein sequence ID" value="KYO41792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY28"/>
    <dbReference type="STRING" id="8496.A0A151NY28"/>
    <dbReference type="eggNOG" id="KOG0765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042164">
        <property type="entry name" value="SLC25A44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314:SF2">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="136"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="248"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO41792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="342" mass="37409" checksum="A1160D51D8C0EEBC" modified="2016-06-08" version="1">MLTLTRESTGGDTLGPGGQDLGGQQQPGAQNDQEKAALVAHRFSSSASSLEGSHAGQTKHPDHRMGTSGQEEVLCVQKGKSLYNGTFDAFVKILRTEGASGLYRGFLVNTFTLISGQCYVTTYELTRKYVACYSNSNTVKSLVAGGSASLVAQSITVPIDIVSQHLMMQRKGETMGRFRIQNSDCKRALVFGQTKEVIVQIFKADGLRGFYRGYVASLLTYIPNSAVWWPFYHFYAEQLSRLTPKDCPHLLLQAISGPLAAATASTLTNPMDVIRARVQVEGKNSIILTFKQLMAEEGPWGLTKGLSARIISATPSTIVIVVGYETLKKLSLRPEFMDSRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY35</accession>
    <name>A0A151NY35_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SMG5</name>
        <name evidence="10" type="ORF">Y1Q_0004483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001603">
        <property type="protein sequence ID" value="KYO41786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY35"/>
    <dbReference type="STRING" id="8496.A0A151NY35"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09884">
        <property type="entry name" value="PIN_Smg5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000017">
        <property type="entry name" value="protein SMG5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF7">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="9">
        <location>
            <begin position="829"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO41786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="990" mass="111572" checksum="90ECA25EB245474C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5A4</accession>
    <name>A0A151P5A4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gastrokine-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GKN1</name>
        <name evidence="4" type="ORF">Y1Q_0013956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000870">
        <property type="protein sequence ID" value="KYO44150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5A4"/>
    <dbReference type="STRING" id="8496.A0A151P5A4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051772">
        <property type="entry name" value="Gastrokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16483">
        <property type="entry name" value="GASTROKINE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO44150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="200" mass="21577" checksum="1484045A1C89D9EA" modified="2016-06-08" version="1">MFASSQPTSTGQSPSNLFDQRTTLATFNISCYVSNEKLMEALEIQTSKSAMLTVVAKMAVVVGLLDKIHFQIVIACLLGVLLAPVLANNGYVATRILSKKACIVSKMNKNAMPDSALFPQLIKERKSAGLQAPPAKELLCIVSKTTASDLTPFGPSIHAQCRGVPTYIAHQVQGPNFFHPECFTADLGFTHINYCADTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5H9</accession>
    <name>A0A151P5H9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Secernin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SCRN2</name>
        <name evidence="3" type="ORF">Y1Q_0012086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5H9"/>
    <dbReference type="STRING" id="8496.A0A151P5H9"/>
    <dbReference type="eggNOG" id="ENOG502QPIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.10:FF:000001">
        <property type="entry name" value="Secernin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF16">
        <property type="entry name" value="SECERNIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO44316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="476" mass="52876" checksum="E82B55D6CE57DCEE" modified="2016-06-08" version="1">MGVGPNIRHLDTFPCFSGPLQGWHERMRFLSSSLEAKSTGLRMTVLHRMAEHIPPAPSSCDCFVALPPATASQAVIFGKNSDRPSNEVQEVVYFPAAAYPNGTKVQCTYIEVDQAEKTHAVILSRPAWLWGAEMGANEHGVCIGNEGVWTKEPVGEEEALLGMDLVRLGLERGRSAHEAVQVITTLLERYGQGGSCKEEPTPFIYHNTFLLADRTEAWVLETAGLYWAAEKIREGARNISNQLSIGTDIAAEHMKLRHHAQSQGWWSGDGEFNFAEIFSLSHQPVRMEAAKARYCAGRELLQQHAGHITVETIMGILRDKASGICVDSEGFCTTGSMVSILPQDPALPCIHFFTATPDPSRSVFKPFVFVANVTPVPQVRSPSFGAEDPVKKVPRFQSRVDRRHELYREHQAAVKLMQTGQERGQKLQQTMQDLEMQGLEATRRSNSTNKPHSSLEYFRQMQAPCRCPSPDSSPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P612</accession>
    <name>A0A151P612_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0023103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000760">
        <property type="protein sequence ID" value="KYO44498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P612"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19760">
        <property type="entry name" value="Bbox2_TRIM4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO44498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="276" mass="31930" checksum="55C0FC4EE7D29EC3" modified="2016-06-08" version="1">MTSEESGDTFFCPSYRARFHRGSFQPYSKQRNLVEKVKQQCLKPGKEQMGNQCEKHQENFKLFCEADGEAICVVCRESQDHCSHTVVPIEEAASHYKDKVEQQRERIKSDCEKLHCFVCEEVQLLLQRREEQERETLKSLEENVAQLSKQSSSLHKLISEREKKSLQAPAELLKDVKRTLDRCCVFFFPLPSRFLLGAWQEYLLGRAGLSNNRGYVPLRSKNVELQVAKAVFTELKTVFSIPGMVEMLRKFRSTWEHVRLIGSSNTCGNGDFIVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6K9</accession>
    <name>A0A151P6K9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000695">
        <property type="protein sequence ID" value="KYO44653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6K9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="8217" checksum="3AC3C6D282A504F9" modified="2016-06-08" version="1">MTSAQWKMDAKVVVATILARTFAVTLRRTFESRKVQGEHNEEFKNNFDSNVFAREKHLLYEIQWAKDMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6S6</accession>
    <name>A0A151P6S6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polycystic kidney disease and receptor for egg jelly-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PKDREJ</name>
        <name evidence="11" type="ORF">Y1Q_0016875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P6S6"/>
    <dbReference type="eggNOG" id="KOG3599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000016">
        <property type="entry name" value="Polycystin family receptor for egg jelly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018785">
        <property type="entry name" value="CDPF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF185">
        <property type="entry name" value="POLYCYSTIN FAMILY RECEPTOR FOR EGG JELLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10170">
        <property type="entry name" value="C6_DPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01995">
        <property type="entry name" value="UPF0595"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1407"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1615"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1647"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1826"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1864"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1961"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="10">
        <location>
            <begin position="443"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="9">
        <location>
            <begin position="1452"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1678"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1718"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1767"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1718"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1783"/>
            <end position="1797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO44768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2253" mass="253671" checksum="0A21D95F01F55030" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAM4</accession>
    <name>A0A151PAM4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAM4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="10534" checksum="2E003335DD7DF115" modified="2016-06-08" version="1">MKRRASLGCGEPECQRGAEPDCAAEDQGGQGGQITTRPRPNNVDTICEAWGMVKAEGKVFPTFGLKKGVLKKIIFSLLVIMQTIIHCDINTICHFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PD18</accession>
    <name>A0A151PD18_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin-related protein 3B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0014515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PD18"/>
    <dbReference type="STRING" id="8496.A0A151PD18"/>
    <dbReference type="KEGG" id="amj:102564093"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000315">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000803">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000002">
        <property type="entry name" value="actin-related protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47549" checksum="0F76A68D995335E8" modified="2016-06-08" version="1">MARALPACVVDGGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVGDQAQRRVMKGVDDLDFFIGDEAIDKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAVKEKYCYICPDIVKEFAKYDVDPRKWIKQYTGINAINKKKFIIDVGYERFLGPEIFFHPEFANPDFMDSISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPVEVQVITHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGC6</accession>
    <name>A0A151PGC6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar and coiled-body phosphoprotein 1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NOLC1-1</name>
        <name evidence="3" type="ORF">Y1Q_0001973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGC6"/>
    <dbReference type="STRING" id="8496.A0A151PGC6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="661"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO48177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="841" mass="87535" checksum="475C924B70A1E1CC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHI3</accession>
    <name>A0A151PHI3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bromodomain-containing protein 4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BRD4</name>
        <name evidence="13" type="ORF">Y1Q_0017128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the BET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000209">
        <property type="protein sequence ID" value="KYO48364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PHI3"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031354">
        <property type="entry name" value="BRD4_CDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF143">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17105">
        <property type="entry name" value="BRD4_CDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="141"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="431"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="12">
        <location>
            <begin position="665"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="524"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="740"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="826"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="945"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="966"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1205"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1219"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1281"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1330"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO48364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1369" mass="154109" checksum="9651314929DC4B60" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHS6</accession>
    <name>A0A151PHS6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein POC5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein of centriole 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">POC5-1</name>
        <name evidence="13" type="ORF">Y1Q_0003989</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHS6"/>
    <dbReference type="STRING" id="8496.A0A151PHS6"/>
    <dbReference type="eggNOG" id="ENOG502QUKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042462">
        <property type="term" value="P:eye photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033351">
        <property type="entry name" value="POC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28618:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN POC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="416"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO48568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="608" mass="67862" checksum="AB6392212890E661" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PI09</accession>
    <name>A0A151PI09_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cell cycle checkpoint protein RAD17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RAD17</name>
        <name evidence="16" type="ORF">Y1Q_0004035</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation. Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites. May also serve as a sensor of DNA replication progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within the 9-1-1 (RAD1-RAD9-HUS1) complex. Interacts with RAD9B, POLE, SNU13 and MCM7. DNA damage promotes interaction with ATR or ATM and disrupts interaction with the 9-1-1 (RAD1-RAD9-HUS1) complex. Interacts (when phosphorylated) with NBN; promoting recruitment of the MRN complex to DNA damage sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270037.1">
        <property type="nucleotide sequence ID" value="XM_006269975.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PI09"/>
    <dbReference type="STRING" id="8496.A0A151PI09"/>
    <dbReference type="GeneID" id="102560852"/>
    <dbReference type="KEGG" id="amj:102560852"/>
    <dbReference type="CTD" id="5884"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PI09"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000714">
        <property type="entry name" value="cell cycle checkpoint protein RAD17 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018324">
        <property type="entry name" value="Rad17/Rad24_fun/met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00602">
        <property type="entry name" value="rad24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="15">
        <location>
            <begin position="406"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="647"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO48633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="696" mass="78476" checksum="86D0BD6E16B1239A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ54</accession>
    <name>A0A151PJ54_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho guanine nucleotide exchange factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARHGEF17</name>
        <name evidence="7" type="ORF">Y1Q_0020591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000111">
        <property type="protein sequence ID" value="KYO49097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PJ54"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000025">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000206">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000434">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF15">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="672"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1232"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1593"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1596"/>
            <end position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO49097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1659" mass="181133" checksum="8558B039B4958A35" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2H1</accession>
    <name>A0A151M2H1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin-like protein KIF25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KIF25</name>
        <name evidence="7" type="ORF">Y1Q_0009163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014452207.1">
        <property type="nucleotide sequence ID" value="XM_014596721.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2H1"/>
    <dbReference type="STRING" id="8496.A0A151M2H1"/>
    <dbReference type="GeneID" id="102576110"/>
    <dbReference type="KEGG" id="amj:102576110"/>
    <dbReference type="CTD" id="3834"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M2H1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000131">
        <property type="entry name" value="Kinesin family member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF63">
        <property type="entry name" value="KINESIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="175"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="271"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="589" mass="66031" checksum="84077F16660E2AAC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2Q4</accession>
    <name>A0A151M2Q4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-dependent metalloprotease SPRTN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Protein with SprT-like domain at the N terminus</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SPRTN</name>
        <name evidence="19" type="ORF">Y1Q_0009218</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Spartan family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274559.1">
        <property type="nucleotide sequence ID" value="XM_006274497.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2Q4"/>
    <dbReference type="STRING" id="8496.A0A151M2Q4"/>
    <dbReference type="GeneID" id="102563379"/>
    <dbReference type="KEGG" id="amj:102563379"/>
    <dbReference type="CTD" id="83932"/>
    <dbReference type="eggNOG" id="KOG3931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000331">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="18">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO18794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="495" mass="55659" checksum="559B1894E3891200" modified="2016-06-08" version="1">MDADFLMALHLQAQWEAGEEEKEVAAGARPEPPARPLSVVDESWELLDPSPDVHGLFVQFNQELFWGRLAAVEVSWSSRMTLCAGVCSYEGRGGICSIRLSEPLLKLRPRKDLVETLLHEMIHALLFVTNDDRDRDSHGPEFRKHMRRINRLTGANVTIHHNFHDEVDLYRQHWWRCNGPCQNKKPYFGYVKRSMNRAPSARDFWWVEHQESCGGTFTKVKEPENYSKKGKEKTQPGKLSSSKPSDDKGKKYGGDTQSLIPFSGNGYRLGGTDSGSSEKITSSITTIKSKEILSSPHPSAARSTRPVPKNEIKFENSPRSNALFPLKFDDTSHENKFASEREFPKLSVANTKVYKNVNGSPVKISAFIGGKSNRLSTNAKWALPSSNETPRQIFFEQTPRAWVASQGNKSLETVGMPKKRPKMEDKTAFENFFIKRERMDSSFRTSTPIKSLAESTVSSASTNSAVNQVKNVSCPVCQTEVLESKINEHLDSCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2Z9</accession>
    <name>A0A151M2Z9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein FAM26D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FAM26D</name>
        <name evidence="10" type="ORF">Y1Q_0018867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CALHM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2Z9"/>
    <dbReference type="STRING" id="8496.A0A151M2Z9"/>
    <dbReference type="eggNOG" id="ENOG502RKQ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029569">
        <property type="entry name" value="CALHM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261:SF5">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14798">
        <property type="entry name" value="Ca_hom_mod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO18882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="192" mass="21926" checksum="23116D44AF34564D" modified="2016-06-08" version="1">MSEFVSVNHYKAFINITTKEHKKILAAFPCSHLVPPELSRAKDEAILLLKYQSQVAGWFLIAGVAITVFLSYCLARCLSPLSFLHLKYWASYVRNEQKLFEEAADLHSRLYATQHIKKFFGLVPGSKDLREIRIPSCKDWRSISGVAVLRIVDEEHYDYSLLHDWAVNSSTNGKYFKIEESSSKNSEPPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M309</accession>
    <name>A0A151M309_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KPNA5</name>
        <name evidence="10" type="ORF">Y1Q_0018874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258982.1">
        <property type="nucleotide sequence ID" value="XM_006258920.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M309"/>
    <dbReference type="STRING" id="8496.A0A151M309"/>
    <dbReference type="GeneID" id="102563561"/>
    <dbReference type="KEGG" id="amj:102563561"/>
    <dbReference type="CTD" id="3841"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000001">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000013">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO18892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="539" mass="60400" checksum="38127093581E2931" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4Q4</accession>
    <name>A0A151M4Q4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDB1- and CUL4-associated factor 11</fullName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">WD repeat-containing protein 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">DCAF11</name>
        <name evidence="26" type="ORF">Y1Q_0017117</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with DDB1 and CUL4A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03006592">
        <property type="protein sequence ID" value="KYO19503.1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="PRK04210.1"/>
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        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL"/>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="GPROTEINBRPT"/>
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    </dbReference>
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        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
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        <property type="entry name" value="PEP carboxykinase-like"/>
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        <property type="entry name" value="WD40 repeat-like"/>
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        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="20" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 22" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="25">
        <location>
            <begin position="48"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="24">
        <location>
            <begin position="279"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="967"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="1015"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="1143"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="650"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1184"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00021767"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO19503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1208" mass="134708" checksum="DA8B70632F61A45E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5L9</accession>
    <name>A0A151M5L9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006531">
        <property type="protein sequence ID" value="KYO19813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5L9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="143" mass="16121" checksum="185E27C803D8B10C" modified="2016-06-08" version="1">MGEISVVETDSRIPKTDPGTVADPQQTASEPQAESLGVADNLIPKDCRGTRCLDGELSKRTHWGTYEMESLEGRVEDLEEEVHQPHTIRAHEGYIDGYCQTLLWKKDEEAKKMEGKVAIKKTGHQPTWNCMEDCHLRLRGMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M678</accession>
    <name>A0A151M678_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kininogen-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KNG1</name>
        <name evidence="8" type="ORF">Y1Q_0010626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M678"/>
    <dbReference type="STRING" id="8496.A0A151M678"/>
    <dbReference type="eggNOG" id="ENOG502RYAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030195">
        <property type="term" value="P:negative regulation of blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000002">
        <property type="entry name" value="Kininogen 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027358">
        <property type="entry name" value="Kininogen-type_cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050735">
        <property type="entry name" value="Kininogen_Fetuin_HRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814">
        <property type="entry name" value="FETUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814:SF12">
        <property type="entry name" value="KININOGEN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51647">
        <property type="entry name" value="CYSTATIN_KININOGEN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin kininogen-type" evidence="7">
        <location>
            <begin position="106"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin kininogen-type" evidence="7">
        <location>
            <begin position="226"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO20026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="426" mass="47695" checksum="1CC90911F72A4DCF" modified="2016-06-08" version="1">MLCCLFKSTNDDFMLLFFSQAGPGAQFFVKYRIRESTCAIGEGKAWQDCDYNAAVEAETGECTAEVYIDKTQKISNVSQECKIIPAAGKVTLSQAPCLGCYHPIPGNSLDLLPILRYAIRNFNKESQKSFLYEVGEIIKATRQVVAGWNYAVEYMVKETNCSKKEFQDLSPKCKPIFGGHVGNCVAKAFVDLSNTLVDVTQQCKFPVEETVPPPQMCPGCPKRIPNDSPELKEVLKASMEKYNSESDDDFYYKVESVFHSTVQVVAGKNYEIEFLIGKTNCSKSEVEKLNEDCKIVIPKISLQCTANIYVVPWKQEIFPQVNCSEVTPIIQARRPPGFTPFRSLMLHEIYPQTSPLQTAEEGKDPDKGPRENLGPGLENEDGQGDGCDHRVEDISKALYLIDFYTQFGSEQVGPMDLYAMHKGLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6P8</accession>
    <name>A0A151M6P8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-2 adrenergic receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Beta-2 adrenoreceptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ADRB2</name>
        <name evidence="26" type="ORF">Y1Q_0010740</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="22">Binds NHERF1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC. Interacts with USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4. Interacts with MARCHF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006277924.1">
        <property type="nucleotide sequence ID" value="XM_006277862.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6P8"/>
    <dbReference type="STRING" id="8496.A0A151M6P8"/>
    <dbReference type="GeneID" id="102567188"/>
    <dbReference type="KEGG" id="amj:102567188"/>
    <dbReference type="CTD" id="154"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5975661at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004941">
        <property type="term" value="F:beta2-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051380">
        <property type="term" value="F:norepinephrine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002025">
        <property type="term" value="P:norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006940">
        <property type="term" value="P:regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15957">
        <property type="entry name" value="7tmA_Beta2_AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000057">
        <property type="entry name" value="Beta-1 adrenergic receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002233">
        <property type="entry name" value="ADR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000332">
        <property type="entry name" value="ADRB2_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF21">
        <property type="entry name" value="BETA-2 ADRENERGIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01103">
        <property type="entry name" value="ADRENERGICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00562">
        <property type="entry name" value="ADRENRGCB2AR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12 23" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="19" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16 23 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18 23" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 23 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="25">
        <location>
            <begin position="41"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO20174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="392" mass="43776" checksum="FFAA6B71F1C3C5AD" modified="2016-06-08" version="1">MASARNASGLDSANSTTLSGDVWMVGMGVLMSLIVLAIVFGNVLVITAIARFQRLQTVTNCFITSLACADLVMGLAVVPFGASHIMLQMWQFGNFWCEFWTSLDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKGKARVVILVVWLVSALTSFLPIHMHWYQAESREALDCYEKATCCYFFTNQAYAIASSIISFYLPLVVMVFVYARVFQVAKQQLKKIDRFHVQGCQQPEHSGRPGRRASKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNIIPNYLYTLLNWLGYVNSAFNPLIYCRSPDFRFAFQELLCLRRSALKLYANGYSNSNGRSDFHEEDNGYHSGPDKPCELLCEGGAVAATGGLLHCQEIPGCPGMVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M933</accession>
    <name>A0A151M933_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arrestin domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARRDC4</name>
        <name evidence="9" type="ORF">Y1Q_0001337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M933"/>
    <dbReference type="STRING" id="8496.A0A151M933"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000005">
        <property type="entry name" value="Arrestin domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF16">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="8">
        <location>
            <begin position="96"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO21022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="323" mass="35897" checksum="EDA0E107EAAA0524" modified="2016-06-08" version="1">MPPLRAGGEENLILLAGRHEFPFSFQLPQEPLVTSFTGKYGSIQYCVKAVLERPVAPDQSVERELQVISHIDVSSPALLMPVLRSREKMVGCWLFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLVVPKAAIFQTQTYLASGKTKTFRQMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVEYTLAVYIHIPGAKKLMIEMPLVIGTIPCTGFSSRNSSVTSQFSMDMSWLALTMPEHPEAPPNYADVVSEEECCRHVPAYPQPIDCEEQLSCPMFAYIQEFRFQPPPLYSEIDPHPTDVEEIQPVSFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9B2</accession>
    <name>A0A151M9B2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LRP chaperone MESD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">LDLR chaperone MESD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mesoderm development candidate 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Mesoderm development protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MESDC2</name>
        <name evidence="13" type="ORF">Y1Q_0001404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MESD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9B2"/>
    <dbReference type="STRING" id="8496.A0A151M9B2"/>
    <dbReference type="GeneID" id="102568798"/>
    <dbReference type="KEGG" id="amj:102568798"/>
    <dbReference type="CTD" id="23184"/>
    <dbReference type="eggNOG" id="KOG4357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75833at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M9B2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000031">
        <property type="entry name" value="LDLR chaperone MESD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019330">
        <property type="entry name" value="MESD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600:SF2">
        <property type="entry name" value="LRP CHAPERONE MESD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17600">
        <property type="entry name" value="MESODERM DEVELOPMENT CANDIDATE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10185">
        <property type="entry name" value="Mesd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584899" description="LRP chaperone MESD" evidence="12">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO21104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="219" mass="24403" checksum="F3801DB3B2EC95D7" modified="2016-06-08" version="1">MAAGARGARLGLGLLLVVLCGACGAAGPGSRPAKKKDVRDYNDADMARLLEQWEKDDDIEEGDLPEHRRPSTPVDFSKIDPGKPESILKLTKKGKTLMMFVTVSGNPTEKETEELTSLWQGSLFNANYDVQRFIVGANRAIFMLRDGSYAWEIKDFLVNQERCADVTLEGQVYPGKGAEESEKVKNKTKPEKTKKKKDAEKKSKPLEDNNRASKEREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MA26</accession>
    <name>A0A151MA26_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase SETMAR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SETMARL</name>
        <name evidence="2" type="ORF">Y1Q_0001585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MA26"/>
    <dbReference type="STRING" id="8496.A0A151MA26"/>
    <dbReference type="PhylomeDB" id="A0A151MA26"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="357" mass="40571" checksum="781400B25057A648" modified="2016-06-08" version="1">MATQLAVCTKEEQRSVIRFLWAEGVPPSEIHRRIVAQYGKNCLAQRKVYEWVEKFKHGRTSVVDEPRAGRPNTATTEDNIAKVDAAVRASKRVSIPELVAEVGVSAGSIHAILHDHLNYQKVCARWVPKQLTDVHKRQRVEVCTQLLQHLQDEGEGFLSRIVTGDETWVHHYDPESKRQNMQWKCTSSPPPKKIHTQPPSGKVLLILFWDCLGPLLVHSMECAVTVNSSTYFHVLQNHLEPAIRIKRPGKLKQGVLLQLENVRPHSAQVTLETLHGLGFEILPYPPYSPDLAPSDYHMFGPLKEALRGHRFTSDAEVQHAVQEWLSQLPESFFEDGIKKLVTRWNTCVAKQGDYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAU7</accession>
    <name>A0A151MAU7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0003378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006286">
        <property type="protein sequence ID" value="KYO21634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAU7"/>
    <dbReference type="STRING" id="8496.A0A151MAU7"/>
    <dbReference type="KEGG" id="amj:102562514"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07871">
        <property type="entry name" value="STKc_PCTAIRE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000061">
        <property type="entry name" value="Putative cyclin-dependent kinase 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF52">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="140"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO21634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="470" mass="54042" checksum="F30EF03BF174AD9F" modified="2016-06-08" version="1">MNKMKNFKRRFSLSVPRTETIEESLTEFTEQFNQLNNRKNEDIAHGHLQLGRDFQADPTSISLSEVEGQSPTTVRYRNNNQRRFSMEDVSKRLSLPVDIRLPPEFLQKLQMHSPEFPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDIIHTERSLTLVFEYLDNDLKQYLDNCGNLMSTHNVKIFMFQLLRGLSYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMVTGRPMFPGSTVKEELHLIFRLLGTPTEDSWPGITSNEEFKAYSFTQYLAQPLINHAPRLDTEGIDLLTNLLLYEAKSRISAEAALRHPYFKSLGERVHLLPDTASIFTLKEIQLQKDPGYRGSVFQQSGRGKNRRQSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDF2</accession>
    <name>A0A151MDF2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NXPE family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NXPE3</name>
        <name evidence="3" type="ORF">Y1Q_0003088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDF2"/>
    <dbReference type="eggNOG" id="ENOG502QUD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF9">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585039" evidence="1">
        <location>
            <begin position="18"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="2">
        <location>
            <begin position="226"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO22541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="454" mass="51893" checksum="B870A6DED8503A34" modified="2016-06-08" version="1">MMLAVLAVVVLIHNVHQLEHLDHSTVSGLNWITEPGDQQSSSRTTKIASKTYCGYEHQILSKRERAEEESLLAAIQWPKPPEDKIPFVRSTDPAHSDFVILNHHARFKGRSKCLCHWSTLAKGSKSFNAYGKKSQTEFTLKVYLDLEGIRKQLCAIISHAKGGYQKGLLTAAENLFFQNDVNIKMPVFSSGPDSVTVKPLRFTESGNLERQGPDVFPSGYYYEDQWRPRTHWIHHFNNSVDVTKCLQGKVIYLFGDSTIRQWFEYLTAFVPDLVEFNLGSPKNVGPFMSVDLKHSILLNFRCHGPPIRFTTVFTSELRYIANELNGIVGGRNTVIAITIWSHFSTFPLEVYIRRLRNIRRSIVRLLDRSPKTVVVIRTANVQELGPEVSLFNSDWYSFQLDTIMRKMFSGIAVFFVDAWEMSLAHYLPHNLHPEDVIVKNQVDAFLSFVCPLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDQ1</accession>
    <name>A0A151MDQ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDQ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="8959" checksum="14F38097824E6B63" modified="2016-06-08" version="1">MLLSFWTSSIEVQQISSLDQIPSGIFLQFVKGTPAETLKPGIFKRDLKNPPLKASCLWQGRAHRENIVADQRACLHLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDY5</accession>
    <name>A0A151MDY5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0003237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDY5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585057" evidence="2">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO22738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="184" mass="20421" checksum="7E070ADF5B31A066" modified="2016-06-08" version="1">MVLNGALVAVAIRVPLISSLSRTLVPTQECPTPKQREGLASLALEKVNADSRCYHHFNNRVKWDNLHAQFFGGRVCKQVKPGGSLQSGDEAGSLDSQKRKLWGQEGDNCWSKQNRWSYILSMTLSLLFPGDQELFGGEGSQNIVLTTSPSFLCQVVNINSSTVFLWRFGVLQVYIGMLAFGIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEF3</accession>
    <name>A0A151MEF3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL22m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRPL22</name>
        <name evidence="11" type="ORF">Y1Q_0010928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006228">
        <property type="protein sequence ID" value="KYO22883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014465503.2">
        <property type="nucleotide sequence ID" value="XM_014610017.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEF3"/>
    <dbReference type="STRING" id="8496.A0A151MEF3"/>
    <dbReference type="GeneID" id="106737435"/>
    <dbReference type="KEGG" id="amj:106737435"/>
    <dbReference type="CTD" id="29093"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585087" description="Large ribosomal subunit protein uL22m" evidence="10">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO22883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="217" mass="24980" checksum="CC967223FB2D5B36" modified="2016-06-08" version="1">MRGQSEAATMAAAMAGLAWARRMLLGAWPERFLASVNIFPLSNMHTRSSQEVIGKWEKKNRVVYPPQLPGEPRRPAVIYHCRREIKYSKDKMWYLATLIKGMSIDQALAQLEFNDKKGAKVIKEVLLEAQELAVRKYNVEFKSNLYIAKSLTGKGHYMKKIRYHGRGRYGIMEKVRCHYFVKLVEGPPPPPEPPMTGFDQAKEYVQQLRNRTIINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEN5</accession>
    <name>A0A151MEN5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testis-expressed sequence 264 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TEX264</name>
        <name evidence="2" type="ORF">Y1Q_0005475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO22977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEN5"/>
    <dbReference type="STRING" id="8496.A0A151MEN5"/>
    <dbReference type="eggNOG" id="ENOG502S3D1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949:SF3">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="276" mass="30432" checksum="6A92EBEA2301ED2C" modified="2016-06-08" version="1">MVYSGLFTEVVVSAGTPPIRSITLAYKFRVGPYGESGQLFTESCSISPKLCSISVYYDNPITVLPEKCRYAVGRILTEAPSHVVMATFPFTTPLSIHLAVNRVHPALDTYIKERKLCAYPRLEIYKGDQIHFLCPLARQWDFYVPEMKEIERKSRAAVAEAEDAQTDITGADTLSETSSISLEATTDSRETSVATSILSPFTAGHGRDETDNRSEHSYSESGASGSSFEELDLEVSGDGDSSAALPSELSYTEDQESMKTKWTKEPIALEKERGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MH96</accession>
    <name>A0A151MH96_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LAMP5</name>
        <name evidence="23" type="ORF">Y1Q_0002371</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Cell projection</location>
            <location evidence="18">Growth cone membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasmic vesicle</location>
            <location evidence="16">Secretory vesicle</location>
            <location evidence="16">Synaptic vesicle membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MH96"/>
    <dbReference type="STRING" id="8496.A0A151MH96"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:early endosome membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.110:FF:000002">
        <property type="entry name" value="lysosome-associated membrane glycoprotein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="22">
        <location>
            <begin position="70"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO23760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="307" mass="34434" checksum="6C28EBF0B4348A98" modified="2016-06-08" version="1">MAGQSVNIAQGIATVCESGCRLRQLQRKGDKSRRARTSRQDHLNPLGPEAAARVVAEQEVENLSGLSPNPEKDIFAVKENGKACLVAEFAAKFLVPYYVRDANYVDVITEQADIPLSRGAEIKGKCGTNESELELSWLEKAYTLRLSFIKEGHNTSRGQEVLWKMNKVQFVYDTSEKTYFKEAVTPGKHTANSHQLSALVTPAGKSYVCQAQQTIHLYLSDHQKSIDFLLSEVQIQPFDITNDFAFSEAHKCPVDQREQLEETLPLILGLILGLIIVITLCVYHIHHKLTANQVQLPRDRSQYKHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MI89</accession>
    <name>A0A151MI89_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Bactericidal permeability-increasing protein</fullName>
            <shortName evidence="13">BPI</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0020301</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13">Monomer. Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006102">
        <property type="protein sequence ID" value="KYO24193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MI89"/>
    <dbReference type="STRING" id="8496.A0A151MI89"/>
    <dbReference type="eggNOG" id="KOG4160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031663">
        <property type="term" value="P:lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00025">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00026">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000001">
        <property type="entry name" value="Phospholipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000001">
        <property type="entry name" value="phospholipid transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030675">
        <property type="entry name" value="BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF84">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002417">
        <property type="entry name" value="Lipid_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="5 13" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="9 12 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0391">Immunity</keyword>
    <keyword evidence="6 13" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585133" description="Bactericidal permeability-increasing protein" evidence="14">
        <location>
            <begin position="23"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="15">
        <location>
            <begin position="30"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="16">
        <location>
            <begin position="263"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR002417-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO24193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="472" mass="50728" checksum="5C0BD28AA507C5A9" modified="2016-06-08" version="1">MAVQSLAPAALLLAVSITLARATKPGIVARITGPGLDYALQKGISALEKKLAEMKLPDISGSQETPVGDVYYEFSRLNLRSFRLPSSQITPLPDVGVQVSVSNAFAQLTGNWRWKRGLFGDDGQFNLKVTGLSISVGLQLGRDASGKPTVTASGCTTCISDVDVDAGWIYKLIIKIIKSHIKALMQSQVCREVRSFVSTQLQPYLHALPVTAAIDTVAGVDYSLVAFPVATAQYVDVSLKGEIFSRAHRAPAPFSPPALAFPPEHGRMVYLGVSSYVFNTASFVYQAAGCLVFSITDDVFPKEGFFHLNTSTFYHFVPQLKQRYPDRLMKLQLTTPSAPFLTIAPGGLELALVADVQAYAILPNASLTPLFLLHLTSNVSASVTVSSARICGALASGGLELSLKHSDIGPFPVLGLQQFMNFLASNILLPLVNGKLEKGFPLPLPAHVQLSSCVLQPHQDFLLLGADVRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK59</accession>
    <name>A0A151MK59_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK59"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="151" mass="17180" checksum="FBAFE79F19E2EEBB" modified="2016-06-08" version="1">MKMLNKRRTKESTCIALEKVYRLNLNLHPHENGTQLCGQNKRKDLCWPSAKQALLSQHFLPNSEEFRTVFSGVPYTLLFVATLSLEDFGGSCSKDFERTSASLSSLNSWRSHNEQLQLIQKHNMSTLTLTLHDCLTMAYPSSLKTSQQVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKF4</accession>
    <name>A0A151MKF4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0023845</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO25004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKF4"/>
    <dbReference type="STRING" id="8496.A0A151MKF4"/>
    <dbReference type="eggNOG" id="KOG4194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917255at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05763">
        <property type="entry name" value="IgI_LRIG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000161">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000040">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000150">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000224">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000023">
        <property type="entry name" value="Leucine rich repeats and immunoglobulin like domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF24">
        <property type="entry name" value="LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="429"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="533"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="627"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="880"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="885"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="924"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1015"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO25004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113764" checksum="A38724902C7629A5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKS3</accession>
    <name>A0A151MKS3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (34-2'-O)-methyltransferase regulator WDR6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">WDR6</name>
        <name evidence="12" type="ORF">Y1Q_0023887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs. Required for the correct positioning of the substrate tRNA for methylation. Required to suppress amino acid starvation-induced autophagy. Enhances the STK11/LKB1-induced cell growth suppression activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FTSJ1; the interaction is direct, and required for 2'-O-methylation of position 34 in substrate tRNAs. Interacts with IRS4. Interacts with STK11/LKB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO25059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKS3"/>
    <dbReference type="STRING" id="8496.A0A151MKS3"/>
    <dbReference type="eggNOG" id="KOG0974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151MKS3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO25059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="768" mass="81197" checksum="46AFF93DFF80DD08" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLN7</accession>
    <name>A0A151MLN7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">LSM4</name>
        <name evidence="15" type="ORF">Y1Q_0020786</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005833">
        <property type="protein sequence ID" value="KYO25349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLN7"/>
    <dbReference type="STRING" id="8496.A0A151MLN7"/>
    <dbReference type="eggNOG" id="KOG3293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO25349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="170" mass="18507" checksum="94D514CAF8C4CED5" modified="2016-06-08" version="1">MNNSGLTSPARPEDAVGAAPALVSSPYSRDAIDLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVSKGRGRGGLQQQKQQKGRGAGGTGRGVFGGRGRGIPGSGRGQQEKKPGRQSAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMA2</accession>
    <name>A0A151MMA2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mannan-binding lectin serine protease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MASP1</name>
        <name evidence="7" type="ORF">Y1Q_0013751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005724">
        <property type="protein sequence ID" value="KYO25583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMA2"/>
    <dbReference type="STRING" id="8496.A0A151MMA2"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001867">
        <property type="term" value="P:complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000016">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000112">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000050">
        <property type="entry name" value="mannan-binding lectin serine protease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF13">
        <property type="entry name" value="MANNAN-BINDING LECTIN SERINE PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO25583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="375" mass="41510" checksum="78807D5B5B457197" modified="2016-06-08" version="1">MDVGGDMADCRAPAELEHGFITFASRSNLTTYRSAIRYSCQRPYYRLAPNVTGIYTCDENGIWRSEELGTKLPSCRPVCGRPVRSLPGIIKRIIGGRNAEPGSFPWQALIVVEDTSRVPNDKWFGSGALLSDSWVLTAAHVLRSQRRDNTVIPVSKEHVTVYLGLHDVRRKMAAVNRTVEKIVLHAGFDIQNYNHDIALVKLKERVVMGPYVMPVCLPQFEHELEGPHPNTLGLVAGWGISNPNITVDEIISSGMRTLSDILQYVKLPVVPHAECKASYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIQDPGTQRWVAQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVEENVGASGRWTLPDPQLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMM1</accession>
    <name>A0A151MMM1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Interferon lambda receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IFNLR1</name>
        <name evidence="4" type="ORF">Y1Q_0023589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMM1"/>
    <dbReference type="STRING" id="8496.A0A151MMM1"/>
    <dbReference type="eggNOG" id="ENOG502S4B0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF55">
        <property type="entry name" value="INTERFERON LAMBDA RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01108">
        <property type="entry name" value="Tissue_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585280" evidence="2">
        <location>
            <begin position="21"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO25772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="570" mass="64371" checksum="B1EC55C00B38467D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPX4</accession>
    <name>A0A151MPX4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Selenide, water dikinase 2</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Selenium donor protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Selenophosphate synthase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SEPHS1</name>
        <name evidence="24" type="ORF">Y1Q_0016242</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogenselenide + ATP + H2O = selenophosphate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03005463">
        <property type="protein sequence ID" value="KYO26587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPX4"/>
    <dbReference type="STRING" id="8496.A0A151MPX4"/>
    <dbReference type="eggNOG" id="KOG3939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000003">
        <property type="entry name" value="Selenide, water dikinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000018">
        <property type="entry name" value="selenide, water dikinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="SELENIDE, WATER DIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256:SF1">
        <property type="entry name" value="SELENIDE, WATER DIKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0711">Selenium</keyword>
    <keyword evidence="14" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585342" description="Selenide, water dikinase 2" evidence="21">
        <location>
            <begin position="17"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like N-terminal" evidence="22">
        <location>
            <begin position="37"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="23">
        <location>
            <begin position="161"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO26587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="354" mass="37920" checksum="BFC058431F9056F0" modified="2016-06-08" version="1">METLLRLLAGLGGARAAGEGPVSEPGSSPPALGIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVSQKMTDEEREKIMPLIIKGFRDAAEDGGTSVTGGQTVMNPWIIVGGVATVVCQPNEFIMPDNAVPGDVLVLTKPLGTQVAVTAHQWLDNPERWNKIKLVVSKEDVELAYQEAMFSMAMLNRTAASLMHTFNAHAATDITGFGILGHAQNLARQQRHEVSFVIHNLPIIAKMAAVSKACGNRSGLLQGTSPETSGGLLICLPREQAARFCAEIKSPKHGEGHQAWIIGIVEKGNQTARIIDKPRIIEGPAKLSAAQGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQB3</accession>
    <name>A0A151MQB3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transmembrane protein 106B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TMEM106B</name>
        <name evidence="20" type="ORF">Y1Q_0019192</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Late endosome membrane</location>
            <topology evidence="13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Lysosome membrane</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQB3"/>
    <dbReference type="STRING" id="8496.A0A151MQB3"/>
    <dbReference type="eggNOG" id="ENOG502QQRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009790">
        <property type="entry name" value="TMEM106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048509">
        <property type="entry name" value="TMEM106_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048511">
        <property type="entry name" value="TMEM106_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07092">
        <property type="entry name" value="TMEM106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21002">
        <property type="entry name" value="TMEM106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 17 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 N-terminal" evidence="19">
        <location>
            <begin position="71"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 C-terminal" evidence="18">
        <location>
            <begin position="188"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO26724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="344" mass="37736" checksum="166D9C81F85A5BB7" modified="2016-06-08" version="1">MAAARATRNQSLACQIHALTASQALRTQIAAAAALEHPQDPSGAGHGRESPRPRALCPAPPSVCGGGPGMGKSFSHVPLHTYKEDGSDGGTGSENVRNGLVHSESHAEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVTASVIVCLLLSGLAVFFLFPRSIDVEYVGVKSVYVTYEPSRRIIYLNITNALNITNNNYYSVEVANITAQVQFSKTVIGKARLNNITNIGPLDMKQIDYMVPTVIQDEMSYMYDFCTLISIKVHNIVVMMQVTVTTSYFGHSEQISQERYQYVDCGGNTTYQLGQSEYLNVLQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTC0</accession>
    <name>A0A151MTC0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIM domain-binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LDB3-2</name>
        <name evidence="6" type="ORF">Y1Q_0005301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTC0"/>
    <dbReference type="STRING" id="8496.A0A151MTC0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000014">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000020">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF9">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO27752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="185" mass="20912" checksum="1E0875AEA9533214" modified="2016-06-08" version="1">MAPAVARGTIQRAERFPASSRTPLCGHCNSIIRGPFLVAMGRSWHPEEFNCAYCKTSLADVCFVEEQNSVYCERCYEQFFAPTCARCHTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYVALFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHEELEVVDFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTP4</accession>
    <name>A0A151MTP4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005066">
        <property type="protein sequence ID" value="KYO27873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTP4"/>
    <dbReference type="eggNOG" id="KOG1323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF305">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="428" mass="48104" checksum="43CC05BE6CF312B2" modified="2016-06-08" version="1">MLRIWGQQPGCWAAGLPAPREVINSGKSQHNEDQACCEVVFVQRRPGQRRNPAAGESEWGRKSLYFHYWGLFDGHAGSGAAIMASKLLHRHVCEQLRDLVDILQDPAPAPICLQSDARVPAEASRAALAEEDAEPLNDALPRFHLEKAVSHESLVIGAIENAFKQMDDQIERERATRHVSGGCCALVAVYLLGKFYVANAGDSRAIIIRNGEIIPMSREFTPETERQRLQFLGFLRPELLGNEFTHLEFPRRIQHKELGKKMLYRDQSMNGWAYKKIEEDDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVYSSNIHIKPFLCCYPEVRVYDLTQYEHCPDDVLVLGTDGLWDVTNDKEVAEVVMDVLMGYEPNDPCRYTMVAQELVVRSRGVLKERGWRLANDKLGSGDDISVFVIPLGGPGNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV21</accession>
    <name>A0A151MV21_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 27">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="27">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="primary">INO80</name>
        <name evidence="34" type="ORF">Y1Q_0015974</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="27">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="25">ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24 36">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="27">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="26">Component of the chromatin remodeling INO80 complex; three different complex modules assemble on different domains of INO80. Interacts with DDB1. Interacts with transcriptional repressor protein YY1; the interaction recruits the INO80 complex to YY1 target genes. Interacts with YY1AP1. Interacts with tubulin alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 27">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="27">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="27"/>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MV21"/>
    <dbReference type="eggNOG" id="KOG0388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051054">
        <property type="term" value="P:positive regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033044">
        <property type="term" value="P:regulation of chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000747">
        <property type="entry name" value="DNA helicase INO80 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003788">
        <property type="entry name" value="INO80 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="19" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="15 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="23" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="28" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12 27" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="20 27" id="KW-0234">DNA repair</keyword>
    <keyword evidence="17 27" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="34" id="KW-0347">Helicase</keyword>
    <keyword evidence="14 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="30" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="30">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585476" description="Chromatin-remodeling ATPase INO80" evidence="30">
        <location>
            <begin position="24"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="domain" description="DBINO" evidence="33">
        <location>
            <begin position="261"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="31">
        <location>
            <begin position="511"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="32">
        <location>
            <begin position="1088"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1262"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1371"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1486"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="28">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="29">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="29">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="1262"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="1286"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="1373"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="1490"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="1503"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00053113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00064711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="KYO28370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1539" mass="175016" checksum="EF80907421E219A2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVA7</accession>
    <name>A0A151MVA7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase-associated RTF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RTF1</name>
        <name evidence="2" type="ORF">Y1Q_0015980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVA7"/>
    <dbReference type="STRING" id="8496.A0A151MVA7"/>
    <dbReference type="eggNOG" id="KOG2402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="233" mass="25298" checksum="B5E9BD467DB35E48" modified="2016-06-08" version="1">MTQHDAGMTSPPQTRSPEGQLQRGSARAASPATPHLPRGLQLKGSELLSLAKRKRSDSEEKEPPVSKPTASSDSETSDSDDEWTVGGSKNKKKGKAGKAEKKAAMKKQANRAASSGSSDKDSSAESSAPEEGEVSDSESNSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRVYMVMSTSCTSVSSAAESRCAGLQRREEDEHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MW75</accession>
    <name>A0A151MW75_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin, alpha cardiac muscle 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0004414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004772">
        <property type="protein sequence ID" value="KYO28752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MW75"/>
    <dbReference type="SMR" id="A0A151MW75"/>
    <dbReference type="STRING" id="8496.A0A151MW75"/>
    <dbReference type="KEGG" id="amj:106736711"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MW75"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0558">Oxidation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO28752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42019" checksum="E5C10FA19730CAD2" modified="2016-06-08" version="1">MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWB4</accession>
    <name>A0A151MWB4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pleckstrin-like proteiny domain-containing family A member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PLEKHA2</name>
        <name evidence="14" type="ORF">Y1Q_0018098</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004780">
        <property type="protein sequence ID" value="KYO28738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWB4"/>
    <dbReference type="STRING" id="8496.A0A151MWB4"/>
    <dbReference type="eggNOG" id="ENOG502QV0M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13271">
        <property type="entry name" value="PH2_TAPP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000049">
        <property type="entry name" value="pleckstrin homology domain-containing family A member 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000042">
        <property type="entry name" value="pleckstrin homology domain-containing family A member 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="81"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="254"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="371"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO28738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="482" mass="53500" checksum="2370FBFAF19F5D82" modified="2016-06-08" version="1">MESESGAKRALDNAMVEVQEVRARVIGVECGVAEELDKEHCLIQPAVGRGWAGLGKHSTFPAKDPAAPKGDENETCGKFLRRYFILDTQANCLLWYMDNPQNLAVGSGAVGSLPLTYISKVSIATLKQKPKTPFCFVINALSQRYFLQASDQKDLQDWVEALNRASKITVPKGGNSPPATEITKPPIVPQAQDKKPQVAYKTEIIGGVVVHTPISINQNGGDGAEGSDPAGHHLLRRSQSYIPPSGTKPSTGPPSLKSGYCVKQGNVRKSWKRRYFVLDEFSISYFKYEQDKEPVRSILLKDVLKTHECLVKSGDLLMRDNLFEIITSNRTFYIQADSPEDMHSWIKAITGALQALKIRPRETSFVRSISMNRQGGSNHSSSSTASLSQLRQPGEERRALCKGPSTSSWQPWTPVPQPEGKQPTIEEAPGQLRDSVFVPAFTERDMSTRQGKRVRHKSEPQHLKEKPFTFNLDDENIRTSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX13</accession>
    <name>A0A151MX13_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARL15</name>
        <name evidence="7" type="ORF">Y1Q_0009899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX13"/>
    <dbReference type="STRING" id="8496.A0A151MX13"/>
    <dbReference type="eggNOG" id="KOG0071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000934">
        <property type="entry name" value="ADP-ribosylation factor-like 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042292">
        <property type="entry name" value="ARL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO29101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="215" mass="24144" checksum="E3308BCF35ECC3E9" modified="2016-06-08" version="1">MSLHFFQRMSECIQLSFAVCRIGIYTCFRGLCCKGPPPPRPEYDLVCIGLTGSGKTSLLSRLCSESPENVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEIKKYFELEPLARGKRWILKPCSLDDMEAFNFDVVTSFFSVNCFPAAHFEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXS0</accession>
    <name>A0A151MXS0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Collagen alpha-1(XIV) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0017909</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MXS0"/>
    <dbReference type="Proteomes" id="UP000050525">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005614">
        <property type="term" value="C:interstitial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd01482">
        <property type="entry name" value="vWA_collagen_alphaI-XII-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000403">
        <property type="entry name" value="collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000444">
        <property type="entry name" value="Collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000514">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000546">
        <property type="entry name" value="Collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000615">
        <property type="entry name" value="collagen alpha-1(XIV) chain isoform X2"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000656">
        <property type="entry name" value="collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.120.200:FF:000008">
        <property type="entry name" value="Collagen type XII alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000234">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF15">
        <property type="entry name" value="COLLAGEN ALPHA-1(XIV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585560" description="Collagen alpha-1(XIV) chain" evidence="15">
        <location>
            <begin position="29"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="32"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="16">
        <location>
            <begin position="167"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="366"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="456"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="548"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="637"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="752"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="843"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="16">
        <location>
            <begin position="1050"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1473"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1664"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1591"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1619"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1671"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1707"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1747"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1764"/>
            <end position="1775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO29255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1864" mass="200810" checksum="738E6F2277AAB428" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MY18</accession>
    <name>A0A151MY18_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meckelin isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM67</name>
        <name evidence="3" type="ORF">Y1Q_0018051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KYO29446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019495741.2"/>
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    <dbReference type="STRING" id="8496.A0A151MY18"/>
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    <dbReference type="KEGG" id="amj:102563102"/>
    <dbReference type="CTD" id="91147"/>
    <dbReference type="eggNOG" id="KOG4611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419138at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019170">
        <property type="entry name" value="Meckelin"/>
    </dbReference>
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        <property type="entry name" value="MECKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21274:SF2">
        <property type="entry name" value="MECKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09773">
        <property type="entry name" value="Meckelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585572" evidence="2">
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            <begin position="26"/>
            <end position="984"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="578"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO29446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="984" mass="110125" checksum="E4E5719AF031BE31" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZ82</accession>
    <name>A0A151MZ82_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sushi domain-containing protein 3 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SUSD3-1</name>
        <name evidence="5" type="ORF">Y1Q_0023170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZ82"/>
    <dbReference type="STRING" id="8496.A0A151MZ82"/>
    <dbReference type="eggNOG" id="ENOG502RY7E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053067">
        <property type="entry name" value="SUSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46879">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46879:SF1">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="4">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO29817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="250" mass="28289" checksum="07E5A206E615D62E" modified="2016-06-08" version="1">MREDAGRAPRNYTGQCSQIFPPQLGTLQIIHGNGTTVGTVITFQCSAEHQLEGQGVVTCIWKGNSAQWTAGVPSCKPISKYETFGFKVAVIASIVSCAIILLMSMAFLTCCLIKCVKKSERRRTERDMQLWYQLRTEELENMQAAYFGFKGRNNNNNKKLRKKTVFDDGANMAYDNQGFCRFQEEWTRDITVSAHYRENDHQPKFNKSAPTKILVTGHKTTVPTVKTIHIVEVYGHDKEIYKNSNSHLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZT9</accession>
    <name>A0A151MZT9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger MYND domain-containing protein 12 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZMYND12-1</name>
        <name evidence="6" type="ORF">Y1Q_0000187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004374">
        <property type="protein sequence ID" value="KYO30032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZT9"/>
    <dbReference type="GeneID" id="102569502"/>
    <dbReference type="KEGG" id="amj:102569502"/>
    <dbReference type="CTD" id="84217"/>
    <dbReference type="OrthoDB" id="3174329at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MZT9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO30032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="369" mass="41178" checksum="37CDD1E7E5CB2DB1" modified="2016-06-08" version="1">MQAQELVPLALPRGRGRHCELCGAAAQLRCGACGVTYYCDADHQKADWDSIHEKICPLLTPVRTSVPFFSSEKERKHGAEQLLRRQKYIADLTYEVAQKFLYEGKHEEAIPAALHSLRFSISIYGSNSVKLVPAYLILAEASTGLGHLTQADEYLSQAQWIVLKTPDCTNAIQSKLHRNLGLVYAAKGDFEQSLYHLANDIYFASCAFGTHDTSTSGGYFHMANVFFRQNKMDIADSLYSEATDIWHAHFSRLIQIQSQTLKSATEIDILAGDVEASEEPLTGEAQQAEASQILNAILDIREQAPKQKPDKMAIVLHALAMLHYFTMDLPKAHELGVKASLITQQLQNQDLLEDIRCLLKLIKSKNVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2F2</accession>
    <name>A0A151N2F2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MAP2K6</name>
        <name evidence="17" type="ORF">Y1Q_0016339</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2F2"/>
    <dbReference type="STRING" id="8496.A0A151N2F2"/>
    <dbReference type="eggNOG" id="KOG0984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06617">
        <property type="entry name" value="PKc_MKK3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000126">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000158">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF12">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="67"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO30940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="348" mass="39211" checksum="22E6A1CCC6255332" modified="2016-06-08" version="1">MPTEKLAGNRERDGCLQKHGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGEKNFEVKADDLEPISELGRGAYGVVEKMRHMPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKHVIDKGLTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADRFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKETDVASFVKLILGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2Z1</accession>
    <name>A0A151N2Z1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2Z1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="9593" checksum="C7BA03D38FAAF011" modified="2016-06-08" version="1">MLMRSHWRPGSDTQAALRASASSPCILKSSSVLQQVRGYAEVRRTRLHRAEPEHSCLVGNFGRGGTLHSLRIALFPSSLPLPLSPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4B7</accession>
    <name>A0A151N4B7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch-like protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">KLHL22</name>
        <name evidence="23" type="ORF">Y1Q_0022746</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4B7"/>
    <dbReference type="STRING" id="8496.A0A151N4B7"/>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005827">
        <property type="term" value="C:polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18461">
        <property type="entry name" value="BACK_KLHL22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18251">
        <property type="entry name" value="BTB_POZ_KLHL22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11759">
        <property type="entry name" value="SH3_CRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11758">
        <property type="entry name" value="SH3_CRK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000065">
        <property type="entry name" value="adapter molecule crk isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000163">
        <property type="entry name" value="crk-like protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000018">
        <property type="entry name" value="Kelch-like family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000040">
        <property type="entry name" value="Kelch-like family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000083">
        <property type="entry name" value="Kelch-like family member 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035458">
        <property type="entry name" value="CRK_SH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035457">
        <property type="entry name" value="CRK_SH3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030575">
        <property type="entry name" value="KLHL22_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF5">
        <property type="entry name" value="KELCH-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 19" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="22">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="613"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="725"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="674"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO31632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="793" mass="89832" checksum="1C090A1FDA43B9A9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5Z9</accession>
    <name>A0A151N5Z9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003989">
        <property type="protein sequence ID" value="KYO32264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5Z9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="133" mass="13900" checksum="D8606347661D2F09" modified="2016-06-08" version="1">MGSPHPVRRAGPVDGEPGRLQLEGTRAVPSLAEPQLGDSTEVPATPEEEAAALAARRRRSLRSSSAPSPAPAPAPTTAPVLRRSQRRRAEATPPKPPQRHRTQGSSGLKAPGDAGSKARAPEDAEREASQSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6Z6</accession>
    <name>A0A151N6Z6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tubulin alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0020322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003955">
        <property type="protein sequence ID" value="KYO32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6Z6"/>
    <dbReference type="STRING" id="8496.A0A151N6Z6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000024">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="127" mass="14115" checksum="7880064463B78654" modified="2016-06-08" version="1">MRECISIHVGQAGVQIGNACWELYCLEHGIQPNGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7M7</accession>
    <name>A0A151N7M7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Four and a half LIM domains protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FHL1</name>
        <name evidence="17" type="ORF">Y1Q_0009362</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019348342.1">
        <property type="nucleotide sequence ID" value="XM_019492797.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7M7"/>
    <dbReference type="STRING" id="8496.A0A151N7M7"/>
    <dbReference type="GeneID" id="106737767"/>
    <dbReference type="KEGG" id="amj:106737767"/>
    <dbReference type="CTD" id="2273"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09424">
        <property type="entry name" value="LIM2_FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000013">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000052">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000050">
        <property type="entry name" value="Four and a half LIM domains protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000072">
        <property type="entry name" value="Four and a half LIM domains protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042997">
        <property type="entry name" value="Fhl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056807">
        <property type="entry name" value="LIM_FHL1/2/3/5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47029">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47029:SF2">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25076">
        <property type="entry name" value="LIM_FHL2-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 15" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO32761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="298" mass="34246" checksum="36A876047FB30070" modified="2016-06-08" version="1">MAFHRHTGGPSSYTVGTMSDRFDCHYCRDSLHGKKYVQKDGRHCCVKCFEKFCANTCTECRKPIGADSKELHFKNRYWHDSCFHCTKCYASLVNEPFMLRENNKVWCSNCTAKDEAPRCKGCYKPIIAGDQNVEYKKSVWHKDCFTCYQCKTVIGTGSFFPKGDDIYCVSCHEHKFAKTCAKCKNPITSGGITYQEQPWHSECFVCTSCKKPIGGRRFTAVENDFYCVDCYKECVAKKCAGCQSPITGFGRGSSVVNYEDQSWHDYCFKCKKCSRPLANRRFVCHNQQIYCPECPHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8D5</accession>
    <name>A0A151N8D5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional enhancer factor TEF-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TEAD3</name>
        <name evidence="7" type="ORF">Y1Q_0014890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8D5"/>
    <dbReference type="STRING" id="8496.A0A151N8D5"/>
    <dbReference type="eggNOG" id="KOG3841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151N8D5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000001">
        <property type="entry name" value="Transcriptional enhancer factor TEF-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YAP binding" evidence="6">
        <location>
            <begin position="111"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO33084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="322" mass="36126" checksum="A379FEBF64AD991C" modified="2016-06-08" version="1">MNLDQVSKDKALQSMASMSSAQIVSASVLQNKLSPPPPLPQAVFSAAPRFWSGPIPGQPGPSQDIKPFAQPAYPIQSPMPPSLASYEPLAPLPPTASAVPVWQDRTIASAKLRLLEYSAFMEVPRDAETYSKHLFVHIGQTNPSYSDPLLEAVDIRQIYDKFPEKKGGLKELYERGPQNSFFLVKFWADLNSTIQDGPGTFYGVSSQYSSAENMTITVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAFVFEVSTSEHGAQHHVYKLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8T4</accession>
    <name>A0A151N8T4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase 1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PPP1R12B-2</name>
        <name evidence="8" type="ORF">Y1Q_0015009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8T4"/>
    <dbReference type="STRING" id="8496.A0A151N8T4"/>
    <dbReference type="eggNOG" id="KOG0505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21944">
        <property type="entry name" value="IPD_MYPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000004">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000898">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017401">
        <property type="entry name" value="MYPT1/MYPT2/Mbs85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF18">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038141">
        <property type="entry name" value="PP1_12ABC_vert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="794"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="881" mass="98076" checksum="AAC09490A7CF01C3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAX9</accession>
    <name>A0A151NAX9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neprilysin</fullName>
            <ecNumber evidence="5">3.4.24.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Atriopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Enkephalinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Neutral endopeptidase 24.11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Skin fibroblast elastase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">MME</name>
        <name evidence="33" type="ORF">Y1Q_0024594</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.</text>
            <dbReference type="EC" id="3.4.24.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>neurotensin + H2O = neurotensin(1-10) + L-tyrosyl-L-isoleucyl-L-leucine</text>
            <dbReference type="Rhea" id="RHEA:71479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:147362"/>
            <dbReference type="ChEBI" id="CHEBI:190705"/>
            <dbReference type="ChEBI" id="CHEBI:190707"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:71480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>neurotensin + H2O = neurotensin(1-11) + L-isoleucyl-L-leucine</text>
            <dbReference type="Rhea" id="RHEA:71475"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:147362"/>
            <dbReference type="ChEBI" id="CHEBI:190704"/>
            <dbReference type="ChEBI" id="CHEBI:190706"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:71476"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>substance P + H2O = substance P(1-7) + L-Phe-Gly-L-Leu-L-Met-NH2</text>
            <dbReference type="Rhea" id="RHEA:71467"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:190692"/>
            <dbReference type="ChEBI" id="CHEBI:190695"/>
            <dbReference type="ChEBI" id="CHEBI:190698"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:71468"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>substance P + H2O = substance P(1-9) + L-Leu-L-Met-NH2</text>
            <dbReference type="Rhea" id="RHEA:71459"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:190692"/>
            <dbReference type="ChEBI" id="CHEBI:190693"/>
            <dbReference type="ChEBI" id="CHEBI:190700"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:71460"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.11" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAX9"/>
    <dbReference type="STRING" id="8496.A0A151NAX9"/>
    <dbReference type="GlyCosmos" id="A0A151NAX9">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097242">
        <property type="term" value="P:amyloid-beta clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF114">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="32">
        <location>
            <begin position="123"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="31">
        <location>
            <begin position="587"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00031362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00031486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00032584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="KYO33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="794" mass="90832" checksum="78A26F28849710AC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBS5</accession>
    <name>A0A151NBS5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibromodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FMOD</name>
        <name evidence="14" type="ORF">Y1Q_0023695</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds to type I and type II collagen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003562">
        <property type="protein sequence ID" value="KYO34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBS5"/>
    <dbReference type="STRING" id="8496.A0A151NBS5"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000073">
        <property type="entry name" value="Lumican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF4">
        <property type="entry name" value="FIBROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="287" mass="32961" checksum="D752497C1E4EE725" modified="2016-06-08" version="1">MYCDGRNLRYLPFVPSRMKYVYFQNNQITSIQEAAFDNATNLEWIALHGNQISSEKMGKKIFAKLKNLERLYLNNNNLTKMPGPLPRSLRELHLAYNQISKIPANALEGLENLTALYLSHNYIYEIAASFKGLKSLILVDLSYNHLRKVPDGLPIALEQLYLDYNYINTIPDEYFKVSPKLLYVRLAHNTLTNEGLASNAFNSSSILELDLSYNRFQKIPRVSTQLENLYLQGNQINEFSISSFCTVVDVMNFSRLQVLRLDGNEIQRNAMPPDAPLCLRRANVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ND10</accession>
    <name>A0A151ND10_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Angiopoietin-related protein 4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ANGPTL4-1</name>
        <name evidence="8" type="ORF">Y1Q_0011935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003404">
        <property type="protein sequence ID" value="KYO34499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ND10"/>
    <dbReference type="STRING" id="8496.A0A151ND10"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="7">
        <location>
            <begin position="79"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO34499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="359" mass="41065" checksum="61CDC577AE879AB6" modified="2016-06-08" version="1">MALMDAQNTRIEALLQKTKQQQYKLDKQSLQIKSLQSKVNLLIPFHLKDNKTQSPKWRINLKKSFSHANQSQNASMESAQTQRLPVDCQQLFLEGERSSGLFQIQPPGAQPFKVHCDMTAEGAWTVIQRRVDGSVDFDQLWEAYKNGFGDLNGDFWLGLEKIYSIVQNRRYNLLIELEDWEGEKQLIQFLFSLGEENTAYTLSLLGPVSGELENAVGDFRQLPFSTRDQDHDLKADTNCAKHLSGGWWFSSCGHANLNGKYFRSIPRQRHERKQGIFWKTWKGRLDQSYFLWSTDAGLMSSLSPCTEARKRTSELHLEPIATALRCLECLGAQNALDAPWGKRPILPLQPKSSDWDILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ND46</accession>
    <name>A0A151ND46_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acrosin</fullName>
            <ecNumber evidence="2">3.4.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ACR</name>
        <name evidence="12" type="ORF">Y1Q_0017095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.10"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.10" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03003349">
        <property type="protein sequence ID" value="KYO34713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ND46"/>
    <dbReference type="STRING" id="8496.A0A151ND46"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007340">
        <property type="term" value="P:acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000060">
        <property type="entry name" value="Acrosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF8">
        <property type="entry name" value="ACROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585963" description="Acrosin" evidence="10">
        <location>
            <begin position="30"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="49"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="470"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO34713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="675" mass="72666" checksum="64B539A015013DCF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDI5</accession>
    <name>A0A151NDI5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">APEX2</name>
        <name evidence="14" type="ORF">Y1Q_0006654</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03003292">
        <property type="protein sequence ID" value="KYO34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014464403.1">
        <property type="nucleotide sequence ID" value="XM_014608917.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDI5"/>
    <dbReference type="STRING" id="8496.A0A151NDI5"/>
    <dbReference type="GeneID" id="102563647"/>
    <dbReference type="KEGG" id="amj:102563647"/>
    <dbReference type="CTD" id="27301"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NDI5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF27">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="13">
        <location>
            <begin position="4"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="473" mass="50730" checksum="12EF6EBD9278E081" modified="2016-06-08" version="1">MRLATWNVNGLRAGPGPGPILAALDAHVVCLQETRLTRDQLDDSLTQVEGYTSYFSCCRTRLGYSGVATFCRAEATPEAAEEGLSGLLAGPGAMGSYVDSGSFSPEELAVLDSEGRALVTHHRIRMPWGAETMLTVLNVYCPHAGPRQPLHPVPQHRFLQLLRNRALSLLHHGGHVVIMGDLNIAHRPIDHCQPGDPEAFAANPARCWLDELLSGDGSGGPFVDTFRLRHPGQRQAFSCWRGGTGLGVRAANQGTRLDYILADRVLALGALAGASLLPSVLGSDHCPVLAQLGGAFVPAPHPPALATRRTQLSLHPFLAPRGPPTPLPSPSGARKRLAPTRLPQMGDLRQYFKVKGPSPDALGDCGEKLSRYALGQKQQEPPHDATVQSLKEMEVAQTGLEQNNQEPSQHALGKHGQGIAQHAKGSRGQMTTQHSLGLRDLRRYFKVEGGATGPSQHAVGQHRQAPSQKTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NF36</accession>
    <name>A0A151NF36_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 236 isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF236</name>
        <name evidence="15" type="ORF">Y1Q_0007978</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35394.1"/>
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        <property type="entry name" value="Zinc finger protein 236 variant"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="24"/>
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    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN 236"/>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
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    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
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    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="28"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="41"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
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        <location>
            <begin position="257"/>
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        <location>
            <begin position="289"/>
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    </feature>
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        <location>
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        <location>
            <begin position="567"/>
            <end position="594"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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        </location>
    </feature>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="13">
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    </feature>
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        <location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO35394.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1857" mass="206317" checksum="3FC08CD6803E0551" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NF89</accession>
    <name>A0A151NF89_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ribosyldihydronicotinamide dehydrogenase [quinone]</fullName>
            <ecNumber evidence="15">1.10.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">NRH dehydrogenase [quinone] 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NRH:quinone oxidoreductase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Quinone reductase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NQO2</name>
        <name evidence="22" type="ORF">Y1Q_0008052</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol</text>
            <dbReference type="Rhea" id="RHEA:12364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15927"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:55458"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.10.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.5.1" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NF89"/>
    <dbReference type="STRING" id="8496.A0A151NF89"/>
    <dbReference type="eggNOG" id="ENOG502QWY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001512">
        <property type="term" value="F:dihydronicotinamide riboside quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000030">
        <property type="entry name" value="ribosyldihydronicotinamide dehydrogenase [quinone]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF33">
        <property type="entry name" value="RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Flavodoxin-like fold" evidence="21">
        <location>
            <begin position="7"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO35486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="281" mass="31038" checksum="4F2062682A950B2F" modified="2016-06-08" version="1">MAAPGRKVLIVYAHQEPKSLNGSLKNIAVEELSKQSCSVTVSDLYSMEFEPRATRNDIVGCLHNSEQFNYGAESWEAYRKGCLTTDIVEEQKKVQEADLVIFQFPLYWFSMPAIMKGWMDRVLTQGFAHNFPDCFDAGLLKNKLALLSFTTGGNEEMYSKGGISGDIHYVLWPMQHGILHFCGFKVLAPQICFSPEYETEEKRKEMLTTWAQRLKTIWEEKPINCTPEWYFSRTSPRGEPGPVPGRLLPAARLAETGGGGTAGLASAGLGSPGAGAGTRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFE0</accession>
    <name>A0A151NFE0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuritin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NRN1</name>
        <name evidence="9" type="ORF">Y1Q_0008074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neuritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFE0"/>
    <dbReference type="STRING" id="8496.A0A151NFE0"/>
    <dbReference type="eggNOG" id="ENOG502RZNR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990138">
        <property type="term" value="P:neuron projection extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026144">
        <property type="entry name" value="Neuritin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15902:SF1">
        <property type="entry name" value="NEURITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15902">
        <property type="entry name" value="NEURITIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15056">
        <property type="entry name" value="NRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO35513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="164" mass="18146" checksum="500327CD3392BCE0" modified="2016-06-08" version="1">MKGNSSFTMFSPVYSYDESSWMGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFRGFSNCLLRLGDNMANYPQDLDDKRNLQTICSYWDDFHACTLTALTDCQEGATDLWEKLKRESKNLDFQGSLFELCGGSNGSAPSLLFPALPVLLVSLSAALVTWLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFK1</accession>
    <name>A0A151NFK1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin-20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Y1Q_0008087</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFK1"/>
    <dbReference type="STRING" id="8496.A0A151NFK1"/>
    <dbReference type="KEGG" id="amj:102569797"/>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NFK1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000008">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000009">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000012">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000017">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000014">
        <property type="entry name" value="Cadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF84">
        <property type="entry name" value="CADHERIN-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="86"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="167"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="276"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="391"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="495"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO35530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="800" mass="89530" checksum="AC7B7CB6EE5A81F4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG65</accession>
    <name>A0A151NG65_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="7">2.3.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">F13A1</name>
        <name evidence="11" type="ORF">Y1Q_0008075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG65"/>
    <dbReference type="STRING" id="8496.A0A151NG65"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072378">
        <property type="term" value="P:blood coagulation, fibrin clot formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000171">
        <property type="entry name" value="protein-glutamine gamma-glutamyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF42">
        <property type="entry name" value="COAGULATION FACTOR XIII A CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="10">
        <location>
            <begin position="522"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO35515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="986" mass="111453" checksum="AC8CC142F08E965C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGM3</accession>
    <name>A0A151NGM3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0009284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003035">
        <property type="protein sequence ID" value="KYO35937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGM3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO35937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="157" mass="16825" checksum="9055B5760EAA2D73" modified="2016-06-08" version="1">MPTQARQFHNCLSLQIGELQGCDSGEVQAAQKAARNTADGPGRGEQDAGWETPTAEPGSTSPECRDKGLSRVDASGQALGAVLSQKVEGAERPVAYASRKLNDQERRDTSEDSQDHQEKALPHTHPAPDPNTTGVKVNSSWKETLTQAGQFWSCLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGV0</accession>
    <name>A0A151NGV0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Diacylglycerol kinase</fullName>
            <shortName evidence="20">DAG kinase</shortName>
            <ecNumber evidence="20">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">DGKA</name>
        <name evidence="25" type="ORF">Y1Q_0013090</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43428"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18155"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:78227"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:43429"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40323"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40324"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="19">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="20"/>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGV0"/>
    <dbReference type="STRING" id="8496.A0A151NGV0"/>
    <dbReference type="GeneID" id="102572496"/>
    <dbReference type="KEGG" id="amj:102572496"/>
    <dbReference type="eggNOG" id="KOG1169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20846">
        <property type="entry name" value="C1_DGKgamma_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20892">
        <property type="entry name" value="C1_DGKgamma_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000017">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.110:FF:000009">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.110:FF:000010">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000003">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000013">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000016">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000003">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.110">
        <property type="entry name" value="Diacylglycerol kinase alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047475">
        <property type="entry name" value="C1_DGKgamma_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029477">
        <property type="entry name" value="DAG_kinase_typeI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038199">
        <property type="entry name" value="DGK_typeI_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF36">
        <property type="entry name" value="DIACYLGLYCEROL KINASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14513">
        <property type="entry name" value="DAG_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="356"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="421"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="23">
        <location>
            <begin position="534"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="139"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO36041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="903" mass="101064" checksum="283A975545E99574" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHP2</accession>
    <name>A0A151NHP2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Extracellular serine/threonine protein kinase FAM20C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FAM20C</name>
        <name evidence="18" type="ORF">Y1Q_0024080</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus inner membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHP2"/>
    <dbReference type="STRING" id="8496.A0A151NHP2"/>
    <dbReference type="eggNOG" id="KOG2687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070166">
        <property type="term" value="P:enamel mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10314">
        <property type="entry name" value="FAM20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21438">
        <property type="entry name" value="SUN2_cc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000009">
        <property type="entry name" value="SUN domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040994">
        <property type="entry name" value="Sun_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF25">
        <property type="entry name" value="FAM20 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18580">
        <property type="entry name" value="HTH_SUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="17">
        <location>
            <begin position="1050"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="503"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="777"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1212" mass="136716" checksum="4FA1CC9D72195D3E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIB0</accession>
    <name>A0A151NIB0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RANGAP1</name>
        <name evidence="10" type="ORF">Y1Q_0024036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIB0"/>
    <dbReference type="STRING" id="8496.A0A151NIB0"/>
    <dbReference type="KEGG" id="amj:102572295"/>
    <dbReference type="eggNOG" id="KOG1909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NIB0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000142">
        <property type="entry name" value="Ran GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.200">
        <property type="entry name" value="Ran-GTPase activating protein 1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009109">
        <property type="entry name" value="Ran_GTPase_activating_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036720">
        <property type="entry name" value="RanGAP1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07834">
        <property type="entry name" value="RanGAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69099">
        <property type="entry name" value="Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ran-GTPase activating protein 1 C-terminal" evidence="9">
        <location>
            <begin position="394"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO36255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="568" mass="61519" checksum="B2D9B89950ECCD5D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKB6</accession>
    <name>A0A151NKB6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MAP3K12-binding inhibitory protein 1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MBIP-1</name>
        <name evidence="1" type="ORF">Y1Q_0008945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002792">
        <property type="protein sequence ID" value="KYO37251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKB6"/>
    <dbReference type="STRING" id="8496.A0A151NKB6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="276" mass="31083" checksum="211620A8E6958889" modified="2016-06-08" version="1">MAAVVELSDCPAYACDSELNLGDDVVKIVIDWSKLQSTSALQPTLLFSALQQHILFLQPLLEKLQSSIKEENTGHDETTEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAVFTPYPGFKSHVKVSRVVNTYGPQTRSEGAHGSNKASIPVRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGLSPEYFQSVNFSGKRRKVQPPHQNYSLAELDEKINAIKQALLRKTKEAKSKEVDQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NL52</accession>
    <name>A0A151NL52_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RBM14L</name>
        <name evidence="4" type="ORF">Y1Q_0010416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002706">
        <property type="protein sequence ID" value="KYO37480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NL52"/>
    <dbReference type="KEGG" id="amj:102568930"/>
    <dbReference type="eggNOG" id="ENOG502R6FF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1879688at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO37480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="636" mass="65664" checksum="F19DEE74CAABFE98" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLS4</accession>
    <name>A0A151NLS4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Syntaxin-11 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">STX11-1</name>
        <name evidence="6" type="ORF">Y1Q_0022031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002600">
        <property type="protein sequence ID" value="KYO37743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLS4"/>
    <dbReference type="STRING" id="8496.A0A151NLS4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15878">
        <property type="entry name" value="SNARE_syntaxin11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000015">
        <property type="entry name" value="Syntaxin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042781">
        <property type="entry name" value="Syntaxin11_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF30">
        <property type="entry name" value="SYNTAXIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="267"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO37743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="466" mass="53173" checksum="27D759233A4831B3" modified="2016-06-08" version="1">MEKPSGQQLLAVEEFALFPEVKSQVKTRSCHCLKGALDLSSGAWTPKVLRTTGPIQRSGGKGRMRDRLFELCELARIYNQQFPNDENDISSPTETLLYETDYALASLYKDIQTVRTENNHLKEDIKRLGKQNKRFLTSMRRLSSIKRDTNSIAKDIKARGEGIHRKLQTMRDFTEDAETNFGAVSVVARVSKDHYVDLMHAFQQAMFAYNETEMNQRENCKIRIQRQLEVMGKDVSGNQIEDMIEQGKWDVFSENLLSDVKGARAALNEIETRHKELMKLESRIREVHELFLQVAILVEQQADTFDVIEINVQNVEDYVGEAKVKSRYECARSCMETWVRVSGSSHGDGSQSHPVYSLKKRPKLQVTASSTFSQSHSSALERIPAVENLKIFSFFAGQRIHRISVFSGKGDATLFWLLQVLRHSHWWFANTAMPAPGENRPGHAQRQPVLLHSDGCPTQDRCMTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLY3</accession>
    <name>A0A151NLY3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphoglucomutase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PGM2</name>
        <name evidence="13" type="ORF">Y1Q_0011135</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002590">
        <property type="protein sequence ID" value="KYO37798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLY3"/>
    <dbReference type="STRING" id="8496.A0A151NLY3"/>
    <dbReference type="eggNOG" id="KOG1220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047933">
        <property type="term" value="F:glucose-1,6-bisphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000016">
        <property type="entry name" value="Glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000017">
        <property type="entry name" value="glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000018">
        <property type="entry name" value="Glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF2">
        <property type="entry name" value="GLUCOSE 1,6-BISPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="66"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="239"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="381"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO37798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="681" mass="76627" checksum="96B68AFA1CF2D462" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NND9</accession>
    <name>A0A151NND9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Moesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MSN</name>
        <name evidence="7" type="ORF">Y1Q_0015600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NND9"/>
    <dbReference type="STRING" id="8496.A0A151NND9"/>
    <dbReference type="eggNOG" id="KOG3529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17187">
        <property type="entry name" value="FERM_F1_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000003">
        <property type="entry name" value="Radixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000002">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000013">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.450:FF:000001">
        <property type="entry name" value="radixin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="28"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO38341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="602" mass="70964" checksum="B421162721775269" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP51</accession>
    <name>A0A151NP51_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0015719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP51"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="111"/>
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        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO38490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="13029" checksum="1E8BD8144D934FD5" modified="2016-06-08" version="1">MWQEAFSWQVRVDEVEEKAARLEVELEMMRSQKEQAEAKVAALELRVQPGKKEGGSKEIKRLIAAEVEKTRALERLMAEEAKKSRQRDEKLQEMQKEMAEWRRKCPEPGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQ32</accession>
    <name>A0A151NQ32_ALLMI</name>
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        <submittedName>
            <fullName evidence="5">Rhotekin isoform A</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="primary">RTKN</name>
        <name evidence="5" type="ORF">Y1Q_0019912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
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    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:actomyosin contractile ring assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic cytokinesis"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PH_rhotekin2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AHD"/>
    </dbReference>
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        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
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        <property type="entry name" value="HR1_rho-bd"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHOTEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="285"/>
            <end position="391"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="536"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="560" mass="61796" checksum="4CD5952320DDD6AC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NR01</accession>
    <name>A0A151NR01_ALLMI</name>
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        <recommendedName>
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        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002333">
        <property type="protein sequence ID" value="KYO39276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NR01"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000088">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Butyrophilin subfamily 3 member A2-like Ig-C" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO39276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="136" mass="15195" checksum="6EA95A4129A89A04" modified="2016-06-08" version="1">MLWKDVGRKQLPSTQDKIHQQADGLFAVHSAIVITEASNQNVSCSVHHPLLDQEKSARINIAGSLFLRTSPWVVALSVILAIVCIFLLLSTYYSWKQRRAKEHLQSELEKERGTSPGSSSGSVLDQSRSMVMIPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRQ1</accession>
    <name>A0A151NRQ1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transgelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IGSF9B</name>
        <name evidence="12" type="ORF">Y1Q_0017149</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the calponin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002229">
        <property type="protein sequence ID" value="KYO39380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21280">
        <property type="entry name" value="CH_TAGLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000323">
        <property type="entry name" value="Immunoglobulin superfamily member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000389">
        <property type="entry name" value="Immunoglobulin superfamily member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000245">
        <property type="entry name" value="protein turtle homolog B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000039">
        <property type="entry name" value="Transgelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF244">
        <property type="entry name" value="PROTEIN TURTLE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00890">
        <property type="entry name" value="TRANSGELIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586325" description="Transgelin" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="143"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="232"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="328"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="424"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="513"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="629"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="1403"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1067"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1217"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1352"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1240"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1358"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO39380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1579" mass="172024" checksum="1458A438C066C3D7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSR2</accession>
    <name>A0A151NSR2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="27">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">Y1Q_0006706</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 27">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="27"/>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSR2"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000042">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000409">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000542">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="6 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 27" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KYO39828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="464" mass="53198" checksum="6B8183F4939D7F63" modified="2016-06-08" version="1">MDQVEAEKFLCPLIHTSNGATQKNPEEGRASIYKSVIINTSKEIMCFSDFPIPEDFPNYMHNFKIMEYFHMYAKHFDLLKYIRFKTNVCSVIKRPDFSTTGQWDVVTETNGKQELAIFDAVLVCSGHHSDAHLPLQSFPGIEKFKGRYFHSRDYKNSQEFLDKKVIVIGIGNSGLDIAVELSYTADQVFLSTRRGAWVQRRILEEGYPTDAAYVTRFVKLLLDIMPFTMMNYFAERKLNKAFNHALYGLQPKHRFFCQHSTINDDLPNRIITGKVQVKSNVSEFTETGAIFEDGTREDNIDVVIFATGYKFSFPFLDCLKVVDNQVSLYKLVFPPHLEKPTLAFIGFVQPLGALMPISELQGRWATRVFKGLNELPSTSDMLAEITQKQEEMAKRYVKSQRHTIQVDYISYLDEIASLAGFKPNLLSLFLMDTKLAMEVFFGPCTPYQYRLRGPESGLEPEKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTB0</accession>
    <name>A0A151NTB0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0006554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002098">
        <property type="protein sequence ID" value="KYO40018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTB0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7539" checksum="BBE40B38DA5771D0" modified="2016-06-08" version="1">MAALCPSMLSQNAGASRSGARQEWWINPDSAPGSHPHVLDGNNANTELIKPANWESVLPQFKLLLSQADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTN6</accession>
    <name>A0A151NTN6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Keratin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0024439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avian keratin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001982">
        <property type="protein sequence ID" value="KYO40271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTN6"/>
    <dbReference type="STRING" id="8496.A0A151NTN6"/>
    <dbReference type="KEGG" id="amj:102568196"/>
    <dbReference type="eggNOG" id="ENOG502TE1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9428763at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003461">
        <property type="entry name" value="Keratin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31203:SF1">
        <property type="entry name" value="BETA-KERATIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02422">
        <property type="entry name" value="Keratin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0416">Keratin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO40271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="13794" checksum="87C907775AE03977" modified="2016-06-08" version="1">MSCTDLCYPSGGIACPKPYADSCNEARVRQCPDSRVVIWPPPAVVTFPGPILSNFPQDSIVGSTGVPAVGHGAAGGTALSNGIGGAGGFYGYEASLDSGGLYGYGGSLGYGGLCGYGGLSSDSGSCYSSGYCSPYSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTQ4</accession>
    <name>A0A151NTQ4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transitional endoplasmic reticulum ATPase</fullName>
            <ecNumber evidence="5">3.6.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Valosin-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Y1Q_0019431</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03002051">
        <property type="protein sequence ID" value="KYO40236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTQ4"/>
    <dbReference type="STRING" id="8496.A0A151NTQ4"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF69">
        <property type="entry name" value="TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="24">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="23">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="22">
        <location>
            <begin position="294"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="22">
        <location>
            <begin position="567"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="825"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO40236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="880" mass="97437" checksum="F326F43B481618E8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVR3</accession>
    <name>A0A151NVR3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 10R2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0009446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001862">
        <property type="protein sequence ID" value="KYO40770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVR3"/>
    <dbReference type="KEGG" id="amj:102567574"/>
    <dbReference type="eggNOG" id="ENOG502SHIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9975554at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15225">
        <property type="entry name" value="7tmA_OR10A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO40770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="309" mass="33934" checksum="A54677A307DD9963" modified="2016-06-08" version="1">MANRTWVSKFILVGFSGLADLQLLLFVLFALLYAVTLVGNALIVTVVGADRRLHTPMYFFLGALSISETCYTFAILLPMLGGLVGASRTMSRAGCAVQMYVFIGLACNNCFLLAGMGYDRYLAICHPLRYPVLMSRLVCAWLVAMALLSGLLISMGQTLFIFSLPFCGPNTIHHFFCDLLPVIRLSCTDTSLHEAVTFALSLLVIALPFGLIVLSYLYILGTILRIPSVAGWRKAFSTCASHLTVVVLHFGCASAMYLRPAMDDDSERDQLIAVSYTVVTPLLNPVVYTLRNREVQMALRRVLGRNVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX37</accession>
    <name>A0A151NX37_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-aminobutyric acid receptor subunit gamma-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0006265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Synaptic cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX37"/>
    <dbReference type="STRING" id="8496.A0A151NX37"/>
    <dbReference type="eggNOG" id="KOG3642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005437">
        <property type="entry name" value="GABRG-1/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01620">
        <property type="entry name" value="GABAARGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586443" description="Gamma-aminobutyric acid receptor subunit gamma-3" evidence="5">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO41461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11783" checksum="D7AB2FC478353172" modified="2016-06-08" version="1">MSAKLLVAFFLLSVFQACSRKVEEDEYEDVTANQKWVLAPKTQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMGSKYVSVQSWPGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX65</accession>
    <name>A0A151NX65_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0007007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001653">
        <property type="protein sequence ID" value="KYO41260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX65"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF445">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF28.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB-related" evidence="9">
        <location>
            <begin position="105"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="8">
        <location>
            <begin position="108"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB-related" evidence="9">
        <location>
            <begin position="248"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="8">
        <location>
            <begin position="251"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO41260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="461" mass="51876" checksum="3D9E3883571B81BC" modified="2016-06-08" version="1">MYETWSALTSSQQPRRCQKAPCEQWESESTGPGSGETEKTTSSKDAGTLRTAEEQPPKDRPVTLELLRPFPGRSGERGPLTPELGQVHKKQGRHPQQGENMAVSKLPEAFEDVAVYFTRKEWELLEAGDKGLYQDQMLRNYQALVSLGLQGPAPDLICRMQLGEMELWVCDDEEAGESSLSEDFSPAGAGTLSSAEEQPPEDEPGNLELLRLFPGRFGEKEPLTPEPGQIHEKQGKCSQQRENVAVSKILEAFEDVAVFFTREEWELLEAGDKGLYQNQMLRNYQALVSLGLQGPAPDLICRMQLGEMELWVCDDEEAGESSLSEDFSPADAETLGTHLCLECGESFVSPSKLRVHQDVHSGEQLYRCTECKSFTRWDHLQNHTCVHVDEKPFYCLHCGKSFTKSSKLMQHQHMHTEEKQVSCSQYRKSFTQSSKLTKHLQCGKTFTKRSSLMNHLCVHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXV9</accession>
    <name>A0A151NXV9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CLDN7</name>
        <name evidence="11" type="ORF">Y1Q_0021950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001617">
        <property type="protein sequence ID" value="KYO41722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXV9"/>
    <dbReference type="STRING" id="8496.A0A151NXV9"/>
    <dbReference type="KEGG" id="amj:102568117"/>
    <dbReference type="eggNOG" id="ENOG502QPXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10025519at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586469" description="Claudin" evidence="10">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO41722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="209" mass="21588" checksum="DE286B1EA3251974" modified="2016-06-08" version="1">MANAGLQALGLALAVLGWLALALATALPQWRVSSYAGDSIITAVAVYQGLWMSCASQSTGQVQCKTYDSVLALSASLQATRALMVVAVVLGLVALGIAIMGMKCTHCGSDDKVQKARIAMTGGLVYVVAGLAGLVACSWYGHQIVTDFYNPLVPMNAKYEFGSGIFVGWAGSALTLLGGGLLSCSCPGKSGPRAQYPKSKAASSNREYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZK7</accession>
    <name>A0A151NZK7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="25">PARP</shortName>
            <ecNumber evidence="25">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">Y1Q_0022180</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">KSC_2009_1</strain>
        </source>
    </reference>
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        <reaction evidence="23">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
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        </reaction>
    </comment>
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            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
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        <property type="match status" value="3"/>
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    <keyword evidence="9" id="KW-0879">Wnt signaling pathway</keyword>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1141" mass="124732" checksum="BA753B4700FD68E2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0V2</accession>
    <name>A0A151P0V2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0016144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001351">
        <property type="protein sequence ID" value="KYO42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0V2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7817" checksum="466E6B7D9349112D" modified="2016-06-08" version="1">MLKKRILGSVSLGTGVSKMDTLNYVMGAVLTQEVEGIERLIAYASRKFNPPERRYATIEWECLVIKWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P129</accession>
    <name>A0A151P129_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001351">
        <property type="protein sequence ID" value="KYO42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P129"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="200" mass="21882" checksum="40D2EE3666CC20E2" modified="2016-06-08" version="1">MSGLKRGHGALRGVGGGGFVGDPDGCFRNPSPKKENQNKHAPPCRYPVVKVISLNTSKEGRDASENQFLEMPEGQELDQSPLTALTQNHRNAHPKDQNPEDQDARKTEKKDMEGVSHKEVVPKNGWGVIQIVPEKTPVTGSVTPEDAEIKGLQSAIAITLSCWDNVGTSQKINAKQEKIRTNTFRNRGAATLYENILFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P354</accession>
    <name>A0A151P354_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Presenilin</fullName>
            <ecNumber evidence="11">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PSEN1-1</name>
        <name evidence="13" type="ORF">Y1Q_0013548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P354"/>
    <dbReference type="STRING" id="8496.A0A151P354"/>
    <dbReference type="GeneID" id="102572042"/>
    <dbReference type="KEGG" id="amj:102572042"/>
    <dbReference type="CTD" id="5664"/>
    <dbReference type="eggNOG" id="KOG2736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20287at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P354"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000001">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001493">
        <property type="entry name" value="Pept_A22A_PS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF24">
        <property type="entry name" value="PRESENILIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01074">
        <property type="entry name" value="PRESENILIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO43501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="458" mass="51298" checksum="B5BF1D676A7ADE46" modified="2016-06-08" version="1">MITFMNSSDSEEEPCNERTSLMSVESPPVPSYQDGLQAPEVVETQTHRKRYTGSSGSSNDVAHGNSDAELLVQDVRLDNEEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFSEDTPSVGQRLLNSVLNTLIMISVIVVMTVFLVILYKYRCYKFIHGWLILSSLMLLFLFTYIYLGEVFKTYNVAMDYPTLFFVIWNFGAVGMICIHWKGPLQLQQAYLIMISALMALVFIKYLPEWSAWVILGAISIYDLMAVLCPKGPLRMLVETAQERNEPIFPALIYSSAVMWTVGMAKPDTASRGLSQQTWDSAEDMRENHESPSHLDSEISETRNPAPSHPTASSLEELEEEERGVKLGLGDFIFYSVLVGKAAATASGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLVFYFSTDNLVRPFMDTLASHQLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3D3</accession>
    <name>A0A151P3D3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial amidoxime reducing component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MARC2-1</name>
        <name evidence="2" type="ORF">Y1Q_0013591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3D3"/>
    <dbReference type="STRING" id="8496.A0A151P3D3"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdenum cofactor sulfurase middle" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO43562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="18666" checksum="BF32301FE2AE9EBE" modified="2016-06-08" version="1">MSGVGGAAYSCGGSAVRRAELTALGLRSGDLRDRFWLVIKEDGHMVTGRQEPRLVLISVSCDNGYLTLNAPEMKELRVPVELSRKNQVHNCRIFGFDVQGRDCGDEAAEWITTFLTTEPYRLVHFEPSMMPRNSKDTMPCFRPTDKESKGSILFLFIQKILYASSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P478</accession>
    <name>A0A151P478_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Rho GTPase-activating protein 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARHGAP35</name>
        <name evidence="14" type="ORF">Y1Q_0001987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001095">
        <property type="protein sequence ID" value="KYO43813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P478"/>
    <dbReference type="STRING" id="8496.A0A151P478"/>
    <dbReference type="eggNOG" id="KOG4271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04373">
        <property type="entry name" value="RhoGAP_p190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000021">
        <property type="entry name" value="rho GTPase-activating protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057284">
        <property type="entry name" value="FF_RHG35_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039007">
        <property type="entry name" value="pG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051978">
        <property type="entry name" value="Rho-GAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045786">
        <property type="entry name" value="RhoGAP_pG1_pG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039006">
        <property type="entry name" value="RhoGAP_pG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23083">
        <property type="entry name" value="FF_RHG35_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19518">
        <property type="entry name" value="RhoGAP_pG1_pG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51852">
        <property type="entry name" value="PG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51853">
        <property type="entry name" value="PG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FF" evidence="11">
        <location>
            <begin position="216"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="11">
        <location>
            <begin position="277"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PG1 pseudoGTPase" evidence="12">
        <location>
            <begin position="363"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="PG2 pseudoGTPase" evidence="13">
        <location>
            <begin position="474"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="10">
        <location>
            <begin position="945"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="660"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="755"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="871"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1142"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1167"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO43813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1196" mass="135845" checksum="39BE1D042F715E02" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4K4</accession>
    <name>A0A151P4K4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0017392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001003">
        <property type="protein sequence ID" value="KYO43991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4K4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013017678" evidence="2">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO43991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="148" mass="16662" checksum="6E5DB72B3BE60107" modified="2016-06-08" version="1">MTVALLFLVSATVAAMFYVRHRQKAEETCFTAWWRNTLGPVQQEPPTQRLPPPAAEAATDLDPEYHNVCPRQQSRDVVYSTVTFKKGSNAKPTRTPQMDDQEHLVTYAVLPSLKPSWDSATRVRASEGGDSSRSDIYENVPHPDLHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4T4</accession>
    <name>A0A151P4T4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Junctophilin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">JPH4</name>
        <name evidence="12" type="ORF">Y1Q_0004556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the junctophilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000933">
        <property type="protein sequence ID" value="KYO44072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4T4"/>
    <dbReference type="STRING" id="8496.A0A151P4T4"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000001">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000003">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF14">
        <property type="entry name" value="JUNCTOPHILIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="424"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO44072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="526" mass="57066" checksum="C4C4AB52164509C6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P558</accession>
    <name>A0A151P558_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor RelB isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RELB</name>
        <name evidence="9" type="ORF">Y1Q_0013922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000848">
        <property type="protein sequence ID" value="KYO44192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P558"/>
    <dbReference type="STRING" id="8496.A0A151P558"/>
    <dbReference type="KEGG" id="amj:102571096"/>
    <dbReference type="eggNOG" id="ENOG502QV8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7881762at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030098">
        <property type="term" value="P:lymphocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07886">
        <property type="entry name" value="RHD-n_RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000046">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000005">
        <property type="entry name" value="RELB proto-oncogene, NF-kB subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030496">
        <property type="entry name" value="RelB_RHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032400">
        <property type="entry name" value="RelB_transact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030492">
        <property type="entry name" value="RHD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR RELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16181">
        <property type="entry name" value="RelB_transactiv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01204">
        <property type="entry name" value="REL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHD" evidence="8">
        <location>
            <begin position="133"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO44192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="578" mass="63692" checksum="6D844E4DF7335B82" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P586</accession>
    <name>A0A151P586_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome non-ATPase regulatory subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">26S proteasome regulatory subunit RPN3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">26S proteasome regulatory subunit S3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Proteasome subunit p58</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PSMD3</name>
        <name evidence="14" type="ORF">Y1Q_0012024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD3, a base containing 6 ATPases and few additional components. Interacts with UBQLN1 (via ubiquitin-like domain). Interacts with ERCC6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P586"/>
    <dbReference type="eggNOG" id="KOG2581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000174">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PCI" evidence="13">
        <location>
            <begin position="273"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="521" mass="59671" checksum="A9A80369E7D709EC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5I2</accession>
    <name>A0A151P5I2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Granulocyte colony-stimulating factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CSF3</name>
        <name evidence="7" type="ORF">Y1Q_0012023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-6 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5I2"/>
    <dbReference type="STRING" id="8496.A0A151P5I2"/>
    <dbReference type="eggNOG" id="ENOG502SCNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005130">
        <property type="term" value="F:granulocyte colony-stimulating factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045639">
        <property type="term" value="P:positive regulation of myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040117">
        <property type="entry name" value="GCSF/MGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030474">
        <property type="entry name" value="IL-6/GCSF/MGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030473">
        <property type="entry name" value="IL6/GCSF/MGF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10511">
        <property type="entry name" value="GRANULOCYTE COLONY-STIMULATING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10511:SF2">
        <property type="entry name" value="GRANULOCYTE COLONY-STIMULATING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16647">
        <property type="entry name" value="GCSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00433">
        <property type="entry name" value="IL6GCSFMGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00126">
        <property type="entry name" value="IL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00254">
        <property type="entry name" value="INTERLEUKIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO44230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="154" mass="17551" checksum="665D187931410301" modified="2016-06-08" version="1">MDVETVRQHMCDNFQLCKEEELMLVKQNLNIFQPSLNQCLSKPFQVDVCFSQIREGLQTYHGYLSTIAQLLPGHSTQVEGLQLDTSNLSTNIQQQIEALGLNMGMVTYPKEEGQGTLLTFSSQFYQQAGGYIILANFQLFLDLAYRVLRHLIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5K7</accession>
    <name>A0A151P5K7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Neurogenic differentiation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NEUROD2</name>
        <name evidence="12" type="ORF">Y1Q_0012045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275036.1">
        <property type="nucleotide sequence ID" value="XM_006274974.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5K7"/>
    <dbReference type="STRING" id="8496.A0A151P5K7"/>
    <dbReference type="GeneID" id="102566952"/>
    <dbReference type="KEGG" id="amj:102566952"/>
    <dbReference type="CTD" id="4761"/>
    <dbReference type="eggNOG" id="KOG3898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039134at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P5K7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19720">
        <property type="entry name" value="bHLH_TS_NeuroD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022575">
        <property type="entry name" value="NeuroD_DUF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016637">
        <property type="entry name" value="TF_bHLH_NeuroD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF83">
        <property type="entry name" value="NEUROGENIC DIFFERENTIATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12533">
        <property type="entry name" value="Neuro_bHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015618">
        <property type="entry name" value="bHLH_NeuroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="1 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO44260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="355" mass="40231" checksum="8EFCFD9F302FA065" modified="2016-06-08" version="1">MLTRLFSEPSLIPEVQKFSSWADDCEDDERPEKEERKGKSCPLQEEQTEGSLGENKEEGDIGGDEEEEEEEEEGLEEAEGDRPKKRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGQEAGRYHGPNSSFAMHPYTYQCSRLSGAQCQSSTMASSHALRTHAYCATYETLYGNASPDYNSSEYDGPLSPPLCINGNFSLKQDSSPDHEKNYHYSMHYSALPSSRPSGHNLVFGSSGMRGGVHSENILPYDMHLHHERGPMYEELNAFFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5R3</accession>
    <name>A0A151P5R3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Plexin domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PLXDC1</name>
        <name evidence="12" type="ORF">Y1Q_0012060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5R3"/>
    <dbReference type="STRING" id="8496.A0A151P5R3"/>
    <dbReference type="eggNOG" id="KOG3848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF10">
        <property type="entry name" value="PLEXIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586700" evidence="10">
        <location>
            <begin position="18"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="11">
        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO44279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="489" mass="54394" checksum="7DDF670C33E06F17" modified="2016-06-08" version="1">MQWGVLVLLYLLREAAGEASVHQGAGHTPGGSLEGGEPPGWRRKTRESLLETNRTRISQDLVGGSLAIDTLPDNETQIVEDNHSYYVSRIHGPGEAHIKEFWVNMAEANRSQVKIHGILSNTHRQASRVILSFDFPFYGHLLRQITIATGGFIFMGDVIHRMLTATQYIAPLMANFNPSYSRNSTVMYFDNGTVFVVQWDKVYLQGKEDIGSFTFQAALHSDGKIVFSYKEIPVSVLAISATQHPVKAGLSDAFMILNPSPDVPESRRRTIYEYHRVELDTGKITSMSAVEFSPLPTCLQHQSCEMCVTSEMTFNCSWCHVLQRCSSGFDRYREEWLSYGCGQESNEKTCEDLADGSYYSPAPDSSFTTSEEDISTSTSSMFIDSLTTEDDTKLNQYAGVDSVSSDLPSKKTGAPIHAGTIVGIVLAVLLIAAIILAGIYINSHPTSNAALFFIERRPHHWPAMKFRNHTNHTTYSEEQQPEEKGPAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6Q4</accession>
    <name>A0A151P6Q4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">28S ribosomal protein S35, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRPS35</name>
        <name evidence="4" type="ORF">Y1Q_0016854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6Q4"/>
    <dbReference type="STRING" id="8496.A0A151P6Q4"/>
    <dbReference type="eggNOG" id="KOG3933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586728" evidence="2">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="3">
        <location>
            <begin position="160"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO44742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="321" mass="36784" checksum="B6A09F40A23A7BB9" modified="2016-06-08" version="1">MLPRLRGAWTLALLQSAANSTAVPQNRSESGGTHWRRREVPRHNRLLGIPRTKKMPVDQDWSNVYPVAASFKPSVVPLPIRMGYPMKKRAPPSKEGNLELIKIPNFLHLTPGAVKKHCAALKNFCTVWPTALDSDEKCEQHFPVEIDTVDYVSAGPSIRNPKARVVTLRVKLSKLNLDDHAKKKLIKLVGERYSKDTDILTITTDRCPLRRQNYDYGIYLLTVLYHESWKTEKWESEKTDADMEEYIWENTCSQKNVLDTLLRIKAAEKISDVPREELLASEIVENYKNSVVLLKNEGETEDNMSKYKESVKKLLNLQGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7K5</accession>
    <name>A0A151P7K5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7K5"/>
    <dbReference type="STRING" id="8496.A0A151P7K5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19628" checksum="98F91E1C226B491F" modified="2016-06-08" version="1">MTQATFLGLLEQLHLHLELKETNIWQPLPTDTWLAISLLKLATSASLHYVGHLFGMGKATITEAILEVCDTLSDVLGYTMLCVHDLLAVVVGFHDLGFSQCIRALDRTHIPITCPLQRDHPYYSQWCFQSIVLQVITDHCSVFTNMSASWVDSAYNACIFQNSALPALVESECFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8Y9</accession>
    <name>A0A151P8Y9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Y1Q_0015153</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8Y9"/>
    <dbReference type="STRING" id="8496.A0A151P8Y9"/>
    <dbReference type="KEGG" id="amj:102573816"/>
    <dbReference type="eggNOG" id="KOG1307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000005">
        <property type="entry name" value="sodium/potassium/calcium exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000006">
        <property type="entry name" value="sodium/potassium/calcium exchanger 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF21">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586806" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="21">
        <location>
            <begin position="25"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="22">
        <location>
            <begin position="88"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="22">
        <location>
            <begin position="416"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO45494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="584" mass="65462" checksum="7D128AEBCBCEC70A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAX3</accession>
    <name>A0A151PAX3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAX3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="99" mass="11438" checksum="3C8FEA9A2B1D2A1A" modified="2016-06-08" version="1">MTQLLVTMLYGFVPLSQQPSIPHGATHHNLCLPSILDYFNETEEDKATQDAMDTRVFWHRCQTIMCQATQVFINHKGYLPIILQGIINYQICFIYIFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PB42</accession>
    <name>A0A151PB42_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PB42"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="7971" checksum="F3480C4C0C52FE6E" modified="2016-06-08" version="1">MEPQLRIQSKGVHKARVNLRTGVFPAEDPEEGLKGKNLQSQAKTGPWKGVPKRGTRTPCGAEKVTTGSTETWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBR3</accession>
    <name>A0A151PBR3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAT complex subunit CCDC47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CCDC47</name>
        <name evidence="10" type="ORF">Y1Q_0018337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Rough endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCDC47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBR3"/>
    <dbReference type="STRING" id="8496.A0A151PBR3"/>
    <dbReference type="eggNOG" id="KOG2357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO46546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="533" mass="61024" checksum="7EEDCF7832A13DB8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBW5</accession>
    <name>A0A151PBW5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">RING-type E3 ubiquitin transferase BRCA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="primary">BRCA1</name>
        <name evidence="37" type="ORF">Y1Q_0018281</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="37">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBW5"/>
    <dbReference type="STRING" id="8496.A0A151PBW5"/>
    <dbReference type="eggNOG" id="KOG4362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043009">
        <property type="term" value="P:chordate embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17735">
        <property type="entry name" value="BRCT_BRCA1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17721">
        <property type="entry name" value="BRCT_BRCA1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING-HC_BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Breast cancer type 1 susceptibility protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000006">
        <property type="entry name" value="Breast cancer type 1 susceptibility protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000025">
        <property type="entry name" value="Breast cancer type 1 susceptibility protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031099">
        <property type="entry name" value="BRCA1-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001734">
        <property type="entry name" value="BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="20" id="KW-0007">Acetylation</keyword>
    <keyword evidence="24" id="KW-0010">Activator</keyword>
    <keyword evidence="30" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="33" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="27" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="28" id="KW-0234">DNA repair</keyword>
    <keyword evidence="23" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="25" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="29" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="26" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15 32" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="35">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="36">
        <location>
            <begin position="648"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="36">
        <location>
            <begin position="730"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="273"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="33">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="34">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="34">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00031556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="KYO46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="832" mass="93447" checksum="BB794AD49728388C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDC1</accession>
    <name>A0A151PDC1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDC1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10635" checksum="52167EC1006F8DB9" modified="2016-06-08" version="1">MTALIPAKGQAQGYTGGYQTPPDFQSKKQGGIKRSRKMQKCTTFHKCSQIKWKQTKMFYQSNRSVSVQDMTSVRIFAHFCRHFHRKMETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE32</accession>
    <name>A0A151PE32_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000474">
        <property type="protein sequence ID" value="KYO47278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PE32"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="9212" checksum="8FF3CE8167BCB496" modified="2016-06-08" version="1">MLLWERRLPSSESPVRLTWVRHPLLGMLQGRHGQCGRDSGNHREVTEWSDSAMKQWVAVELIHFPGPSTRHPVHVPPLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHH1</accession>
    <name>A0A151PHH1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0010604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000242">
        <property type="protein sequence ID" value="KYO48225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHH1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051896">
        <property type="entry name" value="TCR_alpha_variable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19339:SF2">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19339">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1279">T cell receptor</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007587052" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO48225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="12195" checksum="E702D17A75AC8F96" modified="2016-06-08" version="1">MRLQLRALCLLCAVFCCGAQVSQSPEALVTREGDHSTMACAYSSAFQTFQWYRQVPSGVITHLLSVPTNRNITEGLFTGESREDGKKGSLHLSQTQMGDSGRYFCAVQDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LY76</accession>
    <name>A0A151LY76_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Methylcytosine dioxygenase TET</fullName>
            <ecNumber evidence="18">1.14.11.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0007683</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 18">
            <text>a 5-formyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53832"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="Rhea" id="RHEA-COMP:13657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="ChEBI" id="CHEBI:137732"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:53828"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 5-methyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:52636"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="18">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">The zinc ions have a structural role.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the TET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.80" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03007073">
        <property type="protein sequence ID" value="KYO17204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151LY76"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070579">
        <property type="term" value="F:DNA 5-methylcytosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141166">
        <property type="term" value="P:chromosomal 5-methylcytosine DNA demethylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18897">
        <property type="entry name" value="TET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040175">
        <property type="entry name" value="TET1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046942">
        <property type="entry name" value="TET_oxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23358:SF4">
        <property type="entry name" value="METHYLCYTOSINE DIOXYGENASE TET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01333">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 18" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="20">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51058"/>
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            <dbReference type="EMBL" id="KYO17204.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
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    <sequence length="2028" mass="220310" checksum="D9EF3BC46A138E18" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYA2</accession>
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            <fullName evidence="5">Immunoglobulin domain-containing protein</fullName>
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        <name evidence="6" type="ORF">Y1Q_0011010</name>
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    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ig-like_Receptors_ImmuneReg"/>
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        <property type="entry name" value="Ig_sub"/>
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        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
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    <sequence length="145" mass="15631" checksum="98FC3834845DE395" modified="2016-06-08" version="1">MGPTPAFLVLLGAMWTCLLSAAPQAFPAPSISLIPSGSIIPGTNMIIRCWADLSGMRFLLYKVGVLDALRHVEPAGNKGEFPITNARQEDSGNYTCRYQTLDEPPKWSYHSNPVELVVKGEILCSLESRHPSSQPHSPSGTGIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZ78</accession>
    <name>A0A151LZ78_ALLMI</name>
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        <name evidence="1" type="ORF">Y1Q_0020139</name>
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    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
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                <person name="Ray D.A."/>
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            <dbReference type="PubMed" id="22293439"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZ78"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO17553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="89" mass="10067" checksum="FD7AB51EAFFE58B8" modified="2016-06-08" version="1">MCPDKVSEGDTQVTLQNFTNSRFTDEEQACKEFITDKTKMIFHLIPSLAMASKSSSDTRPFWTAAPWKANLNYLCASGKSPSDFRRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZV7</accession>
    <name>A0A151LZV7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pleckstrin-like proteiny domain-containing family A member 3 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PLEKHA3</name>
        <name evidence="8" type="ORF">Y1Q_0011456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006257893.2">
        <property type="nucleotide sequence ID" value="XM_006257831.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZV7"/>
    <dbReference type="STRING" id="8496.A0A151LZV7"/>
    <dbReference type="GeneID" id="102558749"/>
    <dbReference type="KEGG" id="amj:102558749"/>
    <dbReference type="CTD" id="65977"/>
    <dbReference type="eggNOG" id="ENOG502QPTX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01247">
        <property type="entry name" value="PH_FAPP1_FAPP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000085">
        <property type="entry name" value="Pleckstrin homology domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO17776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="302" mass="34193" checksum="A462A2CC4C96FFF4" modified="2016-06-08" version="1">MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHPTDNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETNESLKTKMSELRLYCDLLMRQVHTIQEFVHQDETCSSPSIENLNEASSLLSATCNTFITTLEECVKIANSKFKPEMFQLPHPDPLVSPVSPSPVQMMKRSISHPGTCSSDSCRSSHSVKEPVSSVHRLSQRRRRTYSDTEFYNDVPLEDTERSAHCSRSTLNGDLAVSTIPEENKSVSMKKSELEETLAFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M007</accession>
    <name>A0A151M007_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox protein Hox-D1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXD1</name>
        <name evidence="14" type="ORF">Y1Q_0011476</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Antp homeobox family. Labial subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M007"/>
    <dbReference type="STRING" id="8496.A0A151M007"/>
    <dbReference type="GeneID" id="106738345"/>
    <dbReference type="KEGG" id="amj:106738345"/>
    <dbReference type="CTD" id="3231"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000113">
        <property type="entry name" value="homeobox protein Hox-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO17800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11805" checksum="679C16BA01C9D228" modified="2016-06-08" version="1">MKVKRNAPRKSKAAAPGAASAARTSFSTRQLTELEKEFHFNKYLTRARRLEIARALQLHDTQVKIWFQNRRMKQKKREREGLLPPARRAAGTPEPCPAARDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M193</accession>
    <name>A0A151M193_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M193"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="132" mass="14954" checksum="28E66AEC3EEA7E6F" modified="2016-06-08" version="1">MTVLMQLVPLRRDDMLQCDVLNVSQVALRGGTAGILPSVLAALQSPWRRLQSPLGRNLFLLYTLQFSVCNTKFTSLDEVENENPNFWKFHLAKTNGKSWTYAVHIIQNESHADRSKCQLIFTTSLQDARAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1J0</accession>
    <name>A0A151M1J0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinase kinase kinase</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0008507</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1J0"/>
    <dbReference type="STRING" id="8496.A0A151M1J0"/>
    <dbReference type="eggNOG" id="KOG0576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06613">
        <property type="entry name" value="STKc_MAP4K3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000031">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021160">
        <property type="entry name" value="MAPKKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF17">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038172">
        <property type="entry name" value="MAPKKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="15">
        <location>
            <begin position="519"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="381"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO18385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="857" mass="97343" checksum="A2E4AD33212D8715" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1N1</accession>
    <name>A0A151M1N1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tripartite motif-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1N1"/>
    <dbReference type="STRING" id="8496.A0A151M1N1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="68"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="227" mass="26312" checksum="EFCCBF580A78DB6F" modified="2016-06-08" version="1">MISEMEGKRQQPGTEFLQDIRSTLNRCEKKGKFLQPIIYFPELEKNLNSFCQQRTAVKKTLRIFKDSLSIELLKERSKPLRPDKKVNMTLDPDTANPHLTFSTDHKSVIWERVVQNLPDKPERFDPIPCVLGSEGFISGRHHWEVEIRGHRVKKSKEEAMTCLRDGVGAEHRLKDGMLATAAAFYRELYAGKPVDPEAMQLCLQSLTQTLGEDEQWQLEEDWMQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1S7</accession>
    <name>A0A151M1S7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1S7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10523" checksum="364B14862F81C418" modified="2016-06-08" version="1">MFHNFGLTGLVNSGPFVQGVLDLQLGAIAVPPFLIGDPAYLLLSWLMWLYTNHLDPRKTHNCWTKGYLTHYMLLLLIFMVLQEHLVWEPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3T1</accession>
    <name>A0A151M3T1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0003399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006683">
        <property type="protein sequence ID" value="KYO19175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3T1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23572">
        <property type="entry name" value="TFP_LU_ECD_PINLYP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050918">
        <property type="entry name" value="CNF-like_PLA2_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914:SF9">
        <property type="entry name" value="COILED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914">
        <property type="entry name" value="LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="UPAR/Ly6" evidence="4">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="4">
        <location>
            <begin position="145"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="4">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO19175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="455" mass="48897" checksum="3178A977CCA8E9A3" modified="2016-06-08" version="1">MPQSRDFLSQLPTRRYCPVSQRKSPVRLGTVPNIMQGIWALLLLSALFGLAAGQGSRSCACMPKVGNCTSGNQTCQEKEKFCIAVASEDRVYYKACSINCKNQIVTMSVGNQNLLQVTNFCCNETDCNKYTAPLPAAPISKLKNGVLCNACQNLTNANCSTTVIECMGNEDKCFKATGTEKNTKTNFVLMGCATSNINELAAKDVIFIKDKLYELSGAPSNETIIPTTTTPATVPSRTTSGASQLPGKGSFTLLLSSVMNPEIQSPAWMTLLHFTFLSALIACGQGKEDTGYHLSCVTPSTIPGNIALFFGNDFYLKIWFRTCTTSNCNNIFSPDKDLAISNMYNGKACSSCYAPGHKSCGNNGTIRCEGAIDQCAYITGTVSEGNITIPFAARGCASEGACNIKPNYQLKSGVFRYVFETVNCSPAPSSAVQTRVWGSHLLPSLAGLLLVKSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4G9</accession>
    <name>A0A151M4G9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Low-density lipoprotein receptor class A domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LDLRAD1</name>
        <name evidence="10" type="ORF">Y1Q_0003532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
        <property type="protein sequence ID" value="KYO19396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4G9"/>
    <dbReference type="STRING" id="8496.A0A151M4G9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057430">
        <property type="entry name" value="LDLRAD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25241">
        <property type="entry name" value="LDLRAD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="LDLRAD1-like C-terminal" evidence="9">
        <location>
            <begin position="183"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO19396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="226" mass="25567" checksum="52F4ACC4EF7E8262" modified="2016-06-08" version="1">MASSSGRPIQGLRDSYKRHLCYNQRFFDGIPSDSRKLFSEERDCCKECTAWLRCTRRCVCVSAVALFVLGIIAAIIGLAVTFGIPPRTPVNRFCVTSNNRTGFLCDDRESCIPAHQVCNRIRECANGEDEQETLCSDLPNSLPGYLIFRCSYPSYWIYADKRCNGFNDCGDCSDEMGTLAGCPPCGPQWWSCTPVFYEYCTCVPRSFCRDGVQHCTSWSDEYICMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5R8</accession>
    <name>A0A151M5R8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GNL1</name>
        <name evidence="8" type="ORF">Y1Q_0006827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006526">
        <property type="protein sequence ID" value="KYO19863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5R8"/>
    <dbReference type="STRING" id="8496.A0A151M5R8"/>
    <dbReference type="eggNOG" id="KOG1424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="179"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO19863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="616" mass="69965" checksum="7DAC027077367D88" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8S5</accession>
    <name>A0A151M8S5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO20917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8S5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7355" checksum="ABE1E3C38550CAFE" modified="2016-06-08" version="1">MPSGNRGAPCLRALQMGQQQCTMILEKGPLPGHHAGPPLYSLRLMKTNEQGLDVLKQILLEAPDPGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8V9</accession>
    <name>A0A151M8V9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calmodulin-like protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CALML4</name>
        <name evidence="9" type="ORF">Y1Q_0001268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Acts as a light chain for MYO7B and is required for efficient targeting of the IMAC to the tips of border brush microvilli.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with MYO7B; the interaction mediates the association of CALML4 with the IMAC/intermicrovillar adhesion complex. Interacts with MYO7A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO20935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014450757.1">
        <property type="nucleotide sequence ID" value="XM_014595271.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8V9"/>
    <dbReference type="STRING" id="8496.A0A151M8V9"/>
    <dbReference type="GeneID" id="102577125"/>
    <dbReference type="KEGG" id="amj:102577125"/>
    <dbReference type="CTD" id="91860"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M8V9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000191">
        <property type="entry name" value="Calmodulin like 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF45">
        <property type="entry name" value="CALMODULIN LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO20935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="153" mass="17842" checksum="DE88DD66C95A09FA" modified="2016-06-08" version="1">MAKFLSQDQINEFKECFSLYDNNHKGKIKASDLITVMRCLGASPTPSEVDKHLLWHKIDRRAELDFSTFLNIMYRQMQQEDPQQEIRTAMAMIDRQKKGFIPVSELRAKLTKMGEKLSEEEVDDLLKEAKVGPNGIIKYEDFIRRITIPVTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M914</accession>
    <name>A0A151M914_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M914"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="94" mass="10424" checksum="CD6DE2302DFF8239" modified="2016-06-08" version="1">MSKRLASVPFLWTSFQRQRTVPKARARVPGSRPVHKGPGKRCFSWTGTSRSASQALSLDQGRLALITLHDFKCCGKVASRPFTTTTQDVLVRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAS0</accession>
    <name>A0A151MAS0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAB29</name>
        <name evidence="8" type="ORF">Y1Q_0003370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Lipid-anchor</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006286">
        <property type="protein sequence ID" value="KYO21626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267871.1">
        <property type="nucleotide sequence ID" value="XM_006267809.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAS0"/>
    <dbReference type="STRING" id="8496.A0A151MAS0"/>
    <dbReference type="GeneID" id="102564432"/>
    <dbReference type="KEGG" id="amj:102564432"/>
    <dbReference type="CTD" id="8934"/>
    <dbReference type="eggNOG" id="KOG4423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000222">
        <property type="entry name" value="RAB32, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF42">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7L1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO21626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="205" mass="23225" checksum="2DF44D421FE8C4E6" modified="2016-06-08" version="1">MRHHDRMFKVLIVGDVTVGKTSLVQRYANDSFNKHYKSTVGVDFALKVVQWSESEIIRLQLWDIAGQERFTSMTRLYYREASACVIMFDVTNTSTFKNSQKWKQDLDSKLTLPNGSPVPCLLLANKSDLSPWAVTREEIDRFSKENGFSGWIETSVKDNKNINESMRVLVEKMMSSSTGDRDSSVSGQGDYINLKDASSPGWACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBS3</accession>
    <name>A0A151MBS3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBS3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="119" mass="13768" checksum="8DA2CD2E4C63CF0C" modified="2016-06-08" version="1">MWRWNSVTTRTFTYVFNFYKDVIIVWSLSLTLKMKSPEEMLSMCFAEQFWKTSQHDALKIQGCVIPDVLSSLLEKRGAVKKTVKKWINCKTRHLGKLMDISKELGQLSSEATENSCQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCA8</accession>
    <name>A0A151MCA8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Synaptotagmin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Synaptotagmin I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SYT8</name>
        <name evidence="19" type="ORF">Y1Q_0000760</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Chromaffin granule membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCA8"/>
    <dbReference type="STRING" id="8496.A0A151MCA8"/>
    <dbReference type="GeneID" id="102564474"/>
    <dbReference type="KEGG" id="amj:102564474"/>
    <dbReference type="CTD" id="90019"/>
    <dbReference type="eggNOG" id="KOG1028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042584">
        <property type="term" value="C:chromaffin granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000007">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000016">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF249">
        <property type="entry name" value="SYNAPTOTAGMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0564">Palmitate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="107"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="238"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO22167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="396" mass="44827" checksum="65FD56430394FFA9" modified="2016-06-08" version="1">MASKTSSSTMIASPVPTNATGTTTAQPSFIEGIINEIPLPKWALIAIVVAAGLVCILILICIIKCCCCKKKRKKKEKLNLVNFNGSTTASLVQPDMDDLESGLEDEKRGRLQYSLEYNFRSQEMKVGVKQAADLKAMDSGGTSDPYVIVYLTSDIKKKYETKVYRKMLNPVFNESFTFQIPQAEMSESTLVMQVYDFNRFARHDIIGEVRLPLSNVDLQHVMEQWNELVAASKTEQEHLGEICFSLRYVPTTSKLTVVILEAKKLKKMDSHGLTDPYVKVQLILNKRKWKKKKTSVKKSTLSPYFNEAFVFDVPFSQIQNVDLVIAVWDYDKVTKNEQIGKVFLGCRATGNHLRHWSDMLANPRRPIAQWHSLQSAEEVDNALGLKTHFKLPLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCG6</accession>
    <name>A0A151MCG6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPS13</name>
        <name evidence="8" type="ORF">Y1Q_0000699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCG6"/>
    <dbReference type="STRING" id="8496.A0A151MCG6"/>
    <dbReference type="eggNOG" id="KOG0400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO22090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="147" mass="16860" checksum="33C6128635181A18" modified="2016-06-08" version="1">MGRMKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCG7</accession>
    <name>A0A151MCG7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KIAA1755</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006240">
        <property type="protein sequence ID" value="KYO22226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCG7"/>
    <dbReference type="STRING" id="8496.A0A151MCG7"/>
    <dbReference type="eggNOG" id="KOG4240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052231">
        <property type="entry name" value="Rho_GEF_signaling-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45845:SF2">
        <property type="entry name" value="RIKEN CDNA D630003M21 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1277" mass="137363" checksum="71D66C4B51C9024D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDN6</accession>
    <name>A0A151MDN6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDN6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="9208" checksum="B2B2A86C2C37030C" modified="2016-06-08" version="1">MVLIKYYQAISDDASSIFTLSEFSVQKSGKANNKCLVVIWTLSRLRTIYMSSYADLHFQLWIRFSEQLQSWKPGNHDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDU2</accession>
    <name>A0A151MDU2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chondrolectin isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CHODL-1</name>
        <name evidence="11" type="ORF">Y1Q_0003201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDU2"/>
    <dbReference type="STRING" id="8496.A0A151MDU2"/>
    <dbReference type="GeneID" id="102561365"/>
    <dbReference type="CTD" id="140578"/>
    <dbReference type="OrthoDB" id="5797898at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MDU2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03595">
        <property type="entry name" value="CLECT_chondrolectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000006">
        <property type="entry name" value="Layilin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051505">
        <property type="entry name" value="C-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789:SF1">
        <property type="entry name" value="CHONDROLECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789">
        <property type="entry name" value="CHONDROLECTIN VARIANT CHODLFDELTAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585042" evidence="9">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="36"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO22694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="290" mass="31960" checksum="AAB572A804C645B1" modified="2016-06-08" version="1">MGAGPLPLVLGAALLCAPAGLCLRVLSGQKVCYGDFKHPCYKIAYFQDVSRRVGFPEARQACKIDGGALLSLESEVEQKLIENMLQNLTKSGSGISDGDFWIGLWRSGEGQATSNACPDLYQWADGSTSPFRNWYTDEPSCGSEACVVMYHQPTAIPGLGGLYLYQWNDDRCNMKHNYICKYGPDYVLEKELGDRAEPDYEVFPPVTSGSPSDASKPEDHYHVVVTETGLIPNLIYVVIPTIPLLLLILVAFGTCCFQMLHKSKGRTKTSPNQSTLWISKNTRKDSSMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDV9</accession>
    <name>A0A151MDV9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDV9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="12507" checksum="6DF7DD5F48A1E621" modified="2016-06-08" version="1">MQDQGQNPEDNFLCYAGIPCGRLEEDGTLFLSASAWLQQLPSPCMHGNSSKNSEEEILPELLRGPIVLSDNLVHVHRGKRDGQSRIERRFISILNMSKSTQEIHPSQSFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEA2</accession>
    <name>A0A151MEA2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcriptional regulator ERG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0003310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEA2"/>
    <dbReference type="STRING" id="8496.A0A151MEA2"/>
    <dbReference type="eggNOG" id="KOG3806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08540">
        <property type="entry name" value="SAM_PNT-ERG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000010">
        <property type="entry name" value="Fli-1 proto-oncogene, ETS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000039">
        <property type="entry name" value="Friend leukemia integration 1 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF216">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ERG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PNT" evidence="11">
        <location>
            <begin position="113"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="9">
        <location>
            <begin position="311"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO22837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54028" checksum="B1D4B680407C46E7" modified="2016-06-08" version="1">MASTIKEALSVVSEDQSLFECAYGTPHLTKTEMTASSSSEYGQTSKMSPRVPQQDWLSQPPTRVTIKMECNPNQVNGSRNSPDDCSVAKGGKMVGSSDTVGMNYGSYMEEKHVPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVDILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGATFIFPNTSVYPEATQRITTRPDLPYDQARRSAWTTHSHPAPQSKATQPSSAAVSKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSMYKYPSDLPYMSSYHAHPQKMNFVAPHPPALPVTSSSFFPAPNPYWNSPTGSIYPNTRLPATHMPSHLGTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEY0</accession>
    <name>A0A151MEY0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ectonucleoside triphosphate diphosphohydrolase 8</fullName>
            <ecNumber evidence="5">3.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Y1Q_0005542</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36795"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.5" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEY0"/>
    <dbReference type="STRING" id="8496.A0A151MEY0"/>
    <dbReference type="eggNOG" id="KOG1386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000002">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000068">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF31">
        <property type="entry name" value="ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="282"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO23077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="569" mass="62607" checksum="F6C9303354A67E30" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFT6</accession>
    <name>A0A151MFT6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Retinoic acid receptor RXR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nuclear receptor subfamily 2 group B member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0005761</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Heterodimer; with a rar molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFT6"/>
    <dbReference type="STRING" id="8496.A0A151MFT6"/>
    <dbReference type="eggNOG" id="KOG3575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5873264at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06956">
        <property type="entry name" value="NR_DBD_RXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06943">
        <property type="entry name" value="NR_LBD_RXR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000002">
        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000005">
        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021780">
        <property type="entry name" value="Nuc_recep-AF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11825">
        <property type="entry name" value="Nuc_recep-AF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="136"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="250"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO23379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="485" mass="53282" checksum="140D62B441989D93" modified="2016-06-08" version="1">MSTTVLSRDFSNQVNSTSLNSPTSRGPMAAPSLHPSIGPGIGSPLGSAGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPSTPNLGFGTGSPQLNSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGTMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREGMEHHPSRPTRLLGRQEEQAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYIEANMGLTPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPDQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGF2</accession>
    <name>A0A151MGF2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Echinoderm microtubule-associated protein-like 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0002239</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat EMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MGF2"/>
    <dbReference type="eggNOG" id="KOG2106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000040">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000042">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000044">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000024">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000035">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000037">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF52">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="53"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="328"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="719"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="1406"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="1690"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1690"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1766"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1923"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1321"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1321"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO23594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1958" mass="218246" checksum="DCF5597F74260D62" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIB6</accession>
    <name>A0A151MIB6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARPC5</name>
        <name evidence="6" type="ORF">Y1Q_0004273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIB6"/>
    <dbReference type="STRING" id="8496.A0A151MIB6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000006">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO24229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="141" mass="15638" checksum="5026C0E65C0BAA1B" modified="2016-06-08" version="1">MHRNDTKDNDHIEMMDCSIGKSTWEEKKEKPIIWAKVKGNMMAALQAALKNPPINTKSQAVKDRAESIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAVLLQWHEKALAAGGVGSIVRVLTARKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK36</accession>
    <name>A0A151MK36_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibroleukin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0023713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK36"/>
    <dbReference type="eggNOG" id="KOG2579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072377">
        <property type="term" value="P:blood coagulation, common pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO24829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="369" mass="41942" checksum="D4BCD2ED0F610F5D" modified="2016-06-08" version="1">MEFRQILKQAGEGHSKPSPSRARNLLDRLQTVEASVAAVASRLQRLQEENKLNLSRVEERLDSLVVLLMGILSGCKLSCDDSVLKTSILESRRLKTLETKEEAHLVLKGMGQVGAQDLGKEHKAEKTPASLVEASKKPDQSFPRDCAEIYKQGIHENGIYTIQPIPLRQPFEAYCDMVTDGGGWTVFQRRQDGSLDFNRTWQEYCLGFGSLQGEHWLGNEQLHGLTHLGQHTLRVELEDWYGVQRHAIYLKFKIASEANKYRLTAREYQGNAGNALSYSHHYNHDHKCFTTWDSDNDNYPMGNCGAYYGAGWWFDSCLAANLNGKYHRGQYSGVTSGIYWGTWYILTDKKTNQKYSFKKAEMKTRPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK71</accession>
    <name>A0A151MK71_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0023783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK71"/>
    <dbReference type="STRING" id="8496.A0A151MK71"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15451">
        <property type="entry name" value="7tmC_mGluR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06376">
        <property type="entry name" value="PBP1_mGluR_groupIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000009">
        <property type="entry name" value="Glutamate receptor, metabotropic 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000176">
        <property type="entry name" value="metabotropic glutamate receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001883">
        <property type="entry name" value="GPCR_3_mGluR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01057">
        <property type="entry name" value="MTABOTROPC7R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00979">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="509"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO24916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="842" mass="94301" checksum="0255B2226E2E8D91" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ML56</accession>
    <name>A0A151ML56_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotic recombination protein REC114 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">REC114</name>
        <name evidence="2" type="ORF">Y1Q_0009993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005879">
        <property type="protein sequence ID" value="KYO25264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019354874.1">
        <property type="nucleotide sequence ID" value="XM_019499329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ML56"/>
    <dbReference type="STRING" id="8496.A0A151ML56"/>
    <dbReference type="GeneID" id="102566650"/>
    <dbReference type="KEGG" id="amj:102566650"/>
    <dbReference type="CTD" id="283677"/>
    <dbReference type="eggNOG" id="ENOG502S157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6479200at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029168">
        <property type="entry name" value="REC114L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34921">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34921:SF1">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15165">
        <property type="entry name" value="REC114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="249" mass="27660" checksum="5B700BA6FA1CA633" modified="2016-06-08" version="1">MAAATSLSSAGAWPLRRYGRFVRSGPPHGQAAAATTAASGAWTVLESNEESGHLILTIIVSGHFFISQGRTVLEGFSLISAHTWLKIVRRTDCLLFGSRSKNECRMFRVQFDGDSKEQAVEHCCNCVQKLAEYVTVQVTDEQSQELQGQSQLPDSESQMQQHASIPPGPSWMLEEPPLQLYTNIPEARRSVVQLAQSVLNSKSELPHAYQHCVWSAKDLGPFIRLCLMDQNFPAFVEEVEKELKKLTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLI5</accession>
    <name>A0A151MLI5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005795">
        <property type="protein sequence ID" value="KYO25421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLI5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="8007" checksum="3BF1122109E409AF" modified="2016-06-08" version="1">MLSPQEGTVPHRQSGFLFSPRPHKVSLQVLGQAGSRERIYHTELSMELRNEVLDLLALHGRQKHKKFWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMA8</accession>
    <name>A0A151MMA8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NCAPH</name>
        <name evidence="13" type="ORF">Y1Q_0001834</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005679">
        <property type="protein sequence ID" value="KYO25678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019354509.1">
        <property type="nucleotide sequence ID" value="XM_019498964.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019354510.1">
        <property type="nucleotide sequence ID" value="XM_019498965.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019354511.1">
        <property type="nucleotide sequence ID" value="XM_019498966.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMA8"/>
    <dbReference type="STRING" id="8496.A0A151MMA8"/>
    <dbReference type="GeneID" id="102574181"/>
    <dbReference type="CTD" id="23397"/>
    <dbReference type="eggNOG" id="KOG2328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="550"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO25678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="723" mass="80224" checksum="ACBBF3D18A1A74C1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNW1</accession>
    <name>A0A151MNW1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0006972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005642">
        <property type="protein sequence ID" value="KYO26237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNW1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052685">
        <property type="entry name" value="Apoptosis_Repressor_CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22797">
        <property type="entry name" value="CARD6/NUCLEOLAR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22797:SF36">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="3">
        <location>
            <begin position="301"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB-related" evidence="5">
        <location>
            <begin position="492"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="4">
        <location>
            <begin position="495"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO26237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="555" mass="61060" checksum="44F1B57167E52224" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MP35</accession>
    <name>A0A151MP35_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0013418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005650">
        <property type="protein sequence ID" value="KYO26233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MP35"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB-related" evidence="3">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO26233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10443" checksum="C794F5A70AD3590C" modified="2016-06-08" version="1">MSAPTFWWGAGTLSRAEQQLPEEGPGNLELQRTSPGRPEERSSLTPEPGQVQRGQGKPPKQEESWELREVFEDVAVYFSRKEWELLEDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRL4</accession>
    <name>A0A151MRL4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0006645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005296">
        <property type="protein sequence ID" value="KYO27175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRL4"/>
    <dbReference type="STRING" id="8496.A0A151MRL4"/>
    <dbReference type="eggNOG" id="ENOG502SI4A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO27175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="148" mass="16822" checksum="4493D4744EB25365" modified="2016-06-08" version="1">MPSRFCGQNEIDHFTCEVLAVMKLVCSDTSKNQVFMFASASFTLLAPFFFIVFSYMRIIITILQIRSVDGRSKAFSTCGSHLTVVTLFYGTAIFMYLRPQSKSSQVQDKFISVFYGVLTPMLNPLIYTLRNQEVKGALRRMAEKKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTS2</accession>
    <name>A0A151MTS2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase 48</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">USP48</name>
        <name evidence="18" type="ORF">Y1Q_0023296</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03005052">
        <property type="protein sequence ID" value="KYO27915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014456654.1">
        <property type="nucleotide sequence ID" value="XM_014601168.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTS2"/>
    <dbReference type="STRING" id="8496.A0A151MTS2"/>
    <dbReference type="GeneID" id="102559136"/>
    <dbReference type="KEGG" id="amj:102559136"/>
    <dbReference type="CTD" id="84196"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02668">
        <property type="entry name" value="Peptidase_C19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01795">
        <property type="entry name" value="Ubl_USP48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000029">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 48 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033841">
        <property type="entry name" value="Pep_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044743">
        <property type="entry name" value="Ubl_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="89"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="17">
        <location>
            <begin position="459"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="17">
        <location>
            <begin position="712"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="15">
        <location>
            <begin position="950"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="611"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="881"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="907"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO27915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1036" mass="119249" checksum="42350D949D0A03B6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU72</accession>
    <name>A0A151MU72_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0005072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005047">
        <property type="protein sequence ID" value="KYO28073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MU72"/>
    <dbReference type="STRING" id="8496.A0A151MU72"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050516">
        <property type="entry name" value="Olfactory_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26452">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO28073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="155" mass="16765" checksum="108B46A83F018D98" modified="2016-06-08" version="1">MYLLSLCGNAAVAVIVCTNCSLHTPVYFFLANLAVLEICYSSVIAPLALANLLYGRKATISLAGCGTQMFFFVFLGGADCILLAVMAFDRYEVEKHKEKDAPPTLRRKQEGMKLASFLDSAKEMAEASCLPLGCAELPVSSGLLQILHPYEGSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MW07</accession>
    <name>A0A151MW07_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0013914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004844">
        <property type="protein sequence ID" value="KYO28628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MW07"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585508" evidence="2">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO28628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="228" mass="23879" checksum="4DC69B1B88DCF35F" modified="2016-06-08" version="1">MRTSPCPGAALFFSPVCGPWLVARAGLAACSIAHCGPKACDGGDEGSDIQAMASSGPGPSGSSPQSQGGDRGSPALPGHPPAGSLEPLGAQMVPGAFPDIYDGDSRQWEAHFRGIQRAYQELGKAEDFAIRVLTEDFTLPFPFAWPPASPPDCASCSFFLRPGCPVPRFLQPLHTTAQAFVKKRQLEQLALRYAHQAGTAMETGATPTSPREPTADGRGPAQPHCSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX09</accession>
    <name>A0A151MX09_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrin alpha-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">CD49 antigen-like family member A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminin and collagen receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">VLA-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Y1Q_0009893</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21. Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 23">Membrane</location>
            <topology evidence="1 23">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 23">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX09"/>
    <dbReference type="STRING" id="8496.A0A151MX09"/>
    <dbReference type="eggNOG" id="KOG3637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01469">
        <property type="entry name" value="vWA_integrins_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000001">
        <property type="entry name" value="Integrin subunit alpha 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000012">
        <property type="entry name" value="Integrin, alpha 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1460:FF:000001">
        <property type="entry name" value="Integrin, alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF22">
        <property type="entry name" value="INTEGRIN ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 23" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 23" id="KW-0401">Integrin</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1100"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="22">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="24">
        <location>
            <begin position="128"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="22">
        <location>
            <begin position="430"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="22">
        <location>
            <begin position="510"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="22">
        <location>
            <begin position="572"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00079515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00080515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO29093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1137" mass="126866" checksum="8B2C657EB1375418" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX11</accession>
    <name>A0A151MX11_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX11"/>
    <dbReference type="STRING" id="8496.A0A151MX11"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="242" mass="28268" checksum="ED27E925E5C2F6F9" modified="2016-06-08" version="1">MNFTLRVFEGVSKALGIKHLKTAVYHPQTDALVECFNQTLKQMLKKFVAESPQDWDKMIPPLLSVVREAPQASTGFSPFELLYGRQPRGILNLIKEGWEEQRDKDQNLIQYVIQLRERLEAARSEVIGNLREAQQRQVRYYSRGTRERKFEVGDHVLVLLPDWESKLLAQWQGSYEVIRQVGPLDYEVYQVDKQKKKQVYHINLLKKWEDRECMYLVPHPEELELGPSLTEESEPGNVELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXD2</accession>
    <name>A0A151MXD2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXD2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="225" mass="24578" checksum="4E1B3B6E8F78786C" modified="2016-06-08" version="1">MLKGWTTTSDDKIRDPRSIVPTLHKPEEQKVTEDMGIMNAGHPAGEDVGEVALVVNILQDNQEVALEVDECLGNLGWAEDGDMGAVHGPHAVGEAHAAEDGDYLLRANEAFDRDFLNNQRYFLESLFIPSLAYAELVSNVVMTAGGDQLHDSDGHLHLQKGCREAVPDGRSRRTEGCHSNSSEIVLWEIEKAGTEQEEGTCGAEKVEQKKLRNATKDTQEDGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MY72</accession>
    <name>A0A151MY72_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0004907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004653">
        <property type="protein sequence ID" value="KYO29501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MY72"/>
    <dbReference type="STRING" id="8496.A0A151MY72"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000212">
        <property type="entry name" value="Immunoglobulin kappa chain variable 12-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001230">
        <property type="entry name" value="Immunoglobulin kappa variable 8-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO29501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="212" mass="22933" checksum="C204263FCF9C32AB" modified="2016-06-08" version="1">MLTQSPESLSVPVGGRVSITCKASTSVGTCLNWYQQKPGQVPKLMIYYASSLQSGVPARFSGTGSGTDFTFTISSVKADDAADHYCQQCAQRQIVVMQSPGSVAVSVGKTITIQSRSSRDIGREMSWYQQNPGQAPKLLVYSDNRYTGNPDRFSPSGSGTDFTPTISGLEAEDAGNYYCQQDYTTPLTVMHPTTQTSLLSEACRVADSDEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYI2</accession>
    <name>A0A151MYI2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NAGK</name>
        <name evidence="6" type="ORF">Y1Q_0004965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03004653">
        <property type="protein sequence ID" value="KYO29570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006257929.1">
        <property type="nucleotide sequence ID" value="XM_006257867.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYI2"/>
    <dbReference type="STRING" id="8496.A0A151MYI2"/>
    <dbReference type="GeneID" id="102567348"/>
    <dbReference type="KEGG" id="amj:102567348"/>
    <dbReference type="CTD" id="55577"/>
    <dbReference type="eggNOG" id="KOG1794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MYI2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd24078">
        <property type="entry name" value="ASKHA_NBD_NAGK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039758">
        <property type="entry name" value="NAGK-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862">
        <property type="entry name" value="BADF TYPE ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862:SF0">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO29570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="343" mass="37090" checksum="991FCE321266E524" modified="2016-06-08" version="1">MAALFGGVEGGGTHSKVVLISEDGKILAETNGPCTNHWLVGSEKCLERINEMVSEAKGKAGADPQVPLRSLGLSLSGGEQKEAIKKMIEELQTRFPQLSENYYITTDAIGAMATATDHGGVVLISGTGSNCKLINPDGTEIGCGGWGHMMGDEGSAYWIAHQAVKIVFDCMDNLEVPPHDVGYVKQAMFDYFQISDRMGLLTHLYRTFEKSKFAGFCQKLAEGAQARDPLCCYIFNKAGEVLARHIVAVLPKIDKSLFLGELGLPIVCVGSVWNSWDMMKDGFVQVLNQARSEQPGSIFSKFSLLKLKHSSALGGASLGAKQIGQALPLDYTANVDIFYTHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYJ0</accession>
    <name>A0A151MYJ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004672">
        <property type="protein sequence ID" value="KYO29489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYJ0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="197" mass="21172" checksum="A59E651657948B91" modified="2016-06-08" version="1">MLPGEYCHLMIIPEIFRVSGAKMCKHKGKELPFTNGVLKSSGKERSQAHLEHWISTTGSPGALLRCAFAERLTLIKRRKESVVVATVFVKLASASGLTLILSHSSNNSNSVTISQIFYFQVETTDLREVSPTTPSIQVLGTSNSGSLGYSGPEAAHGTVATLGSQVAGPGSLPSIARALWMHRLCQRSTQAHTILLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1B1</accession>
    <name>A0A151N1B1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS35 endosomal protein-sorting factor-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0008232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1B1"/>
    <dbReference type="STRING" id="8496.A0A151N1B1"/>
    <dbReference type="KEGG" id="amj:102566276"/>
    <dbReference type="eggNOG" id="KOG3682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1734063at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO30591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="963" mass="109315" checksum="81ED93A65E213C20" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1L0</accession>
    <name>A0A151N1L0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small integral membrane protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SMIM10</name>
        <name evidence="1" type="ORF">Y1Q_0008268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1L0"/>
    <dbReference type="STRING" id="8496.A0A151N1L0"/>
    <dbReference type="GeneID" id="102559400"/>
    <dbReference type="KEGG" id="amj:102559400"/>
    <dbReference type="CTD" id="122526779"/>
    <dbReference type="eggNOG" id="ENOG502S7BN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9619930at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029367">
        <property type="entry name" value="SMIM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34446:SF1">
        <property type="entry name" value="SALIVARY GLAND SPECIFIC PROTEIN SAGSIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34446">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15118">
        <property type="entry name" value="DUF4560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7657" checksum="83618A3558B471D3" modified="2016-06-08" version="1">MAAALSALAARLSQSAAARSYGVFCKGLTRTLLIFFDLAWKLRINFPYLYIVASMMLNVRLQVHIEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1L8</accession>
    <name>A0A151N1L8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Parvalbumin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0008277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the parvalbumin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1L8"/>
    <dbReference type="STRING" id="8496.A0A151N1L8"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16255">
        <property type="entry name" value="EFh_parvalbumin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000060">
        <property type="entry name" value="Parvalbumin, thymic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008080">
        <property type="entry name" value="Parvalbumin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653">
        <property type="entry name" value="PARVALBUMIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11653:SF3">
        <property type="entry name" value="PARVALBUMIN, THYMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608080-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO30648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="156" mass="16872" checksum="0AB2E08C897DA47C" modified="2016-06-08" version="1">MNTYAIPVMSSTVVYISKLSPDEDTQQVLSLQLDCLLLQSRRPQSPAMAITDILSAKDIEAALSSCRAAESFNYKSFFSTVGLTGKSADQIKKVFGILDQDKSGFIEEDELQLFLKNFSSSARALTDAETKAFLAAGDTDGDGKIGVDEFQALVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N264</accession>
    <name>A0A151N264_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pleckstrin-like proteiny domain-containing family G member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PLEKHG2</name>
        <name evidence="2" type="ORF">Y1Q_0004973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004138">
        <property type="protein sequence ID" value="KYO30891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N264"/>
    <dbReference type="STRING" id="8496.A0A151N264"/>
    <dbReference type="eggNOG" id="KOG3518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.70">
        <property type="entry name" value="Interleukin-15/Interleukin-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="458" mass="48792" checksum="F581EE097D2D5C97" modified="2016-06-08" version="1">MGGNQEEKRLWIHYLQRLIVENHPASIPQKAKQVLLENSFQGSPALPWSPASPPRLEEPWSCPRGRRQSAEDPPETATRSPAMPPGPEEMTQTYSAMRAASPGVEGSTLVPVATPVPVATLLPPAAEDPPEIGAACSPLESPGPEEETSSTVHTAPLGTEGGTLVPINPLLPPGLLHPMEEPPAETAVPQDPPGPEEETPLCRAVHPALPGAEGSTPVPLAHPGSPDQGPPLAPRRPSALSRYLAASCISQSLAKRPGGGGTPSPTLPRASYATTVNIQLGGGGRVAGFRTAQGSPHPRMVVCGAGAGLDGDPPTGARGLCTLLLVSLLPCVPGREPPGCREGVRLLHNVTRLLGDANDPKLYTPDDITVCTVENLNCFRTELDVIRWERPEHQGAVNLLRRHLKQLEWRLERLACPRTSARPCRACELHPEQPAPCFLDRLLQLLQRQCRLPPCVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N582</accession>
    <name>A0A151N582_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Nitric oxide synthase 1</fullName>
            <ecNumber evidence="8">1.14.13.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Constitutive NOS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">NC-NOS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">NOS type I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Neuronal NOS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Nitric oxide synthase, brain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Peptidyl-cysteine S-nitrosylase NOS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="ORF">Y1Q_0022825</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:19897"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:19898"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <location evidence="5">Sarcolemma</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NOS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="37">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N582"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043271">
        <property type="term" value="P:negative regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903522">
        <property type="term" value="P:regulation of blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010959">
        <property type="term" value="P:regulation of metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06202">
        <property type="entry name" value="Nitric_oxide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00795">
        <property type="entry name" value="NOS_oxygenase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06708">
        <property type="entry name" value="PDZ_nNOS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.440.10:FF:000001">
        <property type="entry name" value="Endothelial nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000002">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000069">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1230.10:FF:000001">
        <property type="entry name" value="Nitric oxide synthase, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012144">
        <property type="entry name" value="NOS_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF2">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000333">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="15" id="KW-0274">FAD</keyword>
    <keyword evidence="12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0288">FMN</keyword>
    <keyword evidence="11 32" id="KW-0349">Heme</keyword>
    <keyword evidence="20 32" id="KW-0408">Iron</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 32" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0770">Synapse</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PDZ" evidence="34">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="35">
        <location>
            <begin position="767"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="36">
        <location>
            <begin position="1002"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="33">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="32">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00031302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00031374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00032538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00035211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00035474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR000333-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="KYO31745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1441" mass="162580" checksum="B1E2BD11C1D3EBE3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N638</accession>
    <name>A0A151N638_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase RNFT1</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING finger and transmembrane domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RNFT1</name>
        <name evidence="19" type="ORF">Y1Q_0007204</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N638"/>
    <dbReference type="eggNOG" id="KOG4638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044235">
        <property type="entry name" value="RNFT1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNFT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860">
        <property type="entry name" value="UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO32231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="269" mass="31728" checksum="527CE2A93E648FFE" modified="2016-06-08" version="1">MQHIIGISIGIGLLTTFMYANKSIVNQVFLRERCSKLHCAWLLVFLTGSSLLLYYTFYSQSLYYSLIFLNPTVDFMNFWEVLWIVGITDFILKFLFMGFKCFILLVPSFMMSFKSKGYCYMLLEELCQYYRMFVPIPVWFRYLIGYRELDGLLGWSFGVLLGLLYLILKLLSFFGQLRNFRQVLRIFFTRPRYGVTASKRQCSEADDICAICQAEFQKPILLICQHIFCEECISLWFNREKICPLCRTHVKNQLDNLGYDLEIVSAHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7P1</accession>
    <name>A0A151N7P1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0009389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLITRK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7P1"/>
    <dbReference type="STRING" id="8496.A0A151N7P1"/>
    <dbReference type="KEGG" id="amj:102564153"/>
    <dbReference type="eggNOG" id="ENOG502QQXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000001">
        <property type="entry name" value="SLIT and NTRK-like family, member 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773:SF3">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585818" description="LRRCT domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="12">
        <location>
            <begin position="213"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="12">
        <location>
            <begin position="531"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO32806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="837" mass="94432" checksum="A5111CDF0797A85C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N908</accession>
    <name>A0A151N908_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neuron navigator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Pore membrane and/or filament-interacting-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NAV3</name>
        <name evidence="20" type="ORF">Y1Q_0015005</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May be involved in neuronal migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nav/unc-53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N908"/>
    <dbReference type="eggNOG" id="ENOG502QSUE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043194">
        <property type="term" value="C:axon initial segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000409">
        <property type="entry name" value="Neuron navigator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057126">
        <property type="entry name" value="NAV1-like_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF3">
        <property type="entry name" value="NEURON NAVIGATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23092">
        <property type="entry name" value="Ubiquitin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
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                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
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                <person name="Triplett E.W."/>
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                <person name="Venegas-Anaya M."/>
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        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
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                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO34080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBB4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7259" checksum="BC8E1A5E411E5449" modified="2016-06-08" version="1">MLRSRVCLPRQNLTSKSMREAGGEISPATTTLLAVEPPGPKLSPRVCPQGFMHLDLPNGLTADTLTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCE1</accession>
    <name>A0A151NCE1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch-like protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003404">
        <property type="protein sequence ID" value="KYO34486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCE1"/>
    <dbReference type="STRING" id="8496.A0A151NCE1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052392">
        <property type="entry name" value="Kelch-BTB_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375:SF3">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="166" mass="18539" checksum="920386C80FF1006D" modified="2016-06-08" version="1">MDNGGPSNKGGRLLGFSRTGPSHLWNLIFVTGGYFRDGFLWYSVDWVMIYNCWDNSWLEGPEMKKSRNSHCSVGAGLYLYVLGGSTDEGIISHVERLALSDSQWESTSPMVQPVERADAVNVGTRIYVVCGLDENGDVYDGVQRLDMETDIWDVISFSPLPSIYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCW0</accession>
    <name>A0A151NCW0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003364">
        <property type="protein sequence ID" value="KYO34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCW0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="99" mass="11881" checksum="B1FF26B687A3170B" modified="2016-06-08" version="1">MYKHMNLPVEDCITMEVSELQMYCKKMEGEDEEKMAEDTWNTWKRKEWQRLFRNGIPREDDNHDGEEINDDDREEEDDKYNSGEDKNDKEDGDMGVAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDA2</accession>
    <name>A0A151NDA2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosome-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RRBP1</name>
        <name evidence="9" type="ORF">Y1Q_0010525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003332">
        <property type="protein sequence ID" value="KYO34784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDA2"/>
    <dbReference type="STRING" id="8496.A0A151NDA2"/>
    <dbReference type="eggNOG" id="ENOG502QV05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007794">
        <property type="entry name" value="Rib_rcpt_KP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040248">
        <property type="entry name" value="RRBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939">
        <property type="entry name" value="RIBOSOME BINDING PROTEIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939:SF4">
        <property type="entry name" value="RIBOSOME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05104">
        <property type="entry name" value="Rib_recp_KP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ribosome receptor lysine/proline rich" evidence="8">
        <location>
            <begin position="738"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="888"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="202"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="443"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="888"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO34784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="916" mass="103048" checksum="9AEFD7EE9641E905" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG14</accession>
    <name>A0A151NG14_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Amyloid-like protein 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">APLP2-1</name>
        <name evidence="17" type="ORF">Y1Q_0010184</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG14"/>
    <dbReference type="STRING" id="8496.A0A151NG14"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21709">
        <property type="entry name" value="JMTM_APLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22607">
        <property type="entry name" value="Kunitz_ABPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.570.10:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.770:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000003">
        <property type="entry name" value="amyloid-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.770">
        <property type="entry name" value="Amyloid precursor protein, E2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.140">
        <property type="entry name" value="Amyloidogenic glycoprotein, copper-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.570.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036669">
        <property type="entry name" value="Amyloid_Cu-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008155">
        <property type="entry name" value="Amyloid_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011178">
        <property type="entry name" value="Amyloid_glyco_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024329">
        <property type="entry name" value="Amyloid_glyco_E2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008154">
        <property type="entry name" value="Amyloid_glyco_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015849">
        <property type="entry name" value="Amyloid_glyco_heparin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036454">
        <property type="entry name" value="Amyloid_glyco_heparin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019745">
        <property type="entry name" value="Amyloid_glyco_intracell_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019543">
        <property type="entry name" value="APP_amyloid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036176">
        <property type="entry name" value="E2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103">
        <property type="entry name" value="ALZHEIMER'S DISEASE BETA-AMYLOID RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103:SF14">
        <property type="entry name" value="AMYLOID BETA PRECURSOR LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10515">
        <property type="entry name" value="APP_amyloid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12924">
        <property type="entry name" value="APP_Cu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12925">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02177">
        <property type="entry name" value="APP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00203">
        <property type="entry name" value="AMYLOIDA4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00006">
        <property type="entry name" value="A4_EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56491">
        <property type="entry name" value="A heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89811">
        <property type="entry name" value="Amyloid beta a4 protein copper binding domain (domain 2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109843">
        <property type="entry name" value="CAPPD, an extracellular domain of amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51869">
        <property type="entry name" value="APP_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51870">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00320">
        <property type="entry name" value="APP_INTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586029" evidence="13">
        <location>
            <begin position="27"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="E1" evidence="15">
        <location>
            <begin position="41"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="E2" evidence="16">
        <location>
            <begin position="334"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="GFLD subdomain" evidence="10">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="CuBD subdomain" evidence="10">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO35751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="721" mass="81950" checksum="B066147193684B30" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGD7</accession>
    <name>A0A151NGD7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003057">
        <property type="protein sequence ID" value="KYO35872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGD7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="10899" checksum="FAF88F898B81B9F4" modified="2016-06-08" version="1">MAELSVAGQRQGEASRAGPWAPAGREGREAAYPRRARLISEFGHGGLQHGSRPAPMRGGWRHKRSRQVCESPARRRCLMMSLSAPGVSNSRSSSSASGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NH80</accession>
    <name>A0A151NH80_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho GTPase-activating protein 39-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0000159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003011">
        <property type="protein sequence ID" value="KYO36172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NH80"/>
    <dbReference type="STRING" id="8496.A0A151NH80"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000022">
        <property type="entry name" value="Rho GTPase activating protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO36172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="178" mass="20472" checksum="E2B8C567D3D3D227" modified="2016-06-08" version="1">MPQAGFGPPKRTRDLSRPAVVDAEMPSPLKDGRLEWVEIIEPRTRERMYANLITGECVWDPPAGVRIKRTNENQWWELFDPNTSRFYYYNATTQRTVWHRPQNCDIIPLAKLQTLKQNTESPRASTENSPGRSSNVSREGSTSSSLEQELEGSEKPPEQVRPSRQVTQYAPVKEETER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHK5</accession>
    <name>A0A151NHK5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0024068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHK5"/>
    <dbReference type="STRING" id="8496.A0A151NHK5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20272">
        <property type="entry name" value="Complex1_LYR_MIEF1-MP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045300">
        <property type="entry name" value="Complex1_LYR_MIEF1-MP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="90" mass="10784" checksum="5A945F13B65E279A" modified="2016-06-08" version="1">MAAWSRQAVLSLYRTLLRQGRRLRFTDRDFYLATIRREFRKNKQLEQLEDKERQLEKGQAFLHSKLGGCIKSQVRWQALGSARERRMTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NI94</accession>
    <name>A0A151NI94_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sugar phosphate exchanger 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 37 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC37A3</name>
        <name evidence="16" type="ORF">Y1Q_0024229</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014464145.1">
        <property type="nucleotide sequence ID" value="XM_014608659.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014464146.1">
        <property type="nucleotide sequence ID" value="XM_014608660.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NI94"/>
    <dbReference type="STRING" id="8496.A0A151NI94"/>
    <dbReference type="GeneID" id="102563030"/>
    <dbReference type="CTD" id="84255"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NI94"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006855">
        <property type="term" value="P:xenobiotic transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17342">
        <property type="entry name" value="MFS_SLC37A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000028">
        <property type="entry name" value="Sugar phosphate exchanger 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000132">
        <property type="entry name" value="sugar phosphate exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="15">
        <location>
            <begin position="27"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO36504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="501" mass="55283" checksum="D4114BC8E7C9A44F" modified="2016-06-08" version="1">MAMPRSLRRQPGNRALASICTHHHIAVFLLTFFSYSLLHASRKTFSNVKVSISSQWTPTFLNNTAMELQPYELWNSSHLFSTAEEATLFLGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFLFGTVTEWLHFYNKWFYCCLWVLNGLLQSTGWPCVVAVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVLKYGYEYAFLVTTSVQFAGGGVVFFGLITSPKEVGLPELDAEEKNVVEEDANRPLMSSEDVDDYDRNYSIQASDSSIQPKAIGFFQACCLPGVILYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADQLSIWYDVGGIIGGTIQGLISDMLQKRAPVLAISLLLAVGALFGYSRSPDSKPINAVIMAVTGFFIGGPSNMISSAISADLGRQELVRGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFFILMISSTILFISPLVVREIRLLLQERRLRRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIF1</accession>
    <name>A0A151NIF1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Importin-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">IPO8</name>
        <name evidence="10" type="ORF">Y1Q_0024276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019344921.1">
        <property type="nucleotide sequence ID" value="XM_019489376.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIF1"/>
    <dbReference type="STRING" id="8496.A0A151NIF1"/>
    <dbReference type="GeneID" id="106736835"/>
    <dbReference type="KEGG" id="amj:106736835"/>
    <dbReference type="CTD" id="10526"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NIF1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000053">
        <property type="entry name" value="Importin 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF26">
        <property type="entry name" value="IMPORTIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="884"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO36567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1017" mass="117133" checksum="6EEED724EEEBA166" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJL2</accession>
    <name>A0A151NJL2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CENPT-1</name>
        <name evidence="18" type="ORF">Y1Q_0000856</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Identified in a centromeric complex containing histones H2A, H2B, H3 and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts (via N-terminus) with the NDC80 complex. Heterodimer with CENPW; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-T/CNN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002899">
        <property type="protein sequence ID" value="KYO36977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJL2"/>
    <dbReference type="STRING" id="8496.A0A151NJL2"/>
    <dbReference type="GeneID" id="102567576"/>
    <dbReference type="KEGG" id="amj:102567576"/>
    <dbReference type="CTD" id="80152"/>
    <dbReference type="eggNOG" id="ENOG502RZH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028255">
        <property type="entry name" value="CENP-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032373">
        <property type="entry name" value="CENP-T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16171">
        <property type="entry name" value="CENP-T_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere kinetochore component CENP-T N-terminal" evidence="17">
        <location>
            <begin position="49"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="16">
        <location>
            <begin position="670"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="277"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="639"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO36977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="778" mass="86473" checksum="BE95925A81F85394" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJZ6</accession>
    <name>A0A151NJZ6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Bifunctional polynucleotide phosphatase/kinase</fullName>
            <ecNumber evidence="2">2.7.1.78</ecNumber>
            <ecNumber evidence="19">3.1.3.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">DNA 5'-kinase/3'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Polynucleotide kinase-3'-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PNKP</name>
        <name evidence="25" type="ORF">Y1Q_0008406</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14113"/>
            <dbReference type="Rhea" id="RHEA-COMP:13863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138147"/>
            <dbReference type="ChEBI" id="CHEBI:138148"/>
            <dbReference type="EC" id="3.1.3.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13184"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136416"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Monomer. Interacts (via FHA domain) with XRCC4; mainly interacts with XRCC4 phosphorylated by CK2 but is also able to interact at much lower level with unphosphorylated PNKP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the DNA 3' phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.78" evidence="2"/>
    <dbReference type="EC" id="3.1.3.32" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJZ6"/>
    <dbReference type="STRING" id="8496.A0A151NJZ6"/>
    <dbReference type="eggNOG" id="KOG2134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000009">
        <property type="entry name" value="bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041388">
        <property type="entry name" value="FHA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006550">
        <property type="entry name" value="PNKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01663">
        <property type="entry name" value="PNK-3'Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17913">
        <property type="entry name" value="FHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNK FHA" evidence="24">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="175"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00063101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00074686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00078896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF17913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO37124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="628" mass="68764" checksum="B15B11C6F557FFB2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMQ7</accession>
    <name>A0A151NMQ7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein Rab-33A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RAB33A</name>
        <name evidence="4" type="ORF">Y1Q_0007233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMQ7"/>
    <dbReference type="SMR" id="A0A151NMQ7"/>
    <dbReference type="STRING" id="8496.A0A151NMQ7"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO38107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="163" mass="18171" checksum="EE7720250E118282" modified="2016-06-08" version="1">MAQPAPGGGAGQPGGLAALALDASLDQYVQIRIFKIIVIGDSNVGKTCLTFRFCGGTFPDKTEATIGVDFREKTVEIEGEKIKVQVWDTAGQERFRKSMVEHYYRNVHAVVFVYDVTKMTSFTNLKTWIEECNGHAVPPLVPKPRTLKRVKMWSQFSCAWLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NN67</accession>
    <name>A0A151NN67_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">26S proteasome non-ATPase regulatory subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">26S proteasome regulatory subunit p28</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Gankyrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PSMD10</name>
        <name evidence="15" type="ORF">Y1Q_0015542</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of transient complex containing PSMD10, PSMC4, PSMC5 and PAAF1 formed during the assembly of the 26S proteasome. Stays associated throughout the assembly of the PA700/19S RC and is released upon association with the 20S core. Interacts with PSMC4. Interacts with RB1. Interacts with CDK4. Interacts with MDM2. Interacts with RELA. Associates with a CDK4:CCND2 serine/threonine kinase complex. Interacts with ARHGDIA and increases the interaction between ARHGDIA and RHOA, hence promotes ARHGDIA inactivation of RHOA and ROCK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006262728.2">
        <property type="nucleotide sequence ID" value="XM_006262666.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NN67"/>
    <dbReference type="STRING" id="8496.A0A151NN67"/>
    <dbReference type="GeneID" id="102576751"/>
    <dbReference type="KEGG" id="amj:102576751"/>
    <dbReference type="CTD" id="5716"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000149">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO38271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="226" mass="24286" checksum="04316E38586A403C" modified="2016-06-08" version="1">MEGSVSNVELCNLAYAGQLDELRARLLQDRGLAARTDQDRRTALHWACSAGHADIANFLLNLGAPVGPPDDAGWTPLHIAASAGRDEIVKVLIGRGAQVNVANQNGCTPLHYAASKNREEIAVMLLENGADPDATDHFESTPLHRAAAKGNLKMIQILLRYNASVNMQDSEGNTPLHLACDEERADEAKLLVSRGSSIYIENKEEMTPLKVAKGGLGAILKKMVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNN3</accession>
    <name>A0A151NNN3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine-rich hydrophobic domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CHIC1</name>
        <name evidence="6" type="ORF">Y1Q_0015582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263716.1">
        <property type="nucleotide sequence ID" value="XM_006263654.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNN3"/>
    <dbReference type="GeneID" id="102559470"/>
    <dbReference type="KEGG" id="amj:102559470"/>
    <dbReference type="CTD" id="53344"/>
    <dbReference type="eggNOG" id="KOG4101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67682at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NNN3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039735">
        <property type="entry name" value="CHIC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC DOMAIN PROTEIN BRAIN X-LINKED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005:SF2">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="5">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO38320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="179" mass="20612" checksum="7D939D384E06B5C5" modified="2016-06-08" version="1">MSVLLPNMADFDTIYELEEEEEPEPEPVVRSQELPRPRDAPDPVAVRGAGHITVFGLSNKFDTEFPSVLTGKVAPEEFKTSISRVNACLKKNLPVNVKWLLCGCLCCCCTLGCSLWPVICLNKRTRRSIQKLLEWENNRLYHKLGLHWKLSKRKCETSNMMEYVILIEFLPKYPIFRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPR2</accession>
    <name>A0A151NPR2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPR2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="12175" checksum="F1B21E01C265646E" modified="2016-06-08" version="1">MPQSLCHGDNSRHGWGKKNTWLWDLPDEPTAVHVRGNQSSSSGFLLGDAEEGAGMLMDALKSRPGKVMAQVAEPGVTELSARQTAAVNYARLFQLSGRFTPHEKALEKQGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQ21</accession>
    <name>A0A151NQ21_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tetraspanin-33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TSPAN33</name>
        <name evidence="16" type="ORF">Y1Q_0023527</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQ21"/>
    <dbReference type="STRING" id="8496.A0A151NQ21"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046931">
        <property type="term" value="P:pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03158">
        <property type="entry name" value="penumbra_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000007">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF154">
        <property type="entry name" value="TETRASPANIN-33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO38874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="365" mass="40003" checksum="A2E56CB604169B28" modified="2016-06-08" version="1">MVALGSASMKSCCKMISMVMVAVGVYARLMKHAEAAMACLAVDPAILLIVVGVLMFLITFCGCIGSLRENICLLQTFSVCLTIVFLLQLAAGVLGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKEFSCCGGISYKDWSQNMYFNCTADNPSRERCSVPYSCCLRTADEAVINTMCGQGMQAMNYLEASKFIYTNGCIDKLVNWIHSNLFLLGGIALGLAIPQLVGILLSQILINQIKDQVKLQLYNQQHRADPWSSPPRARLMESPAVSVACSMQGSDGATIQSSHLGLHSLNDETCSQLGWRQGEAKRLVQHHAASGPLNLDQTQSPRPGPWALTRLDLPDHRSPAVESWQTDPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRN9</accession>
    <name>A0A151NRN9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002318">
        <property type="protein sequence ID" value="KYO39299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRN9"/>
    <dbReference type="STRING" id="8496.A0A151NRN9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="83" mass="9292" checksum="74DFD05C00E7793B" modified="2016-06-08" version="1">MPRTAPILCPPPPRGAFSEVVLAEERTTRKLVAIKCITKKALEGKETSIENEIDVLHKIQHPNIVALDDIYESGSHLYLIMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NS84</accession>
    <name>A0A151NS84_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">26S proteasome regulatory subunit p27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PSMD9-1</name>
        <name evidence="10" type="ORF">Y1Q_0018760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NS84"/>
    <dbReference type="STRING" id="8496.A0A151NS84"/>
    <dbReference type="GeneID" id="102572061"/>
    <dbReference type="KEGG" id="amj:102572061"/>
    <dbReference type="CTD" id="5715"/>
    <dbReference type="eggNOG" id="KOG3129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO39731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="205" mass="22593" checksum="C3A8FA62940F56A8" modified="2016-06-08" version="1">MAEPAVSAHDVQCLVRRKDEIEAQIRACYELLEDQKGVGMSEPLVDAEGYPRADIDLYQVRTARHNIICLQNDHKAVMRQVEEALHQLHAREKEKRARDEAEAQAEAVSQNQSLPQPFARVNAVTPGSPASLAGLQVDDEIVEFGSVKAHNFQTLQNIATVVQHSEGKPLSVSVIRGGEKVHLGLTPKRWAGKGLLGCNIVPLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NT28</accession>
    <name>A0A151NT28_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hemojuvelin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Hemojuvelin BMP coreceptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RGM domain family member C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">HFE2</name>
        <name evidence="19" type="ORF">Y1Q_0004453</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with BMP2 and BMP4. Interacts with BMP6. Interacts with BMPR1B. Interacts with TMPRSS6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the repulsive guidance molecule (RGM) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002142">
        <property type="protein sequence ID" value="KYO39948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NT28"/>
    <dbReference type="STRING" id="8496.A0A151NT28"/>
    <dbReference type="eggNOG" id="ENOG502QWAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.10:FF:000003">
        <property type="entry name" value="hemojuvelin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040287">
        <property type="entry name" value="RGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009496">
        <property type="entry name" value="RGM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010536">
        <property type="entry name" value="RGM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428:SF3">
        <property type="entry name" value="HEMOJUVELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428">
        <property type="entry name" value="RGM DOMAIN FAMILY MEMBER DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06534">
        <property type="entry name" value="RGM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06535">
        <property type="entry name" value="RGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Repulsive guidance molecule N-terminal" evidence="18">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule C-terminal" evidence="17">
        <location>
            <begin position="152"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO39948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="413" mass="45928" checksum="9A5E438F4A721161" modified="2016-06-08" version="1">MIAVGSLKEQVPTLNDRGELVRGARRNSRALFLLLFCRYVSSQCKILRCNSEYVAATLNLRGSNKNAAYCNALRSYSHCTRKTARTCRGDLAYHSAVHGIEDLMIQNNCSKEGPTSPPRPRLPAPNHQGFESLDICNYEKNFFHKNGRPPAYQHCAAFGDPHIRTFHDDFHTCRVEGSWPLLDNNYLFVQATSYPVAKGSNATVTSKLTIIFKNMKECIDQKVYQAEIDNLPAAFEDGSVNGGERPGGSSLTIQERLPGQHVEIRAVYIGTTIAVRQAGRQLSFSIRTAEQVARSFTEEQDLQLCVSGCPPSQRLSRSECRRGSIAVEMARVLCKEKLPVEDVYFQSCVFDVVTSGDINFTLAAHGALEDARVFHPDAEKLHIFQTGAGCHHLSLPFLFLSITSSLLAIQLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NT82</accession>
    <name>A0A151NT82_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Olfactory receptor 6M1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0020163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002087">
        <property type="protein sequence ID" value="KYO40091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NT82"/>
    <dbReference type="eggNOG" id="ENOG502QVH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15912">
        <property type="entry name" value="7tmA_OR6C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000010">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047132">
        <property type="entry name" value="Olfact_rcpt_6C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454:SF155">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26454">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO40091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="260" mass="29124" checksum="615472EA5E6F1F72" modified="2016-06-08" version="1">MYYFLSNLSFIEILMTSSLVPKMLANFLSEKKAISFTGCFSQLFFYFFMGTTEFILFAIMSYDRYVAICNPLRYSTIMTGKICIQLVIGSWAGGLFMILSSLILKAQLPYCGPNVINHYFCDSAPLLHLACADVQLIEFIDFIVSLVLLLGSLSLTVVSYAYIISTILKIPSAQGRQKAFATCASHFTVVSLGFGITMFVYVRPSQSDSMKFNKILSVLSSIVTPLLNPFIFSLRNEQMKEALKDAVKKYLLITQWAGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUB5</accession>
    <name>A0A151NUB5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001930">
        <property type="protein sequence ID" value="KYO40354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUB5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12057" checksum="FC54DD9169B99FAB" modified="2016-06-08" version="1">MLQTDFTLVYASSQLEKGKMFSDYHIRNKCTRVMITQLPREEDKMPSSMKETCNFHTYSMTCIQNWTVDSSWTGRVYLRGNQIDFEHEGPSTSVVRMIFFPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NV83</accession>
    <name>A0A151NV83_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Thioredoxin-dependent peroxide reductase, mitochondrial</fullName>
            <ecNumber evidence="4">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Thioredoxin-dependent peroxiredoxin 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PRDX3-1</name>
        <name evidence="22" type="ORF">Y1Q_0009526</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer. Interacts with NEK6. Interacts with LRRK2. Interacts with MAP3K13. Interacts with RPS6KC1 (via PX domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NV83"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="21">
        <location>
            <begin position="77"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO40489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="385" mass="42972" checksum="E6A02B5E947551A5" modified="2016-06-08" version="1">MDVRGTVLKALLSFARSRTSSDGEELKRGTVTLIRLAGVPGRAGSLGALRRRXXXPGAEPLPLPRRPFSTSCPKFVPAVTQHAPYFKGTAVLNGEFKEMSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFRDVNCEVVAVSVDSHFCHLAWINTPRKSGGLGHMNIPLLSDLTKQISRDYGVLLEGPGLALRGLFIIDPNGIIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPESPTIKPTPEASKEYFEKSERCSRDRRSCWRPGKPSRCPQWLQQWQQQPRLEGVMAAMNVSSVRKTEMDKGIEVMDKNGEVVGVSWKAGDKLPTSALNEAKVPTVKSESLYNTKSVPEEVNPGHYMRQRMWKDNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVM3</accession>
    <name>A0A151NVM3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho GTPase-activating protein 44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Rho-type GTPase-activating protein RICH2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RhoGAP interacting with CIP4 homologs protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ARHGAP17</name>
        <name evidence="18" type="ORF">Y1Q_0013383</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with BST2 (via cytoplasmic domain). Interacts (probably via PDZ-binding motif) with SHANK3 (via PDZ domain); the interaction takes place in dendritic spines and promotes GRIA1 exocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Presynapse</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001857">
        <property type="protein sequence ID" value="KYO40814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVM3"/>
    <dbReference type="STRING" id="8496.A0A151NVM3"/>
    <dbReference type="eggNOG" id="KOG4270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031256">
        <property type="term" value="C:leading edge membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098886">
        <property type="term" value="P:modification of dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035021">
        <property type="term" value="P:negative regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061001">
        <property type="term" value="P:regulation of dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07619">
        <property type="entry name" value="BAR_Rich2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000018">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF13">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="BAR" evidence="17">
        <location>
            <begin position="14"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="16">
        <location>
            <begin position="282"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="555"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="674"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO40814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="829" mass="92240" checksum="55383EB7433153FA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVP0</accession>
    <name>A0A151NVP0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Beta-1,4-galactosyltransferase 7</fullName>
            <ecNumber evidence="17">2.4.1.133</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">UDP-galactose:beta-xylose beta-1,4-galactosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">XGPT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">XGalT-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Xylosylprotein 4-beta-galactosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Xylosylprotein beta-1,4-galactosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">B4GALT7</name>
        <name evidence="29" type="ORF">Y1Q_0016920</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="Rhea" id="RHEA-COMP:12570"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="ChEBI" id="CHEBI:132088"/>
            <dbReference type="EC" id="2.4.1.133"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.133" evidence="17"/>
    <dbReference type="EMBL" id="AKHW03001838">
        <property type="protein sequence ID" value="KYO40858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVP0"/>
    <dbReference type="STRING" id="8496.A0A151NVP0"/>
    <dbReference type="eggNOG" id="KOG3917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NVP0"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046525">
        <property type="term" value="F:xylosylprotein 4-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000062">
        <property type="entry name" value="beta-1,4-galactosyltransferase 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF30">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="28">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="27">
        <location>
            <begin position="68"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00082986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00083101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KYO40858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="213" mass="24562" checksum="279BD226C2C9D657" modified="2016-06-08" version="1">MHRFLSAQRVRHRILVLNQADRFRFNRASLINVGFLESGNDTDYIAMHDVDLLPLNEQLDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLTKQHYEMCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFQHLHDPAWRKRDQKRIAAQKQEQFKVDRDGGLNNVRYRIASRTALSVGGAPCTVLNILLDCDTSLTPWCTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW93</accession>
    <name>A0A151NW93_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Deleted in malignant brain tumors 1 protein isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DMBT1</name>
        <name evidence="17" type="ORF">Y1Q_0018830</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001874">
        <property type="protein sequence ID" value="KYO40695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NW93"/>
    <dbReference type="STRING" id="8496.A0A151NW93"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000012">
        <property type="entry name" value="CD163 molecule like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000003">
        <property type="entry name" value="Deleted in malignant brain tumors 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000002">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000004">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF29">
        <property type="entry name" value="OLFACTORY RECEPTOR 292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586444" evidence="15">
        <location>
            <begin position="25"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="238"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="346"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="451"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="556"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="682"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="914"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="158"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="171"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="276"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="384"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="476"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="489"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="580"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="707"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="720"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO40695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="989" mass="107127" checksum="ED2B80C1AB2ED91E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWB8</accession>
    <name>A0A151NWB8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLN3</name>
        <name evidence="9" type="ORF">Y1Q_0019595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001719">
        <property type="protein sequence ID" value="KYO41054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWB8"/>
    <dbReference type="STRING" id="8496.A0A151NWB8"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO41054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="460" mass="48662" checksum="A729D6DAA40FD593" modified="2016-06-08" version="1">MRALGSPCSLAQPPKHPGSSASTPAGLKGPAPMGSDVAGGTWQPLPPSDDEEPSPPPATPDPASWRNGIAFWILGLCNNFAYVVMLSAAHDVLRRHQGPPNGTQPGPLEPLSPNGSSRYDCNAMSTGAVLLADILPTLVIKVSAPFYIHLLPYGLRVGICVLSAWGSFLLVAVAPSVALSLAGVVLASVSSGLGEITFLALTAFYPSGPVSWWSSGTGAAGLLGAVSYLGLTQAGLSPPQTLLAMMGVPLVLLLSYWCLLLPPTPETPSPTRQPLLEGGPPKPEPGPAALSLADKGRIMKGLIRHLLPLGLVYFAEYFINQGLFELLYFPRSRLTHPQQYRWYQLLYQLGVFISRSSLRCVQLRATWVLALLQCVNLVVLTAAVAFRFLPGIAVAFVVVLYEGLLGGAAYVNTFHNIALEVPARREQEFALGAACMADTLGISLAGAAALPAHDYFCRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZY3</accession>
    <name>A0A151NZY3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 27">Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN</fullName>
            <ecNumber evidence="6 27">3.1.3.16</ecNumber>
            <ecNumber evidence="5 27">3.1.3.48</ecNumber>
            <ecNumber evidence="4 27">3.1.3.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Phosphatase and tensin homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">PTEN</name>
        <name evidence="33" type="ORF">Y1Q_0022221</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="27">Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83420"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:43561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83416"/>
            <dbReference type="ChEBI" id="CHEBI:83419"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:43553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57627"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:77144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77155"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57895"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:77156"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:10685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:25018"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Nucleus</location>
            <location evidence="27">PML body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 27">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6 27"/>
    <dbReference type="EC" id="3.1.3.48" evidence="5 27"/>
    <dbReference type="EC" id="3.1.3.67" evidence="4 27"/>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014463305.1">
        <property type="nucleotide sequence ID" value="XM_014607819.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZY3"/>
    <dbReference type="STRING" id="8496.A0A151NZY3"/>
    <dbReference type="GeneID" id="102558284"/>
    <dbReference type="KEGG" id="amj:102558284"/>
    <dbReference type="CTD" id="5728"/>
    <dbReference type="eggNOG" id="KOG2283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030351">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051717">
        <property type="term" value="F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051800">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010648">
        <property type="term" value="P:negative regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051129">
        <property type="term" value="P:negative regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023057">
        <property type="term" value="P:negative regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000003">
        <property type="entry name" value="Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000029">
        <property type="entry name" value="Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017361">
        <property type="entry name" value="Bifunc_PIno_P3_Pase/Pase_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038025">
        <property type="entry name" value="PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 27" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 27" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 27" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15 27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12 27" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="31">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="30">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="32">
        <location>
            <begin position="190"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="29">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="28">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRNR" id="PIRNR038025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR038025-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="KYO42368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="403" mass="47208" checksum="8CA7C8C4B72C50C2" modified="2016-06-08" version="1">MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVYQLKVKIFTSPSGPSRREDKYMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIGLDENLDKVENGSLVGDQELDGIFSTERSDNDKEYLILTLTKNDLDKANKDKANRYFSPNFKVKLFFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P135</accession>
    <name>A0A151P135_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aromatic-L-amino-acid decarboxylase</fullName>
            <ecNumber evidence="13">4.1.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DOPA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">FIGNL1</name>
        <name evidence="21" type="ORF">Y1Q_0016168</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.28" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03001351">
        <property type="protein sequence ID" value="KYO42774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P135"/>
    <dbReference type="STRING" id="8496.A0A151P135"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042423">
        <property type="term" value="P:catecholamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042427">
        <property type="term" value="P:serotonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF167">
        <property type="entry name" value="AROMATIC-L-AMINO-ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="18">
        <location>
            <begin position="923"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="20">
        <location>
            <begin position="1003"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Spastin/Vps4 C-terminal" evidence="19">
        <location>
            <begin position="1048"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="726"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="800"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF09336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO42774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119985" checksum="DA03B3116CA5665A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1Y1</accession>
    <name>A0A151P1Y1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001328">
        <property type="protein sequence ID" value="KYO42910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1Y1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9440" checksum="548F216493D5EA2B" modified="2016-06-08" version="1">MSEDRVRAFWLGPRGRRLLSGSSHPFNGQHPGHRINKGASRRSQPGETRGTSCSPPGTGSQGPCLEEKLMNKAQPWQEDALHLPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P266</accession>
    <name>A0A151P266_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LanC-like protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Testis-specific adriamycin sensitivity protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LANCL2</name>
        <name evidence="18" type="ORF">Y1Q_0017494</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LanC-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P266"/>
    <dbReference type="STRING" id="8496.A0A151P266"/>
    <dbReference type="GeneID" id="102568422"/>
    <dbReference type="KEGG" id="amj:102568422"/>
    <dbReference type="CTD" id="55915"/>
    <dbReference type="eggNOG" id="KOG2787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000022">
        <property type="entry name" value="LanC like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF11">
        <property type="entry name" value="LANC-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="459" mass="51951" checksum="05866FB34AB426E3" modified="2016-06-08" version="1">MGEGMSKRLKLQLGGEADMEERAFANPYPDYQPHGAAAAAAPASSAADTQRDPAPCPKEEESLPFDADGQISYQFTRQIQTKIKDLLQQMEEGLKTADPHDCSTYTGWTGIALLYLQLYRVTTDQTYLQRSLDYVKRILRNLNGRRVTFLCGDAGPLAVGAAVYHKLKNDSESKECVTKLLQLQRTVVSTDSELPDELLYGRAGYLYALLYLNMEIGPDTVPQSVIKEVVDVIIESGKNFSKEERKTDRCPLLYQWHRKQYIGAAHGVAGIYYMLMQPVANVDQDTLTELVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLMQAYKTFKEDKYLKDAMECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYNLTRDKKYFYRACKFAEWCLEYGAHGCRIPDRPYSLFEGMAGAIHFLSDVLVPETSWFPAFELGPQKRENKVEQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2I4</accession>
    <name>A0A151P2I4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2I4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO43150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="254" mass="28455" checksum="BE1405EDAD39CB0F" modified="2016-06-08" version="1">MHLMARNSYQRQESSGPPVPGWTFVPLDLPPLDTEVEQSSSDIRIGGGRRTCCSLGRSQHTLEKSRNHGKDSEGLKIPGSPDPSQQARAANPRNTAQKPADHTNCIQGPSQPFLPLPPHCTGQGQGADVWVWEWQPEMKPKELELADMDKSLVQLQGIHKLENVELWCASHKLLNNDGIMTSRQLVYVLMSYDVPKSTKRSHIGKDVESPLRKILRFKKELFRGPCENIASDLSFIVGLSCRGTILFICKEYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3D0</accession>
    <name>A0A151P3D0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0013495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3D0"/>
    <dbReference type="STRING" id="8496.A0A151P3D0"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="327"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO43429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="491" mass="55045" checksum="C1F637E9AB6907B5" modified="2016-06-08" version="1">MEEVPGDQIEIPKTEEDAGQPGPSPAAPEDGGSGTTVPEDTPPGPPASEDIVPSSAGHARQTAPLHSSEDPPAYLPASRRMSKFRRSVSGVQSLQETIKEKQARYRDARESRKMKVDASYKYIFEVLGDRLSLDVTTVEEMILDGPSLAAFDNFFAKGGNRTLKFLYQEGDAPGVECGRTIPGVVKGTKIMRLYVDTTPDKFKGLCLFFTRYKNDIPVNAKTMHEEIYFCTLDATEGLLLGVRNMLSKIFLPAILATNNWGALNQTKQGTYEKQNFTETINRYLSFLDGATISIKGTVELKKVDSVDFSKLQSFEEVTAAAANPDTVHELEDVLMIWYKQIEQVLIESEQMRKEADDSGPLTELEHWKRMSAKFNFIIEQIKGPSCKCVINVLNIAHSKQLKIWRELDARITDTANESKDNVRYLYTLEKVCQPLYNYDLVSMAHGIQNLINAIRMIHSVSRYYNTSERMTSLFIKMQRSLAGILGGLFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3H3</accession>
    <name>A0A151P3H3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB/POZ domain-containing protein KCTD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">KCTD3</name>
        <name evidence="13" type="ORF">Y1Q_0013617</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with HCN3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KCTD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260428.1">
        <property type="nucleotide sequence ID" value="XM_006260366.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3H3"/>
    <dbReference type="STRING" id="8496.A0A151P3H3"/>
    <dbReference type="GeneID" id="102576589"/>
    <dbReference type="KEGG" id="amj:102576589"/>
    <dbReference type="CTD" id="51133"/>
    <dbReference type="eggNOG" id="KOG2714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P3H3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18393">
        <property type="entry name" value="BTB_POZ_SHKBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000205">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000038">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047876">
        <property type="entry name" value="SHKBP1/KCTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047825">
        <property type="entry name" value="SHKBP1_KCTD3_BTB_POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859">
        <property type="entry name" value="SETA BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="684"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="695"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO43602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="814" mass="88681" checksum="88B5E14261234EA5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4X3</accession>
    <name>A0A151P4X3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 106C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMEM106C</name>
        <name evidence="10" type="ORF">Y1Q_0009036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000895">
        <property type="protein sequence ID" value="KYO44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4X3"/>
    <dbReference type="STRING" id="8496.A0A151P4X3"/>
    <dbReference type="eggNOG" id="ENOG502QQ43">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009790">
        <property type="entry name" value="TMEM106"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048509">
        <property type="entry name" value="TMEM106_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048511">
        <property type="entry name" value="TMEM106_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28556:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 106C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07092">
        <property type="entry name" value="TMEM106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21002">
        <property type="entry name" value="TMEM106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 106 C-terminal" evidence="8">
        <location>
            <begin position="125"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="289" mass="32387" checksum="B5CDA650D715CBD2" modified="2016-06-08" version="1">MRAAEGSNTGHRGGGQKERGRWLLQDMSVARRQRWEEEDDDILCSRDREEDIAKFPYVEFTGRDSITCPTCQGTGCIPTEQVNELVALIPYSDQRLRPQRTKLYVLLSVLLCLLISGLVVFFLFPHSVLVEDDGIKVVQVWFDKKNSIVILAIMATLKIRNSNFYSVAITSLTSQVQYMNTVVGTQQISNVTHIQARSDQLVNFTVKAEMGGPFSYVYFFCTLEKVKVHNIAIFMRTSVKISYIGHLTQSSLETYHYVDCGANSTAVQDSSRMPTSSSIGGTTKAKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5P1</accession>
    <name>A0A151P5P1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Tumor necrosis factor receptor superfamily member 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Low affinity neurotrophin receptor p75NTR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Low-affinity nerve growth factor receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Low-affinity nerve growth factor receptor p75NGFR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Low-affinity nerve growth factor receptor p75NGR</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">NGFR</name>
        <name evidence="34" type="ORF">Y1Q_0012124</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5P1"/>
    <dbReference type="STRING" id="8496.A0A151P5P1"/>
    <dbReference type="eggNOG" id="ENOG502QWPN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005035">
        <property type="term" value="F:death receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048406">
        <property type="term" value="F:nerve growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08311">
        <property type="entry name" value="Death_p75NR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13416">
        <property type="entry name" value="TNFRSF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000034">
        <property type="entry name" value="tumor necrosis factor receptor superfamily member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000012">
        <property type="entry name" value="tumor necrosis factor receptor superfamily member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000013">
        <property type="entry name" value="Tumor necrosis factor receptor superfamily member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000027">
        <property type="entry name" value="tumor necrosis factor receptor superfamily member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052302">
        <property type="entry name" value="Neurotrophin_rcpt-DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041448">
        <property type="entry name" value="TNFR16_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022325">
        <property type="entry name" value="TNFR_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034046">
        <property type="entry name" value="TNFRSF16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46605">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46605:SF3">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18422">
        <property type="entry name" value="TNFR_16_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01966">
        <property type="entry name" value="TNFACTORR16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="18" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14" id="KW-0221">Differentiation</keyword>
    <keyword evidence="20 29" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21 34" id="KW-0675">Receptor</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 31" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="33">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="29">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="29">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="33">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="33">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="29">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="32">
        <location>
            <begin position="344"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="282"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00072356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00082302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00082477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="KYO44364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="427" mass="46201" checksum="D4983DF08423B97A" modified="2016-06-08" version="1">MKFPAAQGADILANHGADYWTYLPEGPAWGAKEKCSTELYTLSGECCKACNLGEGVVQPCGANQTVCEPCLDSVTYSDVVSATEACKPCTQCVGLQSMSAPCVESDDAVCRCAYGYYQDEESGKCKECKICEVGFGLMFPCGDMQDTICEECPEGTFSDEANHVDPCLPCTICEENEVLVKECTPVSDAECRDLHPRWSPRTPTLMGSESPMSFTKDPYDTEGIVSTLAGTVTTIMGSSQPVVSRGTADNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQAANNRPVNQTPSPEGEKLHSDSGISVDSQSLHDQQPQTQTTQGQAVKGDGNLYTSLPPNKQEEVEKLLNSSTEDTWRHLAGELGYKEDHIDSFTQEECPVRALLADWASKDSATVDALYSALRKIQRGDIVESLYSESTATSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P643</accession>
    <name>A0A151P643_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000732">
        <property type="protein sequence ID" value="KYO44528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P643"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7225" checksum="627BCDEC09396629" modified="2016-06-08" version="1">MSVLDTWAWAAACSGPSSLCCHSRAPWPGDIAVTDGSSQRAPSHGSSSWIKELGWAWVLCVSLVPQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7K2</accession>
    <name>A0A151P7K2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0007362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7K2"/>
    <dbReference type="STRING" id="8496.A0A151P7K2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <sequence length="894" mass="96475" checksum="1FDCBBCA21084CCC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P884</accession>
    <name>A0A151P884_ALLMI</name>
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        <submittedName>
            <fullName evidence="15">Transient receptor potential cation channel, subfamily N, member 1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TRPN1</name>
        <name evidence="15" type="ORF">Y1Q_0014703</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="InterPro"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1624" mass="176963" checksum="EDB2923993E964EE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8B4</accession>
    <name>A0A151P8B4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor MafA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MAFA</name>
        <name evidence="9" type="ORF">Y1Q_0014728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006262735.1">
        <property type="nucleotide sequence ID" value="XM_006262673.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8B4"/>
    <dbReference type="STRING" id="8496.A0A151P8B4"/>
    <dbReference type="GeneID" id="102558762"/>
    <dbReference type="KEGG" id="amj:102558762"/>
    <dbReference type="CTD" id="389692"/>
    <dbReference type="eggNOG" id="KOG4196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5974330at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000016">
        <property type="entry name" value="MAF bZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013592">
        <property type="entry name" value="Maf_TF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF30">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08383">
        <property type="entry name" value="Maf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="203"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO45288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="290" mass="32655" checksum="3BDE0F27172537D5" modified="2016-06-08" version="1">MASELAMSAELPTSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPISTPCSSVPSSPSFCAPSPGGQAGVAPGGGGAAANKPQLEDLYWMSNYQHHLNPEALNLTPEDAVEALIGAPHHHHHHHHHQPGYEGFRAQAFGAEEMPPSGHHHHAHHHHHGHHLRLEDRFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRYKRVQQRHILENEKCQLQGQVEQLKQEIARLAKERDLYKEKYEKLAGRAFPREPSPAAAPGKTSADFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PB33</accession>
    <name>A0A151PB33_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PB33"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="191" mass="21174" checksum="334308858B859A38" modified="2016-06-08" version="1">MLTWASSPPPQWMIDKESRVTSYSSLEKVLQGDTKILDRSLVRRIIHLASKDMRETQKSKNHSSQDAEEEQSIQATCVEILENLDVSISGMSQQVVTILAFSAKGHLDLTLSTLEDSGAAMSKVQVSGIVDHLQLICDPVIEEQKLLKPVFHLLQQQARDSNNLVQQMAARGLGSTVYGAPKQLKKHQNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBA3</accession>
    <name>A0A151PBA3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MARCH1</name>
        <name evidence="24" type="ORF">Y1Q_0021780</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBA3"/>
    <dbReference type="STRING" id="8496.A0A151PBA3"/>
    <dbReference type="GeneID" id="102575669"/>
    <dbReference type="KEGG" id="amj:102575669"/>
    <dbReference type="CTD" id="55016"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PBA3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16806">
        <property type="entry name" value="RING_CH-C4HC3_MARCH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000043">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase march8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="23">
        <location>
            <begin position="69"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO46244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="287" mass="32225" checksum="067A975C2F787C88" modified="2016-06-08" version="1">MLGWCQAIARNPHRLPNSTRTPEVSGDASHNSTLNDKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDDESPLITPCRCTGTLRFVHQACLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIVCSVTFHIIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEEKNSSCIQNSEIKDAVVVPVSQTGTNSQPSAEEMTSEVMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDC8</accession>
    <name>A0A151PDC8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Ras-related protein Rab-23</fullName>
            <ecNumber evidence="7">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">RAB23</name>
        <name evidence="29" type="ORF">Y1Q_0014027</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="26">Interacts with SUFU.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Phagosome membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03000483">
        <property type="protein sequence ID" value="KYO47117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006277247.1">
        <property type="nucleotide sequence ID" value="XM_006277185.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059586668.1">
        <property type="nucleotide sequence ID" value="XM_059730685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDC8"/>
    <dbReference type="STRING" id="8496.A0A151PDC8"/>
    <dbReference type="GeneID" id="102557830"/>
    <dbReference type="KEGG" id="amj:102557830"/>
    <dbReference type="CTD" id="51715"/>
    <dbReference type="eggNOG" id="KOG4252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PDC8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04106">
        <property type="entry name" value="Rab23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000669">
        <property type="entry name" value="Ras-related protein Rab-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034114">
        <property type="entry name" value="Rab23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="24" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0488">Methylation</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00062634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00067823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KYO47117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="236" mass="26625" checksum="CBA65CD8B716034D" modified="2016-06-08" version="1">MLEEDMEVAIKVVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAIPTWKEKVVTEVGDIPTVLVQNKIDLLDDSCIKNEEAEALAKKLKLRFYRASVKEDLNVTEVFKYLAEKYLQRLKQQTTEDPELVHTSSNKIGVFNTAGSHSGQNTSTLNGGDVINLRPNKQRTKKNRSPFSNCSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE99</accession>
    <name>A0A151PE99_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="22">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">INSR</name>
        <name evidence="28" type="ORF">Y1Q_0012434</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="22"/>
    <dbReference type="EMBL" id="AKHW03000456">
        <property type="protein sequence ID" value="KYO47299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PE99"/>
    <dbReference type="GeneID" id="102576524"/>
    <dbReference type="CTD" id="3645"/>
    <dbReference type="eggNOG" id="KOG4258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05032">
        <property type="entry name" value="PTKc_InsR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000050">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000014">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000087">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000108">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000026">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000002">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016246">
        <property type="entry name" value="Tyr_kinase_insulin-like_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF338">
        <property type="entry name" value="INSULIN RECEPTOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000620">
        <property type="entry name" value="Insulin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 22" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14 22 28" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 25" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 22 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586942" description="Tyrosine-protein kinase receptor" evidence="25">
        <location>
            <begin position="30"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="954"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="491"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="851"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="1020"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="759"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1030"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 21">
        <location>
            <position position="1054"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1101"/>
            <end position="1107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1160"/>
            <end position="1161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000620-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000620-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KYO47299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1353" mass="152002" checksum="6E3E73A1CD217B15" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEQ9</accession>
    <name>A0A151PEQ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-tubulin complex component 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TUBGCP6</name>
        <name evidence="14" type="ORF">Y1Q_0019629</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG2000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000004">
        <property type="entry name" value="gamma-tubulin complex component 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045818">
        <property type="entry name" value="GCP6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19340">
        <property type="entry name" value="GCP6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-tubulin complex component 6 N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="12">
        <location>
            <begin position="359"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="11">
        <location>
            <begin position="1299"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="890"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1080"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="711"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1108"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO47500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1603" mass="182055" checksum="F41C250DE7998EA6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PER9</accession>
    <name>A0A151PER9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PER9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11642" checksum="36E570854B764058" modified="2016-06-08" version="1">MRKPPKLTIPAHGGNPRCPPLPHTTWEALHQPLKVPRPLQERNIHKHMANLKYMNRPSGFTRTTHGLKFRVLKNQQGSAKRREEEAAAMILNHRFLRQGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LY30</accession>
    <name>A0A151LY30_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testicular acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ACPT</name>
        <name evidence="2" type="ORF">Y1Q_0007598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007081">
        <property type="protein sequence ID" value="KYO17162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LY30"/>
    <dbReference type="STRING" id="8496.A0A151LY30"/>
    <dbReference type="eggNOG" id="KOG3720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120154">
        <property type="term" value="P:negative regulation of ERBB4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF145">
        <property type="entry name" value="TESTICULAR ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO17162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="352" mass="39379" checksum="137160CCE5503EBD" modified="2016-06-08" version="1">MDTYPSDPHKEGPWPQGFQQLTQVGVEQQRELGQFLRQRYEAFLSPHYHPQEIYVRSTDYDRTLASAQANLAGLYPPGGAGPPNPAWQPVPVHTVPAAQDKLLRFPLRPCPRYQQLMEETTHLPQHQARMHAWKGFLEDIANLTGLGLEWATPRGIWKVYDALRCQQIHGLQLPAWATPHVLTTLGEIVAFNTLAHVGLHQVAEKARLTGGVLLDAMLQNFSEVTRRSLPLRMVMYSGHDSTLIALLAALGLYRGELPPYAACLGFEFYQESNSTFSVGLFYRNESGRDFLELVLPGCPPPCPLERFTHLTQPVRPTDRTRDCGCAQPPQGTGTPLGAQLIHAPLDQDMDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYF9</accession>
    <name>A0A151LYF9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Keratin, type II cytoskeletal 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytokeratin-8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Keratin-8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KRT8</name>
        <name evidence="17" type="ORF">Y1Q_0017728</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007029">
        <property type="protein sequence ID" value="KYO17283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYF9"/>
    <dbReference type="STRING" id="8496.A0A151LYF9"/>
    <dbReference type="eggNOG" id="ENOG502QURK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF26">
        <property type="entry name" value="KERATIN, TYPE II CYTOSKELETAL 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="5" id="KW-0416">Keratin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="16">
        <location>
            <begin position="37"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="246"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO17283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="427" mass="48081" checksum="E7D4AFC9C6CC3B3D" modified="2016-06-08" version="1">MGLGAGGGITAVSINQSLLAPLNLEIDPNMQQVRTQEKEQIKSLNNKFASFIDKVRFLEQQNQVLETKWSLLQGQRTTRSNMTGMFEAYITNLRRQLEGLGQDKLRLESELGNVQGLVEEFRSKYEDEINHRTEKENEFVLLKKDVDEAYMNKVELESRLEGLTDEISFLRQLYEEELHQLQSQVSNTSVVLSMDNNRSLDMDSIIAEVRNQYEDIANQSRAEAEGMYKIKYEELRSTASKHGDDLKNTKAEISELTRTIQRMQAEIDAVKGQRANLEAAIAEAEERGEMAVRDARGKLAELEAALQKAKQDMARQLRDYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNLSIQTKTTNYSAGLGRAFGGYDSGYGSSLSSSVYSVNSPLESAAVTKSKAIVIKKIETRDGKLVSESSDIMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZW6</accession>
    <name>A0A151LZW6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0011463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZW6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO17786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="177" mass="19754" checksum="996177C6529D5A78" modified="2016-06-08" version="1">MAAVRSNYSSQKAEGGACAVRSGGLSGRIRIFSLSRKNAEAAVPLPRAGGGVRVSLEGKRGAVRCAQDFCTCHKTLQVRSTCLKILVLKNRQSSTYDYSSYDEPQLRRLQIDTWVSKFQHGFQLYDAECWIQWKAVPRNPPEHSFVPQVNNNWEEADLASQDNIFCSVGVSLWLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1J6</accession>
    <name>A0A151M1J6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U6 snRNA (guanine-N(2))-methyltransferase THUMPD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">THUMP domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">THUMPD2</name>
        <name evidence="15" type="ORF">Y1Q_0008505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome. This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine in U6 snRNA + S-adenosyl-L-methionine = N(2)-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83423"/>
            <dbReference type="Rhea" id="RHEA-COMP:20128"/>
            <dbReference type="Rhea" id="RHEA-COMP:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:83424"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the heterodimeric THUMPD2-TRM112 methyltransferase complex; this complex forms an active tRNA methyltransferase, where TRMT112 acts as an activator of the catalytic subunit THUMPD2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M1J6"/>
    <dbReference type="eggNOG" id="ENOG502QSR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000177">
        <property type="entry name" value="THUMP domain containing 2, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF1">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="14">
        <location>
            <begin position="140"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO18383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="505" mass="56359" checksum="D3098B718038B462" modified="2016-06-08" version="1">MAXXXXXXXRYFCTAGRGLEPFVAREARARLGAAQVEQAQGKVFFSARARLRDLRALRAAERLFLLVRRRPPLLAPRPTGRMVHEIQQLVIEEPSSWLETVSRWKNLHDDEIKKENLVPQKRRSEEEINITAKKQKKEKLIEADSEEHQMEEQKKCVVPEGNNNEDSLTGRKIFLEDAPETSKDKSVESNNHSFTFRVSCRCSGAVSKVFTSQEVGRMIGVTLLKQFGWKADLRNPDLEIFVHLNDEYSVVGIPVFRLPLSNREYIKTAGLRSTIAWAMASLAEISAGAFVLDPMCGLGTILLEAAKEWPNVHYLGTDISDSQLQGACKNVKAADLMDKIELLKASVIALPLPSESIDVVISDVPFGKKFTITKDIKLVPDILREMERVLHVGGTVVLLLSQDPHKYVDGPIANYVENDASVNITTDDTNKTVIATDSNPREENGNPQSISSSNKNMEREPHNDKMKCFGSLVLVDSHGVSLGKTNAFICKYKKMPTSGVNSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2K2</accession>
    <name>A0A151M2K2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thrombospondin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0009178</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2K2"/>
    <dbReference type="STRING" id="8496.A0A151M2K2"/>
    <dbReference type="KEGG" id="amj:102576627"/>
    <dbReference type="eggNOG" id="ENOG502QRK8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14563at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000004">
        <property type="entry name" value="Adhesion G protein-coupled receptor B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000009">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000070">
        <property type="entry name" value="Thrombospondin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000067">
        <property type="entry name" value="Thrombospondin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000003">
        <property type="entry name" value="Thrombospondin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000025">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1080.10:FF:000001">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017897">
        <property type="entry name" value="Thrombospondin_3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008859">
        <property type="entry name" value="Thrombospondin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199">
        <property type="entry name" value="THROMBOSPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199:SF10">
        <property type="entry name" value="THROMBOSPONDIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05735">
        <property type="entry name" value="TSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51234">
        <property type="entry name" value="TSP3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51236">
        <property type="entry name" value="TSP_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584690" description="Thrombospondin-2" evidence="14">
        <location>
            <begin position="27"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="16">
        <location>
            <begin position="328"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="559"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="658"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="12">
        <location>
            <begin position="739"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="12">
        <location>
            <begin position="798"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="12">
        <location>
            <begin position="895"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="12">
        <location>
            <begin position="931"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="TSP C-terminal" evidence="17">
        <location>
            <begin position="970"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="856"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO18745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1182" mass="132412" checksum="BC11A901E4E93B96" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3Z1</accession>
    <name>A0A151M3Z1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TUT1</name>
        <name evidence="8" type="ORF">Y1Q_0020191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006649">
        <property type="protein sequence ID" value="KYO19234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3Z1"/>
    <dbReference type="STRING" id="8496.A0A151M3Z1"/>
    <dbReference type="GeneID" id="102568708"/>
    <dbReference type="KEGG" id="amj:102568708"/>
    <dbReference type="CTD" id="64852"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12279">
        <property type="entry name" value="RRM_TUT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000305">
        <property type="entry name" value="speckle targeted PIP5K1A-regulated poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034388">
        <property type="entry name" value="Star-PAP_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF127">
        <property type="entry name" value="SPECKLE TARGETED PIP5K1A-REGULATED POLY(A) POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO19234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="822" mass="90394" checksum="EED30C55074C39F5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M484</accession>
    <name>A0A151M484_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
        <property type="protein sequence ID" value="KYO19322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M484"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="8925" checksum="D6CAEF58AFBFC9CB" modified="2016-06-08" version="1">MLCMKSKLRLEPHCARCCTDILAGVILYLKTLPDNQSSYSFSYFGHLISSSSVLHTLLVRRSLLLSCRLPEVQRQERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4F5</accession>
    <name>A0A151M4F5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nardilysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0003517</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
        <property type="protein sequence ID" value="KYO19378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4F5"/>
    <dbReference type="STRING" id="8496.A0A151M4F5"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="145"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="305"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="495"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="781"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO19378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1073" mass="123600" checksum="C956122ACC8B6338" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M718</accession>
    <name>A0A151M718_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Protein transport protein Sec24A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SEC24A</name>
        <name evidence="20" type="ORF">Y1Q_0010830</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006262229.1">
        <property type="nucleotide sequence ID" value="XM_006262167.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M718"/>
    <dbReference type="STRING" id="8496.A0A151M718"/>
    <dbReference type="GeneID" id="102558382"/>
    <dbReference type="KEGG" id="amj:102558382"/>
    <dbReference type="CTD" id="10802"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000004">
        <property type="entry name" value="SEC24 homolog B, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000019">
        <property type="entry name" value="SEC24 homolog B, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF1">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC24A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="509"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="752"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="847"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="973"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO20294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120458" checksum="69BA3229CA71D3AD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8T2</accession>
    <name>A0A151M8T2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO20926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8T2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="123" mass="14150" checksum="6F9E33292C72DFC8" modified="2016-06-08" version="1">MLLGLHRLQGCPASPRPVSQPRGVIHVPPSVFKPKLDPENQPPRICPRRAQNPILLTGRKLLGSDKLNKWRAFSSRFYWTGVEGTGSVLKSHLKDYRIDIWEYMTTTEKVYLYTEKKSFLEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M973</accession>
    <name>A0A151M973_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0001370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="1"/>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M973"/>
    <dbReference type="STRING" id="8496.A0A151M973"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043121">
        <property type="term" value="F:neurotrophin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005030">
        <property type="term" value="F:neurotrophin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990090">
        <property type="term" value="P:cellular response to nerve growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000701">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF66">
        <property type="entry name" value="NT-3 GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO21064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="259" mass="29661" checksum="B2906089963396B2" modified="2016-06-08" version="1">MLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDIMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9C0</accession>
    <name>A0A151M9C0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9C0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7768" checksum="D67E0DDE6B13852A" modified="2016-06-08" version="1">MRWLSSSWYLGVKAFLKDGCEEAEEQEEELCNQQGSLFGCRGITNTFCALDKPSCPWEAGQSGDGFSIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MA62</accession>
    <name>A0A151MA62_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TARS</name>
        <name evidence="16" type="ORF">Y1Q_0001624</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MA62"/>
    <dbReference type="STRING" id="8496.A0A151MA62"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF38">
        <property type="entry name" value="THREONINE--TRNA LIGASE 2, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="67"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="338"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO21408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="709" mass="81822" checksum="611B1116DD66F572" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAG0</accession>
    <name>A0A151MAG0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tripartite motif-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0001699</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAG0"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16598">
        <property type="entry name" value="RING-HC_TRIM26_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12888">
        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="363"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="9">
        <location>
            <begin position="558"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="130"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="401"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO21513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="744" mass="86953" checksum="F85440F845689A74" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAX1</accession>
    <name>A0A151MAX1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COX16</name>
        <name evidence="11" type="ORF">Y1Q_0000402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAX1"/>
    <dbReference type="STRING" id="8496.A0A151MAX1"/>
    <dbReference type="GeneID" id="102576688"/>
    <dbReference type="KEGG" id="amj:102576688"/>
    <dbReference type="eggNOG" id="ENOG502S3RD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MAX1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO21677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11549" checksum="7040F8ABE0447CA2" modified="2016-06-08" version="1">MAGLRGNITLRYGVPMLLLVIGGSFGLREFAQIRYDYQKLHRKMDPALKAKLEKSTTLESEYEKIKNSSFDDWKNIRGPRPWEDSISVQAQQKEALSSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF33</accession>
    <name>A0A151MF33_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0005569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF33"/>
    <dbReference type="STRING" id="8496.A0A151MF33"/>
    <dbReference type="KEGG" id="amj:102570241"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="441"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="529"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO23115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="978" mass="106823" checksum="86DAD3FA863626A7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MG14</accession>
    <name>A0A151MG14_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Erythrocyte band 7 integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">STOM</name>
        <name evidence="6" type="ORF">Y1Q_0005809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019331401.1">
        <property type="nucleotide sequence ID" value="XM_019475856.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MG14"/>
    <dbReference type="STRING" id="8496.A0A151MG14"/>
    <dbReference type="GeneID" id="102559480"/>
    <dbReference type="KEGG" id="amj:102559480"/>
    <dbReference type="CTD" id="2040"/>
    <dbReference type="eggNOG" id="KOG2621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF115">
        <property type="entry name" value="STOMATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="49"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO23454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="281" mass="31063" checksum="517408BD79BB5ED7" modified="2016-06-08" version="1">MADKEAARARRVPESFREDSDAGLGACGWILVIVSFFFTVLTFPISIWMCIKIIKEYERAIIFRLGRILKGGAKGPGLFFVLPCTDSFIKVDMRTISFDIPPQEILTKDSVTVNVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHSMQATLDEATDDWGIKVERVEIKDVKLPVQLQRAMAAEAEAAREARAKVIAAEGEMNASRALKEASMVISESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQNLMSPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MI30</accession>
    <name>A0A151MI30_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin--tyrosine ligase-like protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TTLL9</name>
        <name evidence="6" type="ORF">Y1Q_0020281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006102">
        <property type="protein sequence ID" value="KYO24167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019355886.1">
        <property type="nucleotide sequence ID" value="XM_019500341.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MI30"/>
    <dbReference type="STRING" id="8496.A0A151MI30"/>
    <dbReference type="GeneID" id="102561683"/>
    <dbReference type="KEGG" id="amj:102561683"/>
    <dbReference type="CTD" id="164395"/>
    <dbReference type="eggNOG" id="KOG2157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF39">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO24167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="433" mass="51257" checksum="5E09B0F76FAE3692" modified="2016-06-08" version="1">MARMKVSAGHRGPPRLKEREPRACIRFKCALTNTILDVLRQRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRICHFRNHYELTRKNYIVKNLKRFRKQLEREAGKLEATKCDFFPKTFEMPSEYHLFVEEFRKYPGITWIMKPVGRSQGRGIFLFRKLKDIIDWRKDGVRADDQKDETQVENYVAQRYIENPYLIGGRKFDLRVYVLVMSYIPLKVWLYRDGFARFSNTRFTLNSIDDHYVHLTNVAVQKTAPDYDPEKGCKWMIQRFRRYLTAKHGAEAVEVLFADMDNIFIKSLQSVQKTIISDKHCFELYGYDILIDQNLKPWLLEVNASPSLTASSQEDYELKCRLLKDTLHIVDMEGRLTGKEKRVGGFDLMWNDGPVSRVEGNADTPVNASFLTNTHLGYNNDRKKQLKQLFKSLQTQQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MM07</accession>
    <name>A0A151MM07_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 436-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0023984</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005753">
        <property type="protein sequence ID" value="KYO25556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MM07"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000966">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000464">
        <property type="entry name" value="Zinc finger and SCAN domain containing 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000058">
        <property type="entry name" value="Zinc finger protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000506">
        <property type="entry name" value="Zinc finger protein 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000338">
        <property type="entry name" value="zinc finger protein 383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO25556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="537" mass="60508" checksum="2D99B69D446CBF07" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNL7</accession>
    <name>A0A151MNL7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0003885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNL7"/>
    <dbReference type="STRING" id="8496.A0A151MNL7"/>
    <dbReference type="eggNOG" id="KOG0474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF89">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="755"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO26137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="814" mass="90672" checksum="F22B25B6C77A0504" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPF4</accession>
    <name>A0A151MPF4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase DCLK1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Doublecortin-like and CAM kinase-like 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Doublecortin-like kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">DCLK1</name>
        <name evidence="23" type="ORF">Y1Q_0010396</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03005510">
        <property type="protein sequence ID" value="KYO26427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPF4"/>
    <dbReference type="STRING" id="8496.A0A151MPF4"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17140">
        <property type="entry name" value="DCX1_DCLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17069">
        <property type="entry name" value="DCX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14183">
        <property type="entry name" value="STKc_DCKL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000003">
        <property type="entry name" value="Neuronal migration protein doublecortin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000066">
        <property type="entry name" value="Serine/threonine-protein kinase DCLK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000057">
        <property type="entry name" value="Serine/threonine-protein kinase DCLK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.230:FF:000001">
        <property type="entry name" value="serine/threonine-protein kinase DCLK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Doublecortin" evidence="22">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="22">
        <location>
            <begin position="231"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="435"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="332"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="740"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO26427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="785" mass="87215" checksum="BF2F962B1A9A55C5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPV1</accession>
    <name>A0A151MPV1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">cGMP-dependent protein kinase 2</fullName>
            <ecNumber evidence="2">2.7.11.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">cGMP-dependent protein kinase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">PRKG2</name>
        <name evidence="29" type="ORF">Y1Q_0002187</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with GRIA1/GLUR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Apical cell membrane</location>
            <topology evidence="17">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPV1"/>
    <dbReference type="STRING" id="8496.A0A151MPV1"/>
    <dbReference type="eggNOG" id="KOG0614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000096">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000038">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000043">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 22 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0140">cGMP</keyword>
    <keyword evidence="12" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 29" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="9 22 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="238"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="356"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="522"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="28">
        <location>
            <begin position="781"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="528"/>
            <end position="536"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KYO26567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="831" mass="94516" checksum="579C420ADD4BE46D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR51</accession>
    <name>A0A151MR51_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.312</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Extracellular O-linked N-acetylglucosamine transferase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyltransferase-like domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">POMGNT2</name>
        <name evidence="19" type="ORF">Y1Q_0019390</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37663"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:13618"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="ChEBI" id="CHEBI:137540"/>
            <dbReference type="EC" id="2.4.1.312"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.312" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019353468.1">
        <property type="nucleotide sequence ID" value="XM_019497923.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059584788.1">
        <property type="nucleotide sequence ID" value="XM_059728805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR51"/>
    <dbReference type="STRING" id="8496.A0A151MR51"/>
    <dbReference type="GeneID" id="102567043"/>
    <dbReference type="KEGG" id="amj:102567043"/>
    <dbReference type="CTD" id="84892"/>
    <dbReference type="eggNOG" id="KOG4698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MR51"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001371">
        <property type="entry name" value="Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="486"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO26982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="578" mass="66864" checksum="8A19986F02E74C1B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSM7</accession>
    <name>A0A151MSM7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSM7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO27518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="119" mass="13901" checksum="69F810086B8D45CC" modified="2016-06-08" version="1">MRVQQILHMLENYNPPLISEKEFHLSVFLEKMRGALKTFGNCYCQTGNDFTWLRSCISISSWPLLLLTPCNSWCIWRRMKMGCLQKHYILFNITCSEKLMAQLPTRGSQPKEAETKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MT38</accession>
    <name>A0A151MT38_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger CCHC domain-containing protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZCCHC24</name>
        <name evidence="6" type="ORF">Y1Q_0005222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006264465.1">
        <property type="nucleotide sequence ID" value="XM_006264403.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MT38"/>
    <dbReference type="STRING" id="8496.A0A151MT38"/>
    <dbReference type="GeneID" id="102557792"/>
    <dbReference type="KEGG" id="amj:102557792"/>
    <dbReference type="CTD" id="219654"/>
    <dbReference type="eggNOG" id="ENOG502QRVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038672at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MT38"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057809">
        <property type="entry name" value="ZCCHC24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23490">
        <property type="entry name" value="ZCCHC24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO27659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="239" mass="26732" checksum="980D964FB3C79CB0" modified="2016-06-08" version="1">MSLLSAIDTSAASVYQPAQLLNWVYLSLQDTHQASAFDAFRPEPASSQHPELGYGKGGAELGSSLSSSYLNSFFQLQRSEALSSSLYKSASPYGSLNNIVDGLSSLTEHFSDLSLSSEARKPSKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTQ0</accession>
    <name>A0A151MTQ0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">A disintegrin and metalloproteinase with thrombospondin motifs 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0021908</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with COMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005059">
        <property type="protein sequence ID" value="KYO27887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MTQ0"/>
    <dbReference type="eggNOG" id="KOG3538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1620.60:FF:000004">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF142">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 17 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="10 17 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585451" description="A disintegrin and metalloproteinase with thrombospondin motifs 7" evidence="21">
        <location>
            <begin position="29"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="22">
        <location>
            <begin position="252"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="23">
        <location>
            <begin position="1639"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1102"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1276"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1102"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1114"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1140"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1276"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 19">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17 19">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="376"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="564"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO27887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="26">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1693" mass="187784" checksum="67DE4FB9587D94C5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVQ2</accession>
    <name>A0A151MVQ2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hepcidin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HAMP</name>
        <name evidence="8" type="ORF">Y1Q_0013912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hepcidin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004844">
        <property type="protein sequence ID" value="KYO28626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014456222.1">
        <property type="nucleotide sequence ID" value="XM_014600736.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVQ2"/>
    <dbReference type="STRING" id="8496.A0A151MVQ2"/>
    <dbReference type="GeneID" id="102575155"/>
    <dbReference type="KEGG" id="amj:102575155"/>
    <dbReference type="CTD" id="57817"/>
    <dbReference type="OrthoDB" id="9428792at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034760">
        <property type="term" value="P:negative regulation of iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010500">
        <property type="entry name" value="Hepcidin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16877">
        <property type="entry name" value="HEPCIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16877:SF0">
        <property type="entry name" value="HEPCIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06446">
        <property type="entry name" value="Hepcidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585501" evidence="7">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO28626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="100" mass="10749" checksum="C569E228E33D1A9D" modified="2016-06-08" version="1">MKVPAVCVFLLLVLLHGSPAACSALRAQADASLMPHPETGAPSHGLEADADLMPRPEIGARSHGLEVPLRRSKRFNSHFPICSYCCNCCHNKGCGFCCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVR9</accession>
    <name>A0A151MVR9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004889">
        <property type="protein sequence ID" value="KYO28538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVR9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7769" checksum="36AA30BDC2B1787F" modified="2016-06-08" version="1">MLPTNNEVAKKYFLEYCFVIPLSGQVVEKTALIYGQIKAEFCISCTSISKSGSSECTRIDPLETVLLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVZ2</accession>
    <name>A0A151MVZ2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004850">
        <property type="protein sequence ID" value="KYO28609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVZ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="115" mass="12556" checksum="D087F6268D249A33" modified="2016-06-08" version="1">MSRLPWLPGDRLKNFGASEAPEAMGGRTQDAVVSTRPSRAARELREKVIGGGSIQRVEVHPPHPSWEQGPLTNDSREDALESFLAELGTHLSNMDDESPAWGGTGKAESTQCWPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVZ3</accession>
    <name>A0A151MVZ3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0018094</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004780">
        <property type="protein sequence ID" value="KYO28733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVZ3"/>
    <dbReference type="STRING" id="8496.A0A151MVZ3"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF158">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="13">
        <location>
            <begin position="157"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="12">
        <location>
            <begin position="362"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="589"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="310"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO28733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="708" mass="78072" checksum="B7E8B5302B16B60D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWB7</accession>
    <name>A0A151MWB7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004753">
        <property type="protein sequence ID" value="KYO28792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWB7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7893" checksum="4606B3B9217C8228" modified="2016-06-08" version="1">MIKEPLVLIELRLIIHQHFICQGTRGGVTCPPMEKLRDWHVYLSPFKTVIDRESHWKTKAQAWIVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXH7</accession>
    <name>A0A151MXH7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXH7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="82" mass="8861" checksum="1685519C60751D06" modified="2016-06-08" version="1">MGRSSIIIFCDNLKSFAVAAVVLMNTFPSTMGPQAVLPTPAHSFICEVEAQGKWFFLPSVTSDKETLTDTNPDQDLAVLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXU7</accession>
    <name>A0A151MXU7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXU7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="8314" checksum="65601C35732209DE" modified="2016-06-08" version="1">MKSYYSFHFRGLEFSNFSSTPWIVSKAPGIPRNGPIPMTSGCWRNLVVNVTVSVVVELLKHSLWTLRGLWTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYT9</accession>
    <name>A0A151MYT9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0011196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004512">
        <property type="protein sequence ID" value="KYO29726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYT9"/>
    <dbReference type="STRING" id="8496.A0A151MYT9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF62">
        <property type="entry name" value="KINESIN FAMILY MEMBER 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO29726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8460" checksum="57802031FEE82DFD" modified="2016-06-08" version="1">MTEAANECSIKVLCRFRPLNQAEILRGDRFLPVFQGDDSVVLGGKPYVFDRVFPPNTTQEQVYHACAMQIVKGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYY4</accession>
    <name>A0A151MYY4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GLTSCR2</name>
        <name evidence="8" type="ORF">Y1Q_0016679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004598">
        <property type="protein sequence ID" value="KYO29629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYY4"/>
    <dbReference type="STRING" id="8496.A0A151MYY4"/>
    <dbReference type="eggNOG" id="KOG1954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO29629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="409" mass="44376" checksum="7B6AE10E6F21D8F9" modified="2016-06-08" version="1">MAAPRATARGGAARASGFLGLRPGARDPADAARPRNRGSRSRKKGWKRWRGPEAALGRELDAFLHDVSAQQRLAGGLVAEKPDESLFFVDTGNDEEAPEPAPRRGREKPLRIDLILQPDSKVPAPKDILSHQVPNGKKLKRKQRLWAALAERGTVPRAQRLLQARRQAAPPPAQPPAEIGRVDPARGFYDLWSDSNPLDSAVEGQEPWFLEQTKKLRVKRPARLCKKPSTLPAVEVVAPGASYNPSFQAHQTLLLQAHETELKRQKAEERLERQLRFPTAAEAPTQESAFQEQCEGLLEESGDEGGEELPQGEPEAPAISPALALASALPRGKKTEQQRKREKEAKNLVSGIGKSRDSLGSFPSVPPCWRVMSWASLSPGSFQIGGGGSHPREPAGLSWVAPGGGGHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZB2</accession>
    <name>A0A151MZB2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZB2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10877" checksum="C6FFC1D4CAD1CDA0" modified="2016-06-08" version="1">MELQTPLNYAKNQAADLKEGHVTSADETTLHHKIWAVPKTELGKELVSLSNTRKQSTSNITEDKRVKENFTASTVLHICRIYEKRRIKENIADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZD9</accession>
    <name>A0A151MZD9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Major histocompatibility complex class I-related protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0009496</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MHC class I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004483">
        <property type="protein sequence ID" value="KYO29877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZD9"/>
    <dbReference type="STRING" id="8496.A0A151MZD9"/>
    <dbReference type="KEGG" id="amj:102567483"/>
    <dbReference type="eggNOG" id="ENOG502RQEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8936120at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002474">
        <property type="term" value="P:antigen processing and presentation of peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000204">
        <property type="entry name" value="Major histocompatibility complex, class I-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF242">
        <property type="entry name" value="MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0490">MHC I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="179"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO29877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="315" mass="35825" checksum="264FB50354F513BF" modified="2016-06-08" version="1">MDTWDTAADRHPGAFLLSPLDVPDFTAVAYVDDQLLLHYNSKTQREEPRGDWVQGAVSPHFWDKETRALRRWQEGFDTNLATLWYRYNQMGGSRTLQLTYSCELHEDNSTGGHMQLGYDRGDFISYDPGTRTWIAAPTQAQRTQHTWNEDRALLQDTKAYLEETCVAWLQQYLLQSKHPVAQVSDRPSQDGRTTLSCWVHGFYPKNISVVWLKNGEGQTQETSHSGVLLSGDGTYQTWATMEIDPSNNHDYACLVEHASLGLVLCVSWDKGRTEYHWMLIVGIVVGVVLILVIVVMGAAVFFLSLVLLEGRRKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N008</accession>
    <name>A0A151N008_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="12">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SRMS</name>
        <name evidence="16" type="ORF">Y1Q_0021153</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="12"/>
    <dbReference type="EMBL" id="AKHW03004329">
        <property type="protein sequence ID" value="KYO30067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N008"/>
    <dbReference type="STRING" id="8496.A0A151N008"/>
    <dbReference type="eggNOG" id="KOG0197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151N008"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05148">
        <property type="entry name" value="PTKc_Srm_Brk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000458">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000078">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="119"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="229"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO30067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="491" mass="56068" checksum="1F34CAF1EE8B070F" modified="2016-06-08" version="1">MEQFVRKRLTFLASFWNKLRPRSVPDNCSLGYFGPDPVSLQPDQDPDPALPASPLFVALYDFTARSTNELSVSRGDKLCVYKDVGEYVLARRLSGDSVGYVPANYVAKISQETPSHQLWYFSGISRHEAERLLLSPPNEHGSFLIRDSESSKGEYSLSVRNQAKVSHFRICKCPDGGLYIQKGHTFPSMEELLAFYMENWKAIQSPLVKPCVLKTLPERDEWERPRSEFTLRKKLGEGNFGEVWEGLWRNTVPVAIKIIKQADMKAEDFTKEIQNLKSLKHEKLIQLHAVCSRGEPVFIITELMKKGNLQSYLNSLEGKSLSTLHLLDMACQVADGMTYLEEKHIVHRDLAARNILVGDDLTCKIADFGLARLLKDDIYSTSGSTKIPVKWTAPEAANYRTYSLKSDIWSYGILLYEVFTYGQTPYEGMTNQETIQQITRGYRLPRPSTCPSEIYLVMLECWKGNAEDRPTFFALREKLNSIYSRVYKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0N8</accession>
    <name>A0A151N0N8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EMILIN-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EMILIN1</name>
        <name evidence="11" type="ORF">Y1Q_0010025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004232">
        <property type="protein sequence ID" value="KYO30371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0N8"/>
    <dbReference type="STRING" id="8496.A0A151N0N8"/>
    <dbReference type="eggNOG" id="ENOG502RIZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030023">
        <property type="term" value="F:extracellular matrix constituent conferring elasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000010">
        <property type="entry name" value="EMILIN-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF1">
        <property type="entry name" value="EMILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07546">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EMI" evidence="10">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="9">
        <location>
            <begin position="867"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="826"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO30371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1017" mass="107378" checksum="375C24CD444F4C15" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0X1</accession>
    <name>A0A151N0X1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HLA class I histocompatibility antigen, alpha chain F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0006453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004228">
        <property type="protein sequence ID" value="KYO30377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0X1"/>
    <dbReference type="STRING" id="8496.A0A151N0X1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002474">
        <property type="term" value="P:antigen processing and presentation of peptide antigen via MHC class I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF242">
        <property type="entry name" value="MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0490">MHC I</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MHC class I-like antigen recognition-like" evidence="10">
        <location>
            <begin position="67"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO30377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="171" mass="19025" checksum="6EF6711C4E152BBC" modified="2016-06-08" version="1">MVTTDPAASCGLRCGPLRPSLRGSTLRVCAQRLDAAHEAAAKVAPGSRLLLLLLLLGAETVPGAHAGSHSYRHFYTAVSDPSLDVPVFTAVGYVDDQQILRYDSETQRQEPRGDWVQGAVDQDFWDGETRSLRRWQDGFKRNLLTLRHRYNQTGGECEQAGVSRRPWGPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0X2</accession>
    <name>A0A151N0X2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatase and actin regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PHACTR1</name>
        <name evidence="14" type="ORF">Y1Q_0019074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Binds PPP1CA and actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004164">
        <property type="protein sequence ID" value="KYO30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0X2"/>
    <dbReference type="STRING" id="8496.A0A151N0X2"/>
    <dbReference type="eggNOG" id="KOG4339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043149">
        <property type="term" value="P:stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF6">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="11">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="410"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU301113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO30451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="617" mass="69357" checksum="C963A792AC9D8F33" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N149</accession>
    <name>A0A151N149_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein</fullName>
            <shortName evidence="6">Cnt-b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Centaurin-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACAP1</name>
        <name evidence="10" type="ORF">Y1Q_0007307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endosome membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004158">
        <property type="protein sequence ID" value="KYO30468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N149"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13250">
        <property type="entry name" value="PH_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000007">
        <property type="entry name" value="Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000026">
        <property type="entry name" value="Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF197">
        <property type="entry name" value="ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="229"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="9">
        <location>
            <begin position="365"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO30468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="560" mass="62524" checksum="6275452CE47F124C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4R2</accession>
    <name>A0A151N4R2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RasGAP-activating-like protein 1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RASAL1</name>
        <name evidence="10" type="ORF">Y1Q_0022853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019349156.1">
        <property type="nucleotide sequence ID" value="XM_019493611.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4R2"/>
    <dbReference type="STRING" id="8496.A0A151N4R2"/>
    <dbReference type="GeneID" id="102560548"/>
    <dbReference type="KEGG" id="amj:102560548"/>
    <dbReference type="CTD" id="8437"/>
    <dbReference type="eggNOG" id="KOG2059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N4R2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04054">
        <property type="entry name" value="C2A_Rasal1_RasA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13369">
        <property type="entry name" value="PH_RASAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05135">
        <property type="entry name" value="RasGAP_RASAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000283">
        <property type="entry name" value="Ras GTPase-activating protein 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037776">
        <property type="entry name" value="RASAL_RasGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF3">
        <property type="entry name" value="RASGAP-ACTIVATING-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="116"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="9">
        <location>
            <begin position="307"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="572"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO31782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="818" mass="93743" checksum="2E609198E9A0C1BE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4W2</accession>
    <name>A0A151N4W2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat and SOCS box-containing protein 2 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">WSB2</name>
        <name evidence="7" type="ORF">Y1Q_0022820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4W2"/>
    <dbReference type="STRING" id="8496.A0A151N4W2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03733">
        <property type="entry name" value="SOCS_WSB_SWIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051983">
        <property type="entry name" value="WSB_SOCS-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622:SF1">
        <property type="entry name" value="WD REPEAT AND SOCS BOX-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO31737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="388" mass="43201" checksum="834E7066BF502BF6" modified="2016-06-08" version="1">MGLCVMCTHCLSREEPVLLAELKPGRPQQYDWKSSCETWSVAFSPDGAWFAWSQGHCIVKLIPWPLEEAELGCRTIERKSCSTKADTRGRGGAKEKTLECGQIVWGLSFSTREQDGLQAPSPSCLILATGLNDGQIKVWEVQTGHLLFNLSGHQDVVRDLSFTPNGNLILVSASRDKTLRVWDLSRDGKQVQVLSGHMQWVLASRGHRNAAHTWPNPESIPLAFPRPSCGACDSALLVTASYDACVIMWDPYTGEQLRTLRHGPLHSALDYGTDIHASSLRSVCFSPEGLYLATVADDRLLRIWALELRTPVAFAPMTNGLCCVYFPHGGFIATGTRDGHVQFWTAPRVLSSLKHLCRKALRTFLTTYQVLALPIPKKMKEFLTYRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6U9</accession>
    <name>A0A151N6U9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003905">
        <property type="protein sequence ID" value="KYO32574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6U9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="14432" checksum="9C1FEC7548C4429F" modified="2016-06-08" version="1">MQNTNDTYLQNPLKSKILNVKEGEKARLNPLQLDSHLPCQNERHQENKERRRNHILFTAAWSRLDPHTAVRELKSIYGPHAANTCPILSNVWQPTGCQALAGSPELQAEMEKYQSTRRTFLNTGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7Y2</accession>
    <name>A0A151N7Y2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1</fullName>
            <shortName evidence="13">ARD</shortName>
            <shortName evidence="13">ARD'</shortName>
            <shortName evidence="13">Fe-ARD</shortName>
            <shortName evidence="13">MTCBP-1</shortName>
            <shortName evidence="13">Ni-ARD</shortName>
            <ecNumber evidence="13">1.13.11.53</ecNumber>
            <ecNumber evidence="13">1.13.11.54</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">ADI1</name>
        <name evidence="13" type="synonym">MTCBP1</name>
        <name evidence="14" type="ORF">Y1Q_0011258</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="13">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.53" evidence="13"/>
    <dbReference type="EC" id="1.13.11.54" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03003826">
        <property type="protein sequence ID" value="KYO32930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006265578.1">
        <property type="nucleotide sequence ID" value="XM_006265516.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7Y2"/>
    <dbReference type="STRING" id="8496.A0A151N7Y2"/>
    <dbReference type="GeneID" id="102560467"/>
    <dbReference type="KEGG" id="amj:102560467"/>
    <dbReference type="CTD" id="55256"/>
    <dbReference type="eggNOG" id="KOG2107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N7Y2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000031">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0533">Nickel</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="180" mass="21746" checksum="15C6830B94376B43" modified="2016-06-08" version="1">MVQAWYMDEAAAHPEKPHECEPARPVGLEQLRRLGVLYWKLDADNYETDPELARIRRERNYSWMDIITIDKDKLPNYEDKIKIFYEEHLHLDEEIRYILEGSGYFDVRDKDDKWIRIFMQKGDMITLPAGIYHRFTLDENNYVKAMRLFAGEPIWTPYNRPADHFPARRQYLQFMEQAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NA00</accession>
    <name>A0A151NA00_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Caspase-8</fullName>
            <ecNumber evidence="14">3.4.22.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CASP18</name>
        <name evidence="21" type="ORF">Y1Q_0008761</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).</text>
            <dbReference type="EC" id="3.4.22.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.61" evidence="14"/>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NA00"/>
    <dbReference type="STRING" id="8496.A0A151NA00"/>
    <dbReference type="eggNOG" id="KOG3573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08334">
        <property type="entry name" value="DED_Caspase_8_10_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000016">
        <property type="entry name" value="CASP8 and FADD-like apoptosis regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000008">
        <property type="entry name" value="caspase-8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="DED" evidence="18">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="18">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="20">
        <location>
            <begin position="195"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="19">
        <location>
            <begin position="339"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR038001-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO33606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="424" mass="48445" checksum="01950B5DE5E708B9" modified="2016-06-08" version="1">MKKQESIQDSKDFFQKLQEKGMIAEDDLTFIKELLLRINRIDLLTDKLRSSREEMEQELKIPGKAKISTYRLLLYKIAEELTEDDVVNVKFLLQTCIAKNKLQNSTTVLKIFIEMEKIGIMNGGDLKVLKDILQRLRCDLVKNINAYEEEIKGSSMFLIGPGHQEVACSKPNESVDLEEMTIPQLKRPYKMENYPHGYCVILNNYNFKDPDNTRSGADKDSEALKKVFTSLQFQIIEHSNLEAKQMLEIMQMYSKKDHSNMDCFICCLLSHGDKGQLKGTDWKSVPIKGLVSCFTGSNCKSLVGKPKLFFIQACQGTHKQQSISVEEDGCQKLETDASLLPSVPDWADILIGMATVEDYQCYRYTDRGSVYIQCLCKEMESLCPHHVDLVTILTNVNKDVGDKVFQGSKQMPEIISTLRRQLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBT8</accession>
    <name>A0A151NBT8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0023690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003562">
        <property type="protein sequence ID" value="KYO34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBT8"/>
    <dbReference type="STRING" id="8496.A0A151NBT8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF188">
        <property type="entry name" value="ACIDIC MAMMALIAN CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="81"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="164" mass="18653" checksum="9C0CA60E14E25CB0" modified="2016-06-08" version="1">MVSTAQNRQTFIQSAITFLRKGNGLYNGDKKPYRNCTQWRETCSIKSSERQHWISTQAKMAKLFLLTGLVLLLNAQIGSAYVLSCYFTNWGQYRPSPGKYFPKDIDPCLCTHLLYAFAGMTNNEIATIEWNDVTLYKSFNDLKNQNSELKTLLSIGGWNFGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBZ8</accession>
    <name>A0A151NBZ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipoma HMGIC fusion partner</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0007610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003532">
        <property type="protein sequence ID" value="KYO34334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBZ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF12">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO34334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9529" checksum="0C25A26261321F27" modified="2016-06-08" version="1">MGRLKKPYTFEQWPGLLIGSGCALYPLGWDSEEVRQTCGNLSNQFELGTCEIGWAYYCTGGGAAAAMLICTWLACFSGKKQKQYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ND07</accession>
    <name>A0A151ND07_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc finger protein 883-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0020173</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003359">
        <property type="protein sequence ID" value="KYO34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ND07"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000638">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000360">
        <property type="entry name" value="zinc finger protein 572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000213">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB-related" evidence="16">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="102"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="174"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="76961" checksum="44672ECA402C450F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDZ5</accession>
    <name>A0A151NDZ5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDZ5"/>
    <dbReference type="STRING" id="8496.A0A151NDZ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11536" checksum="02FED46A7523C536" modified="2016-06-08" version="1">MLRKLERTIQSFKNGKTAGSDGLPKEFYLTFWNLVVPDLLEFFRECLQEGQLDVGMDWDLMTLLYKKGLREELKNWRPITLLNFNYKLLWMSDSNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NF58</accession>
    <name>A0A151NF58_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0007993</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NF58"/>
    <dbReference type="STRING" id="8496.A0A151NF58"/>
    <dbReference type="KEGG" id="amj:106736802"/>
    <dbReference type="eggNOG" id="KOG0210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000008">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF50">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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    <sequence length="1128" mass="127487" checksum="C30159A0ED9C6C21" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFW4</accession>
    <name>A0A151NFW4_ALLMI</name>
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        <recommendedName>
            <fullName evidence="10">Phosphatase and actin regulator 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PHACTR4</name>
        <name evidence="12" type="ORF">Y1Q_0013846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Binds PPP1CA and actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="10">Cell projection</location>
            <location evidence="10">Lamellipodium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="7 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 10" id="KW-0966">Cell projection</keyword>
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    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO35640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="738" mass="81315" checksum="41A4345399C11123" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGQ3</accession>
    <name>A0A151NGQ3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Coiled-coil domain-containing protein 65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CCDC65L</name>
        <name evidence="14" type="ORF">Y1Q_0017289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DRC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003087">
        <property type="protein sequence ID" value="KYO35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGQ3"/>
    <dbReference type="STRING" id="8496.A0A151NGQ3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="188" mass="21992" checksum="7DB3692627266CED" modified="2016-06-08" version="1">MPRKGRKGPATPGLSEEERLLLMQQKLLVAEEQSKKKEDVLRQFLKDKLAKEEHNSTINANRVNMQWRQLLREAKAKELRRDIEILSQTFERVVDCKDHVIQVLAKDLSEAEAQHAHALRSHLHNIDQLLQVQRCRLRYLEEDYNTELEALKKEFETERYWGRGWGIGLGQRGEGDEQPAQECPRCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGS2</accession>
    <name>A0A151NGS2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">POU domain class 2-associating factor 1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">POU2AF1</name>
        <name evidence="8" type="ORF">Y1Q_0010163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGS2"/>
    <dbReference type="STRING" id="8496.A0A151NGS2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070974">
        <property type="term" value="F:POU domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000097">
        <property type="entry name" value="NF-kappa-B inhibitor zeta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047571">
        <property type="entry name" value="OCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015389">
        <property type="entry name" value="PD-C2-AF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF7">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09310">
        <property type="entry name" value="PD-C2-AF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52003">
        <property type="entry name" value="OCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCA" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO35725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="563" mass="62287" checksum="2F113C8317DB2A25" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NH48</accession>
    <name>A0A151NH48_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003015">
        <property type="protein sequence ID" value="KYO36143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NH48"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7270" checksum="114890B89A13AEC1" modified="2016-06-08" version="1">MSSGSTAPGSIGWSSVLYVASGLASIGGLYYAYGLVTSSRDRYNERLRFSEEARERELKAYPQTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJ86</accession>
    <name>A0A151NJ86_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein GIPC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GIPC2</name>
        <name evidence="3" type="ORF">Y1Q_0020860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GIPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJ86"/>
    <dbReference type="STRING" id="8496.A0A151NJ86"/>
    <dbReference type="GeneID" id="102567128"/>
    <dbReference type="KEGG" id="amj:102567128"/>
    <dbReference type="CTD" id="54810"/>
    <dbReference type="eggNOG" id="KOG3938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6509831at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21180">
        <property type="entry name" value="GH2_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23078">
        <property type="entry name" value="PDZ_GIPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000097">
        <property type="entry name" value="PDZ domain-containing protein GIPC1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055349">
        <property type="entry name" value="GH2_GIPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056814">
        <property type="entry name" value="GIPC1-3_GH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017379">
        <property type="entry name" value="GIPC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259:SF3">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN GIPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259">
        <property type="entry name" value="RGS-GAIP INTERACTING PROTEIN GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25083">
        <property type="entry name" value="GIPC1_GH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25082">
        <property type="entry name" value="GIPC1_GH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038083">
        <property type="entry name" value="UCP038083_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="118"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO36820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="317" mass="34926" checksum="22ED05E72778A6A7" modified="2016-06-08" version="1">MPLGLRGKKKAKSKDTSKLVESEEAAAAAAAASSAAAQPRARLHFHTQLAHGSPTGRVEGFSSVRELYERIAHAFHIAPAEIMFCTLNTHRIDMDKLLGGQIGLEDFIFAHIKGPKKEVDILKSEESLGLTITDNGTGCAFIKRIKEGSLIDQIKMVCVGDHIESINGKNVVGYRHYEVAKLLKALEKGQTFKLQLIEPMKAFEMIEPRLKGGNLSETKISRGRETLRLRSKGPATLEEMPSDVEEKAIKKVDDLLEMYMGIRDIELAATMVEAGRDKKNPDEFAVALDEALGDFAFPDEFVFDVWGAIGDAKEGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJR8</accession>
    <name>A0A151NJR8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AGAP1</name>
        <name evidence="6" type="ORF">Y1Q_0013266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002909">
        <property type="protein sequence ID" value="KYO36765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJR8"/>
    <dbReference type="STRING" id="8496.A0A151NJR8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01250">
        <property type="entry name" value="PH_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000211">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000459">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000545">
        <property type="entry name" value="arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819:SF3">
        <property type="entry name" value="ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45819">
        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="845"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="745"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="931"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO36765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1102" mass="114459" checksum="9637D5AC1A82E17F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK22</accession>
    <name>A0A151NK22_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK22"/>
    <dbReference type="STRING" id="8496.A0A151NK22"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="13858" checksum="DBB93A2DBE8C996E" modified="2016-06-08" version="1">MNATEVWELAQEAWKSGVLLMEVLWTCFFPASQQILSLLSLDGIREEKLLREEFEAPITGVPRIVEKELGGSTVLDIGCYVIHFACMVFRGEKPKSITASGFLCPTGLKSPILPLAESELAASIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLD3</accession>
    <name>A0A151NLD3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Sodium channel regulatory subunit beta-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Sodium channel regulatory subunit beta-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">SCN1B</name>
        <name evidence="29" type="ORF">Y1Q_0015729</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">A voltage-gated sodium (Nav) channel consists of an ion-conducting pore-forming alpha subunit functional on its own that is regulated by one or more beta subunits. Forms homodimers and homotrimers. SCN3B is non-covalently associated with alpha subunits and induces the formation of alpha subunit oligomers, including trimers. Interacts with SCN5A/Nav1.5; regulatory subunit of SCN5A/Nav1.5. Interacts with SCN7A/Nav2.1; probable regulatory subunit of SCN7A/Nav2.1. Interacts with SCN10A; regulatory subunit of SCN10A/Nav1.8. Interacts with NFASC; probably involved in targeting the sodium channels to the nodes of Ranvier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002719">
        <property type="protein sequence ID" value="KYO37479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014458877.1">
        <property type="nucleotide sequence ID" value="XM_014603391.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLD3"/>
    <dbReference type="STRING" id="8496.A0A151NLD3"/>
    <dbReference type="GeneID" id="102568564"/>
    <dbReference type="KEGG" id="amj:102568564"/>
    <dbReference type="CTD" id="6324"/>
    <dbReference type="eggNOG" id="ENOG502R0UM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8868224at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019871">
        <property type="term" value="F:sodium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086002">
        <property type="term" value="P:cardiac muscle cell action potential involved in contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000375">
        <property type="entry name" value="Sodium channel beta 1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027098">
        <property type="entry name" value="Na_channel_b1/b3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10546:SF2">
        <property type="entry name" value="SODIUM CHANNEL SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10546">
        <property type="entry name" value="SODIUM CHANNEL SUBUNIT BETA-1 AND 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="19 29" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 27" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0915">Sodium</keyword>
    <keyword evidence="6" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586170" description="Sodium channel regulatory subunit beta-1" evidence="27">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00024210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KYO37479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="219" mass="24463" checksum="DD4151189B59AACC" modified="2016-06-08" version="1">MAPLGPALLLPLVLVASCWAGCVEVDSETEAVTGKTFKIQCISCKKRSETTAEAYTEWYFKQKGADSFDKILRFEPDTDLLVLDDRFVNLVVWNGSKSTRDLQDLSIFLLNVTYDHAGEYLCRVDRNLTFDGYVFNTVINKTIHVTVVDKANRDIASIISEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLD8</accession>
    <name>A0A151NLD8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thy-1 membrane glycoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Thy-1 antigen</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">THY1</name>
        <name evidence="17" type="ORF">Y1Q_0013784</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002638">
        <property type="protein sequence ID" value="KYO37626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLD8"/>
    <dbReference type="STRING" id="8496.A0A151NLD8"/>
    <dbReference type="eggNOG" id="ENOG502S18P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051894">
        <property type="term" value="P:positive regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001828">
        <property type="entry name" value="Thy-1 membrane glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033292">
        <property type="entry name" value="THY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19226">
        <property type="entry name" value="THY-1 MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19226:SF2">
        <property type="entry name" value="THY-1 MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586163" description="Thy-1 membrane glycoprotein" evidence="15">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="16">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO37626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="195" mass="21885" checksum="0F0E27BACD4EF817" modified="2016-06-08" version="1">MNPTLSIAVLLAVLQAAQCQTIRDLSACLLGQSLRVDCHFENKTSNPLTYEFSIIRDTRKRVINSNMNIPESTYRARSNITLHRNLIHLYLSSFTTSDEGLYICELKATNDYTGHQVKNITVIKDKLEKCAGISLLIQNTSWLLLLLLSLPLLQAVDFRLTQRLSPRPIPAWSPAEPSAQTSRPVPQTVLGPRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NM92</accession>
    <name>A0A151NM92_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ELOF1</name>
        <name evidence="9" type="ORF">Y1Q_0006512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter required to anchor TC-NER factors to RNA polymerase II: stably positions UVSSA and the DCX(ERCC8) complex (also named CSA complex) on arrested RNA polymerase II, leading to neddylation and activation of the DCX(ERCC8) complex and ubiquitination of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002548">
        <property type="protein sequence ID" value="KYO37946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NM92"/>
    <dbReference type="STRING" id="8496.A0A151NM92"/>
    <dbReference type="GeneID" id="102573398"/>
    <dbReference type="KEGG" id="amj:102573398"/>
    <dbReference type="CTD" id="84337"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000002">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO37946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="130" mass="14543" checksum="784660EF8532F70C" modified="2016-06-08" version="1">MYRSLLETRPRCEAGGRWGLGATPLTRKCPPPIWNCGGAARRGEQAGMGRRKSKRKPPPKKKMTGTLETQFTCPFCNHEKSCDVKMDRARNTGVISCTVCLEEFQTPITYLSEPVDVYSDWIDACEAANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMF1</accession>
    <name>A0A151NMF1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002566">
        <property type="protein sequence ID" value="KYO37900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMF1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="16639" checksum="F3B6DF20B01B8A3C" modified="2016-06-08" version="1">MHHLVRNKINELNLTQKLPASPGSRSSAICETMSDRMKHVSVCNMKRWRKIWLTLCSFSPASSFQGLFTAKFKELDSACDFSSVPKQLWGKDWSRTCSYNEDEKKGSRSSSSLNVHHGFCYPQNKGMVLLKDFPIHFLYACQVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NN20</accession>
    <name>A0A151NN20_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-MWFE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase MWFE subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NDUFA1</name>
        <name evidence="16" type="ORF">Y1Q_0015506</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006277436.1">
        <property type="nucleotide sequence ID" value="XM_006277374.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NN20"/>
    <dbReference type="STRING" id="8496.A0A151NN20"/>
    <dbReference type="GeneID" id="102564782"/>
    <dbReference type="KEGG" id="amj:102564782"/>
    <dbReference type="CTD" id="4694"/>
    <dbReference type="eggNOG" id="ENOG502S3S5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NN20"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO38221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="8335" checksum="EC12A66EAECC9650" modified="2016-06-08" version="1">MWYEILPFAGMTWLCLVVPGISLTYFYRYSNGGKEKRAARNHFQWTLMERDRFVSGVNIYHRSKGLENID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNC8</accession>
    <name>A0A151NNC8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNC8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="8059" checksum="EC95793A5AC0CAC3" modified="2016-06-08" version="1">MLTPLLEVGPNLAQRVKMCNLTNAQGEDKRTAGPEAVEGSERECYILCKSMEVGQYKLKLSRYLKNTQANNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP06</accession>
    <name>A0A151NP06_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP06"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="13029" checksum="4DF3A46B51C703AA" modified="2016-06-08" version="1">MAEFILSLLNTRVLRAFSPLVRKLSTTSRRRERDIYKRFYQIRRTERRSPLTLESMPGHHCVLQKVIQRQQQSSPSHNKISASAYPPLLAQKISHIHMDESMETVLLFHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRX9</accession>
    <name>A0A151NRX9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002337">
        <property type="protein sequence ID" value="KYO39225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRX9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO39225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="128" mass="14738" checksum="FEC60431042BD5F9" modified="2016-06-08" version="1">MKNFLQVLAKEKKLKCPLATFGIVPCCLWAYLASQDWWLHVLQTTWDDKQWLECFHMTQATFQELLDQLHPQLEQQATTMQPPLPTDTRPAIALVKLATHANVCHVGHLFSVDRATARKADMEVYSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRY4</accession>
    <name>A0A151NRY4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">General transcription factor IIH subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">General transcription factor IIH polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GTF2H3</name>
        <name evidence="16" type="ORF">Y1Q_0018680</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 15">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 15">Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014453936.2">
        <property type="nucleotide sequence ID" value="XM_014598450.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRY4"/>
    <dbReference type="STRING" id="8496.A0A151NRY4"/>
    <dbReference type="GeneID" id="102572859"/>
    <dbReference type="KEGG" id="amj:102572859"/>
    <dbReference type="CTD" id="2967"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000045">
        <property type="entry name" value="general transcription factor IIH subunit 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00627">
        <property type="entry name" value="tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO39617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="328" mass="36005" checksum="D1C8879A3B21AB10" modified="2016-06-08" version="1">MSLAGACPVPRGAAVPGLTPVAFSEDELSLLVAVVDANPIWWGQKAQGGGEFTLSKCLDAVMVMGNSHLFMNRNNRLAVIASHTQESRFLYPGKRWAFADLFGDGGSCVESNCAGSKDGKYELLTAINETIAEEIKDLMTKTDVKGQQTETLLAGSIAKALCYIHRLTKEVKANQEIKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLENDSGLLQQACDITGGIYLKVPHMPSLLQYLLWVFLPDQEQRSQLILPPPIHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICSTCETAFKISLPPVLKAKKKKLRVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTQ2</accession>
    <name>A0A151NTQ2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0004401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0561 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001979">
        <property type="protein sequence ID" value="KYO40291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTQ2"/>
    <dbReference type="eggNOG" id="ENOG502S396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018888">
        <property type="entry name" value="UPF0561"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34256">
        <property type="entry name" value="UPF0561 PROTEIN C2ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34256:SF1">
        <property type="entry name" value="UPF0561 PROTEIN C2ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10573">
        <property type="entry name" value="UPF0561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO40291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="143" mass="16523" checksum="BF45C0BFA40A5CB9" modified="2016-06-08" version="1">MSHGFVRSIRRNQIARDDYDREMKQAKEKVKKRHTPTPPRPRKPDQQVYHPRRRSQPDPSYSLDYEGSSESSSSPEPDPRGPELFCLEFEADSGDVTAVIVHQDDSPEEVAQQVCAHSPLEPVLRQALCQRVREELHKRQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU41</accession>
    <name>A0A151NU41_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001930">
        <property type="protein sequence ID" value="KYO40407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NU41"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="99" mass="11001" checksum="898BA6DCB6B5A702" modified="2016-06-08" version="1">MSILLLKVTKEITCLGTWFWCFHFQQYILQRGRIFYPKQQSESPEIAEGRQTVQKDLEGKAAGVFAGQKRASFADVGSLSKTHCPSVFTGFCSASGSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU52</accession>
    <name>A0A151NU52_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AT-rich interactive domain-containing protein 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARID5A</name>
        <name evidence="9" type="ORF">Y1Q_0004395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001979">
        <property type="protein sequence ID" value="KYO40284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275062.1">
        <property type="nucleotide sequence ID" value="XM_006275000.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NU52"/>
    <dbReference type="STRING" id="8496.A0A151NU52"/>
    <dbReference type="GeneID" id="102574709"/>
    <dbReference type="KEGG" id="amj:102574709"/>
    <dbReference type="CTD" id="10865"/>
    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NU52"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16884">
        <property type="entry name" value="ARID_ARID5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000004">
        <property type="entry name" value="AT-rich interactive domain-containing protein 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF25">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="8">
        <location>
            <begin position="80"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO40284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="618" mass="67099" checksum="062EE8CF41E91139" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUG2</accession>
    <name>A0A151NUG2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUG2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7854" checksum="8C28B3BE8DF9315E" modified="2016-06-08" version="1">MKQDIPACLRWALVSTVLQEEMPPVVAENEDKDCESAQKNKIVLDSCGTWDKQRLQFSTVAFQEDYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUI6</accession>
    <name>A0A151NUI6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0009607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUI6"/>
    <dbReference type="STRING" id="8496.A0A151NUI6"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000004">
        <property type="entry name" value="gamma-adducin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF5">
        <property type="entry name" value="GAMMA-ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="12">
        <location>
            <begin position="122"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="518"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="650"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO40592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="692" mass="77610" checksum="C1B73858CDB6E134" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVG7</accession>
    <name>A0A151NVG7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prominin-1-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0015741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001900">
        <property type="protein sequence ID" value="KYO40670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVG7"/>
    <dbReference type="eggNOG" id="KOG4331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071914">
        <property type="term" value="C:prominosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF4">
        <property type="entry name" value="PROMININ-1-A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO40670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="186" mass="20140" checksum="3EC4313A420838DF" modified="2016-06-08" version="1">MALRNLSQPTYEPPPASLAGSTPGLDSMAHGFLGLVQPNAFPAELLSRLIQEPAHITEPATYKQVLSYEMGFLVCAAIGLLFILLMPLGGLCFCCCRCCGRCGGRKYQKQDQRMGCRRRALWTTLLLLSGLLLAWNVCAFVTNARISRAVGSSFSTFNSSMGNLSTYLDDIPQQVDFVRGGGLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW04</accession>
    <name>A0A151NW04_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin-like protein KIF22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KIF22</name>
        <name evidence="11" type="ORF">Y1Q_0011386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001810">
        <property type="protein sequence ID" value="KYO40913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NW04"/>
    <dbReference type="STRING" id="8496.A0A151NW04"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01376">
        <property type="entry name" value="KISc_KID_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="34"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO40913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="538" mass="59439" checksum="4FCA5B05E1776B8C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW81</accession>
    <name>A0A151NW81_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Seizure 6-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0019590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001719">
        <property type="protein sequence ID" value="KYO41048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NW81"/>
    <dbReference type="STRING" id="8496.A0A151NW81"/>
    <dbReference type="eggNOG" id="ENOG502QS53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000009">
        <property type="entry name" value="Seizure related 6 homolog like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000010">
        <property type="entry name" value="Seizure related 6 homolog like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF2">
        <property type="entry name" value="SEIZURE 6-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0768">Sushi</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="90"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="210"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="272"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="387"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="514"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO41048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="71879" checksum="2BC6D6D08BA2E812" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWD1</accession>
    <name>A0A151NWD1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RBCK1</name>
        <name evidence="15" type="ORF">Y1Q_0010558</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03001740">
        <property type="protein sequence ID" value="KYO41033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWD1"/>
    <dbReference type="STRING" id="8496.A0A151NWD1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20345">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16633">
        <property type="entry name" value="mRING-HC-C3HC3D_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01799">
        <property type="entry name" value="Ubl_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000007">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000140">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000137">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047558">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057468">
        <property type="entry name" value="HOIL-1/Sharpin_LTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047559">
        <property type="entry name" value="HOIL1_RBR_mRING-HC-C3HC3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01053">
        <property type="entry name" value="LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF35">
        <property type="entry name" value="RANBP-TYPE AND C3HC4-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25393">
        <property type="entry name" value="LTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="312"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO41033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="521" mass="58330" checksum="EB484243759D9158" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWM8</accession>
    <name>A0A151NWM8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reactive oxygen species modulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein MGR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ROMO1</name>
        <name evidence="12" type="ORF">Y1Q_0013726</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001786">
        <property type="protein sequence ID" value="KYO40979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWM8"/>
    <dbReference type="STRING" id="8496.A0A151NWM8"/>
    <dbReference type="GeneID" id="102558412"/>
    <dbReference type="KEGG" id="amj:102558412"/>
    <dbReference type="CTD" id="140823"/>
    <dbReference type="eggNOG" id="KOG4096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO40979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="102" mass="11101" checksum="986D086445A3ED87" modified="2016-06-08" version="1">MRHQSESEVRASEGRTQHRPRRKMPVTVGPYGQSQPNCFDRVKMGFMMGFAVGMAAGALFGTFSSLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXA9</accession>
    <name>A0A151NXA9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 80 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM80</name>
        <name evidence="8" type="ORF">Y1Q_0006312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXA9"/>
    <dbReference type="STRING" id="8496.A0A151NXA9"/>
    <dbReference type="eggNOG" id="KOG4502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO41531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="142" mass="15786" checksum="72CD30B97C09E622" modified="2016-06-08" version="1">MAAAKRGRTSSVLSSVPLQILFYLNRVYYIFYFLATLLMIIYKSQVFSYPDNFLALDLALLFIMAILEAVRLYLGTKGNLTEEEASLGVSLVITVGSAILSVYFLVWETYVLKADVIINAILLVTYGLEAILQIIAIAAFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY02</accession>
    <name>A0A151NY02_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0006277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY02"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="11010" checksum="39BE9A4B499889AF" modified="2016-06-08" version="1">MEVWTPLNSSNKISLAASPQTRDMTQLSPAHKSKVISLALVEFHKSKTVHYLNQTLSPEPAEPAPSPLQEPERRMIQNPVKRDDILPDPSTLPNKFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZM9</accession>
    <name>A0A151NZM9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ACTR5</name>
        <name evidence="12" type="ORF">Y1Q_0002823</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZM9"/>
    <dbReference type="STRING" id="8496.A0A151NZM9"/>
    <dbReference type="eggNOG" id="KOG0681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033044">
        <property type="term" value="P:regulation of chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051052">
        <property type="term" value="P:regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000098">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000122">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000016">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000019">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO42203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="557" mass="64091" checksum="A0FC19EBA7A03F10" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZP4</accession>
    <name>A0A151NZP4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Spermatogenesis-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SPATA2</name>
        <name evidence="21" type="ORF">Y1Q_0002750</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts (via the PIM motif) with RNF31/HOIP (via the PUB domain); the interaction is direct. Interacts (via the PUB domain) with CYLD; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the SPATA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZP4"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990108">
        <property type="term" value="P:protein linear deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060544">
        <property type="term" value="P:regulation of necroptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010803">
        <property type="term" value="P:regulation of tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15074">
        <property type="entry name" value="7tmA_Opsin5_neuropsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000219">
        <property type="entry name" value="Opsin 5-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2190:FF:000002">
        <property type="entry name" value="spermatogenesis-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002962">
        <property type="entry name" value="Peropsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048839">
        <property type="entry name" value="SPATA2_PUB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15326:SF8">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15326">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 2/TAMOZHENNIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21388">
        <property type="entry name" value="SPATA2_PUB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01244">
        <property type="entry name" value="PEROPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="6" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="608"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="659"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="462"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="857" mass="97084" checksum="4FB6562B94EB0152" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1I8</accession>
    <name>A0A151P1I8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001351">
        <property type="protein sequence ID" value="KYO42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1I8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586577" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8691" checksum="6E58F203BAF41569" modified="2016-06-08" version="1">MQILSLSEVLWPCTLFLILAAVRFQEPPKHKEHCYLEARDLPNRGLYPFVQSLFCNVGSRCKNSSYSTPKNNSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P219</accession>
    <name>A0A151P219_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho guanine nucleotide exchange factor 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ARHGEF39</name>
        <name evidence="4" type="ORF">Y1Q_0023052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001354">
        <property type="protein sequence ID" value="KYO42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P219"/>
    <dbReference type="STRING" id="8496.A0A151P219"/>
    <dbReference type="eggNOG" id="ENOG502QTR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042987">
        <property type="entry name" value="ARHGEF39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47056">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47056:SF1">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="227"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="342" mass="39364" checksum="32580A6D52B3C6B0" modified="2016-06-08" version="1">MHLQPVATANTVEEQRARWERKRSRTARELVETEQRYLEQLDLVITYFVTILKAKGTLLPAVRAAIFGPLESIHLTSQTLLHHLERGCLGQGLDSFCRELELYGHYAENLEPARKALQEQVKKNKAFRRFKKLQESRPEFLGLQLEDLLPLPLQRLHQYKHLLRDLMENTSPDCAEFQQLARAVKSISKMSHWVRDTARSHENSLQLLRVQKLLKGRKVKVLAPGRWYVREGWLMVVPAKGEEVKRMMFFLFSDILIATKPCHPLHLLNSDKFACQAVYPLSQCTVDKVFGHTQGQGGLLSLCFPHKTLLLMSSDQEDINRWHLSLTTAIRQLSARPTNSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3I1</accession>
    <name>A0A151P3I1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetochore-associated NSL1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NSL1</name>
        <name evidence="2" type="ORF">Y1Q_0013636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3I1"/>
    <dbReference type="STRING" id="8496.A0A151P3I1"/>
    <dbReference type="eggNOG" id="ENOG502S001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO43627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="274" mass="30476" checksum="5E1D01ED5402F945" modified="2016-06-08" version="1">MAASPARPRTAEPCGGTQRPGPDLAPALADPRVRCYSKRWVREVLARCGPCVRALLPGAGAEESQPGDALWNFETAVQENITINGEPWQETSDEDELQSGSDIKILEDQFDELIVETASKRKQCPRKIVVHIIKTMKAEQEILKLYKPVVKPQEIRPEPSQADCMADLRQVTGVTSKQIGEAMKSLPALIERAEGFSQALALQPVLELCKLRQEVFAGCKAKEENKIQSLITEVEITPTETAAKKNSVLKRRRPSDAIQLARYPLRRKRNSLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3M7</accession>
    <name>A0A151P3M7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3M7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="83" mass="9121" checksum="2C1E199C2CB466E1" modified="2016-06-08" version="1">MHLLLPAEPDTSCPGTSLPPALSLLCLSLCTEEIIRSIGLVTRSTNIAYGLYKFCMPPMLPMNTQTIHTFFHKDIILVTIDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4W6</accession>
    <name>A0A151P4W6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ryanodine receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Skeletal muscle calcium release channel</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Skeletal muscle ryanodine receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Skeletal muscle-type ryanodine receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Type 1 ryanodine receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0000838</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotetramer. Can also form heterotetramers with RYR2. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Repeated very high-level exercise decreases interaction with PDE4D and protein phosphatase 1 (PP1). Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel activity. Interacts with S100A1. Interacts with FKBP1A; this stabilizes the closed conformation of the channel. Interacts with CACNA1S; interaction with CACNA1S is important for activation of the RYR1 channel. Interacts with CACNB1. Interacts with TRDN and ASPH; these interactions stimulate RYR1 channel activity. Interacts with SELENON. Interacts with scorpion calcins (AC P0DPT1; AC P0DM30; AC A0A1L4BJ42; AC P59868; AC P60254; AC B8QG00; AC L0GBR1; AC P60252; AC P60253).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000896">
        <property type="protein sequence ID" value="KYO44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P4W6"/>
    <dbReference type="eggNOG" id="KOG2243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23290">
        <property type="entry name" value="beta-trefoil_MIR_RyR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000019">
        <property type="entry name" value="Ryanodine receptor 1 (skeletal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000009">
        <property type="entry name" value="Ryanodine receptor 1 (skeletal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000001">
        <property type="entry name" value="Ryanodine receptor 2 (Cardiac)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000003">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
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        <property type="entry name" value="SPRY2_RyR"/>
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        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF10">
        <property type="entry name" value="RYANODINE RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="13" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIR" evidence="23">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="23">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="23">
        <location>
            <begin position="232"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="22">
        <location>
            <begin position="547"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="22">
        <location>
            <begin position="973"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="22">
        <location>
            <begin position="1310"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1295"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1813"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1295"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1320"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1819"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1836"/>
            <end position="1852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2254" mass="253244" checksum="65E57B6C4A8D70E3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5L4</accession>
    <name>A0A151P5L4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox protein Hox-B3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXB3</name>
        <name evidence="14" type="ORF">Y1Q_0012102</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019338138.1">
        <property type="nucleotide sequence ID" value="XM_019482593.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059583017.1">
        <property type="nucleotide sequence ID" value="XM_059727034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5L4"/>
    <dbReference type="STRING" id="8496.A0A151P5L4"/>
    <dbReference type="GeneID" id="102560582"/>
    <dbReference type="KEGG" id="amj:102560582"/>
    <dbReference type="CTD" id="3213"/>
    <dbReference type="eggNOG" id="KOG0489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000094">
        <property type="entry name" value="Homeobox protein Hox-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025281">
        <property type="entry name" value="DUF4074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF11">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13293">
        <property type="entry name" value="DUF4074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="215"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="353"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO44334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="399" mass="43446" checksum="330A369246B54533" modified="2016-06-08" version="1">MQKTTYYDSSTLFGGYTYQGANGFGYDGPQQPFQPSSHVENDYQRSACSLQSLGNAAPHAKSKDLNGSCMRPSLPQEHHQPPPVSPPPNSVTNSNSSNSNNQSGSSKTAPSKSSLSANASLTKQIFPWMKESRQNSKQKNSSPSTESCSGEKSPPGSSASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKSKGMGSSSGGPSPTGSPPQPMQSSAGFLNTLHTMPSNYDAPSPPSFNKPHQNAYAMSTNYQNPIKGCPSQQKYANTAPEYDPHVLQGNGGSYGTPSMQGSPVYVGGNYVDSMPASGPSLYGLNHLPHHQSASMDYNAAPQMPPSQHHGPCETHPTYTDLSTHHSSSQGRIQEAPKLTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7P8</accession>
    <name>A0A151P7P8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0007408</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cell membrane</location>
            <topology evidence="2 14">Lipid-anchor</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7P8"/>
    <dbReference type="STRING" id="8496.A0A151P7P8"/>
    <dbReference type="KEGG" id="amj:102573806"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000004">
        <property type="entry name" value="Phosphorylase b kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF4">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, SKELETAL MUSCLE ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 14" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="11 13 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 13 14" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="16">
        <location>
            <begin position="8"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="17">
        <location>
            <begin position="1065"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1018"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-farnesyl cysteine" evidence="13">
        <location>
            <position position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR608734-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO45117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1243" mass="139270" checksum="CFBF45B4C2C28991" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P853</accession>
    <name>A0A151P853_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sprouty-like protein 3 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPRY3</name>
        <name evidence="3" type="ORF">Y1Q_0007377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sprouty family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P853"/>
    <dbReference type="STRING" id="8496.A0A151P853"/>
    <dbReference type="GeneID" id="102558469"/>
    <dbReference type="KEGG" id="amj:102558469"/>
    <dbReference type="CTD" id="10251"/>
    <dbReference type="eggNOG" id="ENOG502R5TY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038884at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051192">
        <property type="entry name" value="Sprouty_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365:SF9">
        <property type="entry name" value="PROTEIN SPROUTY HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365">
        <property type="entry name" value="SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO45079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="305" mass="33702" checksum="BF97BBACE7B252A0" modified="2016-06-08" version="1">MQLSSSVAELSREQTMDPPAEDFQQVLSIDQIRSIRASNDYVERPAVSFMQARSNPSLPQNSHKTEWSQDHLVSSTFQDLHRSQSQHHQIPPLQPHLSHSSTASSMSRSTTASDQRLLSGITPSQSGHSIIRTPPRVADLKPEEPLKGVAEKPSLHSGHLFICEECGRCKCVHCTTARTLPSCWLCNQRCLCSPESLIDYGTCLCCVKGLFYHCSTDDEDTCADDPCSCGPGSCCARWAAMSFLSLLMPCLCCYFPTLGCLKLCQRGYDSLRRPGCRCQNHTNTVCRKISSSSGNPFPKTLDKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8T0</accession>
    <name>A0A151P8T0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">creatine kinase</fullName>
            <ecNumber evidence="2">2.7.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0015058</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>creatine + ATP = N-phosphocreatine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17157"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57947"/>
            <dbReference type="ChEBI" id="CHEBI:58092"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17158"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 11">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.2" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8T0"/>
    <dbReference type="STRING" id="8496.A0A151P8T0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00716">
        <property type="entry name" value="creatine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000026">
        <property type="entry name" value="Creatine kinase B-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000001">
        <property type="entry name" value="Creatine kinase M-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF23">
        <property type="entry name" value="CREATINE KINASE B-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="14">
        <location>
            <begin position="125"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="292"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="320"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO45380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="395" mass="44233" checksum="5DE1DB09865FD6E6" modified="2016-06-08" version="1">MPFSNSHNLLKMKYPAEDEFPDLSVHNNHMAKVLTPELYSKLRGKQTPSGFTLDDIIQTGVDNPGHPFIMTVGCVAGDEESYDVFKELFDPVIEDRHGGYKPSDEHKTDLNSDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLSVEALGSLDGDLKGKYYALKNMTDAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCSGLTQIETLFKTKNYEFMWSPHLGYILTCPSNLGTGLRAGVHIKLPNLGKHEKFGDILKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLVEMEKQLENGNKKAKATREGLTVDHSALSRWPCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAA8</accession>
    <name>A0A151PAA8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small integral membrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SMIM14</name>
        <name evidence="4" type="ORF">Y1Q_0021527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAA8"/>
    <dbReference type="STRING" id="8496.A0A151PAA8"/>
    <dbReference type="eggNOG" id="ENOG502S7T0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020309">
        <property type="entry name" value="Smim-14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11027">
        <property type="entry name" value="DUF2615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO45904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="155" mass="17031" checksum="633B486B02013534" modified="2016-06-08" version="1">MANGEGGCRRLLPGAELPPPRTSPRTREQRTSRLQPRGAPDQVFAIRFWLIHIIMAEGGFDPCECICTHEHAMRRLINLLRQSQSYCTDTECLQELPGPNSSGDNGISFAMIMMAWVAIALVLFLLRPSNLRGSNTVGKPTSPHSGQEPPAPPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBM7</accession>
    <name>A0A151PBM7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ETS translocation variant 4 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ETV4-1</name>
        <name evidence="10" type="ORF">Y1Q_0018291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBM7"/>
    <dbReference type="STRING" id="8496.A0A151PBM7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000121">
        <property type="entry name" value="ETS translocation variant 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006715">
        <property type="entry name" value="ETS_PEA3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF181">
        <property type="entry name" value="ETS TRANSLOCATION VARIANT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04621">
        <property type="entry name" value="ETS_PEA3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586871" evidence="8">
        <location>
            <begin position="19"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="9">
        <location>
            <begin position="290"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO46481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="432" mass="49131" checksum="4C7133290CD22273" modified="2016-06-08" version="1">MFTLVIATLPTMVFYVYLSGMDRAQVPDSDEQFVPDFHSENLAFHSPPAKVKKEPQSPSSDPALSCSHKQPFRYRNGEQCLYASAYDQTRQAGIKSPDPGTPIQSPLQHFPRQDRSFLSLQGPSRPTSSCGYLMEHSSIYQPPVEMCHSFPSSQSTGREAPVAYQRQMSEPCLQYPQQGFKQEYHDPTYEQANQMGGSGTCQYPAGLVIKQEQTDYAYDSDAGCPSMYMNTEGYRSHSHAEGPLGYGYDKKMRPFSEDVCVVPEKFEAGDIKQEVGGYREGPPYQRRGSLQLWQFLVALLDDPTNSHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPTLKAEFDRQVSEEDTVPLSHLDENAAYMQDLGSLPSQPYNKGYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCL1</accession>
    <name>A0A151PCL1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCL1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="8572" checksum="7560ABA02D69CE3D" modified="2016-06-08" version="1">MACLYSRFIFPQFSAARLSHSGFKSSLLLVPVPSSPLSHTCEQTANCLIDVSAPCAPACSSLLFSSLFRFEQPQQEGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDC2</accession>
    <name>A0A151PDC2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDC2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="129" mass="14826" checksum="EABB9F2BF9127D42" modified="2016-06-08" version="1">MAAELPLQLWQETADQSAVLLKQSFSSADVQPIHRGRQGTSNKTRKGKAAKSQHNVRIKETIRYSTNRWRNRYKGANKLFAQVFQKLTNIRAKNKNQDSCLLHIHDMDAGHLMRSSSILYVSSLFDVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE22</accession>
    <name>A0A151PE22_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein ABHD18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PE22"/>
    <dbReference type="STRING" id="8496.A0A151PE22"/>
    <dbReference type="eggNOG" id="KOG1551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56376" checksum="66E8FA122BB7F1CE" modified="2016-06-08" version="1">MCAGGGSASGKSPELLLEESKWLPIHFNVSSLLMGLSKLDVLYRRLLLTKLFIQGWGKPEDLKRIFEFRKIIGNREKCQKLVSRDYPVFIDKVEEQSDCKILNGHFISPLAHYIPGILPTESIIARFQFIMPKKWNGNYRPVCIHLAGTGDHYYWRRRTLMARPMIKEACIASLLLENPYYGYRKPKDQLRSCLKNVSDLFVMGGALVLESAALLHWLEREGYGPLGMTGISMGGHMASLAVTNWPKPLPLIPCLSWSTASGVFTTGVLSKAVNWRELDKQYYTQTVYEEEIIQMLEYCGTDSFKMGQDFVKNAPNSVDSLNHLDVSSQLFDLNATSESVPKEAIHCLSTSKSTVSASSERLLMQDAPKIQCINQTFSTSSRSSNYFPNQQEHQLYGKRNRDALQRESLRFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYVPRTGVRSLQEIWPGCEIRYLDGGHISAYLFKQGLFRQAIYDAFERFLQKYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFL0</accession>
    <name>A0A151PFL0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-related protein Rab-21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RAB21</name>
        <name evidence="13" type="ORF">Y1Q_0019840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273864.1">
        <property type="nucleotide sequence ID" value="XM_006273802.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFL0"/>
    <dbReference type="STRING" id="8496.A0A151PFL0"/>
    <dbReference type="GeneID" id="102572583"/>
    <dbReference type="KEGG" id="amj:102572583"/>
    <dbReference type="CTD" id="23011"/>
    <dbReference type="eggNOG" id="KOG0088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PFL0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04123">
        <property type="entry name" value="Rab21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000550">
        <property type="entry name" value="ras-related protein Rab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041833">
        <property type="entry name" value="Rab21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO47772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="217" mass="23921" checksum="E5E2F166B601BE5E" modified="2016-06-08" version="1">MAAAAPGGRSFSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSVQEAETYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERARGNGSSQSGTARRGVQIIDDEPQVQSSGGCCSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFR6</accession>
    <name>A0A151PFR6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HRAS-like suppressor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0014886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000414">
        <property type="protein sequence ID" value="KYO47848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFR6"/>
    <dbReference type="STRING" id="8496.A0A151PFR6"/>
    <dbReference type="eggNOG" id="ENOG502S0JN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PFR6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF31">
        <property type="entry name" value="PHOSPHOLIPASE A AND ACYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="6">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO47848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="169" mass="18468" checksum="4937CAB97877366E" modified="2016-06-08" version="1">MAGRAAGLQKEPKPGDLIQIFRSTYDHWAVYVGYGYVVHMAPQGQAAEAGFSSLFSVLTDKAVVRRDPLWIVTAADRYQVNNLHDTDMPARPREDIVRDAEAQVGQVLSYSITSQNCEHFVTQLRYGVPCSDQVRDAVTAGAAGVALLGVLGAGLFVGKMLLRSRKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHB6</accession>
    <name>A0A151PHB6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000227">
        <property type="protein sequence ID" value="KYO48294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHB6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8671" checksum="959321897CB241A7" modified="2016-06-08" version="1">MDLLCMWLSQKAMNSRSVTSIEVWRLWFRDVQWCRNLIQTLLIRYTRRECSKRTRSHFYPYCNSPSALKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ65</accession>
    <name>A0A151PJ65_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000111">
        <property type="protein sequence ID" value="KYO49070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ65"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO49070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="142" mass="15855" checksum="FE91BCDF119E3DCD" modified="2016-06-08" version="1">MPADYLHWQTSPAIPLLWDTSQHTSHLPDAEGWNRSPLKEQETSVSTQVRVRVSGISNLVSPVFAGSPFRSARFPLSWSWWKEGDSHTVSSSAHDALERYQQLETGGCVFFLRSEPGLPGISPAHFAFLHTPEISEKQKKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LY67</accession>
    <name>A0A151LY67_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4629 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0007677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007073">
        <property type="protein sequence ID" value="KYO17196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LY67"/>
    <dbReference type="KEGG" id="amj:102574798"/>
    <dbReference type="eggNOG" id="ENOG502SEP6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9418974at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040292">
        <property type="entry name" value="C2orf78-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027898">
        <property type="entry name" value="DUF4629"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31466">
        <property type="entry name" value="GENE 5591-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31466:SF1">
        <property type="entry name" value="RIKEN CDNA 4930433I11 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15442">
        <property type="entry name" value="DUF4629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4629" evidence="2">
        <location>
            <begin position="605"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO17196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="876" mass="94399" checksum="24FAD29AF7A2972C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYK2</accession>
    <name>A0A151LYK2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Taste receptor type 1 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TAS1R1</name>
        <name evidence="14" type="ORF">Y1Q_0011822</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007022">
        <property type="protein sequence ID" value="KYO17328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYK2"/>
    <dbReference type="STRING" id="8496.A0A151LYK2"/>
    <dbReference type="eggNOG" id="KOG1056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050917">
        <property type="term" value="P:sensory perception of umami taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15289">
        <property type="entry name" value="7tmC_TAS1R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF3">
        <property type="entry name" value="TASTE RECEPTOR TYPE 1 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00592">
        <property type="entry name" value="CASENSINGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="617"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO17328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="892" mass="99864" checksum="A63F85C413A19230" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYM4</accession>
    <name>A0A151LYM4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007022">
        <property type="protein sequence ID" value="KYO17356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYM4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO17356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="310" mass="34495" checksum="7CEEC50577783088" modified="2016-06-08" version="1">MDSGVLDTGPEIRKTQRTDSEDLVPGPESCKSCKMDSGDPDPGPKRLKTRRTDAGGLDRGPESQISRKKDSRDPDPHQESWEIQKTDFGGLDQGQENQKTPKTDSRGPDPGQDSWETWKMDSWGPDLGPESWKTQKTDSGGPDRGPESQKRWKMDSKGPDQGPKSRKTWKMGSEGRDRDPDSRRTRKMYSGDPDCGPGSQKTRKMDSGGPDRGPESRKTCNTESGVPDPGLETRKTRKTDSGRPDWGPESQKTQKMNSVETDLGQESWKMQKKDSGNPDQGPEIQKTQKTDSLGPDLCPESWKTQKTDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZX6</accession>
    <name>A0A151LZX6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0011472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZX6"/>
    <dbReference type="STRING" id="8496.A0A151LZX6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO17796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="204" mass="23537" checksum="76E02BA3D3515B81" modified="2016-06-08" version="1">MLVGVTEQLPYPVVLGCDWPELLGEITRARSKEKIEGFVVETEQVPPEEEARQEVDVTTLWEDEHFQLEQSREPDFRYALQEHLAQRDGEVLRSELMKTTSRFEGQIKTEIEMMLENGIICRSHSDWQSPIVAVPKPDGKIRLCVDFRKVNAVAKFNAYLMPRVDERIENIGQARYISTLDLMKGYWQVPVAPEDQEKTAFATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0D7</accession>
    <name>A0A151M0D7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Grancalcin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GCA</name>
        <name evidence="9" type="ORF">Y1Q_0011570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0D7"/>
    <dbReference type="STRING" id="8496.A0A151M0D7"/>
    <dbReference type="eggNOG" id="KOG0037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000087">
        <property type="entry name" value="Sorcin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735">
        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735:SF5">
        <property type="entry name" value="GRANCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO17936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="235" mass="26660" checksum="7679514F202EDCAD" modified="2016-06-08" version="1">MQNAKQNAFTCHALDPDTWCFPCQYGSYSGQMPRMQMAVRQPMPGAVPNMSYAGYSGYSAYSGTYSAAADPMWIYFTAVAGQDGEVDAEELQMCLMHSGISGTYSPFSLETCRIMISMLDRDYTGKMGFNEFKELWAALNAWKQNFMMIDQDRSGTVELHALTQVIAAMGYRLSPQTLAAIVKRYSKNGRIFFDDYVACCVKLRTLTDFFRRRDNMQQGFVNFVYDDFLQCTMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0V5</accession>
    <name>A0A151M0V5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="7">PARP</shortName>
            <ecNumber evidence="7">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PARP14</name>
        <name evidence="12" type="ORF">Y1Q_0011721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M0V5"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02903">
        <property type="entry name" value="Macro_BAL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12547">
        <property type="entry name" value="RRM1_2_PAR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000008">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034464">
        <property type="entry name" value="PAR10_RRM1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057044">
        <property type="entry name" value="PARP14_KH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057043">
        <property type="entry name" value="PARP14_KH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057045">
        <property type="entry name" value="PARP14_KH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057046">
        <property type="entry name" value="PARP14_KH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057049">
        <property type="entry name" value="PARP14_KH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054596">
        <property type="entry name" value="PARP14_WWE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057050">
        <property type="entry name" value="RRM_PARP14_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF89">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23084">
        <property type="entry name" value="KH_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23248">
        <property type="entry name" value="KH_PARP14_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23249">
        <property type="entry name" value="KH_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23251">
        <property type="entry name" value="KH_PARP14_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23254">
        <property type="entry name" value="KH_PARP14_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23245">
        <property type="entry name" value="RRM_PARP14_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22005">
        <property type="entry name" value="WWE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="11">
        <location>
            <begin position="801"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="9">
        <location>
            <begin position="1332"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO18145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1614" mass="180410" checksum="B0F37D2B0A4DDE05" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0X3</accession>
    <name>A0A151M0X3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorting nexin-4 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SNX4</name>
        <name evidence="5" type="ORF">Y1Q_0011727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0X3"/>
    <dbReference type="STRING" id="8496.A0A151M0X3"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07622">
        <property type="entry name" value="BAR_SNX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06864">
        <property type="entry name" value="PX_SNX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000035">
        <property type="entry name" value="Sorting nexin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034902">
        <property type="entry name" value="PX_SNX4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034783">
        <property type="entry name" value="SNX4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037430">
        <property type="entry name" value="SNX4_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46596">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46596:SF1">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="41"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO18153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="423" mass="49074" checksum="A90E26CA6A1BFEE6" modified="2016-06-08" version="1">MERSREDGPEPPPLPPEEPAAEQRGRAAAMEDCLLKKIEISVSEAEKRTGRNAVNMQETYTAYLIETRAVESQTEGQCSPVDSLWRRYSEFELLRNYLLVTFPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRVASHPILCQDKIFYSFLTQEGGWKEMVNETGFQLKQSHVKVKNPDKRFTELKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYSSSIDDILEEEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLTSKKQQCEELATGTVRTFSLKGMTSKLFGQETPEQREAKIKVLEEQIHEGEEQLKSKNLEGRDFVKTAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2B5</accession>
    <name>A0A151M2B5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL18m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L18, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPL18</name>
        <name evidence="10" type="ORF">Y1Q_0009121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263654.1">
        <property type="nucleotide sequence ID" value="XM_006263592.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2B5"/>
    <dbReference type="STRING" id="8496.A0A151M2B5"/>
    <dbReference type="GeneID" id="102564584"/>
    <dbReference type="KEGG" id="amj:102564584"/>
    <dbReference type="CTD" id="29074"/>
    <dbReference type="eggNOG" id="KOG3333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1932324at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M2B5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000005">
        <property type="entry name" value="39S ribosomal protein L18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584684" description="Large ribosomal subunit protein uL18m" evidence="9">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO18663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="188" mass="21461" checksum="2FF5877BF5A8E359" modified="2016-06-08" version="1">MALRSRVRSLLLSVAAAARLRGASEGLRFTSAKASFEVAGAEADTSENEVVAPDFANRNPRNLEQLALARKERGWETTWPSREFWRRLRFERTQQYVEAFVEDPRGNIVVSASTQEWAIKRHLYSPKGVVACKNIGRVLAQRCLEAGINFVEFKAVVPWERHYDSFQSFEKAMTDGGVVLREPRRIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2T0</accession>
    <name>A0A151M2T0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">ERO1-like protein beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Y1Q_0009247</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2T0"/>
    <dbReference type="STRING" id="8496.A0A151M2T0"/>
    <dbReference type="eggNOG" id="KOG2608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF2">
        <property type="entry name" value="ERO1-LIKE PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584696" description="ERO1-like protein beta" evidence="18">
        <location>
            <begin position="27"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="17">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="17">
        <location>
            <begin position="386"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO18835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53942" checksum="85C58097272805CF" modified="2016-06-08" version="1">MSGYWGPAAGPGLLAALSCLWAAGQAQLIGVLDDCQCDIESIDDFNTYKIFPKIQKLQERDYFRYYKVNLKRPCPFWADDGHCSIKDCHVEPCPESKVPIGIKAGSANKYSKAANNTKELEDCEQANKLGAVNSTLSNQSKEAFIDWARYDDSQDHFCELDDERSPDAQYVDLLLNPERYTGYKGPSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDDGEGFYTWLEGLCLEKRVFYKLISGLHASINLHLCAKYLLEETWGKPSWGPNVKEFVRRFDSIETKGEGLRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNVNEDAESKALLLDIFRDTKSFTMHFDEKSMFAGDKKGAKSLKEEFRLHFKNISRIMDCVGCDKCRLWGKLQTQGLGTALKILFSEREIQNLPENSPSKGFQLTRQEIVALVNAFGRLSTSIKELQNFKVLLQHTRKKKLFSVVLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M304</accession>
    <name>A0A151M304_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NUS1</name>
        <name evidence="14" type="ORF">Y1Q_0018884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M304"/>
    <dbReference type="STRING" id="8496.A0A151M304"/>
    <dbReference type="eggNOG" id="KOG2818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584712" description="ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]" evidence="13">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO18905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="177" mass="20154" checksum="EA9792DF438689E0" modified="2016-06-08" version="1">MASLVVWCMALGISYVSVYDHDGIFKRNNSKLMDEILKQQQELLGLDYSKYKMEFANQDKADQVLNCQSALKVLSPEDGKADIVRAAQNFCQLVAQQQRKYTDLDVNVLDNLLSSTNGFPDPDLILKFGPVDSTLGFLPWHIRLTEIISLPSHLNINYEDFFSALLRYAACEQRWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M396</accession>
    <name>A0A151M396_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM244</name>
        <name evidence="7" type="ORF">Y1Q_0018950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M396"/>
    <dbReference type="STRING" id="8496.A0A151M396"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO18997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="175" mass="19317" checksum="35583AC02639FE6D" modified="2016-06-08" version="1">MSPNLWASSISGGGSGGSSSGGMSSSGGMNSSGRAVLLNLLICTIVFYTVYYVVLSICFAAFRLKMLDGWAPFDFKTNPSWINPNYLVLLVSLEITYFICGLLFALVVEEWVWDYAITVTVIHIIITSFVMSEFPLMLHWWLALGAGLISMICGGEILAYCLFKDNFIYPILDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3N3</accession>
    <name>A0A151M3N3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="19">PARP</shortName>
            <ecNumber evidence="19">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PARP2</name>
        <name evidence="25" type="ORF">Y1Q_0005024</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3. Homo- and heterodimer with PARP1. Interacts (via the PARP catalytic domain) with HPF1. Interacts with core nucleosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03006740">
        <property type="protein sequence ID" value="KYO19127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266632.2">
        <property type="nucleotide sequence ID" value="XM_006266570.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019334998.1">
        <property type="nucleotide sequence ID" value="XM_019479453.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3N3"/>
    <dbReference type="STRING" id="8496.A0A151M3N3"/>
    <dbReference type="GeneID" id="102561318"/>
    <dbReference type="KEGG" id="amj:102561318"/>
    <dbReference type="CTD" id="10038"/>
    <dbReference type="eggNOG" id="KOG1037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08003">
        <property type="entry name" value="WGR_PARP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000003">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 19" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WWE" evidence="21">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="24">
        <location>
            <begin position="227"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="23">
        <location>
            <begin position="352"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="22">
        <location>
            <begin position="477"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO19127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="702" mass="79229" checksum="76C34D18312A95FA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5N9</accession>
    <name>A0A151M5N9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0006804</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006526">
        <property type="protein sequence ID" value="KYO19836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5N9"/>
    <dbReference type="eggNOG" id="ENOG502SI2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15947">
        <property type="entry name" value="7tmA_OR2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000005">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO19836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="276" mass="30877" checksum="4D32EC35A6281CF1" modified="2016-06-08" version="1">MLVNLAIIVVSQLDPSLNTPMYFFLSNLSILDLCYTTSTVPQMLVNFRSAHKFISWAGCVAQLFIFLSLGSTECLLLAVMAYDRYAAVCQPLHYTTIMSPRLCWVMAGGSWLSGITNSIVQTSLTLQLPLCGRNRVDHFFCEVPALLRLACADIFINEAELFAISVLFLLVPLGLVLVSYGYIGAAVLRIQSAEGRRKAFNTCASHLIVVSLFYGTAIYMYLQPPSHHSQNHGKMVSLFYGIITPMLNPVIYTLRNKDVHGALRKTLGRWRWKQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M689</accession>
    <name>A0A151M689_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0024445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006442">
        <property type="protein sequence ID" value="KYO20018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M689"/>
    <dbReference type="STRING" id="8496.A0A151M689"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO20018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="124" mass="14123" checksum="ED8F43B864218267" modified="2016-06-08" version="1">MQLLAPFCPCTARNTLTQPNVWLAIFLSIILCVLPVVGYRFLKVQLKPTVSDKVVQKIKEYKKRPLPPSPKRRLRRTSTRRSGYAFSHQHGFGALIMSGRNMRPKSPFGVTGTFSPNSEKNRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6S1</accession>
    <name>A0A151M6S1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SFXN1</name>
        <name evidence="15" type="ORF">Y1Q_0010764</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alanine(in) = L-alanine(out)</text>
            <dbReference type="Rhea" id="RHEA:70719"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine(in) = L-cysteine(out)</text>
            <dbReference type="Rhea" id="RHEA:29655"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-serine(in) = L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:35031"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6S1"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF8">
        <property type="entry name" value="SIDEROFLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO20199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="381" mass="41823" checksum="9BD32B409E7076EA" modified="2016-06-08" version="1">MNGTCPQRLEWHCCTVGTGSGELPQTPLALSAVGGSSGGRWERGSGGVVRRSSGREFKKMSSTIPLNINIKEPRWDQSTFVGRASHFFTVTDPRNILLSNTQLENARKIIHDYRQGVVAPELTEDELWRAKYVYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVVFWQWINQSFNAIVNYTNRSGDAPITVSQLGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKYGIPVTDENGNRLGESTKAAQQAITQVVISRILMAAPGMAIPPFIMNALEKRAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTRLEPELKAKIQEISPDLGRVYFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6Y5</accession>
    <name>A0A151M6Y5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Folliculin-interacting protein 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FNIP2</name>
        <name evidence="9" type="ORF">Y1Q_0010812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FNIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6Y5"/>
    <dbReference type="STRING" id="8496.A0A151M6Y5"/>
    <dbReference type="GeneID" id="102558427"/>
    <dbReference type="KEGG" id="amj:102558427"/>
    <dbReference type="CTD" id="96459"/>
    <dbReference type="OrthoDB" id="10051712at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028086">
        <property type="entry name" value="FNIP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026156">
        <property type="entry name" value="FNIP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028085">
        <property type="entry name" value="FNIP_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF12">
        <property type="entry name" value="FOLLICULIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14638">
        <property type="entry name" value="FNIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14637">
        <property type="entry name" value="FNIP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02073">
        <property type="entry name" value="FOLLICULNIP1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FNIP1/2-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="937"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO20267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1174" mass="130592" checksum="91255E7E0263AA3A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9P4</accession>
    <name>A0A151M9P4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9P4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="8070" checksum="95E468C819860A22" modified="2016-06-08" version="1">MPTRDDVRLTTVPVSISFIWDPWLCERVFIHFLLLWALRRPHFWSSLDIVCSVLRPPLFPLLQHQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAH0</accession>
    <name>A0A151MAH0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAH0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="11452" checksum="598BE340FEA60DF8" modified="2016-06-08" version="1">MAKAQTGVSGEGGRQRSGKSEGSWLRQGHLGTRGGPGHCVRRAGQAAAGHRARPAPEPGGGQDCSERRNLSEGDSYMLPSGYLTWHKPTSSPGSVVPGGTKGAMDQNARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB15</accession>
    <name>A0A151MB15_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle transport through interaction with t-SNAREs-like protein 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">VTI1B</name>
        <name evidence="12" type="ORF">Y1Q_0000425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266496.1">
        <property type="nucleotide sequence ID" value="XM_006266434.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MB15"/>
    <dbReference type="STRING" id="8496.A0A151MB15"/>
    <dbReference type="GeneID" id="102567526"/>
    <dbReference type="KEGG" id="amj:102567526"/>
    <dbReference type="CTD" id="10490"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MB15"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15890">
        <property type="entry name" value="SNARE_Vti1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF89">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="131"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO21704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="232" mass="26967" checksum="31A6AD37EA64B1CB" modified="2016-06-08" version="1">MAVRGPGSSEHLERLHEIFRELHGQLRVLPERLRGGLAEEKKKLIREFDEKQQEANETLREMEEELKHAPLPFRNQMMSKIRAYKRDLSMFQREMRSTDLGLVPGNRGDTKYGIYSMENEQSTQLQSQRVLVLQGTDSLNRATQSIERSHQISAETDQIGTNIIEELGEQREQLERTRGRLVNTNENLSKSRKILRSMSRRVTTNKLLLSVIIILELAILGGVVYYKFFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBC8</accession>
    <name>A0A151MBC8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBC8"/>
    <dbReference type="KEGG" id="amj:102558903"/>
    <dbReference type="eggNOG" id="ENOG502S2E8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6156669at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MBC8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031521">
        <property type="entry name" value="DUF4695"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40250">
        <property type="entry name" value="CHROMOSOME 11 OPEN READING FRAME 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40250:SF1">
        <property type="entry name" value="SI:CH1073-281M9.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15766">
        <property type="entry name" value="DUF4695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="13906" checksum="A98C27B60F136373" modified="2016-06-08" version="1">MMAAAKPAELLGICSSYQAVMPHLVCLAEAFPPPVRPAKPPAAKGKQRRSRQSRFKTQPVTFDEIQEVEEEGVSPVEEERAKKSFLQSLECLRRSTQNLSLVQRDKLGSCCKLRSSLDSSDSDSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBI8</accession>
    <name>A0A151MBI8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="7973" checksum="B688D4362168DE8A" modified="2016-06-08" version="1">MESXXXSQQAFKVADQVSGSRSFPCRCKAPRLSVAARKGDPFVHGLSLQPVARFEENGGPACCKEVQTSETVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCB1</accession>
    <name>A0A151MCB1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor-type tyrosine-protein phosphatase eta</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein-tyrosine phosphatase receptor type J</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PTPRJ</name>
        <name evidence="25" type="ORF">Y1Q_0000733</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCB1"/>
    <dbReference type="STRING" id="8496.A0A151MCB1"/>
    <dbReference type="eggNOG" id="KOG0791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14615">
        <property type="entry name" value="R-PTPc-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000009">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000362">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase eta"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF5">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="25" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="123"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="212"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="301"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="392"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="483"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="22">
        <location>
            <begin position="891"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="23">
        <location>
            <begin position="1066"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO22132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1187" mass="132030" checksum="DFC99C03F45BF489" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCG5</accession>
    <name>A0A151MCG5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCG5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="8248" checksum="1C548BE808BC2330" modified="2016-06-08" version="1">MCHQTFSSGIPVPLVELFIQCKNFVMIFLGCGSFPVSLAVGLKLDELHLFWNTCYLEEEITVPQKSHILDMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MD32</accession>
    <name>A0A151MD32_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MD32"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7180" checksum="BC60E46C6886BBC9" modified="2016-06-08" version="1">MQKHWHIAKPCMLYTGLQPLVQPALKGFPHNHTSAGISDFFSISAVLAIDQMASFAFVGVATPGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MET4</accession>
    <name>A0A151MET4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taperin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TPRN</name>
        <name evidence="3" type="ORF">Y1Q_0005501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MET4"/>
    <dbReference type="STRING" id="8496.A0A151MET4"/>
    <dbReference type="GeneID" id="102570798"/>
    <dbReference type="KEGG" id="amj:102570798"/>
    <dbReference type="CTD" id="286262"/>
    <dbReference type="eggNOG" id="ENOG502RHCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9945184at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MET4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025907">
        <property type="entry name" value="Phostensin/Taperin_PP1-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026671">
        <property type="entry name" value="PPP1R18/Tprn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21685:SF1">
        <property type="entry name" value="TAPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21685">
        <property type="entry name" value="TON-B BOX DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13914">
        <property type="entry name" value="Phostensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phostensin/Taperin PP1-binding" evidence="2">
        <location>
            <begin position="188"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO23011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="420" mass="45296" checksum="AAA5588CD63FA502" modified="2016-06-08" version="1">MQRPKPEGAEGTQSTRPCASLAPSSATPGALQPLSASAPKASSGSFEIRPSPKPDLAAIPAHDLQAQALANLRLNSRNSFLVVPSRAKAPCPPAPAESLRTGIPLSSEPERGQQEEPSPAAFEAQREPVTPPKASPEPLVPVTYIDDDIVEPEPGDLASVPGAAAETKDLLVPRDAASGMGTEMEVSAVPFYQPHPASPGFAQRGGYTFTVVPKRKPPVSGLATFTDGSRVQQNEGVEDEEIRGRPKPCRSADASSPGPLLKTRYPKAHEIEVIGGYLSLERSCISKKGSRRKKMKISFNEMSLQTMFEYPSESSLAEEDEEEEEEEEFSSEMEDDKPSSFFIPHPNSTLHPNVPNPGLSSYTPKHSVEFGKWQEQKYEDQPGAMGTVPKEVDTLGNQVMLTPADRSCLSDFSSEPALYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEX2</accession>
    <name>A0A151MEX2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING finger protein 183-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0005525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEX2"/>
    <dbReference type="KEGG" id="amj:102561171"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF30">
        <property type="entry name" value="RING FINGER PROTEIN 223-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO23055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="214" mass="23873" checksum="398E06DA8496F529" modified="2016-06-08" version="1">MLAPLQGPAALDSQEELALEMECAICYSQYNNAFHAPKVLQCQHTFCLECLARINVKSQLPDTIQCPMCRSYTRLPDSGPPKLDNNLAILSCLPKGMNRTCSIHFSRSKGRLWLKQLPEVSHGTVVPQIFMSNISHSLDVGRPPWQENQLHQEDQWSRWSCLDKPLCRTLLVVAVMVTVTLIISSTLFFILPPSSRASHNMTALSPLVATDSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGD8</accession>
    <name>A0A151MGD8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cationic amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC7A14</name>
        <name evidence="12" type="ORF">Y1Q_0015353</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006193">
        <property type="protein sequence ID" value="KYO23571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267780.1">
        <property type="nucleotide sequence ID" value="XM_006267718.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGD8"/>
    <dbReference type="STRING" id="8496.A0A151MGD8"/>
    <dbReference type="GeneID" id="102563359"/>
    <dbReference type="KEGG" id="amj:102563359"/>
    <dbReference type="CTD" id="57709"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000024">
        <property type="entry name" value="High affinity cationic amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF17">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="11">
        <location>
            <begin position="627"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO23571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="770" mass="84255" checksum="47FBBBAA5183C1EB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGP0</accession>
    <name>A0A151MGP0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGP0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="171" mass="18213" checksum="22E48397F253A06A" modified="2016-06-08" version="1">MNGPPKAKGRQLEQQPCPQLTPLRSGTAACAGGAAAPSLAAGFSALCPQPSLAPSLLSLQVQKLTTSGSTSRQTVSDLFHLCLAARVAGDQTQKLARDDRINLTAKKIGFHLMHIQQVSLLDQSSSSGSCSEFKGYKGLALLDTWSRISDNCKRLMEPFYSILMVGKSVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MH21</accession>
    <name>A0A151MH21_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MH21"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO23822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="176" mass="20139" checksum="00550D9672276B75" modified="2016-06-08" version="1">MATGMRLELPPHMATKASTQFTSARQPWRLDYNRHSCCFSAREPAPDWSMAQWSHGEKWPGGQEHSRKCLGARTGTRCAPCHWEHTVTAAYANSIFSLSGWDIREEESYRRRTKEGAPETLAAWFILASRGRLKNQNNSKLGSRGTLQKRYQTEETKTRDTVSPAYYSLQVLIDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MH72</accession>
    <name>A0A151MH72_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein MEMO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mediator of ErbB2-driven cell motility 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MEMO1</name>
        <name evidence="4" type="ORF">Y1Q_0015849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270083.1">
        <property type="nucleotide sequence ID" value="XM_006270021.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MH72"/>
    <dbReference type="STRING" id="8496.A0A151MH72"/>
    <dbReference type="GeneID" id="102572872"/>
    <dbReference type="KEGG" id="amj:102572872"/>
    <dbReference type="CTD" id="51072"/>
    <dbReference type="eggNOG" id="KOG3086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.830.10:FF:000002">
        <property type="entry name" value="MEMO1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO23864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="297" mass="33775" checksum="A08314EB49D71F31" modified="2016-06-08" version="1">MSNRVLCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPNITRKIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIVPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAINELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJZ6</accession>
    <name>A0A151MJZ6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lysophospholipid acyltransferase LPCAT4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LPCAT4</name>
        <name evidence="13" type="ORF">Y1Q_0014080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006003">
        <property type="protein sequence ID" value="KYO24783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJZ6"/>
    <dbReference type="STRING" id="8496.A0A151MJZ6"/>
    <dbReference type="eggNOG" id="KOG4666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15937">
        <property type="entry name" value="7tmA_OR4N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000007">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050427">
        <property type="entry name" value="Olfactory_Receptors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48002">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="10"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO24783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="763" mass="84962" checksum="7962B4113BB694F2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK42</accession>
    <name>A0A151MK42_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SEC13 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">GATOR2 complex protein SEC13</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">SEC13-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SEC13</name>
        <name evidence="20" type="ORF">Y1Q_0023766</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. At the COPII coat complex: interacts with SEC31A and SEC31B. Interacts with SEC16A. Interacts with SEC16B. Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014460978.1">
        <property type="nucleotide sequence ID" value="XM_014605492.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK42"/>
    <dbReference type="STRING" id="8496.A0A151MK42"/>
    <dbReference type="GeneID" id="102560870"/>
    <dbReference type="KEGG" id="amj:102560870"/>
    <dbReference type="CTD" id="6396"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 19" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO24894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="320" mass="35255" checksum="961FCD53F03F84AA" modified="2016-06-08" version="1">MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTYEYTGHDSSVNSVCWAPHDYGLILACGSSDGAISLLGYTGDGQWEVKKISNAHTIGCNAVSWAPAVVPGSLIEQPSGQKPNYIKRFASGGCDNLVKIWKEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTMASCSQDGRVFIWTCDDASGNSWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGLWVCISDVNKGQGAVSAITEGQQNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKL5</accession>
    <name>A0A151MKL5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Crescent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0023885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO25057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKL5"/>
    <dbReference type="STRING" id="8496.A0A151MKL5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03580">
        <property type="entry name" value="NTR_Sfrp1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000001">
        <property type="entry name" value="secreted frizzled-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF133">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="FZ" evidence="10">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="11">
        <location>
            <begin position="124"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO25057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="251" mass="28328" checksum="E8949DABE8A07DD8" modified="2016-06-08" version="1">MALCYGLGYTDMRLPNLLEHETVAEATQQASSWLPLLARECHPDARILLCSLLAPVCLDSFIYPCRSLCEAVRSSCAPIMECYGYPWPEILNCAKFPADHNLCIAAVTPEETAASRRAVPRASCNDCELQEAGTTREVLEGFCASDFTAKIRISRRNATSTLAGFSLDTRLEMLKHGPLLWADTYPKLQQWLDLDATCVHNIMRGTQAGVYIVSGTMHQGRLVVNKAYDWHRRNRALQLAVRRWKQHRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLG9</accession>
    <name>A0A151MLG9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 protein epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">YWHAE</name>
        <name evidence="7" type="ORF">Y1Q_0021957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005807">
        <property type="protein sequence ID" value="KYO25372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259463.1">
        <property type="nucleotide sequence ID" value="XM_006259401.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLG9"/>
    <dbReference type="SMR" id="A0A151MLG9"/>
    <dbReference type="STRING" id="8496.A0A151MLG9"/>
    <dbReference type="GeneID" id="102558685"/>
    <dbReference type="KEGG" id="amj:102558685"/>
    <dbReference type="CTD" id="7531"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10020">
        <property type="entry name" value="14-3-3_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="6">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO25372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="255" mass="29174" checksum="07817CCBD1F75B26" modified="2016-06-08" version="1">MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMD8</accession>
    <name>A0A151MMD8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Butyrophilin subfamily 1 member A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005753">
        <property type="protein sequence ID" value="KYO25560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMD8"/>
    <dbReference type="STRING" id="8496.A0A151MMD8"/>
    <dbReference type="KEGG" id="amj:106737750"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12888">
        <property type="entry name" value="SPRY_PRY_TRIM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="46"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="239" mass="26572" checksum="6612FBEE9E0D6D50" modified="2016-06-08" version="1">MGVIRQCPVAGMKVHSPVSCCTCMELFPRRSTSCVPQDWLPCPAPMDSTAPPAYPKMKVYRDKEDVTLDPDTAHASLVLSVNRRSVTATDTPQSLPNSPGRFNVYSCVLGTDGYMSGTHYWDVEVGDKQGWALGVTRESANRRGWFDFSPEQGTWAIQLSMDQYRAVNAEWSLLDLPQRPRKIRVYLDCDSGVVGFYDADTMAPIHAFTASFSGKVCPFFWVWSVGTSLNLCPPQPTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN18</accession>
    <name>A0A151MN18_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger C2HC domain-containing protein 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZC2HC1A-1</name>
        <name evidence="10" type="ORF">Y1Q_0003724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZC2HC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN18"/>
    <dbReference type="STRING" id="8496.A0A151MN18"/>
    <dbReference type="GeneID" id="102563562"/>
    <dbReference type="KEGG" id="amj:102563562"/>
    <dbReference type="CTD" id="51101"/>
    <dbReference type="eggNOG" id="KOG3940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10066537at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MN18"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF25">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="9">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO25937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="373" mass="40544" checksum="F3CCFD5A9D8F7653" modified="2016-06-08" version="1">MEGLEENEPTVQSGDLLPCKICGRTFFLLALKKHAPICQKTSSKRRKTFDSSRQRAEGTDISTVKPLKPRPEPPKKQSNWRRKHEEFIATIRAAKGLNFKDGGKLPPPPPPSYDPDYIQCPYCQRRFNENAADRHISFCKEQAARITNKGKVCSDVKGKLPTRTQYKPAAIKKATSVTSAPSVSSRLPQPSSVSKTVAATPASKGLSSPGSTGSKIQTLSPAHKNSLGVTNSQGSKMDKLGPPLRTGRDVQRLYDSDTKTDSTIKRPNELLPINKGTVKTRTSTPPSLARSAGTAALASKRKTYSAESYSSRSDGKLGYDSGDCSSSVNGGSSRSSEGNSPVQLSKFCHECGTRYPVDWAKFCCECGIRRMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNZ6</accession>
    <name>A0A151MNZ6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tumor necrosis factor receptor superfamily member 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TNFRSF25</name>
        <name evidence="9" type="ORF">Y1Q_0005965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005615">
        <property type="protein sequence ID" value="KYO26258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019353969.1">
        <property type="nucleotide sequence ID" value="XM_019498424.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNZ6"/>
    <dbReference type="STRING" id="8496.A0A151MNZ6"/>
    <dbReference type="GeneID" id="102576976"/>
    <dbReference type="KEGG" id="amj:102576976"/>
    <dbReference type="CTD" id="8718"/>
    <dbReference type="eggNOG" id="ENOG502S19V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9940478at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022329">
        <property type="entry name" value="TNFR_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47220">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47220:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="repeat" description="TNFR-Cys" evidence="6">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="8">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="6">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="8">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="7">
        <location>
            <begin position="260"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO26258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="345" mass="38203" checksum="8CC76E0B7328D08D" modified="2016-06-08" version="1">MCPPGTFMESPCAYAGEEPTCRHCPTGTFLSACNTMLECLACSECDAQVSEVVLKNCTATSNVECGCRPGYFQRCNQPSCKDFTCTQCRQCRGRSTRRNCSSREDTQCGDCKPGFFLEGSECQPCASKGLEWCGDSCEKTCGSPNLPAGTGLEYLLLCLIGPLLLGALVAYHKRRQLSQDTLSTADEVAIRDLMLQKAEPCLPDATAPSLESQNLLQLNLTESLQMNGAAWAATASCSLSSKEPHQDAPSPPRGSVLQPGSQLYDIIDAVPVRRWKEFMRVLELRDAEIEVVEMEFTHVRDQQYEMLKRWCQQRHATLNAVIHALERMELSGCAEELRHRLQCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQ28</accession>
    <name>A0A151MQ28_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQ28"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7699" checksum="E28C72C25D692790" modified="2016-06-08" version="1">MGLTANTVQAEDMFGERVTCYLQSKAERQGKPYRFLPFTSYPKERKGRNSHLLLVGPLVVSYWNCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQB5</accession>
    <name>A0A151MQB5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD finger protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PHF14</name>
        <name evidence="14" type="ORF">Y1Q_0019190</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQB5"/>
    <dbReference type="STRING" id="8496.A0A151MQB5"/>
    <dbReference type="eggNOG" id="KOG0957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15674">
        <property type="entry name" value="ePHD_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15561">
        <property type="entry name" value="PHD1_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15562">
        <property type="entry name" value="PHD2_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15563">
        <property type="entry name" value="PHD3_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000059">
        <property type="entry name" value="PHD finger protein 14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000086">
        <property type="entry name" value="PHD finger protein 14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF150">
        <property type="entry name" value="PHD FINGER PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="215"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="278"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="621"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="764"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="816"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="526"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO26721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="882" mass="99098" checksum="33D53F74B4912DB4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQV7</accession>
    <name>A0A151MQV7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQV7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9625" checksum="9BA90CB245BBB7C8" modified="2016-06-08" version="1">MHQSFPAIIEMYEYGQIYEFKKRGSGDATTAPGADCTRHQVLRTFLAYMKQLQADVPAPFGVFPRIRLPVPSKIKEAQVTSSRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR05</accession>
    <name>A0A151MR05_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CKLF-like MARVEL transmembrane domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CMTM6</name>
        <name evidence="9" type="ORF">Y1Q_0019377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267342.1">
        <property type="nucleotide sequence ID" value="XM_006267280.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR05"/>
    <dbReference type="STRING" id="8496.A0A151MR05"/>
    <dbReference type="GeneID" id="102571801"/>
    <dbReference type="KEGG" id="amj:102571801"/>
    <dbReference type="CTD" id="54918"/>
    <dbReference type="eggNOG" id="KOG4788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MR05"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF25">
        <property type="entry name" value="CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="25"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO26967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="180" mass="20010" checksum="732A3E1F41E4F929" modified="2016-06-08" version="1">MDNGAVYEQTTEPHDARARLCGAPRLDLPRLVLKALQLLFSFVAFICEEVVESCTLCGGLYFFEFVSCSALLLSLLLLVVYCTTLYERFGDDSIRKTDFVATTIVSGFFILASIVFAATNDESSVETLAIVFGFLASLAFLGDLIYMLMKRRKPANEKKAENPDRQETPENQPLKSEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRB6</accession>
    <name>A0A151MRB6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polycomb group protein ASXL2 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ASXL2-1</name>
        <name evidence="13" type="ORF">Y1Q_0008892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asx family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005400">
        <property type="protein sequence ID" value="KYO27075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRB6"/>
    <dbReference type="STRING" id="8496.A0A151MRB6"/>
    <dbReference type="eggNOG" id="ENOG502QWPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035517">
        <property type="term" value="C:PR-DUB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042975">
        <property type="term" value="F:peroxisome proliferator activated receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026905">
        <property type="entry name" value="ASX-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF11">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN ASXL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13922">
        <property type="entry name" value="PHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="11">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="12">
        <location>
            <begin position="294"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="399"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="686"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="851"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO27075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1144" mass="123824" checksum="F52D430E83973828" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSN2</accession>
    <name>A0A151MSN2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hydrocephalus-inducing protein-like protein isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HYDIN</name>
        <name evidence="10" type="ORF">Y1Q_0003668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033305">
        <property type="entry name" value="Hydin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033768">
        <property type="entry name" value="Hydin_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058536">
        <property type="entry name" value="Ig_CFAP65_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF012200">
        <property type="entry name" value="choice_anch_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053">
        <property type="entry name" value="DLEC1 DELETED IN LUNG AND ESOPHAGEAL CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053:SF0">
        <property type="entry name" value="HYDROCEPHALUS-INDUCING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17213">
        <property type="entry name" value="Hydin_ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24507">
        <property type="entry name" value="Ig_CFAP65_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="8">
        <location>
            <begin position="236"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="8">
        <location>
            <begin position="496"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Hydin adenylate kinase-like" evidence="7">
        <location>
            <begin position="2063"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 fourth Ig-like" evidence="9">
        <location>
            <begin position="4595"/>
            <end position="4687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1283"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1540"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1997"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2153"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2383"/>
            <end position="2498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2535"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2705"/>
            <end position="2782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3895"/>
            <end position="3921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1540"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2004"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2158"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2194"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2383"/>
            <end position="2399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2407"/>
            <end position="2418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2419"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2437"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2540"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2559"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2738"/>
            <end position="2752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2759"/>
            <end position="2772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2773"/>
            <end position="2782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="3900"/>
            <end position="3909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO27513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="5184" mass="581053" checksum="CF4F31FC7715A296" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSX7</accession>
    <name>A0A151MSX7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sphingomyelin synthase-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SAMD8</name>
        <name evidence="12" type="ORF">Y1Q_0005182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:36079"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:73203"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:36080"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSX7"/>
    <dbReference type="STRING" id="8496.A0A151MSX7"/>
    <dbReference type="eggNOG" id="KOG3058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="11">
        <location>
            <begin position="109"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO27607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="232" mass="27046" checksum="609C471F3F554C4B" modified="2016-06-08" version="1">MEQPLKKGGDVPRIPWAFAMTEVCGVILCYIWLLVLLLHKHRSILLRRLCSLMGTVFLLRCITMFVTSLSVPGQHLQCSGKLYGNVWAKLQRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYHQSRRARIWFPMFSFFECNVNGTVPNEYCWPFSKPAIMKRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MT96</accession>
    <name>A0A151MT96_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0728 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MT96"/>
    <dbReference type="KEGG" id="amj:102568402"/>
    <dbReference type="eggNOG" id="ENOG502S4W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10003460at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MT96"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027885">
        <property type="entry name" value="UPF0728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28448">
        <property type="entry name" value="UPF0728 PROTEIN C10ORF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28448:SF1">
        <property type="entry name" value="UPF0728 PROTEIN C10ORF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15092">
        <property type="entry name" value="UPF0728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="92" mass="10306" checksum="13B50BD8EE767F75" modified="2016-06-08" version="1">MPRRALVSLRFGLSRRCGQLAHWTGRLRGLRAVLEADGHQVILEEMPDWNVVELVVNGETVFQCNIKDLDFGGDGKLDPLCEEARVAVLNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUU3</accession>
    <name>A0A151MUU3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrous sheath-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FSIP1</name>
        <name evidence="5" type="ORF">Y1Q_0015934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FSIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUU3"/>
    <dbReference type="eggNOG" id="ENOG502RXFB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026246">
        <property type="entry name" value="Fsip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22012">
        <property type="entry name" value="FIBROUS SHEATH INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22012:SF2">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15554">
        <property type="entry name" value="FSIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02075">
        <property type="entry name" value="FIBSHEATHIP1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="491" mass="55073" checksum="15C8CB9C0D809799" modified="2016-06-08" version="1">MQNSELSEYISSSDSGEDCVETEPPNLNKASQEQSSNVKEEVSEEKDVDPKIEEAIRKMNKLDKILAKKQSQERTIKKQGREMRTKLWEELQCVITLSASGSHEEIENTNTFLALTSSLHERADCQNEMETGGLFNKAEKSHYGSDTRIKKNQDFIKKNIELAKDSGNQVVMLEEEKKRLIELLKDTEDGNELQDTEEDTSGWLVAGEGYTPEPMEFHHLNEIAAKLQIIVSNGDFSIIHSSCSNVPSQIYQESLAYANRNLEAAPGEKVLRDTKEQRDQQVRLKEIDQQLKNLLGNLPEELPCLSEEQLKTLLEECMQSQRTISNVPMSKSQELLSDENFFSCYTTQDATLLSMSTLSNPLGETHSVRMSADQENAGLEDKNEHNCAENESPGFCLTKAIADSHLSKDLVVQTEEPNDLESLQEIADMNSAEGYFMSRALSTKSLKKPSFLDEPFYGISVNNELSTEADIPSIPLQTKGDGLKVKDAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV69</accession>
    <name>A0A151MV69_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV69"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="90" mass="10723" checksum="12C0F9EBA923C341" modified="2016-06-08" version="1">MSKEKLESLLKNMEIMLSEVEQLKIHCTKQTEEVNQIVQELRRENKDMTQKHERICQDLKEAKELVVQLQDTKVAFEAKERQAQKLSRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVM2</accession>
    <name>A0A151MVM2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Myotubularin-related protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Inactive phosphatidylinositol 3-phosphatase 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0005349</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004889">
        <property type="protein sequence ID" value="KYO28552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVM2"/>
    <dbReference type="STRING" id="8496.A0A151MVM2"/>
    <dbReference type="KEGG" id="amj:102564893"/>
    <dbReference type="eggNOG" id="KOG1089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13211">
        <property type="entry name" value="PH-GRAM_MTMR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14536">
        <property type="entry name" value="PTP-MTMR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000240">
        <property type="entry name" value="Myotubularin-related protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF56">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="14">
        <location>
            <begin position="124"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO28552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="550" mass="63469" checksum="2334272191BB9945" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVT5</accession>
    <name>A0A151MVT5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein INCA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">INCA1</name>
        <name evidence="1" type="ORF">Y1Q_0020305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004859">
        <property type="protein sequence ID" value="KYO28605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVT5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026238">
        <property type="entry name" value="INCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15142">
        <property type="entry name" value="INCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02102">
        <property type="entry name" value="PROTEININCA1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="276" mass="31018" checksum="2C7C8FC34B9DCBC5" modified="2016-06-08" version="1">MKCGGDVFLLAGARKGSSGPHALRKMHACFERERTEPIRMALHQGNMEEAFGTSFSPFAKQSRLVSRREPDEAAAGQRHPYDPKEQLWEWLYQPLSPPRRKEDREPIQLLVSGFAARSPNMLTDVLPCPALCLSQELPSPRELCRQRRGQGKCKRVETSSVTSVCSHLAELKRRQSSIDELKKQTWGGYMSHTASEDQDGTAEIPRDSLTHRATLTALWPGNVDLLFGGWSKQPKYPGWSPDVGDPYELAPMDEPPLPAPCCLLETFWGFGWCPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MW43</accession>
    <name>A0A151MW43_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0000831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004838">
        <property type="protein sequence ID" value="KYO28668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MW43"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001468">
        <property type="entry name" value="Zinc finger protein 672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000180">
        <property type="entry name" value="Zinc finger protein 689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000933">
        <property type="entry name" value="zinc finger protein 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000873">
        <property type="entry name" value="Zinc finger protein 841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001630">
        <property type="entry name" value="Zinc finger protein 888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO28668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="445" mass="51511" checksum="B10FCCA3230D11B8" modified="2016-06-08" version="1">MPSKTWGCREEFEKLREMKNPRRKIHQKERYHPNLTGRGRAYAHLRVHREKRQYRCVTCGQTFTQFFSLAQHRRIHLGRKAHRCTKCRKNLICCKDLSQHRCWQKGEQPHHCNMCGKSFRHPSTLARHRRVHTREQSHQYSECTKTVTHSSSLAKHQDVHIGEKPRQCPDSGQSLTCPSHLAQQQLIHTREQPHQCSVCGKSFIYSSHLARHQLIHTGEKPHQCLVCGKCFTYSFNQAQHQRIHTGEKPYQCSECGKSFTRSSHLAEHERIHTGEKPHQCPKCGKCFTLSSSLAHHQRIHTGQKPHQCSVCGKTFGHSSHLAHHQRIHTGEKPHRCSECGKRFTQSSHLAQHQRIHTGEKPYQCPECGRRFGHSSHLAQHQRIHTGEKPHRCPECGKSFGQSSDLARHQRVHTGEKPHQCSECGKSFTQSSSLARHQCIHTQEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWF6</accession>
    <name>A0A151MWF6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWF6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="8067" checksum="1C05A3F9CF9CF937" modified="2016-06-08" version="1">MVPPNRFSVFRTALRRPQFLPYEFTEADFFGTEDWPEQVWLWVRFTPYPVSDHDRSRSPIMEWTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXB7</accession>
    <name>A0A151MXB7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXB7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="10855" checksum="BFC3CE18C63BDF54" modified="2016-06-08" version="1">MGERPDVTKKEWYIQELAENIPSAFGTEDPEKDPEKHLVQRSILLHSASYGHRSMMSCPANPHSLKEQPLINHGSDATHRSTSVSSTPARATTSGMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXV5</accession>
    <name>A0A151MXV5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXV5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8821" checksum="79545A92B4AD6340" modified="2016-06-08" version="1">MMKQEPLQTALVLIYYQAEDGQSRQILNTENALALLKKELACKHLKRRNQQNELKNSRTFLLPSLPLPGSCRELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MY24</accession>
    <name>A0A151MY24_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Antizyme inhibitor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ornithine decarboxylase antizyme inhibitor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AZIN1</name>
        <name evidence="11" type="ORF">Y1Q_0017988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Interacts with OAZ1 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001278688.1">
        <property type="nucleotide sequence ID" value="NM_001291759.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019351236.1">
        <property type="nucleotide sequence ID" value="XM_019495691.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MY24"/>
    <dbReference type="STRING" id="8496.A0A151MY24"/>
    <dbReference type="GeneID" id="102572282"/>
    <dbReference type="KEGG" id="amj:102572282"/>
    <dbReference type="CTD" id="51582"/>
    <dbReference type="eggNOG" id="KOG0622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MY24"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042978">
        <property type="term" value="F:ornithine decarboxylase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902269">
        <property type="term" value="P:positive regulation of polyamine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06831">
        <property type="entry name" value="PLPDE_III_ODC_like_AZI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000008">
        <property type="entry name" value="antizyme inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000010">
        <property type="entry name" value="Antizyme inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031178">
        <property type="entry name" value="Azin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF7">
        <property type="entry name" value="ANTIZYME INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="10">
        <location>
            <begin position="46"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO29355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="449" mass="50286" checksum="101C4097D4AFABB1" modified="2016-06-08" version="1">MKGLPEDANYSIGLLDEGITPADVIDNYIFEQTHTGKKAFFVGDLGKLMKKHIEWQNMMAPIKPFYPVRCNSTPAVLEILAALGTGFVCSSKTEMAMLQDLAIAPENIMYINPCKQASHIKYAAKAGINIMTCDNDIELQKIARNHPNARLLLHIATEEINGVEEMSMKFGTTLKNCRHLMELAKELEVQIVGVKFHVSNSCKEPQVYLHAVSDARCVFDMAEEFGFKMNILDIGGSFTGSELQLKEVNRVISPLLVDYFPEESGVNVIAEPGCYYVSSAFTLAVNIIAKKAVEYDKHLSSGMEQARSDEPIFMYYMNDGVYGSFANKLSEKLNAIPEVHKKYKEDEPLFASSLWGPSCDELDEIVESCLLPELSVGDWLIFDNMGSGTLGERSTFNDYQRPLTYYVMSFSDWYEMQDAGITSDTLMKNFFFVPSCIQLSPEDRFSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZI2</accession>
    <name>A0A151MZI2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neuromedin-U receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NMUR1</name>
        <name evidence="15" type="ORF">Y1Q_0013787</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for the neuromedin-U and neuromedin-S neuropeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004458">
        <property type="protein sequence ID" value="KYO29888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZI2"/>
    <dbReference type="STRING" id="8496.A0A151MZI2"/>
    <dbReference type="GeneID" id="102560918"/>
    <dbReference type="KEGG" id="amj:102560918"/>
    <dbReference type="CTD" id="10316"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15358">
        <property type="entry name" value="7tmA_NMU-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000214">
        <property type="entry name" value="Neuromedin U receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005391">
        <property type="entry name" value="NeuromedU_rcpt_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF109">
        <property type="entry name" value="NEUROMEDIN-U RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01566">
        <property type="entry name" value="NEUROMEDNU1R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="73"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO29888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="425" mass="48574" checksum="1EBB27CE438441D8" modified="2016-06-08" version="1">MYPYTNCTSLAPLRDYLARLEAEVLCNHSHVDPEDMTLTEDELRDKYLGPRRSSFFVPVCTTYLLIFVVGAVGNTLTCLVILRHKFMRTPTNYYLFSLAVSDLLVLLLGMPLELYDMWSNYPFLLGAGGCYFKTLLFEAVCFASILNVTALSVERYIAVVHPLKAKYVVTRNHAKRVIGAIWVLSVLCSIPNTSLHGIRPLYVPGRGVVPDSAICMVVKPLVLYNLIIQITTILFFFLPMGTLSILYLLIGLQLRKEKMLQSLEAKAGRDSDYHHVRAQQKKVRRRQVTKMLFVLVVVFGICWAPFHTDRLVWSFVSNWTGNMHEMFQYVHIISGVFFYLSSATNPILYNLMSTRFREMFKEVMCHQHLQRLGSRKYSPSVTRVTTRSTVCEHVPSGNGLPLANLEEYETDREGERSNEHAAVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0E9</accession>
    <name>A0A151N0E9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004278">
        <property type="protein sequence ID" value="KYO30303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0E9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="77" mass="8778" checksum="B2E571AA3E12F2B3" modified="2016-06-08" version="1">MHSHFSEASNSASKTWTGWAELGRDNTVADFLSWCHLAEDHEEQHTAHLGKERPAREETAVGEESFLCQHPNHQYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1D9</accession>
    <name>A0A151N1D9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1D9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="133" mass="15383" checksum="C8C02EDB6281A2CD" modified="2016-06-08" version="1">MPMTTAYVLGQNLQALTQILGSQQQMLDRQQDCLQHSLASFKMPKMMRDDDPEAYIEAFERHAFMTGLNQEYWASQLGALVVGKAQAAYWALPRDEARDYARVKQVILYQLEISPDHYRRLFRTKKGPGERCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2R3</accession>
    <name>A0A151N2R3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2R3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="142" mass="15923" checksum="5D69AB94A271233F" modified="2016-06-08" version="1">MQMKPKSCVWSQRAGKSSQGVQILTSDPPETRDAPWLTWRRPWAGLVLQGDRQSCSHAKLLPECKYRLQLRLRVAGMGYLDRTRLAGAQGLSPRRRGDTQGTWRPTWGAILLTLLLPARDPQPSSSDVFHPPAYSTCTSRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N487</accession>
    <name>A0A151N487_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Guanylate cyclase</fullName>
            <ecNumber evidence="19">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Y1Q_0004730</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Photoreceptor outer segment membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03004069">
        <property type="protein sequence ID" value="KYO31581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N487"/>
    <dbReference type="eggNOG" id="KOG1023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06371">
        <property type="entry name" value="PBP1_sensory_GC_DEF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14043">
        <property type="entry name" value="PK_GC-2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000404">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000013">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000114">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF228">
        <property type="entry name" value="RETINAL GUANYLYL CYCLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16 19" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="681"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="24">
        <location>
            <begin position="1042"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1228"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="979"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1249"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO31581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1288" mass="141715" checksum="E74563086E9F9754" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5U9</accession>
    <name>A0A151N5U9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras GTPase-activating protein-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GAP SH3 domain-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">G3BP2</name>
        <name evidence="20" type="ORF">Y1Q_0012195</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms homooligomers. Forms heterodimers with G3BP1. Interacts with NFKBIA (via N-terminus). Interacts (via NTF2 domain) with USP10; inhibiting stress granule formation. Interacts (via NTF2 domain) with CAPRIN1; promoting stress granule formation. Associates (via RG-rich region) with 40S ribosome subunits. Interacts with PABPC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004011">
        <property type="protein sequence ID" value="KYO31969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014467051.2">
        <property type="nucleotide sequence ID" value="XM_014611565.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5U9"/>
    <dbReference type="STRING" id="8496.A0A151N5U9"/>
    <dbReference type="GeneID" id="102570278"/>
    <dbReference type="KEGG" id="amj:102570278"/>
    <dbReference type="CTD" id="9908"/>
    <dbReference type="eggNOG" id="KOG0116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N5U9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12464">
        <property type="entry name" value="RRM_G3BP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000002">
        <property type="entry name" value="Ras GTPase-activating protein-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000327">
        <property type="entry name" value="ras GTPase-activating protein-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034376">
        <property type="entry name" value="G3BP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF10">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="NTF2" evidence="19">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="345"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="155"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="422"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO31969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="496" mass="55859" checksum="20196C0E0EF51665" modified="2016-06-08" version="1">MPWQTRYLTLCTKEMVMEKPSPLLVGREFVRQYYTLLNKAPDFLHRFYGRNSSYVHGGLDASGKPQEAVYGQAEIHKKVMSLQFSECHTKIRHVDAHATLSDGVVVQVMGELSNSGQPMRKFMQTFVLAPEGSVPNKFYVHNDIFRYEDEVFGDSEAELDEESEEEVEEEQEERQPSPEPVQENTSSTYYESHPVTNGIEEPLEESSHEPEPDLESETKAEELKPEVEEKNLEELEEKSPSPPPAEPVSLPQEPPKAFSWASVTSKNLPPSGTVSSSGIPPHVKAPVSQPRVETKPEAQSQPPRVREQRPRERPGFPPRGPRPGRGDMEQNESDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELRINTKGVGGKLPNFGFVVFDDSEPVQRILVAKPIMFRGEVRLNVEEKKTRAARERETRGGGDDRRDIRRNDRGPGGPRGIVGGGMMRDRDGRGPPPRGGMAQKLGSGRGTGQMEGRFTGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8C6</accession>
    <name>A0A151N8C6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTPase Era, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ERA-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ERAL1</name>
        <name evidence="19" type="ORF">Y1Q_0020537</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003808">
        <property type="protein sequence ID" value="KYO33074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N8C6"/>
    <dbReference type="eggNOG" id="KOG1423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002220">
        <property type="entry name" value="GTPase Era, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000016">
        <property type="entry name" value="GTPase Era, mitochondrial isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Era-type G" evidence="18">
        <location>
            <begin position="77"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="16">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="16">
        <location>
            <begin position="111"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="16">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="16">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="16">
        <location>
            <begin position="323"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO33074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="452" mass="49570" checksum="DD281D1AB00C5C77" modified="2016-06-08" version="1">MLRGGARWRHPAPRXXXXWLLERRAWGAACPTSCAGGRATPNDTLGLPREHPPPVPACGAERGRLLVHQPDQPDNPKVLRVAIIGAPNAGKSTLSNQLLGRKVFPVSKKVHTTRCNAHGVVTHEDTQLIILDTPGLTSPQKAKRHNLEKSLISDPWDSMKHADLVLVLVDVSDQWTRNQLSPQVLKCLSQFLQIPSILVLNKVDLLKKKHLLLDLVVQLTEGVVSGKKVAVKPLFKPHSHSTKSTPLQGAQAPLPENAAKESSCPQKAGQAQLGYDSDADSAVRSSGLLHTLEGTGEVPMPSPPVPGDSKKKGWPHFREVFMLAALHADGVETLKRHLLLQAKPGPWEFHSRVLTSQSREEICDNIIREKLLEYLPKEVPYSVLQKMESWSEGPAGELVIQQTLLVQKLTHKNMLIGKDGNMISRIAQEAGSDLSDIFLCDVCLKLGVKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9L7</accession>
    <name>A0A151N9L7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc finger protein Helios isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">IKZF2</name>
        <name evidence="18" type="ORF">Y1Q_0008672</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006264503.1">
        <property type="nucleotide sequence ID" value="XM_006264441.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059583124.1">
        <property type="nucleotide sequence ID" value="XM_059727141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9L7"/>
    <dbReference type="STRING" id="8496.A0A151N9L7"/>
    <dbReference type="GeneID" id="102566839"/>
    <dbReference type="KEGG" id="amj:102566839"/>
    <dbReference type="CTD" id="22807"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N9L7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000073">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000525">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000124">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000372">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000168">
        <property type="entry name" value="zinc finger protein Eos isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF33">
        <property type="entry name" value="ZINC FINGER PROTEIN HELIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="362"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO33476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="526" mass="59554" checksum="442ABA900B4DC6AC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAD7</accession>
    <name>A0A151NAD7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="6">1.3.8.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">KANSL1L</name>
        <name evidence="33" type="ORF">Y1Q_0008667</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(5Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:84650"/>
            <dbReference type="ChEBI" id="CHEBI:87701"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:17721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83721"/>
            <dbReference type="ChEBI" id="CHEBI:83727"/>
            <dbReference type="EC" id="1.3.8.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17722"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>decanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:48177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>docosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47228"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65059"/>
            <dbReference type="ChEBI" id="CHEBI:74692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:47229"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:47297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>octanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:48181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>oxidized [electron-transfer flavoprotein] + (9Z)-octadecenoyl-CoA + H(+) = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47300"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:77553"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:47301"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.8" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAD7"/>
    <dbReference type="STRING" id="8496.A0A151NAD7"/>
    <dbReference type="eggNOG" id="ENOG502QRI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00660"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035035">
        <property type="term" value="F:histone acetyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004466">
        <property type="term" value="F:long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042758">
        <property type="term" value="P:long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01160">
        <property type="entry name" value="LCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000017">
        <property type="entry name" value="long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000020">
        <property type="entry name" value="Long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034179">
        <property type="entry name" value="LCAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026180">
        <property type="entry name" value="NSL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443:SF16">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22443">
        <property type="entry name" value="NON-SPECIFIC LETHAL 1, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15275">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01300">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52052">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PEHE" evidence="32">
        <location>
            <begin position="911"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="809"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="978"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS52052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="KYO33465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1090" mass="122442" checksum="FBB1D51A0D3BBFCD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAI8</accession>
    <name>A0A151NAI8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cullin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CUL3</name>
        <name evidence="16" type="ORF">Y1Q_0024482</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12 13">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276544.1">
        <property type="nucleotide sequence ID" value="XM_006276482.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAI8"/>
    <dbReference type="SMR" id="A0A151NAI8"/>
    <dbReference type="STRING" id="8496.A0A151NAI8"/>
    <dbReference type="GeneID" id="102560971"/>
    <dbReference type="KEGG" id="amj:102560971"/>
    <dbReference type="CTD" id="8452"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NAI8"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000091">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000005">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000006">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="15">
        <location>
            <begin position="383"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO33852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="768" mass="88959" checksum="1CE60A4E27A853F0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NB20</accession>
    <name>A0A151NB20_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-L1 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CCNL1</name>
        <name evidence="6" type="ORF">Y1Q_0024605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NB20"/>
    <dbReference type="STRING" id="8496.A0A151NB20"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20592">
        <property type="entry name" value="CYCLIN_CCNL1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000014">
        <property type="entry name" value="cyclin-L1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="5">
        <location>
            <begin position="142"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="146"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="377" mass="43551" checksum="135996740B9FD3B7" modified="2016-06-08" version="1">MATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHYLRQLRAKSLLHKLYMLLTSTLFSLATDYTATSYIYQTLGDVEWYIEMKLSSWQQTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICLTTLKLYTRKKPNYELLDKEVEKRKMALQEAKLKAKGLNPDGTPALSTLGGFSPASKPCSPREMKTEEKTPVSLNAKAVKKEPEERQLASKSPYNGMRKESKRSRSSRSASRSRSRTKSRSRSHTPRRHYNNRRSLSGTYSSRKSAEADNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBQ0</accession>
    <name>A0A151NBQ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBQ0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7665" checksum="6F8FE935AE64539D" modified="2016-06-08" version="1">MVLLQPEEKKTVPGVITFTPWDWSHRLHSFLHSGAGSPCLGKFLAGSPQVWMPSLEEIDTCKEARPCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDG2</accession>
    <name>A0A151NDG2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hepatocyte nuclear factor 3-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FOXA3</name>
        <name evidence="7" type="ORF">Y1Q_0023300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003320">
        <property type="protein sequence ID" value="KYO34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006265841.1">
        <property type="nucleotide sequence ID" value="XM_006265779.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDG2"/>
    <dbReference type="STRING" id="8496.A0A151NDG2"/>
    <dbReference type="GeneID" id="102565825"/>
    <dbReference type="KEGG" id="amj:102565825"/>
    <dbReference type="CTD" id="3171"/>
    <dbReference type="eggNOG" id="KOG3563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NDG2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20040">
        <property type="entry name" value="FH_FOXA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000042">
        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047366">
        <property type="entry name" value="FH_FOXA3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013638">
        <property type="entry name" value="Fork-head_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018533">
        <property type="entry name" value="Forkhead_box_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF201">
        <property type="entry name" value="HEPATOCYTE NUCLEAR FACTOR 3-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08430">
        <property type="entry name" value="Forkhead_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09354">
        <property type="entry name" value="HNF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="145"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="145"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="419" mass="45141" checksum="71307C969F2F7187" modified="2016-06-08" version="1">MLGSVKMETHDLAEWNSYYSEPAEVYPSVSTMTSGLGPMNTINSYMTLNSLSSPGSMNMTYPSGGLSSPSLPGLPGTASAMGLGSVASPVSPALTPLGAQAPSINALSPYQSVSPSAAPLGYPAAGIARPKELSKSYRRTLTHAKPPYSYISLITMAIQQAPSKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPNSGNMFENGCYLRRQKRFKIEDKAKKPSAKGSATQDQAPKRPEGVPEGRSPPTGSEGAESGHSDASHGSEEQRGLVQLDCSGVQGSPPGSATSPVPISPSITSHYFPPSIASLELPGDLKMDPQYNFNHPFSITNLMSSEQSHKVDLKAYEQVMAYNGYGSSPAAESKHGYEPATSLAETGPYYQSLYSRSLLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NE86</accession>
    <name>A0A151NE86_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NE86"/>
    <dbReference type="STRING" id="8496.A0A151NE86"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF26">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="170" mass="18966" checksum="F5413BE21146FBFE" modified="2016-06-08" version="1">MTFIDLTKASDTVRLAGLWKIMAKFDSPEKLIAMVQQFHGGMLARIVIDGESSEPFPVTSAVKQGRVLPSTLYSRMFSAMLTDAFCDCDTGIDISYQTDDNLFNLWRLEMKMKSQEVTVHDLLFADDGSLNDKSESDMQQSMDHFSSTCDNFALTIITKKMSQQGPAEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGX9</accession>
    <name>A0A151NGX9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BTB/POZ domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BTBD2</name>
        <name evidence="4" type="ORF">Y1Q_0011992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003034">
        <property type="protein sequence ID" value="KYO36004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGX9"/>
    <dbReference type="STRING" id="8496.A0A151NGX9"/>
    <dbReference type="eggNOG" id="KOG2075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18523">
        <property type="entry name" value="BACK_BTBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18281">
        <property type="entry name" value="BTB_POZ_BTBD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000037">
        <property type="entry name" value="BTB (POZ) domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000004">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.820:FF:000004">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF6">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO36004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="444" mass="49603" checksum="0DAC819A3393F1E6" modified="2016-06-08" version="1">MLVDITWWSKTLEVFKATKPTVQERFAFLFNNEVLSDVHFLVGKGRGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVIPENKRKVLGKALSLIRFPLMTIEEFAAGPAQSGILTDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSSNTFRVMFKEPVEILPNVNYTACATLKGPDSHYGTKGLRKVIHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEIIFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHZ0</accession>
    <name>A0A151NHZ0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PR domain zinc finger protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PR domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PRDM4</name>
        <name evidence="20" type="ORF">Y1Q_0024164</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May function as a transcription factor involved in cell differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHZ0"/>
    <dbReference type="STRING" id="8496.A0A151NHZ0"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="SET domain"/>
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        <property type="entry name" value="PRDM4_Znf"/>
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        <property type="entry name" value="Zinc_finger"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRDM2_PR"/>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Zn_ribbon_PRDM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037161">
        <property type="entry name" value="PRDM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="19">
        <location>
            <begin position="474"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="818"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="23"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00059546"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00067589"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082166"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO36418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="863" mass="94894" checksum="E99D47E9EF4D3CFC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIP0</accession>
    <name>A0A151NIP0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">Y1Q_0024310</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="28">Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.</text>
    </comment>
    <comment type="function">
        <text evidence="31">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="24">Cell membrane</location>
            <location evidence="24">Sarcolemma</location>
            <location evidence="24">T-tubule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="31">Membrane</location>
            <topology evidence="31">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Postsynaptic density membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031688">
        <property type="entry name" value="CAC1F_C"/>
    </dbReference>
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        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
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        <property type="entry name" value="CACHANNEL"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    <feature type="transmembrane region" description="Helical" evidence="33">
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    <feature type="compositionally biased region" description="Polar residues" evidence="32">
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            <position position="209"/>
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        <ligand>
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        <ligand>
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        <ligand>
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    <sequence length="1954" mass="220958" checksum="0E2228EDEB0F4B20" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJM0</accession>
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            <taxon>Archosauria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK23</accession>
    <name>A0A151NK23_ALLMI</name>
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            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligator</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Bcl-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK23"/>
    <dbReference type="STRING" id="8496.A0A151NK23"/>
    <dbReference type="GeneID" id="102568113"/>
    <dbReference type="eggNOG" id="KOG4728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6080198at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NK23"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000004">
        <property type="entry name" value="apoptosis regulator BAX isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020726">
        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020728">
        <property type="entry name" value="Bcl2_BH3_motif_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF42">
        <property type="entry name" value="APOPTOSIS REGULATOR BAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01258">
        <property type="entry name" value="BH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01259">
        <property type="entry name" value="BH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="18">
        <location>
            <begin position="81"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO37132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="209" mass="22708" checksum="D93BC53C7A6A1BA2" modified="2016-06-08" version="1">MAEAAEGGGSGGEAPVEPPAGGGGTSSDQILHTGDILLKGFIRERVQRCGDSQAVELGREVLGGPEASLCSNDTKRLSECLRRIGDELDSNTDLQRMIEQVGSQPPKEVFFRVATEMFSDGTFNWGRVVALFYFACKLVLKALCTKVPELVRTILGWTMEYLREHVLVWIQAQGGWEGLLSTLGTPTWQTITIFAAGVLTASLTIWKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLS3</accession>
    <name>A0A151NLS3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Laforin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EPM2A</name>
        <name evidence="8" type="ORF">Y1Q_0022027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002600">
        <property type="protein sequence ID" value="KYO37738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLS3"/>
    <dbReference type="STRING" id="8496.A0A151NLS3"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019203">
        <property type="term" value="F:carbohydrate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044042">
        <property type="term" value="P:glucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05806">
        <property type="entry name" value="CBM20_laforin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14526">
        <property type="entry name" value="DSP_laforin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000054">
        <property type="entry name" value="laforin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034831">
        <property type="entry name" value="CBM20_laforin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045204">
        <property type="entry name" value="DSP_laforin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042942">
        <property type="entry name" value="Laforin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46864">
        <property type="entry name" value="LAFORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46864:SF1">
        <property type="entry name" value="LAFORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="131"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="232"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO37738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="305" mass="34740" checksum="2C4A323CDD46E0F1" modified="2016-06-08" version="1">MTEGGVALLVAGSRPELGQWDPQRALPMKPARPTAPRPAQEPTLWLAEAALPDHEAAAPFWYKFLRRQGDDVTWEGNGPHHDRCCVYNESNFVDGVYCLPIAHWIEVSGHTDEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGVTAVMNFQTEWDINQNSWGCNRYPEPMSPEILMKLYKEEGLAYVWMPTPDMSTEGRIQMLPQAVCLLHGLLENGHIVYVHCNAGVGRSTAAICGWLKYVMGWNLRKVQYFVASRRPAVYIDEEALVRAEDDFYQKFGPLRSSCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSG3</accession>
    <name>A0A151NSG3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tumor necrosis factor ligand superfamily member 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Fas antigen ligand</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="39" type="primary">SUCO-1</name>
        <name evidence="39" type="ORF">Y1Q_0006691</name>
    </gene>
    <organism evidence="39 40">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="39 40" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytoplasmic form induces gene transcription inhibition.</text>
    </comment>
    <comment type="function">
        <text evidence="30">Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="32">Homotrimer. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="34">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="31">Endomembrane system</location>
            <topology evidence="31">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="33">Belongs to the SLP1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="39">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSG3"/>
    <dbReference type="STRING" id="8496.A0A151NSG3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060205">
        <property type="term" value="C:cytoplasmic vesicle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008625">
        <property type="term" value="P:extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046850">
        <property type="term" value="P:regulation of bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00184">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000017">
        <property type="entry name" value="Tumor necrosis factor ligand superfamily member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000099">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028326">
        <property type="entry name" value="FASL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01681">
        <property type="entry name" value="FASLIGAND"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0202">Cytokine</keyword>
    <keyword evidence="28" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="25" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="26" id="KW-0458">Lysosome</keyword>
    <keyword evidence="22 36" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="19" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="24" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14 36" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20 36" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="18" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="36">
        <location>
            <begin position="938"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="38">
        <location>
            <begin position="229"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="37">
        <location>
            <begin position="1111"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="107"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="1078"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="35">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="35">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="35">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="35">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="35">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="35">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00030913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00045660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00047144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00061226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00064635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="EMBL" id="KYO39812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1247" mass="139726" checksum="BCF490A4DF9DDCD5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWW2</accession>
    <name>A0A151NWW2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001657">
        <property type="protein sequence ID" value="KYO41223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWW2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9186" checksum="57EF996E6B0BB67B" modified="2016-06-08" version="1">MQTCCFHLERMNVVGALYSKNPPLLTTIMEIQGHECSQSALPRSDERNLCAASRTKHSYHGLDTATHRSGTQGAGEGGNLWSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYM4</accession>
    <name>A0A151NYM4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Voltage-gated purine nucleotide uniporter SLC17A9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 17 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Vesicular nucleotide transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC17A9</name>
        <name evidence="19" type="ORF">Y1Q_0002631</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles. By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles. Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) = ADP(out)</text>
            <dbReference type="Rhea" id="RHEA:75783"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP(in) = ATP(out)</text>
            <dbReference type="Rhea" id="RHEA:75687"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP(in) = GTP(out)</text>
            <dbReference type="Rhea" id="RHEA:75787"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Secretory vesicle</location>
            <location evidence="9">Chromaffin granule membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO41972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYM4"/>
    <dbReference type="STRING" id="8496.A0A151NYM4"/>
    <dbReference type="eggNOG" id="KOG2532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042584">
        <property type="term" value="C:chromaffin granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160042">
        <property type="term" value="F:purine nucleotide uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072530">
        <property type="term" value="P:purine-containing compound transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000059">
        <property type="entry name" value="Solute carrier family 17 member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000150">
        <property type="entry name" value="Solute carrier family 17 member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF279">
        <property type="entry name" value="VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="18">
        <location>
            <begin position="19"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO41972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="429" mass="47098" checksum="334FC3D36D93C1FF" modified="2016-06-08" version="1">MRKDGNADCYWSRPESRTWTVMLLLGTCLLYCARVTMPICAVAMSSHFEWDKKQSGIVLSSFFWGYCLTQIVGGHLSDRIGGEKVLLLSASAWGFITAITPLLTYVSSAHLIFMTASRFLMGLLQGVYFPALASLFSQKVRESERAFTCSTVGTGSQFGTLVIGGAGSLLLDWYGWESVFYFSGFLTLLWVYCMCKYLLNEKELIIPFEYLAKGLSLSKRTKVPWKRLFKKAPIWAVIVAQLSTGSTFFTLLSWLPTFFKETFPESKGWVFNVVPWLVAILTSLFSGFLSDHLISQGYRTITVRKFMQVIGSGVSSLFALCLGQTSSFCKAIVFASASVGLQTFNHSGISVNVQDLAPSCAGLLFGVGNTGGALLGVVCVYLAGHLIETTGSWISVFNLVATVNIIGLCTFLIFGEAQRVDTVSAYIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1M4</accession>
    <name>A0A151P1M4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc transporter ZIP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0003937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001261">
        <property type="protein sequence ID" value="KYO42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1M4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF17">
        <property type="entry name" value="ZINC TRANSPORTER ZIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586584" description="Zinc transporter ZIP10" evidence="2">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28914" checksum="6B5A4613FCF4B9C3" modified="2016-06-08" version="1">MVLQPWLWLWLWLAPGVAVGHPPEDAEQEQGYYLQQLFGLYGHNGTLAPEGLRRLLRSLGLGRVQVVQIDHEDLGHGHVAHLDALDLQDGRHVHARAHRHSHGHSHDYPGSQGPGNATTSGDMPPALPSPSPTPEAPLAMPTSLTETRSPSPRGDPGPGKDPLGLSLLERVLALDHSVYNHLHEDCLNVSQLLVNFGLAGTAQITPEQFALLCPALLYQIDARVCLHHHPAPAPPVPQPALGPGGGRRCWGQWHQPEHPGPCARSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2G5</accession>
    <name>A0A151P2G5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2G5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO43130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="82" mass="9198" checksum="78EA07E7879ED007" modified="2016-06-08" version="1">MKVPPTVQDNGLAMKEQKELSLLLTKRLLPGQLLLRGRLAEELLLSELLLRAEPSATEYPGLPGIQERLENRKNPGLWSSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2L5</accession>
    <name>A0A151P2L5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0017603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2L5"/>
    <dbReference type="KEGG" id="amj:102570669"/>
    <dbReference type="eggNOG" id="ENOG502S9DQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10043580at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P2L5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040219">
        <property type="entry name" value="KIAA1143-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195:SF2">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO43322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="157" mass="17754" checksum="D9A66D275D6365FD" modified="2016-06-08" version="1">MSKRDQVSYVPPAEPAFLSRFKKEVGYREGPTVDTKREQLPVPEEDDESGSDKEDERPQVVVLKKGDLTEEEALKIKEQIKDASKLDEEPEPSDGKIVFRKPSKRSSEEKFLGLTASSSKKIKESRKNRSEPKISPNAAKQIKNSSLLSFDDEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4D7</accession>
    <name>A0A151P4D7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001049">
        <property type="protein sequence ID" value="KYO43916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4D7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8162" checksum="E20C9792D02B9E90" modified="2016-06-08" version="1">MLFKRQKKRLSSNPLFVRFKEGRASRKRAGLTSADEPSLFSVGLAKHSAWMKSMNTMELTRRTSARDLQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5F9</accession>
    <name>A0A151P5F9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Bactericidal permeability-increasing protein</fullName>
            <shortName evidence="13">BPI</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BPI</name>
        <name evidence="17" type="ORF">Y1Q_0005943</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13">Monomer. Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000865">
        <property type="protein sequence ID" value="KYO44169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5F9"/>
    <dbReference type="STRING" id="8496.A0A151P5F9"/>
    <dbReference type="eggNOG" id="KOG4160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031663">
        <property type="term" value="P:lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00025">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00026">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000001">
        <property type="entry name" value="Phospholipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000001">
        <property type="entry name" value="phospholipid transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030675">
        <property type="entry name" value="BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF84">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002417">
        <property type="entry name" value="Lipid_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="5 13" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="9 12 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0391">Immunity</keyword>
    <keyword evidence="6 13" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586706" description="Bactericidal permeability-increasing protein" evidence="14">
        <location>
            <begin position="27"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="15">
        <location>
            <begin position="34"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="16">
        <location>
            <begin position="256"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR002417-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO44169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="464" mass="50855" checksum="0B395B1506B3C038" modified="2016-06-08" version="1">MAVRMVVRSLALAALMLAACMVLARATNPGFVARITEKGLDYARQEGIAALEKKLAKLKLPDFSGSFKVKPFGNVHYEFYSLDLRSFQLPSSQIVPVPNVGLRVSVSKAFAHLTGKWKVKKRFIKDHGSFDLKVEGISISIGLKLGSDASGRPTVTTSECSTQISNVRIHISGRFGWLYKLFHKKIESSFRKTMESKVCEEVTSSVSTQLQPYLQTLPVTTKIDNVAGIDYSLGEFFSLAHRLPAPFPPPALAFPTEHDRMVYLGASSYFFNTAGFVYQTAGVLVFNITDDMVPKGVEFHLNTSTFSAFIPKLEKLYPDRLMKLQVMTSSAPSLTITPGGLSLMPVVDIQAYAILSNSSLAPLFLLSLTSNISATVAVNSSRIGGTLALGRLKLSLKHSDVGPFSVQLLQSLMNIYGSKILLPRLNERLKAGFPLPLPDRIKLSSILLQPHQNFLLLAADVHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5W4</accession>
    <name>A0A151P5W4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuronal pentraxin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0010995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000769">
        <property type="protein sequence ID" value="KYO44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5W4"/>
    <dbReference type="STRING" id="8496.A0A151P5W4"/>
    <dbReference type="KEGG" id="amj:102575491"/>
    <dbReference type="eggNOG" id="ENOG502RD3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8871962at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P5W4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00152">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000012">
        <property type="entry name" value="neuronal pentraxin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF3">
        <property type="entry name" value="NEURONAL PENTRAXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586711" evidence="9">
        <location>
            <begin position="20"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="10">
        <location>
            <begin position="324"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="249"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="527" mass="59185" checksum="8179A09E4EA357CA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6J1</accession>
    <name>A0A151P6J1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein 436-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0008130</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000746">
        <property type="protein sequence ID" value="KYO44519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6J1"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002005">
        <property type="entry name" value="Zinc finger protein 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000987">
        <property type="entry name" value="Zinc finger protein 275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000213">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB-related" evidence="15">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB-related" evidence="15">
        <location>
            <begin position="156"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="159"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO44519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="71912" checksum="C1DEF457379A73A6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6M0</accession>
    <name>A0A151P6M0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-39kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NDUFA9</name>
        <name evidence="17" type="ORF">Y1Q_0016826</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4. Interacts with CLOCK. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the complex I NDUFA9 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273618.1">
        <property type="nucleotide sequence ID" value="XM_006273556.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6M0"/>
    <dbReference type="STRING" id="8496.A0A151P6M0"/>
    <dbReference type="GeneID" id="102569813"/>
    <dbReference type="KEGG" id="amj:102569813"/>
    <dbReference type="CTD" id="4704"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P6M0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000246">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="16">
        <location>
            <begin position="62"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO44708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="382" mass="43687" checksum="6FBABD89CE45BFDB" modified="2016-06-08" version="1">MAALARCAQGPRVLLALPRAGSRVSALSSSASPVLQQHRHVHYAVLPHGRSGRSSVSGIVATVFGATGFLGRYVVNRLGRIGSNIILPYRCDQYYLMYLRPMGDLGQIVFLEWDCRDKDTIQRAVENSNVVINLVGKEWETKSFSFEDTFVNIPRDIARISREAGVEKFIHISHLNADMKSPSKYLKNKAVGELAVREEFPDAIIMKPSEMFGREDRFLNHYANMRRLGGVPLIAFGKKTEKQPVYVIDVAKAIINAIKDPDSKGKTYTLTGPHRYLLYDLVEYVYALSYRIYRPYPLPRSIYHLIVRLFEMNPFEPWITRDKVDRFHTTDKKLPDLFGFEDLGIQPTPLEEKAIEVLRRHRRFRWLDAHVDEAKPAKTVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P838</accession>
    <name>A0A151P838_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein EFR3 homolog A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein EFR3-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EFR3A</name>
        <name evidence="9" type="ORF">Y1Q_0014657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P838"/>
    <dbReference type="STRING" id="8496.A0A151P838"/>
    <dbReference type="eggNOG" id="KOG1877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000347">
        <property type="entry name" value="EFR3 homolog A (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF1">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO45193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="892" mass="100024" checksum="F4BFC5622BA8E720" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8L1</accession>
    <name>A0A151P8L1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000567">
        <property type="protein sequence ID" value="KYO45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8L1"/>
    <dbReference type="STRING" id="8496.A0A151P8L1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9184" checksum="E392D465313E8D60" modified="2016-06-08" version="1">MSPWASPVVLVWKQVGSIRFCVDYWKLNAIAIPDVYPMPKMDTLLDHLGPAKVISTLDLSKGFCKIALDPDAIAKSAFTPPIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9H8</accession>
    <name>A0A151P9H8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9H8"/>
    <dbReference type="STRING" id="8496.A0A151P9H8"/>
    <dbReference type="KEGG" id="amj:102566467"/>
    <dbReference type="eggNOG" id="ENOG502TDDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9031638at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P9H8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO45405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="223" mass="25618" checksum="0DEEB89BDE86E7F1" modified="2016-06-08" version="1">MPDQKWYRRNCIKEPFCVLSTSGGLKTRRRNVLFRNKFLDTYSGYPEDMTTRSDYSLNFSNNRNRRRIQFLQAFKTPEAVAWADIFLSEDQEFPHTSSNSVLTATETQDDIYMEPIHGSKIPMEKNSKEKIAFPTRLTRPFELSRKSGVIMEAMSHTPDYSLFMDIDPSKSGGFLDSLGTAALQPLLLDCDGSMQEESIIQSKQVLPILDWVGEKLRSKLHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PC58</accession>
    <name>A0A151PC58_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Keratin, type I cytoskeletal 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytokeratin-14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Keratin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KRT14</name>
        <name evidence="15" type="ORF">Y1Q_0018442</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PC58"/>
    <dbReference type="STRING" id="8496.A0A151PC58"/>
    <dbReference type="eggNOG" id="ENOG502R8V7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF368">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0416">Keratin</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="14">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="IF rod" evidence="14">
        <location>
            <begin position="358"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="100"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="412"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO46697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="729" mass="83602" checksum="68E1657EE8E5FE89" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PD24</accession>
    <name>A0A151PD24_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PD24"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="86" mass="9575" checksum="8A668C0698F8BD2D" modified="2016-06-08" version="1">MAGDWLLGELNSDCTGLWLKEVTCSKKKELLSWTAGLSVLHPQVPAYKPYQTSLTSPTPACNEFSTLPFAGKIEKETQMHCCRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDM2</accession>
    <name>A0A151PDM2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vesicle-trafficking protein SEC22c isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SEC22C-1</name>
        <name evidence="13" type="ORF">Y1Q_0014576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in vesicle transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO47039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDM2"/>
    <dbReference type="STRING" id="8496.A0A151PDM2"/>
    <dbReference type="eggNOG" id="KOG0862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059071">
        <property type="entry name" value="SEC22a-c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043546">
        <property type="entry name" value="Sec22a/c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46258">
        <property type="entry name" value="LONGIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46258:SF2">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25970">
        <property type="entry name" value="SEC22a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="12">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO47039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="275" mass="30957" checksum="AC7A20EB501B327E" modified="2016-06-08" version="1">MVVLMSTPAEDVHDLLCLCGAGTARGRDLSIHFLSSGEIASMVICSSSYSTIMAFCFLEELQWEFAAAYDTTSIGLASRPYAFLEFDNIIQNVKCHFNYTGCSQMKISLEKIQEELKFRPPVLLKLEDMELMNGLTNGGHTELYMGSVPTYRMQPVTAIGILSLVLNIMCGALNLIRGVHLAEYSFQEDHEGIGNVIAFFLPFLACIFQCYLYLFYSSARKMKVFVLFFSICLCNMYLYGLRNVWQILFHIGVASLSSYQILTRQLVEKQPDPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDT3</accession>
    <name>A0A151PDT3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000483">
        <property type="protein sequence ID" value="KYO47109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDT3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9584" checksum="A65E7A975245D2B7" modified="2016-06-08" version="1">MPNMMMSSVNHRLPGGERPAVEEVDFKDLLCHYRIIPTAYFGEQAKQLNFLEKHISGLCGKNYMGLNLRPKASRATPGRYDGISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFC5</accession>
    <name>A0A151PFC5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromodomain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0019611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFC5"/>
    <dbReference type="STRING" id="8496.A0A151PFC5"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05512">
        <property type="entry name" value="Bromo_brd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000007">
        <property type="entry name" value="Bromodomain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF12">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="6">
        <location>
            <begin position="136"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="7">
        <location>
            <begin position="614"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="83422" checksum="724E203D1031B88C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGB7</accession>
    <name>A0A151PGB7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PSMB2</name>
        <name evidence="7" type="ORF">Y1Q_0001878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014460535.1">
        <property type="nucleotide sequence ID" value="XM_014605049.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGB7"/>
    <dbReference type="STRING" id="8496.A0A151PGB7"/>
    <dbReference type="GeneID" id="102561558"/>
    <dbReference type="KEGG" id="amj:102561558"/>
    <dbReference type="CTD" id="5690"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO48059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="201" mass="22834" checksum="275A3B2CB6A36D87" modified="2016-06-08" version="1">MEYLIGIQGHDYVLVASDTVAASSIVQMKHDHEKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADYLRSRTPYHVNLLLAGYDDHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYKPSISREEAVELLKKCLEELQKRFILNLPSFSVRLIDKDGIHEMDNISLPKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGC7</accession>
    <name>A0A151PGC7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGC7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="11048" checksum="BA4BD0025008B6B0" modified="2016-06-08" version="1">MSSVTWQSHAHLIWKENKPRSICSRLAKKRTFLNGNKSRAFCDCVNSAASRFHNQLYPSSVGRIMTPLIAAVYHLLILKQFSNWTCCGLQVNMTGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGH1</accession>
    <name>A0A151PGH1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGH1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="282" mass="30778" checksum="0B224BAA4D752E2F" modified="2016-06-08" version="1">MWVSVKKPCAAWSPVLGPASWTQERSPPDPATAGLCAQAVKGSAVKHWFQLLPGPVEDTKTCRTWLQQHAAFGLKTALATYLAAVCGLHETQLPSILAAATSWHNTGHMFSDPLSGLECTQLPFSFSGSPAAEQHNRSHLGSEDLCCQSDDERILQSWTRPFRGRAVASIRQDPGSGELAWQQQPMPESEWLRGQEVTTKQAYGGWSRSPSSRVRNRACNPDSKSPALTTNSYSCKITPQHGSQTSTVLQLQAHPDKSAESDPPVKINYPRYSCPCHNTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHE7</accession>
    <name>A0A151PHE7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cyclic nucleotide-gated cation channel beta-1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CNGB1</name>
        <name evidence="19" type="ORF">Y1Q_0024690</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000227">
        <property type="protein sequence ID" value="KYO48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHE7"/>
    <dbReference type="STRING" id="8496.A0A151PHE7"/>
    <dbReference type="eggNOG" id="KOG0499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000072">
        <property type="entry name" value="Cyclic nucleotide gated channel beta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000020">
        <property type="entry name" value="Cyclic nucleotide-gated channel beta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF8">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0140">cGMP</keyword>
    <keyword evidence="8" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="338"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="513"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="589" mass="67431" checksum="4D7A317A0254506D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ05</accession>
    <name>A0A151PJ05_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P2Y purinoceptor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">P2RY2</name>
        <name evidence="14" type="ORF">Y1Q_0020594</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000111">
        <property type="protein sequence ID" value="KYO49101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267904.1">
        <property type="nucleotide sequence ID" value="XM_006267842.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019345210.1">
        <property type="nucleotide sequence ID" value="XM_019489665.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ05"/>
    <dbReference type="STRING" id="8496.A0A151PJ05"/>
    <dbReference type="GeneID" id="102572862"/>
    <dbReference type="KEGG" id="amj:102572862"/>
    <dbReference type="CTD" id="5029"/>
    <dbReference type="eggNOG" id="ENOG502QSTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10018446at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031686">
        <property type="term" value="F:A1 adenosine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045028">
        <property type="term" value="F:G protein-coupled purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045030">
        <property type="term" value="F:G protein-coupled UTP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070257">
        <property type="term" value="P:positive regulation of mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15373">
        <property type="entry name" value="7tmA_P2Y2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000017">
        <property type="entry name" value="lysophosphatidic acid receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000356">
        <property type="entry name" value="P2Y2_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231:SF17">
        <property type="entry name" value="P2Y PURINOCEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231">
        <property type="entry name" value="PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00594">
        <property type="entry name" value="P2Y2PRNOCPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="55"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO49101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="358" mass="40633" checksum="310633C446D3F60F" modified="2016-06-08" version="1">MENFTVLHAWTKSTNTSAAGCATDENPYKCKFDEEFKYILLPVSYGIVCVVGLCLNLLALYIFLFRIKTWNASTTYMFNLAVSDTLYVVSLPLLVYYYAKGDNWPFSVGLCKIVRFLFYTNLYCSILFLLCISAHRFMGICFPLKSLKWGHVRYARRVSGIVWLVIIICQSPVLFFVTTSMKCNAITCHDTSSKELFGQFVIYSSVMLVLLFCIPFLIIIVSYCLMARKLLQPTQGTSRMSKSKKKSVKMIIIVLVVFIVCFLPFHITRTLYYSFRSWDLGCSTLNAINLAYKVTRPLASTNSCLDPILYFLAGQRFMKFTGKKTPAKIQRAVALENAASSNMGISDNTNMIVKDVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ63</accession>
    <name>A0A151PJ63_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 17">Peroxisome proliferator-activated receptor gamma</fullName>
            <shortName evidence="17">PPAR-gamma</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Nuclear receptor subfamily 1 group C member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PPARG</name>
        <name evidence="20" type="ORF">Y1Q_0013936</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterodimer with other nuclear receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 17">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000123">
        <property type="protein sequence ID" value="KYO49022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ63"/>
    <dbReference type="STRING" id="8496.A0A151PJ63"/>
    <dbReference type="eggNOG" id="KOG3575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010887">
        <property type="term" value="P:negative regulation of cholesterol storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045923">
        <property type="term" value="P:positive regulation of fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06965">
        <property type="entry name" value="NR_DBD_Ppar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06932">
        <property type="entry name" value="NR_LBD_PPAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000017">
        <property type="entry name" value="Peroxisome proliferator-activated receptor gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000010">
        <property type="entry name" value="Peroxisome proliferator-activated receptor gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003074">
        <property type="entry name" value="1Cnucl_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003077">
        <property type="entry name" value="PPAR-gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022590">
        <property type="entry name" value="PPARgamma_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF488">
        <property type="entry name" value="PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12577">
        <property type="entry name" value="PPARgamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01288">
        <property type="entry name" value="PROXISOMEPAR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01291">
        <property type="entry name" value="PROXISOMPAGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0010">Activator</keyword>
    <keyword evidence="9 17" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="18">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="19">
        <location>
            <begin position="186"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO49022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="453" mass="52082" checksum="830E6FA6A7659BA9" modified="2016-06-08" version="1">MDDHSHSFDIKPFTTVDFSSISSPHYEDIPLARTDQTVLDYKYDIKLQECQSAIKMEPPSPPYFSEKVQLYNKPHEESSNSLMIIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDQIKCKHVSPLQEQNKEVAIRIFQRCQFRSVEAVQEITEFAKNIPGFVNLDLNDQVTLLKYGVHEIIYTLLASLMNKDGVLISDGQGFMTREFLKSLRKPFCDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQIIKKTETDMSLHPLLQEIYKDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PK14</accession>
    <name>A0A151PK14_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">catechol O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LRTOMT</name>
        <name evidence="12" type="ORF">Y1Q_0011116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000012">
        <property type="protein sequence ID" value="KYO49174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PK14"/>
    <dbReference type="STRING" id="8496.A0A151PK14"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042424">
        <property type="term" value="P:catecholamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000054">
        <property type="entry name" value="Catechol O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF1">
        <property type="entry name" value="TRANSMEMBRANE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-1009">Hearing</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO49174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="265" mass="30377" checksum="F7DB62A4F1CA4E08" modified="2016-06-08" version="1">MSQVTEMVSPAIALAFIPFIVTLLIRYRHYFLLFYRAVLLRWLRDHATGISREERAFQYVLTHAIPGDPQHILETFDHWANHREYLSNIGPQKGKILDRLIYENTPLTVLELGTYCGYATILMAQGLPMGARLYTVEMDPRNAAVAEKVIRLAGFDEDTVELIVGPSEEVIPQLKEKHGLLKADFIFMDHWKRCYLRDLQLLEDHNLLAEGATVLADNVIFPGAPHFLQYVKTCGKYQSKTHRTSLQYFRAIPDGMAELTYTGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYP0</accession>
    <name>A0A151LYP0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Centrosomal protein of 290kDa coiled-coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0020016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QPTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097711">
        <property type="term" value="P:ciliary basal body-plasma membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905349">
        <property type="term" value="P:ciliary transition zone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032321">
        <property type="entry name" value="Cep209_CC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026201">
        <property type="entry name" value="Cep290"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879:SF20">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16574">
        <property type="entry name" value="CEP209_CC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein of 290kDa coiled-coil region" evidence="10">
        <location>
            <begin position="1304"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="385"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="480"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="617"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="713"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="806"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="977"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
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            <begin position="1305"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
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            <end position="1509"/>
        </location>
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    <feature type="coiled-coil region" evidence="8">
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            <begin position="1557"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO17389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1687" mass="197937" checksum="C56CB33DBD90A702" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYX4</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Alligator</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <end position="25"/>
        </location>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="159" mass="18732" checksum="C481BA613962049E" modified="2016-06-08" version="1">MKALLPAITCAVTLLFFLLLPSSSCQKDFLNQCQRWNYREGADKVNIQGIKSLTRTLEKWGNSIFWQMKYSLLNNPNALLPEFSSLRPVSTAVDDLLREVRSITKRLAELNERLRIISKTISPIRYNALRSQRLSSVQLQRLPFHQRRRMYIRRRPQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZZ7</accession>
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        <submittedName>
            <fullName evidence="1">Transcription factor Sp9 isoform A</fullName>
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        <name evidence="1" type="ORF">Y1Q_0011497</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">American alligator</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
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                <person name="Iguchi T."/>
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                <person name="Kohno S."/>
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                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
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                <person name="Peterson D.G."/>
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                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
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                <person name="Sawyer R.H."/>
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                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
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                <person name="Guillette L.J.Jr."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="8496.A0A151LZZ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO17828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="137" mass="14310" checksum="3B8A22170E4480A5" modified="2016-06-08" version="1">MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPDLSGFTVATSRGSSGLASGTGAANSAFCLASTSPTSAAESLYPRVGMAHPYESWYKSGFHSTLAAGEVANGAASSWWDVHTNPGSWLETIQFPFIFKTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M112</accession>
    <name>A0A151M112_ALLMI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M112"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="7832" checksum="363B49ACF17DC266" modified="2016-06-08" version="1">MRYYSIGAYSKVVPQTRSDQLGGTGKVQHVTVALFYCALLKLCSEVSSSFGAPVRMQVYRTCLSGCNTCWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1S1</accession>
    <name>A0A151M1S1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin-like protein KIF24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KIF24</name>
        <name evidence="18" type="ORF">Y1Q_0020966</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle. Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with CCP110, CEP97, TALPID3. Interacts with MPHOSPH9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006811">
        <property type="protein sequence ID" value="KYO18451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M1S1"/>
    <dbReference type="GeneID" id="102558275"/>
    <dbReference type="KEGG" id="amj:102558275"/>
    <dbReference type="CTD" id="347240"/>
    <dbReference type="eggNOG" id="KOG0246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09541">
        <property type="entry name" value="SAM_KIF24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000052">
        <property type="entry name" value="Kinesin family member 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF20">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="221"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="552"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="885"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1244"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1324"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1260"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1325"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="311"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO18451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1434" mass="159594" checksum="53ED24258A8FDD69" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1U8</accession>
    <name>A0A151M1U8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1U8"/>
    <dbReference type="STRING" id="8496.A0A151M1U8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000801">
        <property type="term" value="C:central element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010705">
        <property type="term" value="P:meiotic DNA double-strand break processing involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031380">
        <property type="entry name" value="SIX6OS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35449">
        <property type="entry name" value="PROTEIN SIX6OS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35449:SF1">
        <property type="entry name" value="PROTEIN SIX6OS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15676">
        <property type="entry name" value="S6OS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7644" checksum="E2DED9C4FAA391A7" modified="2016-06-08" version="1">MACAEKSPGFNLFDPSVFGAENSSDQMDESYSAGNVNPVSPHKDIGSLFGKSERYSTFYCSVSKDDEYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2E8</accession>
    <name>A0A151M2E8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2E8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7531" checksum="DCF5F4DC357C7F99" modified="2016-06-08" version="1">MVRSRPSGALRPACPHSLSLNYGLELGWSPFSTVKTVLHVWPAHRSERNRTWQLTFPGGEGKEEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3J5</accession>
    <name>A0A151M3J5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PEX7</name>
        <name evidence="12" type="ORF">Y1Q_0019001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267460.1">
        <property type="nucleotide sequence ID" value="XM_006267398.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3J5"/>
    <dbReference type="STRING" id="8496.A0A151M3J5"/>
    <dbReference type="GeneID" id="102561550"/>
    <dbReference type="KEGG" id="amj:102561550"/>
    <dbReference type="CTD" id="5191"/>
    <dbReference type="eggNOG" id="KOG0277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO19068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="325" mass="35932" checksum="DE824807E4354196" modified="2016-06-08" version="1">MQPGGGSATRSQAFRLPGRHGYAVEFSPYLAGRVACATSQHYGIAGCGTLAVLEQNETGIGLLRSFDWSDGLFDVTWSENNEHVLVTSSGDGSLQIWDTANPTGPLQVYKEHTQEAYSVDWSQTRGEQLVVSGSWDQTAKLWDPAVGKSLCTFKGHEGVIYSTIWSPHIPGCFASASGDQTLRVWDVKTPGVKVVIPAHQAEILSCDWCKYDENLLVTGAVDCSLKGWDLRNVRHPVFNLFGHTYAVRRVKFSPFHSTLLASCSYDFTVRFWDFSKPNPLLEIVEHHTEFTCGLDLSLHSRGQVADCAWDETVKIYTPLCLTVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3P2</accession>
    <name>A0A151M3P2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DCTN4</name>
        <name evidence="15" type="ORF">Y1Q_0015794</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006704">
        <property type="protein sequence ID" value="KYO19153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260631.1">
        <property type="nucleotide sequence ID" value="XM_006260569.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3P2"/>
    <dbReference type="STRING" id="8496.A0A151M3P2"/>
    <dbReference type="GeneID" id="102562537"/>
    <dbReference type="CTD" id="51164"/>
    <dbReference type="eggNOG" id="KOG3896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO19153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="460" mass="52460" checksum="6E727E07C13E62E0" modified="2016-06-08" version="1">MASLLQSERVLYLVRGDKELRAPLSQLYFCRYCSELRSLECVSHEVDSHYCPSCLENMPSAEAKLKKNRCANCFDCPCCMHTLSTRATSIPAPLPDDPAKTTMKKAYYLACGFCRWTSRDVGMADKSVASGGWQEPENPHTQRINKLVEYYQQLAQKEKIERDRKKLVRRRNYMPLAFSDKYGLGTRLQRQRSGAPISALAGLSLKEGEDQKEIKIEPADAVEEVEPLPEDYYTRPINLTEVTTLHQRLLQPDFQPICASQLYPRHKHLLIKRSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENIIHVTLMECEERDPDDINSTAKVAVPPKELILAGKDAAAEYDELAEPQDFQDDPDVIAFRKANKVGVFIKVTPQKEEGEVTVSFKMKHEFKNLAAPIRPSEEGDQSSEVIWLTHHVELSLGPMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M954</accession>
    <name>A0A151M954_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rho guanine nucleotide exchange factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ARHGEF2</name>
        <name evidence="13" type="ORF">Y1Q_0001365</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M954"/>
    <dbReference type="STRING" id="8496.A0A151M954"/>
    <dbReference type="eggNOG" id="KOG3520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071875">
        <property type="term" value="P:adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13392">
        <property type="entry name" value="PH_AKAP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000004">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000021">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF18">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="12">
        <location>
            <begin position="183"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="420"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="847"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="910"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO21058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="994" mass="113760" checksum="5A877AD75BE0C35F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBC1</accession>
    <name>A0A151MBC1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBC1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584938" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8152" checksum="55313B6177B39C18" modified="2016-06-08" version="1">MHMASRQPGAQLLQFCCLLVVVERLVCPSDPQSYVTWSLILLAGSGMAIGPEERFQENHGPHWQIRWKKMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBS1</accession>
    <name>A0A151MBS1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBS1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="9263" checksum="4D6EAA113DA18DFA" modified="2016-06-08" version="1">MGDPSGYELPGFLSVHTALQDPMLEERHLFFGIWFNCSGEELFCYPQLISSQHRRNHESIVAGINQELGPHCTRYYIHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MD51</accession>
    <name>A0A151MD51_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CST complex subunit CTC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CTC1</name>
        <name evidence="10" type="ORF">Y1Q_0003026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MD51"/>
    <dbReference type="GeneID" id="102560579"/>
    <dbReference type="KEGG" id="amj:102560579"/>
    <dbReference type="CTD" id="80169"/>
    <dbReference type="eggNOG" id="ENOG502RBD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2314520at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029156">
        <property type="entry name" value="CTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042617">
        <property type="entry name" value="CTC1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14865">
        <property type="entry name" value="CST COMPLEX SUBUNIT CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14865:SF2">
        <property type="entry name" value="CST COMPLEX SUBUNIT CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15489">
        <property type="entry name" value="CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="711"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO22454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1298" mass="143445" checksum="6636ED8C19FB8047" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEC9</accession>
    <name>A0A151MEC9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lebercilin-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Leber congenital amaurosis 5-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0003319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEC9"/>
    <dbReference type="STRING" id="8496.A0A151MEC9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026188">
        <property type="entry name" value="Lebercilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028933">
        <property type="entry name" value="Lebercilin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650">
        <property type="entry name" value="C21ORF13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650:SF9">
        <property type="entry name" value="LEBERCILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15619">
        <property type="entry name" value="Lebercilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lebercilin" evidence="7">
        <location>
            <begin position="58"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO22849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="114" mass="13394" checksum="5C977991D88DB7F9" modified="2016-06-08" version="1">MPRTKEKKLQKKKKNKYGRQGYQIKGSKKLPLKKMRHQNTSFLSNQNTTVSQKKDVLAQRIFSARLHKTKELKNELSDLQHKLEASNVENQLLKQLQYRHLKAIGLRKAVEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFM3</accession>
    <name>A0A151MFM3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFM3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO23311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="94" mass="10148" checksum="9A77CBB2A2C8CBC8" modified="2016-06-08" version="1">MEGDPHFSLLRQLGVDTSKSQGPGQGTREAVPEVLPGAGVVMLQVLHRPSFHPTMDSRHLLLGRKFQPELSVSVSVSPGLAVQQKRLTLPQGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFX0</accession>
    <name>A0A151MFX0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0005788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MFX0"/>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028750">
        <property type="entry name" value="CEP350/CC187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958:SF3">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13958">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN 350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="2078"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1474"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1770"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1813"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2139"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="956"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1813"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1834"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2158"/>
            <end position="2167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO23416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2656" mass="293104" checksum="A6C61693D113F37D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGF8</accession>
    <name>A0A151MGF8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGF8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8141" checksum="1F4943616F21C8B2" modified="2016-06-08" version="1">MFRHSWKATENGYGLKMSAALHRVPPPPSPAHTTLDVLSIVNCLSPKWFSSPPSIGHTGQSSLSVGFNSPLGLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHE8</accession>
    <name>A0A151MHE8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO23956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHE8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="138" mass="15291" checksum="BA1AA6D105D98ED5" modified="2016-06-08" version="1">MVVGPLERQLISGGGTRDSGFLVGCDLPDNSLTSALHKCYLLFRTLAFCKSIVCIPRRKTDPSLNRLVFSGPPCPAFFSARNSGRDLCKKKACLLVGYEVEVWMIPEVKQGYFMQIILLSYTQHAAPELTRSTYLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHL7</accession>
    <name>A0A151MHL7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0004611</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ENOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO24022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHL7"/>
    <dbReference type="STRING" id="8496.A0A151MHL7"/>
    <dbReference type="KEGG" id="amj:106736992"/>
    <dbReference type="eggNOG" id="ENOG502QQ8G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10039782at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12228">
        <property type="entry name" value="RRM_ENOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000083">
        <property type="entry name" value="Putative ecto-NOX disulfide-thiol exchanger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056611">
        <property type="entry name" value="ENOX1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034140">
        <property type="entry name" value="ENOX_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF6">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23267">
        <property type="entry name" value="ENOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="406"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO24022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="623" mass="70947" checksum="FAD4B618FED726E1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MID9</accession>
    <name>A0A151MID9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0004329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MID9"/>
    <dbReference type="STRING" id="8496.A0A151MID9"/>
    <dbReference type="KEGG" id="amj:102563280"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MID9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="57"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO24302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="373" mass="40001" checksum="9275A2CCA4BD3C2F" modified="2016-06-08" version="1">MMASTAARGGLGFRGISWLQRGRRSTSVTDHLGLLSPSNGLPLPSCRRSYRAVLCTELAKPLIIRTIPSPPLQPQEVRVGIHCCGVNFADILACQGLYQEKHALPFAPGMEFSGVVMETGTDVSTVQKGDRVLGVTSSKAMAEECIIDQKMLWQIPDGVSYEHAAALPVSYGTASLALERRAHTQPGETVLVTAAAGATGLATIDIATNVFKAKVIAAAGSDHKCNLALQKGATHSVNYSQNSLKDEVKKLTDNRGVNVAIDAVGGDIFKQALHSLAWEGRIVVVGFAGGTIPSFSANLLLLKNVSAMGVYWGRYREEEFPLFSSSISSALQYCHEGKIEPHIGEVFKLEEVNEAFSHVIQRKSTGKVIISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIM4</accession>
    <name>A0A151MIM4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinetochore protein NUF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cell division cycle-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Kinetochore protein Nuf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NUF2</name>
        <name evidence="18" type="ORF">Y1Q_0004369</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006099">
        <property type="protein sequence ID" value="KYO24357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIM4"/>
    <dbReference type="STRING" id="8496.A0A151MIM4"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000001">
        <property type="entry name" value="NDC80 kinetochore complex component NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="17">
        <location>
            <begin position="93"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO24357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="553" mass="64289" checksum="BBA2FFCA6340FCF5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIU6</accession>
    <name>A0A151MIU6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL34</name>
        <name evidence="6" type="ORF">Y1Q_0002062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006071">
        <property type="protein sequence ID" value="KYO24437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019355651.1">
        <property type="nucleotide sequence ID" value="XM_019500106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIU6"/>
    <dbReference type="STRING" id="8496.A0A151MIU6"/>
    <dbReference type="GeneID" id="102573335"/>
    <dbReference type="KEGG" id="amj:102573335"/>
    <dbReference type="CTD" id="6164"/>
    <dbReference type="eggNOG" id="KOG1790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MIU6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO24437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="117" mass="13309" checksum="FC11B00B98CB770C" modified="2016-06-08" version="1">MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGVRAVRPKVLMRLSKTKKHVSRAYGGSMCAKCVRDRIKRAFLIEEQKIVVKVLKAQAQSQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK14</accession>
    <name>A0A151MK14_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 41 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC41A3</name>
        <name evidence="11" type="ORF">Y1Q_0023739</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK14"/>
    <dbReference type="STRING" id="8496.A0A151MK14"/>
    <dbReference type="eggNOG" id="KOG3788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000002">
        <property type="entry name" value="Solute carrier family 41, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF22">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 41 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="50"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="263"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO24864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="423" mass="45252" checksum="BB7BAEBB4C46F255" modified="2016-06-08" version="1">MESGPGTKQRTRVLLPYMLAGLGMVLAGMVLDYVQHWDVFRTITEVFILVPALVGLKGNLEMTLASRLSTAANTGQMDDTQEQWKMATCNLALIQVQATVVGLLAAVAAVILGAISKGYVELNQAAVLCASSVTTAFIAALSLGLVMIGVIIGARKVGINPDNVATPIAASLGDLITLSLLAGISSTLFKYIDVKYLSPLICVGFIVMIPLWVAIAKQSPSLATVLKSGWQPVIVAMSISSIGGLILDKTVSDPKFEGMAVFTPVINGVGGNLVAIQASRISTFLHSWSSPGVLPHKMRQSWPNPFTTFFTSGVNSKSARVLFLLVIPGHLVFLYTIHLLQGGHMSITVTFVMFYLTAALMQVGILLYMADLIVRLMWKKALDPDNFSIPYLTALGDLLGTGFLALCFRLVWLIYGADTSLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLZ4</accession>
    <name>A0A151MLZ4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-aminobutyric acid type B receptor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GABBR1</name>
        <name evidence="13" type="ORF">Y1Q_0023976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005753">
        <property type="protein sequence ID" value="KYO25546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLZ4"/>
    <dbReference type="STRING" id="8496.A0A151MLZ4"/>
    <dbReference type="eggNOG" id="KOG1055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15291">
        <property type="entry name" value="7tmC_GABA-B-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000056">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002456">
        <property type="entry name" value="GPCR_3_GABA_rcpt_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="405"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="723"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO25546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="793" mass="90116" checksum="3C3BA8263E4A4FEF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNF8</accession>
    <name>A0A151MNF8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0003846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNF8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF22">
        <property type="entry name" value="PHOSPHOLIPID_GLYCEROL ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="141" mass="16199" checksum="59767D3D7AEEA7DC" modified="2016-06-08" version="1">MVQEGLLKEEQGSGVWPGNGQYARGPGETRVEWKRPPVRGESIIPMYTENIQEAYRMPNECRLIRWLHEAFLWPVIPPYGGLPVKLHTHVGEPIPYDPDITAEELAKKTQTALQNLIQRHQQIPGSMWKALLARLDKPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNZ9</accession>
    <name>A0A151MNZ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sialoadhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SIGLEC1</name>
        <name evidence="10" type="ORF">Y1Q_0000205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005607">
        <property type="protein sequence ID" value="KYO26271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MNZ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:clathrin-dependent endocytosis of virus by host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="sialoadhesin isoform X1"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="17"/>
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        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
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        <property type="entry name" value="SIALOADHESIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47243:SF1">
        <property type="entry name" value="SIALOADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="16"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="15"/>
    </dbReference>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="17"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="14"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585308" evidence="8">
        <location>
            <begin position="20"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1633"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
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    <feature type="domain" description="Ig-like" evidence="9">
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            <end position="507"/>
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    <feature type="domain" description="Ig-like" evidence="9">
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            <end position="591"/>
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            <end position="692"/>
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            <end position="775"/>
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            <end position="962"/>
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    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
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            <end position="1334"/>
        </location>
    </feature>
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        <location>
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            <end position="1439"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1441"/>
            <end position="1522"/>
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    <feature type="domain" description="Ig-like" evidence="9">
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            <end position="1630"/>
        </location>
    </feature>
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        <location>
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            <end position="1214"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO26271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1689" mass="182689" checksum="145D6C44DF31865B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQB6</accession>
    <name>A0A151MQB6_ALLMI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
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                <person name="Sanford J.R."/>
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                <person name="Guillette L.J.Jr."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="KYO26728.1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="8079" checksum="8E5732D50FB3160B" modified="2016-06-08" version="1">MQRICEYLFSGGISARGQQKSSITEQQRSKELFLQWGWELKRIISPTNLASQPGAPSSSRCCCHLNPTPGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSC7</accession>
    <name>A0A151MSC7_ALLMI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">Y1Q_0013455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
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                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
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                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
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                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
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                <person name="Guillette L.J.Jr."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KYO27431.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="8434" checksum="AF64496AE0CDDFEC" modified="2016-06-08" version="1">MSSQVKGLQIASSNIPPNPELSRGPAAAYQGRCTSHYQRCGVKDGGPNSWHPPHALPPTAGLDPAPGPGHHSGGAAGGLVGLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSQ6</accession>
    <name>A0A151MSQ6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Breast cancer anti-estrogen resistance protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CRK-associated substrate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">p130cas</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BCAR1</name>
        <name evidence="19" type="ORF">Y1Q_0003684</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSQ6"/>
    <dbReference type="STRING" id="8496.A0A151MSQ6"/>
    <dbReference type="eggNOG" id="ENOG502QQHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11569">
        <property type="entry name" value="FAT-like_BCAR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11552">
        <property type="entry name" value="Serine_rich_BCAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.830:FF:000001">
        <property type="entry name" value="BCAR1 scaffold protein, Cas family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000001">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000009">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.830">
        <property type="entry name" value="Serine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046976">
        <property type="entry name" value="BCAR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021901">
        <property type="entry name" value="CAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037362">
        <property type="entry name" value="CAS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014928">
        <property type="entry name" value="Serine_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038319">
        <property type="entry name" value="Serine_rich_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654:SF15">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654">
        <property type="entry name" value="CAS SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12026">
        <property type="entry name" value="CAS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08824">
        <property type="entry name" value="Serine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="88"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="702"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO27533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="960" mass="105625" checksum="B55BA1514E85473A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU87</accession>
    <name>A0A151MU87_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-dimethyl-L-lysine(36) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">KDM2A</name>
        <name evidence="25" type="ORF">Y1Q_0005094</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03005047">
        <property type="protein sequence ID" value="KYO28100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MU87"/>
    <dbReference type="STRING" id="8496.A0A151MU87"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21784">
        <property type="entry name" value="CTD_KDM2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22181">
        <property type="entry name" value="F-box_FBXL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15643">
        <property type="entry name" value="PHD_KDM2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000005">
        <property type="entry name" value="lysine-specific demethylase 2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000011">
        <property type="entry name" value="Lysine-specific demethylase 2B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="24">
        <location>
            <begin position="185"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="23">
        <location>
            <begin position="635"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="22">
        <location>
            <begin position="688"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="750"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="895"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="922"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO28100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1229" mass="140425" checksum="69C67B4433577A69" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUS6</accession>
    <name>A0A151MUS6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM98B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM98B</name>
        <name evidence="3" type="ORF">Y1Q_0015922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUS6"/>
    <dbReference type="STRING" id="8496.A0A151MUS6"/>
    <dbReference type="eggNOG" id="KOG3973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF11">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO28301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="341" mass="38444" checksum="0251AFA7E4481F03" modified="2016-06-08" version="1">MKELEPALRMEGDILDTLEALGYKGPLLEEEALNKAVENGLSSPEFFELCIWLSSQIKPLCDLEESITSAGEKDVESFQLEISGFLKEMACPYSVLVSGDVKDRLQKKEDCLKLLLFLSTELQALKILHNKQLKGSHLEKHNEIYHEVEAISDSLGLSKSSSSDMPLLLSNVESKIKDILSKIHSNHVGKPLLTTSLNPDQVERLEKINDALRSEYECRRRMLMKRLDVTVQSFGWSDRAKVKTDDIARIYQPKRYVLSPKSTITLAHLLAAREDLSKIIRTSSGSTREKTACAINKVLMGRVPDRGGRPTEIEPPPPEMPPWQKRQEGVGVVSGERVYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUV8</accession>
    <name>A0A151MUV8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">TRIM41</name>
        <name evidence="23" type="ORF">Y1Q_0010920</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03004973">
        <property type="protein sequence ID" value="KYO28229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUV8"/>
    <dbReference type="STRING" id="8496.A0A151MUV8"/>
    <dbReference type="GeneID" id="102574527"/>
    <dbReference type="KEGG" id="amj:102574527"/>
    <dbReference type="CTD" id="90933"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19760">
        <property type="entry name" value="Bbox2_TRIM4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000025">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM41 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="21">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="22">
        <location>
            <begin position="463"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="66"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO28229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="652" mass="73126" checksum="5BA675F79FD43CF9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVW8</accession>
    <name>A0A151MVW8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Interferon-induced very large GTPase 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0000807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004838">
        <property type="protein sequence ID" value="KYO28640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058641">
        <property type="entry name" value="GVIN1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057365">
        <property type="entry name" value="URGCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052986">
        <property type="entry name" value="VLIG_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14819">
        <property type="entry name" value="GTP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14819:SF9">
        <property type="entry name" value="UP-REGULATOR OF CELL PROLIFERATION-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25496">
        <property type="entry name" value="URGCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25974">
        <property type="entry name" value="URGCP_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25683">
        <property type="entry name" value="URGCP_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51717">
        <property type="entry name" value="G_VLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="VLIG-type G" evidence="4">
        <location>
            <begin position="928"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO28640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1888" mass="215804" checksum="6F3CF828FD7194A2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWL1</accession>
    <name>A0A151MWL1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWL1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="92" mass="10668" checksum="18463CDA218386CF" modified="2016-06-08" version="1">MVLLSFPPKTSKETIKYLFLSRNTERSYQPKGYNICKRMEALMKTPCRRLGLAFHLPVKIHEARLRSPSGISSEKEIKTDFTPIDTQTLRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWP2</accession>
    <name>A0A151MWP2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 68 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC68</name>
        <name evidence="2" type="ORF">Y1Q_0009762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006269718.2">
        <property type="nucleotide sequence ID" value="XM_006269656.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWP2"/>
    <dbReference type="STRING" id="8496.A0A151MWP2"/>
    <dbReference type="GeneID" id="102563190"/>
    <dbReference type="KEGG" id="amj:102563190"/>
    <dbReference type="CTD" id="80323"/>
    <dbReference type="eggNOG" id="ENOG502RXID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9391002at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051375">
        <property type="entry name" value="Tuftelin_GRINL1A/MYZAP/CCD68"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171">
        <property type="entry name" value="GDOWN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="339" mass="39100" checksum="243BADBC9205466A" modified="2016-06-08" version="1">MDGAGLSLPAEQHSARIMTTTLVLTERITREDRGSDGNYLLYGSSCAQISEETEYVKKVRSTLAKIQNQQPLQASDGTECEKDALSSSYDPIMAKMKETDKQLACISRENEILKIKLEATREAGAESLRHASRRLYENYQRRSEELKKGCEEDKRLMQASNIDREQKLKQNAENVSCLTERLEEKYSRIAEMERLVQRMEEEKKTLLEKKRSFEEMLLHMISNHEDAKRCVDLQEELFTLQQQIRHLQNLILFQNQDLRGAIQEIEELNRELKIQDKTIEDLKEKINMLEAQNKLLKYKVEVSSVQSTMKVSKAVSTDSTRIAGLSPYMMVASLQKQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWP7</accession>
    <name>A0A151MWP7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWP7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585524" evidence="1">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="81" mass="9058" checksum="D0F38121CDEB4198" modified="2016-06-08" version="1">MSNTSLLHYHQLMGQCHCLLHLLPLLGLDLALEETCGSYPVWQGSKARKESSRVQTLDFRKADMGTFGEAGNFYIKVMQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX12</accession>
    <name>A0A151MX12_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box only protein 4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FBXO4</name>
        <name evidence="2" type="ORF">Y1Q_0009855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX12"/>
    <dbReference type="STRING" id="8496.A0A151MX12"/>
    <dbReference type="eggNOG" id="ENOG502QUXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22085">
        <property type="entry name" value="F-box_FBXO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11656">
        <property type="entry name" value="FBX4_GTPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037657">
        <property type="entry name" value="RIMC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28494:SF1">
        <property type="entry name" value="RAB7A-INTERACTING MON1-CCZ1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28494">
        <property type="entry name" value="UPF0600 PROTEIN C5ORF51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17716">
        <property type="entry name" value="RIMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO29044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="625" mass="72477" checksum="5518B748BDF372C4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZ61</accession>
    <name>A0A151MZ61_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fibulin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0023186</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homotrimer; disulfide-linked. Interacts with LAMA2. Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZ61"/>
    <dbReference type="STRING" id="8496.A0A151MZ61"/>
    <dbReference type="eggNOG" id="KOG1217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00017">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000324">
        <property type="entry name" value="Fibulin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000341">
        <property type="entry name" value="Fibulin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000564">
        <property type="entry name" value="Fibulin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000578">
        <property type="entry name" value="Fibulin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000078">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000108">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000139">
        <property type="entry name" value="Fibulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF158">
        <property type="entry name" value="FIBULIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01821">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00104">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01177">
        <property type="entry name" value="ANAPHYLATOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01178">
        <property type="entry name" value="ANAPHYLATOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Anaphylatoxin-like" evidence="16">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphylatoxin-like" evidence="16">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="704"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO29846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112851" checksum="79D50014D00424F6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZH7</accession>
    <name>A0A151MZH7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibrous sheath-interacting protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0010242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004447">
        <property type="protein sequence ID" value="KYO29931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZH7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038891">
        <property type="entry name" value="FSIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031554">
        <property type="entry name" value="FSIP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21856">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21856:SF7">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15783">
        <property type="entry name" value="FSIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrous sheath-interacting protein 2 C-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO29931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="397" mass="43861" checksum="36657442BBD7D9D6" modified="2016-06-08" version="1">MDAEKTLLLKDATRKILLALQVLLSKEQVNMDKHISEHHLLHAEESQAIGHLFDSACSSTAQPADSGIFVGRDLTNQKDILAHRIAASIAKEVAKLEFQARSQDTSASITEGAKIVDKLPSDPGMITEIPKPAVNPHILMVPRMFVEEILSRFLPKVLISTNGRSLQHQRRLSRAEVNTLAENLNHVVEEGLSRHQISLVPATGEKPPLHPEQEGALIPGSRKYYLIMSQSSGSEQDLYDDVTGFDAHLHQDAVMVIIEELSNCPLLWVVSNRLSQSTTDPDRIANEALSQLSISAKSKSLRDEEAVPGTSADKTPTGTEELAMLRALQPKVDLLAQLAAHCTEDEEGEERVEDDLESEQQWEEEEELQQIEETAPVESSLCLWSPLGSFTDTEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N052</accession>
    <name>A0A151N052_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004278">
        <property type="protein sequence ID" value="KYO30181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N052"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="194" mass="20871" checksum="EE152C6717906614" modified="2016-06-08" version="1">MLGDHGPLPSQSTKEGTDASADILLSSASHNLKDIILDIFQLSHSLSFLGPQMLHPTELRGRGHRARLPAESHVPLQGSAPLSLSSTLSSVERNPEVLEVLYPASPFFPLIPEELQAASSDWEPASEMQKVNKGKTLRPRTPTTGNICSKPVPLMLSGGPCGKESVIFPLISTVFVTRISPLYLKAASDSFSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0P9</accession>
    <name>A0A151N0P9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">17-beta-hydroxysteroid dehydrogenase type 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0003341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004195">
        <property type="protein sequence ID" value="KYO30403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0P9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF4">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO30403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="208" mass="23074" checksum="F69333A20AECE271" modified="2016-06-08" version="1">MRGAQDKGRATELVLSELAQARVLNVNLVGLIEVTLSLLPLVRRARGRVVNVASIAGRLSLIGGGYCPAKYGVEAFSDSLRREVSNFGVKLSIIEPGGFRTQFLSSQHMLSNLEQVWSRVPAEVREAYGQQYFDHCFELTRKVLHMTCSDNLHLVTDAMEHALTAQHPRTRYSCGWDAKLLYLPLSYLPTSWADLVLTCSQPKPAQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N180</accession>
    <name>A0A151N180_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0008160</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N180"/>
    <dbReference type="STRING" id="8496.A0A151N180"/>
    <dbReference type="eggNOG" id="KOG1053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000344">
        <property type="entry name" value="Glutamate ionotropic receptor NMDA type subunit 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000020">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 2B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000009">
        <property type="entry name" value="Putative glutamate receptor ionotropic NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 18" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 18" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="19">
        <location>
            <begin position="336"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="20">
        <location>
            <begin position="344"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="17">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="17">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO30498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="636" mass="72073" checksum="D45D83BA1D56A6F1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N293</accession>
    <name>A0A151N293_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTPase IMAP family member 4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GIMAP4</name>
        <name evidence="8" type="ORF">Y1Q_0007707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004139">
        <property type="protein sequence ID" value="KYO30880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N293"/>
    <dbReference type="STRING" id="8496.A0A151N293"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF182">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="6">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="7">
        <location>
            <begin position="208"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="7">
        <location>
            <begin position="601"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="819"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO30880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="912" mass="102841" checksum="61CBE5A88DC0E8D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2D5</accession>
    <name>A0A151N2D5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TIMM50</name>
        <name evidence="14" type="ORF">Y1Q_0004971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004138">
        <property type="protein sequence ID" value="KYO30887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2D5"/>
    <dbReference type="STRING" id="8496.A0A151N2D5"/>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="13">
        <location>
            <begin position="128"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO30887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="338" mass="38576" checksum="4799F128C8290923" modified="2016-06-08" version="1">MTDALILKGLGLRLAIEVLRLTTEGGDGKDAGSDEQQEKKRKENIAYAKKVVLRLAGLMGAGSGLAIIYVFGSNSLDEHGAKIPDEFDNDPVVLQQVRRTHKYFKDYWQMIIEPMSPKLLPDPLKEPYYQPPYTLVIELIDVLLRPEWSLGTGWRFKKRPGIDSLLQQLAPLYEIVVFTSETGMTAFPLIDNVDPHGFISYRLFRDATHYVDGHHVKDISCLNRDPAKVVVVDCKKEAFHLQPFNGLALKKWDGNSEDRTLYDLTAFLKTIALSSVEDVRTVLENYSLEDDPLEAFKRRQSQLEQEEQQRLADLSRTKKQQLFLGSLTSRLWPRSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2E0</accession>
    <name>A0A151N2E0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">B9 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">B9D1</name>
        <name evidence="11" type="ORF">Y1Q_0014325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the tectonic-like complex (also named B9 complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the B9D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004153">
        <property type="protein sequence ID" value="KYO30805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N2E0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF1">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585668" description="B9 domain-containing protein 1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO30805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="165" mass="18436" checksum="C7B80D3F7927575E" modified="2016-06-08" version="1">MAAAASPSVFLLMVTGQIESAQFPEFDDLYCNTNPYGWPQIVLSVYGPDVFGNDVVRGYGAVHVPFTPGRHERTIAMFVPESTSKLQKFTSWLTGRRPEFTDPRVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLGLYLPFPRSSPSLHVNEIEELAARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4K3</accession>
    <name>A0A151N4K3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Citron Rho-interacting kinase</fullName>
            <ecNumber evidence="3 18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">CIT</name>
        <name evidence="27" type="ORF">Y1Q_0022808</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3 18"/>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019349281.1">
        <property type="nucleotide sequence ID" value="XM_019493736.2"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N4K3"/>
    <dbReference type="GeneID" id="102568242"/>
    <dbReference type="CTD" id="11113"/>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919042at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20814">
        <property type="entry name" value="CRIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05601">
        <property type="entry name" value="STKc_CRIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000234">
        <property type="entry name" value="Citron rho-interacting serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000081">
        <property type="entry name" value="Citron rho-interacting serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000224">
        <property type="entry name" value="Citron rho-interacting serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000018">
        <property type="entry name" value="Citron rho-interacting serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017405">
        <property type="entry name" value="Citron_Rho-interacting_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037708">
        <property type="entry name" value="CRIK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038145">
        <property type="entry name" value="Citron_Rho-interacting_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="97"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="26">
        <location>
            <begin position="361"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="1406"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="22">
        <location>
            <begin position="1487"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="25">
        <location>
            <begin position="1635"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1368"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1950"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="450"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1302"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1383"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="2002"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="2068"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO31718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2081" mass="238446" checksum="FF9D8B9D31AB06BE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N555</accession>
    <name>A0A151N555_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Disks large 1 tumor suppressor protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0003447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004037">
        <property type="protein sequence ID" value="KYO31891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N555"/>
    <dbReference type="STRING" id="8496.A0A151N555"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.470">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015143">
        <property type="entry name" value="L27_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09058">
        <property type="entry name" value="L27_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L27" evidence="1">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO31891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="9254" checksum="FA18D37ABCFACEE2" modified="2016-06-08" version="1">MPVRRKDTDRALQLLEEYCKKLKKPEEQQLKKAIKKVMGIFKSSLFQALLDITSVSQYILDEAALPKEEPPSADWRVAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5G8</accession>
    <name>A0A151N5G8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zona pellucida sperm-binding protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0022887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5G8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032190">
        <property type="term" value="F:acrosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035803">
        <property type="term" value="P:egg coat formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000344">
        <property type="term" value="P:positive regulation of acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4100:FF:000002">
        <property type="entry name" value="Zona pellucida sperm-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11576">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11576:SF14">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="36"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO31825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="475" mass="52697" checksum="C09E1BA6C56ED6A6" modified="2016-06-08" version="1">MREFKATGSCLSLKHSAFTSKRAGLVFPVLEFQLAVCWQLIVKMKSLADEPTNMPMHHLGHSKTCRMGFCGVVLLASLWVAVLGVPVTWELVSTRWNGSSYSTTAVPSATDPGLQNATKLSTKMSLFQKALNVSLTTALSASSKTTETSAPSGSSSTRVTSPSLTVVQAASHFLQSVYSMKSARMNFTLRILNKDFNIVDKTPVFRTGSPIHIEARVAANPNVSPKIYVDECYGAHSKHLSHSRRVYVIVNNRGCLYGGKSGNVSVWHRQADSALQFIIPAFLLGEEPEEEIYVHCLLTAWGQRTLSRHVKKSCYYNTASSSWQNLEDSSQNDLCNCCDSHCPFDFSPEEQEFPGEGMLHRKTVGPLTVHKEEAPWYEAQCRTMKKLVLAAIAFVGSCLLAALLVGGVIALGLALFHSYHHSKVPRLRRKRKPYPYHEELQTVVGALVPSEKIEKEKRELNAEYSNLKTEELEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6A2</accession>
    <name>A0A151N6A2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6A2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="76" mass="8023" checksum="5102048F811E4968" modified="2016-06-08" version="1">MTDRVPVLEPASVAGRKLLVPIGTVLFTFHVALSLLLWAKGKHALLLQESSLKAQPGANLVKEAEGTAFGWTGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6S4</accession>
    <name>A0A151N6S4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lymphokine-activated killer T-cell-originated protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PBK</name>
        <name evidence="7" type="ORF">Y1Q_0009024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003970">
        <property type="protein sequence ID" value="KYO32289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019348765.1">
        <property type="nucleotide sequence ID" value="XM_019493220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6S4"/>
    <dbReference type="STRING" id="8496.A0A151N6S4"/>
    <dbReference type="GeneID" id="102560641"/>
    <dbReference type="KEGG" id="amj:102560641"/>
    <dbReference type="CTD" id="55872"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14001">
        <property type="entry name" value="PKc_TOPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041989">
        <property type="entry name" value="PKc_TOPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF14">
        <property type="entry name" value="LYMPHOKINE-ACTIVATED KILLER T-CELL-ORIGINATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO32289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="325" mass="36259" checksum="DB738F9BEB81FECB" modified="2016-06-08" version="1">MDMESRRTPDGRGQRRKADAGPSSVVIPASPFMQKLGYGTGVNVYLMRRSPKGLSRSPWAVKKINPKCNTKQQNIYQERLNEEAKILKHLQHPNIVGYRAFAEASDGSMCLAMEYGGEKSLNDLIEERNDKNLGPFPAATILQVALNMARGLKYLHNDKKLLHGDIKSSNVVIKGDFEAIKICDVGVSLPLDENMTVSDPEARYIGTEPWKPKEALEEDGVITDKADIFAFGLTLWEMMTLSVPHVNLLMQDDDEEEDESFDEDDFDEDAYYAALGTRPPLNMEELDPSYQHAIELFSVCTSEEPAKRPSAAHIVTILEAGAQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7I1</accession>
    <name>A0A151N7I1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hypoxanthine-guanine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HPRT1</name>
        <name evidence="20" type="ORF">Y1Q_0009351</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25424"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:25426"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:17975"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7I1"/>
    <dbReference type="STRING" id="8496.A0A151N7I1"/>
    <dbReference type="eggNOG" id="KOG3367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000019">
        <property type="entry name" value="Hypoxanthine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050408">
        <property type="entry name" value="HGPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF6">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="19">
        <location>
            <begin position="41"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO32746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="317" mass="35711" checksum="A55F7D370962EB7C" modified="2016-06-08" version="1">MATPSPCIVIGDDEQGYDLDLFCIPKHYADDLEKVYIPHGLIMDRTERLAREIMKGMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDKSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMKTLLSLLKQYNPKMVKVASLLVKRTPRSVGYRPDFVGFEVPDKFVVGYALDYNEYFRDLNASTPKCQTWGSEHTSINVFEAFGDYSDSEGQRRTCRDKARERRGEGEDILCKDAGMQLGPRPERDNSGRGRSCVKTGEENGHVKRQRGCSNAAWAQSLPEKCFSYESEFLFQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7Z8</accession>
    <name>A0A151N7Z8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7Z8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="160" mass="17475" checksum="133DE74421A32E89" modified="2016-06-08" version="1">MAKAVDDEGLSGSNAGKAVFMNLDQTIRPTLLCEALRAQRERSTAATYLYRLRQRSACIVLISPISEGEVTFGRKRSGTSSKIQLFSYALHGLAALKTAWGNTPVLGLFGFTPPLESESWEIRGEVCRARAQSFPRSLRYSPKDVPAVSGKSHKNLSADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N971</accession>
    <name>A0A151N971_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MAGUK p55 subfamily member 4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MPP4</name>
        <name evidence="8" type="ORF">Y1Q_0008611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N971"/>
    <dbReference type="STRING" id="8496.A0A151N971"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06799">
        <property type="entry name" value="PDZ_MPP3-MPP4-MPP7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12034">
        <property type="entry name" value="SH3_MPP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035600">
        <property type="entry name" value="MPP4_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="363"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="596" mass="68295" checksum="61E47CDF67FEB7B0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9A5</accession>
    <name>A0A151N9A5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Bone morphogenetic protein receptor type-2</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Bone morphogenetic protein receptor type II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">BMPR2</name>
        <name evidence="34" type="ORF">Y1Q_0008621</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="25">On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="26">Interacts with GDF5. Interacts with BMP4. Interacts with SCUBE3. Interacts with TSC22D1/TSC-22. Interacts with activin A/INHBA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449673.1">
        <property type="nucleotide sequence ID" value="XM_014594187.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9A5"/>
    <dbReference type="STRING" id="8496.A0A151N9A5"/>
    <dbReference type="GeneID" id="102577319"/>
    <dbReference type="KEGG" id="amj:102577319"/>
    <dbReference type="CTD" id="659"/>
    <dbReference type="eggNOG" id="KOG3653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="669224at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005024">
        <property type="term" value="F:transforming growth factor beta receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001568">
        <property type="term" value="P:blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045778">
        <property type="term" value="P:positive regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014916">
        <property type="term" value="P:regulation of lung blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:regulation of multicellular organismal development"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:tissue development"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="STKc_BMPR2_AMHR2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFP_LU_ECD_BMPR2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
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        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0464">Manganese</keyword>
    <keyword evidence="18 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20 34" id="KW-0675">Receptor</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 32" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 31" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="32">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585850" description="Bone morphogenetic protein receptor type-2" evidence="32">
        <location>
            <begin position="20"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="33">
        <location>
            <begin position="207"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="854"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="854"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="868"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="901"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="923"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00057734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00063997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00073640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00077874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="KYO33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1041" mass="115540" checksum="7C68E3AEFC655856" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9S0</accession>
    <name>A0A151N9S0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UGT1A1</name>
        <name evidence="12" type="ORF">Y1Q_0008707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9S0"/>
    <dbReference type="STRING" id="8496.A0A151N9S0"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000001">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF161">
        <property type="entry name" value="UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007358837" description="UDP-glucuronosyltransferase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="328" mass="36647" checksum="219F3D00E53AE8E7" modified="2016-06-08" version="1">MAPVLLLRSQLAALFLFMMAGFLEEATSFASEILQRKVTMLDLLNPASILLLRYDFVFEYPRPVMPNMVFIGGINCAGKKALSEQFEAIVNASGEHGIVVFSLGSMVSEIPMKKAMEIAEALGKVPQTVIWRYTGEAPPNLSKNTKLVKWLPQNDLLAHPKTRAFITHGGSHGVYEGICNGVPMVLMPLFGDQMDNAMRVESRGAGVTLNILEMTSKDIADALNTVINDIRYKENIMRLSALHLDRPVHPLDLAVHWVEFVMRHKGAPHLRPAAHDLNWIQYHSLDVIAFLLAVVLITTFISFECCLFCCRKCFCKKGRDKSSKSKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NA32</accession>
    <name>A0A151NA32_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ANKRD2</name>
        <name evidence="6" type="ORF">Y1Q_0020566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003692">
        <property type="protein sequence ID" value="KYO33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NA32"/>
    <dbReference type="STRING" id="8496.A0A151NA32"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000093">
        <property type="entry name" value="ankyrin repeat domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="266" mass="29160" checksum="8EC1EF29EC765FB4" modified="2016-06-08" version="1">MAATVEQDLKWATELIDQRLAQEEAAKQSSSGQPPALVRMEVQELEDEKHQGALPLGIAVLKDAAVVPETFLRAAVRGQLRLVEKFLADGGSPDTCDEFHRTALHRASLEGHIEILEKLLEHGATVDFQDRLDCTAAHWACRGGHLAVVKLLQDHGANLNLVDKLLSTPLHVATRTGHADIAEHLIHVGVAINAVDREGDTALHDAARLNRYKIIKMLLLYGADMLAKNLAGKTPMDLVQLWQTDTRQALETPEQSRVEVDTEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAE7</accession>
    <name>A0A151NAE7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centrosome-associated FAM110 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0011220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003679">
        <property type="protein sequence ID" value="KYO33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAE7"/>
    <dbReference type="STRING" id="8496.A0A151NAE7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025740">
        <property type="entry name" value="FAM110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025739">
        <property type="entry name" value="FAM110_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14758">
        <property type="entry name" value="AGAP005440-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14758:SF4">
        <property type="entry name" value="PROTEIN FAM110A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14161">
        <property type="entry name" value="FAM110_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosome-associated FAM110 N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="110" mass="11821" checksum="115B45E2BFB03E1C" modified="2016-06-08" version="1">MPVETLRAGNAMKGVSSTAPFTSAMPFRILNKGPEYFRRQAETGARKPSAVERLEADKAKYVKSQQVASTKQEPVKPLVLKQPLFAPGPHALPQAREPLGHGAQVEGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBW4</accession>
    <name>A0A151NBW4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1</fullName>
            <shortName evidence="9">Oligosaccharyl transferase subunit DAD1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DAD1</name>
        <name evidence="11" type="ORF">Y1Q_0007740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003549">
        <property type="protein sequence ID" value="KYO34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBW4"/>
    <dbReference type="STRING" id="8496.A0A151NBW4"/>
    <dbReference type="eggNOG" id="KOG1746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="12113" checksum="24348E99EA217823" modified="2016-06-08" version="1">MSGAGSGPGAAAGPGAGGGSVGSVVRRFLAEYASGTPSRLKVLDAYLLYVLLTGALQFGYCLGVGTFPFNSFLSGFISAVGSFILGVCLRIQINPQNKGEFQGISPERAIRILFPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBZ1</accession>
    <name>A0A151NBZ1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="11">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">COG6</name>
        <name evidence="16" type="ORF">Y1Q_0007613</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for normal Golgi function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Golgi apparatus membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003532">
        <property type="protein sequence ID" value="KYO34338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBZ1"/>
    <dbReference type="STRING" id="8496.A0A151NBZ1"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="14">
        <location>
            <begin position="60"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="15">
        <location>
            <begin position="205"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO34338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="657" mass="73526" checksum="C64700C8B395148D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NC76</accession>
    <name>A0A151NC76_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0010241</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003480">
        <property type="protein sequence ID" value="KYO34422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NC76"/>
    <dbReference type="STRING" id="8496.A0A151NC76"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000895">
        <property type="entry name" value="Zinc finger protein 597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000292">
        <property type="entry name" value="zinc finger protein 619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002604">
        <property type="entry name" value="Zinc finger protein 715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000873">
        <property type="entry name" value="Zinc finger protein 841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002196">
        <property type="entry name" value="zinc finger protein 850-like isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF260">
        <property type="entry name" value="ZINC FINGER PROTEIN 383-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO34422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="503" mass="56449" checksum="9621A8764E6D687D" modified="2016-06-08" version="1">MRPKQKGNAREGLTARSPGGEQRVGDRGRSLTAQAPSGKGEVTVNVKVKEVASHEMQTSGALQQPGDPWPEQARAQTADVPLEEAAQRDSPGPRDQPPRSPREEPMLDLESGTVRKAHQQPPEEGPANLELPRSTPGRLGERGSLRPEGIQLQQGQGRLAMQVESTELQEAFEDVAVYFTREECPECGKNFTRSSHLTLHRRIHKVKKPHQCSECGKSFTYSSHLVRHQRFHTGQKPYQCPECGKSFTHSSHLVRHQRIHTGEKPYQCSECGKSFTQSYNLAQHQRIHTGEKPYHCSACGKSFNQSSHLAQHQRLHTGDKPYQCSVCGKSFTQSYNLAQHQRVHTGDKPYQCPECGKSFTYSFSLATHQRLHTGEKPHQCPECGKTFTYSSVLARHQRIHTGKKPHQCSVCGKSFTQSSHLAQHQRIHTGEKPYQCSECGKSFTQSFSLATHQRMHTGQKPYQCPECGKSFTHSSILVRHQHIHTRKKLHQCSVGRALPSPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCE3</accession>
    <name>A0A151NCE3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4E-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EIF4EBP1</name>
        <name evidence="5" type="ORF">Y1Q_0018158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003560">
        <property type="protein sequence ID" value="KYO34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266206.1">
        <property type="nucleotide sequence ID" value="XM_006266144.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCE3"/>
    <dbReference type="STRING" id="8496.A0A151NCE3"/>
    <dbReference type="GeneID" id="102575532"/>
    <dbReference type="KEGG" id="amj:102575532"/>
    <dbReference type="CTD" id="1978"/>
    <dbReference type="eggNOG" id="ENOG502S4SY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19729at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NCE3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669:SF14">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="11906" checksum="B5867C56EF76E9A4" modified="2016-06-08" version="1">MAVPGSCLPGQTPSRDIPAPSGAPRLPPGNYSSTPGGTVFGTTPGGTRIIYDRKFLMECRNSPVAKTPPCDLPDIPGVTSPNVEELKIENNHVHNYEEKVGAGEEAQFDMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEJ9</accession>
    <name>A0A151NEJ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Intraflagellar transport 74-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IFT74L</name>
        <name evidence="2" type="ORF">Y1Q_0001080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEJ9"/>
    <dbReference type="STRING" id="8496.A0A151NEJ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="117" mass="13678" checksum="EA8E06B5B8F020D5" modified="2016-06-08" version="1">MKTGMKGPQRQIMDKSYYLGLLRSKISELTTEINKLQKEIEMYNQENSVYLSYEKRAEALAGEIKEFQGQLADYNMLVDKLNTNTDMEEVMNDYNTLKTQNDLESQSMDIIFTERQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFY8</accession>
    <name>A0A151NFY8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OCA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0010162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFY8"/>
    <dbReference type="STRING" id="8496.A0A151NFY8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070974">
        <property type="term" value="F:POU domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047571">
        <property type="entry name" value="OCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF8">
        <property type="entry name" value="OCA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52003">
        <property type="entry name" value="OCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCA" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO35723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="365" mass="41094" checksum="01D91C1CEEB8F8B4" modified="2016-06-08" version="1">MSALTDPGLSADPPQRQYVGVRVRLPVRELLRKIRLSKGMDPNDTKDEQQTKVTKGCPGRCSGRAEKRRAHPYTDKQLRQSKNCSGKARKALEDLDILVEFQLQREENLLRNIPVDKLLAPDENGNRLLHKAVTQGKRALAYALARKYACLNKIDEKDAAKRTALHLAVEKNQHLMASDLISLGANINEQDSLGKTPLHLCAENGYLRVLEVLRNYKARGLQVEVNAPDHYGLTPLHCAAHAHTILMVESQRNNITTDARRFLKLRRDQILEGISCLLQMGADRGLQILKSYQTATSYLKAQENHELMLFLQSHSHMRQDFSQEGCSLPSSPRGMIFPDLPEEVSELLPTLNACSQMFDKKGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK52</accession>
    <name>A0A151NK52_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G patch domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GPATCH3</name>
        <name evidence="3" type="ORF">Y1Q_0023081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002882">
        <property type="protein sequence ID" value="KYO37059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014465994.1">
        <property type="nucleotide sequence ID" value="XM_014610508.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK52"/>
    <dbReference type="STRING" id="8496.A0A151NK52"/>
    <dbReference type="GeneID" id="102562492"/>
    <dbReference type="KEGG" id="amj:102562492"/>
    <dbReference type="CTD" id="63906"/>
    <dbReference type="eggNOG" id="ENOG502QQ66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5842926at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040341">
        <property type="entry name" value="GPATCH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14390:SF2">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="377"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO37059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="491" mass="55628" checksum="0D4AD471593D1FE8" modified="2016-06-08" version="1">MAAPSTEGPAQYCLVSRVPAALRSPQLRAYFSQFLEAGGFLCFHYRHRPERAAPAGQGPAPPPPTCCCLVAVRPGQAARLVRMYSGRRWLGPRGEALPGRCLIRRVRVAPDADVDTFTYKTKKELQSKTQSETFTQTDLKWLPELNPPAFMPQGNVGTPLSVFLELIRTCRLPPRVIKKLQLNFPKTGSSRRYGNVPFKYQDTETFAQELVYTAAGDEITEESEPVISSGVSDQTHDDDDDGIGERSGKEKSEESHSDDDDDRCEEWERHEALHEDVTKQERAEERLYEEEIELKWEKGGSGLVFYTDAQYWQEEKGDFDEQTADDWDVDMSIYYDQDGGDKDARDLMQMRLEQRLRDGLEDESIAGQRIGTFEKYTKGIGRKVLERQGWMEGQGLGSSTSGMAEALDNEGQNPRCKRGLGYHGEKLQTFSKAKKPRPDSHILISTVYDEPQPQDTWDELFRCQPPTAMKYRRDMAFVRETHSAQKSPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKC4</accession>
    <name>A0A151NKC4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 6 isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TTC6</name>
        <name evidence="6" type="ORF">Y1Q_0008936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002792">
        <property type="protein sequence ID" value="KYO37237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NKC4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="586"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="756"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="894"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1212"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1246"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1384"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1418"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1486"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="557"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO37237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1556" mass="178373" checksum="E6AAD503C3D00AD1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKR6</accession>
    <name>A0A151NKR6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKR6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO37396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="117" mass="13205" checksum="E4D855A2EFD69333" modified="2016-06-08" version="1">MRAEAVCTLQIRFCVNINDIDCKPRKDCNKELPLLFTITKELIHGACETRRAEVFQDSALITKLGKDILYLSDEAEPISKWIARVLGAAEEQARLDMTLFDDSGLQHLEEMSPGPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMZ8</accession>
    <name>A0A151NMZ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA wybutosine-synthesizing protein 2 homolog</fullName>
            <ecNumber evidence="2">2.5.1.114</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRMT12</name>
        <name evidence="11" type="ORF">Y1Q_0007279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019343554.1">
        <property type="nucleotide sequence ID" value="XM_019488009.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMZ8"/>
    <dbReference type="STRING" id="8496.A0A151NMZ8"/>
    <dbReference type="GeneID" id="102563349"/>
    <dbReference type="CTD" id="55039"/>
    <dbReference type="eggNOG" id="KOG1227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000002">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056745">
        <property type="entry name" value="TYW2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25132">
        <property type="entry name" value="TYW2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="10">
        <location>
            <begin position="102"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO38168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="421" mass="47286" checksum="C36CAC457391D7D2" modified="2016-06-08" version="1">MREYLEGARILNVSHRVQKLPDGTVALPVLEGKLTKQHLQDLRGSMAPGTTCILSWIKKPIPSKAARAQSPAQKLCGELQHLVARFGGRWSEELEHDLPHSWQRHGDLVMLSKDCFKAALWEELGPELWETVASSLKARRLAKQGRVSPDGVRTPTVSLLLGHDGWVEHMDNGIRYTFDVTRCMFSSGNITEKLRVASLQCPREVLVDLYAGIGYFTLPFLVHAGVAFVHACEWNPHAVEALRRNLELNGVQDQCWIHPGDNRQLELRDVADRVNLGLIPSSEQGWPIACQVLRKDTGGILHIHQNVESFPAKALQLPCGLLKEQSLCNGQEDSGAQRNHGSPETADVMDSVQKIQFTGTRPEWQRWAEATGAQIRFLLEKLHGEPWRINILHIKPVKSYAPHVHHLVLDLECRPLQAEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNX5</accession>
    <name>A0A151NNX5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNX5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="144" mass="16358" checksum="2A9D969BFC86ADF3" modified="2016-06-08" version="1">MWGKDGGLTHKPPVPRPAPGTEHLISEMLQTLTKRLSHSSSGPESVFSGDASSGSPPPTARALKKCQICQRCMMDQTLLQLLVEVMEEWEENARAWQVEDISGEEAQDWHREEWDWTSWEFRAELLALECEQIQVLQEQNTILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPK8</accession>
    <name>A0A151NPK8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPK8"/>
    <dbReference type="STRING" id="8496.A0A151NPK8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23404" checksum="1B47D9A57C9C9DDF" modified="2016-06-08" version="1">MTSFGTTKDIRESGYMPTFKVQGQVYHRNDKGLPNEERKFLQIYFMGDNTKQAEQRCNNVIQTNLQVVLQLQDMLHKENNYVHSFKRAMKKMTPEYNVVIDADKTPAGEHEQCFNAPTTSEAAVILAGEQHGSRDIVLQLRNNSLQRIAEMHQSDDALQYPLIFWQGDDSYHFELRQTNRATGLPTQKTISAMDFYAYRMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPN9</accession>
    <name>A0A151NPN9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPN9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="7741" checksum="252865FC2C64D633" modified="2016-06-08" version="1">MESLTARKSLLSLLAKITSLSCSLELSKGCQASSEGPVDLLACPGDCNIYHDCKLVRFSSCLTTDFVGRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQA7</accession>
    <name>A0A151NQA7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQA7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11816" checksum="FDE0882F779C4D15" modified="2016-06-08" version="1">MEKDQGQDIPGLPGFISQYSKTSKAFQNRAHLEKKRSHLESPNILSVQFSTAQRTTAPLLMSATKQLSHPEDYPYISAHKILEMEKYLIWSVFLPVQNYSLMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQW1</accession>
    <name>A0A151NQW1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA (Cytosine-5)-methyltransferase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DNMT3L</name>
        <name evidence="7" type="ORF">Y1Q_0000103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002379">
        <property type="protein sequence ID" value="KYO39090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQW1"/>
    <dbReference type="STRING" id="8496.A0A151NQW1"/>
    <dbReference type="eggNOG" id="ENOG502SIGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040552">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049554">
        <property type="entry name" value="DNMT3_ADD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF13">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17980">
        <property type="entry name" value="ADD_DNMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21255">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO39090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="387" mass="44273" checksum="4D6EF6B40EA691EF" modified="2016-06-08" version="1">MAQVVFLSDTDSTEDLEEGLPSLADMAASLEKDSTSDVVSLGSVEEITSPNRDHIVHEVIKNQRSIEEICICCGSFKVHTQHPLFHGGICSLCTENFLETFFLYDDDGLQSYCTICCSGKILLMCDEPTCNRGYCFKCLDVLVSPGTAEKVKAMNTWLCFMCLPLSSHGLLQKKQRWRTRLKCFYDQESNEDRAPNATTKQSISNLHSSEMKSIGFLDSSLGNGRLKYLHDVTNILRMNVKEWGPFDFIFGSTPPVGNSYDHPPAWYFYQYYRILQYGKPLENSERPFFWMFVDNLVLTEEDRDTASRFFKTEAVTVHREHGETIQNAVIIWSNIPSVKSKYSLSDLNVDLHLLAKNIIRKRILSQQPATLVKKFFLPLKEYFKCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NR92</accession>
    <name>A0A151NR92_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4F2 cell-surface antigen heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SLC3A2L</name>
        <name evidence="5" type="ORF">Y1Q_0003934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002234">
        <property type="protein sequence ID" value="KYO39377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NR92"/>
    <dbReference type="STRING" id="8496.A0A151NR92"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904273">
        <property type="term" value="P:L-alanine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903801">
        <property type="term" value="P:L-leucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015823">
        <property type="term" value="P:phenylalanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042280">
        <property type="entry name" value="SLC3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673:SF1">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Solute carrier family 3 member 2 N-terminal" evidence="4">
        <location>
            <begin position="65"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="140"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO39377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="221" mass="23706" checksum="004E527480F38B71" modified="2016-06-08" version="1">MLAGCGDHLGARRSVPPSTAMEADLKDVELNELEPEKQPMTPASPGSPEKNGAVKVKVAEDEEDEGAPKFTGLSKEELLRAAGTPGWVRARWALLILFWLGWLGMLAGAVLIIVQAPRCRPLPPQTWWHKGGLYRIQPMEAFRDSKGGNAGDLAGVKEKLDYVAALGVQGLVLGPLHDTKRDSPKDTNLQKLHPQLGSNETLAQLLEAAKKKGKVGGGVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUK2</accession>
    <name>A0A151NUK2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol 1,4,5-trisphosphate receptor-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ITPRIP</name>
        <name evidence="17" type="ORF">Y1Q_0009622</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus outer membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ITPRIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006268677.1">
        <property type="nucleotide sequence ID" value="XM_006268615.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019341530.1">
        <property type="nucleotide sequence ID" value="XM_019485985.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUK2"/>
    <dbReference type="STRING" id="8496.A0A151NUK2"/>
    <dbReference type="GeneID" id="102563982"/>
    <dbReference type="KEGG" id="amj:102563982"/>
    <dbReference type="CTD" id="85450"/>
    <dbReference type="eggNOG" id="ENOG502QRDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9923553at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NUK2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000008">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026250">
        <property type="entry name" value="ITPRIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF8">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02107">
        <property type="entry name" value="INOS145TPRIP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012610628" description="Inositol 1,4,5-trisphosphate receptor-interacting protein" evidence="15">
        <location>
            <begin position="16"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="16">
        <location>
            <begin position="404"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO40611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="549" mass="63334" checksum="C5DCD2F3863938C5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUR9</accession>
    <name>A0A151NUR9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium/iodide cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0013883</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71207"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001895">
        <property type="protein sequence ID" value="KYO40672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUR9"/>
    <dbReference type="STRING" id="8496.A0A151NUR9"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008507">
        <property type="term" value="F:sodium:iodide symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904200">
        <property type="term" value="P:iodide transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF11">
        <property type="entry name" value="SODIUM_IODIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO40672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30801" checksum="2E83414A972024C6" modified="2016-06-08" version="1">MEVFRPEMLTFSLWDYGVFGLMLLVSTAIGLFYALAKGGQKTSEDFFMGGRQMPAVPVGLSLSASFMSAVQVLGVPAEAYRYGLKFLWMCLGQALSTLLTAFVFLPVFYRLGLTSTYEYLELRFSKEVRLCGTVQYIAATVLYTGIVIYAPALILNQVTGLDIWASLLSTGAVCTFYTTIGGMKAVVWTDVFQMFVMLSGFVAIAIQGTLMVGSPGGVLGAAYNHSRVNFADFDPDPRSRYTFWTFLFGGTLVWLSMYSVNQAQVQRYVACRTECEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX74</accession>
    <name>A0A151NX74_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Interleukin-1 receptor type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">IL1R1</name>
        <name evidence="19" type="ORF">Y1Q_0006221</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX74"/>
    <dbReference type="STRING" id="8496.A0A151NX74"/>
    <dbReference type="eggNOG" id="ENOG502QWEU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004909">
        <property type="term" value="F:interleukin-1, type I, activating receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000002">
        <property type="entry name" value="Interleukin 1 receptor accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001302">
        <property type="entry name" value="Interleukin 1 receptor like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000188">
        <property type="entry name" value="Interleukin-1 receptor accessory protein-like 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004076">
        <property type="entry name" value="IL-1_rcpt_I-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004074">
        <property type="entry name" value="IL-1_rcpt_I/II-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041416">
        <property type="entry name" value="IL-1RAcP-like_ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF26">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18452">
        <property type="entry name" value="Ig_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01538">
        <property type="entry name" value="INTRLEUKN1R1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01536">
        <property type="entry name" value="INTRLKN1R12F"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="11 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586457" evidence="16">
        <location>
            <begin position="29"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="140"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="17">
        <location>
            <begin position="384"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="505"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="629"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="700"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="17">
        <location>
            <begin position="849"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO41398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1039" mass="120164" checksum="CF3EFA4D2FF74703" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY97</accession>
    <name>A0A151NY97_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glucagon receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GCGR</name>
        <name evidence="21" type="ORF">Y1Q_0017397</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001558">
        <property type="protein sequence ID" value="KYO41851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059587887.1">
        <property type="nucleotide sequence ID" value="XM_059731904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY97"/>
    <dbReference type="STRING" id="8496.A0A151NY97"/>
    <dbReference type="GeneID" id="106737021"/>
    <dbReference type="KEGG" id="amj:106737021"/>
    <dbReference type="CTD" id="2642"/>
    <dbReference type="eggNOG" id="KOG4564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004967">
        <property type="term" value="F:glucagon receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15267">
        <property type="entry name" value="7tmB1_GCGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000009">
        <property type="entry name" value="Glucagon receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000133">
        <property type="entry name" value="Glucagon receptor a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003290">
        <property type="entry name" value="GPCR_2_GLP1/glucagon_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003291">
        <property type="entry name" value="GPCR_2_glucagon_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF29">
        <property type="entry name" value="GLUCAGON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01353">
        <property type="entry name" value="GLUCAGNFAMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01354">
        <property type="entry name" value="GLUCAGONR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586480" description="Glucagon receptor" evidence="18">
        <location>
            <begin position="23"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="19">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="20">
        <location>
            <begin position="137"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="464"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO41851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="499" mass="57265" checksum="2219941248C03F06" modified="2016-06-08" version="1">MSRRRLLALLLALLSHCQGPSAQVTDFLFERWQAYREECHHNMSLQPPPTELVCNRTFDNFSCWPDTLPNATINASCPWFLPWHRKVKHRYVFKTCGPDGQWLKGPKGQSLRDATQCEMDPEDLKAQDKFAKTYGSFKIMYTVGYSVSLGTLLLALTILLGFSKLHCMRNYIHMNLFASFVLKGISVLVIDALLKTRYSEEIDGYNVGTWFSDEAAAGCRAATVFMQYGIVANYCWLLVEGIYLHNLLVLAVFSERSYFTLYLCIGWGAPILFLVPWVVVKFLYENIQCWSTNNNMGFWWILRFPVFLAILINFFIFIRIIQILVSKLRAHQMRYTDYKFRLAKSTLTLIPLLGIHEVVFAFVTDEHAQGTLRYVKLFFDLFLSSFQGMLVAILYCFVNKEVQAELLKRWQRWKLGKDLAEEYKHTYSHTPQPRGGGSTCEKHRLVSYINGGRGLPTAHTSSHYLERTGASPSPSPSESLTPGQRQLAYDFPGVAESTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYE5</accession>
    <name>A0A151NYE5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alpha-mannosidase</fullName>
            <ecNumber evidence="17">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MAN2A1</name>
        <name evidence="20" type="ORF">Y1Q_0011204</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:56052"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28729"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="3.2.1.114"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="17"/>
    <dbReference type="EMBL" id="AKHW03001537">
        <property type="protein sequence ID" value="KYO41896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYE5"/>
    <dbReference type="STRING" id="8496.A0A151NYE5"/>
    <dbReference type="eggNOG" id="KOG1958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11667">
        <property type="entry name" value="GH38N_Man2A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000009">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000002">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF57">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="19">
        <location>
            <begin position="512"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO41896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1161" mass="131618" checksum="800E53887FF46FF3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYH0</accession>
    <name>A0A151NYH0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane-spanning 4-domains subfamily A member 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MS4A15L</name>
        <name evidence="7" type="ORF">Y1Q_0006440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYH0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF155">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO41700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="219" mass="24144" checksum="20BBD1876D927945" modified="2016-06-08" version="1">MQSREQPPGAVASENHPALIAVPAANMPLKHRKTSPRSALKILGVLQIVTGLIHVGFGSVLVSLIKTHTWLLSMASHYLYWGGLCFVISGSFTTAAEKYRKTSLVNSSLFMNAVSVLASAAGGVLMSWDFILSDDFYYSPTLNADLRMAKGLVSILMIFTLLEFCLTVSSFHLGCRSWSEKALYFDPDEFNCDLKHTLKVKSHPSTYSNEGYDLDRQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZ51</accession>
    <name>A0A151NZ51_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0022515</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001509">
        <property type="protein sequence ID" value="KYO41920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZ51"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000196">
        <property type="entry name" value="Zinc finger protein 1026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001906">
        <property type="entry name" value="zinc finger protein 425"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO41920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="349" mass="39732" checksum="1C650F7D8F6A0266" modified="2016-06-08" version="1">MHSGDQPRLCPECGKSFVSLSDLRGHQGMHAGELLYHCAECKKGFSRWDHLQNHTCIHVGKKPFSCPQCGKRFTWSSKLIRHLRVHTGEKPFSCIECGKSFTQMEKLTNHLRVHTGEKPFTCLQCGKSFTQMEKLTNHQRVHTGEKPFSCSQCRKSFTQSSHLTKHLRVHTGEKPFSCNQCRKSFTQSDKLTNHLRVHTGEKPFSCIQCRKSFTQSFTLTQHLRMHTGEKPFSCPQCGKSFTDHSMLTQHQRRHTGEKPFSCGQCGKSFMQSSHLTVHLRMHTGEKPFSCLQCGKNFTRSSTLTSHLRLHSGEKPFSCGQCGKSFTQNSHLTRHLRVHPGGEVVLVQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZE5</accession>
    <name>A0A151NZE5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001472">
        <property type="protein sequence ID" value="KYO42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZE5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="13110" checksum="40531A417C6FB15D" modified="2016-06-08" version="1">MLLPVSTPFAWDVPRSAQAVVRVLSWGLASLLHVAVLTHTLYYLLVFSLVPGVALYEHVVPAVLRFLEALEPVADIFFQDVLRALGIVLASLLLPGSLFFFLKLVLLPLSYHLARLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZQ2</accession>
    <name>A0A151NZQ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor JunB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcription factor AP-1 subunit JunB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">JUNB</name>
        <name evidence="12" type="ORF">Y1Q_0015231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001482">
        <property type="protein sequence ID" value="KYO42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZQ2"/>
    <dbReference type="STRING" id="8496.A0A151NZQ2"/>
    <dbReference type="eggNOG" id="KOG0837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14696">
        <property type="entry name" value="bZIP_Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000012">
        <property type="entry name" value="Putative transcription factor AP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005643">
        <property type="entry name" value="JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF37">
        <property type="entry name" value="TRANSCRIPTION FACTOR JUNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03957">
        <property type="entry name" value="Jun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="213"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="218"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="292" mass="31515" checksum="1AA22CDC0D7B8CCC" modified="2016-06-08" version="1">MEQPFYHDDSFLTGYGRAELGSHADYKPYRALKAQLQLRAGAEEGGGAFYAPAGLGEAGSASLKLASPELERLIIQNSNGVVTTTPTPPGQFFYPRGPTEEQEGFADGFVKALDDLHKLNHLPPPNVSLGAAPASSAYAPALHPEPAPVYTTLTSYPPPAAATAYPSANLSYLPPGYPRPQGFKEEPQTVPEPPAPAPGSPPLSPIDMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEEKVKSLKAENAGLSSTAGLLRDQVAQLKQKVLTHVNSGCQLLLAVKMQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0E2</accession>
    <name>A0A151P0E2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hematopoietically-expressed homeobox protein HHEX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hematopoietically-expressed homeobox protein hhex</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HHEX</name>
        <name evidence="15" type="ORF">Y1Q_0022164</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0E2"/>
    <dbReference type="STRING" id="8496.A0A151P0E2"/>
    <dbReference type="eggNOG" id="KOG0483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000178">
        <property type="entry name" value="hematopoietically-expressed homeobox protein HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="139"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO42299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="218" mass="25165" checksum="57CDDDA2F523E8BE" modified="2016-06-08" version="1">MEPGRPQDERTPIYEPTPIHPAFSPHPAAALAATYGSSTYAGPLYPFPRTVTDYTHALIRHDPLGKPLLWSPFIQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQASKKEEAESVDSHCDQRQESCLSPEQKNKDVSLDGSQYTPSPVSQEDLESEISEDSDQEVDIEDDKGYYNSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0V7</accession>
    <name>A0A151P0V7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0V7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="15980" checksum="26158D16E9463749" modified="2016-06-08" version="1">MRMRARAGCPVRPAPPRPGGGSEEQRPRNKARPEPVAGTEGFGDGSCRGGASRPHALRGFARARLSTRFSLKVKIPADCRTQVAKTVNDIKRFILRSDVRVYFLLYCVRGSWTIHQQTKPGIYPAFETGLMELCGDHPFSLGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0X1</accession>
    <name>A0A151P0X1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">V-set and transmembrane domain-containing protein 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">VSTM2A-1</name>
        <name evidence="14" type="ORF">Y1Q_0016148</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001351">
        <property type="protein sequence ID" value="KYO42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0X1"/>
    <dbReference type="GeneID" id="102576871"/>
    <dbReference type="CTD" id="222008"/>
    <dbReference type="OrthoDB" id="8956829at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P0X1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090336">
        <property type="term" value="P:positive regulation of brown fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070352">
        <property type="term" value="P:positive regulation of white fat cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000530">
        <property type="entry name" value="V-set and transmembrane domain containing 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051102">
        <property type="entry name" value="IgSF_V-set/TM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207">
        <property type="entry name" value="V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12207:SF23">
        <property type="entry name" value="V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586574" description="V-set and transmembrane domain-containing protein 2A" evidence="12">
        <location>
            <begin position="25"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="240" mass="26623" checksum="8C99C87794A8B351" modified="2016-06-08" version="1">MMGIFLAYVGFIFFSVMYIQQGLSTQAKFTEFPRNVTATEGQNVEMSCAFQSGSASVYLEIQWWFLRAAEDQEAGAEVTGTQVELLPERDLDNDGTKISTVKVQGNDISHKLQISKVRKKDEGLYECRVTDANYGDLQEYKAQAFLKVNANSHSRRMQAFEASPMWLQDVKPRKNISAAVPSSNHNSANQRVRSTSSPEAAAKIPKQSPQSAKSKSPVKSTERTAKLTLTSNHHSAPNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1W3</accession>
    <name>A0A151P1W3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001328">
        <property type="protein sequence ID" value="KYO42889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1W3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="98" mass="10891" checksum="640CA835906BF04F" modified="2016-06-08" version="1">MIQADSENRHEKTSPEKTEKADSRGPSPRRSARSSTHPPRGAAAQSWLAKKLPRQLELLRHPQKSRKTTTAAAAKWQTIELESTGGERKAVFQGEFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P397</accession>
    <name>A0A151P397_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P397"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO43450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="209" mass="22947" checksum="AFCDBFAEDEA64BCE" modified="2016-06-08" version="1">MKSYYSFAEDLPKGGETTAELRGNHPPSSGFVLPALGIQKQALPIPMKSAPPPSFGTTPVYYFSFLQLKHLVAILLDPQLLFAQSFLLSSLAVAWTLVLIPLKKRSVPGGFHIQTTPSRHKAWSYEEHFGSSDPSTSTPWVIKLCLHLDMMISANWCTLIGRKEYHQYTQSPPTNNHEVNSSGKGDGNCVPNTIMAEGSSCSLNSRTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3S7</accession>
    <name>A0A151P3S7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC35B2</name>
        <name evidence="9" type="ORF">Y1Q_0013477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3S7"/>
    <dbReference type="STRING" id="8496.A0A151P3S7"/>
    <dbReference type="eggNOG" id="KOG1581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO43405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="450" mass="50005" checksum="B26AC264AE57A06E" modified="2016-06-08" version="1">MAARQPEEQLPQVTWDIQNKLYLAVMLAALPPMAASEAVPAALQDTWGDFWLFRFFINAAGYASILVPGYLLIQYFKRKNYLETGRGICFPVIKSCVFGSEAKSAHQDDISLAARSEPMESSTARQVFKLLFCAVGLQVSYLTWGVLQERVMTRTYGATETEPGEKFKDSQFLVFMNRILAFTVAGLYCALTKQPRHGAPMYKYSFASLSNILSSWCQYEALKYISFPTQVLAKASKVIPVMLMGKLVSRKSYEYWEYLTAALISVGVSMFLLSSAPNKHLSTVTTFSGLVLLAGYIVFDSFTSNWQDALFTYKMSPVQMMFGVNVFSCLFTMGSLLEQGALVESARFMARHSEFTVHAVLLSVCSACGQLFIFYTISQFGAAVFTIIMTLRQAFAILLSCLIYGHAVTVVGGLGVAVVFVALFLRVYARSRVKKRSKKLPPGDAPIQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P481</accession>
    <name>A0A151P481_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CUB and zona pellucida-like domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CUZD1</name>
        <name evidence="9" type="ORF">Y1Q_0012832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001049">
        <property type="protein sequence ID" value="KYO43858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P481"/>
    <dbReference type="STRING" id="8496.A0A151P481"/>
    <dbReference type="eggNOG" id="ENOG502RSDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4100:FF:000005">
        <property type="entry name" value="Deleted in malignant brain tumors 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000004">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF27">
        <property type="entry name" value="CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="36"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="153"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="8">
        <location>
            <begin position="276"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO43858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="605" mass="67779" checksum="090B7068A9305AA2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6G7</accession>
    <name>A0A151P6G7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000701">
        <property type="protein sequence ID" value="KYO44613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6G7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9660" checksum="D34288C70D3E1917" modified="2016-06-08" version="1">MGNYNSRKKVKTIKQDKKEKCPDQEKDKEKWRHVIYLKKNKSTVKVLLLPPLGKLTHGPKTLSLIAPPGSNVNIFNRSELGSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6R2</accession>
    <name>A0A151P6R2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6R2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="8226" checksum="C085669046B2B04F" modified="2016-06-08" version="1">MHYCPARSTFRSLDKRLQMDLRAGKFSISLGGAYLVELHIEKHLAAHEYLMAAGNRNWLLCPVMLPPLCTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6T7</accession>
    <name>A0A151P6T7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SMC1A</name>
        <name evidence="13" type="ORF">Y1Q_0016887</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000678">
        <property type="protein sequence ID" value="KYO44782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6T7"/>
    <dbReference type="STRING" id="8496.A0A151P6T7"/>
    <dbReference type="eggNOG" id="KOG0018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030893">
        <property type="term" value="C:meiotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000001">
        <property type="entry name" value="Structural maintenance of chromosomes 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000564">
        <property type="entry name" value="Structural maintenance of chromosomes 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000001">
        <property type="entry name" value="Structural maintenance of chromosomes 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000562">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF147">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="513"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="161"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="365"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="671"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO44782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1238" mass="143458" checksum="74B3D2AC1294CC31" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8N1</accession>
    <name>A0A151P8N1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Serine/threonine-protein kinase MRCK beta</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">CDC42-binding protein kinase beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">DMPK-like beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Myotonic dystrophy kinase-related CDC42-binding kinase beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="41" type="ORF">Y1Q_0015066</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="41 42" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="41">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="27">Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="41">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P8N1"/>
    <dbReference type="eggNOG" id="KOG0612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10047816at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042641">
        <property type="term" value="C:actomyosin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20865">
        <property type="entry name" value="C1_MRCKbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01243">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000140">
        <property type="entry name" value="CDC42 binding protein kinase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000010">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001044">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001209">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031597">
        <property type="entry name" value="KELK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014930">
        <property type="entry name" value="Myotonic_dystrophy_kinase_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF34">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MRCK BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08826">
        <property type="entry name" value="DMPK_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15796">
        <property type="entry name" value="KELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19 32" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="24" id="KW-0966">Cell projection</keyword>
    <keyword evidence="22 33" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="23" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0488">Methylation</keyword>
    <keyword evidence="15 32" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="36">
        <location>
            <begin position="77"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="40">
        <location>
            <begin position="344"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="37">
        <location>
            <begin position="1026"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="35">
        <location>
            <begin position="1096"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="39">
        <location>
            <begin position="1239"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="38">
        <location>
            <begin position="1585"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="969"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="1624"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="33">
        <location>
            <begin position="434"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="33">
        <location>
            <begin position="681"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="33">
        <location>
            <begin position="781"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="33">
        <location>
            <begin position="912"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="34">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="34">
        <location>
            <begin position="1627"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="34">
        <location>
            <begin position="1665"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="34">
        <location>
            <begin position="1696"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="32">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00060291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00073267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00079250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00079498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00082349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="EMBL" id="KYO45392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1712" mass="194723" checksum="10DF7E1E7BEDF48A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8P9</accession>
    <name>A0A151P8P9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat-containing protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0015076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8P9"/>
    <dbReference type="STRING" id="8496.A0A151P8P9"/>
    <dbReference type="eggNOG" id="KOG2394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO45403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20955" checksum="6AB09B51768350B5" modified="2016-06-08" version="1">MNEIKTQFTTREGVYKLLSHSEYSRPNRVPFNSQGSNPVRVSFVNVNDQSGNGDRLCFNVGRELYFYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPDCIVTACQEGFICTWARPGKGGLLSSQNQANSPSGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9D6</accession>
    <name>A0A151P9D6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tetratricopeptide repeat protein 7B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0015170</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2). Interacts with PI4KA, interaction is direct. Interacts with EFR3 (EFR3A or EFR3B), interaction is direct. Interacts with HYCC (HYCC1 or HYCC2), interaction is direct. Association with the PI4K complex is strongly reduced by TMEM150A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9D6"/>
    <dbReference type="STRING" id="8496.A0A151P9D6"/>
    <dbReference type="KEGG" id="amj:106736834"/>
    <dbReference type="eggNOG" id="KOG4162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000030">
        <property type="entry name" value="Tetratricopeptide repeat domain 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000035">
        <property type="entry name" value="Tetratricopeptide repeat domain 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045819">
        <property type="entry name" value="TTC7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF365">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19440">
        <property type="entry name" value="TTC7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 7 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="798"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO45519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="843" mass="94355" checksum="7F15C2D839D64730" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEA0</accession>
    <name>A0A151PEA0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUMO-activating enzyme subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SAE1</name>
        <name evidence="3" type="ORF">Y1Q_0017040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000438">
        <property type="protein sequence ID" value="KYO47330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEA0"/>
    <dbReference type="STRING" id="8496.A0A151PEA0"/>
    <dbReference type="eggNOG" id="KOG2014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO47330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="214" mass="23862" checksum="AE8CE8720A829012" modified="2016-06-08" version="1">MKGLGAEVAKNLILAGVKGLTMLDHEQVRQEDTRAQFLIPVGSLGRNRAEASLERAQNLNPMVDVKADPEGVESKPEDFFTQFDAVCLTCCSRDVMVKVDQICHKNSIKFFTGDIFGYHGYMFANLGEHEFVEEKTKVAKVSPGVEDGPDAKKVKLDSSETTMVKKRVVFCQLKEALAIDWSSEKATAALKRTALDYFLLQGEQCLCLHGVWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGX1</accession>
    <name>A0A151PGX1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0000001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000254">
        <property type="protein sequence ID" value="KYO48192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGX1"/>
    <dbReference type="STRING" id="8496.A0A151PGX1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO48192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="130" mass="13471" checksum="60476CD97C41AB05" modified="2016-06-08" version="1">MRGSLPLGAQRLHVKPGTGASAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGPSSGQGCRAKASGVDPTGPLLPALPWQGQGAWACQGSWCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGX2</accession>
    <name>A0A151PGX2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000230">
        <property type="protein sequence ID" value="KYO48280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGX2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="7802" checksum="6E1D9703FA509AE5" modified="2016-06-08" version="1">MTAAGLQIKQVGGLCLEAEELKPVVEDSDRDTNNPLHSTKEEAKQGISRMTNRQELASGQVRQKPTDHAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIC3</accession>
    <name>A0A151PIC3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000178">
        <property type="protein sequence ID" value="KYO48861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIC3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10729" checksum="BE03B268C3745CB7" modified="2016-06-08" version="1">MIPLHWQVGYNLDLLANPKIMCPIMHMRHGKKCDGPDYLPVIHANIWKDSRSLFDASKIPDASFCRGVAAFQDAFLLSVPFWSESPDCDTLQAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIY3</accession>
    <name>A0A151PIY3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000170">
        <property type="protein sequence ID" value="KYO48942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIY3"/>
    <dbReference type="STRING" id="8496.A0A151PIY3"/>
    <dbReference type="eggNOG" id="ENOG502RD3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.960:FF:000003">
        <property type="entry name" value="MUC16 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028850">
        <property type="entry name" value="MUC16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14672">
        <property type="entry name" value="MUCIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14672:SF1">
        <property type="entry name" value="MUCIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="132" mass="14786" checksum="8DC06798313F189C" modified="2016-06-08" version="1">MIEQFTVNFTITNLQYSTALGTPGSNTFNATEKNLAHLLNPIFRESSIGPAYLECKVMAYRPVRDRGNTGVDAACTYRNDSTRPPFDRVRVYHEVHNRTNGVTQLGPYTLDEGSLYINGYNEAPALPSEYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZZ4</accession>
    <name>A0A151LZZ4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein Hox-D10 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HOXD10</name>
        <name evidence="11" type="ORF">Y1Q_0011480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZZ4"/>
    <dbReference type="STRING" id="8496.A0A151LZZ4"/>
    <dbReference type="eggNOG" id="KOG0487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF5">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="289"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="291"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO17806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="378" mass="43075" checksum="E077DFEEC9B5932B" modified="2016-06-08" version="1">MSTGDFGGLAEHNPAKGNLGVLKSWAFVRSEETTYFRAKRKAPDIYPCTKVWGGLLIASMYMPPSTDIGTYGMQTCGLLPSLAKREVNHQNMGMNVHPYIPQVDSWTDPNRSCRIEQPVTQQVPTCSFTTNIKEESNCCMYSDKRTKLISSEVPSYQRLVSESCPIENPEVPVPGYFRLSQTYATGKTQEYNNSPETSSTVMLQLNPRGSSKPQISSQLQMEKKMNENPNNQDNSAKVSQVESPEPKSTLQEERSCLAEGSVSSPEVQEKESKEEIKSDTPTSNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEITSENNKSLNKQEFQPLPYTSQFQYIHLQSVWGTELCCRTWQPQFSGLIYSQYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M431</accession>
    <name>A0A151M431_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006640">
        <property type="protein sequence ID" value="KYO19275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M431"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43427" checksum="F30E8E113F0F609B" modified="2016-06-08" version="1">MTCLKDGARVEYWSKDGMLETVAAFYWELYAERPVNLEAMQECLWGPTQTLGEADQQQLEEKWTLEEVERTLWTFKNGRTLGSDGLPNEFYEIFWDLVSPDLLELFQEQLQEGHVGAGIDWGLVTEMLYMDMSSEGKVIGFLSARIMVESGVHQGYPLSLILFICTVEPLAQCIRQNPRMNRVQIPDGSRKEIRDLAYMDDLNILCQNKWSVERFLWHTQVYEAATGAKFKVSNSICLATGELRDLEFLGVSVPCEGAKILGMEFDPEVSSQKAWKKTEAKMFCKTPPETMEVFTLTNGTLWTLDHSWFYKILNNFHNMYGLQNEGPAMMANHRKIQEVVRTRDVLSPVDLLLGNGCQAVWERIFYKDLQKDHRDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M462</accession>
    <name>A0A151M462_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 250-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0004776</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006634">
        <property type="protein sequence ID" value="KYO19286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M462"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151M462"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001789">
        <property type="entry name" value="zinc finger protein 467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000180">
        <property type="entry name" value="Zinc finger protein 689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000290">
        <property type="entry name" value="Zinc finger protein 697 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO19286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="266" mass="29225" checksum="1B7B5703AE5DE2E7" modified="2016-06-08" version="1">MAAAPAPAQDPVSFEDVAVYFTEGEWVLLGAAQRALYWEVMRENYEAVALLGFPIFKPVMIAQLEQGEEPWVLSPPGADHQVEMVPRDTCAAPLGTQNPLVPATENGDESPREPGWPPKGPAERPHACPDCGKAFRLRSQLATHQRVHTGERPFSCETCGRCFSQSSNLAKHLGTHRGHKPHACPDCGKGFSQRSSLLTHQRLHTGETPYHCPDCGRGFRVGSQLATHQRLHAGRMPYRCGVCGKSFSWSRHLAAHQQLHTTVGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4N0</accession>
    <name>A0A151M4N0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006597">
        <property type="protein sequence ID" value="KYO19472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4N0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="8989" checksum="34626CB2E0E900DF" modified="2016-06-08" version="1">MVYRIPASPVTRVVLPFSISDVGCSHHGTQPDDITALCFVAPALQLEEGITLFLHSACPSGVTISSTSRLSSDTELFVTIFSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4R3</accession>
    <name>A0A151M4R3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="18">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">USP21</name>
        <name evidence="21" type="ORF">Y1Q_0014853</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with BEND3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the peptidase C19 family. USP21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03006595">
        <property type="protein sequence ID" value="KYO19496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4R3"/>
    <dbReference type="STRING" id="8496.A0A151M4R3"/>
    <dbReference type="eggNOG" id="KOG1868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000058">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 18" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="USP" evidence="20">
        <location>
            <begin position="110"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO19496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="458" mass="51933" checksum="128DF3C6B5F4DFED" modified="2016-06-08" version="1">MLSRLELRDHSPSCSHKLGLGVVALKRSSSLRRVNVSPGLDGRPMATLLSVRPEGCLRTHTTDPQTSEYARPQDHSMSGSPLQGKAPTAGRPEEKVFATHHTLLLGSGHIGLRNLGNTCFMNAVLQCLSSTKPLRDYCLRKEFHQEQPSASRAQQELTEAFADVITALWHPDSTEAVNPGRFKAIFQKYVPSFTGYSQQDAQEFLKFFMDRLHVEINRKGRRTPSILADAKRTSVLEDLDALSDDERANQMWKRYLEKEDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLHDCFSLFTKEEELDSENAPVCDKCRQRTRSTKKLTIQRFPRILVLHLNRFSTTRYSIKKCSVFVEFPLQQLNLKEFASEKAGSPVYSLYALCNHSGSVHYGHYTAFCRDQSGWRVYNDSRVTPISENQVQSSEGYVLFYELDDPHWKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5D8</accession>
    <name>A0A151M5D8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UBE2L3</name>
        <name evidence="8" type="ORF">Y1Q_0016128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006569">
        <property type="protein sequence ID" value="KYO19737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5D8"/>
    <dbReference type="STRING" id="8496.A0A151M5D8"/>
    <dbReference type="eggNOG" id="KOG0422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23801">
        <property type="entry name" value="UBCc_UBE2L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000011">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO19737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="159" mass="18413" checksum="114E25CC125657C0" modified="2016-06-08" version="1">MYLTLMELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYDSPPVWQVDILANCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M671</accession>
    <name>A0A151M671_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0004714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006440">
        <property type="protein sequence ID" value="KYO20025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M671"/>
    <dbReference type="STRING" id="8496.A0A151M671"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21188">
        <property type="entry name" value="CH_PLEC-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000029">
        <property type="entry name" value="plectin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO20025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="19170" checksum="42D71F5E4FD09D40" modified="2016-06-08" version="1">MSRHRLPSSEVPGLQVGQRTGSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQRHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHKLQNVQIALDYLKHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQVGVGAMYCGQRRGRRGKDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7E2</accession>
    <name>A0A151M7E2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0006545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006414">
        <property type="protein sequence ID" value="KYO20424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7E2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="137" mass="15676" checksum="2467EA84EE30FEFF" modified="2016-06-08" version="1">MQNLLYLVYYTHFYVKGVKLEFSVSMEICNRMEPEDTTDTHLSGSRIPIGGIVCLTQLYHQKTVGEDGKEVAKTIWQMCHWHRLFEDIASPEEESGDVEEEIEASEEESGSSDNNNENSDSDDGEKDSERIMTFTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7M9</accession>
    <name>A0A151M7M9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Histone-lysine N-methyltransferase SETD1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SETD1A</name>
        <name evidence="18" type="ORF">Y1Q_0012148</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006359">
        <property type="protein sequence ID" value="KYO20533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7M9"/>
    <dbReference type="STRING" id="8496.A0A151M7M9"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12548">
        <property type="entry name" value="RRM_Set1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19169">
        <property type="entry name" value="SET_SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000010">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000178">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034467">
        <property type="entry name" value="Set1A_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037841">
        <property type="entry name" value="SET_SETD1A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="81"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="924"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="1047"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="196"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="643"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="219"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO20533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118599" checksum="07ACDEE892011196" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7N9</accession>
    <name>A0A151M7N9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7N9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="111" mass="12225" checksum="E4F3D16D29B77642" modified="2016-06-08" version="1">MKVAILESGHFGRAVIRAEHVEISQWGVTLHGGVSVPGIFQRFPSWIAVALPDPADHILSPDPNGHNFSLSCFLAVTEEDLDNTFRKVQNESSNSMNAVGKMKSFIQECLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8E6</accession>
    <name>A0A151M8E6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein prune homolog 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">BNIP2 motif-containing molecule at the C-terminal region 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PRUNE2</name>
        <name evidence="11" type="ORF">Y1Q_0012626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase class C family. Prune subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M8E6"/>
    <dbReference type="eggNOG" id="KOG4129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000001">
        <property type="entry name" value="BCL2/adenovirus E1B protein-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.20:FF:000002">
        <property type="entry name" value="Prune homolog 2 with BCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1640.10:FF:000003">
        <property type="entry name" value="Prune homolog 2 with BCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022181">
        <property type="entry name" value="Bcl2-/adenovirus-E1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF49">
        <property type="entry name" value="DHHA2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12496">
        <property type="entry name" value="BNIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="10">
        <location>
            <begin position="2284"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1342"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1656"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1703"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1857"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2060"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2133"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1130"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1151"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1188"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1717"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1773"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1793"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1879"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2060"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2073"/>
            <end position="2090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO20761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2446" mass="274092" checksum="BB2F66ED0E26F0AC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8Y7</accession>
    <name>A0A151M8Y7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO20974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8Y7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7632" checksum="4317503C6BEF928B" modified="2016-06-08" version="1">MSFQNDSHHHAKLTVNLGLASAGTVMLAVWCTSHLRRSSSKGLRFHLIIQENDSTCSCSHGDRKRMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M995</accession>
    <name>A0A151M995_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ammonium transporter Rh type C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RHCG</name>
        <name evidence="13" type="ORF">Y1Q_0001387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M995"/>
    <dbReference type="STRING" id="8496.A0A151M995"/>
    <dbReference type="eggNOG" id="KOG3796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000001">
        <property type="entry name" value="Ammonium transporter Rh type C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF30">
        <property type="entry name" value="AMMONIUM TRANSPORTER RH TYPE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="12">
        <location>
            <begin position="36"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO21083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="380" mass="41707" checksum="7DB7002DDF04EC63" modified="2016-06-08" version="1">MIILFGVFVRFTPEASARWEEEEKKQNNITSDIENDFYYRYPSFQDVHVMIFIGFGFLMTFLQRYGFGAVGFNFLLASFGIQWAILMQGWFHSFKDGKILIGVENLINADFCVGSVCVAFGAILGKSSPVQLLIMTLFQVTLFSVNEYILLNLLHVIDAGGSMTIHTFGAYFGLTVTRILYRPNLEQSKDKQGSVYHSDIFAMIGTIFLWMYWPSFNSAVSNHGDAQHRAAINTYCSLAACVLTTVAFSSMLEKKGKLDMVHIQNATLAGGVAVGTSAEMMLPPYGSLIVGFICGIVSTVGYVYLTPFLESRLHIQDTCGIHNLHGMPGIIGGIVGAITAAAATKRVYGSEGLVKTFDFTGDYANRTPMPLLGGPLWGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAX3</accession>
    <name>A0A151MAX3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0003389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006286">
        <property type="protein sequence ID" value="KYO21651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MAX3"/>
    <dbReference type="STRING" id="8496.A0A151MAX3"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151MAX3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000522">
        <property type="entry name" value="Leucine rich repeat neuronal 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000887">
        <property type="entry name" value="leucine-rich repeat neuronal protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000301">
        <property type="entry name" value="leucine-rich repeat neuronal protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF211">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584948" description="Ig-like domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="421"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO21651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="706" mass="80080" checksum="B1F68340F03459AC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBZ1</accession>
    <name>A0A151MBZ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBZ1"/>
    <dbReference type="eggNOG" id="KOG3736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584974" evidence="1">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8113" checksum="FCA03779035293BB" modified="2016-06-08" version="1">MTNIICLLYVGWVTNYIASVYVKVQEPMAEKKLEDDKGDTLRIIERLDHLENVIKQHIQANAKPGSLLMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCJ7</accession>
    <name>A0A151MCJ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Perilipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PLIN4</name>
        <name evidence="6" type="ORF">Y1Q_0000312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006238">
        <property type="protein sequence ID" value="KYO22231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCJ7"/>
    <dbReference type="STRING" id="8496.A0A151MCJ7"/>
    <dbReference type="eggNOG" id="ENOG502R7TG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.170">
        <property type="entry name" value="Perilipin, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF11">
        <property type="entry name" value="PERILIPIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO22231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="503" mass="54865" checksum="136A76EFF6367205" modified="2016-06-08" version="1">MFLAGVEQEALCGLELLGGMWLACSFLLASPHSGVTMSDESTADHIPAQSEEPEQPQNVVSRVANLPLVSSTYDMVSTAYTSTKENHPYLKSVCDVAEKGVKTLTSVAVSGAQPLLTKLEPQIATANQYACKGLDKLEEKLPILQQPTEKVVADTKELVSSTVTGARDTVSSTVNGAKDAVSSRVTGVVDLAKGAVQGSVEMTKSVVNSSVNTVLGSRVAQMVVTGVDAVLGKSEELVDHYLPMTDQELAKLATSVEGFEMASVEQQKRQQSYFVRLGSLSSKLRHRAYQHSLGKLRCARQSTQEGLAQLHHTIELIEHVKQGVDQRLHNGQEKLHQMWLEWSRRQPGGSEQYDAAHPEVESRTLVMFRGITQQLQASCLGLMANVQGLPASIQDKVQQMRHHMEELHTSFSAAHSFQDLSSTVLTQSRERVTKARESLDELLDYVAQNAPLPWLVGPFAPVLVEHPENLAIGMEKKEDQATCPGQSREEKPAQQASEAKKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCN8</accession>
    <name>A0A151MCN8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acrosin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acrosin-binding protein, 60 kDa form</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Proacrosin-binding protein sp32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ACRBP</name>
        <name evidence="11" type="ORF">Y1Q_0002898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014459379.2">
        <property type="nucleotide sequence ID" value="XM_014603893.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCN8"/>
    <dbReference type="STRING" id="8496.A0A151MCN8"/>
    <dbReference type="GeneID" id="102573427"/>
    <dbReference type="KEGG" id="amj:102573427"/>
    <dbReference type="CTD" id="84519"/>
    <dbReference type="eggNOG" id="ENOG502R6TS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9009946at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009865">
        <property type="entry name" value="Proacrosin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21362">
        <property type="entry name" value="ACROSIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21362:SF1">
        <property type="entry name" value="ACROSIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07222">
        <property type="entry name" value="PBP_sp32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584970" description="Acrosin-binding protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO22296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="317" mass="35432" checksum="DF09E24707E5AD97" modified="2016-06-08" version="1">MMGLHFLSCGLLVAFLHSLALPLCGKSPPAPGTPLSDSEYQVFFSALLSSQKANMFCQIRRTQGCYDPNIIWLDQHENHGWIPEGSVCTNLPEASLFQTFCEFAQYRCTTRKFYIKRILCPDLPPPKKSPAQAERPHTMGSWAKSDSLALTSPPKKPDSRHLKEDRRQHTDIRLYPHIDAILKYAYAVSGQEPMPKGFLHVMPVRQRTQERLDVPGHLQGQAVTALSETSLRVKLSTKIERGTKQHIDYVIEQLINLAFSLEGSLDVKTTPVPVGTELDQKGSNSGAQEEVPVASFTGRENPEDLIPVQSDISISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCW1</accession>
    <name>A0A151MCW1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ferroxidase</fullName>
            <ecNumber evidence="5">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">F5</name>
        <name evidence="23" type="ORF">Y1Q_0002960</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006271882.1">
        <property type="nucleotide sequence ID" value="XM_006271820.4"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MCW1"/>
    <dbReference type="GeneID" id="102576014"/>
    <dbReference type="KEGG" id="amj:102576014"/>
    <dbReference type="CTD" id="2153"/>
    <dbReference type="eggNOG" id="ENOG502QSUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14450">
        <property type="entry name" value="CuRO_3_FV_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000028">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000050">
        <property type="entry name" value="coagulation factor V isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000002">
        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000011">
        <property type="entry name" value="Coagulation factor VIII (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000002">
        <property type="entry name" value="Hephaestin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024715">
        <property type="entry name" value="Factor_5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF10">
        <property type="entry name" value="COAGULATION FACTOR V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000354">
        <property type="entry name" value="Factors_V_VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="17 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 21" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584977" description="ferroxidase" evidence="21">
        <location>
            <begin position="29"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="22">
        <location>
            <begin position="1633"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="22">
        <location>
            <begin position="1788"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1128"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="249"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="604"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1454"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1633"/>
            <end position="1783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000354-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO22368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1945" mass="221389" checksum="5EC5F9A367527558" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDH3</accession>
    <name>A0A151MDH3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core shell protein Gag P30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0003102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDH3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="entry name" value="Human Immunodeficiency Virus Type 1 Capsid Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050462">
        <property type="entry name" value="Retroviral_Gag-Pol_poly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33166">
        <property type="entry name" value="GAG_P30 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="Retrovirus capsid protein, N-terminal core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core shell protein Gag P30" evidence="2">
        <location>
            <begin position="218"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO22568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="433" mass="48678" checksum="3FA0D8CAD246E15D" modified="2016-06-08" version="1">MDAWYLWDDEAEKRKLRSQVASHKANTEKLTEQLSQMKASVPTPSASAPPSFSPFYPQIPRRPEPPSDLLDSWVPPLSPPPPPPGPNQGAAAETPETPLALPLAVTPENPIILPDPTDPNGVVVIHLTPEQNDTYHIDRVEPGDTGDDLVMVYSPRANPEAIRTVGLSPAHITQRRRQGLVPFRQLPRNPVRQLPLREYPNPTGGQPLQVHVPWTPGDLLNWQDTFPKMREDPLGFKRKLQTVCSIYKPTWGDINQLLDTILNPDQRQQLTSAATWPRQEPPDDATLQDAITNLLGAVNTICPFKPDWGKAPEFQPTDSWECQWTRDTKVKIQRIKGFIGIVNRMNCAVKLRMEGRKRERVVCLHKRDLFKSDVMTLSTGQFSHFSMEYSTSYVPSPSPSSMRGTTSPPPELANWVRKEESVPPGRTLHLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDY4</accession>
    <name>A0A151MDY4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="44">Amyloid-beta A4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="50" type="ORF">Y1Q_0003230</name>
    </gene>
    <organism evidence="50 51">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="50 51" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="50">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="44">Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 44">Cell membrane</location>
            <topology evidence="3 44">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell projection</location>
            <location evidence="10">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <location evidence="8">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 43 44">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="43">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="50">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDY4"/>
    <dbReference type="STRING" id="8496.A0A151MDY4"/>
    <dbReference type="eggNOG" id="KOG3540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005798">
        <property type="term" value="C:Golgi-associated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030546">
        <property type="term" value="F:signaling receptor activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22607">
        <property type="entry name" value="Kunitz_ABPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.140:FF:000001">
        <property type="entry name" value="Amyloid beta (A4) protein b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.570.10:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.230.10:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.770:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.770">
        <property type="entry name" value="Amyloid precursor protein, E2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.230.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, amyloid-beta peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.140">
        <property type="entry name" value="Amyloidogenic glycoprotein, copper-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.570.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036669">
        <property type="entry name" value="Amyloid_Cu-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008155">
        <property type="entry name" value="Amyloid_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013803">
        <property type="entry name" value="Amyloid_glyco_Abeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037071">
        <property type="entry name" value="Amyloid_glyco_Abeta_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011178">
        <property type="entry name" value="Amyloid_glyco_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024329">
        <property type="entry name" value="Amyloid_glyco_E2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008154">
        <property type="entry name" value="Amyloid_glyco_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015849">
        <property type="entry name" value="Amyloid_glyco_heparin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036454">
        <property type="entry name" value="Amyloid_glyco_heparin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019745">
        <property type="entry name" value="Amyloid_glyco_intracell_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019543">
        <property type="entry name" value="APP_amyloid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019744">
        <property type="entry name" value="APP_CUBD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036176">
        <property type="entry name" value="E2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103">
        <property type="entry name" value="ALZHEIMER'S DISEASE BETA-AMYLOID RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103:SF7">
        <property type="entry name" value="AMYLOID-BETA PRECURSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10515">
        <property type="entry name" value="APP_amyloid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12924">
        <property type="entry name" value="APP_Cu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12925">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02177">
        <property type="entry name" value="APP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03494">
        <property type="entry name" value="Beta-APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00203">
        <property type="entry name" value="AMYLOIDA4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00204">
        <property type="entry name" value="BETAAMYLOID"/>
    </dbReference>
    <dbReference type="SMART" id="SM00006">
        <property type="entry name" value="A4_EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56491">
        <property type="entry name" value="A heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89811">
        <property type="entry name" value="Amyloid beta a4 protein copper binding domain (domain 2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109843">
        <property type="entry name" value="CAPPD, an extracellular domain of amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00319">
        <property type="entry name" value="APP_CUBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51869">
        <property type="entry name" value="APP_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51870">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00320">
        <property type="entry name" value="APP_INTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="35 44" id="KW-0034">Amyloid</keyword>
    <keyword evidence="22" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="29" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12 44" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="41" id="KW-0966">Cell projection</keyword>
    <keyword evidence="38" id="KW-0168">Coated pit</keyword>
    <keyword evidence="45" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="33" id="KW-0186">Copper</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="42" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="37 43" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="26" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="25" id="KW-0967">Endosome</keyword>
    <keyword evidence="39" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="34" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="19" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="32" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="36 44" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="40" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="51" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0964">Secreted</keyword>
    <keyword evidence="30" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="24" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0765">Sulfation</keyword>
    <keyword evidence="21 44" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="31 44" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="28" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="27" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="44">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="E1" evidence="48">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="47">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="E2" evidence="49">
        <location>
            <begin position="347"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="GFLD subdomain" evidence="43">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="CuBD subdomain" evidence="43">
        <location>
            <begin position="123"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="46">
        <location>
            <begin position="185"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="45">
        <location>
            <begin position="372"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="46">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="46">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="46">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="43">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="43">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="43">
        <location>
            <begin position="125"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="43">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="43">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="47">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="49">
        <source>
            <dbReference type="PROSITE" id="PS51870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="50">
        <source>
            <dbReference type="EMBL" id="KYO22727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="51">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="743" mass="83967" checksum="93BC10096023E572" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFC6</accession>
    <name>A0A151MFC6_ALLMI</name>
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            <fullName evidence="2">Tetratricopeptide repeat protein 16</fullName>
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        <name evidence="2" type="primary">TTC16</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
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                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153:SF1">
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    </dbReference>
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    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="636" mass="71182" checksum="D94A49E1705AE5CE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGA1</accession>
    <name>A0A151MGA1_ALLMI</name>
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        </submittedName>
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        <name evidence="2" type="ORF">Y1Q_0015347</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
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                <person name="Khan S.Y."/>
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                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
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                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
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                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="amj:102567740"/>
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    </dbReference>
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            <end position="28"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO23562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="187" mass="20808" checksum="A54B9975304BB089" modified="2016-06-08" version="1">MKSLYEVTGWVLISFGITSIFSGILAFFPAFSYKPWFVGWSVRIACPIWNGAVALIAGVLVLLADREHTQRSLWEASFSFGVLSITGSSIQFAVAIAATLLGPYCYYSFAGIAGTNYLGYAVLIPFPYTKFTAICKDPLSYEWYHLVLQILDLCSSFAMFCASLAFVIKLTVRLLQFGHLNGQRHVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGF1</accession>
    <name>A0A151MGF1_ALLMI</name>
    <protein>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MORN5</name>
        <name evidence="7" type="ORF">Y1Q_0005815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
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                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
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                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
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                <person name="de Koning A.J."/>
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                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267308.2">
        <property type="nucleotide sequence ID" value="XM_006267246.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGF1"/>
    <dbReference type="STRING" id="8496.A0A151MGF1"/>
    <dbReference type="GeneID" id="102564281"/>
    <dbReference type="KEGG" id="amj:102564281"/>
    <dbReference type="CTD" id="254956"/>
    <dbReference type="eggNOG" id="KOG0231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300500at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042814">
        <property type="entry name" value="Morn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO23460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="172" mass="19686" checksum="603BF11420F9D17C" modified="2016-06-08" version="1">MEVTGSNYIGGRARGRLEGSGCYMLPTMSQYKGEMKDGMFHGKGTLHFPNGGKYDGVWDRGIAKEGKYTFADGLEFKEKNWHYCDSYDRRFYTEICSGLKPAGISQLTNLDPPRSIPEGCYDCGDGFYNPNTRVITDYKLRFLRNADDDEHEWIVRTCRKGWDEIIGHKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHD9</accession>
    <name>A0A151MHD9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MAD2L1-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MAD2L1BP</name>
        <name evidence="1" type="ORF">Y1Q_0015903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHD9"/>
    <dbReference type="STRING" id="8496.A0A151MHD9"/>
    <dbReference type="eggNOG" id="ENOG502QTUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009511">
        <property type="entry name" value="MAD1/Cdc20-bound-Mad2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681:SF1">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06581">
        <property type="entry name" value="p31comet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="178" mass="19950" checksum="38C9F8ACDF750722" modified="2016-06-08" version="1">MKVEDVIKKLHSTDLGSKKCQQALVDLEGLFQHLEAMFHLTLVPRILILLGGNAMNPKELYEINLEGICVGNAEESLQTPSCVRKLFHSLFLADVFSELQALPVMGTTVMVQGHRDCGIDWFRPKLNYKVPTRGRKLTVNLSCSGDSCTSPSTHMGMTSPWEDYIWFQAPVTVKGFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHH5</accession>
    <name>A0A151MHH5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Histone-lysine N-methyltransferase SETDB2</fullName>
            <ecNumber evidence="15">2.1.1.366</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">SET domain bifurcated 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SETDB2</name>
        <name evidence="23" type="ORF">Y1Q_0004564</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60288"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.366"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.366" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO23961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHH5"/>
    <dbReference type="STRING" id="8496.A0A151MHH5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140947">
        <property type="term" value="F:histone H3K9me2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070828">
        <property type="term" value="P:heterochromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01395">
        <property type="entry name" value="HMT_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10523">
        <property type="entry name" value="SET_SETDB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000029">
        <property type="entry name" value="Histone-lysine N-methyltransferase SETDB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047232">
        <property type="entry name" value="SETDB1/2-like_MBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051516">
        <property type="entry name" value="SETDB_methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46024:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETDB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
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    </dbReference>
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        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="383"/>
            <end position="706"/>
        </location>
    </feature>
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        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
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        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="421"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040299"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO23961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="731" mass="82800" checksum="5435727DDB5CEE6E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7075" checksum="F8AE5357BD7FB02B" modified="2016-06-08" version="1">MNGVDGSPAEEREAAFQSAPIIYLGCRLKYIATSVLAPSASPVLTATASATFQSKFSYAALLRFETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKA1</accession>
    <name>A0A151MKA1_ALLMI</name>
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    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
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                <person name="Densmore L.D."/>
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                <person name="Edwards S.V."/>
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                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
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                <person name="Pourmand N."/>
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                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKA1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="123" mass="13959" checksum="D9F21C1247CD1224" modified="2016-06-08" version="1">MVDILHHDDERCPTFLGFFLKFSWNTPKQVYLGQPLTANGKAKGIRLFSSFTIKVVFTSTGNSEMHLQPLFGENSCRLHFPRQWITAVTCHIWPSESHAAGFSLFLNFLAANTPTRLQVPVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ML51</accession>
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        <submittedName>
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    <organism evidence="1 2">
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        <name type="common">American alligator</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005879">
        <property type="protein sequence ID" value="KYO25258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ML51"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="113" mass="12666" checksum="B5E7CB29039A5FF5" modified="2016-06-08" version="1">MKVLECHSHLLTLFSSSEMIPLSDSLMHHLGQIELAETASISLISKKSRLGELPNHQALPARCYIQTPLQGCPLMVTALTRASSGERTTNWDFLCPSSQQEIDEYKTKLNPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLF2</accession>
    <name>A0A151MLF2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005819">
        <property type="protein sequence ID" value="KYO25355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLF2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="110" mass="11226" checksum="B25F9EE30962CF75" modified="2016-06-08" version="1">MLPGGSARSCCFGEGPFSPVCGSRPLRDTSGSPGQGPSPSLRTPRTEGGRNCARALVEQAESTTSMVARSRGSVPLQPLPMSRNKASCTDIATIPTSPLGKCPGCSLTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MM90</accession>
    <name>A0A151MM90_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Maestro-like HEAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0023949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005753">
        <property type="protein sequence ID" value="KYO25510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MM90"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF40">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="2">
        <location>
            <begin position="117"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO25510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="345" mass="38300" checksum="EE4F99B9E51DFEDD" modified="2016-06-08" version="1">MGPGRGILAKDLMETISVEGDQKHVLAYSIDAIRCLSDPKLSLEPALESRLLRTAVDKSFLAIRRETHRNQVMQRLYEEYLEGLLCCVLSSAPSLGKLYSIWEHFTSWIEAPDAQHRALGMKIMTGAIAFAVQLLPQFEGSPDIPEVGDMAARLGLTINDPEETITCKARACMYLLAQILLHQRGQDMRGAEELRCKRQNEQSQVQKYRDLARVGEGLRNILLEEQRRAFLQRALHAVHSRPIHISQAGLVFLYAILGEASRLMEHKEKEIPIRVVNKLFIITCLKELPQDLQGHSLLVTSCSALASLQPPTLAPAATPADHLNPEGTSMSEDDLPNLTGSPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMF0</accession>
    <name>A0A151MMF0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SERTA domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SERTAD1</name>
        <name evidence="3" type="ORF">Y1Q_0016902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005730">
        <property type="protein sequence ID" value="KYO25570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006257966.1">
        <property type="nucleotide sequence ID" value="XM_006257904.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMF0"/>
    <dbReference type="STRING" id="8496.A0A151MMF0"/>
    <dbReference type="GeneID" id="102576420"/>
    <dbReference type="KEGG" id="amj:102576420"/>
    <dbReference type="CTD" id="29950"/>
    <dbReference type="eggNOG" id="ENOG502S52T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6083860at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MMF0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052262">
        <property type="entry name" value="E2F-SERTA_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009263">
        <property type="entry name" value="SERTA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277">
        <property type="entry name" value="CELL DIVISION CYCLE ASSOCIATED PROTEIN 4/SERTA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277:SF12">
        <property type="entry name" value="SERTA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06031">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51053">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERTA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO25570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="295" mass="29468" checksum="63412EEF9D45FDCF" modified="2016-06-08" version="1">MLNKGVKRKRGTAESAGPDAPASPAAPATSLFSLSVVKLHRSLRHVEPDLRPLVLVTNALRRLQDQMQTEAAAPEPPGTVLRCPAAPPDGSGALPDCPTCPLDGSGAPLDSSGALPDCPTGPLDSSGAPLDSSGTLPDCPMGPLEGSGAPLDSSGALPDWPTGPLDGSSAPLDSSGILLGTGPAMLLPSLDVSLGSSVSGLLGDLEPAGSLVPALWGAECGARALLAPLPDEGLEGVFEDIDTSMYDGELWAPAGLKALAPAPGEDEAAPGPEDGGLDINDLDLLMDVLVGPRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMT2</accession>
    <name>A0A151MMT2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0023637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMT2"/>
    <dbReference type="STRING" id="8496.A0A151MMT2"/>
    <dbReference type="eggNOG" id="KOG3898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF161">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO25832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="12632" checksum="7641FC6C9412CF5B" modified="2016-06-08" version="1">MHDLNQALDGLREVMPYSQGPAVRKLSKIATLLLARNYILTLSSSLQEMRRLLGELRAGPPACSLGYPAFRAAPAPHEPPGPAYRHYSGLACPCSLCQALPPQLPRTAAAHACLGTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN50</accession>
    <name>A0A151MN50_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large ribosomal subunit protein uL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">60S ribosomal protein L7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RPL7</name>
        <name evidence="14" type="ORF">Y1Q_0003749</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN50"/>
    <dbReference type="STRING" id="8496.A0A151MN50"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 14" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="13">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="12">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO25968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="223" mass="25846" checksum="F0E746D86B40F84B" modified="2016-06-08" version="1">MAGKEAKKVPSVPESLLKKRKAFADIKAKRLKRLLVQKKLRKAQRELIYGRAQAYHKEYRKMYRQEIRMARMARKAGNYYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVHELIYKRGYGKINKQRVALTDNSLIEKCLGKFGIICMEDVIHEIYTVGKNFKATDKENELKCRCPAADFPAMVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRM6</accession>
    <name>A0A151MRM6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ANKRD33</name>
        <name evidence="5" type="ORF">Y1Q_0011155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005250">
        <property type="protein sequence ID" value="KYO27194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRM6"/>
    <dbReference type="STRING" id="8496.A0A151MRM6"/>
    <dbReference type="eggNOG" id="ENOG502QRWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF29">
        <property type="entry name" value="PHOTORECEPTOR ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO27194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="437" mass="47999" checksum="31415EF80DDBBE59" modified="2016-06-08" version="1">MTDGGGGEHTANPAFDPELHYEEEEEEEGEELGDTLKASETSSIFSDDSVYPCYTPVPCSGDQGELTLHQCCARNCAALLRDKLESGVTRQEAVQLDANGRNGLMVACYAGFLDIVVLLSGCPYVDINHQDNDGNTALMIAAQAGHDMIVNYLLNYYPGLEVDKRDARGLTALMKAAIQGCNNCVTALVLAGADLNAVDPVKGKTAREWAVFTGRFETIVQIRRLLQRPRAEQFSSEYLPEWPALPELVAKALATKTRGERMQEKIRSSFSFRFPHDPEVDGVMDHMVKITTSLASPFVSTACQTICPLSPPEVGKRRLAVPEILRAQVPNAEPPAEAKTCSGAEELPGCSQPPALASSQPRGSMPSFLPLRLLRRSSIFPEDHVPRIKLTKPPAPPASAEEQPEESQDRNTLRLPKWRYKELREKRRAAKELEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MS29</accession>
    <name>A0A151MS29_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0021245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03005226">
        <property type="protein sequence ID" value="KYO27325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MS29"/>
    <dbReference type="STRING" id="8496.A0A151MS29"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="90"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO27325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="239" mass="27418" checksum="5D9C6734D776F1F6" modified="2016-06-08" version="1">MELASQLSEDQREQAAELIRKLEDVFQETPGEARGVVHQIKTPPGQVIRESWRRIPQRLQSQIKTEIEMMLEKGIICRSHSDWRSPIVVVPNPDGKIHLCIDFQKVNAVAKFDAYPMPRVDELVENIGQARYISTLDLTKGYWQVLIAPEDQEKTAFATPWGLFQFRHMPFGLHGAAAMFQRLMDRVLAPHMGEEGALKSSLQYSSFYSEIYLDHTIQEVSVPPKIILQNNFKLKGQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTS1</accession>
    <name>A0A151MTS1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low-density lipoprotein receptor class A domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LDLRAD2</name>
        <name evidence="5" type="ORF">Y1Q_0023297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005052">
        <property type="protein sequence ID" value="KYO27916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019352465.1">
        <property type="nucleotide sequence ID" value="XM_019496920.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTS1"/>
    <dbReference type="GeneID" id="102559366"/>
    <dbReference type="KEGG" id="amj:102559366"/>
    <dbReference type="CTD" id="401944"/>
    <dbReference type="eggNOG" id="ENOG502R5YQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6514358at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF67">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585453" evidence="4">
        <location>
            <begin position="26"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO27916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="362" mass="38350" checksum="CA0A2F5C73A4698E" modified="2016-06-08" version="1">MAKSSPRHCLRLLSGWLVLFSCAVAEVSSIETVSLVDFCGQTLQDNGMIVTSHRDSRRYYFVAVGTDCHLVMQAAAPRDKVQFQFRFFLVYSLLRLPLPGGPAPSTTATLPPLGSPRPPQTPSGGDREPPDPCHAGSYVQFYDGRGRAAEPLGRPLCGKSIPRPVLSTGNFLTLRLVTRGQQPRVDFVGDFTSFRLGFNMSGCGQEPYFPCRNGKCIPQSLVCDSAGVDNCGDGSDQAARPPASCKGPVPTAAPLQTARALAASSASSCGRPEKSQSPPQDTNLQEDAAEGGRLALPALSALLGAAAGAGLLLWCCCSPGWLVWRLGACRFLPGCNSACAACQLCPRSCTRRGKVAPRHLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV57</accession>
    <name>A0A151MV57_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kunitz-type protease inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SPINT1</name>
        <name evidence="13" type="ORF">Y1Q_0015968</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV57"/>
    <dbReference type="STRING" id="8496.A0A151MV57"/>
    <dbReference type="eggNOG" id="KOG4295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22623">
        <property type="entry name" value="Kunitz_HAI1_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22624">
        <property type="entry name" value="Kunitz_HAI1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000061">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000006">
        <property type="entry name" value="Serine peptidase inhibitor, Kunitz type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000008">
        <property type="entry name" value="Serine peptidase inhibitor, Kunitz type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46750">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46750:SF1">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07502">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="12">
        <location>
            <begin position="210"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="12">
        <location>
            <begin position="335"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO28364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="473" mass="52558" checksum="4E1DC79DCD9DDD0A" modified="2016-06-08" version="1">MQGKLAQAPREGDKVPDTCPPRPGGVESSSWARRRLLAGTITAGSASCPSCSPVEQSPDGGEDGVRACFLLNCLYEQAFVCKFARKAGFLNYVKRDVYDAYVSMREKGEGDDLPPKARAGMDMKVQPGEAVVLRGAESSDDHGIVSYDWKHLSGDSSVVLEKKGDDQVEVSNLQKGIYVFQLTVTDTVNQQDTTNITITVLNAEQTEDHCLTPSKVGRCRGSFPRWFYNPESQQCEKFIFGGCKPNKNNYLREEECNLACKDVRGPVGRRQQPVCDGNCQASHFKCRDSCCIDGYLECDETQDCADGSDEADCERYALEFNNLRKINGTSEQGHCVDLPDTGLCQESITRWYYNPFTQKCSRFTYGGCDGNKNNFEHEEDCMKSCAGVTKSDVIGQRLDFYETQQASLSAFEVAIAVLLGICIMIVLVIIGYYYLKNRKKNSRRRQPATATNSTLSTTEDTEHLVYNSTTKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVW3</accession>
    <name>A0A151MVW3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Upstream stimulatory factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Major late transcription factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Upstream transcription factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">USF2</name>
        <name evidence="13" type="ORF">Y1Q_0013913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004844">
        <property type="protein sequence ID" value="KYO28627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVW3"/>
    <dbReference type="STRING" id="8496.A0A151MVW3"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18923">
        <property type="entry name" value="bHLHzip_USF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000045">
        <property type="entry name" value="upstream stimulatory factor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF2">
        <property type="entry name" value="UPSTREAM STIMULATORY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO28627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="363" mass="39591" checksum="D409B48AD3F7595B" modified="2016-06-08" version="1">MWGHVIVGSCDTSHEKGQEAEEGVELQEGDGSTADEQTAVAIASVQQAAFADHNIQYQFRTENNGGQVTYRVVQVTDSQLDGQTDAAGAVSVVSTAAFTGGQQAVAQAVIQNPFSNGGSPAGDGVSGEARFAYFPASSVGDTTAVSVQTTDQSLAQAGGQFYVMMTPQDVLQTGTQRTIAPRTHPYSPKMDGTRTPRDERRRAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGASKGGILSKACDYIRELRQTNQRMQETFKEAERLQMDNDLLRQQIEELKNENSLLRAQLQQHGIEDPQGGALGLCFLWGKQGCIWLWGGTSRGKPHRMLQGDSRDAAGSRVDQGTATYNSAQRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVZ9</accession>
    <name>A0A151MVZ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004802">
        <property type="protein sequence ID" value="KYO28721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVZ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="94" mass="9980" checksum="212CCC1352158D2D" modified="2016-06-08" version="1">MASCSSLAAALRTAQTESSGLGVRGLVPGSLAGELLSLEHSANLRRGCARAVNVCVAGRRLSQARADSLHAHSRVTPPWKRCSWRPDTANRSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX63</accession>
    <name>A0A151MX63_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Protein pelota homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PELO</name>
        <name evidence="9" type="ORF">Y1Q_0009892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258305.1">
        <property type="nucleotide sequence ID" value="XM_006258243.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX63"/>
    <dbReference type="STRING" id="8496.A0A151MX63"/>
    <dbReference type="GeneID" id="102557765"/>
    <dbReference type="KEGG" id="amj:102557765"/>
    <dbReference type="CTD" id="53918"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MX63"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO29092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="385" mass="43367" checksum="598831D0100C24CD" modified="2016-06-08" version="1">MKLLRKSIEKDNAGQVTLMPEEPEDMWHAYNLLRPGDSLRASTIRKVQTESATGSVGSNRVRTTLTLCVETIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHVCLVTPSMTLTRAKVEVNIPRKRRGSCAQHDRALERFYDQVAQAIQRHINFDVVKCVLVASPGFVREQFCDYMFQQAVKTDNKLLLENRSKFLQVHSSSGHKYALKEALCDPAVANRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKHVEKANEAMAIDTLLISDELFRHQDVATRSRYVKLVDSVKENMGTVRIFSSLHVSGEQLGQLTGVAAILRFPVAELSDEEDESSSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXF8</accession>
    <name>A0A151MXF8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">F-box only protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FBXO32</name>
        <name evidence="10" type="ORF">Y1Q_0017891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274469.1">
        <property type="nucleotide sequence ID" value="XM_006274407.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXF8"/>
    <dbReference type="STRING" id="8496.A0A151MXF8"/>
    <dbReference type="GeneID" id="102560963"/>
    <dbReference type="KEGG" id="amj:102560963"/>
    <dbReference type="CTD" id="114907"/>
    <dbReference type="eggNOG" id="KOG3926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9991467at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MXF8"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22103">
        <property type="entry name" value="F-box_FBXO32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000017">
        <property type="entry name" value="F-box only protein 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123:SF6">
        <property type="entry name" value="F-BOX ONLY PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO29236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="355" mass="41683" checksum="42E55E9749547BFB" modified="2016-06-08" version="1">MPFLGQDWRSPGQSWVKTADGWTRFLDEKSSSYVSDLSSYCKKEDRNKENLFTGMNYDVAAKKRKKDLLNNKTKIQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSSAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVQKVLEDQQNIRLIKELLQTLYQSLCTLVQRVGKSVLVGNINMWVHRMEAILHWQQQLNNIQITRPAFKGTTFTDLPLCLQLNIMQRLTDGRDLVSLGQVAPELQVLSEDRLLWKKLCQYHFTDRQIRKRLILSDKGQLDWKKMYFKLIRCYPKKEQYGDTLQLCRHCHILSWKGTDHPCTANNPESCSISLSPQDFINLFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYP6</accession>
    <name>A0A151MYP6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dysferlin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dystrophy-associated fer-1-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Fer-1-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0004962</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004653">
        <property type="protein sequence ID" value="KYO29565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MYP6"/>
    <dbReference type="KEGG" id="amj:102557639"/>
    <dbReference type="eggNOG" id="KOG1326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002280">
        <property type="term" value="P:monocyte activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050765">
        <property type="term" value="P:negative regulation of phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033292">
        <property type="term" value="P:T-tubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08373">
        <property type="entry name" value="C2A_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000009">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000021">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000026">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000033">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000037">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000061">
        <property type="entry name" value="dysferlin isoform X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037726">
        <property type="entry name" value="C2A_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012560">
        <property type="entry name" value="Ferlin_A-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF44">
        <property type="entry name" value="DYSFERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08165">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01200">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="2088"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="191"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="357"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1159"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1333"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1604"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1838"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2040"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO29565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2123" mass="242261" checksum="5D7BF72D93227AD2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0R9</accession>
    <name>A0A151N0R9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Connector enhancer of kinase suppressor of ras 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CNKSR1</name>
        <name evidence="5" type="ORF">Y1Q_0023554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004201">
        <property type="protein sequence ID" value="KYO30401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0R9"/>
    <dbReference type="STRING" id="8496.A0A151N0R9"/>
    <dbReference type="KEGG" id="amj:102558670"/>
    <dbReference type="eggNOG" id="KOG1738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01260">
        <property type="entry name" value="PH_CNK_mammalian-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051566">
        <property type="entry name" value="CNKSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017874">
        <property type="entry name" value="CRIC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844">
        <property type="entry name" value="CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12844:SF10">
        <property type="entry name" value="CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10534">
        <property type="entry name" value="CRIC_ras_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51290">
        <property type="entry name" value="CRIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIC" evidence="4">
        <location>
            <begin position="73"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="203"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="452"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO30401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="769" mass="84024" checksum="79E5CB9666A356DC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2L1</accession>
    <name>A0A151N2L1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 20">Voltage-dependent calcium channel gamma-1 subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 20">Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CACNG1</name>
        <name evidence="21" type="ORF">Y1Q_0016363</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 20">Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19 20">Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258001.1">
        <property type="nucleotide sequence ID" value="XM_006257939.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2L1"/>
    <dbReference type="STRING" id="8496.A0A151N2L1"/>
    <dbReference type="GeneID" id="102565332"/>
    <dbReference type="KEGG" id="amj:102565332"/>
    <dbReference type="CTD" id="786"/>
    <dbReference type="eggNOG" id="ENOG502QT5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9937541at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990454">
        <property type="term" value="C:L-type voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902514">
        <property type="term" value="P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005421">
        <property type="entry name" value="VDCC_g1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008368">
        <property type="entry name" value="VDCC_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15025:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15025">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01792">
        <property type="entry name" value="VDCCGAMMA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01601">
        <property type="entry name" value="VDCCGAMMA1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 20" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="7 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 20" id="KW-0813">Transport</keyword>
    <keyword evidence="11 20" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU363085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO30967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="224" mass="25231" checksum="7EA1FFC9E0A18F45" modified="2016-06-08" version="1">MDEGKTLKIRLTFSVILVGVALLFAAVVTDHWAVLSPEVLHYNATCEAAHFGLWRLCTKRIYVQDTKEKGCGPISLPGERNCSYFKHFTPGQSAEIFEVSTQREYSISAAAIAIFSVGFAIIGTICVLLSFRKKMDYLLRPASMFYTFSGLCIIISVEVMRQSVKRMIDSDETSWIQYYYSWSFACACASFVLLFVCGIALLLIALPRFPQNPWETCMDAEPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3R2</accession>
    <name>A0A151N3R2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MFSD11</name>
        <name evidence="11" type="ORF">Y1Q_0016544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006269279.1">
        <property type="nucleotide sequence ID" value="XM_006269217.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014457467.1">
        <property type="nucleotide sequence ID" value="XM_014601981.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3R2"/>
    <dbReference type="STRING" id="8496.A0A151N3R2"/>
    <dbReference type="GeneID" id="102576621"/>
    <dbReference type="KEGG" id="amj:102576621"/>
    <dbReference type="CTD" id="79157"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N3R2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17407">
        <property type="entry name" value="MFS_MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF0">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO31219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="448" mass="48985" checksum="93AC7300B07A8112" modified="2016-06-08" version="1">MSSESKKLFNIIILGVAFMFMFTAFQTCGNVAQTVITNLNSTDFHGSGYTSMAIIYGVFSASNLISPSVVAIVGPQISMFVSGIFYSAYIAVFIQPFTWAFYTASVFIGIAAAVLWTAQGNCLTINSDENTIGRNSGVFWALLQFSLFFGNLYIYLAWQGKTHISEGDRRTVFIALTVISLVGTVLFFLIRKPEESNTHEGEDSTNENLGDASSSQSKMTRAVDAFKRSMKLCLTKEILLLSITTAYTGLELTFFSGVYGTCIGAVNKFGSDEKSLIGLSGIFIGIGEILGGGFFGLVNKNNRFGRNPVVILGIVVHFVAFYLIFFNMPNNAPLASIEGTNDQAYMNPSKELAIFCSFLLGLGDSCFNTQLLSILGFLYSEDSAPAFAIFKFVQSICAAVAYFYSNYLLLQWQLLIMVVVGFFGTISFFTVEWEAPAFVARGSDYSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4I9</accession>
    <name>A0A151N4I9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase RNF185</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RING finger protein 185</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RNF185</name>
        <name evidence="17" type="ORF">Y1Q_0022777</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449134.1">
        <property type="nucleotide sequence ID" value="XM_014593648.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4I9"/>
    <dbReference type="STRING" id="8496.A0A151N4I9"/>
    <dbReference type="GeneID" id="102563263"/>
    <dbReference type="KEGG" id="amj:102563263"/>
    <dbReference type="CTD" id="91445"/>
    <dbReference type="eggNOG" id="KOG0823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N4I9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16744">
        <property type="entry name" value="RING-HC_RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000062">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO31681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="194" mass="20829" checksum="5BDE709DD241127C" modified="2016-06-08" version="1">MASKGPTASTSTENSSTGGTSGSSSSNGAGDNTNQDSTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLSRLFLFVALVIMFWLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4Q9</accession>
    <name>A0A151N4Q9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IQCD</name>
        <name evidence="11" type="ORF">Y1Q_0022850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4Q9"/>
    <dbReference type="STRING" id="8496.A0A151N4Q9"/>
    <dbReference type="eggNOG" id="ENOG502QQS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042815">
        <property type="entry name" value="DRC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="228"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021752"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
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            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO31778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="300" mass="34953" checksum="657A0020585851D5" modified="2016-06-08" version="1">MQLGPTRAPRDFAANFDLVRHEIRQKEKSRDLRAQPGAAQAVRDEVYARDLTDELFVRALTEFRGFLLERLLTGPREEEARARLAADVSLRDQRNTEAVAVLRADLAAALHRRDEEICKKNAVIRDLKTHLHHLAKFSENHILRSRQEAEKQQKGELRASQAKCARLQQDIQQLRAQLSALVAENRESELALRKKKYKVEMEIENWIQKYDADMGEKQMEYEEVDTIYTEEKAQLAQLKEIYTVLEQEYSQIKEERRIAQEKKERAERELAIMIRAATRIQAFWKGYLVARADQKACIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5W8</accession>
    <name>A0A151N5W8_ALLMI</name>
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        <recommendedName>
            <fullName evidence="2">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0007106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">KSC_2009_1</strain>
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    </reference>
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    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF10309">
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    </dbReference>
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    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019876"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO32097.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="580" mass="66087" checksum="AFBA510E36399E67" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9F9</accession>
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            <fullName evidence="5">Unc-80-like protein isoform G</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">Y1Q_0008665</name>
    </gene>
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        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="UNC80_central"/>
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        <property type="entry name" value="UNC80_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UNC80"/>
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            <end position="1235"/>
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    <feature type="domain" description="Protein UNC80 central region" evidence="3">
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3076"/>
            <end position="3098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3162"/>
            <end position="3173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="3174"/>
            <end position="3183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3204"/>
            <end position="3215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3224"/>
            <end position="3243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="3375" mass="377333" checksum="643126E070C3E1E8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9W5</accession>
    <name>A0A151N9W5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Shugoshin-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SGOL2</name>
        <name evidence="11" type="ORF">Y1Q_0008777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9W5"/>
    <dbReference type="STRING" id="8496.A0A151N9W5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051177">
        <property type="term" value="P:meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038889">
        <property type="entry name" value="Shugoshin1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577">
        <property type="entry name" value="SHUGOSHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577:SF3">
        <property type="entry name" value="SHUGOSHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="356" mass="40383" checksum="8BF5D32EE511F060" modified="2016-06-08" version="1">MKEERTFKAAKLNASLASKIKSKIRNNSSFFKISLKYNNKALALALSAEKENSRRLKNEKLFLQKEVEELQFHNILLRQKLNCLNKTLIDIEAFLNNNLLTAIKISSLSEHLQSPLPQPYGKNSHVGDPSKISHHSVRSGGMSVKIPLVAAHNAKQKNSPPVCETADDLCKNTAVASNKVCSDKISSELLLSSEKSNSKPNEIEKMETVLDAHVCVKENQPWTELNCSCVFISDTSEIFEKINETPLCANKGGRKFKMPFEGSCQKNLILCNKSQTLQDLTNMKLYPHNSLPETQKNFEENSKTPTRRRKTNICYKEPRLNSKLRRGDQFTDLEFLNSPVFRVKNKRSFKSKPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NA47</accession>
    <name>A0A151NA47_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase p58-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NA47"/>
    <dbReference type="STRING" id="8496.A0A151NA47"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase p58-like C-terminal" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="203" mass="23435" checksum="DDD10FE74EC6AD05" modified="2016-06-08" version="1">MHLKSARFSPFQLVYGHCPRGLLQIVQEEWERPVGPGLVAERYRQELQDRIDKAQQIACQNLQAAQGQQESQYNQKTKPRVFQLEDMVLVSLPASTSTHLTTWQGPFKVIRQVGPVDYEMLKTRHRHECQIYHVKLLKEWKAPQGWLAQKEEAVEELGPPCPKLGGSTGKGQMHLGEDLDADQWWELEEMIETFQDTFQENPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAL1</accession>
    <name>A0A151NAL1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RDH16</name>
        <name evidence="5" type="ORF">Y1Q_0023989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003654">
        <property type="protein sequence ID" value="KYO33811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAL1"/>
    <dbReference type="STRING" id="8496.A0A151NAL1"/>
    <dbReference type="KEGG" id="amj:102572659"/>
    <dbReference type="eggNOG" id="KOG1610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000074">
        <property type="entry name" value="Retinol dehydrogenase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF48">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585887" evidence="4">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO33811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="317" mass="34927" checksum="8B7D9087B6BAD4F8" modified="2016-06-08" version="1">MWLYLAALLALYILRRWYREQQTVGNLPDKYVFITGCDSGFGHLLAKQLDGRGLRVLAACLTEQGAERLRQATSGRLQTVILDVTCSDSIAAATAWVKGQVGDRGLWGLVNNAGIGVPTAPNEWLSKADFVKVLDVNLIGPIEVTLSLLPLVRRARGRVVNVASAVGRLSVTGGGYCPAKYGVEAFSDSLRREIRAFGVKVSIIEPGAFRTPILDTQCIQKGLAQVWSRTPTEVKEAYGQHYFDYYIENIQKIFSSAGPNLHLVTDAMEHALTAQHPRTRYSCGWDAKLFYLPLSYLPTSWADLVLTRNQSKPAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAU6</accession>
    <name>A0A151NAU6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box only protein 36 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FBXO36</name>
        <name evidence="2" type="ORF">Y1Q_0024511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014458289.1">
        <property type="nucleotide sequence ID" value="XM_014602803.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAU6"/>
    <dbReference type="STRING" id="8496.A0A151NAU6"/>
    <dbReference type="GeneID" id="102562538"/>
    <dbReference type="KEGG" id="amj:102562538"/>
    <dbReference type="CTD" id="130888"/>
    <dbReference type="eggNOG" id="KOG1777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22106">
        <property type="entry name" value="F-box_FBXO36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052301">
        <property type="entry name" value="SCF_F-box/WD-repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381">
        <property type="entry name" value="DACTYLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="189" mass="22168" checksum="531523CDDA5D2AD7" modified="2016-06-08" version="1">MASLLPDKLFEARGQAPAPSKDFYQVLVTRSQVIFRWWKISLRSEFRESKPGEIKEAHEDFLDDPSLQIQIAIVFGAKVLEHIFNLCRGNFDFLERLPDPLLLNIISFLGLEDIARLSQVSHRFETICNCDTLWEKIVQNLCDTITPEMKALAQEVGWKRFFFTSKLQLQLQIRRRRQKQDNSEKELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCM7</accession>
    <name>A0A151NCM7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003392">
        <property type="protein sequence ID" value="KYO34557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCM7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="9399" checksum="7ADA98E674271B70" modified="2016-06-08" version="1">MQGQCMLPKTSSWPAGAILWLPTRLRAAGLQQSQEAPRNPAEKQLVTETAGRVSTMGATGLVPLLRGHLSFCCNRVVYTLSLMGGCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ND62</accession>
    <name>A0A151ND62_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">N-alpha-acetyltransferase 20</fullName>
            <ecNumber evidence="9">2.3.1.254</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methionine N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">N-acetyltransferase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">N-terminal acetyltransferase B complex catalytic subunit NAA20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">N-terminal acetyltransferase B complex catalytic subunit NAT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NatB catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">NAA20</name>
        <name evidence="22" type="ORF">Y1Q_0010498</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-terminal L-methionyl-L-asparaginyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50484"/>
            <dbReference type="Rhea" id="RHEA-COMP:12694"/>
            <dbReference type="Rhea" id="RHEA-COMP:12695"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133356"/>
            <dbReference type="ChEBI" id="CHEBI:133358"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-terminal L-methionyl-L-aspartyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50480"/>
            <dbReference type="Rhea" id="RHEA-COMP:12692"/>
            <dbReference type="Rhea" id="RHEA-COMP:12693"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133045"/>
            <dbReference type="ChEBI" id="CHEBI:133063"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-terminal L-methionyl-L-glutaminyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50492"/>
            <dbReference type="Rhea" id="RHEA-COMP:12698"/>
            <dbReference type="Rhea" id="RHEA-COMP:12699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133361"/>
            <dbReference type="ChEBI" id="CHEBI:133362"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N-terminal L-methionyl-L-glutamyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50488"/>
            <dbReference type="Rhea" id="RHEA-COMP:12696"/>
            <dbReference type="Rhea" id="RHEA-COMP:12697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133359"/>
            <dbReference type="ChEBI" id="CHEBI:133360"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.254" evidence="9"/>
    <dbReference type="EMBL" id="AKHW03003332">
        <property type="protein sequence ID" value="KYO34752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006265957.1">
        <property type="nucleotide sequence ID" value="XM_006265895.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ND62"/>
    <dbReference type="STRING" id="8496.A0A151ND62"/>
    <dbReference type="GeneID" id="102573874"/>
    <dbReference type="KEGG" id="amj:102573874"/>
    <dbReference type="CTD" id="51126"/>
    <dbReference type="eggNOG" id="KOG3234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="PhylomeDB" id="A0A151ND62"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000015">
        <property type="entry name" value="N-alpha-acetyltransferase 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="21">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="178" mass="20301" checksum="B18BAC46C77E4F7B" modified="2016-06-08" version="1">MTSLRAFTCDDLFCFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVLEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFB5</accession>
    <name>A0A151NFB5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA delta isomerase 2, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0008065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFB5"/>
    <dbReference type="STRING" id="8496.A0A151NFB5"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000084">
        <property type="entry name" value="Enoyl-CoA delta isomerase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="277" mass="31280" checksum="CC0D50A24E6D675B" modified="2016-06-08" version="1">MVTDHCFCCSKSNLEEVASASSKCKYETLQVSTEDNITKIMLNRPMKKNAVNLVMYREIMQALEEAAKDDSVITVVTGSGDYYSSGNDLNNFTENLEQIIKNNGEWIKNFVNHFIDFPKPLVAVVNGPALGISVTLLGLFDSVYATNRATFQTPFIQLRQTPEGCSTYTFPKIMGTAKANEMLLFNKKLTAREACAQGLVTEVFPDQVFQEEVWRKLKAFASLPKNSLALSKQLIRSVEKEKLYAVNSQECEQIVKKYFSKESMNAFKSFFQKKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFT0</accession>
    <name>A0A151NFT0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maestro-like HEAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003131">
        <property type="protein sequence ID" value="KYO35663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFT0"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF22">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="1">
        <location>
            <begin position="180"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="340" mass="37141" checksum="E7339208D6283144" modified="2016-06-08" version="1">MFNTIVLDGLALVPKESLPSCTLSWCVPRRRVTIYSSLEKVLQRDTKGLDRSLVRRIIHLASRHMRETQSLSQVLEVAYDFQIPLPDGKLENICLAVHNQQVMSILALSAKGHLDLTLSTLEDLGAAMSKMQVSGIVSLLLQDLDLKLTLIQSVTEISCAIQDADGSQFTYKEELLGYMLVPDILGTIFIRMPTIQEGSGRGFLLEGGSTLAGFYLEAVTSSLLSKPLPMDRQTRTSLFGCPGTSVSHSTWLGAWFSMENLACVISKGFGERVAASLCKQGTWPLLQSLETHCEGVCQLARALLPLGIVTPSFIGQVLKWVKAGSQNLRVTGTAFLSQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NH86</accession>
    <name>A0A151NH86_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mast cell protease 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0013148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NH86"/>
    <dbReference type="STRING" id="8496.A0A151NH86"/>
    <dbReference type="KEGG" id="amj:102562017"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000010">
        <property type="entry name" value="Kallikrein related peptidase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF81">
        <property type="entry name" value="GRANZYME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO36114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="18716" checksum="8EF6DE18AC4DC6EC" modified="2016-06-08" version="1">MMEKNRQEIAVRDIIPHENYNRRTKENDIMLLQLARKAKITKTVDLIRLPQANNVLKPGTTCSVAGWGRTGVHIIRPSNKLQEVDLKMGDEEQCRYLYGSFNSTLMICMGDSRDKKSSFKGDSGGPLVCKGIAQGIVSFGKHSGIPPAVYTRVSAYIDWIEENMGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJZ3</accession>
    <name>A0A151NJZ3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LRRC14</name>
        <name evidence="7" type="ORF">Y1Q_0015209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRAME family. LRRC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002874">
        <property type="protein sequence ID" value="KYO37080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267396.1">
        <property type="nucleotide sequence ID" value="XM_006267334.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NJZ3"/>
    <dbReference type="STRING" id="8496.A0A151NJZ3"/>
    <dbReference type="GeneID" id="102564896"/>
    <dbReference type="KEGG" id="amj:102564896"/>
    <dbReference type="CTD" id="9684"/>
    <dbReference type="eggNOG" id="ENOG502QWSJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6479713at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000119">
        <property type="entry name" value="Leucine-rich repeat-containing 14 isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050694">
        <property type="entry name" value="LRRC14/PRAME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224">
        <property type="entry name" value="SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO37080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="511" mass="56767" checksum="A38DCC86FC638A91" modified="2016-06-08" version="1">MHSLVFLCAQKLASHHATARGALEVLPTELYPVLFKAAFLDKRTLVLQDLVQTWPFPVLSFQRLLRRCQHCDRAPLQEKPSKLCVQTVILGVVAYLGAALEGRSHGSGRRHCLRVLDMTGLQDDGTDQGSESMSLWSRTVTLAKACIDVSKQQSKCTQRTSKRRKGPYSSLAALPPPRLVSVEVRVDLFVNSTSYGVLKDALQANAHSALRLRCRDFRAEELSIASTVGLLEFLDPAGVRQVDLRFNNLGLSGLRVVLPHMAKFTNLVSLKLPYSNIDVRRLSAGMEGSLHYFATQLGRLSCLKELNLGSSRLSGRLRQLLGNLQGPLESLELAFCYLLPSDLAYLSQSLHTPALKKLDLSGNNLSDTLLQPFQRLLREAAGSLLHLDIMECRLADTHLEALLPILCCCARLRYLGVFGNPLSTRGLKTLLLRTAGLSDLRLVIYPYPVDCYGEDLPWPPSSSSLLNGSVDEEKFSRVSAELQQMLLSTDRNDAIWTTNLCRHNTLDYFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKQ6</accession>
    <name>A0A151NKQ6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002722">
        <property type="protein sequence ID" value="KYO37382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKQ6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="121" mass="12952" checksum="100505737BE1490B" modified="2016-06-08" version="1">MSRPLLSSFPTTSKQNGKPQDEFYDQASPDKRTEADGNSDPNSGKGAGCIMINYQRLQPLNSAKQPHSPCGQQSSTASVAMAGEGIPTQLPHTLLLSGNQLLFLPPSLLGEKKEGQQKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLA6</accession>
    <name>A0A151NLA6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Platelet-derived growth factor receptor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0010969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PDGFRL, TNK2 and GRB2.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002664">
        <property type="protein sequence ID" value="KYO37568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLA6"/>
    <dbReference type="STRING" id="8496.A0A151NLA6"/>
    <dbReference type="eggNOG" id="KOG0200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NLA6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042495">
        <property type="entry name" value="PDGFRL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360:SF2">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21339">
        <property type="entry name" value="VEGFR-1-like_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="262"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO37568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="373" mass="41426" checksum="F3A37C019DD19F07" modified="2016-06-08" version="1">MRRPQAPEKKATRESKPWVAQGTGRKAKLVSRKPLPKAKPPMNSTAAPGAGKPPVSILSQVVARGQFQKVPESLALQAGDALELRCRGRAVRWRYPAHLQDDEEGRLRVKHYAKFSQLLVVNATAADTGEYSCWSLQCQDSPCQEGEDRTGKTFVFFADPQELFVPTEDYYEVVQLRTNRPTLLPCQVTSPLARVTLHREFPPEEVPVDGRDISYDVRRGFTIHRSRPSYAGSLFCMASLGGVRQISTKYMLVYINYPSSAPKPTVRASGTSPRVGENFIVTCTVLGEPEVAVDFTWEYPGQKVGRPPYVRERTDLVRRGGQVRQEAESTLYVDEARDVDAGLYTCRAENLEGSASATTRVRVLPALWGGQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLW5</accession>
    <name>A0A151NLW5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC83</name>
        <name evidence="2" type="ORF">Y1Q_0004679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002570">
        <property type="protein sequence ID" value="KYO37822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLW5"/>
    <dbReference type="STRING" id="8496.A0A151NLW5"/>
    <dbReference type="eggNOG" id="ENOG502QS0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026702">
        <property type="entry name" value="CCDC83"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21468:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21468">
        <property type="entry name" value="HSD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="418" mass="49006" checksum="CC75ACE1AF8A4F8E" modified="2016-06-08" version="1">MGKKKKKENLEQLYKEARSSFPEALLAFQIQIKEEAIDRLLLELKELEEKNEKYRERNKQLKEEQLGYIKDLLNDLKKHEKLLEEKEVVTRDDVEEAMKEQCQYVRDQEQLLKDLNSQISEYDEKLSVRELEKDYWLEYKNVGSGDHAKQIQILEKDIQALKDDLNEMTEFYRSTLQMTKDKIDRMVEKQKSQKKEWATENAVQHIDKSSCREIKENEWLKEEVEVYKKEVSDLEASAQLLEEENIYMIQILSDRRLQNLRISRPLFLTQGAGLQGEDELLSANLEGLACGEHSGMKDDKNECPKSMELPGAWSMEKAAMSDTQSEMEDSYEFLCGIPMPPTLDSLLYEDEKDFQEYLKLGPLEIKLMIESKKSESFCQLVQLFFLPEHQLDLFLTILAILSPSLLSSSQQWQVQTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPE4</accession>
    <name>A0A151NPE4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C4H2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ZC4H2</name>
        <name evidence="3" type="ORF">Y1Q_0015595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270173.1">
        <property type="nucleotide sequence ID" value="XM_006270111.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPE4"/>
    <dbReference type="SMR" id="A0A151NPE4"/>
    <dbReference type="STRING" id="8496.A0A151NPE4"/>
    <dbReference type="GeneID" id="102574846"/>
    <dbReference type="KEGG" id="amj:102574846"/>
    <dbReference type="CTD" id="55906"/>
    <dbReference type="eggNOG" id="KOG4451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20865at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044069">
        <property type="entry name" value="ZF_C4H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018482">
        <property type="entry name" value="Znf-C4H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058">
        <property type="entry name" value="ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058:SF2">
        <property type="entry name" value="ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10146">
        <property type="entry name" value="zf-C4H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51896">
        <property type="entry name" value="ZF_C4H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C4H2-type" evidence="2">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO38335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="224" mass="26258" checksum="B83924064B4A9013" modified="2016-06-08" version="1">MADEQEIMCKLESIKEIRNKTLQMEKIKARLKAEFEALESEERHLKEYKQEMDLLLQEKMAHVEELRLIHADINVMENTIKQSENDLNKLLESTRRLHEEYKPLKEHVDALRMTLGLQRLPDLCEEEEKLSLDYFEKQKAEWQTEPQEPPIPESLAAAAAAAQQLQVARKQDTRQTATFRQQPPPMKACLSCHQQIHRNAPICPLCKAKSRSRNPKKPKRKQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQC9</accession>
    <name>A0A151NQC9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">THYN1</name>
        <name evidence="8" type="ORF">Y1Q_0022575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002395">
        <property type="protein sequence ID" value="KYO38978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059575523.1">
        <property type="nucleotide sequence ID" value="XM_059719540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQC9"/>
    <dbReference type="STRING" id="8496.A0A151NQC9"/>
    <dbReference type="GeneID" id="102572239"/>
    <dbReference type="KEGG" id="amj:102572239"/>
    <dbReference type="CTD" id="29087"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="7">
        <location>
            <begin position="73"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO38978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="242" mass="27919" checksum="D006E20F289992E2" modified="2016-06-08" version="1">MPWPSRKRSQAAAEDKKKPETKQAKHESHEEEEEEESMPSAAESSKPAKKSSGWAVKKEASSDGQGSKQVYGHWLLKSEPESRFEKGADVKFGIEDLKAEPNQTACWDGIRNYQARNFLRDMKLGQEAFFYHSNCKDPGIVGIVKIVKEFYPDHTQFDKKDPHYDSSSNKEKPKWSMVDVQFVRMTKRFIPLSELKAHHLAHKESGGPLKNMLLFSRHRLSIQPLTKEEFEFILSLEEEKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQM2</accession>
    <name>A0A151NQM2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Splicing factor U2AF subunit isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">U2AF1-1</name>
        <name evidence="15" type="ORF">Y1Q_0000088</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002379">
        <property type="protein sequence ID" value="KYO39074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQM2"/>
    <dbReference type="STRING" id="8496.A0A151NQM2"/>
    <dbReference type="eggNOG" id="KOG2202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000055">
        <property type="entry name" value="Splicing factor U2AF 35 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO39074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="272" mass="31497" checksum="AAF27BAF64504376" modified="2016-06-08" version="1">MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQSADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRKKWQRKVNVTEWQEASDKLVNVKSAGAPLHPARARCDRGGGCRLRHCREGKKPLLEPLEARRLKRCGASWLIKSSARVLHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NR56</accession>
    <name>A0A151NR56_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protocadherin gamma-B2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0008450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002331">
        <property type="protein sequence ID" value="KYO39278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NR56"/>
    <dbReference type="STRING" id="8496.A0A151NR56"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF234">
        <property type="entry name" value="PROTOCADHERIN GAMMA-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="2"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="134"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="255"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="360"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO39278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="510" mass="56959" checksum="BEC117DC508A5077" modified="2016-06-08" version="1">MDGGDPVRTGTAQIRINVTDANDNPPVFAEEVYQVKLKENLPKGSLVLQVQATDKDESSNAEIIYSFNNILDTERQIFNLDTKTGKITTQGIIDFEEKGTYTIGIEARDGGGLSAHCKIDIEILDDNDNAPEVTFTSISTPIPEDSKLGTVIALIKVRDPDATANGEYTCRIPDNLPFKLKYQLQNDKHFSLDLKTRLDVFKRPELVLEKPLDREEQAAHDLILTATDGGDPVRSGTARIHVVVLDANDNAPVFSQPLYRVSVRENVPVGTTVATVKAMDLDEGVNGEVIYTFQKITELVSRIFHLDSGTGDITTAEKLDFEEASLYEMEVQAHDGGGLFDRSKVVISVSDVNDNAPDIRITSLLTSVPEDSPPGTVISLLIVQDQDSGENGAVTCTIPDHVPFRLQKSLDTYYTLVTARDLDREQIAYWVSHIFSLSQLFYSADRYSTHVRASKSCQWLPRWQWEHSGRTSEDHWDLISTLSFICLVFIFELLPLRSIWKWPKGPLWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRB0</accession>
    <name>A0A151NRB0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FEV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FEV</name>
        <name evidence="5" type="ORF">Y1Q_0018062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002222">
        <property type="protein sequence ID" value="KYO39391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRB0"/>
    <dbReference type="STRING" id="8496.A0A151NRB0"/>
    <dbReference type="eggNOG" id="KOG3806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NRB0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000448">
        <property type="entry name" value="FEV (ETS oncogene family)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF307">
        <property type="entry name" value="FEV TRANSCRIPTION FACTOR, ETS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="4">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO39391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="212" mass="23435" checksum="6E302860EA5011FB" modified="2016-06-08" version="1">MRHGAPAQPLLLNMYLPEPVGETLFKDGKSQAWGALNPGVQKGSGQIQLWQFLLELLSDRANLHCIAWEGANGEFKLVDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFQGLAQVCQPPAPDHTLYKLQGNLAPLPFPGISKLNLMASGVAGPGFSYWPSSAPALYPGPGLQPAAPFGSVAASHLNNVNNHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NS04</accession>
    <name>A0A151NS04_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein 37B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">VPS37B</name>
        <name evidence="11" type="ORF">Y1Q_0018696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014454001.1">
        <property type="nucleotide sequence ID" value="XM_014598515.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NS04"/>
    <dbReference type="STRING" id="8496.A0A151NS04"/>
    <dbReference type="GeneID" id="102570009"/>
    <dbReference type="KEGG" id="amj:102570009"/>
    <dbReference type="CTD" id="79720"/>
    <dbReference type="eggNOG" id="KOG3270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10004364at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039702">
        <property type="term" value="P:viral budding via host ESCRT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000003">
        <property type="entry name" value="vacuolar protein sorting-associated protein 37B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF9">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="10">
        <location>
            <begin position="82"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO39642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="289" mass="31794" checksum="87BF331B59C0767D" modified="2016-06-08" version="1">MAADARRLESLSLQQLHELLEDEEQLQALARDMDEAQNVQLSKEVTLASNRSLAEDNLLYQPKLETLKASVIQKYQELQVLFEAYQIKKTKLDSQSSNASLETLLALLQTEGAKIEEDTENMAEKFLDGEVALDSFIDEYQSKRKLAHLRRVKIEKLQDMVLKGQRLPQAQLPLQPRMPEAAPAPAASYPSDVSTPPLVVPRRIPPPPPPAVPAGRFPTPFTAAMASGPAMPYPGAPYPPLPPRSGSGMQLASQVPQPGPPSQFALQHPPALPQRPPPRLPPHPGFILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU71</accession>
    <name>A0A151NU71_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NU71"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO40472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="7793" checksum="C555736671F29475" modified="2016-06-08" version="1">MTGPRGKIPGIHQRTLISSVNCISKFMVNPRLGAAETESSKRRTCRVVSALAVDVVRVRQTSSPIETCGLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUL4</accession>
    <name>A0A151NUL4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prostate stem cell antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0009502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUL4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23553">
        <property type="entry name" value="TFP_LU_ECD_Ly6PGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000037">
        <property type="entry name" value="Si:ch73-28h20.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036:SF18">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6 FAMILY MEMBER PGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586389" evidence="3">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="4">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO40454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="125" mass="13712" checksum="F2415EA22345EC2B" modified="2016-06-08" version="1">MMRTVFSLVFLSSLFVIKSEALQCYTCVGSSEEECNRQGTQRCPGQSDACSLIRGQGNGVMKSCSFKSFCDQARREGSKVPGMSVHCCYSDNCNAKSLGSRSTISASYLPLLVSAMLWHLLFNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NV34</accession>
    <name>A0A151NV34_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UBL5</name>
        <name evidence="3" type="ORF">Y1Q_0013354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001857">
        <property type="protein sequence ID" value="KYO40781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006277112.1">
        <property type="nucleotide sequence ID" value="XM_006277050.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NV34"/>
    <dbReference type="STRING" id="8496.A0A151NV34"/>
    <dbReference type="GeneID" id="102563305"/>
    <dbReference type="KEGG" id="amj:102563305"/>
    <dbReference type="CTD" id="59286"/>
    <dbReference type="eggNOG" id="KOG3493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NV34"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO40781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="8647" checksum="8D35C2EB02A928F3" modified="2016-06-08" version="1">MIEVVCNDRLGKKVRVKCNTEDSIRDLKKLIAAQTGTRWDKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVD0</accession>
    <name>A0A151NVD0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaporin-8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0013384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001857">
        <property type="protein sequence ID" value="KYO40816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVD0"/>
    <dbReference type="STRING" id="8496.A0A151NVD0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023277">
        <property type="entry name" value="Aquaporin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665:SF59">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02020">
        <property type="entry name" value="AQUAPORIN8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO40816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="306" mass="32290" checksum="A00C61F2816862EE" modified="2016-06-08" version="1">MSNFSTLYSCHSPISSNCSSFPEEESQTSTVKHKKLVETPFSHCFADSRSWGRSSMPDLFPYLYLWAVPLGVGIISGARRPKDGSSHQRIFIGDRNGESACLSVITNPEGAGPMGPALAHGFSLGIMVAVLGKISGGHFNPAVTLAALAAGGLSPLLLLPYWLCQLSGGMLGALLAKSMVPEAIFFNRTGGGCMVQDGSTVGMAVCAELTLSFLLLIAVLMGSLAEHSKTPLAPFCIGFALATGILVSGSISGSCLNPARAFGPALISTHWDNHWVYWIGPLTSAVLASVLYRIVLAGRSRRLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW17</accession>
    <name>A0A151NW17_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PGP</name>
        <name evidence="6" type="ORF">Y1Q_0022340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001697">
        <property type="protein sequence ID" value="KYO41102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NW17"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043136">
        <property type="term" value="F:sn-glycerol 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000163">
        <property type="entry name" value="Pyridoxal phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF92">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO41102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="390" mass="41859" checksum="6704C04B87E3E807" modified="2016-06-08" version="1">MRRLPARRATNEAALRRGAAALLRGAMAAEGRSCRRLEAAAARAVLGAADTLLFDCDGVLWRGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAGAPDALARLEAAGKRLCYVTNNSSRTRQAYADKLRRLGFPAAAPRQVFGSAYCAARYLRQALPPGAAAYVLGGAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXALPGPGPADWAQAPLDPAVRAVLVGFDEHFAYAKLCQALRYLLRGGAACLLVGTNRDHRLPLEGGAAIPGTGCLVKAVEVAAEREAFIIGKPSRYIFDCVVSEFDIDPARTIMVGDRLDTDILMGNTCGLTTILTLTGVSTLEEVKSHQESDCPARRNLIPDYYVDSIADLLPALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWQ4</accession>
    <name>A0A151NWQ4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Probable cysteine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">CARS2</name>
        <name evidence="24" type="ORF">Y1Q_0006159</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:78543"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58591"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:78544"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-disulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-disulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:78651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:19120"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:229465"/>
            <dbReference type="ChEBI" id="CHEBI:229521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:78652"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:78627"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58591"/>
            <dbReference type="ChEBI" id="CHEBI:229465"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:78628"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>S-sulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-sulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:78647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:19119"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58591"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:229520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:78648"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:17775"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWQ4"/>
    <dbReference type="STRING" id="8496.A0A151NWQ4"/>
    <dbReference type="eggNOG" id="KOG2007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1910:FF:000010">
        <property type="entry name" value="Cysteinyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF27">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 24" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="23">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00072679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO41307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="527" mass="60361" checksum="F9D5FEC503863F65" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWR3</accession>
    <name>A0A151NWR3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-tubulin complex component 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TUBGCP3</name>
        <name evidence="9" type="ORF">Y1Q_0006167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258871.1">
        <property type="nucleotide sequence ID" value="XM_006258809.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWR3"/>
    <dbReference type="STRING" id="8496.A0A151NWR3"/>
    <dbReference type="GeneID" id="102576348"/>
    <dbReference type="KEGG" id="amj:102576348"/>
    <dbReference type="CTD" id="10426"/>
    <dbReference type="eggNOG" id="KOG2000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NWR3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="251"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="555"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO41317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="907" mass="103803" checksum="EAE06ABD0A8410A7" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYG2</accession>
    <name>A0A151NYG2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 4E type 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EIF4E1B</name>
        <name evidence="3" type="ORF">Y1Q_0013325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001576">
        <property type="protein sequence ID" value="KYO41838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYG2"/>
    <dbReference type="STRING" id="8496.A0A151NYG2"/>
    <dbReference type="GeneID" id="102564304"/>
    <dbReference type="KEGG" id="amj:102564304"/>
    <dbReference type="CTD" id="253314"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO41838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="218" mass="24536" checksum="570156BCA293A1A3" modified="2016-06-08" version="1">MAAVAAGAGAAPAQQQGEAPRRRRAHKEVLVAVPLGKHPLQNRWALWFFKNDKSKMWQANLRLVTKFSTVEDFWALYSHIQLASKLTSGCDYSLFKDGIEPMWEDNRNKCGGRWLITLAKQQRHTELDHFWLETLLCLIGESFDEYSSEVCGAVINIRAKGDKIAVWTCEAEDREGVTHIGRVYKERLGLSSKVVIGYQAHADTATKSGSLTKNKFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYG5</accession>
    <name>A0A151NYG5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0006274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYG5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO41475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="160" mass="18472" checksum="5BC28C2FE03236CB" modified="2016-06-08" version="1">MENPDLAIYADMQAPAIGPVDMLGQNLQLLTQILGSQQQMLDQEQEWRQHSLASFKMPKMTKVDDPEVYIEAFEQHALVIGLDKRYWASQLGALVVGKAQAAYRALSREDALDYESVKEAILYRLEINPEHYRRRFQAKKGPKIRQPRVLLQQLHNLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYM2</accession>
    <name>A0A151NYM2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001549">
        <property type="protein sequence ID" value="KYO41853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYM2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO41853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="13628" checksum="934915C20AF3CCB3" modified="2016-06-08" version="1">MRGYLGSSSCPRPWSQRVSEELQCDRSGAWGRRAPRSRRVCKGVRGLQRSPGQVAKLQSPVSPLTRSADRTHQLLPMLLPGRTSSTCPAPTVFSGLRAPAAASCVPGAPPCKQGFRCWRSPFVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYU8</accession>
    <name>A0A151NYU8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0006370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NLRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYU8"/>
    <dbReference type="STRING" id="8496.A0A151NYU8"/>
    <dbReference type="eggNOG" id="ENOG502SBIG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029495">
        <property type="entry name" value="NACHT-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF19">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14484">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01288">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="105"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO41615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="607" mass="69489" checksum="D54A36D1B5369D41" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYV8</accession>
    <name>A0A151NYV8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">AURKA</name>
        <name evidence="16" type="ORF">Y1Q_0002709</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYV8"/>
    <dbReference type="STRING" id="8496.A0A151NYV8"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="173"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="94"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="251"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="300"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="11">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO42062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="450" mass="51176" checksum="41718139245D2475" modified="2016-06-08" version="1">MALPSLPRVGGLGLRDLRKERPTEAENWRKNRRSMDRTRKENRPGLPTHGVKIPAHVGDGPKRVPVSQLPQSRVPGGAAQAQRVLCPSNLAQRVPVPSQAPKTAASNQKLSHNQRMQQPQPTCVVQTSSRPQAPNNNEKPHHVPVSANQPEKEGTSKPKNQETKKRQWSLDDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKSQLEEAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPRGEVYKELQKLTKFDEQRTANYITELADALSYCHSKRVIHRDIKPENLLLGSNGELKMADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRTHDEKVDIWSLGVLCYEFLVGKPPFEAETYQETYRCISKVEFRYPPFLSEGAKDLISKLLKHNPYHRLPLKDVLEHPWIRENSTKSPASRVSEAAGSRKSEANNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZX3</accession>
    <name>A0A151NZX3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 13 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC13A3</name>
        <name evidence="8" type="ORF">Y1Q_0002770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275295.1">
        <property type="nucleotide sequence ID" value="XM_006275233.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZX3"/>
    <dbReference type="GeneID" id="102569891"/>
    <dbReference type="KEGG" id="amj:102569891"/>
    <dbReference type="CTD" id="64849"/>
    <dbReference type="eggNOG" id="KOG1281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NZX3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017153">
        <property type="term" value="F:sodium:dicarboxylate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF62">
        <property type="entry name" value="NA(+)_DICARBOXYLATE COTRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="73"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="103"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="142"/>
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            <end position="258"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        <location>
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            <end position="563"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO42139.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="605" mass="66887" checksum="B7EC64237058464E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0F9</accession>
    <name>A0A151P0F9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">Y1Q_0000301</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Postsynaptic cell membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="8496.A0A151P0F9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13720">
        <property type="entry name" value="PBP2_iGluR_NMDA_Nr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000066">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 3A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative glutamate receptor ionotropic NMDA 3A"/>
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    </dbReference>
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        <property type="entry name" value="Glu/Gly-bd"/>
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        <property type="entry name" value="Iono_Glu_rcpt_met"/>
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        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
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        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 23" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 23" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 23" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 23" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="13 23" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
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    <keyword evidence="4 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 23" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="27">
        <location>
            <begin position="342"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="26">
        <location>
            <begin position="343"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="789"/>
            <end position="808"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="892"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="850"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="21">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="21">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="642"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00079"/>
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    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00918"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KYO42632.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="937" mass="104436" checksum="BABB9F44ED5EC531" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1A6</accession>
    <name>A0A151P1A6_ALLMI</name>
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        <submittedName>
            <fullName evidence="7">DnaJ-like protein subfamily C member 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DNAJC27</name>
        <name evidence="7" type="ORF">Y1Q_0016648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001328">
        <property type="protein sequence ID" value="KYO42876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258914.1">
        <property type="nucleotide sequence ID" value="XM_006258852.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1A6"/>
    <dbReference type="STRING" id="8496.A0A151P1A6"/>
    <dbReference type="GeneID" id="102566511"/>
    <dbReference type="KEGG" id="amj:102566511"/>
    <dbReference type="CTD" id="51277"/>
    <dbReference type="eggNOG" id="KOG0098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04119">
        <property type="entry name" value="RJL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000019">
        <property type="entry name" value="dnaJ homolog subfamily C member 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000697">
        <property type="entry name" value="DnaJ homolog subfamily C member 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="217"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO42876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="273" mass="30962" checksum="B859D50706552AD2" modified="2016-06-08" version="1">MEANLPKRKETRKSMRIKVISMGNAEAGKSCIIKRYCEKRFVPKYLATIGIDYGVTKVQVRDREIKVNIFDMAGHPFFYEVRNEFYKDTQGVILVYDVGQKESFEALDTWLAEMKQELGPHGNIENIVFVVCANKIDCTKHRCVDESEGRLWAESRGFLYFETSAQTGEGINEMFQTFYSTIIDLCDNGGKRPAMGMSIGFTKEQADTIRRIRSSKDSWDMLGVKPGATRDEVNKAYRKLAVLLHPDKCVAPGSEDAFKAVVNARTALLKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1J8</accession>
    <name>A0A151P1J8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001300">
        <property type="protein sequence ID" value="KYO42941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1J8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="124" mass="14181" checksum="AB6098AE65D2AF10" modified="2016-06-08" version="1">MVSQSHQWDWQQILTNFKYMKLQHIQGRDTNMVLHAMRSVVPYHEEMSRKLLETQTKTQDTQDGDSLHETLIEQSDTDNLALSTAKCQQLQGKGHTLGYFAHAGIFWILGGHFYPASCRSVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2S6</accession>
    <name>A0A151P2S6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Syncollin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SYCN</name>
        <name evidence="10" type="ORF">Y1Q_0016037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Zymogen granule lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Zymogen granule membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001185">
        <property type="protein sequence ID" value="KYO43374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2S6"/>
    <dbReference type="STRING" id="8496.A0A151P2S6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042589">
        <property type="term" value="C:zymogen granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000014">
        <property type="entry name" value="Syncollin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028137">
        <property type="entry name" value="Syncollin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17503">
        <property type="entry name" value="SYNCOLLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17503:SF0">
        <property type="entry name" value="SYNCOLLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15138">
        <property type="entry name" value="Syncollin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO43374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="123" mass="13748" checksum="2B35BF8E443BC1E9" modified="2016-06-08" version="1">MEKLRHNASKECPAPADLKDINGTKLCAQLYADASPYYDQCCGGRVLPVPPGTDMPYLPRDWNDRVSSLVVAPRCELTVWSRRGKEGSTKRFSAGVVYRLQEVRKGLLGDWDDSISAFYCKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P364</accession>
    <name>A0A151P364_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="20">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0017635</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:18106"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Mn(2+)(in) + ATP + H2O = Mn(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66821"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer. Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="20"/>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P364"/>
    <dbReference type="STRING" id="8496.A0A151P364"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02085">
        <property type="entry name" value="P-type_ATPase_SPCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000017">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000106">
        <property type="entry name" value="E1-E2 ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="844"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO43359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="935" mass="102110" checksum="10B41FBD7E345EF5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3E5</accession>
    <name>A0A151P3E5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Atypical kinase COQ8A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Chaperone activity of bc1 complex-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Coenzyme Q protein 8A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">aarF domain-containing protein kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ADCK3</name>
        <name evidence="21" type="ORF">Y1Q_0013547</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3. According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. However, the small molecule kinase activity was not confirmed by another publication. Shows an unusual selectivity for binding ADP over ATP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3E5"/>
    <dbReference type="STRING" id="8496.A0A151P3E5"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF1">
        <property type="entry name" value="ATYPICAL KINASE COQ8A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="20">
        <location>
            <begin position="332"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO43500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="682" mass="75499" checksum="746E1D8253122BBF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P7H2</accession>
    <name>A0A151P7H2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Y1Q_0007347</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with NEDD4 and NEDD4L.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Membrane</location>
            <topology evidence="24">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P7H2"/>
    <dbReference type="STRING" id="8496.A0A151P7H2"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000001">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000001">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000001">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1280.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002247">
        <property type="entry name" value="Cl_channel-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF7">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01116">
        <property type="entry name" value="CLCHANNEL5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0050">Antiport</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18 23" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20 24" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 24" id="KW-0406">Ion transport</keyword>
    <keyword evidence="19 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 24" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="25">
        <location>
            <begin position="661"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="25">
        <location>
            <begin position="751"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00029360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO45037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="821" mass="91387" checksum="3F09CCCF5CBBA15B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9D8</accession>
    <name>A0A151P9D8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0021328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9D8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586817" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO45642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13504" checksum="9F7ECA0CFED7B119" modified="2016-06-08" version="1">MATLISSLIKASYVCFAEALAVPKAGVLCSGDEARGRETEEKTTGMRRSSLTRCGAQRKGILGNQVWEGGRDQAHPTASDMQPASKQLTATENKSNGQSESYKLKIKGPVRKPGSLIITFVEIVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PA27</accession>
    <name>A0A151PA27_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-klotho</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PA27"/>
    <dbReference type="STRING" id="8496.A0A151PA27"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF68">
        <property type="entry name" value="BETA-KLOTHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="64027" checksum="5010D6129DF3A177" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PB09</accession>
    <name>A0A151PB09_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0021823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PB09"/>
    <dbReference type="STRING" id="8496.A0A151PB09"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF345">
        <property type="entry name" value="PROTOCADHERIN-16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO46297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="135" mass="14605" checksum="EC937EF757B6AA1C" modified="2016-06-08" version="1">MPRFAQREYRAHVREDAPPGTAVCRLQAADPDLGANGEVRYALDPRHGDPEGYFAVDERTGVLRLQRPLDREARALHHLVVQARDGGTPPEAASALVSVVVLDVNDNAPAIRLLFLTETGRPQLSEGARPGPTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBC7</accession>
    <name>A0A151PBC7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cathepsin O</fullName>
            <ecNumber evidence="13">3.4.22.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CTSO-1</name>
        <name evidence="17" type="ORF">Y1Q_0021808</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.</text>
            <dbReference type="EC" id="3.4.22.42"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.42" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBC7"/>
    <dbReference type="STRING" id="8496.A0A151PBC7"/>
    <dbReference type="GeneID" id="102566412"/>
    <dbReference type="KEGG" id="amj:102566412"/>
    <dbReference type="CTD" id="1519"/>
    <dbReference type="eggNOG" id="KOG1542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498368at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PBC7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000079">
        <property type="entry name" value="Cathepsin O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018633256" description="Cathepsin O" evidence="15">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="16">
        <location>
            <begin position="105"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO46280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="318" mass="35108" checksum="C35B1C9C2BBCE5FE" modified="2016-06-08" version="1">MQPLALWLVACLLPGGGGPGLLGSHNRTRAPRGGGRQSAEAALWESVKRITNLNSLSSNDNTTAFYGFNQFSHLFPEEFKAVYLRSRPDKLPKYAEVPKRKETPLPKKFDWRDKNVVTEVKNQNTCGGCWAFSVVGGIESAYAIKRNNLEELSVQQVIDCSYNNYGCSGGSTVSALNWLNQTQVKLVKSSEYSFKGQTGLCHYFSLSDFGVSIMGYAAYDFSGQEEEMMRKLVHWGPLAVTVDAISWQDYLGGIIQYHCSSGKANHAVLVTGFDRTGIIPYWIVRNSWGRTWGIDGYARIKIGGNICGIADTVASVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDW5</accession>
    <name>A0A151PDW5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000483">
        <property type="protein sequence ID" value="KYO47139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDW5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="89" mass="10248" checksum="35AA98B9F6D13740" modified="2016-06-08" version="1">MENPDLATYANVQSTAIGPTDVLGQNLQVLTQILDSQQQMLDRQQDWLRHSFVSFKMPKMTRDDNPEAYIKAFEWHALMTGLDKGYWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFN4</accession>
    <name>A0A151PFN4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFN4"/>
    <dbReference type="STRING" id="8496.A0A151PFN4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF84">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31606" checksum="5DC1C7D66CBA9184" modified="2016-06-08" version="1">MTLHLHLSQNQSATVINAYAQTLDSNEEVKKRFYSDLDNTLASIPRDKVILLGDFNTRVGCDHKIWSKNGMRKANADGILLLTKCTQHGLILTDTVFHQKDWFKTTWKHLRLEHWHLLNYIIIQGRDLRDVLVMRAMKGSEDCWTDHRLVHSVMNIHLVSRHWKTQKAAWRWLNITALKDPGQREKVQAQLHSALEQVPTDDDISIQAHWEQLKSAVQDACAQTIGFALRWNQDWFNANDAQIRDLLKWKHAALKLPGKAIHKVKDGSVPPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PG23</accession>
    <name>A0A151PG23_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="19">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MAPK7</name>
        <name evidence="22" type="ORF">Y1Q_0004977</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="19">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03000339">
        <property type="protein sequence ID" value="KYO47894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PG23"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07855">
        <property type="entry name" value="STKc_ERK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000242">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 19 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="34"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO47894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="675" mass="72741" checksum="1C6663ACDB761DA1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGN5</accession>
    <name>A0A151PGN5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat domain-containing protein 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ANKRD29</name>
        <name evidence="2" type="ORF">Y1Q_0018567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000230">
        <property type="protein sequence ID" value="KYO48266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019342725.1">
        <property type="nucleotide sequence ID" value="XM_019487180.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGN5"/>
    <dbReference type="STRING" id="8496.A0A151PGN5"/>
    <dbReference type="GeneID" id="102570369"/>
    <dbReference type="KEGG" id="amj:102570369"/>
    <dbReference type="CTD" id="147463"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PGN5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24120:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24120">
        <property type="entry name" value="GH07239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="301" mass="32364" checksum="74AC23DC7BC6A111" modified="2016-06-08" version="1">MCKMSFKKETPLANAAFWAARKGNLALLQLLLNSGRIDVDCRDSLGTTALMVASNYGHIDCVRELVVQGADINLQRESGATALFFAAQQGHNDVVKFLFEFGASTEFKNKDGGTALLAACQYGHAKVADTLLKHGANIHDQLYDGASALFLAAQGGFLDVIRLLLSSGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDATRNDGTTALLKAANKGYNNVIEELLKFSPTLGLLKNGTTALHAAVLGGSARAVALLLEAGADPNIRNKANELPAELTKNERILRLLRTKEKQRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PH74</accession>
    <name>A0A151PH74_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000190">
        <property type="protein sequence ID" value="KYO48477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PH74"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="138" mass="15553" checksum="6D4CF106FB326CDB" modified="2016-06-08" version="1">MEEGEVPTHYPASDQIKHSPVLTWQGKHCDHQDGLPSCTRGRLLSCHRDSTCQDLEKNQKKRGKWILLALPSVAMVTDSPARGFGASVIYRIKGKLHQTVHFSSAPEVIKKILFRQFIKESMQLGFKVLKAVVKNAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHY6</accession>
    <name>A0A151PHY6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0004086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHY6"/>
    <dbReference type="STRING" id="8496.A0A151PHY6"/>
    <dbReference type="eggNOG" id="KOG1306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010855">
        <property type="term" value="F:adenylate cyclase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026919">
        <property type="entry name" value="ADGRV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46682:SF1">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO48696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="391" mass="43495" checksum="CCD36CB9C4ADB2C7" modified="2016-06-08" version="1">MLLGLELASLNRHQLAMTGRVERPVLCSPLQLFCWNLISFLASAYISQELSQESCSVLGALMHYLYLCQFSWMLIQAVNFWYVLVMNDEHTERRYLVFFVLSWGLPAFVVILLLIILKGAYHQSMAQIYGLVHSDLCFIPNVYAALFTAALVPLMCLVVVFVVFIHAYQVTPQWKAYDDVFRGRTNAAEIPLVLYLFALISITWLWGGLHVAYRHLWMLVFFVIFNSLEGLYVFVVYFILHNQLCCPVKASYTVDMNGHSTPGSPFFTHGSGMPAPGGEISKSTQNLISAMEEVSADWERASLRPASQASAAFKQSPQNGAAFHATGGFSNGSLMTDEESQEFDDLIFALKTGAGLTVGDTDSCHGSQDGGSMANSQIVELRRIPIADTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PI97</accession>
    <name>A0A151PI97_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PI97"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="9812" checksum="15D0C7DA4B931E5A" modified="2016-06-08" version="1">MGRESEWYLEKVQGLPCGISHTYLVGKPGGAAVCPSHTQDHPCTPRRIPANLIIPLLITFPLCCPWNYKYHSLKLGTSRTECGNFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIB3</accession>
    <name>A0A151PIB3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIB3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9983" checksum="3E85A81FC22A992D" modified="2016-06-08" version="1">MKTFCCIWRQDALLEGVVYLDLDSTVWLPGEWWNLDITEHENIVFDLNDVLVESRNLYDFSECRHLLLLELCGETDWLKTSECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZ09</accession>
    <name>A0A151LZ09_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0020115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZ09"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053067">
        <property type="entry name" value="SUSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46879:SF2">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46879">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584606" description="Sushi domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="60"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO17515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="310" mass="34746" checksum="1A7B6987901FC63F" modified="2016-06-08" version="1">MKGQKSGKCMTLCVLAWSSLQFALSDAIGSMAAFTGAGTIMRGFPRDFNNKTNMHSNVSVQCTALVPPRYGSYYAEKGSGISLGSIIVYWCQEGYQLVGNGKLVCLFSNSTSYWSHPPPHCEVIPKPLDKGFRVAVIASLISGVIILTVTISFAVCCWRDRMLRRETSDGQQHSRTFRGRWKARSTGQERKKHKGIFGRLKQNRRLHYRISSLYSSAYPGAFPGRSNQGFQRSQNNLQKLPVQSLCSEIHIYPQVILHPSATPSASMYVHLPQKTGEIPLAVMPCHASFPRDLAPAYYRRYDKHKFLNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0P9</accession>
    <name>A0A151M0P9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0011659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0P9"/>
    <dbReference type="STRING" id="8496.A0A151M0P9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000015">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000148">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO18062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="168" mass="18933" checksum="5E4920F198B86C08" modified="2016-06-08" version="1">MLSRSFCLAITAHAATIQCGPAKEQQLCDVGEFLCHDYATCVSQNWLCDGEPDCPDDSDESLDTCPEEIEFKCPLNHITCIGTNRCIHLSQLCNGAYDCSDGYDEGVHCRELAILRKAKRDTSRKRSMDFNNADFNKLMELVGQVYWEGILRDKRVQKNCQLLKGTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M272</accession>
    <name>A0A151M272_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mu-type opioid receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">OPRM1</name>
        <name evidence="25" type="ORF">Y1Q_0009082</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M272"/>
    <dbReference type="STRING" id="8496.A0A151M272"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151M272"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004979">
        <property type="term" value="F:beta-endorphin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038047">
        <property type="term" value="F:morphine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15090">
        <property type="entry name" value="7tmA_Mu_opioid_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000014">
        <property type="entry name" value="Kappa-type opioid receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000105">
        <property type="entry name" value="Mu_opioid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001418">
        <property type="entry name" value="Opioid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF7">
        <property type="entry name" value="MU-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00537">
        <property type="entry name" value="MUOPIOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00384">
        <property type="entry name" value="OPIOIDR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13 22" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17 22 25" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19 22" id="KW-0807">Transducer</keyword>
    <keyword evidence="9 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="24">
        <location>
            <begin position="86"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO18605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="399" mass="44487" checksum="AC1362ECAF7BA9DB" modified="2016-06-08" version="1">MDSAFPANSSACGPFPPPCPAGAGGNLSARLEEHGWNQSDLCRGGNGSRVAGGGSLCPAPGVSPSMITAITIMALYSVVCVVGLFGNFLVMYVIIRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWIVSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALINIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRIRQNTREHASTANTVDRTNHQLELLEAETTPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2C7</accession>
    <name>A0A151M2C7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly(A)-specific ribonuclease PNLDC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">PARN-like domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Poly(A)-specific ribonuclease domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PNLDC1</name>
        <name evidence="18" type="ORF">Y1Q_0009122</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. May act as a regulator of multipotency in embryonic stem cells. Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2C7"/>
    <dbReference type="STRING" id="8496.A0A151M2C7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000058">
        <property type="entry name" value="PARN like, ribonuclease domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000061">
        <property type="entry name" value="PARN like, ribonuclease domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO18665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="534" mass="61290" checksum="0F5FAC087CD47776" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M344</accession>
    <name>A0A151M344_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M344"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11575" checksum="6AF94D6117236714" modified="2016-06-08" version="1">MTKEPWPCIHIDFAGPFQGSSPSELLMAHHLKTCLDCVNPDLGEGVSRVLLLKKQHINPLLRFFLNLCSATEKIKKQLTINSLEIGRKSEFSRIFTSALIPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3A3</accession>
    <name>A0A151M3A3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho GTPase-activating protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rho-type GTPase-activating protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ARHGAP18</name>
        <name evidence="11" type="ORF">Y1Q_0018948</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with MPHOSPH6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274313.1">
        <property type="nucleotide sequence ID" value="XM_006274251.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3A3"/>
    <dbReference type="GeneID" id="102562438"/>
    <dbReference type="KEGG" id="amj:102562438"/>
    <dbReference type="CTD" id="93663"/>
    <dbReference type="eggNOG" id="KOG2200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27680at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M3A3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04391">
        <property type="entry name" value="RhoGAP_ARHGAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000028">
        <property type="entry name" value="rho GTPase-activating protein 18 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057323">
        <property type="entry name" value="RHG40/28/18_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF6">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25442">
        <property type="entry name" value="Ubiquitin_RHG40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="10">
        <location>
            <begin position="325"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO18995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="666" mass="75964" checksum="CCFAA15500088006" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3K7</accession>
    <name>A0A151M3K7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3K7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8452" checksum="4255D8309D475CA0" modified="2016-06-08" version="1">MTSWRKSDKQVLAPKIEREEIHFLSRCCCFRRNYREQPGGTGGRDQVRKEGDCGKQRRRRQRRRAGLGQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6C0</accession>
    <name>A0A151M6C0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6C0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="90" mass="9748" checksum="FB94008EAD527C22" modified="2016-06-08" version="1">MLTALFCVEIGSGILVDAGHIHILNYHQLVEDHKSCMEKTVLNEVAGHPCAPVGSAIPEQTASPTLGKHGKMRFAFSDFSSPDPHFPLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M771</accession>
    <name>A0A151M771_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Deoxyguanosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DGUOKL</name>
        <name evidence="14" type="ORF">Y1Q_0010888</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxycytidine + a ribonucleoside 5'-triphosphate = dCMP + a ribonucleoside 5'-diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="2.7.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyguanosine + ATP = dGMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19201"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57673"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.113"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M771"/>
    <dbReference type="STRING" id="8496.A0A151M771"/>
    <dbReference type="GeneID" id="102575265"/>
    <dbReference type="KEGG" id="amj:102575265"/>
    <dbReference type="eggNOG" id="KOG4235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M771"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004136">
        <property type="term" value="F:deoxyadenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004137">
        <property type="term" value="F:deoxycytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004138">
        <property type="term" value="F:deoxyguanosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000461">
        <property type="entry name" value="Deoxycytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF48">
        <property type="entry name" value="DEOXYCYTIDINE KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="13">
        <location>
            <begin position="29"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="33"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO20372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="267" mass="31159" checksum="95B92FF45C1F2737" modified="2016-06-08" version="1">MRPSAKRPCLGPSEPDSLDSSFQKRLTKVSIEGNIASGKSTFVRLLEKYSEEWEVIPEPIAKWCNVQSTDNEYKELTSSQKNGGNLLGMLYDKPTRWAYTFQTFACLSRVKAQLKAASAKLQEAEHPVQFYERSVFSDRYVFASNLFESGCINETEWAIYQDLHTWFLTTFEPDMQLDGIIYLRATPEKCMERLQIRGREEEQGIEMEYLESLHHKHETWLHERTIKVDFDNLREIPILVLDVNEDFKNDKIKQEDLIDKVKAFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9A4</accession>
    <name>A0A151M9A4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0258 KIAA1024-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0001396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MINAR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9A4"/>
    <dbReference type="STRING" id="8496.A0A151M9A4"/>
    <dbReference type="eggNOG" id="ENOG502QSCS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039706">
        <property type="entry name" value="MINAR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009626">
        <property type="entry name" value="MINAR1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530:SF2">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1 MINAR1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06789">
        <property type="entry name" value="MINAR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Major intrinsically disordered Notch2-binding receptor 1-like C-terminal" evidence="8">
        <location>
            <begin position="577"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="734" mass="82750" checksum="1403A7E6EEB68F68" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9T5</accession>
    <name>A0A151M9T5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0001519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9T5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584900" evidence="1">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="9608" checksum="CCF2B434A2C3BC9E" modified="2016-06-08" version="1">MPWLLKSWNYNLTLVLTACSWKYGNNKQTWKIGFDVKVCMEVLVRIQRELHKYRVLELKSTVFMTELNKNFRLFYSDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9U6</accession>
    <name>A0A151M9U6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer dense fiber protein 3-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ODF3L1</name>
        <name evidence="1" type="ORF">Y1Q_0001546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9U6"/>
    <dbReference type="STRING" id="8496.A0A151M9U6"/>
    <dbReference type="GeneID" id="102562013"/>
    <dbReference type="CTD" id="161753"/>
    <dbReference type="eggNOG" id="ENOG502S2VQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429991at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF3">
        <property type="entry name" value="OUTER DENSE FIBER PROTEIN 3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="272" mass="30175" checksum="00B1FA6E67364DDB" modified="2016-06-08" version="1">MEISRAKSKTITFGNGGCRPSATEASGVKRFPPISSKIKGPGPAKYARKPCTGFMNHDFTMFAEPAYTMHIKHTGKTLTDVVSPGPCYFVDPHVSRFGKQKIPLSVIFDREREPKPSGVPAPNAYYRENVHPPGEPHAPAYSLGVYTCYHKYDPNPAPNRYNHTNVLGPKLPVKSSAPCYSMASRLDSGGYAEDLATGPGPAFVSRPEPNVYLNRQPAYSMREKYEPYRERLPGPADYKAEHVTITKLRAPDFSFGIRHSNYLTPLIVDVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MA81</accession>
    <name>A0A151MA81_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hepatic triacylglycerol lipase</fullName>
            <ecNumber evidence="8">3.1.1.3</ecNumber>
            <ecNumber evidence="6">3.1.1.32</ecNumber>
            <ecNumber evidence="7">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lipase member C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Phospholipase A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="38" type="primary">LIPC</name>
        <name evidence="38" type="ORF">Y1Q_0001644</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="38 39" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity. Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates. In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38391"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:38392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40475"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:35020"/>
            <dbReference type="ChEBI" id="CHEBI:76478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40476"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
            <dbReference type="ChEBI" id="CHEBI:76083"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:38700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38511"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41384"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64563"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:38652"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40499"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64765"/>
            <dbReference type="ChEBI" id="CHEBI:74617"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:40500"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 35">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="38">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="8"/>
    <dbReference type="EC" id="3.1.1.32" evidence="6"/>
    <dbReference type="EC" id="3.1.1.5" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263902.1">
        <property type="nucleotide sequence ID" value="XM_006263840.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MA81"/>
    <dbReference type="STRING" id="8496.A0A151MA81"/>
    <dbReference type="ESTHER" id="allmi-a0a151ma81">
        <property type="family name" value="Hepatic_Lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="102563015"/>
    <dbReference type="KEGG" id="amj:102563015"/>
    <dbReference type="CTD" id="3990"/>
    <dbReference type="eggNOG" id="ENOG502QVTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034185">
        <property type="term" value="F:apolipoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01758">
        <property type="entry name" value="PLAT_LPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000010">
        <property type="entry name" value="hepatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000101">
        <property type="entry name" value="Hepatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002333">
        <property type="entry name" value="Lipase_hep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF2">
        <property type="entry name" value="HEPATIC TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00824">
        <property type="entry name" value="HEPLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="33" id="KW-0106">Calcium</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0345">HDL</keyword>
    <keyword evidence="11" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="33" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="39" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="12 36" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="36">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584849" description="Hepatic triacylglycerol lipase" evidence="36">
        <location>
            <begin position="22"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="37">
        <location>
            <begin position="350"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="32">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EMBL" id="KYO21433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="498" mass="57379" checksum="36A740B5E3E2D724" modified="2016-06-08" version="1">MRHFPFFSLLLFFCLGAQANADGGKKKEALDSQHRYTRMKKDQRNLQTKFRLYTDPAEEGCLIVFNQMETLDRCNFNSSVPLVMIVHGWSVDGMLESWVWKMAATLKSKHKEINVMIADWLSFAHQHYPIAVQNTRNIGQDIAGFLEWLEDSIQFSRSDVHLIGYSLGAHVSGFAGSYISGTNKIGRITGLDPAGPLFEGMSPTDRLSPDDANFVDAIHTFTKQHMGLSVGIEQPVAHFDFYPNGGTFQPGCHIMHVYNHIAQYGITGITQTVKCAHERSVHLFIDSLLHDDKQSMAYWCNDIHKFDKGMCLSCRKNRCNTLGYHIRKERLQKSRRLFLKTRANMPFKVYHYQFKIHFINEIQEKQVEPTFTVSLIGTKEDVENLPTTLVEGITGNKTYSFLITLDIDIGELMMIKFKWEGTAVWENLWDRVQTIIPWSKGIYRPGLIVKTIRVKAGETQQKMTFCSQSIDNIHLHPSQEKTFVRCENRPRRLKRKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBA6</accession>
    <name>A0A151MBA6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox protein aristaless-like 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ALX4</name>
        <name evidence="18" type="ORF">Y1Q_0000495</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Binds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274146.2">
        <property type="nucleotide sequence ID" value="XM_006274084.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059578753.1">
        <property type="nucleotide sequence ID" value="XM_059722770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBA6"/>
    <dbReference type="STRING" id="8496.A0A151MBA6"/>
    <dbReference type="GeneID" id="102561960"/>
    <dbReference type="KEGG" id="amj:102561960"/>
    <dbReference type="CTD" id="60529"/>
    <dbReference type="eggNOG" id="KOG0490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000127">
        <property type="entry name" value="homeobox protein aristaless-like 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF322">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 13 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 13 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="10 13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="188"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="17">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="13">
        <location>
            <begin position="190"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO21808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="385" mass="41949" checksum="E09A908B8A82BE22" modified="2016-06-08" version="1">MNADTCVSYCDPAAMESYYNAASQSTEGSSPFRAFQASDKFSPAFLASKGQGFGDSSSKCRSRYSQQECQSLDGSGQAPSSAGAQGSFNKYPAQQQQHLYMQRGPCKTPPESNLKLQETSGHNGALPVPCYGKESNLGEADLQPSSDPSGMDSSYLSVKEAGVKVPQDRASTDLPSPMDKTDSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWIGNNGAASPVPACVVPCDTVPSCMSPHAHPHAAGGVSEFLSVSSPGSHVGQTHMGSLFGTAGISPGLNGYELNSEPDRKTSSIAALRMKAKEHSAAISWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBU3</accession>
    <name>A0A151MBU3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">T-complex protein 11-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TCP11L1</name>
        <name evidence="4" type="ORF">Y1Q_0000618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBU3"/>
    <dbReference type="eggNOG" id="ENOG502QW4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04446">
        <property type="entry name" value="DEP_DEPDC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04405">
        <property type="entry name" value="RhoGAP_BRCC3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF15">
        <property type="entry name" value="T-COMPLEX PROTEIN 11-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO21971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119274" checksum="858323945E67021A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MC61</accession>
    <name>A0A151MC61_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PTPN5</name>
        <name evidence="10" type="ORF">Y1Q_0000728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MC61"/>
    <dbReference type="STRING" id="8496.A0A151MC61"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14613">
        <property type="entry name" value="PTPc-N5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000020">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008356">
        <property type="entry name" value="Tyr_Pase_KIM-con"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01778">
        <property type="entry name" value="KIMPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="183"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="355"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO22126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="448" mass="51172" checksum="A2D74DEA36CF2DBB" modified="2016-06-08" version="1">MSYLLMPFGQFMSNPGGDLTRDGSSVMSYFLLSLISLGLLLVGALIWHLLKAQRDPAFPLPEDRRQSVSRQPSFTYSEWTEDKNEDDFLDLDPVPETPVFDCVMDIKAETDPTTLTVKSVGLQERRGSNVSLTLDMCTPGCSEQGFGYIMSPREQSAREYLQTATNILTEEELHKKALDPFILQAEFFEIPMNFIDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSTDQDDPLSSYINANYIRGYGGEEKVYIATQGPIVNTVSDFWRMVWQECSPIIVMITNIEEMNEKCTEYWPEDQVTYEGIEITVNHVIQADDYRLRLITLKKDEEVRTLKHYWYTSWPDQKTPDQAPALLQLVQEVEEAMQHAEQKNVPVIVHCSAGIGRTGCFIATSICCKELKNEGIVDILRTTCQLRLDRGGMIQTCEQYQFVHHVMSLYGKQLARAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ME44</accession>
    <name>A0A151ME44_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">28S ribosomal protein S6, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRPS6</name>
        <name evidence="4" type="ORF">Y1Q_0003280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ME44"/>
    <dbReference type="STRING" id="8496.A0A151ME44"/>
    <dbReference type="eggNOG" id="KOG4708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO22798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="163" mass="18810" checksum="102A02BCD6361D34" modified="2016-06-08" version="1">MPRYELALILKVMQRPETAATLKRTVEALMERGAVVRNLENLGERSLPYKITKHSQRHSRGGYFSIDFEGPPTIISTMMDHLGRDIDIIRQKLGETDRLPSRIVLRPLLVNKSPECLGTEEAALKMMNGTCLNVQDFQEDPSSTYRFLTIYLQHHHHYLQFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ME97</accession>
    <name>A0A151ME97_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Single-minded-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SIM2</name>
        <name evidence="13" type="ORF">Y1Q_0003298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006278763.1">
        <property type="nucleotide sequence ID" value="XM_006278701.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ME97"/>
    <dbReference type="STRING" id="8496.A0A151ME97"/>
    <dbReference type="GeneID" id="102565409"/>
    <dbReference type="KEGG" id="amj:102565409"/>
    <dbReference type="CTD" id="6493"/>
    <dbReference type="eggNOG" id="KOG3559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19739">
        <property type="entry name" value="bHLH-PAS_SIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000017">
        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000047">
        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000007">
        <property type="entry name" value="single-minded homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010578">
        <property type="entry name" value="SIM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF19">
        <property type="entry name" value="SINGLE-MINDED HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06621">
        <property type="entry name" value="SIM_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51302">
        <property type="entry name" value="SIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Single-minded C-terminal" evidence="12">
        <location>
            <begin position="336"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO22819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="768" mass="86991" checksum="AD92DB6909C239E0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEY3</accession>
    <name>A0A151MEY3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RPL12</name>
        <name evidence="11" type="ORF">Y1Q_0005533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds directly to 26S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MEY3"/>
    <dbReference type="KEGG" id="amj:102563268"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO23065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="147" mass="15702" checksum="8CEE785223686450" modified="2016-06-08" version="1">MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIVSIARQMRHRSLARELSGTIKEILGTAQSVGCSIDGRHPHDIIDDINNGSVECPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGM7</accession>
    <name>A0A151MGM7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC1A4</name>
        <name evidence="11" type="ORF">Y1Q_0002304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGM7"/>
    <dbReference type="STRING" id="8496.A0A151MGM7"/>
    <dbReference type="eggNOG" id="KOG3787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015195">
        <property type="term" value="F:L-threonine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF20">
        <property type="entry name" value="NEUTRAL AMINO ACID TRANSPORTER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585083" description="Amino acid transporter" evidence="10">
        <location>
            <begin position="21"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO23675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="446" mass="47366" checksum="E2A4652AB512A1CA" modified="2016-06-08" version="1">MLKMIILPLVVCSLVSGAASLDTRALGKLGGIAITYFLGTTLLASGLAVALAFIIRPGAGAASLNTNALGLEDTVATSKETVDSFLDLTRNLFPSNLVAAAFRSYATDYKMVSRNTTTGNVTIEKVPIGKEIEGMNILGLVLFALVLGVALKKLGREGEDLIRFFNSFNEATMVLVSWIMWYVPIGIMFLVGSKIVEMEDITLLVTSLGKYIFASILGHVIHGGIILPLIYFAFTRKNPYSFLLGLIMPFATAFATCSSSATLPSMIKCTEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVDLNAGQIFTILVTATASSVGAAGVPSGGVLTIAIILEAIGLPTNDLSLILAVDWIVDRTTTVVNVEGDALGAGILHYLNQKEMKNKEQDLKEVNVEAIPNCKSEGETSPLVTHMNQASNPASTVEPPSKESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJ59</accession>
    <name>A0A151MJ59_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intermediate filament family orphan 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IFFO2</name>
        <name evidence="6" type="ORF">Y1Q_0023251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJ59"/>
    <dbReference type="eggNOG" id="ENOG502QW7N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14516">
        <property type="entry name" value="1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14516:SF1">
        <property type="entry name" value="INTERMEDIATE FILAMENT FAMILY ORPHAN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="104"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO24564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="419" mass="47952" checksum="7D163B17D90ED5F5" modified="2016-06-08" version="1">MTRGRGFVAAPKPLEGRGYAEGRALKRRGQVEGRGYPDGEAFRLYSEEARGAWPPYSRLPGTIWSYTQVRRTGGGGLETLQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLESMVETLQEEAQEAEAIQEELNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVASKKKERKLTSDDDLSEQDGDNSRFSDDEVSCSLNITDEMKRMFNQLRETFDFDDDCDSLTWEENEETLLLWEDFTNCNPSIDLQGEEENLGNLIHETESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVASSDSGNTDEIQDEFDREADVEPMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ML10</accession>
    <name>A0A151ML10_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005917">
        <property type="protein sequence ID" value="KYO25212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ML10"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="132" mass="14326" checksum="D94CE360D19C5993" modified="2016-06-08" version="1">MVQSLVYYWCSQHTWAAPAVGGGDPEPASLLGLVASPSRLDVDPAEAEDRSLTLSYDIVRGKPRLPCNLSLYLEGYLLQHYMSLCPTAEEDIAVCINTFLGMFVTFITTYLNGTGQRGLLGFLSATGRVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMJ8</accession>
    <name>A0A151MMJ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="18">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Y1Q_0023570</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMJ8"/>
    <dbReference type="STRING" id="8496.A0A151MMJ8"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000002">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF28">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO25744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="473" mass="53638" checksum="432FB593C9E2A881" modified="2016-06-08" version="1">MLFGTQSHSLGYFNAVFPYNVKMMKFAWDNYKLYALGKNELRPLTKNGHIGNMFGGLRGATVIDALDTLYIMELEEEFQEAKKWVEKSFDLNVNGEASLFEVNIRYVGGLLAAYYLTGEEMFKSKALELGEKLLPAFNTPTGIPRGVINLGSGMSWSWGWASAGSSILAEFGTLHLEFLHLTELSGNPVFTEKVMNIRKVLNRIEKPQGLYPNFLSPVTGNWVQHHVSIGGLGDSFYEYLIKSWLMSDKRDAEAKKMYNDALEAIEKHLVKKSAGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAEHAGGEQKQQYMDLAAEITHTCHESYSRSDTKLGPEAFRFDSGTEATATRLSERYYILRPEVVESYLYMWRLTHDPKYRQWGWEVVQALEKHCRVEAGYSGIRDVYTTTPTHDNMQQSFFLAETLKYLYLLFCEDDVLSLEDWVFNTEAHPLPVNHTNFKAKASVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN69</accession>
    <name>A0A151MN69_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN69"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9125" checksum="58B1C94EB6FE792F" modified="2016-06-08" version="1">MMSSSHAIPSCRQKQLMNHAGVLSQSGSSGPSIFAMGTQNGGTTLTDSDQHWLLHSMSSSYLYSESKLPLRKWMMHPCAIGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN94</accession>
    <name>A0A151MN94_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN94"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8652" checksum="1AE5BDC29ACC2043" modified="2016-06-08" version="1">MTQATFWDLVEQAWAHLECQDINMWLPLPADTNLAITLFKLAMHTSLQYDGHLFGVGKATTREAILEVSSYFRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR11</accession>
    <name>A0A151MR11_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein TOPAZ1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Testis- and ovary-specific PAZ domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TOPAZ1</name>
        <name evidence="10" type="ORF">Y1Q_0019382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR11"/>
    <dbReference type="STRING" id="8496.A0A151MR11"/>
    <dbReference type="eggNOG" id="ENOG502QPIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048137">
        <property type="term" value="P:spermatocyte division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038952">
        <property type="entry name" value="TOPAZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029435">
        <property type="entry name" value="TOPAZ1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35671">
        <property type="entry name" value="PROTEIN TOPAZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35671:SF1">
        <property type="entry name" value="PROTEIN TOPAZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14669">
        <property type="entry name" value="Asp_Glu_race_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Protein TOPAZ1" evidence="9">
        <location>
            <begin position="577"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO26974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="980" mass="111238" checksum="0BD0B411536713A2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR96</accession>
    <name>A0A151MR96_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spire-like protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005422">
        <property type="protein sequence ID" value="KYO27055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR96"/>
    <dbReference type="STRING" id="8496.A0A151MR96"/>
    <dbReference type="KEGG" id="amj:106737539"/>
    <dbReference type="OrthoDB" id="10043757at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF5">
        <property type="entry name" value="PROTEIN SPIRE HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO27055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="169" mass="19054" checksum="E18A2245DAF60D43" modified="2016-06-08" version="1">MINVRKVLVKAEMEKFLQSKELYQSLRKGKICCCCRAKFPLFSWPASCLFCKRSVCSSCSLKIKMPSKKLAHIPVYALGFETVLGTLPAKVLPVRRRDAFHSLRGTGWRGVEQEFPHIYAHGSVLKDVCSDCTSFVADVISSSRKSVDILNTTPHRSRKTQSLYIDPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRL3</accession>
    <name>A0A151MRL3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Peregrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0007749</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the copine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005292">
        <property type="protein sequence ID" value="KYO27177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MRL3"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05512">
        <property type="entry name" value="Bromo_brd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15701">
        <property type="entry name" value="ePHD_BRPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15676">
        <property type="entry name" value="PHD_BRPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20156">
        <property type="entry name" value="PWWP_BRPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000007">
        <property type="entry name" value="Bromodomain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000013">
        <property type="entry name" value="copine-9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042008">
        <property type="entry name" value="BRPF1_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049583">
        <property type="entry name" value="BRPF1_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042061">
        <property type="entry name" value="Peregrin_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF112">
        <property type="entry name" value="COPINE-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 13" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="107"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="481"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="732"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="786"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="17">
        <location>
            <begin position="1102"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="20">
        <location>
            <begin position="1548"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="504"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="578"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="909"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1301"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1319"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1402"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1458"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1505"/>
            <end position="1518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO27177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1677" mass="189516" checksum="B46A9B6A55E48B6D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSU4</accession>
    <name>A0A151MSU4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSU4"/>
    <dbReference type="STRING" id="8496.A0A151MSU4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027922">
        <property type="entry name" value="PRAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15314">
        <property type="entry name" value="PRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585428" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="142" mass="15996" checksum="46E38758C5099CBF" modified="2016-06-08" version="1">MNWLILLIGSAVFHIHAASQVQNDVKEMEIPSEQDLIKEIVLGRRAIEPPEEEGKNADIDPEIGTFFNHAQIGRATRSTGDPPAPMNAEPAAMLEEDRDHIYHAHNEAEGGKVPIEEMILLPDMVNGLEEDRDHLYHDNREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTM2</accession>
    <name>A0A151MTM2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Interferon regulatory factor 6 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IRF6</name>
        <name evidence="11" type="ORF">Y1Q_0020978</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005066">
        <property type="protein sequence ID" value="KYO27853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014456607.2">
        <property type="nucleotide sequence ID" value="XM_014601121.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTM2"/>
    <dbReference type="STRING" id="8496.A0A151MTM2"/>
    <dbReference type="GeneID" id="102572029"/>
    <dbReference type="CTD" id="3664"/>
    <dbReference type="eggNOG" id="ENOG502QRNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9856880at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00103">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000003">
        <property type="entry name" value="Interferon regulatory factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000093">
        <property type="entry name" value="Putative interferon regulatory factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019817">
        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019471">
        <property type="entry name" value="Interferon_reg_factor-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF9">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10401">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01243">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00601">
        <property type="entry name" value="IRF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51507">
        <property type="entry name" value="IRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="10">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO27853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="493" mass="55799" checksum="6E1293ED5BCF1A66" modified="2016-06-08" version="1">MEIQDTALGGEPGESGTSIIITSASAGNENGTIMALHPRRVRLKPWLVAQVDSGLYPGLVWLNREVKRFQIPWKHATRHSPQHEEENTIFKAWAVETGKYQEGVDEPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPIKIYEVCDIPQSQGSIINPGSTGSAPWDEKDNDLDDEEEEELNPSQHIPIQDTFPFLNINDSPMAPASVESCSTEAAWSKNEPVDMEMPPSTLQHDFFSSPELWISSLPMTDLEIKFEYRGKETGPTSTVSNPQGCRLFYGELGPMPDQEELFGPISLEQVKFPGTEQITNEKQKIFTSRLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSSTTPNLIERQKKVKLFCLETFLSELIAHQKGQMEKQPPFEIYFCFGEEWPDGKPRDRKLIVVQVIPIVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAHLKQLYRLLQTHQDTWPMPAPNMQITQPLPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MW05</accession>
    <name>A0A151MW05_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diamine acetyltransferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0005132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004830">
        <property type="protein sequence ID" value="KYO28680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MW05"/>
    <dbReference type="STRING" id="8496.A0A151MW05"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO28680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="149" mass="16000" checksum="C37CC4FEB4A9E458" modified="2016-06-08" version="1">MACVVRQAQAQDCNALLAMIHGIAEHHQLRHQVPIGAPDLQADGFGPNPFYHCLLAELLPGPGEVPGPPNLYMEALYQGRGIGRTLLSEVAKVSLAHGCVEMKLMVMEGNHQAAAFYQGLGACDTTADEGWHCVELGGLALYRLAEEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MX39</accession>
    <name>A0A151MX39_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endothelial cell-specific molecule 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ESM1</name>
        <name evidence="12" type="ORF">Y1Q_0009903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO29106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006268844.1">
        <property type="nucleotide sequence ID" value="XM_006268782.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MX39"/>
    <dbReference type="STRING" id="8496.A0A151MX39"/>
    <dbReference type="GeneID" id="102565748"/>
    <dbReference type="KEGG" id="amj:102565748"/>
    <dbReference type="CTD" id="11082"/>
    <dbReference type="eggNOG" id="KOG1218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9868586at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005171">
        <property type="term" value="F:hepatocyte growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902204">
        <property type="term" value="P:positive regulation of hepatocyte growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.40.20:FF:000002">
        <property type="entry name" value="Endothelial cell-specific molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038850">
        <property type="entry name" value="ESM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15428:SF0">
        <property type="entry name" value="ENDOTHELIAL CELL-SPECIFIC MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15428">
        <property type="entry name" value="ENDOTHELIAL CELL-SPECIFIC MOLECULE 1 ESM-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585545" description="Endothelial cell-specific molecule 1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO29106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="185" mass="20668" checksum="ACB1381652715CE1" modified="2016-06-08" version="1">MKSFLFFTIILVLVHIRTAWSAKYAVDCPEPCDSNECKSTLRCKRTVLDDCGCCRVCAATLGETCYRTVSGMDGVKCGPGLKCQFYTEEDDFGDEFGICKECPYGTYGIECRKTCNCQSGICDRVTGKCLKFPFFQLSASKPPNRRKIISYTDNDMASGDGNAVKEEFVKEKGIDSPVMKWLNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYH5</accession>
    <name>A0A151MYH5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0022940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004633">
        <property type="protein sequence ID" value="KYO29587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYH5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16594">
        <property type="entry name" value="RING-HC_TRIM7-like_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF14">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO29587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="10873" checksum="5A21A6DB1BC62E38" modified="2016-06-08" version="1">MATQALAENLQDELSCYICLEFFKDPVSIHCGHNFCQACITKCWEESGVNFSCPQCREGCPGVQGPNPGLTAGSEGREREASAVSSNRRSEEPGVSGKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZ06</accession>
    <name>A0A151MZ06_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acylglycerol lipase</fullName>
            <ecNumber evidence="3">3.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ABHD6</name>
        <name evidence="20" type="ORF">Y1Q_0023129</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:75539"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes glycerol monoesters of long-chain fatty acids.</text>
            <dbReference type="EC" id="3.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Late endosome membrane</location>
            <topology evidence="13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Lysosome membrane</location>
            <topology evidence="14">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion membrane</location>
            <topology evidence="15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZ06"/>
    <dbReference type="STRING" id="8496.A0A151MZ06"/>
    <dbReference type="eggNOG" id="KOG1454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000082">
        <property type="entry name" value="monoacylglycerol lipase ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="19">
        <location>
            <begin position="65"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO29750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="330" mass="37672" checksum="2CCAD1CCFF77C13F" modified="2016-06-08" version="1">MFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRALGMQVRYAYYDDYQFCYSYRGRPGNKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDYSINGQVKRIHEFVECIKLNRKPFHLVGTSMGGNVAGVYAAQYPAEVCSLSLVCPAGLPYPTDNKFRKFLRELKESEGIDRIPLIPSTPEEMAEMLKLCSYVRFKVPQQILQGLVDVRIPHNEFYRKLFLEIVNEKSVYKLHENMRKIKAPTQVIWGKQDQVLDVSGADVLANSIPDCHVHILENCGHSVVVERPRKTAKLILEFLALVHNAENSKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZ34</accession>
    <name>A0A151MZ34_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LGALS9L</name>
        <name evidence="5" type="ORF">Y1Q_0016285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004550">
        <property type="protein sequence ID" value="KYO29679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZ34"/>
    <dbReference type="STRING" id="8496.A0A151MZ34"/>
    <dbReference type="GeneID" id="102566059"/>
    <dbReference type="KEGG" id="amj:102566059"/>
    <dbReference type="eggNOG" id="KOG3587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000562">
        <property type="term" value="P:negative regulation of CD4-positive, alpha-beta T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032689">
        <property type="term" value="P:negative regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000124">
        <property type="entry name" value="Galectin-4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF186">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="192"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO29679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="320" mass="35258" checksum="DED02FD124BDD6F0" modified="2016-06-08" version="1">MALQQPIMNPTIPFSGPIFGGLVEGKMLLIQGQVGSQGKRFAVNLRCANNDIAFHFNPRFDESRPVVVCNTEQGRHWGPEERTYVMPFQHGTYFEMITKVQGHCYQVAVNGQQFLEYRHRVPFLSVQILEISGDVTVNCISFTGALVTPACAPPPYGMVPGSASGVIFHQMFGPPAPGRKGPVTVSNPNVPFQAALLRGPHTPLKITIVGNVPSNANRFHVNLKNALTGNTALHINPRLREGALVRNTQTSGSWGSEERHVSTMPFAAGQAFQMEIKSTATCYRVMVNGRHAFDYNYRIPDNQVDQMEVDGDVGLSYVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1K2</accession>
    <name>A0A151N1K2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1K2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO30654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="117" mass="13320" checksum="7D667F5AFBAE40A3" modified="2016-06-08" version="1">MIPAPKNLKEKCYIPSTLDLMGVHPTETACTIREIVSCISLKFGQKSTTALEEWPTRFSDSSKAYHCPNLHQLHPGSTVLSKTSHSTELPPLLFLTLRVDWEYLPWFGLWVPFKMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1P3</accession>
    <name>A0A151N1P3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Caspase recruitment domain-containing protein 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CARD-containing MAGUK protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CARD11</name>
        <name evidence="16" type="ORF">Y1Q_0008335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Homodimer; disulfide-linked. Homomultimer; polymerizes following activation, forming a nucleating helical template that seeds BCL10-filament formation via a CARD-CARD interaction. Interacts (via CARD domain) with BCL10 (via CARD domain); interaction takes place following CARD11 activation and polymerization, leading to the formation of a filamentous CBM complex assembly. Component of a CBM complex (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260697.2">
        <property type="nucleotide sequence ID" value="XM_006260635.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1P3"/>
    <dbReference type="STRING" id="8496.A0A151N1P3"/>
    <dbReference type="GeneID" id="102559767"/>
    <dbReference type="KEGG" id="amj:102559767"/>
    <dbReference type="CTD" id="84433"/>
    <dbReference type="eggNOG" id="KOG0708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8868836at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050700">
        <property type="term" value="F:CARD domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032743">
        <property type="term" value="P:positive regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050870">
        <property type="term" value="P:positive regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050862">
        <property type="term" value="P:positive regulation of T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06736">
        <property type="entry name" value="PDZ_CARD11_CARD14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000148">
        <property type="entry name" value="Caspase recruitment domain family member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000136">
        <property type="entry name" value="Caspase recruitment domain family member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000003">
        <property type="entry name" value="Caspase recruitment domain family, member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000770">
        <property type="entry name" value="Caspase recruitment domain family, member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14559:SF4">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="15">
        <location>
            <begin position="59"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="505"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="214"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO30721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1207" mass="139397" checksum="487CD204C866680B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1Z7</accession>
    <name>A0A151N1Z7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1Z7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="8710" checksum="26CEE63A4E626295" modified="2016-06-08" version="1">MAPESQIRLFTDLGREKGRDLPPPPILKPSKREENADPSTRVCAAESSRDGELGSAFPPLHNNISHPSRFRSQLMRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3W0</accession>
    <name>A0A151N3W0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">GDH/6PGL endoplasmic bifunctional protein</fullName>
            <ecNumber evidence="22">1.1.1.363</ecNumber>
            <ecNumber evidence="8">1.1.1.47</ecNumber>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">H6PD</name>
        <name evidence="27" type="ORF">Y1Q_0006086</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-deoxy-D-glucose 6-phosphate + NAD(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62064"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:84760"/>
            <dbReference type="ChEBI" id="CHEBI:145420"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:62065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:84760"/>
            <dbReference type="ChEBI" id="CHEBI:145420"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:62069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:12557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-galactose 6-phosphate + NAD(+) = 6-phospho-D-galactono-1,5-lactone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62076"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91004"/>
            <dbReference type="ChEBI" id="CHEBI:145419"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:62077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>D-galactose 6-phosphate + NADP(+) = 6-phospho-D-galactono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:91004"/>
            <dbReference type="ChEBI" id="CHEBI:145419"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:62073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:62088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:145423"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:62089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14293"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:14294"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glucose + NADP(+) = D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14405"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:14406"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38215"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.363"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:38216"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.363"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-glucose 6-sulfate + NADP(+) = 6-sulfo-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62080"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145424"/>
            <dbReference type="ChEBI" id="CHEBI:145427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:62081"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.363" evidence="22"/>
    <dbReference type="EC" id="1.1.1.47" evidence="8"/>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3W0"/>
    <dbReference type="STRING" id="8496.A0A151N3W0"/>
    <dbReference type="eggNOG" id="KOG0563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000015">
        <property type="entry name" value="Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF7">
        <property type="entry name" value="GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="24">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="26">
        <location>
            <begin position="142"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="25">
        <location>
            <begin position="484"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00061271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00066973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00068889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO31513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="715" mass="81595" checksum="C9B83BB83566AA80" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5P5</accession>
    <name>A0A151N5P5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat and SOCS box-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">WSB1-1</name>
        <name evidence="8" type="ORF">Y1Q_0007149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5P5"/>
    <dbReference type="STRING" id="8496.A0A151N5P5"/>
    <dbReference type="GeneID" id="102576171"/>
    <dbReference type="KEGG" id="amj:102576171"/>
    <dbReference type="CTD" id="26118"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N5P5"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051983">
        <property type="entry name" value="WSB_SOCS-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622:SF12">
        <property type="entry name" value="WD REPEAT AND SOCS BOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="7">
        <location>
            <begin position="377"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO32154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="421" mass="47089" checksum="CAA788B74C50C5DA" modified="2016-06-08" version="1">MASFPLDVNEKLIARSRTIGELLAPTSPFDKKCGRENWTVAFAPDGSYFAWSQGHRIVKLVPWSQCLNNFLLHGTKNVANSVNSRLSRQNSDSGQKSKPCEHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFKFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLMDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYACAFSPDSSILCSVGASKAVFLWDMDKYSMIRKLEGHHNDVVACEFSPDGALLATASYDTRVYVWDPHIGAILMEFGHLFPPPTPIFAGGANDRWVRSVTFSHDGLHIASLADDKMVRFWRIDEEYPVQVAPLNNGLCCAFSTDGSVLAAGTQDGSVYFWATPKHVPSLQHLCRMAIRRVMPTSQVKNLPIPLKVVEFLSYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6H3</accession>
    <name>A0A151N6H3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vasorin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VASN</name>
        <name evidence="8" type="ORF">Y1Q_0020349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274800.1">
        <property type="nucleotide sequence ID" value="XM_006274738.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6H3"/>
    <dbReference type="STRING" id="8496.A0A151N6H3"/>
    <dbReference type="GeneID" id="102565930"/>
    <dbReference type="KEGG" id="amj:102565930"/>
    <dbReference type="CTD" id="114990"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N6H3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000211">
        <property type="entry name" value="vasorin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF160">
        <property type="entry name" value="VASORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585775" evidence="6">
        <location>
            <begin position="19"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="410"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="673" mass="75026" checksum="98AF3E7340C20975" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N769</accession>
    <name>A0A151N769_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003905">
        <property type="protein sequence ID" value="KYO32660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N769"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="86" mass="9993" checksum="418A1309CBAA88E1" modified="2016-06-08" version="1">MHATETDDLVISSWLQKMLVQQGFKQLHNLKQMSNPIACLDHALRNWRARQLFLCHEDLEILGNGSQIKRETKKMSCHVAHLSQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N892</accession>
    <name>A0A151N892_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein phosphatase 1 regulatory subunit 12C isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PPP1R12C</name>
        <name evidence="13" type="ORF">Y1Q_0011023</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the troponin T family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003823">
        <property type="protein sequence ID" value="KYO33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N892"/>
    <dbReference type="STRING" id="8496.A0A151N892"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21945">
        <property type="entry name" value="IPD_PPP1R12C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000004">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000283">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000001">
        <property type="entry name" value="Troponin T, fast skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF27">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="582"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="751"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="872"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1005"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129721" checksum="9B4FA5842E640409" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8M0</accession>
    <name>A0A151N8M0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copine-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Copine V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CPNE8</name>
        <name evidence="16" type="ORF">Y1Q_0014956</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8M0"/>
    <dbReference type="STRING" id="8496.A0A151N8M0"/>
    <dbReference type="GeneID" id="102576771"/>
    <dbReference type="KEGG" id="amj:102576771"/>
    <dbReference type="eggNOG" id="KOG1327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N8M0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000117">
        <property type="entry name" value="copine-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000013">
        <property type="entry name" value="copine-9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF51">
        <property type="entry name" value="COPINE-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="166"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="333"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="588" mass="65499" checksum="C66158795B3CB245" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N913</accession>
    <name>A0A151N913_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonucleoside-diphosphate reductase subunit M2</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ribonucleotide reductase small chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribonucleotide reductase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RRM2B</name>
        <name evidence="16" type="ORF">Y1Q_0011305</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03003826">
        <property type="protein sequence ID" value="KYO32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N913"/>
    <dbReference type="STRING" id="8496.A0A151N913"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF20">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="370" mass="42874" checksum="23C5B68701661B18" modified="2016-06-08" version="1">MKHLALSDKENTPPTLSSTRILASRAARKIFQDADAKPAPPEPVPHRPEDEPLLRENPRRFVIFPVQYHDVWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEEKYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKDREFLFNAIETLPCVKKKADWALRWIGDRKATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVKEIISNAVIIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKIYRAENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSKPTDNSFTLDAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N948</accession>
    <name>A0A151N948_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protease serine 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMPRSS13</name>
        <name evidence="12" type="ORF">Y1Q_0006450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003697">
        <property type="protein sequence ID" value="KYO33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019347913.1">
        <property type="nucleotide sequence ID" value="XM_019492368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N948"/>
    <dbReference type="STRING" id="8496.A0A151N948"/>
    <dbReference type="GeneID" id="102573646"/>
    <dbReference type="KEGG" id="amj:102573646"/>
    <dbReference type="CTD" id="84000"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10012881at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N948"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF27">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15494">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 7 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="244"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="481" mass="53301" checksum="3CF9E89F9FB4C35E" modified="2016-06-08" version="1">MDRDTSPDTPPPPSSNAAEPSASPRSHPLTARSAQPRENVRGISFKPNALEARPAPPAPVARENTTAGPPALQFKAPRCMSQKRLALIFCICVLILLLIALILLFMFWRSQTGIVHKEPVEVCKDNAVRCDGVVECSQKSDELDCVRFGWDQSLLHVYSGAESQWLPVCSSTWNDSFSRKTCKQLGYQNVFLTEFIPLRFSGKSLSVTADHRTIQQSLNSSSCSTGKYVSLRCTSCGQRTSSRIVGGTEAPVNRWPWQASLQYGPVHICGGTIIDAQWVLTAAHCFFMNSVKILDDWKVYVGSSDLRQRTEGISVSRIIINTNYSDDQDDYDIALMKLSRPLTLSANIRPACLPMYGQKFLTSRSCFITGFGKIKETEENTTPKLREAEVKLIDYRICNSNDVYEGYLTPRMMCAGYLEGGRDSCQGDSGGPLVCEDNGRWYLAGVTSWGTGCGQPNKPGVYTQVTKFLSWIQSKMESESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9U5</accession>
    <name>A0A151N9U5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0008748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N9U5"/>
    <dbReference type="eggNOG" id="KOG3628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000003">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000004">
        <property type="entry name" value="Disco interacting protein 2 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000002">
        <property type="entry name" value="Disco interacting protein 2 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF34">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1509" mass="164792" checksum="C00D641A64D0D394" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NA49</accession>
    <name>A0A151NA49_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60 kDa heat shock protein, mitochondrial</fullName>
            <ecNumber evidence="3">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Chaperonin 60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Heat shock protein 60</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HSPD1</name>
        <name evidence="15" type="ORF">Y1Q_0008798</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NA49"/>
    <dbReference type="STRING" id="8496.A0A151NA49"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000019">
        <property type="entry name" value="60 kDa heat shock mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000026">
        <property type="entry name" value="Chaperonin 60 subunit alpha 2 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000018">
        <property type="entry name" value="Heat shock protein 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
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    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
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    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO33651.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
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    </evidence>
    <sequence length="519" mass="55227" checksum="450F825A44C4B985" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBE0</accession>
    <name>A0A151NBE0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Myoneurin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MYNN-1</name>
        <name evidence="15" type="ORF">Y1Q_0024657</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">KSC_2009_1</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="8496.A0A151NBE0"/>
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    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18217">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000472">
        <property type="entry name" value="myoneurin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000678">
        <property type="entry name" value="Myoneurin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="myoneurin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000051">
        <property type="entry name" value="myoneurin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="73"/>
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        <location>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="381"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="200"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="570"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="217"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="236"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074683"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO34077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="672" mass="75096" checksum="66E5698EE65CD317" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCH7</accession>
    <name>A0A151NCH7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0007743</name>
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    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003549">
        <property type="protein sequence ID" value="KYO34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCH7"/>
    <dbReference type="STRING" id="8496.A0A151NCH7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585937" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="141" mass="15551" checksum="CF5D8F417B601FB3" modified="2016-06-08" version="1">MIYCFNIAYFLLAVTGVQSKVEYVASGGTVKMLGDSLGISCTTSGIDFDNSWLGWVRHVPGRGLQQVAYISKLAGDTVYYSDAVKGRFTISRDNSRKLLHLQMSNLRPEDAAEYYCSWVAQCAGLCVNQDKNLALRLSGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCK9</accession>
    <name>A0A151NCK9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003396">
        <property type="protein sequence ID" value="KYO34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCK9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="134" mass="14920" checksum="F321FA833AA87D44" modified="2016-06-08" version="1">MVPDSAEDQQSPEYQALFPVLPPGWGVTEERAGTHLTSSLTFTPTLQDHWECTAEPVIRTLQTWGRIYIPAPSQARDVKSYSVESELCLPTGPEEDGVEHLCCVEHEVLKKPKFRASGQLWLQGHSETTKASNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCR9</accession>
    <name>A0A151NCR9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003392">
        <property type="protein sequence ID" value="KYO34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCR9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="82" mass="8840" checksum="6F87F088504887C7" modified="2016-06-08" version="1">MPVPGSGPEQPFGSEVCLQTCESALVLSGTAAQKAVFVGGFCEARYQQAEDPCETYLWQLLLFACCCHSLQPICPTSNRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ND18</accession>
    <name>A0A151ND18_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleoside diphosphate kinase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NME6</name>
        <name evidence="14" type="ORF">Y1Q_0017093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003349">
        <property type="protein sequence ID" value="KYO34711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ND18"/>
    <dbReference type="STRING" id="8496.A0A151ND18"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045839">
        <property type="term" value="P:negative regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037994">
        <property type="entry name" value="NDPk6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO34711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="129" mass="14422" checksum="F100C2E5B9BB92A7" modified="2016-06-08" version="1">MASGPMRAYILAHEDAVVRWRCLMGPTRVSRARNTAPDSIRGAYGLTDTRNATHGSDSAASASKEIAFFFPEFDERRWYQEDEPRLRCGQARYSAEERVHQVWMQVQPLDATGASGRPELLPAGRGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDB5</accession>
    <name>A0A151NDB5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ciliary microtubule inner protein 2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FAM166B</name>
        <name evidence="9" type="ORF">Y1Q_0007567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CIMIP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003329">
        <property type="protein sequence ID" value="KYO34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDB5"/>
    <dbReference type="STRING" id="8496.A0A151NDB5"/>
    <dbReference type="KEGG" id="amj:102571415"/>
    <dbReference type="OrthoDB" id="2019884at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22146:SF8">
        <property type="entry name" value="PROTEIN FAM166B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="8">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="8">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="302" mass="33025" checksum="915550CED92F48EC" modified="2016-06-08" version="1">MATAFAPKISQVLMTPDPHHIPGYAGYCPQYKFRLGRTYGKLTSQLLTCPEVARSPHLVLQPTQGPCGNAQPPEQEEKLLEVPRAGWGAGILPVSCSMIPGYTGFIPRAQHFFAKTYLEICKEARSDFARQQRRSWGGQEQPRACQPCLDPAQGSKEPAAGIPGSDHRLLPTVMGMAPLPAAAAPHGSPYSMEDDNPHKYFISGFTGFVPRARFLIGAGFPITTHRALLEFARMSRKDGSKPRAMGTSSLLPPLGRTYPTAGGLLPNYTGYIPGYKFQFGRTYGHLTHDALHLGLPEKQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFX0</accession>
    <name>A0A151NFX0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rubicon Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0021150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003197">
        <property type="protein sequence ID" value="KYO35549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFX0"/>
    <dbReference type="STRING" id="8496.A0A151NFX0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="5">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO35549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="177" mass="20631" checksum="3102937AB1ACD1A2" modified="2016-06-08" version="1">MRYLALMLSRPVLKLREINPLLFNYVEELVEIRKLRQDILLMKPYFITCKEAMEARLLLQLQDRQHFVENDEMYSLQDLVDVQAGRLGCSLTEIHTLFAKHIKLDCERCQAKGFVCELCKEGDVLFPFDSHTSVCTDCSAVFHRDCYYDNSTTCPKCARLTLRKQLLFRDPSAKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGT9</accession>
    <name>A0A151NGT9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0011985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003034">
        <property type="protein sequence ID" value="KYO35997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGT9"/>
    <dbReference type="STRING" id="8496.A0A151NGT9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000521">
        <property type="entry name" value="Krueppel-like factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF111">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO35997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="13134" checksum="D4740CB3207498C8" modified="2016-06-08" version="1">MEEGSCLYSGGRALTYFSRGERPFPCTWPECNKKFARSDELARHYRTHTGEKKFACPLCEKRFMRSDHLTKHARRHPAFHPSMVKRPGCHSISPSDSAPSSLAGSPAASPAPSPAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHW5</accession>
    <name>A0A151NHW5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Target of Myb protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TOM1</name>
        <name evidence="8" type="ORF">Y1Q_0024150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TOM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHW5"/>
    <dbReference type="STRING" id="8496.A0A151NHW5"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14236">
        <property type="entry name" value="GAT_TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16995">
        <property type="entry name" value="VHS_Tom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000001">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000003">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014645">
        <property type="entry name" value="TOM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF32">
        <property type="entry name" value="TARGET OF MYB1 MEMBRANE TRAFFICKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036948">
        <property type="entry name" value="TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="7">
        <location>
            <begin position="215"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO36402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="499" mass="54802" checksum="3626801A3F1B1ADB" modified="2016-06-08" version="1">MEFLLGNPFSSPVGQRIEKATDGSLQNEDWALNMEICDIVNETEEGPKDAFRAIKKRIVGNKNFHEVMLALTVLETCVKNCGHRFHILVASHDFVEGVLVRTILPKNNPPTIVHDKVLTLIQSWADAFRSSPDLTGVVSVYEDLRRKGLEFPMTDLDMLSPIHTPQRTVYSPDSPSGQNSPAANSPQGMESILHPVTLPAEPSTPSDAPITPTLEQIGKLRSELEVVNGNVKVMSEMLTELVPSQAEPSDLELLQELNRTCRAMQQRVLELIPRILHEQLTEELLLVNDNLNNVFLRYERFERLRTGRSAKVPNEVENNLVNLEPSAPSTVRQPEATSNLSAQLAGMSLGSGSVSAGLRSLDTSGKLEDEFDMFALTRGSSLAEQRKEVKYEDPQATEGLAGALDARQQSTGAIPVPQAAFMEDIEQWLSTDVGAEPEGAKGVTSEEFDKFLEERAKAADQLPTLPSPSGGMPTPPATSNPHRKREKEDDAMVITGNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKW1</accession>
    <name>A0A151NKW1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RUVBL2</name>
        <name evidence="17" type="ORF">Y1Q_0008407</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Dynein axonemal particle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274926.1">
        <property type="nucleotide sequence ID" value="XM_006274864.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKW1"/>
    <dbReference type="STRING" id="8496.A0A151NKW1"/>
    <dbReference type="GeneID" id="102557970"/>
    <dbReference type="KEGG" id="amj:102557970"/>
    <dbReference type="CTD" id="10856"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NKW1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="67"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO37125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="461" mass="51155" checksum="E881703BCCF28FA7" modified="2016-06-08" version="1">MTTTTTKVPEVRDVTRIERIGAHSHIRGLGLDDALEPRQVSQGMVGQLAARRAAGVILEMIKEGKIAGRAVLIAGQPGTGKTAIAMGMAQALGLDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGAKVGKLTLKTTEMETIYDLGTKMIESLTKEKVQAGDVITIDKATGKITKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEVIPGVLFIDEVHMLDIECFSFLNRALESDMAPVLIMATNRGITRIRGTNYRSPHGIPIDLLDRLLIISTSPYSDKETKQILKIRCEEEDVEMNEDAYTVLTRIGLETSLRYAIQLITAANLVCRKRKGTEVQVEDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGENMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLY9</accession>
    <name>A0A151NLY9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0017881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002581">
        <property type="protein sequence ID" value="KYO37803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLY9"/>
    <dbReference type="STRING" id="8496.A0A151NLY9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF14">
        <property type="entry name" value="TRANSPORTER 2, ATP BINDING CASSETTE SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586180" description="ABC transmembrane type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO37803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="131" mass="14679" checksum="EC0DCA958E8A1B18" modified="2016-06-08" version="1">MFSLSWLNLCLSWLLFSSLVHQDLTFFQQVKTDLTSHLSKDTAPICHSVPANANIFLHSLVVALGLYSFMLGLLWHLTLLTLLEMPLTMATHKIYDACYQAMLQAIQDSVACSGEVAHEAVASMETVQLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NN70</accession>
    <name>A0A151NN70_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NN70"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10210" checksum="9A87746596BA208F" modified="2016-06-08" version="1">MLAVSLPGLPAAQLPGLQCARFKNAERLQMFSSCLWLLKAPCFPASCKCLTSFSIQVLESPAMRCWMMMSSPPVHVFSSWFCPLYLIVHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NN86</accession>
    <name>A0A151NN86_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NN86"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8051" checksum="BD267361FB7CC1EA" modified="2016-06-08" version="1">MNICEVPSPTKKRIMLKLDPSRMKLETPVDLLGPDTEQSALKSNLRNIVRGMLLTYDCLLHPSFPTIFKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNI8</accession>
    <name>A0A151NNI8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 25 member 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC25A43</name>
        <name evidence="11" type="ORF">Y1Q_0015498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNI8"/>
    <dbReference type="STRING" id="8496.A0A151NNI8"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="173"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO38209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="319" mass="35683" checksum="F069491B0F75A377" modified="2016-06-08" version="1">MEMGGNLSVKALGTKSQAEVYVTCHPSQLEKPRTGRTGLRALWKGNLTACLRLGPYSALQLAAYRRFVALFTDDLGHISQWHAIMAGSLAGMVATVATYPTDVIKTRLIVQNRLEPSYKGILHAFYTIYHQEGFLALYRGVSSTVLGTIPFSAGSLFVYINLDKIWREPSNHFTPLQNFINGCLAAGVAQTLSFPFETVKRKMQAQSPYLPHYGGVDVHFTGMIDCFRQTVKHKGVLGLWSGLTASLLKVVPYFGIMFSTFEFCKRVCLYRNGYIESPLSYKLTPGVDQSLQPQELQELKLLRRGNFESRKLQAKETHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPL1</accession>
    <name>A0A151NPL1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPL1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="107" mass="11821" checksum="310AE6B7FA55F462" modified="2016-06-08" version="1">MENLEDDGKARQSPQNNCALLVRGEMHLQNILWDQICALLRSSAILRLDNSSQSVDPSLKEKTCILGLEMLMMDNSWIGCEGGIEACTGQGIKQGAHEWSNLLCSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPT4</accession>
    <name>A0A151NPT4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PFKFB3</name>
        <name evidence="13" type="ORF">Y1Q_0023469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006274611.1">
        <property type="nucleotide sequence ID" value="XM_006274549.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPT4"/>
    <dbReference type="STRING" id="8496.A0A151NPT4"/>
    <dbReference type="GeneID" id="106736698"/>
    <dbReference type="KEGG" id="amj:106736698"/>
    <dbReference type="CTD" id="5209"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000047">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF41">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="254"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO38788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="515" mass="59346" checksum="9E33E5A8F9EBA728" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQE5</accession>
    <name>A0A151NQE5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Semaphorin-3D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0023413</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQE5"/>
    <dbReference type="STRING" id="8496.A0A151NQE5"/>
    <dbReference type="eggNOG" id="KOG3611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038191">
        <property type="term" value="F:neuropilin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05871">
        <property type="entry name" value="Ig_Sema3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11252">
        <property type="entry name" value="Sema_3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000015">
        <property type="entry name" value="Semaphorin 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000030">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000001">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041416">
        <property type="entry name" value="IL-1RAcP-like_ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042582">
        <property type="entry name" value="Sema3D_Sema"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF36">
        <property type="entry name" value="SEMAPHORIN-3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18452">
        <property type="entry name" value="Ig_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586271" description="Semaphorin-3D" evidence="11">
        <location>
            <begin position="25"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="13">
        <location>
            <begin position="32"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="552"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="726"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO38715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="88614" checksum="4FE8D4578792579D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQH7</accession>
    <name>A0A151NQH7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQH7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="12267" checksum="F0B3EFAE3BA079B6" modified="2016-06-08" version="1">MASSCHRACFYCISVVLREWRNILEIIGRYDLERAYPVVSSTCKASLMGYLYPAERELVLLNGAAWDTEQQHMAGRVLPEGCCAPAWTLGTGPKYNTGYKVDPRMKDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRF9</accession>
    <name>A0A151NRF9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002195">
        <property type="protein sequence ID" value="KYO39426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRF9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO39426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7653" checksum="489260B068911A3C" modified="2016-06-08" version="1">MDLALEDLSSRRLFLAFRYHCGMKCLRTPIKRRIMASSHVSRVILLIMTTSQRKECIKTKVLSVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRJ8</accession>
    <name>A0A151NRJ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pantothenate kinase 3</fullName>
            <ecNumber evidence="5">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pantothenic acid kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0004885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the type II pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03002337">
        <property type="protein sequence ID" value="KYO39259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRJ8"/>
    <dbReference type="STRING" id="8496.A0A151NRJ8"/>
    <dbReference type="KEGG" id="amj:102560784"/>
    <dbReference type="eggNOG" id="KOG2201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275583at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24137">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000025">
        <property type="entry name" value="pantothenate kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000001">
        <property type="entry name" value="pantothenate kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF21">
        <property type="entry name" value="PANTOTHENATE KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO39259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="370" mass="41140" checksum="79B0DAC87798B249" modified="2016-06-08" version="1">MKIKDAKKPSFPWFGMDIGGTLVKLAYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRKGNLHFIRFPTHDLPTFIQMGRNKNFSTLHTVLCATGGGAYKFEEDFRTIGNLQLHKLDELDCLVKGLLYIDSVSFNGQAECYYFENASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTHADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSIARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRK0</accession>
    <name>A0A151NRK0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FUN14 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FUNDC1</name>
        <name evidence="9" type="ORF">Y1Q_0000107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002379">
        <property type="protein sequence ID" value="KYO39095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267178.1">
        <property type="nucleotide sequence ID" value="XM_006267116.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRK0"/>
    <dbReference type="STRING" id="8496.A0A151NRK0"/>
    <dbReference type="GeneID" id="102573647"/>
    <dbReference type="KEGG" id="amj:102573647"/>
    <dbReference type="CTD" id="139341"/>
    <dbReference type="eggNOG" id="KOG4099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF2">
        <property type="entry name" value="FUN14 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO39095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="156" mass="17185" checksum="7DE676128CFC7D3C" modified="2016-06-08" version="1">MAARQPRSASDHESDDESYEVLDLTEYARRHHWWNRVFGRNSGPIVEKYSVATQIAMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQVDWKRVEKDVNKAKKQLKKRANKAAPEINTLIEESTEFIKQNIVVSSGFVGGFLLGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRM3</accession>
    <name>A0A151NRM3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002229">
        <property type="protein sequence ID" value="KYO39383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRM3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="363" mass="39206" checksum="B03260FFD9D8D44A" modified="2016-06-08" version="1">MRKLPMSCSCKDRKESVQRVPVSKLFPVCEQSGVEFAVPPRRGCLNDVLLWCPTPAHATRPPTHLSLEPELGAAVMTCSFLSEDGANRCKLVFALEEKTQGLEDWVCMLHYIKEKEDYMDRSYERQLKCCCSGVCVWSYFQGKAIGSGKGAVPGDSPEPVPALEQIAGHWGHQWITAPSGLRGSRGPCFGASGCARGSPSPYRVQLPPRPQQIYGCGAHQGGSSWTRPGRGRAEGCSLGLLVEPEAPPPRTGLNHLWGEDEVTPSGAVPDALLRRVRARQPSMADTVPWRGTSGSPWRRPLSKPDIDGRRGHQGGSCWITALSRLRGCRGPCSGASGCAGGSPSLYRSSGQNGKSRLRLDSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NS32</accession>
    <name>A0A151NS32_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0018641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NS32"/>
    <dbReference type="STRING" id="8496.A0A151NS32"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="498"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO39553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="783" mass="89186" checksum="C18E8855DAA0B764" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSW1</accession>
    <name>A0A151NSW1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0004465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002142">
        <property type="protein sequence ID" value="KYO39961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSW1"/>
    <dbReference type="STRING" id="8496.A0A151NSW1"/>
    <dbReference type="KEGG" id="amj:109282928"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000004">
        <property type="entry name" value="Integrin subunit alpha 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF26">
        <property type="entry name" value="INTEGRIN ALPHA-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586354" description="VWFA domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="1">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="165"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO39961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="270" mass="30133" checksum="414AEA3F0283013E" modified="2016-06-08" version="1">MVAARGLRVPCVLLLIPGLCVSFNIDVKRPQIFHGPSEAQFGYKVLQHEAGGQKWLLVGAPWEGTADDRRGDVYKCAMGSRNRSCSQVHLGDTALRNVSKQIKNMHFGMTLVDNKGEGFVACAPLWSQECGTSMFSTGICTKVDSDFRPTKTIAPTAQRCSTYMDIVIVLDGSNSIYPWYEVQNFLSNILSKFFIDPEQIQVGVLQYGEKAVHEWSLHDYQTAEEVVEAAKNISRQEGRETRTAFAIHTAWCVRGQRYRRGDPSHGRAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTT8</accession>
    <name>A0A151NTT8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin-7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane 4 superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TSPAN7</name>
        <name evidence="11" type="ORF">Y1Q_0000024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in cell proliferation and cell motility.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002066">
        <property type="protein sequence ID" value="KYO40174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTT8"/>
    <dbReference type="STRING" id="8496.A0A151NTT8"/>
    <dbReference type="eggNOG" id="KOG3882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03161">
        <property type="entry name" value="TM4SF2_6_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000003">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048232">
        <property type="entry name" value="TSN6/7_LEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF257">
        <property type="entry name" value="TETRASPANIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO40174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="356" mass="39310" checksum="5578557D5DF18EAA" modified="2016-06-08" version="1">MASRRMETKPVITCLKTLLIIYSFVFWITGVILLAVGVWGKLTLGTYISLIAENSTNAPYVLIGTGTTIIVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTEAIQNYNVNDERSHAVDDVQQSLSCCGIQNYTNWSSSPYFFEHGIPPSCCMNSSDCNPQDLRNMTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLSRFITANHQWDSTKDLSCPCSQRGILRKTCHVAADFVTQPGRLQGEQGQQIGKQFASSSLGARRGREARHPILPWEGDYDALCIQYDSIHTARFFGPCQTPLQWSSAVSKEPTAEPGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUC3</accession>
    <name>A0A151NUC3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Attractin-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Y1Q_0009562</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May play a role in melanocortin signaling pathways that regulate energy homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with MC4R.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUC3"/>
    <dbReference type="STRING" id="8496.A0A151NUC3"/>
    <dbReference type="eggNOG" id="KOG1388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03597">
        <property type="entry name" value="CLECT_attractin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000860">
        <property type="entry name" value="Attractin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000079">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000022">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000036">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000008">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000013">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034011">
        <property type="entry name" value="Attractin-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056732">
        <property type="entry name" value="GBD_ATRN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF4">
        <property type="entry name" value="ATTRACTIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12 17" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1214"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="19">
        <location>
            <begin position="77"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="739"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="21">
        <location>
            <begin position="998"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1027"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO40532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1255" mass="139747" checksum="E13E222C881B5062" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NV28</accession>
    <name>A0A151NV28_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Attractin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NV28"/>
    <dbReference type="STRING" id="8496.A0A151NV28"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11079" checksum="B3D315865DA14689" modified="2016-06-08" version="1">MASRPFASVDVALEVGAEQTDFLRGPLEGAPKPIAIEPCSGNKAAVLTVFLCLPRGSSGVPPPGQSGLAIASALIDISQQKPADCKDKSSGVRNRKHHLSTRQGTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVH5</accession>
    <name>A0A151NVH5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="3">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PFAS</name>
        <name evidence="15" type="ORF">Y1Q_0011385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03001810">
        <property type="protein sequence ID" value="KYO40912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVH5"/>
    <dbReference type="STRING" id="8496.A0A151NVH5"/>
    <dbReference type="eggNOG" id="KOG1907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000007">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000028">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like C-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="14">
        <location>
            <begin position="228"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="13">
        <location>
            <begin position="413"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO40912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="895" mass="94816" checksum="21FD478E124165A4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX83</accession>
    <name>A0A151NX83_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="32">NAD-dependent protein deacylase sirtuin-6</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="34">NAD-dependent protein deacetylase sirtuin-6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="33">Protein mono-ADP-ribosyltransferase sirtuin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="38" type="primary">SIRT6</name>
        <name evidence="38" type="ORF">Y1Q_0011901</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="38 39" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="38">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19149"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:15087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142554"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:19150"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-lysyl-[protein] + NAD(+) = N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142515"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:58221"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:43637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="31">Homodimer; binds to nucleosomes and DNA ends as a homodimer. Interacts with RELA; interferes with RELA binding to target DNA. Interacts with SMARCA5; promoting recruitment of SMARCA5/SNF2H to double-strand breaks (DSBs) sites. Interacts with the mTORC2 complex; preventing the ability of SIRT6 to deacetylate FOXO1. Interacts with the CLOCK-BMAL1 complex; recruited by the CLOCK-BMAL1 complex to regulate expression of clock-controlled genes. Interacts with CSNK2A2; preventing CSNK2A2 localization to the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="38">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX83"/>
    <dbReference type="STRING" id="8496.A0A151NX83"/>
    <dbReference type="GeneID" id="102558981"/>
    <dbReference type="KEGG" id="amj:102558981"/>
    <dbReference type="CTD" id="51548"/>
    <dbReference type="eggNOG" id="KOG1905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140765">
        <property type="term" value="F:histone H3K56 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01410">
        <property type="entry name" value="SIRT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.200:FF:000001">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000029">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0007">Acetylation</keyword>
    <keyword evidence="24" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 35" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="39" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="19" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="15 35" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="37">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="35">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="35">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00050163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00050216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00051286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00066285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00071352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00076455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00083163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EMBL" id="KYO41189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="357" mass="38957" checksum="3D8BC04E63AD87AF" modified="2016-06-08" version="1">MSVNYAAGLSPYSDKGKCGLPEIFDPPEELERKVHELADLIRSSSNVVFHTGAGISTAVGIPDFRGPNGVWTMEEKGLSPKFDTTFENARPSKTHMALLELQRVGILKFLVSQNVDGLHVRSGFPRDKLSELHGNMFVEECVKCGKQYVRDTVVGSMGLKSTGRLCNVTKARGLRACRGKLIDTILDWEDSLPGRDLSLADEACRKADLSITLGTSLQIKPSGNLPLITKKRGGKLVIVNLQATKHDRQADLRIHGYVDEVMMKLMKHLGLEIPEWRGPVVVERAELVKPDEPLKPDPDALCPAKAESSSHHNGIMEGVSGTCPGLGLVPKSHCDSVKQECPSPVAAKRRKAESLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX94</accession>
    <name>A0A151NX94_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transmembrane protein FAM155A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FAM155A</name>
        <name evidence="1" type="ORF">Y1Q_0006145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX94"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO41290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10782" checksum="94CBA49E13EAB1D3" modified="2016-06-08" version="1">MHHCNNNRLSTKPGSVPSILKSHSFTAATEFLASNTVWRFRQGVHLYYQTMMMSSMEDYQVSSVQGSMKTIQPMQNQNAVMSDGDYYQITNPKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZR9</accession>
    <name>A0A151NZR9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0001103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001512">
        <property type="protein sequence ID" value="KYO41915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZR9"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="146"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO41915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="559" mass="62558" checksum="8BAD1F1144911B7C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1X1</accession>
    <name>A0A151P1X1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trehalase</fullName>
            <ecNumber evidence="8">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">Alpha,alpha-trehalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Vacuolar protein sorting-associated protein 11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">TREH</name>
        <name evidence="35" type="ORF">Y1Q_0008109</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Late endosome membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Lysosome membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03001222">
        <property type="protein sequence ID" value="KYO43096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P1X1"/>
    <dbReference type="eggNOG" id="KOG2114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000164">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000570">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000258">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23266">
        <property type="entry name" value="VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0007">Acetylation</keyword>
    <keyword evidence="22" id="KW-0072">Autophagy</keyword>
    <keyword evidence="23 32" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="27" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-0967">Endosome</keyword>
    <keyword evidence="26" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="25" id="KW-0458">Lysosome</keyword>
    <keyword evidence="24" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0488">Methylation</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-0653">Protein transport</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="33" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <keyword evidence="19" id="KW-0862">Zinc</keyword>
    <keyword evidence="17 30" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="33">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586587" description="Trehalase" evidence="33">
        <location>
            <begin position="26"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="31">
        <location>
            <begin position="911"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="31">
        <location>
            <begin position="1071"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="34">
        <location>
            <begin position="1321"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="32">
        <location>
            <begin position="1271"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00030473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00073716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KYO43096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1440" mass="164893" checksum="B842D829EEDF483A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3R7</accession>
    <name>A0A151P3R7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger and SCAN domain-containing protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZSCAN30</name>
        <name evidence="13" type="ORF">Y1Q_0010476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001152">
        <property type="protein sequence ID" value="KYO43395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3R7"/>
    <dbReference type="STRING" id="8496.A0A151P3R7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001997">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000424">
        <property type="entry name" value="Zinc finger protein 140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001228">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001119">
        <property type="entry name" value="zinc finger protein 408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000030">
        <property type="entry name" value="Zinc finger protein 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001730">
        <property type="entry name" value="zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001630">
        <property type="entry name" value="Zinc finger protein 888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF57">
        <property type="entry name" value="ZINC FINGER PROTEIN 154-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO43395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="350" mass="39799" checksum="23AF7F40EA56F057" modified="2016-06-08" version="1">MGLTEYSECAKSFPRSSNLTRHQLIHTGERPHQCSECGKRFNLSSYLTKHQLIHTGEKPHQCLECGKSFRQLSDLARHQLIHTQEKPHRCPECGKSFTQFSNLTQHRLTHTVEKPHQCSECGKRFSVSSYLTMHQRIHTGERPHQCLECGKSFARSSNLTQHRLIHMVEKPHRCLECGKSFNLSSDMTKHQLVHMQEKPHQCSECGKSFTRLSNLTQHRLIHTGEKPHQCLECGKSFTRSSNLTKHQRIHPREKPHQCSQCGKSFTQFRHLAWHQLSHRRKSTCVLTVCKDLPALLKTGPAPVHPLPGAFIILPAVQGLGTSTCLGPTSVCIQANMPVDCHNSSTFVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4Z3</accession>
    <name>A0A151P4Z3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000978">
        <property type="protein sequence ID" value="KYO44040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4Z3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO44040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="11232" checksum="4E80E3B93C6FB9F0" modified="2016-06-08" version="1">MREAMQEVKAQLGSWYQEEARKEIFQARAPWVEEGEEQSAYFSKLKKSKEEVMMCLNNEEGVEHWLKDGMLATAAAFYWDLYTEKSVDPEGMQLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5H5</accession>
    <name>A0A151P5H5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline-rich protein 15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PRR15L</name>
        <name evidence="3" type="ORF">Y1Q_0012091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRR15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014459069.2">
        <property type="nucleotide sequence ID" value="XM_014603583.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5H5"/>
    <dbReference type="STRING" id="8496.A0A151P5H5"/>
    <dbReference type="GeneID" id="102565246"/>
    <dbReference type="CTD" id="79170"/>
    <dbReference type="eggNOG" id="ENOG502S3QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9937618at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028237">
        <property type="entry name" value="PRR15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14581">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14581:SF5">
        <property type="entry name" value="PROLINE-RICH PROTEIN 15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15321">
        <property type="entry name" value="ATAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO44321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="158" mass="17713" checksum="5BE62E4C7F125D26" modified="2016-06-08" version="1">MSPHPPPSSPLPETPSLRLKSLPPARGAADLWDPTLPFLTGRNKFHLLQPGGANMAENNYSWWKLTFLRKKKSAPKVLYESPDIYANENQQEGTRAEAGGGSETNCEFNARLEKIVDKNTKGKHVKVSHSGRFKEKKKVRSTLAENPNLYTDGDREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6F1</accession>
    <name>A0A151P6F1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Suppressor of cytokine signaling 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SOCS7</name>
        <name evidence="20" type="ORF">Y1Q_0012077</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Substrate-recognition component of the ECS(SOCS7) complex, composed of SOCS7, CUL5, ELOB, ELOC and RNF7/RBX2. Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6. Interacts with phosphorylated IRS4 and PIK3R1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6F1"/>
    <dbReference type="STRING" id="8496.A0A151P6F1"/>
    <dbReference type="eggNOG" id="KOG4566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151P6F1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd10388">
        <property type="entry name" value="SH2_SOCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03741">
        <property type="entry name" value="SOCS_SOCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000029">
        <property type="entry name" value="Suppressor of cytokine signaling 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035866">
        <property type="entry name" value="SOCS7_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037346">
        <property type="entry name" value="SOCS7_SOCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF5">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="8" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="201"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="19">
        <location>
            <begin position="305"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO44305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="382" mass="42725" checksum="FB07F97251808840" modified="2016-06-08" version="1">MGAGVGPRRGSLKIRLSRLFRTKSCSDPAAAAAADRRCSGELPASAGSLTDVSSARGREQDAGRKPRLTRTQSAFSPAAFSPLFTGETVSLVDVDISQRGLTSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVGPMGSSLQSFPLPPPPPPHAPDAFPRIVPLRPTEAVPSQPSQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPELPLPKPLISYIRKFYYYDPQEEVYLSLKEAQLISKQKQETESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P966</accession>
    <name>A0A151P966_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Girdin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CCDC88A</name>
        <name evidence="9" type="ORF">Y1Q_0015164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCDC88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P966"/>
    <dbReference type="eggNOG" id="KOG4643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254988at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000035">
        <property type="entry name" value="girdin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF31">
        <property type="entry name" value="PROTEIN DAPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1419"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1557"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1745"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1825"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1888"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1984"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="457"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="605"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="978"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1139"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1419"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1440"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1561"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1572"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1798"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1865"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1888"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1899"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1998"/>
            <end position="2008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO45510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2025" mass="232748" checksum="5C6CCFD79DCD0100" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9F7</accession>
    <name>A0A151P9F7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">E3 ubiquitin-protein ligase RNF4</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">RING finger protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">RNF4</name>
        <name evidence="26" type="ORF">Y1Q_0021343</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer (via RING-type zinc finger domain). Interacts with GSC2. Interacts with AR/the androgen receptor and TBP. Interacts with TCF20. Interacts with PATZ1. Interacts with TRPS1; negatively regulates TRPS1 transcriptional repressor activity. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6). Interacts with PRDM1/Blimp-1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059577500.1">
        <property type="nucleotide sequence ID" value="XM_059721517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9F7"/>
    <dbReference type="STRING" id="8496.A0A151P9F7"/>
    <dbReference type="GeneID" id="102570520"/>
    <dbReference type="KEGG" id="amj:102570520"/>
    <dbReference type="CTD" id="6047"/>
    <dbReference type="eggNOG" id="KOG0320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P9F7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16533">
        <property type="entry name" value="RING-HC_RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000173">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043295">
        <property type="entry name" value="RING-HC_RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="25">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="81"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00059625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00078875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO45662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="194" mass="21524" checksum="B12D67510266B3FD" modified="2016-06-08" version="1">MSTTQRKRRGGEIGSRQTQKRSRLAASATEMASEAEPIELEESAGEEVVDLTCESSEPVVVDLTRNDSVVIVEENQQPRRNLGLRSQRQSDSCVLSSDEEDESRDNDTCERNKVYGGSGTLEDETTDSRPSGTISCPICMDGYSEIIQSGRLIVATKCGHVFCSQCLRDSLRNANSCPTCRKKLSHRQYHPIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PA82</accession>
    <name>A0A151PA82_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PA82"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="134" mass="13850" checksum="9D2A7878D39F2EEE" modified="2016-06-08" version="1">MSKGKRGKLGPSDEEKVEDVADDETGDSWSIAPFLYQLGKGGVTEDAGIMDTALPASEDVYGVAPMVHDALQDDREVALMIDECSSALVLAEDGDVCAIHGSHAFGGAHKAETTGGMAPGLTLKGSQSHFTGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAU9</accession>
    <name>A0A151PAU9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Palladin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PALLD</name>
        <name evidence="23" type="ORF">Y1Q_0021759</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="19">Interacts with EPS8. Interacts with LASP1. Interacts with VASP. Interacts with ACTN. Interacts with SORBS2. Interacts with PFN1. Interacts with LPP. Interacts with SPIN90. Interacts with SRC. Interacts with EZR. Interacts with RAI14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">Z line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the myotilin/palladin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAU9"/>
    <dbReference type="STRING" id="8496.A0A151PAU9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05892">
        <property type="entry name" value="IgI_Myotilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000256">
        <property type="entry name" value="myopalladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001560">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000761">
        <property type="entry name" value="palladin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001108">
        <property type="entry name" value="palladin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF10">
        <property type="entry name" value="PALLADIN, CYTOSKELETAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="160"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="565"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="699"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="797"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="327"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00065150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO46221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="947" mass="104666" checksum="FACBC78E09290300" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBQ2</accession>
    <name>A0A151PBQ2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Synaptic vesicle membrane VAT-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">VAT1</name>
        <name evidence="6" type="ORF">Y1Q_0018279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PBQ2"/>
    <dbReference type="eggNOG" id="KOG1197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010637">
        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08275">
        <property type="entry name" value="MDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052100">
        <property type="entry name" value="SV-ATPase_mito-regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44054:SF1">
        <property type="entry name" value="SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44054">
        <property type="entry name" value="SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="59"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO46468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="400" mass="43235" checksum="64BE59FC911A66E4" modified="2016-06-08" version="1">MSGEEAAAAPPAAAAEQQXXXXPEQPQPEQPPQEGSGDAPAPTPAPEPQHRALVLTGFGGYEKVKVQARKGAPSPRPGELALRVSACGLNFADLLARQGLYDRLPPPPVCPGMECAGTVLALGDGVSDRQVGDKVMVLARAGLWQEVVTVPANQTFLMPEGMSFEEAAAFLVNYITAYMILFDFGNLRPNQSVLIHMAAGGVGTAAIQLCKTVENVTIFGTASASKHDFLRESGVTHPIDYRTMDYVEEVRKISPKGVDIVLDPLGGSDTSKAFNLLKPMGKLITYGVANLLTGQRKNLMAMAKTWWNQFSINALQLLHHNKAVCGYHLGYMDEESDLIAGVVAKLVSLYNQGKIKPKIDSVWPFEQVADAMRQMQEKKNIGKVVLVPEALKEESKKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCC2</accession>
    <name>A0A151PCC2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Keratin, type I cytoskeletal 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0018447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCC2"/>
    <dbReference type="STRING" id="8496.A0A151PCC2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF379">
        <property type="entry name" value="IF ROD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="4">
        <location>
            <begin position="90"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="186"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO46702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="334" mass="36637" checksum="42A1025A98EC10EB" modified="2016-06-08" version="1">MSGGSFGPSGGGICGGYGGGAGGFGGGGAGFGGGYGGGPGPCGFGGSGGFSGGGFSGSGGFGGGGFSGGGGGFSGGSFGGDDTGLLSNNEKMTMQNLNERLASYLDKVRRLEEENANLEQLIREWYQKQGPQGGRDYSQYYKTIEDLQNQIISATVDLNKVLLDVDNTRMTADDFRMNVEVNAAPGTNLTEKLNEMRGEYERLIENNRREVESWFEAKMEEVNQQVHSSSQEMESSNQQVSELRREYQTLEIELQSLLSMLQSFQSNLEDTERRYNMQLQQIQAMIIPVEEELANIRCEMESQNEEYKMLLVWQQRWRKPWVCKKILTRDTNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCR5</accession>
    <name>A0A151PCR5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCR5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="8591" checksum="C6A41E01C710CA25" modified="2016-06-08" version="1">MSWMKPSNVIDDYARPLCMHNKKLSTCSLAQAHFPSGACENLCDGVAVAKTKSRTSMEQLCLDTKMESLSLVHFIGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCW0</accession>
    <name>A0A151PCW0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCW0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="189" mass="21679" checksum="364DFB04C521205C" modified="2016-06-08" version="1">MYQATFMDMITQLDPDIVHKDITMHLSFTLEKRVAITIKNVTTPNSYHYIVNQFRVGKTTAGEATQEVCLVIQDVLDNHIICFINPQEEQYFGPNISLERVSQTQRDEFCHYSQGRTSQYVVLLLQEMVPQELLKSWKGDTCFGGGPRKPGLPLNLKIHLMCYPWLCYDVLTHPDEFTIANNISALPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PD60</accession>
    <name>A0A151PD60_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein-cysteine N-palmitoyltransferase HHAT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HHATL</name>
        <name evidence="8" type="ORF">Y1Q_0014582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO47047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006278276.2">
        <property type="nucleotide sequence ID" value="XM_006278214.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PD60"/>
    <dbReference type="STRING" id="8496.A0A151PD60"/>
    <dbReference type="GeneID" id="102559758"/>
    <dbReference type="KEGG" id="amj:102559758"/>
    <dbReference type="CTD" id="57467"/>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF19">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE HHAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO47047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="503" mass="57556" checksum="59DE4E8690464D7C" modified="2016-06-08" version="1">MGIKAALPSYELGFYALVLTCAIVYSSSDIFEASRDNMNRKAFREAIKPGWHYFGRKMDAADFEWAMWFSSFRNFILFALSGHVLFAKVCSMIVPQHRSVVYMLYGMLAVLSTMGTSYLMIILTHCLVLYSVSLAKQKWLCFAAGLCSLASFKLEPFSTWQNGFVTGTFDLQDVLFYGGSGFTIMRCMSLALENCERQEGIYSIVDLLKYNFYLPFFFFGPVMTFDQFHAQVATSELRRKENEMWSIRVQALVHLGVIAAVAVFFHFFYILTLPSDLKFVNRLSDWALAGLAYSNLVYDWVKAAVMFGVINTVSRLDHLDPPKPPKCITMLYVFAETHFDRGINDWLCKYVYDHIGEDHNNIVKELLATISTFAVTTLWLGPCEIVYIWSVCNCFGLNFELWVQKFFQMAPFASVEASMSEAMSRRIRGIFGAANFWAIILYNVLALNSLDFALIVAKRIILMGFPMSTVSIWFITYCGVQLIKERERLQAIEEEKADKEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDA9</accession>
    <name>A0A151PDA9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">La-related protein 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LARP4B</name>
        <name evidence="6" type="ORF">Y1Q_0014488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259300.1">
        <property type="nucleotide sequence ID" value="XM_006259238.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDA9"/>
    <dbReference type="STRING" id="8496.A0A151PDA9"/>
    <dbReference type="GeneID" id="102560524"/>
    <dbReference type="KEGG" id="amj:102560524"/>
    <dbReference type="CTD" id="23185"/>
    <dbReference type="eggNOG" id="KOG2591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10046764at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PDA9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08031">
        <property type="entry name" value="LARP_4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12706">
        <property type="entry name" value="RRM_LARP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034900">
        <property type="entry name" value="LARP4B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF43">
        <property type="entry name" value="LA-RELATED PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26088">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="138"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO46914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="725" mass="80666" checksum="22387546F14FD0BE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEN6</accession>
    <name>A0A151PEN6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Receptor-type tyrosine-protein phosphatase zeta</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">PTPRZ1</name>
        <name evidence="27" type="ORF">Y1Q_0019667</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PEN6"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03122">
        <property type="entry name" value="alpha_CARP_receptor_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17669">
        <property type="entry name" value="R-PTP-Z-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000016">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase gamma isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000313">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000004">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase zeta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000013">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase zeta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041887">
        <property type="entry name" value="Alpha_CARP_receptor-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF461">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="27" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586963" description="Receptor-type tyrosine-protein phosphatase zeta" evidence="22">
        <location>
            <begin position="20"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="26">
        <location>
            <begin position="36"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="314"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="23">
        <location>
            <begin position="669"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="24">
        <location>
            <begin position="914"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="23">
        <location>
            <begin position="1003"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="24">
        <location>
            <begin position="1179"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="408"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1270"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1270"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO47546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1295" mass="146558" checksum="D133EA2B80A1DE69" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PH81</accession>
    <name>A0A151PH81_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calbindin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CALB1</name>
        <name evidence="10" type="ORF">Y1Q_0024680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the calbindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000227">
        <property type="protein sequence ID" value="KYO48312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266752.1">
        <property type="nucleotide sequence ID" value="XM_006266690.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PH81"/>
    <dbReference type="STRING" id="8496.A0A151PH81"/>
    <dbReference type="GeneID" id="102571015"/>
    <dbReference type="KEGG" id="amj:102571015"/>
    <dbReference type="CTD" id="793"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428774at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PH81"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005499">
        <property type="term" value="F:vitamin D binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900271">
        <property type="term" value="P:regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16176">
        <property type="entry name" value="EFh_HEF_CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000108">
        <property type="entry name" value="Calbindin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000054">
        <property type="entry name" value="Calbindin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029634">
        <property type="entry name" value="Calbindin_six-EFh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF14">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0848">Vitamin D</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO48312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="262" mass="30070" checksum="E11E4F65A7697B99" modified="2016-06-08" version="1">MAAEAHLQAAEISASQCFEIWRHYDSDGNGYMDGKELQTFIQELQQARKKAGLELTSEMKAFVDQYGGNVDGKIGIVELAQILPTEENFLLFFRCQQLKSSEDFMQTWRKYDTDHSGFIDTEELKNFLKDLLQKANKQIDDAKLTEYTEIMLRMFDANNDGKLELTEMARLLPVQENFLIKFQGVKMSGKEFNKAFELYDQDGSGFIDENELDALLKDLCEKNKKDLDINNISTYKKNIMALSDGGKLYRTELALILCAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHY7</accession>
    <name>A0A151PHY7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription factor IIH subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GTF2H2</name>
        <name evidence="15" type="ORF">Y1Q_0004031</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270035.1">
        <property type="nucleotide sequence ID" value="XM_006269973.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014450899.1">
        <property type="nucleotide sequence ID" value="XM_014595413.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019338327.1">
        <property type="nucleotide sequence ID" value="XM_019482782.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019338338.1">
        <property type="nucleotide sequence ID" value="XM_019482793.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019338342.1">
        <property type="nucleotide sequence ID" value="XM_019482797.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHY7"/>
    <dbReference type="STRING" id="8496.A0A151PHY7"/>
    <dbReference type="GeneID" id="102560483"/>
    <dbReference type="KEGG" id="amj:102560483"/>
    <dbReference type="CTD" id="2966"/>
    <dbReference type="eggNOG" id="KOG2807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PHY7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000282">
        <property type="entry name" value="General transcription factor IIH subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="60"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO48628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="395" mass="44668" checksum="9E49BAACB115E942" modified="2016-06-08" version="1">MDDEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKKLFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITALKKAIDMACHGEPSLYNSLNLAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYELIKCLKAVKIRVSIIGLSAEVRVCTVLARETGGTYHVILDESHYKELLMHHVTPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMVQLENNSDPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEVPLEEYQGERYCHGCQGEMKDQHVYICKVCQSAFCVDCDLFVHDSLHCCPGCIHKHPAPLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PI42</accession>
    <name>A0A151PI42_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PJA2</name>
        <name evidence="12" type="ORF">Y1Q_0004151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PI42"/>
    <dbReference type="STRING" id="8496.A0A151PI42"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16465">
        <property type="entry name" value="RING-H2_PJA1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000152">
        <property type="entry name" value="E3 ubiquitin-protein ligase Praja-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="697"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO48787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="770" mass="85175" checksum="71588E94D4B14ED3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIJ5</accession>
    <name>A0A151PIJ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FAM228B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM228</name>
        <name evidence="2" type="ORF">Y1Q_0020221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM228 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000178">
        <property type="protein sequence ID" value="KYO48870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIJ5"/>
    <dbReference type="STRING" id="8496.A0A151PIJ5"/>
    <dbReference type="eggNOG" id="ENOG502S14E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040046">
        <property type="entry name" value="FAM228"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28584">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 228 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28584:SF1">
        <property type="entry name" value="PROTEIN FAM228B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="418" mass="49501" checksum="08E79C3A6C418775" modified="2016-06-08" version="1">MVINLFLPAIGVDASGLEGDLEYRFLWPPFERWPTESWEKRIWRGRHLVFYTGLCQSESRESLLARRRSSDDFWLLRSHSSEAENEQDVQEIPSSVYEKDQKLSTCSRKKSSHVWQDPWTPLQKAYSPLDSGKKKPTRDWLTQKHVSLVKAVSSESKGITDSAKTILDEEDYFVKEVDRYLNHNDFLNLRKKEIQYKKWLERVSEPLLHKIEDKVDSQSSEEIEERKRNQLALYLNYCNKKGNVVFEDYDASEYDPFFLKTHTNYWKVSTPPFKDPLLKEVQGKSLEKGIIQQCETGRIYSAKEMNELHKAKLPPLPLGRQRWDAVEWLKIAPGYIDSEVHQRKRRRMTRNQNKGTLDFKAWSDTACLPILWKEGMHIHQVKTDFCLMQQKLSSYHHGNFKMYEDLFEMYEVHKQRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJA2</accession>
    <name>A0A151PJA2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000005">
        <property type="protein sequence ID" value="KYO49186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJA2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO49186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9451" checksum="BD1317C1EF3B497E" modified="2016-06-08" version="1">MSPVNMFREGRAQKPGFRVGNWRGIEWRHLQYGLQGEAPSTLASGDAKGVDTVGTEFPGKNSCRRYPGRHQSTLRGEMKAQGKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYD0</accession>
    <name>A0A151LYD0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007029">
        <property type="protein sequence ID" value="KYO17248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYD0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO17248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10391" checksum="C854133DED697612" modified="2016-06-08" version="1">MVDMYGSFSLQNTSKRREQCLLMITGLQWKRTLKHQNWPENPGKRPLCPSGWQASLLLWAQGFVVGAITLGVIYSMYKDFVKSPLKTGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYZ7</accession>
    <name>A0A151LYZ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DDX47</name>
        <name evidence="15" type="ORF">Y1Q_0020078</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYZ7"/>
    <dbReference type="STRING" id="8496.A0A151LYZ7"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000626">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="162"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO17473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="380" mass="42872" checksum="E1D863D5F34BF259" modified="2016-06-08" version="1">MAAGEEQGSVEVAPETRSFKELVVMSSDWQKQISEQFEALGSSIGVQSAVIVGGIDMMSQSLALAKKPHVVIATPGRLIDHLENTKGFNLRALKYLVMDEADRILNMDFETEVDKILKVIPRDRKTFLFSATMTKKVQKLQRAALKDPVKCAVSSKYQTVEKLQQYYIFIPSKFKDSYLVYILNELAGNSFMIFCSTCNNTQRTALVLRNLGFTAIPLHGQMSQNKRLGSLNKFKAKTRSILLATDVASRGLDIPHVDVVINFDIPTHSKDYIHRVGRTARAGRSGKSITFVTQYDVELFQRIEHLIGKKLPAFPTQEEEVMMLTERVAEAQRFARMELREQGEKKKRSRDEVNDNDDTEAATGVRNKVAGGKKKKRKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZH8</accession>
    <name>A0A151LZH8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosylphosphatidylinositol anchor attachment 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006892">
        <property type="protein sequence ID" value="KYO17640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZH8"/>
    <dbReference type="STRING" id="8496.A0A151LZH8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO17640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="126" mass="14231" checksum="6A1097890432726C" modified="2016-06-08" version="1">MTLKLLSLLYLAMQLGCIALINFSLGFLLAVTMVPVAAIVQPVGPKYVYAVLLVLVTPAATLLLSIFLYQELIEYPVSLLECWQLFLQAVAEGLLDHYLYGSIVFPFVAIFVYPCWLLLWNVLFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZJ5</accession>
    <name>A0A151LZJ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC12</name>
        <name evidence="3" type="ORF">Y1Q_0014277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006878">
        <property type="protein sequence ID" value="KYO17689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006277376.3">
        <property type="nucleotide sequence ID" value="XM_006277314.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZJ5"/>
    <dbReference type="STRING" id="8496.A0A151LZJ5"/>
    <dbReference type="GeneID" id="102568900"/>
    <dbReference type="KEGG" id="amj:102568900"/>
    <dbReference type="CTD" id="151903"/>
    <dbReference type="eggNOG" id="KOG3407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="PhylomeDB" id="A0A151LZJ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO17689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="177" mass="19934" checksum="B446F4FCA9A73980" modified="2016-06-08" version="1">MAAPVAGAGRDPASEAAPGVGRLQEEALRRKERLRALRDRTLKTKDSGEPASKQLREDDEESAVKHMELRLRNYNPEDEELKKRKVPQAKPASVEEKVKDQLEAAKPEPIIEEVDLANLAPRKPDWDLKRDVAKKLEKLEKRTQRAIAELIRERLRGQEDDLASAVGSAKQEESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M185</accession>
    <name>A0A151M185_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0002549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006846">
        <property type="protein sequence ID" value="KYO18275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M185"/>
    <dbReference type="KEGG" id="amj:109281320"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="4">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO18275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="11484" checksum="A85D62CCEDEB89B3" modified="2016-06-08" version="1">MAGEMGMEEVFGSLHAIKQEIEQLLHPDGTHGSSACTCQDLQLFGPGLPEGEYWIDLNQGCAHIAFKVFCNFTAGGETLIFPSKESETVPMSAWEDEKPQTWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M250</accession>
    <name>A0A151M250_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M250"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="88" mass="9970" checksum="769AF5C370E08FD7" modified="2016-06-08" version="1">MRIAMSLCRWESKQAPDKKRKGRLCHLFQVASSSDEAKQQGRAGVKCTWEGIHRVVLSKSRQILKEAASFPDIMKHTSAKTFPGNLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4B9</accession>
    <name>A0A151M4B9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor BTF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BTF3L4</name>
        <name evidence="5" type="ORF">Y1Q_0003498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
        <property type="protein sequence ID" value="KYO19357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006262294.1">
        <property type="nucleotide sequence ID" value="XM_006262232.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4B9"/>
    <dbReference type="STRING" id="8496.A0A151M4B9"/>
    <dbReference type="GeneID" id="102573009"/>
    <dbReference type="KEGG" id="amj:102573009"/>
    <dbReference type="CTD" id="91408"/>
    <dbReference type="eggNOG" id="KOG2240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M4B9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO19357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="158" mass="17229" checksum="8C4AD36963886722" modified="2016-06-08" version="1">MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRPVLDSKAPKSEDIDEEDDDVPDLVENFDEASKNEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M599</accession>
    <name>A0A151M599_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PSMB4</name>
        <name evidence="5" type="ORF">Y1Q_0012346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006582">
        <property type="protein sequence ID" value="KYO19693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M599"/>
    <dbReference type="STRING" id="8496.A0A151M599"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO19693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="281" mass="30873" checksum="FF02FB601D2B5DAB" modified="2016-06-08" version="1">MRVVELGRAAVTKMEAAGMVPVPWAGGRAPGQLCALRAGPGLGLQLDLDLELQAGGGEPLTRTLSPMVTGTSVLGVRFDGGVVVAADTLGSYGSLARFRNISRIMKVNDNTVLGASGDYADFQYLKQVIDQMVIDEELLGDGHNYSPKAIHSWLTRAMYSRRCKMNPLWNTVVIGGFYNGESFLGYVDMLGVAYEAPTLATGYGAYLAQPLMREALEKKPILTKEEAQDLIERCMKILYYRDARSFNRFQIAVVTEKGVEVEEPRSVETNWDIAHLIRGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6K6</accession>
    <name>A0A151M6K6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0010682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6K6"/>
    <dbReference type="STRING" id="8496.A0A151M6K6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF206">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="94"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO20101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="225" mass="25005" checksum="36E42C9CE0C4276D" modified="2016-06-08" version="1">MLEPHIARQDTSMCRTIPPDRRVAMAIIKLASPSSLHCIMNQFGVAACMARLASCDVCHLVKEIASKKIINLANLQQVIDGFNEKGLLNCVKVLDSTHIPVLCPVGRGRAFTNRKGYAFMILQAMVDHWGWFINICIGWTTSGHDACMFRNSPLPVYEEKGHYTPSVEETVICSVSVPPVILVAAAYPIKPWFMKRYGENVTDPQKLVFNNLLSSCKMAMECAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M899</accession>
    <name>A0A151M899_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M899"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="8063" checksum="C298E62AE28007F2" modified="2016-06-08" version="1">MIKKRAEVFCIEKTGKRSLRQKQPNFIPEKPQRGQNKTGVSRYCRKLIFQINKRESDERILKELKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8N5</accession>
    <name>A0A151M8N5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PERQ amino acid-rich with GYF domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GIGYF1</name>
        <name evidence="5" type="ORF">Y1Q_0000221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the GIGYF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006352">
        <property type="protein sequence ID" value="KYO20876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8N5"/>
    <dbReference type="STRING" id="8496.A0A151M8N5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048009">
        <property type="term" value="P:insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.40:FF:000001">
        <property type="entry name" value="GRB10-interacting GYF protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF37">
        <property type="entry name" value="GRB10-INTERACTING GYF PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="4">
        <location>
            <begin position="486"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="663"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO20876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="719" mass="77860" checksum="FE943C5F36F9F350" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8X5</accession>
    <name>A0A151M8X5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO20962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8X5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="11195" checksum="2D26B8C2502C78E1" modified="2016-06-08" version="1">MLRCRLRQLGKFKISFELRSSGSSRGQVEIHTLKTTLPKTGKRERKRINRDNWCLRKLITVSPNLPGRDPMKMSGTPVCLEHHLLKDSALYGVSFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9A3</accession>
    <name>A0A151M9A3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FAM169B isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM169B</name>
        <name evidence="2" type="ORF">Y1Q_0001336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9A3"/>
    <dbReference type="STRING" id="8496.A0A151M9A3"/>
    <dbReference type="eggNOG" id="ENOG502S058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029625">
        <property type="entry name" value="FAM169"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22442">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22442:SF4">
        <property type="entry name" value="PROTEIN FAM169BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO21020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="407" mass="45496" checksum="FC56067898CF591C" modified="2016-06-08" version="1">MNSLVVFLETWEKKDSRSFQLSRMLVKHIQSKGQLYPVDIAGGKPEIFQVAAEAYYAKLLQQGSSSPDLFSIPGGEKVKLEASCVRFLPVYRDNTSCKILVLTSPQDKETVLAVYLNQSWWPIEEIVKTADPAREGLIPVQTFGERIVLFVLNYIIFGMLERSSANDAFFVPHSATEHAKILWRNGDAVAFYTFKMKGSLCNDNTSQCYFLPVLDTIFVRRKNRGCGLGMTMLQDFCQSFGTEDALGISCPISGAMYQVCQRFLQAHTEEQERLWEVEAPGDWSQRVNIWLKIRLGPGLPESHHHSSEDKGGCPIAQTCDDEPRQSDAGQMNQGDERVSDGGKESQDAKENADDTATEARPLDLQAIREEDFSPGVPDAQQCKESRKRVSTGDSVVDKAAKQLRVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCE8</accession>
    <name>A0A151MCE8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0000779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046790">
        <property type="term" value="F:virion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000153">
        <property type="entry name" value="MUC5B isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000414">
        <property type="entry name" value="von Willebrand factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF264">
        <property type="entry name" value="MUCIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="144"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="495"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="966"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO22195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1338" mass="149553" checksum="8305A70C53025D83" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCF5</accession>
    <name>A0A151MCF5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inscuteable-like protein isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">INSC</name>
        <name evidence="3" type="ORF">Y1Q_0000692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO22080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCF5"/>
    <dbReference type="STRING" id="8496.A0A151MCF5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009786">
        <property type="term" value="P:regulation of asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21966">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.10">
        <property type="entry name" value="Inscuteable LGN-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045789">
        <property type="entry name" value="Insc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031938">
        <property type="entry name" value="INSC_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038205">
        <property type="entry name" value="INSC_LBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039921">
        <property type="entry name" value="Inscuteable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386">
        <property type="entry name" value="INSCUTEABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386:SF0">
        <property type="entry name" value="PROTEIN INSCUTEABLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19427">
        <property type="entry name" value="Insc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16748">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein inscuteable homologue LGN-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO22080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="553" mass="62417" checksum="F5FAA419968C5EFD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCJ8</accession>
    <name>A0A151MCJ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenoprotein W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SEPW1</name>
        <name evidence="3" type="ORF">Y1Q_0018838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006235">
        <property type="protein sequence ID" value="KYO22245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCJ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO22245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="77" mass="8602" checksum="6E88FB4B69438A3B" modified="2016-06-08" version="1">MEAPRLRVHIVFWTRFMQLREFLEKRFPQKLEITGEPVSIPNAFEVLLPDSGQVLHSKQNGDGAPTPGSVLSTAADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDE5</accession>
    <name>A0A151MDE5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calsequestrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CASQ2</name>
        <name evidence="12" type="ORF">Y1Q_0003001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calsequestrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261536.1">
        <property type="nucleotide sequence ID" value="XM_006261474.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDE5"/>
    <dbReference type="STRING" id="8496.A0A151MDE5"/>
    <dbReference type="GeneID" id="102568527"/>
    <dbReference type="KEGG" id="amj:102568527"/>
    <dbReference type="CTD" id="845"/>
    <dbReference type="eggNOG" id="ENOG502QU4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038131at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033018">
        <property type="term" value="C:sarcoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010881">
        <property type="term" value="P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03074">
        <property type="entry name" value="PDI_b'_Calsequestrin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03066">
        <property type="entry name" value="PDI_b_Calsequestrin_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03065">
        <property type="entry name" value="PDI_b_Calsequestrin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000031">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000033">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000047">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001393">
        <property type="entry name" value="Calsequestrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041860">
        <property type="entry name" value="Calsequestrin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018233">
        <property type="entry name" value="Calsequestrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041858">
        <property type="entry name" value="Calsequestrin_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041859">
        <property type="entry name" value="Calsequestrin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033">
        <property type="entry name" value="CALSEQUESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10033:SF15">
        <property type="entry name" value="CALSEQUESTRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01216">
        <property type="entry name" value="Calsequestrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00312">
        <property type="entry name" value="CALSEQUESTRN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00863">
        <property type="entry name" value="CALSEQUESTRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00864">
        <property type="entry name" value="CALSEQUESTRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585053" description="Calsequestrin" evidence="11">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO22420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="400" mass="46330" checksum="1CC98294962AF46D" modified="2016-06-08" version="1">MKVAFWLVAGLYLLFCCKAEEGLNFPTYDGKDRVIDLNEKNYKQALKKYDMLCLLFHEPTGSDKVSQKQFQMTEMVLELAAQVLEDKGIGFGMVDSKKDAKLAKKLGLVEEGSLYIFKEERLIEFDGELATDVIVEFLLDLLEDPVEIINSKLELQAFDRIEEEIKLIGYFKGEDTEHYKAFEEAAEHFQPYVKFFATFDKGVAKKLGLKLNEVDFYEPFMDEPVHVPDKPYSEEELVEFVNEHKRATLRKLRPEDMFETWEDDLDGIHIVAFAEEDDPDGYEFLEILKQVAKDNTNNPDLSIVWIDPDDFPLLITYWEKTFKIDLFKPQIGVVNVTDADSIWMEIKDDDDLPTAEELEDWIEDVLSGKINTEDDDDVDDDDDDDDDDDDNDDDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ME16</accession>
    <name>A0A151ME16_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell adhesion molecule 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CADM2</name>
        <name evidence="12" type="ORF">Y1Q_0003156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ME16"/>
    <dbReference type="STRING" id="8496.A0A151ME16"/>
    <dbReference type="eggNOG" id="ENOG502QV9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05884">
        <property type="entry name" value="IgI_2_Necl-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07701">
        <property type="entry name" value="IgV_1_Necl-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000013">
        <property type="entry name" value="cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF1">
        <property type="entry name" value="CELL ADHESION MOLECULE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="230"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO22640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="438" mass="47711" checksum="8F4C182F8352724F" modified="2016-06-08" version="1">MDSIINGHVDELDSLAVTKNKAKGSQGQFPLTQNVTVVEGGTANLTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAFLTVLGVPEKPQITGFASPVMEGERMQLTCKTSGSKPAADIRWFKNDKEVKDAKYLKEEDANRKTFTVSSTLDFRVDRNDDGAVVSCRVDHESLNSTPQIAMQVLEIHYTPSVKIISSNSWPEEGQTIILTCESKGKPVPEPVLWTKDGGELPDPERMVVNGRDLSISFLNKTDNGTYRCEATNPIGQNSTEYVLIVHDVSNTLLPITVIPSLTTATVTTTVALTTSTAPSATAISTRDPNALTGQPVPDHALIGGIVAVVVFVTLCSIILLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEN8</accession>
    <name>A0A151MEN8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein ABHD14A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Alpha/beta hydrolase domain-containing protein 14A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ABHD14A</name>
        <name evidence="16" type="ORF">Y1Q_0005483</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Possible role in granule neuron development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AB hydrolase superfamily. ABHD14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO22988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEN8"/>
    <dbReference type="STRING" id="8496.A0A151MEN8"/>
    <dbReference type="eggNOG" id="ENOG502QR0B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000093">
        <property type="entry name" value="protein ABHD14A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197:SF1">
        <property type="entry name" value="PROTEIN ABHD14A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46197">
        <property type="entry name" value="PROTEIN ABHD14B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="15">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO22988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="281" mass="31266" checksum="ABAAEE446FE448CD" modified="2016-06-08" version="1">MELRRVLVWRYCGTERMTMTLIRNRLGLLVLGVLVTFVLYLLLPAIQHERFTAHLDDSKPLAMEERSQQDANTTVLTGTIEGDPPILYREAFLLQKAGTPSPKRLDVIFLHGQAFTSKTWEDLGTLALLSEEGYRPIAIDLPGFGSSPRSDAVSTEQGRVGLLQRVLKELSVHKPVLVSPSMSGRYSIPFLLAHGAELKGFVPIAPVGTKDHSAQQYQEVQTPTLIIYGDRDTGLGTQSLQSLQQIPKHQTAALRDAGHACYLDRPREFHEVLLSFLGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHQ1</accession>
    <name>A0A151MHQ1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0004639</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006155">
        <property type="protein sequence ID" value="KYO24057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHQ1"/>
    <dbReference type="STRING" id="8496.A0A151MHQ1"/>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000105">
        <property type="entry name" value="Protocadherin 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000042">
        <property type="entry name" value="protocadherin-19 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF41">
        <property type="entry name" value="PROTOCADHERIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="215"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="331"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="413"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO24057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="525" mass="56837" checksum="C7D919D0254621D3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJK7</accession>
    <name>A0A151MJK7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0021927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
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        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
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        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TILa_dom"/>
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        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
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        <property type="entry name" value="VWF_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF373">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="TILa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="549"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="940"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="5">
        <location>
            <begin position="1328"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO24643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1756" mass="190315" checksum="C985AC00AD19ADFE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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    <name>A0A151MJT8_ALLMI</name>
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        </recommendedName>
    </protein>
    <gene>
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        <name evidence="11" type="ORF">Y1Q_0014090</name>
    </gene>
    <organism evidence="11 12">
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        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="8496.A0A151MJT8"/>
    <dbReference type="GeneID" id="102571570"/>
    <dbReference type="KEGG" id="amj:102571570"/>
    <dbReference type="CTD" id="84984"/>
    <dbReference type="eggNOG" id="ENOG502RZP1">
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    <dbReference type="PhylomeDB" id="A0A151MJT8"/>
    <dbReference type="Proteomes" id="UP000050525">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="InterPro" id="IPR029412">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539">
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    </dbReference>
    <dbReference type="Pfam" id="PF14933">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO24794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="163" mass="19042" checksum="E339D039E370A91A" modified="2016-06-08" version="1">MTCTAKKCGIHFQPPSIILIYEDQNQEKTRKRIMPIRNFSKFSDCSRAAEQLKNNPRHKAYLESVSLRQLQKLYSLLKGHLKGQSLAQSLEQVQREEAIDPEEDMNKLDDKELAKRKSIMDELFEKNRKKKDDPDFVYNVEVVFPQDEQVESCGWDAESDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLP8</accession>
    <name>A0A151MLP8_ALLMI</name>
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        <recommendedName>
            <fullName evidence="2">Pyrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0019546</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005802">
        <property type="protein sequence ID" value="KYO25373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLP8"/>
    <dbReference type="eggNOG" id="ENOG502SBIG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004020">
        <property type="entry name" value="DAPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02758">
        <property type="entry name" value="PYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrin" evidence="2">
        <location>
            <begin position="5"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO25373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="10407" checksum="BA5BA20B06036925" modified="2016-06-08" version="1">MAKQLLALMDELDEHQFEQFKFLLRHLCPKPRVPWGQLASASQPCTADLLLQHHPRKALALDLAWSLVQSPHHGAAPSHPESAPAPGEQRLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNI1</accession>
    <name>A0A151MNI1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Musculin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MSC</name>
        <name evidence="3" type="ORF">Y1Q_0003757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNI1"/>
    <dbReference type="STRING" id="8496.A0A151MNI1"/>
    <dbReference type="eggNOG" id="KOG4029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151MNI1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF62">
        <property type="entry name" value="MUSCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO25979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9740" checksum="BA6198159869C307" modified="2016-06-08" version="1">MRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQDERYDPGYVHPVSLTWPFVVSGRPESDPKEVSAASRLCGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPR7</accession>
    <name>A0A151MPR7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CCNI</name>
        <name evidence="9" type="ORF">Y1Q_0002161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPR7"/>
    <dbReference type="STRING" id="8496.A0A151MPR7"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20526">
        <property type="entry name" value="CYCLIN_CCNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000006">
        <property type="entry name" value="Cyclin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000052">
        <property type="entry name" value="cyclin-I isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="37"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO26535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="369" mass="40850" checksum="4AFC71D79CF6C80E" modified="2016-06-08" version="1">MGRMLATSGWDAHSSAGEVAPNQDAAVSPAQRDEVIQWLAKLKYQFHLYPETLALAVSLLDRFLAAVKARPKYLNCIAISCLFLAAKTTEEDERIPVLRVLARDSFCGCSPAEIRRMEKIILDKLNWDLHTATPVDFLHIFHAVAISTRPQLLTILPKMTPSQHVASLTKQLLHCMACYQLLQFKGSMLALAIVSLELEKLLPDWLALIIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPPNSVYVYSPLKHTLVTCNRGAFKYHPSSVPGPGFSKDNSRPEVPIKGTAVFYQHLPAPTGCKQASAKRKVEEMEVDDFYDGIKRLYNEDMAPEVVALENVGSVCGADVSRQEGNASPCPPLQPVSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPS7</accession>
    <name>A0A151MPS7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0002169</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPS7"/>
    <dbReference type="STRING" id="8496.A0A151MPS7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10312">
        <property type="entry name" value="Deadenylase_CCR4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000008">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034967">
        <property type="entry name" value="Deadenylase_CCR4b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF35">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="16" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="21">
        <location>
            <begin position="232"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO26545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="594" mass="67351" checksum="E7C95A4613CB8B29" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQB7</accession>
    <name>A0A151MQB7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQB7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="181" mass="20690" checksum="4A839B50DAD477F2" modified="2016-06-08" version="1">MDIKTTTGITADHGQTHPIPCYQSNLSTELDYGEIKDLITICGKEYVQCKLQIRQPRAENTIGILQRSQHSDKNLEILQEVWQKLQTGYLTNGLGRGVASCRYQFPRIFFIKAQRTLGWKSKIKQHCRRGLTAVGTERAKAHTGLYVKCCTQKHKTKTLKDENNCQGHKTWTRCWADCHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR20</accession>
    <name>A0A151MR20_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR20"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="221" mass="24350" checksum="0ED17D55A66D95A6" modified="2016-06-08" version="1">MPPSAHPALAPRYLRTGAARDQICSKSYQFNPSKIVYFFAPFLPLPTCNLNVFPITTCFSWHAKEAATETQSNQHVLPADRRSKGTGGYFQAWRGAVRGGLWPVDKANARSFPSQPVASNGTEKWILQAEWSEAKLQGAPSQESLADSRLKIEVAGLLRVGLFFRHLKTICTAPVTSQEYSFCNLKLGRPKTEEWSNLPEITQQANGTVGNSIQVSGVLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRE9</accession>
    <name>A0A151MRE9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRE9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7455" checksum="BCDD7DFE9EF7118E" modified="2016-06-08" version="1">MVALLLLQPQEAPRTLGSETAQSAWKTSGIHGSASGLLSTTKQSEEDSLSWTCVLLCRYEGRRLYNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MT52</accession>
    <name>A0A151MT52_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pulmonary surfactant-associated protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MBL2</name>
        <name evidence="14" type="ORF">Y1Q_0005242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex of 4 set of homotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SFTPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MT52"/>
    <dbReference type="STRING" id="8496.A0A151MT52"/>
    <dbReference type="eggNOG" id="KOG4297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000045">
        <property type="entry name" value="Pulmonary surfactant-associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015097">
        <property type="entry name" value="Surfac_D-trimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09006">
        <property type="entry name" value="Surfac_D-trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C-type lectin" evidence="13">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO27682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="234" mass="25425" checksum="A5FEB20C574409C1" modified="2016-06-08" version="1">MVTTHPNPDQVVRKWDSNACTLVVCAPAQNGLPGRDGKDGPKGEKGDRGLRGLPGKAGSPGPKGDQGPMGERGPKAECCITEVKHLQNQIRNLQGQLKSLQDIINKKHKVEDFINGSQTNEKLFAANGSAGDYKTSKATCSQAGGHLASPRTSSENGAIQRIIQRYNKAAYLDINDMQTEGIFKYQSVEVIGYANWAPGEPNDTGGEEDCVEMYTDGRWNDRSCGEERLIICEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTB3</accession>
    <name>A0A151MTB3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Y1Q_0005300</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTB3"/>
    <dbReference type="STRING" id="8496.A0A151MTB3"/>
    <dbReference type="eggNOG" id="KOG2052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14220">
        <property type="entry name" value="STKc_BMPR1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23612">
        <property type="entry name" value="TFP_LU_ECD_BMPR1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000001">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000055">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF50">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20" id="KW-0464">Manganese</keyword>
    <keyword evidence="17 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585439" description="receptor protein serine/threonine kinase" evidence="23">
        <location>
            <begin position="24"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="25">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="234"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO27751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="600" mass="68114" checksum="9D6E27AB88014B7E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTB5</accession>
    <name>A0A151MTB5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTB5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO27739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8188" checksum="44574BBEBC9EE677" modified="2016-06-08" version="1">MDYSAFSVCFCTSFFTSDHIFFKNPEIRFKQEQAKDLFMSVVELSFTKAGFSLLPTAFRSKFGTYNLCLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTU0</accession>
    <name>A0A151MTU0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitogen-activated protein kinase kinase kinase 7</fullName>
            <ecNumber evidence="5">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">MAP3K7</name>
        <name evidence="30" type="ORF">Y1Q_0014139</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO27927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTU0"/>
    <dbReference type="STRING" id="8496.A0A151MTU0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14058">
        <property type="entry name" value="STKc_TAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000143">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000152">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049637">
        <property type="entry name" value="MAP3K7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038168">
        <property type="entry name" value="MAPKKK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="17 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="27" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="21" id="KW-0346">Stress response</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="20" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="286"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="340"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="445"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KYO27927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="610" mass="67918" checksum="E867BE84ACC2964F" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTY6</accession>
    <name>A0A151MTY6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Clathrin coat assembly protein AP180</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">91 kDa synaptosomal-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Clathrin coat-associated protein AP180</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SNAP91</name>
        <name evidence="17" type="ORF">Y1Q_0014185</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Binds AP2A2. Interacts with AP2B1; clathrin competes with SNAP91.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO27990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTY6"/>
    <dbReference type="STRING" id="8496.A0A151MTY6"/>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16985">
        <property type="entry name" value="ANTH_N_AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000002">
        <property type="entry name" value="clathrin coat assembly protein AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000001">
        <property type="entry name" value="phosphatidylinositol-binding clathrin assembly protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF4">
        <property type="entry name" value="CLATHRIN COAT ASSEMBLY PROTEIN AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ENTH" evidence="16">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="515"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="738"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="812"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="843"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO27990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="857" mass="87650" checksum="8BFA723275EDFC74" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU55</accession>
    <name>A0A151MU55_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO28027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MU55"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="91" mass="10230" checksum="A483A8E05E639D0D" modified="2016-06-08" version="1">MAPWWRREVLEAEAVTAGSVVVARPPAALSPLSLASAALFVSVFIRVSLPLPTIWVAPPLSSWHWVLRYKKLYLNHRMFLATTLSQEIESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU61</accession>
    <name>A0A151MU61_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Y1Q_0014211</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO28028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MU61"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051051">
        <property type="term" value="P:negative regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859:SF2">
        <property type="entry name" value="PRA1 FAMILY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859">
        <property type="entry name" value="PRA1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO28028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="19120" checksum="D424982087303729" modified="2016-06-08" version="1">MEVQESPLWPWDNFFPRHDSFMQLGLGDMPKWSHHVVSNLLYYQTNYVVLAAAVVSFMGFLHPLNVLLGSAMVVLVFVGFVWVSYNKDILGRFKRQYRTVFMAAIMLSRYFLISCVGAVMVFIFGITLPLLLTFIHASLRWDPSSLEPLETSTPQHPSVHQRILVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVX5</accession>
    <name>A0A151MVX5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0016043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004822">
        <property type="protein sequence ID" value="KYO28696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVX5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="67" mass="7225" checksum="ACD3B1866BDD599B" modified="2016-06-08" version="1">MIPCTSDEDQCIEFTGILVAGNVTLLKSAFGCGSPGICDKRFGVTKYIKNTFDILTDVACYPAPHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYA6</accession>
    <name>A0A151MYA6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0020200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03004669">
        <property type="protein sequence ID" value="KYO29494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYA6"/>
    <dbReference type="KEGG" id="amj:102570403"/>
    <dbReference type="eggNOG" id="KOG1584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="7">
        <location>
            <begin position="101"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO29494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="358" mass="39878" checksum="69DC6B43B0695351" modified="2016-06-08" version="1">MASPRARGASSATDSTSAQPKAGALAAAVALTSPFSRTQACGTEGDPRPGSARPQVSHLPPRMSEDPPGQERRPLVAVDGVPLPEKTWENWAQIKAFQAKPDDLLICTYPKAGTTWIQEIVDMIQQGGDPEKCRRAPLHERHPFLEWARSPQSTGVAWADAMPPPRTLKTHLPVKLLPASFWEQGCKVVYMARNPKDSAVSYYHFLRMHQLLPQPGPWPQFLEAFMAGTVPWGSWHEHVRGWWRAREVLPLLFLHYEDLKEDPGREIQRVAQFIGQPLAPAALERVVHHTSFEVMRANPATNRASAPRSVLDQSISPFMRKGTVGDWKNHFTVAQSEHFDRDCASKTAGTGLAFRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZI1</accession>
    <name>A0A151MZI1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0023185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZI1"/>
    <dbReference type="STRING" id="8496.A0A151MZI1"/>
    <dbReference type="KEGG" id="amj:102575772"/>
    <dbReference type="eggNOG" id="KOG3913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19349">
        <property type="entry name" value="Wnt_Wnt7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013300">
        <property type="entry name" value="Wnt7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF78">
        <property type="entry name" value="PROTEIN WNT-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01891">
        <property type="entry name" value="WNT7PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO29845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="349" mass="39240" checksum="19A3B298263329D3" modified="2016-06-08" version="1">MNRKARRWIFHIFLSLGIVYIKIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHKEEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVQVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRMCNKTAQQSNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0C7</accession>
    <name>A0A151N0C7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch-like protein 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KLHL34</name>
        <name evidence="4" type="ORF">Y1Q_0022424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004278">
        <property type="protein sequence ID" value="KYO30187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0C7"/>
    <dbReference type="STRING" id="8496.A0A151N0C7"/>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18473">
        <property type="entry name" value="BACK_KLHL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF8">
        <property type="entry name" value="KELCH-LIKE PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO30187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="541" mass="61233" checksum="006E1B0A8950B0E8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2D8</accession>
    <name>A0A151N2D8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TEKT4</name>
        <name evidence="6" type="ORF">Y1Q_0014328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004153">
        <property type="protein sequence ID" value="KYO30809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2D8"/>
    <dbReference type="STRING" id="8496.A0A151N2D8"/>
    <dbReference type="GeneID" id="102568193"/>
    <dbReference type="KEGG" id="amj:102568193"/>
    <dbReference type="CTD" id="150483"/>
    <dbReference type="eggNOG" id="KOG2685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5788000at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N2D8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="374"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO30809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="447" mass="51344" checksum="B975D3BA6E74C95E" modified="2016-06-08" version="1">MAQGAVLLTREPAPQAVPVRDLPVKLHEVALNTGPDSSCGLATAGFRTAKYLPEEWHQHHYAQYHQAFADRDCSERCRGQAQSLAAATAALAQRTQEESTAKVGERLQDLHFWKSELQKEIQDLAAETELLAAQKVRLERALDATEVPYSIATDNLQCRERRQPPDLVRDQVEVELLKEAELIRNIQELLKRTLMQAVNQMQLNRDHKQICEMDWSDKVETYNIDEKCGRYNNQSTNIQFHPGSAKFEESASTPETWAKFSHDNIYRAERERLASVNLRSLIDNILHDVAEDLRMQCALVDEAFAKRCEEMEDAKHKLEHHLKKTLKEIGDQESNIASLKQAIKDKEAPMKVAQTRLYDRSFRPNVDLCRDPAQFRLISEVEELTESIESLKKQLQESEQSLRNLEDTRMNLEKEIAVKANSIFIDRQKCMAHRTRYPGVLKLAGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2F6</accession>
    <name>A0A151N2F6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Archaemetzincin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Archeobacterial metalloproteinase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AMZ2</name>
        <name evidence="11" type="ORF">Y1Q_0016350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO30952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2F6"/>
    <dbReference type="STRING" id="8496.A0A151N2F6"/>
    <dbReference type="eggNOG" id="ENOG502QVTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052009">
        <property type="entry name" value="Archaemetzincin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32205:SF5">
        <property type="entry name" value="ARCHAEMETZINCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32205">
        <property type="entry name" value="ARCHAEMETZINCIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO30952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="370" mass="41879" checksum="BD653EEFEDEB4750" modified="2016-06-08" version="1">MSNVTLEHISVRKLSLDLPKSVEGSVQFPGIDSSSPAAGVSRGRYAPVPQNSVKEIAVGSKELAARLIHQNPSCYYEESDWISSHPEPTQDFEQFYHDRYRSTPTSQKSAIYVQPIGSFGDSKVSPENYLKWLKDYCEAFYYGLMVKILDPVPVSQTACAFRVNEYTHNLQIHAGDLLQFLKKRKPRDAFCIVGITMIDLYPKESWNFVFGQASLTEGMGIFSFARYDSDFYSASYKGRLKSGKKYPVADYSVFSGYYTPAITSLLLLRSCKTLTHEIGHIFGLRHCQWLQCVMQGSNHLEESDRRPLDLCPICLRKLQSAIRFNIAERYKALLRWMDDVGSGTEAEFGHAAESCSTVESMVMNIQWAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3C8</accession>
    <name>A0A151N3C8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0016994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004108">
        <property type="protein sequence ID" value="KYO31282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3C8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF22">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="2">
        <location>
            <begin position="75"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="3">
        <location>
            <begin position="300"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO31282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="460" mass="51339" checksum="76CC59547C96D3B3" modified="2016-06-08" version="1">MVVLHFISQVLGINMVNKDLHLKLTLIWSVSEISHAIQDTDDSQSFQFTYKEELLGHMLVSGEEPWGPNCKGPDQSKAIDAAEEELRGLHEELKDSSPEAVLIASSHMAKVIGKSFPSNQAFDFVGSIMDGMLSASPMCATAAGHWFNTILREHGDALLDEATCASLEKLTTIHSSPVLRELLPEILCAFLEQFGRTVGQNMPMPTGSIWRRQLRTGQLQAVGNPCRLSMETLDCAFYGDPGLCTLRVLGREWLQPSVKRELGHFVRAPKCTMRGCASWPGQVLQWVSSTTEKLHITGMALISQDNDTLRSMAFALFGAVAGCMKRRRQAYYTSQVRQSLAMLLFYLEDPNLQVAKAKEKPAVLEGLYQTAQRHYMSLWIEIQAASVKFTACRVIYEEGSDFLDLFCSLLANIGAPEVKYITNVQSIKFLIQTPYTPLKNEDDHQLTVDDIYSLVNSNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N458</accession>
    <name>A0A151N458_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">39S ribosomal protein L20, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRPL20</name>
        <name evidence="4" type="ORF">Y1Q_0006130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N458"/>
    <dbReference type="STRING" id="8496.A0A151N458"/>
    <dbReference type="eggNOG" id="KOG4707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_bL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_bL20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO31570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="159" mass="19307" checksum="0C3C506F1036894D" modified="2016-06-08" version="1">MVFLSLQRWIRCRTTERRWRVLEELQYARHFRGRKNRCYSLAIRNIHRAFVKATKARKLKKRFMRTLWITRIEAASLEHGLKYPGFISNLAKCQPKGEDKKAFLMPLEMEKNQKEYFHVSCTIIDVTDIICSCREGLDELLLRLHYNKRYLQKSDNYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6V7</accession>
    <name>A0A151N6V7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit RPN1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0019034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004001">
        <property type="protein sequence ID" value="KYO32255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6V7"/>
    <dbReference type="STRING" id="8496.A0A151N6V7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="4">
        <location>
            <begin position="301"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO32255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="356" mass="38821" checksum="55158C22B214EF1B" modified="2016-06-08" version="1">MLRGVVPRQVTRIGQGKGEAIEAILAALEVVSEPFRSFANTLVDICAYAGSGNVLKVQQLLHICSEHFDSKEKEEEKDKKDKKEKEKKEGSADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEHMPVTPILEGFVILRKNPNYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N783</accession>
    <name>A0A151N783_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">OR111-5</name>
        <name evidence="14" type="ORF">Y1Q_0004201</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003903">
        <property type="protein sequence ID" value="KYO32668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N783"/>
    <dbReference type="KEGG" id="amj:102565507"/>
    <dbReference type="eggNOG" id="ENOG502SMGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N783"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15222">
        <property type="entry name" value="7tmA_OR51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000002">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF84">
        <property type="entry name" value="OLFACTORY RECEPTOR 51Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585795" description="Olfactory receptor" evidence="12">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO32668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="314" mass="35419" checksum="E8456198F5138768" modified="2016-06-08" version="1">MSCLSGNNSTLFMFILTGIPGLEAEHSWLSIPFSSIYLVALVGNCTILFVIKTDSSLHEPMYYFLSVLALTDLGLSLSTMPTVLKIFWLNSREIGFEACFAQLCFVHFFSFVESSVLLAMSFDRYVAICKPLRYTSILTNAKIAMIGLAILGRSTFLPLPLVLMLRRLPFRMSRVLSHPYCLHQDLMRLACADTTFNRLYGLVLVSLIMILDPLLIVMSYALIFKTILGIASWKERLKALNNCLSHIFAVLALYIPMIGLSLVYRFGHHASPLVHVLMANIYLLVPPVLNPIIYSIKTKQIRKGIVRVFVERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8G4</accession>
    <name>A0A151N8G4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Epidermal growth factor receptor kinase substrate 8-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Epidermal growth factor receptor pathway substrate 8-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EPS8L1</name>
        <name evidence="14" type="ORF">Y1Q_0011024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003823">
        <property type="protein sequence ID" value="KYO33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8G4"/>
    <dbReference type="STRING" id="8496.A0A151N8G4"/>
    <dbReference type="eggNOG" id="KOG3557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900029">
        <property type="term" value="P:positive regulation of ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01210">
        <property type="entry name" value="PTB_EPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09540">
        <property type="entry name" value="SAM_EPS8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11764">
        <property type="entry name" value="SH3_Eps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000023">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000071">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000261">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033928">
        <property type="entry name" value="EPS8_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035462">
        <property type="entry name" value="Eps8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF19">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="439"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="400"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="685"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="719" mass="79654" checksum="102242BD319E8565" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8M2</accession>
    <name>A0A151N8M2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Potassium voltage-gated channel subfamily A member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">KCNA10</name>
        <name evidence="20" type="ORF">Y1Q_0014922</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8M2"/>
    <dbReference type="STRING" id="8496.A0A151N8M2"/>
    <dbReference type="KEGG" id="amj:102574910"/>
    <dbReference type="eggNOG" id="KOG1545">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000007">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000021">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004050">
        <property type="entry name" value="K_chnl_volt-dep_Kv1.3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF28">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01510">
        <property type="entry name" value="KV13CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="19">
        <location>
            <begin position="102"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO33126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="574" mass="64002" checksum="3D32EB1C678F7024" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDA8</accession>
    <name>A0A151NDA8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0010531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003332">
        <property type="protein sequence ID" value="KYO34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDA8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="121" mass="13381" checksum="AE74BD4D01AB2E76" modified="2016-06-08" version="1">MHGQEDTSPSSDLRLETPPELQRQIPRHVGHREPAPASPPWSPIPLILLLMSLCLLLLISARIYGAKVMELSQENENPTQCPVSCPDPNTTVPEMPQDQPPDKEVSGAVESQREQVLPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFN7</accession>
    <name>A0A151NFN7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0013830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003146">
        <property type="protein sequence ID" value="KYO35621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFN7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="8864" checksum="0CDF3E0EAF2F330C" modified="2016-06-08" version="1">MKRPSRSLSLLSFPPRVAVWTAKPRARVLRKKLHVAEDFLPSLRSGAGPLSSKSPLKSHFIWHLARMLHHVLIACTGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG02</accession>
    <name>A0A151NG02_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox protein BarH-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BARX2</name>
        <name evidence="12" type="ORF">Y1Q_0010187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the BAR homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014456345.1">
        <property type="nucleotide sequence ID" value="XM_014600859.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG02"/>
    <dbReference type="STRING" id="8496.A0A151NG02"/>
    <dbReference type="GeneID" id="102566500"/>
    <dbReference type="KEGG" id="amj:102566500"/>
    <dbReference type="CTD" id="8538"/>
    <dbReference type="eggNOG" id="KOG0488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000103">
        <property type="entry name" value="Homeobox protein BarH-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF15">
        <property type="entry name" value="BARX HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="273" mass="30582" checksum="5A9FD145745737F8" modified="2016-06-08" version="1">MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSLYSVCPSLLVRPKPLHSCTGSPPVRAYPLISIITRQPSVVSHIIPAASSSRVLSPQSSSTGASSETLVSETPASSESEAEQPTPRLKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTWYQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPSSEEIEAEEKMNSQAQQEALEASQVPEKPESTEEKRDVSSEMGKSLEHTPETSPEDMVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGI4</accession>
    <name>A0A151NGI4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell death-inducing p53-target protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LITAF-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CDIP1</name>
        <name evidence="14" type="ORF">Y1Q_0009283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003035">
        <property type="protein sequence ID" value="KYO35936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGI4"/>
    <dbReference type="STRING" id="8496.A0A151NGI4"/>
    <dbReference type="eggNOG" id="ENOG502S2GM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098560">
        <property type="term" value="C:cytoplasmic side of late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098574">
        <property type="term" value="C:cytoplasmic side of lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF7">
        <property type="entry name" value="CELL DEATH-INDUCING P53-TARGET PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="13">
        <location>
            <begin position="173"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO35936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="259" mass="28239" checksum="5E8841D82C02808C" modified="2016-06-08" version="1">MLKRYPESEKVENHSALRASSDQEDFQATQLRQEFYFLNSIKASELPIFRKKEEQSQAMSSSPPPPYPGGPSAPLIEEKNGPPPTSGGIASAVNQPQGTHTPPSDFGPPPYEPPLQPGYIPPHMPTEGSGPYMSHGYYPPPGPHPSMGYYPGPEHYPSPDGRTATVIVPSGAATTVTVLQGEIFQGAPVQTVCPHCQQAITTKITYEVGLMNFLLAFFCCFVGCDAGCCFLPCLIDDFKDVTHTCPNCKAYIYTYKRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGQ4</accession>
    <name>A0A151NGQ4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOB kinase activator 3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MOB3A</name>
        <name evidence="2" type="ORF">Y1Q_0011994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003034">
        <property type="protein sequence ID" value="KYO36006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014455354.1">
        <property type="nucleotide sequence ID" value="XM_014599868.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019345496.1">
        <property type="nucleotide sequence ID" value="XM_019489951.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059575468.1">
        <property type="nucleotide sequence ID" value="XM_059719485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGQ4"/>
    <dbReference type="GeneID" id="102569208"/>
    <dbReference type="KEGG" id="amj:102569208"/>
    <dbReference type="CTD" id="126308"/>
    <dbReference type="eggNOG" id="KOG1903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NGQ4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="216" mass="25560" checksum="11A5E14CA640F645" modified="2016-06-08" version="1">MSNALKQVFNKDRTFRPKRKFEPGTQRFELHKRAQASLNAGLDLKLAVQLPSGEEQNDWVAVHVVDFFNRINLIYGTISDYCTEQSCPIMSGGPKYEYRWQDEHKYRKPTALSAPQYMNLLMDWIEVQINNEDIFPTNVGTPFPKNFLQVVKKILSRLFRVFVHVYIHHFDRITQMGSEAHVNTCYKHFYYFVKEFNLIDTKELEPLKEMTSRMCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGR5</accession>
    <name>A0A151NGR5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003035">
        <property type="protein sequence ID" value="KYO35950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGR5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9933" checksum="75C8AC4051BF60AA" modified="2016-06-08" version="1">MADRDSPSAKGEAAALNPGAAHQVSQTPRAIQMRRLWREQRTQREGWQEEVIWEEWLHQQQAQDFQTQVLQELHQFHHDHAVAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGU9</accession>
    <name>A0A151NGU9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003023">
        <property type="protein sequence ID" value="KYO36032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGU9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="82" mass="9081" checksum="D601867DC9B6F616" modified="2016-06-08" version="1">MPGNPEAKSSEAPMSPGLHTLLLAGPDVGSRAHRCLPSAISTDRGQIGSRLRPWEEKQERRHTSRSQLTRREENRANPGKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGZ7</accession>
    <name>A0A151NGZ7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003034">
        <property type="protein sequence ID" value="KYO36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGZ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9130" checksum="99B822F5A0CB1258" modified="2016-06-08" version="1">MGTKPPLLRKRNKERNLSGFPANASPSGRVLASLSSGEFLVPSSDTSGHCQYVLDQLAPGSELQRSSLNPGFPDVLLLMQVSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHY9</accession>
    <name>A0A151NHY9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mast cell protease 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0013149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHY9"/>
    <dbReference type="STRING" id="8496.A0A151NHY9"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF81">
        <property type="entry name" value="GRANZYME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="7534" checksum="E43B6EE466C919B1" modified="2016-06-08" version="1">MMCADDPQGLKTPFKGDSGGSLVCDGVAQGIVSFGNQDGRPPAVFTRISAFMPWIWKTMRPMGEGGAKDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK85</accession>
    <name>A0A151NK85_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Basal body-orientation factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 176</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BBOF1</name>
        <name evidence="13" type="ORF">Y1Q_0008919</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BBOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002792">
        <property type="protein sequence ID" value="KYO37214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006268407.1">
        <property type="nucleotide sequence ID" value="XM_006268345.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK85"/>
    <dbReference type="GeneID" id="102558409"/>
    <dbReference type="KEGG" id="amj:102558409"/>
    <dbReference type="CTD" id="80127"/>
    <dbReference type="eggNOG" id="ENOG502QRCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="441129at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NK85"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032777">
        <property type="entry name" value="DUF4515"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF5">
        <property type="entry name" value="BASAL BODY-ORIENTATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14988">
        <property type="entry name" value="DUF4515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4515" evidence="12">
        <location>
            <begin position="80"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="88"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="235"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO37214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="527" mass="61266" checksum="4AE5C0AC2840FBD0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NL51</accession>
    <name>A0A151NL51_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0015259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002692">
        <property type="protein sequence ID" value="KYO37523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NL51"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586158" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO37523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8605" checksum="88DBE5A2A09BDFBD" modified="2016-06-08" version="1">MLQASSCGLRLLAGLCTGVTVTQTKFVTVRNGANFLEPETSLHSGQQQQSTARGGHDHEPLSRYTPLTPACSGTCSPRDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNA3</accession>
    <name>A0A151NNA3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monocarboxylate transporter 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SLC16A2</name>
        <name evidence="3" type="ORF">Y1Q_0015575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNA3"/>
    <dbReference type="STRING" id="8496.A0A151NNA3"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015349">
        <property type="term" value="F:thyroid hormone transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000179">
        <property type="entry name" value="Solute carrier family 16 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF123">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO38311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="344" mass="37902" checksum="2B2F3BCEFFCD5884" modified="2016-06-08" version="1">MLQADLPPARRDPSLEFKTAWVGALAMGMIFFCSPIVSIFTDRIGCRATAASGATVAFIGLLSSSFTKSLEVRYFTYGILFGCGSSFAFQPSLDGQDKLASRSMKQQCRNQMQNYFSMRVFRKKTYRIWAFGIATAVLGYFVPYVHLIKYVEEAFKEDQKEWILLVCLGAMSGLGRLVSGRIGDCIPGLKKIYLQVASFMLLGLMCMMIPQCQKFEDVIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGYLHDYFGTYHPSFYFAGIPPIIGGLVLSVVPLVHQRMLKKQQPDSGKDKMLVSETVMNGELLPGCPTTEAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNY3</accession>
    <name>A0A151NNY3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protocadherin-11 X-linked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PCDH11X</name>
        <name evidence="2" type="ORF">Y1Q_0015712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNY3"/>
    <dbReference type="STRING" id="8496.A0A151NNY3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="106" mass="11829" checksum="D9F0A23D2FB0F50E" modified="2016-06-08" version="1">MPWITILDEMLVNGLCDRIHIEKNRGQTVSQRRVTFHLPDGSQESCNDSGLGDHEPNSNASTSHPLPLGFPQEEYYEQASPNSRTEGDGNSDPESNFILRGLFQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP74</accession>
    <name>A0A151NP74_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP74"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7726" checksum="F9D16939549E28FF" modified="2016-06-08" version="1">MSQKGLGTCPELTSEDSTLAEPGAGKIKQQHLRCPNESSDNTGVEGDGAPQKTHYYHTWHIENHCITSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP81</accession>
    <name>A0A151NP81_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP81"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="106" mass="12237" checksum="8C84E6F2C0F144BB" modified="2016-06-08" version="1">MDHGRDRERISATNLYIWACLYGLIPKSRTAAKPRMTPVHLFEASFTLPVETGRRDHSANQRGLPFVWTLIFNPSRKYALKNEYKRRMKLSASALIPEEKHHAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPD4</accession>
    <name>A0A151NPD4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cadherin-related family member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0023401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPD4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF441">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="802"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="116"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="228"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="335"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="439"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="549"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="7">
        <location>
            <begin position="676"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO38697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="923" mass="102815" checksum="9B90193AF158B9B6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQ27</accession>
    <name>A0A151NQ27_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP-sugar pyrophosphatase</fullName>
            <ecNumber evidence="9">2.7.7.96</ecNumber>
            <ecNumber evidence="2">3.6.1.13</ecNumber>
            <ecNumber evidence="8">3.6.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">8-oxo-dGDP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nuclear ATP-synthesis protein NUDIX5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside diphosphate-linked moiety X motif 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NUDT5</name>
        <name evidence="16" type="ORF">Y1Q_0023442</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32063"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:63715"/>
            <dbReference type="EC" id="3.6.1.58"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:10412"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-ribose 5-phosphate + ATP + H(+) = ADP-D-ribose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:50248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="2.7.7.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Interacts with PARG.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.96" evidence="9"/>
    <dbReference type="EC" id="3.6.1.13" evidence="2"/>
    <dbReference type="EC" id="3.6.1.58" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQ27"/>
    <dbReference type="STRING" id="8496.A0A151NQ27"/>
    <dbReference type="KEGG" id="amj:102562108"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NQ27"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="15">
        <location>
            <begin position="60"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00084011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO38749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="220" mass="24780" checksum="8EB02A4F0CFE625F" modified="2016-06-08" version="1">MEDKASVDLPKATRETILKNEVIAEGKWVKLEETTYVDRLGKTRIWECIKRTTRKEGMPADGVAVIAVLQRTLHYDCIVLVKQFRPPMGGYCLEFPAGLIDENESPESAALRELEEETGFKGEVTECSPVLCLDPGLTNCTTYLVNVAINGDDSQNVRPKQKPEEGEFVEVVSLPKNDLLQRIEELKAEEHIVVDARLYSYALALKHATEKPLEVPFMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQD9</accession>
    <name>A0A151NQD9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002395">
        <property type="protein sequence ID" value="KYO38988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQD9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7398" checksum="910AFC470D306C7A" modified="2016-06-08" version="1">MSSFARAADNHVCVKVWACGEAVLCDHSVLYKSSQPARAGLIDGQWKSLVRFTCVFGELRAVPTAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRE0</accession>
    <name>A0A151NRE0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 136 family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM136-1</name>
        <name evidence="8" type="ORF">Y1Q_0022608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002395">
        <property type="protein sequence ID" value="KYO39035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRE0"/>
    <dbReference type="GeneID" id="102569914"/>
    <dbReference type="KEGG" id="amj:102569914"/>
    <dbReference type="eggNOG" id="KOG4474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="506011at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042512">
        <property type="entry name" value="TLCD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898:SF1">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="39"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO39035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="247" mass="27798" checksum="1F7DF10440C17A49" modified="2016-06-08" version="1">MDWVPFLLPSMMLPIILQVACSLSGWLFLYAIFCSWNENRSYEWSCRLVTLSHGAVVTFLSGYIVLVDGPSPLTHAGSPNTPLQVCAFSIALGYFIFDLSWCLYFQTEGILMLAHHALSICGMAIVLGIGRSATEVNAVVFVSEITNPLLQARWFLRETGRYHSWLGGMVDFFFVLLFLVLRIGAGAWIMYAMVTSPEPMWLLKVGGLAMYIVSLGFMVKICRFAKRKMMKKYNAWKSMKSKDTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRP9</accession>
    <name>A0A151NRP9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRP9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7575" checksum="5EB94EFD369BF250" modified="2016-06-08" version="1">MTQTTVLTHLKFLVSVRIHRKKFSSHVGARDSNKNTAQLAQGVHRKLSLLASDPAHNTKKGGKKEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSJ5</accession>
    <name>A0A151NSJ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5'-AMP-activated protein kinase subunit beta-2 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRKAB2-1</name>
        <name evidence="9" type="ORF">Y1Q_0006708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSJ5"/>
    <dbReference type="STRING" id="8496.A0A151NSJ5"/>
    <dbReference type="GeneID" id="102560973"/>
    <dbReference type="CTD" id="5565"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000139">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF92">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="8">
        <location>
            <begin position="184"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO39831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="274" mass="30648" checksum="B19B9470D6034882" modified="2016-06-08" version="1">MGNTTSERVSGERHGSKSHRSDGASSAHSSKEHPHKIMVGSTDDPNVFSTHDSKLPGDKEFVSWQSDLDESAKPVQQARPTVIRWADGGKEVFISGSFNNWSAKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQMGTINNLIHVKKSDFEVFDALKVDSLESSETSCRDLSSSPPGPYGQEMYVYRPEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NT41</accession>
    <name>A0A151NT41_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002142">
        <property type="protein sequence ID" value="KYO39923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NT41"/>
    <dbReference type="eggNOG" id="ENOG502TAKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="206" mass="22062" checksum="75EC60CAB70309E3" modified="2016-06-08" version="1">MNSWLSFSPDSFTDSSSVLLLGPVAGEGATDPAHLACVIRGVSNLVQVSWHIPGEEPAQGLPRLLEASNGSLTLIHGISIPWASWASGAAVTCEVIFNSSGSSVIRHAVYSASPCSWCQQEAMRYMVVGLLVLLMVSLTSLWMCSCSSPAFAASCCPEMSCARPAPQCDCKDELCPCSRDPEQEIPTSGTRRWEVSCHERQAVQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTB1</accession>
    <name>A0A151NTB1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0007560</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03002118">
        <property type="protein sequence ID" value="KYO39994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTB1"/>
    <dbReference type="STRING" id="8496.A0A151NTB1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000157">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="168"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="438"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="544"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="858"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO39994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="887" mass="97500" checksum="A5D94A01B609F683" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU03</accession>
    <name>A0A151NU03_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Interleukin-27 receptor subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">IL27RA</name>
        <name evidence="13" type="ORF">Y1Q_0009010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001975">
        <property type="protein sequence ID" value="KYO40336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NU03"/>
    <dbReference type="STRING" id="8496.A0A151NU03"/>
    <dbReference type="eggNOG" id="ENOG502RF72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052672">
        <property type="entry name" value="Type1_Cytokine_Rcpt_Type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423:SF1">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="238"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO40336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="459" mass="49921" checksum="4C3DCA65F10518F8" modified="2016-06-08" version="1">MSLVVPEDDLEPSGHEFLGLEPFTAYEAQARCGPPWSDWGAPLYFTTPEAAPEGLVDVWRVLNDTEPGRPCLLLWKELDPKLARGVVTSYNVAIPPAPDQAVPCCHARLPCTAPNASISASTHRGRTKPAILSLERTDLPPPQKVQAEAVSGGGLAVSWVAPGVEPRELLVEWAEEMGDPRTLPNWTRCPLEHNHILLPGKFQPEVPYQVRMYALYPRGFGAAPSIRVYVQEGVPSAGPEGLHAQSVSPTASVISWHEIPLRYCHGKLVNYTLYLESATGSLNTNQSVNASERSYWLSGLQPDTAYYLRMSGSTNVGEGPTSAVYVFHTPSSHWQTILGALFGLGLFFLLACIAGIIFRAQLLTLCHKVLPRWCWEKIPDPVHSLVLLQEVPKDTGSLVFSLAPKEPPITHIAIEAPASPNIKTPPSPGPSSSPGDPPPILSGYEKHFMPTPEEVMGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NU33</accession>
    <name>A0A151NU33_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Malonate--CoA ligase ACSF3, mitochondrial</fullName>
            <ecNumber evidence="8">6.2.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-CoA synthetase family member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ACSF3</name>
        <name evidence="13" type="ORF">Y1Q_0017428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>malonate + ATP + CoA = malonyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:32139"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.76"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:32140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.76" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03002028">
        <property type="protein sequence ID" value="KYO40253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NU33"/>
    <dbReference type="STRING" id="8496.A0A151NU33"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090409">
        <property type="term" value="F:malonyl-CoA synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090410">
        <property type="term" value="P:malonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000031">
        <property type="entry name" value="Acyl-CoA synthetase family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000030">
        <property type="entry name" value="Acyl-CoA synthetase family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="11">
        <location>
            <begin position="143"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="12">
        <location>
            <begin position="586"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO40253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="673" mass="73771" checksum="CC84EB866DEA8661" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX56</accession>
    <name>A0A151NX56_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0006278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX56"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="10583" checksum="37E65DE4B442193E" modified="2016-06-08" version="1">MGLQGQRGAFQSQDGDQGVGHLSRSGATHVTLNSSPKLGTEAFQHLPLLLASCYILAGTPFFLYHRYEIAPDLTPDTATSLRLKKPCTEIEWPELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX78</accession>
    <name>A0A151NX78_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TUBGCP5</name>
        <name evidence="12" type="ORF">Y1Q_0006282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX78"/>
    <dbReference type="STRING" id="8496.A0A151NX78"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000005">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="11">
        <location>
            <begin position="284"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="10">
        <location>
            <begin position="729"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO41486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1037" mass="119665" checksum="FEC5FA68143BA6A5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXS7</accession>
    <name>A0A151NXS7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 247 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM247</name>
        <name evidence="3" type="ORF">Y1Q_0011073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001657">
        <property type="protein sequence ID" value="KYO41235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXS7"/>
    <dbReference type="OrthoDB" id="9427125at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029200">
        <property type="entry name" value="TMEM247"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36691">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36691:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15444">
        <property type="entry name" value="TMEM247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO41235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="268" mass="31159" checksum="8B9900A209FDDDFA" modified="2016-06-08" version="1">MGDLHKSLQDSDGDTLTSSDVSHFETESLQIKDEETQADVELSNLESSEYSSQVAGAELREMQAGFELTVQISPLKDNKKQQEHVLMDVPRYTAALSHILDDVTESLDGKSHAVHLEPRAKREGNTLQPEAFSSEDEMNNLEELEQPCTGQVTAVDLDLEKIKWNSAMTRLKYEYEDNEKQRQHEEKMEQIQQQTAQRSFSQGLHGLPRPQNQYALFLYCFIFIHIIYTARELAFYFVMRHYIFCFSIVLYFFFKKIFLDYVNKKRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY57</accession>
    <name>A0A151NY57_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0006424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY57"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="78" mass="8591" checksum="DBFABF87B474630E" modified="2016-06-08" version="1">MGEGPHTEVTAQSGSEADLTFGPWLLGFFSNEGPVAWVRVPALRPRFSQPEQPAAGEQRKELPPVASRWETQKQGFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NY88</accession>
    <name>A0A151NY88_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ethanolamine kinase</fullName>
            <ecNumber evidence="16">2.7.1.32</ecNumber>
            <ecNumber evidence="13">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CHKA</name>
        <name evidence="19" type="ORF">Y1Q_0006331</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>choline + ATP = phosphocholine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12837"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.32"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12838"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ethanolamine + ATP = phosphoethanolamine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13069"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.82"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13070"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.32" evidence="16"/>
    <dbReference type="EC" id="2.7.1.82" evidence="13"/>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NY88"/>
    <dbReference type="STRING" id="8496.A0A151NY88"/>
    <dbReference type="eggNOG" id="KOG2686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05156">
        <property type="entry name" value="ChoK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000005">
        <property type="entry name" value="Choline kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF36">
        <property type="entry name" value="CHOLINE KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO41559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="474" mass="54188" checksum="459CC284272A5C55" modified="2016-06-08" version="1">MKTKFCNGEAEPAPLGGGGLLLGCSAVGPPTAEAGRELATGSEEPLLQQQQPDSRTRRRAFLWCKEFLPGAWRGLREDQLHLAPIRGGLSNVLFQCSLPDTIETIADEPRTVLLRLYGAILQMRSCNKGGSGQAQKENDLTGAEAMVLESVMFAILAERALGPKLYGIFPQGRLEEFIPSRKLDTEELSLPDISAEIAEKMARFHGMKMPFNKEPKWLFGTMEKYLNQVLKIKFTKESRIRKLNKLLSYNLPQEIKSLRSLLEATSSPVVFCHNDCQEGNVLLLEGREDSENQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFKASFLKYPTRKQQLHFFSNYLTAFQNGFENLSNQEKLKIEEEMLTEVNRFALASHFFWGLWSIIQAKISSIEFGYLDYALSRFDAYFDQKKKLKLTTDLERIGLGYLREIKAPSSMHSLCPGEINRKLEEISRAEPDSKVPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYQ1</accession>
    <name>A0A151NYQ1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="22">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">Y1Q_0013875</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="22"/>
    <dbReference type="EMBL" id="AKHW03001549">
        <property type="protein sequence ID" value="KYO41883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NYQ1"/>
    <dbReference type="KEGG" id="amj:102558884"/>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INSULIN RECEPTOR"/>
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        <property type="entry name" value="FU"/>
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        <property type="entry name" value="TyrKc"/>
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    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
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    <keyword evidence="9 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 22" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="930"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="612"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="828"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="993"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1297"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="1129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1003"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 21">
        <location>
            <position position="1027"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1074"/>
            <end position="1080"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1133"/>
            <end position="1134"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000620-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000620-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KYO41883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1352" mass="152753" checksum="68D673E1EEE33553" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0A3</accession>
    <name>A0A151P0A3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cadherin-23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CDH23-1</name>
        <name evidence="14" type="ORF">Y1Q_0022282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P0A3"/>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151P0A3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000141">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000173">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000203">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000228">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000135">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000160">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000166">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000175">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cadherin-23 isoform X1"/>
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        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF31">
        <property type="entry name" value="NEURAL-CADHERIN"/>
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            <begin position="1462"/>
            <end position="1485"/>
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            <begin position="7"/>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
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            <end position="684"/>
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    </feature>
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    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="794"/>
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            <end position="1241"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KYO42443.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1713" mass="190078" checksum="4952786FCAF88EF0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0S7</accession>
    <name>A0A151P0S7_ALLMI</name>
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        <submittedName>
            <fullName evidence="2">Outer dense fiber protein 3-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ODF3L2</name>
        <name evidence="2" type="ORF">Y1Q_0000275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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            <end position="115"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="260" mass="28288" checksum="401C37F223B78B5B" modified="2016-06-08" version="1">MIAARETDASSIPCCVTWVFCCLVPGPGPGRYSLPPTIGFVNHDYTRLTSPAYSLHRRLDDSVYLKDASPGPCYYVEPQLTRFGRARGPAYSMRARAKPRGHPQTPGPGTYSPEKAPLITRRQAPSFTMGTRTACRVTDPVPAPNRYALPSLLGARVPAKPSSPSFTISGRHQKGSYSEDLAQTPGPGRYNSTDPSTYLRRPPAFSMLGRRIAPKPAFQTPGPGTHSPEKVTAHRTRAPAYSLGVRHSDFLTPLIVDVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A151P0W6_ALLMI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001351">
        <property type="protein sequence ID" value="KYO42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="196" mass="22706" checksum="159D5A2FB47F4707" modified="2016-06-08" version="1">MHIDELHDELEEWQQKCIQAELLAKGLREKLLESHAQTEKTTKAVTQEMGKVREFLANYEVLRERNLVLEKELETKGGESEELQAQLKRGAVEKDLCEEQIWALKALLEESSAKEAATDIEREQLRQQIQTSRQQVQALEEENETLQEQKQSLLMELGASTKEGVELRARLQEAEEIQSLKTLFKESTTREQGFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0Y6</accession>
    <name>A0A151P0Y6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0022186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0Y6"/>
    <dbReference type="STRING" id="8496.A0A151P0Y6"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="85"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO42325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="167" mass="17276" checksum="2EA32BC2F2F795DE" modified="2016-06-08" version="1">MVLAGNSSPVCGQLRALSGGRMIAGSLPPRLVKLAQEVGASPAGPAGWAGGNDTGCGEQILSYGQAEKVVIGAVLSLLTLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGEWIFGRLFCNVFIAMDVMCCTASIMTLCVISIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4L3</accession>
    <name>A0A151P4L3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptor 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GPR26</name>
        <name evidence="14" type="ORF">Y1Q_0012843</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001049">
        <property type="protein sequence ID" value="KYO43869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4L3"/>
    <dbReference type="GeneID" id="102562696"/>
    <dbReference type="KEGG" id="amj:102562696"/>
    <dbReference type="CTD" id="2849"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159456at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000095">
        <property type="entry name" value="G-protein coupled receptor 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051880">
        <property type="entry name" value="GPC_Orphan_Receptors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24245">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24245:SF6">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO43869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="336" mass="38567" checksum="0E5489522E7600AE" modified="2016-06-08" version="1">MNIWEVILAFLVVVLILVSLLSNVLVLICFLYSADIRKQVPGLFILNLTFCNLLMTVLNMPLTLAGIIYKNQPGGDQICHVAAFLETFLTTNSMLSMAALSIDRWIAVVFPLSYHSKMRYKDAALILSYTWLHSVSFPIVAASLSWVGFHHLYASCTLYNKRPEDRTQFVIFTGFFHTLSFLLSLIVLCFTYLKVLKVARFHCKRIDVITMQTLVLLVDIHPSVRERCLEEQRRRRQRATKKISTFIGTFVLCFAPYVITRLVELSVDNIDSHWGVISKCLAYSKAVSDPFVYSLLRHQYKKTWKDIINKILKRSSINSSALTNESHSRNTMHTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4P8</accession>
    <name>A0A151P4P8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000975">
        <property type="protein sequence ID" value="KYO44047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4P8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="418" mass="48684" checksum="48AAED324B2AC808" modified="2016-06-08" version="1">MEGIEDMESLKQENFEGLLRVSELEENIARLEWELEMAQSQKEQAEAKVATLESRAQSGKKEGSKELRSLMAAEAEKARAVEQLIAEEAKKSRQREEKLREMQKRMAVWEKKSPEHDMGEQKEKKLRLEVSKNLIAALQEENRSQATQIESLQESLGIWQERCDQAERLVEELRKKLAENHVQVEETRRVIIREMERMKEYTASHEAQQDQKQSLKAEVEVKTKECGELQARWQRAEEERDQCRKEIQSLKDLLKESTAGETAALREREQRLVQAAQTQREQLSVVAEQLEKQVFWANTVCQEQWQELGTLRATLIEAGEWTERARTIYLKGRANPEIQENIGKRIPKEEKGTMTTEPPETEVVVTGKESVPTIVIRLEREWKRWTEQYALELNSLRERVEELSRRNDVGVIPVSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5E6</accession>
    <name>A0A151P5E6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dickkopf-related protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0012059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dickkopf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5E6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039706">
        <property type="term" value="F:co-receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.80.10">
        <property type="entry name" value="Lipase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006796">
        <property type="entry name" value="Dickkopf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039863">
        <property type="entry name" value="DKK1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113:SF31">
        <property type="entry name" value="DICKKOPF N-TERMINAL CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113">
        <property type="entry name" value="DICKKOPF3-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04706">
        <property type="entry name" value="Dickkopf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586682" evidence="8">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Dickkopf N-terminal cysteine-rich" evidence="9">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO44278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="198" mass="22058" checksum="76CF1FB1E1FA9CFB" modified="2016-06-08" version="1">MWALPARLWVLSFLLWPLPVAHGFIWAWMYSLPQHSPDEAALSKSSSPMANGKDLQVTTCSQDRHCAQGLFCDKHFGVCLSLRQEGQYCRQDAHCTRGLSCMFGKCHQTVPDGQEGARCRQDKDCGPAACCARQHGEMVCKKRLVMDESCYVPPGGLAFSINQVCPCQEGLVCRAGAIDQEKAPEYQKSNWRCMKLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P631</accession>
    <name>A0A151P631_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0008129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000746">
        <property type="protein sequence ID" value="KYO44518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P631"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003655">
        <property type="entry name" value="aKRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF142">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF57.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50806">
        <property type="entry name" value="KRAB_RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB-related" evidence="3">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO44518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="185" mass="20597" checksum="EEE009B9C0159E4A" modified="2016-06-08" version="1">MLAVAPDQLQEAFEDVALYFTQNEWELLGDGDKVLYRDQMLRNYQALVSLGYQGPAPDLISRIQRQEVELWVCEEENPGESVWTEGLSSDSSDMEDSWDLLAEENSMDSFPRTKTSVQLAGAGMLSRAEQQPPEEEPANPELVPARNQLPGQWAQRVVGPTDGIQARAHKPKAVLKIESLKSSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PB74</accession>
    <name>A0A151PB74_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin carboxyl-terminal hydrolase 46</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deubiquitinating enzyme 46</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin thioesterase 46</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-specific-processing protease 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0021591</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. USP12/USP46 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PB74"/>
    <dbReference type="STRING" id="8496.A0A151PB74"/>
    <dbReference type="eggNOG" id="KOG1864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000112">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF714">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0085">Behavior</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="USP" evidence="15">
        <location>
            <begin position="35"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO45995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="357" mass="41449" checksum="E26867E425E5DE57" modified="2016-06-08" version="1">MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNETEENNKQELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSGDAINLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYASSTLEHKHKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBJ9</accession>
    <name>A0A151PBJ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminoacyl-tRNA synthetase class Ia domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0006965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000504">
        <property type="protein sequence ID" value="KYO46412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBJ9"/>
    <dbReference type="STRING" id="8496.A0A151PBJ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="6">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO46412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="13162" checksum="51C6F94C79CCAF32" modified="2016-06-08" version="1">MSMFRSGFCLYNGQYACSWVPDFVREKRFGNWLKEARDWAISRNRYWGTPIPLWVSDDFEEEQCYKWGIGSFMTVDTVCSWELILRYMSVSPALLPAKLCPFAPTDNSGLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PD69</accession>
    <name>A0A151PD69_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO47002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PD69"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO47002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9371" checksum="0CDFCE3DD9ACCCE0" modified="2016-06-08" version="1">MNMWKSLPERAVEANMRIRFKKRLDTLMEDSFVRISRQLRHVYGAAPRSSGADGDMRVLASSLPGASGEDGELKESGQENTGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDK8</accession>
    <name>A0A151PDK8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Segment polarity dishevelled-like protein DVL-3 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DVL3</name>
        <name evidence="11" type="ORF">Y1Q_0002208</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DSH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000476">
        <property type="protein sequence ID" value="KYO47197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014456301.1">
        <property type="nucleotide sequence ID" value="XM_014600815.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDK8"/>
    <dbReference type="STRING" id="8496.A0A151PDK8"/>
    <dbReference type="GeneID" id="106736875"/>
    <dbReference type="CTD" id="1857"/>
    <dbReference type="eggNOG" id="KOG3571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PDK8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000001">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000040">
        <property type="entry name" value="segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000014">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024580">
        <property type="entry name" value="Dishevelled_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008339">
        <property type="entry name" value="Dishevelled_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003351">
        <property type="entry name" value="Dishevelled_protein_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF6">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02377">
        <property type="entry name" value="Dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12316">
        <property type="entry name" value="Dsh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01760">
        <property type="entry name" value="DISHEVELLED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01761">
        <property type="entry name" value="DISHEVELLED1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="10">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="250"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="9">
        <location>
            <begin position="440"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO47197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="732" mass="80117" checksum="EFBCD3BA8194F9FE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE86</accession>
    <name>A0A151PE86_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0013983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000483">
        <property type="protein sequence ID" value="KYO47065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PE86"/>
    <dbReference type="STRING" id="8496.A0A151PE86"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO47065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="152" mass="16997" checksum="9E8D5C6B368C8955" modified="2016-06-08" version="1">MTWTIFQDHLEQLQPHLEQQDTNMWLPLPVDTWLALTLFKLATPTSLSGPSLWPGEEHHQRHYPGGVQCPSGPLAVVAGFHALGIPQGIKTLDGTHILVTCLPYSDCPFYSWRGFHSIMLQAVVDYHGTFINVSVNWVGSAHDTHVFQNSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEA8</accession>
    <name>A0A151PEA8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0019991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000474">
        <property type="protein sequence ID" value="KYO47284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEA8"/>
    <dbReference type="STRING" id="8496.A0A151PEA8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO47284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="108" mass="12462" checksum="CD29F809A673DD38" modified="2016-06-08" version="1">MSSHVELDESSSPLTTFTTPFGRYRWLRMPMGISPALDVFQWKLTQELKGLPGIEIVNDDILLLGEGDDKEEAIRDHDAKLQQLLNRCRERKITLDADKIQLRRTEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEJ5</accession>
    <name>A0A151PEJ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ankyrin-2 isoform D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ANK2</name>
        <name evidence="19" type="ORF">Y1Q_0001248</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <location evidence="13">Sarcolemma</location>
            <location evidence="13">T-tubule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000422">
        <property type="protein sequence ID" value="KYO47458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PEJ5"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08804">
        <property type="entry name" value="Death_ank2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000002">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000005">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000007">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000002">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2660:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF49">
        <property type="entry name" value="ANKYRIN-2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
        <property type="entry name" value="UPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
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    <sequence length="3869" mass="427416" checksum="EACC89AFF2B9EB48" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PF88</accession>
    <name>A0A151PF88_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KICSTOR subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0019787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KICS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="PhylomeDB" id="A0A151PF88"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:KICSTOR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular response to glucose starvation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="KICSTOR complex protein C12orf66 homolog"/>
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        <property type="entry name" value="FLJ32549 domain-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0458">Lysosome</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
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    </evidence>
    <sequence length="446" mass="50711" checksum="701EEE6509D02171" modified="2016-06-08" version="1">MGESIPLGAPVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGASWLSLLAGLAHLAAAEKAYHSMTFLGQKLGGQSFFSRKDSIRTIYTSLHNELKKVVTTGRNALGGTAPHLEELLSHLSEQLCFFVQARMEIADFYEKMYTLSSQKFINSEELVNILESILKKYSSRFHHPILSPLESSFQLEVDVLAHLLKAQAQISEWKFLPSLVNLHSAHSKLQTWGQIFEKQRETKKHLFGGQSQKVVQPPHLFLWLMKLKNILLAKFSFYFHEALSRQTTVSEMKTLTAKTNPDYFGKISSFIRKYDAVNVSLIFDNRGSESFQGHGYHHPHSYREAPKGVDQYPAVVSLPNDRPVMHWPNVIMIMTDRTSDLNSLDKVVHFYDDKVQSTYFLTRPEPHFTIVVIFESKKSERDSHFISFLNEISHSLKNSKAFASLKPGSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFK4</accession>
    <name>A0A151PFK4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Palmitoyltransferase</fullName>
            <ecNumber evidence="16">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZDHHC13</name>
        <name evidence="18" type="ORF">Y1Q_0019858</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="16"/>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFK4"/>
    <dbReference type="STRING" id="8496.A0A151PFK4"/>
    <dbReference type="GeneID" id="106736836"/>
    <dbReference type="KEGG" id="amj:106736836"/>
    <dbReference type="CTD" id="23390"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000035">
        <property type="entry name" value="Palmitoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF18">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="17">
        <location>
            <begin position="428"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO47800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="622" mass="71490" checksum="4D96CD9E973B2717" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGG3</accession>
    <name>A0A151PGG3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0010596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000242">
        <property type="protein sequence ID" value="KYO48217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGG3"/>
    <dbReference type="STRING" id="8496.A0A151PGG3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051287">
        <property type="entry name" value="TCR_variable_region"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367:SF18">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1279">T cell receptor</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007587008" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO48217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="129" mass="14269" checksum="7FE8402BA8D75F55" modified="2016-06-08" version="1">MRFLGTAVLVALLDVKQANANSVSQSAGTVTVREGDSVFINCTYSLTGTPYLFWYVQFPNEAPRLLLTQYEAQDEEDEKRRRGFSADLQKDSSSFHLRKTSSQASDSAVYYCALRDTVSPAGGELCKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGL2</accession>
    <name>A0A151PGL2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP synthase F1 subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ATPIF1</name>
        <name evidence="11" type="ORF">Y1Q_0001899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGL2"/>
    <dbReference type="STRING" id="8496.A0A151PGL2"/>
    <dbReference type="GeneID" id="102558812"/>
    <dbReference type="KEGG" id="amj:102558812"/>
    <dbReference type="CTD" id="93974"/>
    <dbReference type="eggNOG" id="ENOG502S8MH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151PGL2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000004">
        <property type="entry name" value="ATPase inhibitor A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000003">
        <property type="entry name" value="ATPase inhibitor B, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO48082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="117" mass="12984" checksum="DE7312FAE98AAFC8" modified="2016-06-08" version="1">MAAGVLRSGLRGAFLMQQQRGWSSGSGADQLGELGKGAGKGGGGGGSIREAGGAFGKRQAAEEERYFREKEREQLAALRKHHEEEIDHHKKQIDLLQKEIERHKYKIKKLKNDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PID8</accession>
    <name>A0A151PID8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpastatin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Calpain inhibitor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CAST</name>
        <name evidence="13" type="ORF">Y1Q_0004114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I27 (calpastatin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PID8"/>
    <dbReference type="STRING" id="8496.A0A151PID8"/>
    <dbReference type="eggNOG" id="ENOG502RHIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010859">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026998">
        <property type="entry name" value="Calpastatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001259">
        <property type="entry name" value="Prot_inh_calpain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10077">
        <property type="entry name" value="CALPASTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10077:SF0">
        <property type="entry name" value="CALPASTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00748">
        <property type="entry name" value="Calpain_inhib"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0789">Thiol protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="470"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="476"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="699"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="808"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO48732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="836" mass="87957" checksum="D5A4D527919BCC1C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PIE5</accession>
    <name>A0A151PIE5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calmodulin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Y1Q_0004177</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PIE5"/>
    <dbReference type="STRING" id="8496.A0A151PIE5"/>
    <dbReference type="eggNOG" id="KOG3684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000530">
        <property type="entry name" value="Potassium calcium-activated channel subfamily N member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000022">
        <property type="entry name" value="Small conductance calcium-activated potassium channel, isoform O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin-binding" evidence="11">
        <location>
            <begin position="491"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO48820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="688" mass="75413" checksum="EBB059459E7AD3D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LY37</accession>
    <name>A0A151LY37_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007084">
        <property type="protein sequence ID" value="KYO17158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LY37"/>
    <dbReference type="STRING" id="8496.A0A151LY37"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO17158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="120" mass="13542" checksum="9594DB25400195B6" modified="2016-06-08" version="1">MLKECPASGGNSNHLWTVRVFCQLGFPSEILTDQGGNFLAEVMNCLWDCCGVQHLKTTTYHPQTNGLVERFNGTLKGMLKAYVDSNPNDWDEKLPHLLFAYREVPQESTGFSPFELVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LY90</accession>
    <name>A0A151LY90_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GLB1</name>
        <name evidence="10" type="ORF">Y1Q_0013971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007065">
        <property type="protein sequence ID" value="KYO17214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LY90"/>
    <dbReference type="STRING" id="8496.A0A151LY90"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000021">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000017">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="3"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="334"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="9">
        <location>
            <begin position="471"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO17214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="569" mass="62823" checksum="FE313E1C005E040C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZM4</accession>
    <name>A0A151LZM4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0015234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006876">
        <property type="protein sequence ID" value="KYO17693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZM4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584626" evidence="3">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO17693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="133" mass="14230" checksum="07E70F9BAD965B17" modified="2016-06-08" version="1">MVAAQGLAWQLLVWAALGLGGAAEPCEGQRRERVGAPEGGGSFVVAALACGLLLALAYGALQAVVKVDEDKDEDKEEEEEEGGEQALANVEHDLRAFLAELRRHQGRAPDQGRGAAGWDLDRLHVTVYELEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1Q0</accession>
    <name>A0A151M1Q0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Nucleolar protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NOL6</name>
        <name evidence="17" type="ORF">Y1Q_0020960</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
            <location evidence="2 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006811">
        <property type="protein sequence ID" value="KYO18444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1Q0"/>
    <dbReference type="STRING" id="8496.A0A151M1Q0"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000005">
        <property type="entry name" value="Nucleolar protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000006">
        <property type="entry name" value="Nucleolar protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3030:FF:000001">
        <property type="entry name" value="Nucleolar protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="179"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="325"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="13">
        <location>
            <begin position="469"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="14">
        <location>
            <begin position="643"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="15">
        <location>
            <begin position="849"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="16">
        <location>
            <begin position="1006"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO18444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1172" mass="131733" checksum="DA875E3FEC22969C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1V7</accession>
    <name>A0A151M1V7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1V7"/>
    <dbReference type="eggNOG" id="ENOG502QWJQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031524">
        <property type="entry name" value="ARMH4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21585:SF0">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21585">
        <property type="entry name" value="FULL-LENGTH CDNA CLONE CS0DC025YL05 OF NEUROBLASTOMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15767">
        <property type="entry name" value="ARMH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="469" mass="48932" checksum="70BE66BA2F9CBBFC" modified="2016-06-08" version="1">MLTTAVTTLNPNSSSAGSKTTVGESNETGRGFSAYLNNPVFMTAATEEKKAEGNVEQSVTAQLSSDEMPTLLPSSRTLDVADDFLAIPAPLVDQTAESEPGTLVPNVASPLQWTAAEGPDFTAKPSSLFTDASLNLEAGPDNGHGGFHATASMVTVPPAVPAPTDDWDDTKVGNISQERGTKQEEIKLDHMVTEPPQTAAGDLGEKDMKGLMPFTASAYATTVNLDENDPAGPSPISVWGKKMSTASADQTVVSVLSTLPADEATAANTVENTEPVEEREHVSLPLPEAVADTQSDVFQTLANTLKGVTQETTVSQETDAALPVLTPADLAMHGATSATEEKSKLVTQLPDVSGITQLLSADYPATLVSSAASHLSPEKTPEVEELVTISNEKAVPALAGPDTTRAGMGMQTEETTSRTTVLATPASVVSSVRRTVVPSVRRISTAVTYGLDQLESEGAKGNRKSCPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2E5</accession>
    <name>A0A151M2E5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0009145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2E5"/>
    <dbReference type="STRING" id="8496.A0A151M2E5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="173"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO18698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="264" mass="30287" checksum="CE6C410C703751BA" modified="2016-06-08" version="1">MVEGFAIEMGQGHPEEAVGREVDVAALWEDEHFQLEQSRETDFRHALHEHLVRRDDEVLRPELMKPDELDLGPSLTEESGPGDVDLASRLSKDQREQAAELIREFADVFQEMPGEAWGVVHRIKTPPGQVIRESWRRIPQKLQNQIKAEIEMMLEKGVICRSHSDWRSPIVVVPKPEGKIRLCIDFRKVNVVVKFDAYPMPRVDELVENIGQACYISTLDLTKGYWQVPVAPEDQEKTAFATPWGHFQFRRILFGLHGVAATFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2J7</accession>
    <name>A0A151M2J7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2J7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="79" mass="9005" checksum="6C6AC45484700CCB" modified="2016-06-08" version="1">MVSLKELQKRGNKLTLSKDDIYIVQMYTVAAKGWCFFSLCGIPPYHQVQNPFSKALQVEFLELHCAETPHTSLESVCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3B3</accession>
    <name>A0A151M3B3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3B3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="8029" checksum="A445AF815FEFA2FF" modified="2016-06-08" version="1">MDPCFIQSSEWTYSKDGLGLNMITHHHLHIQKHPSIDITEQLDTSLAPSGPDPQAAGTSQNCSAEFKFFLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3C0</accession>
    <name>A0A151M3C0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Alkaline phosphodiesterase I</fullName>
            <ecNumber evidence="5">3.1.4.1</ecNumber>
            <ecNumber evidence="19">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nucleotide diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Nucleotide pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">Y1Q_0018966</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14246"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>CTP + H2O = CMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27762"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:27763"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>GTP + H2O = GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29391"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:29392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = AMP + ATP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32039"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:32040"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>UTP + H2O = UMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:29396"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23997"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="5"/>
    <dbReference type="EC" id="3.6.1.9" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3C0"/>
    <dbReference type="STRING" id="8496.A0A151M3C0"/>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004551">
        <property type="term" value="F:dinucleotide phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030505">
        <property type="term" value="P:inorganic diphosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045599">
        <property type="term" value="P:negative regulation of fat cell differentiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030500">
        <property type="term" value="P:regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000010">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="4.10.410.20:FF:000003">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="4.10.410.20:FF:000001">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
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    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
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    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
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    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
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    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
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    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF77">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00201">
        <property type="entry name" value="SO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="30">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="30">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038862"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044879"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044894"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00045010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00045013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KYO19015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="908" mass="103507" checksum="94ABC505E524C550" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4P8</accession>
    <name>A0A151M4P8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PIT54</name>
        <name evidence="12" type="ORF">Y1Q_0022113</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with LGALS1 and laminin.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006597">
        <property type="protein sequence ID" value="KYO19492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M4P8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000002">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF487">
        <property type="entry name" value="SOLUBLE SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1379"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="69"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="179"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="289"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="399"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="508"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="618"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="728"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="838"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="948"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1168"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="1274"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="94"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="204"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="217"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="314"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="424"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="437"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="533"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="546"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="643"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="656"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="753"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="766"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="863"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="876"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="973"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="986"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1083"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1096"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1236"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1299"/>
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    </feature>
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    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1343"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO19492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1462" mass="155399" checksum="1AAC62DC5C0E5C43" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4S9</accession>
    <name>A0A151M4S9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006631">
        <property type="protein sequence ID" value="KYO19420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4S9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="127" mass="13855" checksum="482C79AD8B5110DE" modified="2016-06-08" version="1">MVPPAAHPSILPGIGAAVDSDLLKSSSKKRSMPKKRSRSQVLEVPGLEVAQQKAGHLLPKAQSFQFCKRAKSNQAQRDAYREEAVSGNFLSFADLEHLLGSLNKGTEIQRKVLWAQGSRNSDSDNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M4W4</accession>
    <name>A0A151M4W4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid phosphatase-related protein type 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006584">
        <property type="protein sequence ID" value="KYO19554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M4W4"/>
    <dbReference type="STRING" id="8496.A0A151M4W4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF13">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22036" checksum="126BF33BB0FD0913" modified="2016-06-08" version="1">MSAKERQKSKVTKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFNCYDKSLSMPYIEPTQEAVPFLMLLSLVFAGPSITIMVGEGILYCCLSKRRNGIGTEANINAGGCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTSLNVSCSENSYIVEDICSGSDTTIINDGRFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5G2</accession>
    <name>A0A151M5G2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIA subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GTF2A1</name>
        <name evidence="7" type="ORF">Y1Q_0021028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006558">
        <property type="protein sequence ID" value="KYO19754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5G2"/>
    <dbReference type="STRING" id="8496.A0A151M5G2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000002">
        <property type="entry name" value="Transcription initiation factor IIA subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF7">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO19754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="375" mass="41359" checksum="A4F56C06416BAE4D" modified="2016-06-08" version="1">MASAANTNPVPKLYRSVIEDVINDVREVFLDEGVDEQVLVELKTLWENKLMQSKAVDGFHSEEQQLLLQVQQQQQQQQHHHHHHHHPQPQPQQTLQQQSQPQQVLIPASQQAPQQQVIVPDSKLIQHMNASGMSAAATAATLALPAGVTPVQQILTNSGQILQVVRTANGAQYIIQPQQPVVLQQQVIPQMQPGGVQAPVIQQVLAPIPGGISQQTGVIIQPQQILFTGNKTQVIPTTVAAPAPAQAQIPAAGQPQAQQQQAQPQAPLVLQVDGAGDTSSEEEEDEEEDYDDDEEEDKEKDGGEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYVFSKAIGDAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7M7</accession>
    <name>A0A151M7M7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine-rich glycoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Histidine-proline-rich glycoprotein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HRG</name>
        <name evidence="17" type="ORF">Y1Q_0014847</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006382">
        <property type="protein sequence ID" value="KYO20499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7M7"/>
    <dbReference type="STRING" id="8496.A0A151M7M7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051918">
        <property type="term" value="P:negative regulation of fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010543">
        <property type="term" value="P:regulation of platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000005">
        <property type="entry name" value="Histidine-rich glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050735">
        <property type="entry name" value="Kininogen_Fetuin_HRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814">
        <property type="entry name" value="FETUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13814:SF3">
        <property type="entry name" value="HISTIDINE-RICH GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0280">Fibrinolysis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="3" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584821" description="Histidine-rich glycoprotein" evidence="15">
        <location>
            <begin position="21"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="16">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="16">
        <location>
            <begin position="138"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO20499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="428" mass="48827" checksum="29BB041D92D9D52C" modified="2016-06-08" version="1">MELLARALFLALLLCSSAQSQMTTTSADCAAVETDAGVALDLINKHRRDGYLFSLFRVTDAHEQHTGNSSFLYLTLDVLETTCSVLSGKHWESCTFPDLYSLVFGQCKVIMYTNKEFKKNWLYGYNCTTSSVPYKLTECKDCPVRPEFLEDVEAYRGEAERALVKYNDESNHTKYFKVDKVEKAIRLTADRRGHIIEFSIKETRCSKSTSHVTVSECDFLDDAHAHVGFCETRLLVITEGPEAIDISCEIYDTLLDRCPFLHDHHHCYGHGCRHPPADAHHLQVVIRSIQKDLSITTIPLKKDLDADIPLYVHHRDIIISTIILAVDIITDMYTILNAHHLQVVHHRDIIINTNILAVDIITDMYTNLDARHLQVVVRSTQKDLSISTIPLKKKAITNTALEDYLLHYLPMDRMHFHHLQDLSIAFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M8L9</accession>
    <name>A0A151M8L9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermatogenesis associated 6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SPATA6L</name>
        <name evidence="5" type="ORF">Y1Q_0012689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPATA6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M8L9"/>
    <dbReference type="STRING" id="8496.A0A151M8L9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032027">
        <property type="term" value="F:myosin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042769">
        <property type="entry name" value="SPATA6_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032732">
        <property type="entry name" value="SPATA6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435:SF5">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 6 SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14909">
        <property type="entry name" value="SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 6 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO20839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="417" mass="47103" checksum="B8F11CBFD7DD6AF1" modified="2016-06-08" version="1">MPLKVVVELQIHAVTCPGVFLPEKHGVYLSVCVLGQYKETDCLPPIFPLLFHEKMWFEKVFESATDPAAVMEMLESNVAKFGLTQLVPPVGDDLAFYEESTRDFLFPEPKLMPAYPGVDREVLMKTAPGFPGIAPKIEFSTRTTITELPRQYRKPIRGRNRTRIQRSASVSPTRRSISSTRCKTTKKKDKICKRLTRSLRSHSPSPNATKLCREKQLQLSRLSLGSAGYKAGAEVRPPFVVRHVDSNNPFGEKSSPELPHRNVKQNMRPSRDSLEFQLKQALSFDNCEASNTSVKVIREPDEQNTSEHDSSSLDTDELVNYSHSPTQRDSAFQCTASFATSQHHRSPSPAQSHSPPQHSWERIHERVRSLLTSNQARQRLSFGATESEVDEVLERRSCLQKGGTSQQLLETDLKNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MAW1</accession>
    <name>A0A151MAW1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0012733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006284">
        <property type="protein sequence ID" value="KYO21663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MAW1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="111"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO21663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="253" mass="28542" checksum="4CBFA4F639C76DBA" modified="2016-06-08" version="1">MLVVAATKEEHDAILKQVLERARLXXXXFNKDKIQFLVDSGRYTGHIVSKDGVKPDEDKVEATNRMPPPTDKKGLQRLLGTIQCLAQHIPRESSLTALLRALLRNGVIWQWGPEHQEALDKLXXXITTAPVLRYVNPAEQLEFQADASKDXXXXCLFQQKQPVAYALKALTQSERNYXXXXKELLAIVFAMTEFHQYVYGTQAWVQVGHRPLGAIFAKPVGKAPPQLQRTLLELQKDDVQILCTEGKDKLNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB02</accession>
    <name>A0A151MB02_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-actinin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0000417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MB02"/>
    <dbReference type="STRING" id="8496.A0A151MB02"/>
    <dbReference type="eggNOG" id="KOG0035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MB02"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000113">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000005">
        <property type="entry name" value="Actinin alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000105">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000002">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000003">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="31"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="144"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="746"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="809"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO21695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="105457" checksum="DAC6738666CA3CBF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB04</accession>
    <name>A0A151MB04_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclease HARBI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0000397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MB04"/>
    <dbReference type="PhylomeDB" id="A0A151MB04"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF206">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="239"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO21672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="460" mass="52376" checksum="697B5650573C9918" modified="2016-06-08" version="1">MDASRLELVQALNGRRRQVLALFLASQRRVRHLLVTLTSLTAQLCELFFRTCSREATAVEALTRHRVELCGLLSAGDCELPEDEDIRDTNQDGLLWDHLQTVYRQFWVREKSGDWWERVVLQTWDDQHWLENFRMTKATFLEICMELTPELWRRTTNMRLPLTVEKRVAIAIWKLANPNCHRSVSNQFGVGKSTAGSAVREVCAAIKKVLGPRFLRLSDPQEVIDGFAYMGFPNCIGAIDGTHIPILCPPHRSSEYINKKGYFSIVLQGVVDHRGRFTHVTTGCAGKVHDARVFRNSSLVPLMRRGAFAHGASSIEINGVTIPPLIIGDPAYPLLPWLMKPYTGPLDPRKELFNFQLSNCRLMTVECAFKRLKTRWRTLNVRLDASERYLPNMVMACCVLHNICETRGEPLGVGWAAEAERLSQRYEQPEPAPLVNHNQQGNLVRETLANYFAQGLELQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB47</accession>
    <name>A0A151MB47_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dual serine/threonine and tyrosine protein kinase</fullName>
            <ecNumber evidence="5">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Dusty protein kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Receptor-interacting serine/threonine-protein kinase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">DSTYK</name>
        <name evidence="26" type="ORF">Y1Q_0003383</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03006286">
        <property type="protein sequence ID" value="KYO21640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MB47"/>
    <dbReference type="SMR" id="A0A151MB47"/>
    <dbReference type="STRING" id="8496.A0A151MB47"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044344">
        <property type="term" value="P:cellular response to fibroblast growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13975">
        <property type="entry name" value="PKc_Dusty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000244">
        <property type="entry name" value="Dual serine/threonine and tyrosine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051302">
        <property type="entry name" value="Dual_SerThr-Tyr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392">
        <property type="entry name" value="DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392:SF1">
        <property type="entry name" value="DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="631"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="660"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO21640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="908" mass="103102" checksum="94CFDFBFA260E9D1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBM7</accession>
    <name>A0A151MBM7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fibroblast growth factor</fullName>
            <shortName evidence="9">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FGF4</name>
        <name evidence="10" type="ORF">Y1Q_0000552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBM7"/>
    <dbReference type="STRING" id="8496.A0A151MBM7"/>
    <dbReference type="eggNOG" id="KOG3885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151MBM7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23316">
        <property type="entry name" value="beta-trefoil_FGF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000033">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0339">Growth factor</keyword>
    <keyword evidence="8" id="KW-0497">Mitogen</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007358818" description="Fibroblast growth factor" evidence="9">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO21879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="192" mass="21873" checksum="F6F8340E5EAC2F0D" modified="2016-06-08" version="1">MTLPSAFLPILLLGLLSPWVVRCVPFAAQHNDTLEWRWETLFSRSMARLPGERKELSRDGDYLLGIKRLRRLYCNVGIGFHIQVLPDGRINGIHNENRYSLLEISPVERGVVSLFGVKSGLFVAMNSKGKLYGSTHFNDECKFKEILLPNNYNAYESRIYPGMYIALSKNGRTKKGNKVSPTMTVTHFLPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCI9</accession>
    <name>A0A151MCI9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Basement membrane-specific heparan sulfate proteoglycan core protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0021968</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006249">
        <property type="protein sequence ID" value="KYO22221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCI9"/>
    <dbReference type="STRING" id="8496.A0A151MCI9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05743">
        <property type="entry name" value="Ig_Perlecan_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000349">
        <property type="entry name" value="Basement membrane-specific heparan sulfate proteoglycan core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000088">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000113">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SEA" evidence="14">
        <location>
            <begin position="109"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="442"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="16">
        <location>
            <begin position="581"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO22221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="789" mass="86918" checksum="630B7E2BB296735B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MDJ7</accession>
    <name>A0A151MDJ7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0003103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MDJ7"/>
    <dbReference type="STRING" id="8496.A0A151MDJ7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="242" mass="27498" checksum="B66120C4BB723594" modified="2016-06-08" version="1">MGKSGDKRKAPLQPLPIIAQPFQRVGIDIVGPLRHKTCIGKKYILTLVDFATRYPEAIALTSTEAPVVADALTKIFFQLGFPSEILTDRGGNFLVEVMKCLWDCCGVKHLKTTAYHSQTNGLIERFSGTLKGMLKAYVDSNLNDWDKKLPHLLFAYREVPQESTGFSPFELMFERQVRGPLDLVREEWEGKISSTKTSVVKYMLSFRQKLTDMMTVAQDSLGQVQEKQTAWYDEKAHLRTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEH0</accession>
    <name>A0A151MEH0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006228">
        <property type="protein sequence ID" value="KYO22907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEH0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO22907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="135" mass="15200" checksum="F44AC3937B713612" modified="2016-06-08" version="1">MGFLASTCPTTCCNLIPRWREKKAREAARCLLYPNAGVCVSLPICTALQASKEQKQLHEEDVRASPFWHHIFWTPALQRWVLAAQFFSVLSSTACAVLWFCSRLYAGLPPRGEQLYPHSTSTSNIQISVSSQTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEN9</accession>
    <name>A0A151MEN9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO22994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEN9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO22994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="95" mass="10697" checksum="89B0A53D7789DA80" modified="2016-06-08" version="1">MSGLREEQRVANIRASEDGKEENRDYDARVGWVEEEIRTGPSFPHPLPGTCTQSFQGSWSELEESFPLFLTIMAPYTKAMSRLLGPYSDVGSNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFX3</accession>
    <name>A0A151MFX3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Torsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0005689</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 18">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFX3"/>
    <dbReference type="STRING" id="8496.A0A151MFX3"/>
    <dbReference type="KEGG" id="amj:106737507"/>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001719">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017378">
        <property type="entry name" value="Torsin_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF15">
        <property type="entry name" value="TORSIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038079">
        <property type="entry name" value="Torsin_2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585120" description="Torsin" evidence="20">
        <location>
            <begin position="23"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="21">
        <location>
            <begin position="278"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038079-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO23280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="334" mass="37607" checksum="FAF1FB6C4A976D02" modified="2016-06-08" version="1">MKLRSAAGAALGLALLLSPVRALEPVSMGLALAGTAAIAGYVFYRPLHCRFGECCGRRPGGDVETALQKDFQKRLFGQHLVQKVVVKAVTSFLNNANPKKPLTLSLHGCTGTGKNYVSKIIAENIYKAGLNSKYVHLFVSTLHFPHNTKIEQYMEDLQTWIQGNVSECAQSMFIFDEVDKMPPGLIDSIQPFLDYYEKLDGVSYQEAIFIFLSNAGAEKITEVALDYWKSGKKREDISLKELNDVVSQSVFNNKNSGFWHSSLIDRNLIDFFVPFLPLEYEHVKMCVRVEMETRGYPVDEDIVSRVADEMTYFPEEEKLYSRKGCKTIPNADFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MG75</accession>
    <name>A0A151MG75_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006198">
        <property type="protein sequence ID" value="KYO23514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MG75"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO23514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="573" mass="60199" checksum="6AD54AF44DF93F70" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MH01</accession>
    <name>A0A151MH01_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Muscarinic acetylcholine receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CHRM5</name>
        <name evidence="18" type="ORF">Y1Q_0015802</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MH01"/>
    <dbReference type="STRING" id="8496.A0A151MH01"/>
    <dbReference type="KEGG" id="amj:102577235"/>
    <dbReference type="eggNOG" id="KOG4220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045987">
        <property type="term" value="P:positive regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046541">
        <property type="term" value="P:saliva secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15299">
        <property type="entry name" value="7tmA_mAChR_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000047">
        <property type="entry name" value="Muscarinic acetylcholine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000103">
        <property type="entry name" value="Muscarinic acetylcholine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001183">
        <property type="entry name" value="Musac_Ach_M3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF183">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00540">
        <property type="entry name" value="MUSCRINICM3R"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 14 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0770">Synapse</keyword>
    <keyword evidence="12 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="94"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO23806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="602" mass="67635" checksum="7B0E25F6ACB29567" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJ61</accession>
    <name>A0A151MJ61_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-1(XXV) chain isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">COL25A1-1</name>
        <name evidence="3" type="ORF">Y1Q_0002059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006071">
        <property type="protein sequence ID" value="KYO24430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJ61"/>
    <dbReference type="STRING" id="8496.A0A151MJ61"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF3">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO24430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="563" mass="54343" checksum="0C163D473E9821A6" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJ64</accession>
    <name>A0A151MJ64_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRTO4</name>
        <name evidence="11" type="ORF">Y1Q_0023248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the pre-60S ribosomal particle. Interacts with MINAS-60 (product of an alternative open reading frame of RBM10).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261812.1">
        <property type="nucleotide sequence ID" value="XM_006261750.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJ64"/>
    <dbReference type="STRING" id="8496.A0A151MJ64"/>
    <dbReference type="GeneID" id="102576908"/>
    <dbReference type="KEGG" id="amj:102576908"/>
    <dbReference type="CTD" id="51154"/>
    <dbReference type="eggNOG" id="KOG0816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MJ64"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000004">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000002">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="10">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO24557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="238" mass="27600" checksum="D9BC0E2AC00E40C0" modified="2016-06-08" version="1">MPKSKRDKKVSLTKTTKKGLEAKQNLIEELRKCVDTYRYVFIFSVANMRNNKLKDIRTAWKHSRIFFGKNKVMMVALGRGPADEYKENLHKISKYLRGEVGLLFTNRTTNEVNEWFSEFKEMDFARAGNKAPYTVSLDTGPLEQFPHSMEPQLRQLGLPTALKKGVVTLLSDYEVCKEGDVLTPEQARLLKLFGYEMSEFKVTIKCMWNSETGDFQQLAKDTEEPEEMEEEEEDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJ76</accession>
    <name>A0A151MJ76_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0023271</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006061">
        <property type="protein sequence ID" value="KYO24591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJ76"/>
    <dbReference type="eggNOG" id="KOG2514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001043">
        <property type="entry name" value="ciliogenesis and planar polarity effector 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF15">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1000"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1080"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="23">
        <location>
            <begin position="339"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="22">
        <location>
            <begin position="576"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="269"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO24591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1159" mass="132459" checksum="CEDB8CECBE4C8E3B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLU4</accession>
    <name>A0A151MLU4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">B3GNT9</name>
        <name evidence="11" type="ORF">Y1Q_0017011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03005795">
        <property type="protein sequence ID" value="KYO25423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006268228.1">
        <property type="nucleotide sequence ID" value="XM_006268166.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLU4"/>
    <dbReference type="STRING" id="8496.A0A151MLU4"/>
    <dbReference type="GeneID" id="102573502"/>
    <dbReference type="KEGG" id="amj:102573502"/>
    <dbReference type="CTD" id="84752"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030311">
        <property type="term" value="P:poly-N-acetyllactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000020">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF91">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO25423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="412" mass="47542" checksum="09DB9FC9E0385527" modified="2016-06-08" version="1">MKVRLKGDAICTLFLVIALCSLLYSQLEHLGLAGNKEQAHKKPSATQRIFPDPQAPGRYSQEEVIVARPRIIITKKAEVDDYSQTTTVFPLTYSTFDFKSYLLNKDKRNFKLLINQPKKCRRTPGGPFLLIAIKSVVEDFDRREIVRKTWGREGLVHGAQVQRVFLLGIPKNKSALATWETLIHQESQTYRDILLWDFMDTFFNLTLKEIHFLNWANEFCSNVNFIFKGDNDVFVNVENIIDFLERRDPTEDLFVGDIIYNAHPIRVRKSKYYIPETMYGLGMYPAYAGGGGFLLSSQTMKKLSEACKEVELFPIDDVFLGMCLQRINLKPVLHEGFKTFGIVKPSAAPHLQTFEPCFYKDLMVVHSLKVPEIWLMWNLLHSPRLSCTQKKQVKKPFQWKKKTKMITEAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MM94</accession>
    <name>A0A151MM94_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Angiogenin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ANG</name>
        <name evidence="13" type="ORF">Y1Q_0020547</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the pancreatic ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005694">
        <property type="protein sequence ID" value="KYO25642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MM94"/>
    <dbReference type="STRING" id="8496.A0A151MM94"/>
    <dbReference type="GeneID" id="102571789"/>
    <dbReference type="KEGG" id="amj:102571789"/>
    <dbReference type="eggNOG" id="ENOG502S9Q1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8573660at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06265">
        <property type="entry name" value="RNase_A_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.130.10">
        <property type="entry name" value="Ribonuclease A-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001427">
        <property type="entry name" value="RNaseA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036816">
        <property type="entry name" value="RNaseA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023411">
        <property type="entry name" value="RNaseA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023412">
        <property type="entry name" value="RNaseA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437:SF60">
        <property type="entry name" value="ANGIOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00074">
        <property type="entry name" value="RnaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00794">
        <property type="entry name" value="RIBONUCLEASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00092">
        <property type="entry name" value="RNAse_Pc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54076">
        <property type="entry name" value="RNase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00127">
        <property type="entry name" value="RNASE_PANCREATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007747415" evidence="11">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease A-domain" evidence="12">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO25642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="157" mass="18272" checksum="5FD6A5238DEA73B6" modified="2016-06-08" version="1">MTQARTLVMLWVLAGSALLLVVSANQQQYERFLLQHVHCNPRGRDDAYCNRQMRYMLREDRRRDPNPGKKICKEINTFIHETKDAIRAVCQGGGSEYVTRSGQVMHRSFSSFQVTTCRFHGGKPLENCRYRASRDSRRIVIACDEDRNPVHFEESHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMT5</accession>
    <name>A0A151MMT5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMT5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11971" checksum="031A540700C1AE9A" modified="2016-06-08" version="1">MFLETANFVVNYLLSRRPRALTPYRADLEMPFVSSKSRIALHSVYSSRRGLQDYWVSPQRRYPVGSTWRTPSQRLLILPGNTGVSEVESVHWPSCCQYKHKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMX3</accession>
    <name>A0A151MMX3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase with EF-hands</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PPEF1</name>
        <name evidence="17" type="ORF">Y1Q_0012268</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="AKHW03005659">
        <property type="protein sequence ID" value="KYO25901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMX3"/>
    <dbReference type="STRING" id="8496.A0A151MMX3"/>
    <dbReference type="eggNOG" id="KOG0377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07420">
        <property type="entry name" value="MPP_RdgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000226">
        <property type="entry name" value="Serine/threonine-protein phosphatase with EF-hands"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000042">
        <property type="entry name" value="Serine/threonine-protein phosphatase with EF-hands"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000073">
        <property type="entry name" value="Serine/threonine-protein phosphatase with EF-hands"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012008">
        <property type="entry name" value="Ser/Thr-Pase_EF-hand_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000912">
        <property type="entry name" value="PPEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0844">Vision</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="508"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="592"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO25901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="684" mass="79731" checksum="CBA641C0EF4AAC3D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNX0</accession>
    <name>A0A151MNX0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">thiopurine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TPMT</name>
        <name evidence="9" type="ORF">Y1Q_0002021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.</text>
            <dbReference type="EC" id="2.1.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.67" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03005656">
        <property type="protein sequence ID" value="KYO26216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNX0"/>
    <dbReference type="STRING" id="8496.A0A151MNX0"/>
    <dbReference type="eggNOG" id="ENOG502QSF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000101">
        <property type="entry name" value="Thiopurine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00812">
        <property type="entry name" value="Thiopur_methtran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025835">
        <property type="entry name" value="Thiopurine_S-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259:SF11">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO26216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="285" mass="32680" checksum="7D575D2B9105F7A5" modified="2016-06-08" version="1">MISWDQIAGYPNDPTVLHPVKCDRSHLWDTCDSTRLTVRGDWVHIHWTMASSTDLSRIKESSDTGKQQNRVVTEEEWLQKWEANNIGFHNEQGHPLLKKHLDLLLNGRSGLRIFFPLCGKAVEMKWLADMGHSVIGVEFSEQALKDFFVEQNLSYSEGSIPEISKAKVFKSTSGNISLYCCSIYDLSSKIAGKFDGIWDRGALVAINPCDRERYANLMLSLMDKNCSYLLATVSYDPNKYKGPPFYVPEHEIESLFGKFCEIKCLQMQDVFSERQKVWGLDYFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQQ9</accession>
    <name>A0A151MQQ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox protein Hox-A7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HOXA7</name>
        <name evidence="16" type="ORF">Y1Q_0019284</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQQ9"/>
    <dbReference type="STRING" id="8496.A0A151MQQ9"/>
    <dbReference type="eggNOG" id="KOG0489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151MQQ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000017">
        <property type="entry name" value="Homeobox protein antennapedia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF12">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="77"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="79"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO26842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="169" mass="19852" checksum="DB5F36FB925D098F" modified="2016-06-08" version="1">MPGLYNVNSTIYQNPFSSGYSLGSDAYNLHCSSFDQNIPVLCNDLTKSSCEKAEESNLHSQAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKEESSSTPAPNDTTSAAASVEKVEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQY5</accession>
    <name>A0A151MQY5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQY5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="237" mass="26628" checksum="8B025000D155B1BA" modified="2016-06-08" version="1">MDKVLNLHQRCTPVCIDNIIIFLPSWQQHLQDIQAVFQDNRGSETQVSEFWEPRTHKACNSPCAVLRGAGRLRERELQPHTTTRSTERRSTSRRPHLLHRLVCGGGGNKSRGRVTLLSPPRHQHLTQAAHWKMEMDVKGVSPCPEPIPHAQGAGGCQQQQQQRQQDEQPGESASASSASDHPGKRPNSEREDKKHFECLGVTRYSGSLILKCQGDCVEIFWISLNMICGVENNEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR97</accession>
    <name>A0A151MR97_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR97"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="8488" checksum="AE15B410CB9A15C3" modified="2016-06-08" version="1">MREEIISTVMECLDRRWGQWVSQYTEEMNCLGKKLEKLTSRMINGVIDTLLPQKHIKTSLGIEEKQASSAGFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRA6</accession>
    <name>A0A151MRA6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Trifunctional enzyme subunit beta, mitochondrial</fullName>
            <ecNumber evidence="17">2.3.1.155</ecNumber>
            <ecNumber evidence="18">2.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">TP-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">HADHB</name>
        <name evidence="33" type="ORF">Y1Q_0008886</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:21566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31111"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:62418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:31113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31183"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:31185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31091"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:31093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31203"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:31205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:31087"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="29">
            <dbReference type="Rhea" id="RHEA:31089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:18161"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="EC" id="2.3.1.155"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:18163"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear. The mitochondrial trifunctional enzyme interacts with MTLN. Interacts with RSAD2/viperin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 30">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.155" evidence="17"/>
    <dbReference type="EC" id="2.3.1.16" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03005400">
        <property type="protein sequence ID" value="KYO27065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRA6"/>
    <dbReference type="STRING" id="8496.A0A151MRA6"/>
    <dbReference type="eggNOG" id="KOG1392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050633">
        <property type="term" value="F:acetyl-CoA C-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000020">
        <property type="entry name" value="Putative trifunctional enzyme subunit beta mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF153">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16 30" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 30" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="31">
        <location>
            <begin position="93"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="32">
        <location>
            <begin position="370"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00043259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="KYO27065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="513" mass="55134" checksum="7A5630CE9D162D5A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRU7</accession>
    <name>A0A151MRU7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005309">
        <property type="protein sequence ID" value="KYO27149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRU7"/>
    <dbReference type="STRING" id="8496.A0A151MRU7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051576">
        <property type="entry name" value="PX-Rho_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF12">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7960" checksum="89B581FEF6A16A10" modified="2016-06-08" version="1">MSLALKARQKVRRKGAAKDRVFGCDLLEHLQQSGQEGLYWDPGPGLGDRARLDNRRPRFRLAWKQILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV95</accession>
    <name>A0A151MV95_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004914">
        <property type="protein sequence ID" value="KYO28471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV95"/>
    <dbReference type="STRING" id="8496.A0A151MV95"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000020">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="106" mass="11834" checksum="A476C8810C9E3D4D" modified="2016-06-08" version="1">MVMGDVTYGACCVDDYTARALGADFLVHYGHSCLIPIDATQGMKMLYVFVDIKIDTSHFLETVRFNFRPGARLALVSTIQFVSALQVRTLPCCRRQAPALTGFRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXI1</accession>
    <name>A0A151MXI1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">STK19</name>
        <name evidence="3" type="ORF">Y1Q_0002424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004722">
        <property type="protein sequence ID" value="KYO29210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXI1"/>
    <dbReference type="STRING" id="8496.A0A151MXI1"/>
    <dbReference type="eggNOG" id="ENOG502RDW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585555" evidence="2">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO29210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="186" mass="20844" checksum="2C405561229F9FBE" modified="2016-06-08" version="1">MTRCPPLCCATSSTAWCLLAQLWTSTCMKEEGLVRLFQLGFDTDAFGVVFTEDYKAKVVEAVAGKESEALVRRFLDSVLTPCADISYDMVRMMQDFGFRDADITQLVGAGVLTVRDAGSWWLAVPGAGRFMKAFLRGRKAVLALIQKARYREVLLAELQTRRPPRAVRLGLPYHIHDLIGAQLVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXT0</accession>
    <name>A0A151MXT0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Krueppel-like factor 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KLF10</name>
        <name evidence="1" type="ORF">Y1Q_0017989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXT0"/>
    <dbReference type="STRING" id="8496.A0A151MXT0"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="121" mass="13547" checksum="B4765454096ED9FF" modified="2016-06-08" version="1">MLNFGVPLRPAAAAEVGMEVIFKKQSDIRYSWNASTEKSDYEAVEALMSMSCNWKSDFKKYADLRPITPASDMSEENDDSLLSGASDFHAIPAFCLTPPYSPSDFEMSQFAFESPCENTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZM0</accession>
    <name>A0A151MZM0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Complex I assembly factor ACAD9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Acyl-CoA dehydrogenase family member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">ACAD9</name>
        <name evidence="36" type="ORF">Y1Q_0023195</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="27">As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation. This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs. However, in vivo, it does not seem to play a primary role in fatty acid oxidation. In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48184"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74298"/>
            <dbReference type="ChEBI" id="CHEBI:77559"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:48185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(9E)-octadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:77537"/>
            <dbReference type="ChEBI" id="CHEBI:77552"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:48193"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(9Z)-hexadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:77549"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:47305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(9Z,12Z)-octadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:77558"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:48189"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>decanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = trans-2-heptadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74307"/>
            <dbReference type="ChEBI" id="CHEBI:77551"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:48197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:76291"/>
            <dbReference type="ChEBI" id="CHEBI:76292"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:48209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>oxidized [electron-transfer flavoprotein] + (9Z)-octadecenoyl-CoA + H(+) = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47300"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:77553"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:47301"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pentadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48204"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74309"/>
            <dbReference type="ChEBI" id="CHEBI:77545"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:48205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>undecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = trans-2-undecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48200"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:77547"/>
            <dbReference type="ChEBI" id="CHEBI:77548"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48201"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 31">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="28">Homodimer. Interacts with NDUFAF1 and ECSIT. Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with TMEM70 and TMEM242.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 31">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004488">
        <property type="protein sequence ID" value="KYO29859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267641.1">
        <property type="nucleotide sequence ID" value="XM_006267579.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZM0"/>
    <dbReference type="STRING" id="8496.A0A151MZM0"/>
    <dbReference type="GeneID" id="102569095"/>
    <dbReference type="KEGG" id="amj:102569095"/>
    <dbReference type="CTD" id="28976"/>
    <dbReference type="eggNOG" id="KOG0137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MZM0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01161">
        <property type="entry name" value="VLCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000023">
        <property type="entry name" value="Acyl-CoA dehydrogenase family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF9">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 31" id="KW-0274">FAD</keyword>
    <keyword evidence="5 31" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 31" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="34">
        <location>
            <begin position="57"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="33">
        <location>
            <begin position="167"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="32">
        <location>
            <begin position="280"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="35">
        <location>
            <begin position="482"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00055983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00064101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00073945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00076025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="KYO29859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="611" mass="68004" checksum="51700C52143C6145" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N074</accession>
    <name>A0A151N074_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0004742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004317">
        <property type="protein sequence ID" value="KYO30138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N074"/>
    <dbReference type="STRING" id="8496.A0A151N074"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF14">
        <property type="entry name" value="PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO30138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="222" mass="24303" checksum="88A398C3EAE1873F" modified="2016-06-08" version="1">MPGEGPYSRKEITDFFLRVFAAPAPQHHFHTAAFKKPTLCHCCSGLLWGVSKQGYRCQGAFYVATNPPPPQTCLALTYARTHVCPRTSHLMHTCVRTCTSPPDCGMSCHKQCKELVDVECKRRPSLGAMAAPLLPLSSGSDEDLSPMARDVATQTEPPHYELWARLQTLEQERDQLLAMVERLQDQVARLEAGVGGAPAPPLAQLLEGVDALHLPPSPDPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N181</accession>
    <name>A0A151N181_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Timing protein clk-1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">COQ7</name>
        <name evidence="9" type="ORF">Y1Q_0008227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006268128.1">
        <property type="nucleotide sequence ID" value="XM_006268066.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N181"/>
    <dbReference type="STRING" id="8496.A0A151N181"/>
    <dbReference type="GeneID" id="102569098"/>
    <dbReference type="KEGG" id="amj:102569098"/>
    <dbReference type="CTD" id="10229"/>
    <dbReference type="eggNOG" id="KOG4061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N181"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO30583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="207" mass="23054" checksum="76A1F1479B0AB29C" modified="2016-06-08" version="1">MEAALRGLRAGCRRLRGGSGAPRLRSTGAALGGLSKPLLDRIVRVDHAGEFGATRIYAGQMAVLRRTAVAPLIQHMWNQEKEHLKKFNELMVAYRVRPTILLPFWNIAGFALGAGTALLGKESAMACTVAVEESISHHYNNQIRKLMEEDPEKYKELLLIIKQFRDEELEHHDMGLDHNAELAPAYSVLKTAIQIGCRAAIFLSERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2X4</accession>
    <name>A0A151N2X4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CMRF35-like molecule 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CD300LF</name>
        <name evidence="10" type="ORF">Y1Q_0016461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2X4"/>
    <dbReference type="STRING" id="8496.A0A151N2X4"/>
    <dbReference type="KEGG" id="amj:102569240"/>
    <dbReference type="eggNOG" id="ENOG502S7MA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9426888at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05716">
        <property type="entry name" value="IgV_pIgR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000370">
        <property type="entry name" value="CMRF35-like molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050671">
        <property type="entry name" value="CD300_family_receptors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860:SF87">
        <property type="entry name" value="CMRF35-LIKE MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860">
        <property type="entry name" value="POLYMERIC-IMMUNOGLOBULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585690" evidence="8">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="9">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO31108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="297" mass="33723" checksum="41327EA64ADE05DE" modified="2016-06-08" version="1">MVRIFLVWVWILFPGCWALTEPQKVNGTVGGSVLVSCQYSKDYRSYKKYWCRGDNWKLCSVDIQTTGSEEEVRQERLCIRDNHTLCIFTVTMKDLREEDDDTYWCGIEKFGIDLMFLVRVFILPAVPTSPPPDIATSTTSGKEETTDVDVSTIPDFTWAMGEAVNASTIDPVLHIMTPSILLVLFVIILIVVGLVRVSWKKKKDLKKTLQPQNKNFYLCKLKHEADPAQSDMYMNMPPTSSLSLPENDYENLQGMSQASPSTAKHPPAHQEAIYTNMCPGTARLNPRHQQAKRGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5P3</accession>
    <name>A0A151N5P3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004011">
        <property type="protein sequence ID" value="KYO31919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5P3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="83" mass="9190" checksum="FB1445B8734ECA23" modified="2016-06-08" version="1">MNNHVTYHALDHTPYNTQALQCTQGRGHSWQLGCASSAGGGPKTKAGDGCRGLASKAQTRWAEDVIHQNRWWAEDIACENTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6F8</accession>
    <name>A0A151N6F8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0020368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6F8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO32412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8214" checksum="9BC4B08748330EDC" modified="2016-06-08" version="1">MNLATGEFLCCHIFGEATLAHSKDRRQEDLGSSLNSNIKLLGHYSKRLLAEKGLRVLLNLSLLMGLLSHAAHSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8Y7</accession>
    <name>A0A151N8Y7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Prosaposin receptor GPR37L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GPR37L1</name>
        <name evidence="19" type="ORF">Y1Q_0015001</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266139.1">
        <property type="nucleotide sequence ID" value="XM_006266077.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8Y7"/>
    <dbReference type="STRING" id="8496.A0A151N8Y7"/>
    <dbReference type="GeneID" id="102559404"/>
    <dbReference type="KEGG" id="amj:102559404"/>
    <dbReference type="CTD" id="9283"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8960080at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15126">
        <property type="entry name" value="7tmA_ETBR-LP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000059">
        <property type="entry name" value="G protein-coupled receptor 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003909">
        <property type="entry name" value="GPR37_orph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46216:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 37-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46216">
        <property type="entry name" value="PROSAPOSIN RECEPTOR GPR37 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01421">
        <property type="entry name" value="GPR37ORPHANR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585852" evidence="17">
        <location>
            <begin position="19"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="187"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="58"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO33231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="520" mass="57883" checksum="4E6B15FF2E85CA10" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9A7</accession>
    <name>A0A151N9A7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Bifunctional coenzyme A synthase</fullName>
            <ecNumber evidence="21">2.7.1.24</ecNumber>
            <ecNumber evidence="4">2.7.7.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">COASY</name>
        <name evidence="25" type="ORF">Y1Q_0008597</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:18246"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="19">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the central section; belongs to the eukaryotic CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="21"/>
    <dbReference type="EC" id="2.7.7.3" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449663.1">
        <property type="nucleotide sequence ID" value="XM_014594177.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9A7"/>
    <dbReference type="STRING" id="8496.A0A151N9A7"/>
    <dbReference type="GeneID" id="102565422"/>
    <dbReference type="KEGG" id="amj:102565422"/>
    <dbReference type="CTD" id="80347"/>
    <dbReference type="eggNOG" id="KOG3220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N9A7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000899">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000089">
        <property type="entry name" value="Bifunctional coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585854" description="Bifunctional coenzyme A synthase" evidence="23">
        <location>
            <begin position="18"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="24">
        <location>
            <begin position="183"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00061673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00067394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="547" mass="60424" checksum="96D5C4586EB9B05C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAE3</accession>
    <name>A0A151NAE3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KYO33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAE3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585882" evidence="1">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="131" mass="15098" checksum="CCBC645F2C5EB35A" modified="2016-06-08" version="1">MGMCQLCRRRTLYWTLLLDWLLMAAEDQQTDVQMWKLNDTAAQQDRLWVDDMNEEVWDQEDWELRVELQALEHENMKAVWEQGAVVARAVQTTENDHRVLSTILALAVAFVVPTALPLSLAPPAPWQPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAU7</accession>
    <name>A0A151NAU7_ALLMI</name>
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        <submittedName>
            <fullName evidence="13">Collagen alpha-1(IV) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">COL4A1-2</name>
        <name evidence="13" type="ORF">Y1Q_0024495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NAU7"/>
    <dbReference type="KEGG" id="amj:102559838"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NAU7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8 13" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Collagen IV NC1" evidence="12">
        <location>
            <begin position="1456"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="664"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1146"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="861"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1228"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1327"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1350"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1405"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1428"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1681" mass="165786" checksum="26654E620480264D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NB53</accession>
    <name>A0A151NB53_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat and FYVE domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD40- and FYVE domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">WDFY2</name>
        <name evidence="15" type="ORF">Y1Q_0024479</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NB53"/>
    <dbReference type="STRING" id="8496.A0A151NB53"/>
    <dbReference type="GeneID" id="102560117"/>
    <dbReference type="KEGG" id="amj:102560117"/>
    <dbReference type="CTD" id="57590"/>
    <dbReference type="eggNOG" id="KOG1409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NB53"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034141">
        <property type="term" value="P:positive regulation of toll-like receptor 3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034145">
        <property type="term" value="P:positive regulation of toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15756">
        <property type="entry name" value="FYVE_WDFY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000285">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000433">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042733">
        <property type="entry name" value="WDFY1_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF2">
        <property type="entry name" value="WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0853">WD repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="281"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="410" mass="46259" checksum="43D58F40DDE34D6A" modified="2016-06-08" version="1">MAAEIHSRPQSSRPALLSKIEGHQDAVSAALLIPKEDGVITAGEDRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAIMEFHISEDFNKMNFVKTYPAHQNRVSAVTFCLTSEWVISTGHDKCVSWMCTRSGSMLGRHYFTSWASCLQYDFETQHAFVGDYSGQVTLLKLEQNICSVITTLKGHEGSITSLWWDPVQRLLFSGASDHSIIMWDIGGRRGRTLLLQGHHDKVQAICYLQLTRQLVSCSADGGIAVWNMDISREEAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSTKRSSYPIMGFEFQVRVCDSCFESIKDEDRASLATFHEGKHNISHMSMDISRGLMATCGSDRVVKIWDMTPVVGCSLATGFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBN6</accession>
    <name>A0A151NBN6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gastricsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PGCL</name>
        <name evidence="8" type="ORF">Y1Q_0023673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003562">
        <property type="protein sequence ID" value="KYO34226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBN6"/>
    <dbReference type="STRING" id="8496.A0A151NBN6"/>
    <dbReference type="GeneID" id="102562457"/>
    <dbReference type="KEGG" id="amj:102562457"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NBN6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000006">
        <property type="entry name" value="Cathepsin E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000004">
        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF70">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585908" evidence="6">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="73"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="104"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO34226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="388" mass="42820" checksum="641AD9D0CFBBBBA7" modified="2016-06-08" version="1">MKWLVLALVCLQLSEGLVRIPLRKGKSAREIMKEKGTLEHFLKHHKVDLGRKYHFNEYNVAHEPITNYLDAYYFGEISIGTPPQTFLVLFDSGSSNLWVPSTYCQTEACSNHARFDPSQSSTFSSNGQTYTFDYGSGDLTVMMGYDTVSVQDIVVTKQELGLSTNEPTEPFYYSNFDGILGMAYPSLAEGSGLTVMQNMVQQGQLTEPIFSFYFSRQPTYSYGGELILGGIDTQLFTGQITWTPVTQEEYWQIGIEEFAIGQSATGWCSEGCQAIVDTGTLQIAVPQQFMGDFLDAVGAQEGPDSYVVNCTSVQSLPTITFTIGGAQFPLPPSAYISYENGYCSVGIEATYLPSPNGQPLWILGDVFLKEYYSAFDMGNNKVGFAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NC95</accession>
    <name>A0A151NC95_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural killer cell receptor 2B4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0006904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003527">
        <property type="protein sequence ID" value="KYO34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NC95"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042288">
        <property type="term" value="F:MHC class I protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002323">
        <property type="term" value="P:natural killer cell activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024303">
        <property type="entry name" value="NK_rcpt_2B4_Ig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF56">
        <property type="entry name" value="NATURAL KILLER CELL RECEPTOR 2B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11465">
        <property type="entry name" value="Receptor_2B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="247" mass="27560" checksum="E166B453487D7429" modified="2016-06-08" version="1">MKELAELKSLLTLLSSLPFKPPGCQEVKVVAAVGETVQLHPKTWPPSWVTVNWILIVGSQTYWILRHDQNRTSANPLLPFADRVSFHPGNLSLQINSVTEKESGLYTMDLMLGDGSGITNNFRLFVLDRVQQPNIKASTSQECGWCYLTLSCLVPKADRVTYSWSQGASSSPAPEDHWLQQHQADLQVEITKSDNTTFYHCNVSNAISWGMATIDVKMLCNYTNCQEVKVVAAVGETFTDLLDPQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCD9</accession>
    <name>A0A151NCD9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC1A7</name>
        <name evidence="12" type="ORF">Y1Q_0011916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29990"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>K(+)(in) + L-glutamate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-glutamate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003404">
        <property type="protein sequence ID" value="KYO34477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCD9"/>
    <dbReference type="STRING" id="8496.A0A151NCD9"/>
    <dbReference type="eggNOG" id="KOG3787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3860.10:FF:000002">
        <property type="entry name" value="Amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF67">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0769">Symport</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO34477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="618" mass="67669" checksum="D8EEA35BA97B9E97" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDT1</accession>
    <name>A0A151NDT1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0018516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003238">
        <property type="protein sequence ID" value="KYO34946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDT1"/>
    <dbReference type="STRING" id="8496.A0A151NDT1"/>
    <dbReference type="OrthoDB" id="9983389at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="39"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO34946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="208" mass="23013" checksum="D68C0F2E9A5C65DB" modified="2016-06-08" version="1">MSFAPIQLLGSALVFGLRLVGGSRPLWLCWSTVMRPPAPDSFQLTVVALLCGLTTAQRNVTAWVGDNITLPCCFPSQPNISIQHLTLTWQKRWAQGSDWVVHSFYYGKDQLDVQNPAYRGRTRLDPAGLAQGDGALMLRGILEEDRGVYQCHVTTELGRTSEIIQLTVSVDLRDAERPTSGSVSAQQRPGRIFLVGIFLLLTLQTFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEQ9</accession>
    <name>A0A151NEQ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase-activating protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARHGAP28-2</name>
        <name evidence="5" type="ORF">Y1Q_0007878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEQ9"/>
    <dbReference type="STRING" id="8496.A0A151NEQ9"/>
    <dbReference type="eggNOG" id="KOG2200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04391">
        <property type="entry name" value="RhoGAP_ARHGAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000018">
        <property type="entry name" value="Rho GTPase activating protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057323">
        <property type="entry name" value="RHG40/28/18_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF5">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25442">
        <property type="entry name" value="Ubiquitin_RHG40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="327"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00055252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO35274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="676" mass="76587" checksum="9AB8CD2CC5CA8392" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NF10</accession>
    <name>A0A151NF10_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TIMM21</name>
        <name evidence="13" type="ORF">Y1Q_0007961</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NF10"/>
    <dbReference type="STRING" id="8496.A0A151NF10"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000001">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="187" mass="21378" checksum="F21DE5632A55D02A" modified="2016-06-08" version="1">MQKCDVLGANAPQEGSLRAENNSKRVSVQRSQKEEASLSPARKVKEAGRDFTYFIVVLIGIGITGGLFYVIFKELFSSSSPSKIYGDALKKCRAHPEVISVFGEPIKGYGEATRRGRRQHVSHYEYVKDELKYMRLKFYIEGSERGKQGTVHLEVKENPESGKYEFRYIFVDIDTYPRRTIVIVDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFQ0</accession>
    <name>A0A151NFQ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-2-macroglobulin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0018186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003163">
        <property type="protein sequence ID" value="KYO35580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NFQ0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF165">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586032" evidence="6">
        <location>
            <begin position="27"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="7">
        <location>
            <begin position="301"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO35580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="536" mass="59709" checksum="2D57B0AA30462E98" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NFY9</accession>
    <name>A0A151NFY9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NFY9"/>
    <dbReference type="KEGG" id="amj:102559806"/>
    <dbReference type="eggNOG" id="ENOG502S7WW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8846498at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028106">
        <property type="entry name" value="DUF4578"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37342:SF1">
        <property type="entry name" value="CHROMOSOME 11 OPEN READING FRAME 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37342">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC689959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15147">
        <property type="entry name" value="DUF4578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="13511" checksum="159335A7194876AF" modified="2016-06-08" version="1">MGNHCSCGGTWKCPSPFKRKKEKPGTRARHVNPQHQGSRKAQVYTEVPEYPVYATVNKPKSTKRDDSVHYADIQVFTKARERSAEEVKNLQMQNATEYATLNFPRPRLKYDSKNGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NGZ3</accession>
    <name>A0A151NGZ3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DnaJ homolog subfamily B member 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ER-associated DNAJ</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ER-associated Hsp40 co-chaperone</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Endoplasmic reticulum DNA J domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DNAJB11</name>
        <name evidence="10" type="ORF">Y1Q_0013106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003018">
        <property type="protein sequence ID" value="KYO36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006272102.1">
        <property type="nucleotide sequence ID" value="XM_006272040.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NGZ3"/>
    <dbReference type="STRING" id="8496.A0A151NGZ3"/>
    <dbReference type="GeneID" id="102571587"/>
    <dbReference type="KEGG" id="amj:102571587"/>
    <dbReference type="CTD" id="51726"/>
    <dbReference type="eggNOG" id="KOG0713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NGZ3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000040">
        <property type="entry name" value="dnaJ homolog subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051736">
        <property type="entry name" value="DnaJ-B11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586056" description="DnaJ homolog subfamily B member 11" evidence="8">
        <location>
            <begin position="23"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="358" mass="40565" checksum="FE05DE12C6C6CA16" modified="2016-06-08" version="1">MSRRALGRLCLLLLCLLGEATAGRDFYKILGVSRSASIKDIKKAYRKLALQLHPDRNPDDPRAQEKFQDLGAAYEVLSDEEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGNPRQQDRNIPRGSDIIVDLEVTLEEVYSGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVLKHPVFERRGDDLYTNVTISLVEALVGFEMDIAHLDGHKVHVARDKITKPGAKLWKKGEGLPNFDNNNIKGSLIITFDVEFPKEQLTDEQREGLQQLLKQGSVQKVYNGLQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NH83</accession>
    <name>A0A151NH83_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AN1-type zinc finger protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0011987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003034">
        <property type="protein sequence ID" value="KYO35999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NH83"/>
    <dbReference type="STRING" id="8496.A0A151NH83"/>
    <dbReference type="eggNOG" id="KOG3173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF27">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 6 ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO35999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="178" mass="19508" checksum="674C0A313C8EF045" modified="2016-06-08" version="1">MCSVCYKEYLQRQQSSGRISPPAASGPSSSPVASDSSLGQDTEGDTMPEDVKASTQTPVTHQMTAMSISREETSNETVGYVKTEEASSASSSGTLLEISQNSPEGKKASEKPKQKKNRCFTCRKKIGLTGFDCRCGNLFCAMHRYSDMHSCPYDYKAEAAEKIRKENPIIMAEKIQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NKG1</accession>
    <name>A0A151NKG1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">lysoplasmalogenase</fullName>
            <ecNumber evidence="6">3.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMEM86B</name>
        <name evidence="10" type="ORF">Y1Q_0008443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:22544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77287"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:16905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:73359"/>
            <dbReference type="ChEBI" id="CHEBI:77288"/>
            <dbReference type="ChEBI" id="CHEBI:143890"/>
            <dbReference type="EC" id="3.3.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.2" evidence="6"/>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261979.1">
        <property type="nucleotide sequence ID" value="XM_006261917.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NKG1"/>
    <dbReference type="STRING" id="8496.A0A151NKG1"/>
    <dbReference type="GeneID" id="102558009"/>
    <dbReference type="KEGG" id="amj:102558009"/>
    <dbReference type="CTD" id="255043"/>
    <dbReference type="eggNOG" id="KOG4804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2133758at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NKG1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047408">
        <property type="term" value="F:alkenylglycerophosphocholine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="TMEM86B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885:SF6">
        <property type="entry name" value="GH04784P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO37169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="234" mass="25689" checksum="8629F8E98AEAFC31" modified="2016-06-08" version="1">MDILETDAHHRRKLAAEARGRTVRLLPFLVSCALYFGLWLPEPSWPSAVTKILPVLSLVLFIWSESNGSWTPYAQGIFWGLLCSCAGDICLVWPDLFLPGAGAFAIAHLCYLWALGLRPVRPVAFMLTAVVWTATLVCLKPCLDSPVLGCAGIYSALLLAAACRSLSRLPSPHWSPWLVACGFLLFAASDAILVFDRFCLPLPRARLVVMVTYYMAQSLIAASVVGEAIHWKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLQ9</accession>
    <name>A0A151NLQ9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002600">
        <property type="protein sequence ID" value="KYO37756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLQ9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO37756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="8049" checksum="753FF2B3C923D9E7" modified="2016-06-08" version="1">MGKVKEPAAERPRRDQQPATQQGHQQGFPPSSSLASQVERNQQGGFKIIMPTRGLEDADWCIVEQGVKRTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNK8</accession>
    <name>A0A151NNK8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase HERC4 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HERC4</name>
        <name evidence="9" type="ORF">Y1Q_0019511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002540">
        <property type="protein sequence ID" value="KYO38045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NNK8"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000012">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF18">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="79"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="287"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="340"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="723"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO38045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116331" checksum="FAA0579395B097DC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQN6</accession>
    <name>A0A151NQN6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NDUFA2</name>
        <name evidence="17" type="ORF">Y1Q_0004810</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Mitochondrion inner membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002337">
        <property type="protein sequence ID" value="KYO39161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006264521.1">
        <property type="nucleotide sequence ID" value="XM_006264459.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQN6"/>
    <dbReference type="STRING" id="8496.A0A151NQN6"/>
    <dbReference type="GeneID" id="102570940"/>
    <dbReference type="KEGG" id="amj:102570940"/>
    <dbReference type="CTD" id="4695"/>
    <dbReference type="eggNOG" id="KOG3446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NQN6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000127">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="16">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO39161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="102" mass="11318" checksum="58E8659C4CAD3820" modified="2016-06-08" version="1">MAAAAAAVRGIGGSLGRSLKEIRIHLCQRSPGSQGTRDFIEQHYVTLKKANPDFPILIRECSEVKPKLWARYEFGREKCVPLNNLNVDQVAQALENIVKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSY5</accession>
    <name>A0A151NSY5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Filamin-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FLNB</name>
        <name evidence="12" type="ORF">Y1Q_0013035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the filamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002161">
        <property type="protein sequence ID" value="KYO39908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NSY5"/>
    <dbReference type="eggNOG" id="KOG0518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21314">
        <property type="entry name" value="CH_FLNC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000006">
        <property type="entry name" value="Filamin-B isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000042">
        <property type="entry name" value="Filamin-B isoform B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000092">
        <property type="entry name" value="Filamin-B isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000008">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000007">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000079">
        <property type="entry name" value="Filamin-B isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000138">
        <property type="entry name" value="filamin-B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000154">
        <property type="entry name" value="filamin-B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000102">
        <property type="entry name" value="filamin-B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000001">
        <property type="entry name" value="Filamin-C isoform b"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000105">
        <property type="entry name" value="filamin-C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000115">
        <property type="entry name" value="filamin-C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000126">
        <property type="entry name" value="filamin-C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000157">
        <property type="entry name" value="filamin-C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000096">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000118">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000122">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000168">
        <property type="entry name" value="filamin-C isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF12">
        <property type="entry name" value="FILAMIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="23"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="152"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="263"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="363"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="462"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="559"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="655"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="752"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="855"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="954"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1049"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1142"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1237"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1337"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1430"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1526"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1635"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1741"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1810"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1900"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="1992"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="2186"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="2269"/>
            <end position="2362"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="2366"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="9">
        <location>
            <begin position="2503"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2146"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2146"/>
            <end position="2165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO39908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2598" mass="277143" checksum="1A288AFB4522F74C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NTF5</accession>
    <name>A0A151NTF5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Toll-like receptor 2 type-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TLR2A</name>
        <name evidence="20" type="ORF">Y1Q_0004464</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="15">Binds MYD88 (via TIR domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002142">
        <property type="protein sequence ID" value="KYO39960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NTF5"/>
    <dbReference type="STRING" id="8496.A0A151NTF5"/>
    <dbReference type="eggNOG" id="KOG4641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000001">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000046">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF26">
        <property type="entry name" value="TOLL-LIKE RECEPTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0391">Immunity</keyword>
    <keyword evidence="14 16" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3 16" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="19">
        <location>
            <begin position="614"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037595-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO39960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="801" mass="91913" checksum="960F502DD6753D80" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUS3</accession>
    <name>A0A151NUS3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0009546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001922">
        <property type="protein sequence ID" value="KYO40514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUS3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="212" mass="23818" checksum="3E6D4121906643B3" modified="2016-06-08" version="1">MCLQRCSAAPAHRRPARPRTWLLAPEAQVLVRSECTAWQGWELVRDRQLEPLHSAQIRTSPLLPATTLPRASPSAVSSSPARIRCPASRLGVLCPLHCAQRKNKDAGRTTESSGSLIIPKSAAGHPNTQAAHSSEPEEFMVYKFRPEETRQIPARHHRDQDLDSVLVVTWRVIHHSSQFARRELQNSSKNGESQLNVVENNGYHYATRPHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUY3</accession>
    <name>A0A151NUY3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain-containing protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BTBD18</name>
        <name evidence="3" type="ORF">Y1Q_0012229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001868">
        <property type="protein sequence ID" value="KYO40731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUY3"/>
    <dbReference type="STRING" id="8496.A0A151NUY3"/>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18293">
        <property type="entry name" value="BTB_POZ_BTBD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042915">
        <property type="entry name" value="BTBD18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47639">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47639:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO40731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="565" mass="59701" checksum="13FEBC86D394E66C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVQ2</accession>
    <name>A0A151NVQ2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0013728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001786">
        <property type="protein sequence ID" value="KYO40982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVQ2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="148" mass="16655" checksum="D8683358CFA110DD" modified="2016-06-08" version="1">MHLVPLRLFPRTSTDIEAEEVEGQEETHASNMSSTVIKIQKQAGPWKSLVICLLPQPGNSQLARAVAAVDLFPNHRDPWLPGTASCLHYSRALQRFSQQAEMWTPEPGAAAGRAPEQEEPPPERRCPEKWLMILILKQCLKLLTRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXM7</accession>
    <name>A0A151NXM7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Fucosyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FUT6</name>
        <name evidence="22" type="ORF">Y1Q_0011888</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1-&gt;3)-[alpha-L-fucosyl-(1-&gt;4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:133506"/>
            <dbReference type="ChEBI" id="CHEBI:140304"/>
            <dbReference type="EC" id="2.4.1.65"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:23629"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1-&gt;4)-[alpha-L-fucosyl-(1-&gt;3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14257"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:133507"/>
            <dbReference type="ChEBI" id="CHEBI:137941"/>
            <dbReference type="EC" id="2.4.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:14258"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56076"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:136545"/>
            <dbReference type="ChEBI" id="CHEBI:139509"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:56077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-L-Fuc-(1-&gt;4)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62904"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:146021"/>
            <dbReference type="ChEBI" id="CHEBI:146022"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:62905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;3)]-beta-D-GlcNAc derivative + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52864"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:145342"/>
            <dbReference type="ChEBI" id="CHEBI:145343"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>beta-D-galactosyl-(1-&gt;4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1-&gt;4)-[alpha-L-fucosyl-(1-&gt;3)]-N-acetyl-D-glucosamine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:60152"/>
            <dbReference type="ChEBI" id="CHEBI:62287"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:62825"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Golgi apparatus</location>
            <location evidence="1 19">Golgi stack membrane</location>
            <topology evidence="1 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="19"/>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NXM7"/>
    <dbReference type="eggNOG" id="KOG2619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017060">
        <property type="term" value="F:3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017083">
        <property type="term" value="F:4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000001">
        <property type="entry name" value="alpha-(1,3)-fucosyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF11">
        <property type="entry name" value="4-GALACTOSYL-N-ACETYLGLUCOSAMINIDE 3-ALPHA-L-FUCOSYLTRANSFERASE FUT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="20">
        <location>
            <begin position="36"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO41175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="205" mass="24359" checksum="49DFB122CC85C4BA" modified="2016-06-08" version="1">MNGIFNLTMTYRKDSDIFSPYGSLELLRQPHNFTIPAKTKLVAWVVSNWNPGSRRVQYYTELKKYIHVDVYGRQHKPLSQEQFLPTLSQYKFYLAFENSLHEDYITEKLWKNALTSGTVPVVCGPPRQNYERFLPPDSFIHIDDFPSALELAQYLEQLDKDPVRYERYFQWRTWLRPYITPGWIFHYCNACXXXXXXXXXXXXHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYI3</accession>
    <name>A0A151NYI3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hyaluronan and proteoglycan link protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Brain link protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HAPLN2</name>
        <name evidence="16" type="ORF">Y1Q_0004506</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HAPLN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001603">
        <property type="protein sequence ID" value="KYO41813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059574279.1">
        <property type="nucleotide sequence ID" value="XM_059718296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYI3"/>
    <dbReference type="STRING" id="8496.A0A151NYI3"/>
    <dbReference type="GeneID" id="102557933"/>
    <dbReference type="KEGG" id="amj:102557933"/>
    <dbReference type="CTD" id="60484"/>
    <dbReference type="eggNOG" id="ENOG502QV1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5359219at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:glial cell differentiation"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03519">
        <property type="entry name" value="Link_domain_HAPLN_module_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000846">
        <property type="entry name" value="Hyaluronan and proteoglycan link protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000001">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000002">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050691">
        <property type="entry name" value="Hyaluronan_bind_Proteoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804">
        <property type="entry name" value="AGGRECAN/VERSICAN PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804:SF8">
        <property type="entry name" value="HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01265">
        <property type="entry name" value="LINKMODULE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01241">
        <property type="entry name" value="LINK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-0373">Hyaluronic acid</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="49"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="15">
        <location>
            <begin position="165"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="15">
        <location>
            <begin position="261"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO41813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="358" mass="40155" checksum="A7B1841A861F2477" modified="2016-06-08" version="1">MGQYQETGKLLGSCFTMHQLLLLASAYLSSLPAAFTIYQKATGNPAAAPRLQYLLEPLHEVVHTQRGATVTLPCVLRSLPPSYKVKWSKVEPADFLENIVLITNGAQHKNYGHLGARARLRRGHRLDASLTITNVALEDEGRYRCQLVNGLEDESLSLSLQLEGVVFPYQTGNGRYKFNYFEAKRACEEQDSRLATYQQLYKAWTEGLDWCNAGWILDGTVHYPIINSREPCGGRLLLPGIRTYGAKDKQKDRFDAFCFTSAMKGRVYFIRGHLNFKEAGQACRNHGATIAKVGQLYSAWKFSQLDRCDGGWLADGSVRYPITIPRARCGGLPDPGVRSFGFPNKEQRTYGTYCYSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYP6</accession>
    <name>A0A151NYP6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LSM14-like protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM14B</name>
        <name evidence="10" type="ORF">Y1Q_0002655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LSM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYP6"/>
    <dbReference type="STRING" id="8496.A0A151NYP6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF1">
        <property type="entry name" value="PROTEIN LSM14 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="8">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="5">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO42001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="420" mass="46244" checksum="2E5858106F11D633" modified="2016-06-08" version="1">MSSGTPYIGSKISLISKAQIRYEGILYTIDTENSTVALAKDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASTSSFQPHVPYSPFRGMPPYSQLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSEPDMSSESHQLSSKGASFPSLHPVRKSPMVEQAVQTGPIDNMNSQKPPPAKVVPGIQRNGRQIPQSTKTNDTVQPTPVQTQGQVNDENRRPQRRRSGNRRTRNRSRGQNRPTTVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKADTGEEKVDPGVATQNNDGNADEELLGPNCYYDKSKSFFDNISSELKSSSRPFVVDFEVEGVVEQHGETKPLTELVLEECNYGGSNTFHHEGDPFVYRKNTTNCCTNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0K8</accession>
    <name>A0A151P0K8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EMILIN-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EMILIN3</name>
        <name evidence="7" type="ORF">Y1Q_0002808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO42185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275909.1">
        <property type="nucleotide sequence ID" value="XM_006275847.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0K8"/>
    <dbReference type="GeneID" id="102564634"/>
    <dbReference type="KEGG" id="amj:102564634"/>
    <dbReference type="CTD" id="90187"/>
    <dbReference type="eggNOG" id="ENOG502QV8J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="PhylomeDB" id="A0A151P0K8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF2">
        <property type="entry name" value="EMILIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07546">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586554" evidence="5">
        <location>
            <begin position="32"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="6">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO42185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="823" mass="91799" checksum="E4169944E50CD977" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2X0</accession>
    <name>A0A151P2X0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2X0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="70" mass="7805" checksum="443572AB8AD00940" modified="2016-06-08" version="1">METQQGRNSSRNVFGGGSVLLKTKVPDCFGNSTSKLNIKIYVADNNRAKLSSREDYMVDLSEQKPHWLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3A9</accession>
    <name>A0A151P3A9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sphingolipid delta(4)-desaturase DES1</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Degenerative spermatocyte homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Dihydroceramide desaturase-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Retinol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">DEGS1</name>
        <name evidence="29" type="ORF">Y1Q_0013569</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Catalyzes the equilibrium isomerization of retinols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>11-cis-retinol = 13-cis-retinol</text>
            <dbReference type="Rhea" id="RHEA:55356"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:45479"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:55357"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-cis-retinol = 9-cis-retinol</text>
            <dbReference type="Rhea" id="RHEA:55360"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:78272"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:55361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>all-trans-retinol = 11-cis-retinol</text>
            <dbReference type="Rhea" id="RHEA:19141"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19142"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:19143"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>all-trans-retinol = 13-cis-retinol</text>
            <dbReference type="Rhea" id="RHEA:55352"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:45479"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:55353"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>all-trans-retinol = 9-cis-retinol</text>
            <dbReference type="Rhea" id="RHEA:55348"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:78272"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:55349"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:46545"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 26">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3A9"/>
    <dbReference type="STRING" id="8496.A0A151P3A9"/>
    <dbReference type="eggNOG" id="KOG2987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151P3A9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF2">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 26" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 26" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 26" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 26 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="28">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00030541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00045712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KYO43536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="293" mass="34507" checksum="131AE0880012A529" modified="2016-06-08" version="1">MGNTVAREDFEWVYTDQPHADRRKEILAKHPEIKALMKPDRHLIGVVVLMVLAQLIAFYLVKDLDWKWVIFWAYVFGSCISHSMTLAIHEISHNSAFGNCKAMWNRWFGIFANLPLGLPYSISFKRYHMDHHRYLGGDGIDVDIPTDFEGWFFCTRFRKFIWIVLQPLFYAIRPLCINPKPISRLEIINLLAQLSFDVVIYYFWGIKSGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVKKIAAEYYDNLPQYNSWIKVLYDFVMDDTISPYSRMKRHLKGDVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4D0</accession>
    <name>A0A151P4D0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Charged multivesicular body protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CHMP6</name>
        <name evidence="9" type="ORF">Y1Q_0011858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001077">
        <property type="protein sequence ID" value="KYO43830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4D0"/>
    <dbReference type="STRING" id="8496.A0A151P4D0"/>
    <dbReference type="eggNOG" id="KOG2910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO43830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="187" mass="21935" checksum="F22B1BA2FFF80816" modified="2016-06-08" version="1">MGWGWGKQLKQQRDKLRQYQRRLHLQLERERAVARQLLRDGKKEKALFLLKKKRYQEQLLDKTETQISNLERMVQDIEFAQIEMKVIEGLKIGNECLNKMHQVMSIEEVERIIDETQDAVEYQRQIDEMVAGSFTEEDEDAILEELNAITQEQIELPEVPTEPLPEEKIPEASPVKVRPKPELVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5Z0</accession>
    <name>A0A151P5Z0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Disintegrin and metalloproteinase domain-containing protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ADAM28</name>
        <name evidence="18" type="ORF">Y1Q_0016765</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000764">
        <property type="protein sequence ID" value="KYO44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5Z0"/>
    <dbReference type="STRING" id="8496.A0A151P5Z0"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF32">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="17">
        <location>
            <begin position="200"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="16">
        <location>
            <begin position="404"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="621"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="692"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="753"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="789"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="311"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="353"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO44464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="805" mass="89270" checksum="02F055A1756D0ED5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9D3</accession>
    <name>A0A151P9D3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine protease HTRA3 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HTRA3</name>
        <name evidence="12" type="ORF">Y1Q_0021373</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9D3"/>
    <dbReference type="STRING" id="8496.A0A151P9D3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06785">
        <property type="entry name" value="cpPDZ_HtrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.120:FF:000002">
        <property type="entry name" value="HtrA serine peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF14">
        <property type="entry name" value="SERINE PROTEASE HTRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO45701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="405" mass="44099" checksum="C6FB3E546E24B43B" modified="2016-06-08" version="1">MGKRFAKGVCQCKLSYQVCGSDGRTYDNVCQLKAVSRKALQQGLPAVIQIQKGACESGHLQPSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSSNAISGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTESHDKQNKGPFIQPARRKGSEQRNGSFACRSHGKKRFIGIRMLTITPALVEELKHSNADFPDVRSGIYVHEVVPNSPSHRGGIKDGDIIVKVNGRPLITTSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9I4</accession>
    <name>A0A151P9I4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox protein HMX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HMX1</name>
        <name evidence="13" type="ORF">Y1Q_0021366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9I4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000053">
        <property type="entry name" value="H6 family homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO45693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="252" mass="27325" checksum="FACB54D970830E19" modified="2016-06-08" version="1">MMPDEATEQAHSASARVSSFFIENLLGSAGKESRGQRKRGSAEDGHKEPRSLGGIAGSHCAPLCCQVSAFGFSPRRCPLRESPTEWYRRAHAGLLACPSPDTSDRDSPEIAEEAAAERPGPCGTLAEESGAEARAEELACGSGGREEDDRAEEPDSAEQRAAGRKKKTRTVFSRSQVFQLESTFDMKRYLSSAERAGLAASLQLTETQVKIWFQNRRNKIVRVPILYHENSPAGALGFPLPHVSPPLMTGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAI5</accession>
    <name>A0A151PAI5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRAPPC11</name>
        <name evidence="10" type="ORF">Y1Q_0021688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPPC11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAI5"/>
    <dbReference type="STRING" id="8496.A0A151PAI5"/>
    <dbReference type="eggNOG" id="KOG4386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025876">
        <property type="entry name" value="TRAPPC11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12742">
        <property type="entry name" value="Gryzun-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="8">
        <location>
            <begin position="247"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 11 C-terminal" evidence="9">
        <location>
            <begin position="1021"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO46127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1117" mass="126837" checksum="DCA7B90D6AC17F4B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAZ1</accession>
    <name>A0A151PAZ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAZ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="85" mass="9299" checksum="408985400A17D7C2" modified="2016-06-08" version="1">MGEKLLLTKGGKMGNGDEIRDNEEQHSEESSGHPSSCQCDSQSTETGSPIKGGIMNRKNMVHIHHGKAICFTKRQKQIPDVTSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PB60</accession>
    <name>A0A151PB60_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-ketoacyl-[acyl-carrier-protein] reductase beta subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Quinone reductase CBR4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CBR4</name>
        <name evidence="15" type="ORF">Y1Q_0021758</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006275413.1">
        <property type="nucleotide sequence ID" value="XM_006275351.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019336955.1">
        <property type="nucleotide sequence ID" value="XM_019481410.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019336956.1">
        <property type="nucleotide sequence ID" value="XM_019481411.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PB60"/>
    <dbReference type="STRING" id="8496.A0A151PB60"/>
    <dbReference type="GeneID" id="102559510"/>
    <dbReference type="KEGG" id="amj:102559510"/>
    <dbReference type="CTD" id="84869"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PB60"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000285">
        <property type="entry name" value="Carbonyl reductase family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="14">
        <location>
            <begin position="3"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO46220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="237" mass="25367" checksum="9733C83DCB543C8D" modified="2016-06-08" version="1">MAKVCAIFGGSRGIGKGVAQLLVQKGYRLAIIARNLEVAQTTADHLGAGHLALSCDVAKEQDVQNTFEEMERNLGPINYLVNAAGINRDGLLLRTKTEDMISQIHTNLLGTMLTCKAAVRSMIQRQGGAIVNIGSIVGLKGNSGQSVYSASKAGLVGFSRSLAKEVARKKIRVNMVAPGFVRTVMTAHLKEEQMTKTIPLGRFGEPHEVAQAVIFLLESPYVTGHILFVDGGLQLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBV1</accession>
    <name>A0A151PBV1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NOL8</name>
        <name evidence="12" type="ORF">Y1Q_0006962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the interaction is RNA-dependent. Interacts with DDX47; the interaction is RNA-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000504">
        <property type="protein sequence ID" value="KYO46409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBV1"/>
    <dbReference type="STRING" id="8496.A0A151PBV1"/>
    <dbReference type="eggNOG" id="KOG4365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000346">
        <property type="entry name" value="Nucleolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="909"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO46409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1121" mass="128406" checksum="ADDBD78CD7190D6C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PC35</accession>
    <name>A0A151PC35_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Unconventional myosin-Id</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0018382</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PC35"/>
    <dbReference type="STRING" id="8496.A0A151PC35"/>
    <dbReference type="KEGG" id="amj:102558136"/>
    <dbReference type="eggNOG" id="KOG0164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000003">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000007">
        <property type="entry name" value="unconventional myosin-Id"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000009">
        <property type="entry name" value="Unconventional myosin-Id"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF417">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 19" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="15 19" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14 19" id="KW-0518">Myosin</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="9"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="21">
        <location>
            <begin position="812"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="19">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO46612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1006" mass="116258" checksum="EBDEBD639EE12417" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PD41</accession>
    <name>A0A151PD41_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Receptor-type tyrosine-protein phosphatase-like N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PTPRN</name>
        <name evidence="12" type="ORF">Y1Q_0014496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PD41"/>
    <dbReference type="STRING" id="8496.A0A151PD41"/>
    <dbReference type="eggNOG" id="KOG0793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035773">
        <property type="term" value="P:insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14610">
        <property type="entry name" value="R-PTP-N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000017">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase-like N isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF5">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="152"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="331"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO46928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="422" mass="47690" checksum="B408453707B6CCB3" modified="2016-06-08" version="1">MGEKSKLRHLPQQAEEEDSTKFIVLTLLSITCIIGVLVASGVIYCLRHQSHHKLKEKLSTLGTDASSDATAAYQELCRQRMAVKSSDRPEPLHTSRINSVSSQFSDGPIPSPSARSSTSSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNVATIGQKEENIQKNRSETVVPYDHSRIFLKAENSHDNSDYINASPIMDHDPRNPAYIAAQGPLPATVADFWQMVWENGCVVIVMLTPLTENGVKQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWNDQKAPASTRSLLDFRRKVNKCYRGRSCPVIVHCSDGAGRSGTYILIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEV3</accession>
    <name>A0A151PEV3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEV3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO47568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="83" mass="9391" checksum="1B8D1D7E695F6A46" modified="2016-06-08" version="1">MARSRAPGKILLEKECPLKSSLQHARTPPALSYEESFFIKRSVIISGVKRSYRGRCESLNPRIQFLLSLLVDGLQSLSMLQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PEW3</accession>
    <name>A0A151PEW3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CCHC-type and RNA-binding motif-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">U11/U12 small nuclear ribonucleoprotein 31 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZCRB1</name>
        <name evidence="17" type="ORF">Y1Q_0019739</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PEW3"/>
    <dbReference type="STRING" id="8496.A0A151PEW3"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12393">
        <property type="entry name" value="RRM_ZCRB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000233">
        <property type="entry name" value="Zinc finger CCHC-type and RNA-binding motif-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000009">
        <property type="entry name" value="Zinc finger CCHC-type and RNA-binding motif-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044598">
        <property type="entry name" value="ZCRB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034219">
        <property type="entry name" value="ZCRB1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46259:SF1">
        <property type="entry name" value="ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="16">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="149"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO47647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="243" mass="27542" checksum="CFEF47B01F2754C3" modified="2016-06-08" version="1">MPLSVLAYPGRLPLNPYGQVTQEAARKMSGGLAPSKSTVYVSNLPFALTNNDLYRIFSKYGKVVKVTIMKDKDTRKSKGVAFILFLDKESAQNCSRALNNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGEAGHLSYACPKNMLGEREPPKKKEKKKRKKVVEPEEIEEEEESEDEGEDPSLDSLSQAIAFQQAKIEEEQQRWKQPTGEPSTSDDSKRPRIKKSAYFSDEEELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFE7</accession>
    <name>A0A151PFE7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CCR4-NOT transcription complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CCR4-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CNOT2</name>
        <name evidence="18" type="ORF">Y1Q_0019833</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFE7"/>
    <dbReference type="STRING" id="8496.A0A151PFE7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000001">
        <property type="entry name" value="Putative CCR4-NOT transcription complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="17">
        <location>
            <begin position="418"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO47763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="561" mass="62119" checksum="AB5F91A5D245A94E" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFI4</accession>
    <name>A0A151PFI4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MON2</name>
        <name evidence="10" type="ORF">Y1Q_0019780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PFI4"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="7">
        <location>
            <begin position="212"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HDS" evidence="6">
        <location>
            <begin position="848"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="8">
        <location>
            <begin position="931"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO47694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1727" mass="191151" checksum="889CB34A1D202341" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFT9</accession>
    <name>A0A151PFT9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanidinoacetate N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GAMT</name>
        <name evidence="8" type="ORF">Y1Q_0005847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03000375">
        <property type="protein sequence ID" value="KYO47869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFT9"/>
    <dbReference type="STRING" id="8496.A0A151PFT9"/>
    <dbReference type="eggNOG" id="KOG1709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00104">
        <property type="reaction ID" value="UER00580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030731">
        <property type="term" value="F:guanidinoacetate N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006601">
        <property type="term" value="P:creatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000096">
        <property type="entry name" value="Guanidinoacetate N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016550">
        <property type="entry name" value="GuanidinoAc_N-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009285">
        <property type="entry name" value="GAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="7">
        <location>
            <begin position="12"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>guanidinoacetate</name>
            <dbReference type="ChEBI" id="CHEBI:57742"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>guanidinoacetate</name>
            <dbReference type="ChEBI" id="CHEBI:57742"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>guanidinoacetate</name>
            <dbReference type="ChEBI" id="CHEBI:57742"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>guanidinoacetate</name>
            <dbReference type="ChEBI" id="CHEBI:57742"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR009285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO47869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="228" mass="25756" checksum="202486C4686A0F8C" modified="2016-06-08" version="1">MSSSEAASPIFRQGENCKPSWTEAEAGYNQTDTHLKILGKPVMERWETPYMHSLATVAASKGGRVLEVGFGMAIAASKVEEFNIEEHWIVECNEGVFKRLEEWAKKQPHKVVPLRGLWEDVVPMLPDGLFDGILYDTYPLSAETWHTHQFHFIKSHAFRLLKPGGVLTYCNLTSWGELLKTKYTDIEKMFEETQVGHLVEAGFKRENISTAVMDLTPPQDCSTLEIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFX1</accession>
    <name>A0A151PFX1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin conjugation factor E4 A</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UBE4A</name>
        <name evidence="13" type="ORF">Y1Q_0017414</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03000337">
        <property type="protein sequence ID" value="KYO47903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059575811.1">
        <property type="nucleotide sequence ID" value="XM_059719828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFX1"/>
    <dbReference type="STRING" id="8496.A0A151PFX1"/>
    <dbReference type="GeneID" id="102568388"/>
    <dbReference type="KEGG" id="amj:102568388"/>
    <dbReference type="CTD" id="9354"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF16">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO47903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123287" checksum="1B263365AA2D75C8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PG18</accession>
    <name>A0A151PG18_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0012748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000280">
        <property type="protein sequence ID" value="KYO47949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PG18"/>
    <dbReference type="STRING" id="8496.A0A151PG18"/>
    <dbReference type="eggNOG" id="ENOG502QVH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF156">
        <property type="entry name" value="OLFACTORY RECEPTOR 52R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO47949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="131" mass="14803" checksum="8699FE7D6F8B6D15" modified="2016-06-08" version="1">MPVVKLVCGDARANDVYGLFVAFLVGGFDVLVISVSYSMILRTVMRLPSTETRLKAVSTCTSHTCVILALYVPVLFTFLTHQFGHNIPHHVHTMVANLYLLVPPVLNPIVYGVRTKQIWDRVNRLFHPKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGW0</accession>
    <name>A0A151PGW0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transcription factor HIVEP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HIVEP3</name>
        <name evidence="14" type="ORF">Y1Q_0001938</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000257">
        <property type="protein sequence ID" value="KYO48134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGW0"/>
    <dbReference type="STRING" id="8496.A0A151PGW0"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000033">
        <property type="entry name" value="Immunodeficiency virus type I enhancer binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000083">
        <property type="entry name" value="Immunodeficiency virus type I enhancer binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034729">
        <property type="entry name" value="Znf_CCHC_HIVEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR HIVEP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51811">
        <property type="entry name" value="ZF_CCHC_HIVEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC HIVEP-type" evidence="13">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="783"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="828"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO48134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1103" mass="122691" checksum="C422A4E2B61D1765" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHG7</accession>
    <name>A0A151PHG7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ALG2</name>
        <name evidence="9" type="ORF">Y1Q_0022643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000190">
        <property type="protein sequence ID" value="KYO48443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHG7"/>
    <dbReference type="STRING" id="8496.A0A151PHG7"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO48443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="162" mass="18340" checksum="E98C33286162E51A" modified="2016-06-08" version="1">MLYVALYALLRAPPPDIFVCDQVSACIPVLRLARNRKKVLFYCHFPDQLLTKRESLLKRIYRAPLDWLEEYTTGMADCIVVNSEFTANVFADTFKSLSHIKPDVLYPSLTVSAFESIVPVEIANPAGQIQPKFLDPWGALPDIEWPCALDQVKWDLGSNPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHX5</accession>
    <name>A0A151PHX5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM151B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM151B</name>
        <name evidence="3" type="ORF">Y1Q_0004040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the menorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHX5"/>
    <dbReference type="STRING" id="8496.A0A151PHX5"/>
    <dbReference type="eggNOG" id="KOG3748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019356">
        <property type="entry name" value="Menorin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184">
        <property type="entry name" value="MENORIN (DENDRITIC BRANCHING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184:SF3">
        <property type="entry name" value="PROTEIN FAM151B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10223">
        <property type="entry name" value="Menorin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Menorin-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO48639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="185" mass="20967" checksum="E1627492983A5E14" modified="2016-06-08" version="1">MPASVFLPGCCSFGLLHLPAVQPSVELLESIKLHLKRPVWINADILPGPNGSNAVVDAKFFLDIVTSFFPDVTLSLGWTTGCQLQRCKEGYSWAMVKEMAEICNALTQPITFPVRAALVWQSKSELLWLLQQSERYSLTVWTGKQDQYSTEDLLHIRENFDKSRVYYDILEPQNSEFKKAIGIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PI18</accession>
    <name>A0A151PI18_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Versican core protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Chondroitin sulfate proteoglycan core protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Large fibroblast proteoglycan</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">PG-M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">VCAN</name>
        <name evidence="31" type="ORF">Y1Q_0004056</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Interphotoreceptor matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151PI18"/>
    <dbReference type="eggNOG" id="ENOG502QRBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033165">
        <property type="term" value="C:interphotoreceptor matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002052">
        <property type="term" value="P:positive regulation of neuroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03588">
        <property type="entry name" value="CLECT_CSPGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03517">
        <property type="entry name" value="Link_domain_CSPGs_modules_1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03520">
        <property type="entry name" value="Link_domain_CSPGs_modules_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000011">
        <property type="entry name" value="Aggrecan core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000002">
        <property type="entry name" value="Hyaluronan proteoglycan link protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000003">
        <property type="entry name" value="Versican core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000003">
        <property type="entry name" value="Versican core protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000361">
        <property type="entry name" value="versican core protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033987">
        <property type="entry name" value="CSPG_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050691">
        <property type="entry name" value="Hyaluronan_bind_Proteoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804">
        <property type="entry name" value="AGGRECAN/VERSICAN PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22804:SF6">
        <property type="entry name" value="VERSICAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
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        <property type="entry name" value="V-set"/>
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        <property type="entry name" value="LINKMODULE"/>
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        <property type="entry name" value="EGF/Laminin"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 22" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0373">Hyaluronic acid</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 23" id="KW-0768">Sushi</keyword>
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        <location>
            <begin position="33"/>
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        </location>
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        <location>
            <begin position="169"/>
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    <feature type="domain" description="Link" evidence="30">
        <location>
            <begin position="270"/>
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            <begin position="3356"/>
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            <begin position="3405"/>
            <end position="3519"/>
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    </feature>
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        <location>
            <begin position="3523"/>
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        <location>
            <begin position="429"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="847"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1269"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1503"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1782"/>
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    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="2251"/>
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            <begin position="2545"/>
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    <feature type="region of interest" description="Disordered" evidence="25">
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            <begin position="2811"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
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            <begin position="2896"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="3075"/>
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            <begin position="429"/>
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        </location>
    </feature>
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        <location>
            <begin position="453"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="470"/>
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            <begin position="2553"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="3090"/>
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        <location>
            <begin position="215"/>
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            <begin position="313"/>
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    <feature type="disulfide bond" evidence="22">
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            <begin position="3382"/>
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            <begin position="3525"/>
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    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="3554"/>
            <end position="3581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004593"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022974"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023290"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044099"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044266"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50923"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KYO48658.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="3626" mass="395503" checksum="A47453C6AAE3C4DD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LY71</accession>
    <name>A0A151LY71_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Deoxyguanosine kinase, mitochondrial isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DGUOK</name>
        <name evidence="13" type="ORF">Y1Q_0007681</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxycytidine + a ribonucleoside 5'-triphosphate = dCMP + a ribonucleoside 5'-diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="2.7.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyguanosine + ATP = dGMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19201"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57673"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.113"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007073">
        <property type="protein sequence ID" value="KYO17201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151LY71"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004136">
        <property type="term" value="F:deoxyadenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004137">
        <property type="term" value="F:deoxycytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004138">
        <property type="term" value="F:deoxyguanosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000461">
        <property type="entry name" value="Deoxycytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF8">
        <property type="entry name" value="DEOXYGUANOSINE KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="12">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="18"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="176"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO17201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="251" mass="29499" checksum="6247FAE710AE2991" modified="2016-06-08" version="1">MRQLRXXXXAGPRLAIEGNIAVGKSTFVRLLGKAFPEWCVGTEPVAKWQKVQASKPNEQVSSSQSFGNLLQMIYQEPARWSYTFQTYSCMTRLKAQLEPLPEKLLKSQDPVQIFERSVYSDRYVFAKNQFEIGHLSEIEWTIYQDWHTFLVQEFGDRIALHGFLYLQASPEKCLERLHRRARAEEKDIRLEYLEQLHAQHENWLVNKSAEVHFENLRNAPVLMLDVNQDFEHNPSVQEELMRKVKTFIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZW9</accession>
    <name>A0A151LZW9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane protein GPR155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GPR155</name>
        <name evidence="4" type="ORF">Y1Q_0011494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO17825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QQ69">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04443">
        <property type="entry name" value="DEP_GPR155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037368">
        <property type="entry name" value="GPR155_DEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051832">
        <property type="entry name" value="mTOR-Rac_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829">
        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="664"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO17825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="734" mass="82421" checksum="0B39923264570A57" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M0H9</accession>
    <name>A0A151M0H9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KIF5B</name>
        <name evidence="14" type="ORF">Y1Q_0011630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M0H9"/>
    <dbReference type="STRING" id="8496.A0A151M0H9"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098957">
        <property type="term" value="P:anterograde axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007292">
        <property type="term" value="P:female gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000067">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF70">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM 5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="906"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="394"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="571"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO18027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="939" mass="107101" checksum="77E384FF692EAF61" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M137</accession>
    <name>A0A151M137_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-related protein M-Ras</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRAS</name>
        <name evidence="11" type="ORF">Y1Q_0011780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006853">
        <property type="protein sequence ID" value="KYO18223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M137"/>
    <dbReference type="STRING" id="8496.A0A151M137"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04145">
        <property type="entry name" value="M_R_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO18223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="237" mass="26944" checksum="578E63040C87622B" modified="2016-06-08" version="1">MDSVRVLQKMRKTVSSRGSARRGVQPAGNMATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDGQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGREMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQRKKKKTKWRGDRATGSHRAQCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1M5</accession>
    <name>A0A151M1M5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1M5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="7994" checksum="9552EC5C32B3BD9C" modified="2016-06-08" version="1">MAFIEETGKQLNEKGFTSGRHCWDIEVEYTGDKCGSSQSLCSGKEASFLILRGSGLCRSRRTHGKGPGAGKNAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M223</accession>
    <name>A0A151M223_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M223"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7651" checksum="718F302196F1E857" modified="2016-06-08" version="1">MVQGSKSTAMTLCRRQICDASLFSCRKVTRLPFGPLQRNGPKHPTHCSRNILPCAERKPPLIQGILQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M265</accession>
    <name>A0A151M265_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nutritionally-regulated adipose and cardiac enriched protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0014839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M265"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028114">
        <property type="entry name" value="DUF4658"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15555">
        <property type="entry name" value="DUF4658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO18582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="214" mass="24313" checksum="6D16B0AC5AE8E538" modified="2016-06-08" version="1">MLNIKVYILCCSRTLEGTVRLYIRRVQVVKLKSRAFRRNGSNAVMRFLNSEDLFMLECKYPDVLRPGKAGRPDTTSVKTLQKAAGSGSSDHFRSPEAADVLQHEEEPAGTPMHRREMTNCSNCPPSILRKRPPVNQAVGEKRKSERRVRFQEPEEIHEHAQRLPAYPLHGGEREENSFRLGVFPAVSTWLPMTVHPLVCLRSCGFCSVSHSSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2J1</accession>
    <name>A0A151M2J1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0009141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2J1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO18691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="114" mass="13312" checksum="EC62CA1879C6193B" modified="2016-06-08" version="1">MQQLYGSVGREVQAGKDTVSQKRWNNSHFRLLRACREKTVKRWGCLGLKRKIEAPRELGRENSLLCCLGHWHSNPLLFSLSWELIKKELSEVILTFIKSCSEHFLRKVSQKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3R8</accession>
    <name>A0A151M3R8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3R8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584675" evidence="1">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="137" mass="14800" checksum="B842609D06927705" modified="2016-06-08" version="1">MSWKTRHTSWMAFMAKLVGVVAVTAKGNQLHDDDGHMLLQSEGWLHANILAQDVKLHLVDDIHEGGPAHAEYLKPLFSIPGAQDDWLSPIGASFMGPEPVFDGLVEPEHPSLHGILDGLDGLILVGHTKASGPVQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M533</accession>
    <name>A0A151M533_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">ATP-binding cassette sub-family D member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">70 kDa peroxisomal membrane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">ABCD3</name>
        <name evidence="35" type="ORF">Y1Q_0007507</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="28">Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes. Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:77016"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:74298"/>
            <dbReference type="ChEBI" id="CHEBI:77016"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67701"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58562"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:67709"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67712"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58562"/>
            <dbReference type="ChEBI" id="CHEBI:73862"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:67713"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O = 2,6,10,14-tetramethylpentadecanoate(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:77268"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:67689"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a long-chain fatty acid(in) + ATP + H2O = a long-chain fatty acid(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:67685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:67681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:67081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:67073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>hexadecanedioate(in) + ATP + H2O = hexadecanedioate(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:76276"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hexadecanedioyl-CoA + H2O = hexadecanedioate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:76276"/>
            <dbReference type="ChEBI" id="CHEBI:77085"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:67697"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pristanoyl-CoA + H2O = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40415"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77250"/>
            <dbReference type="ChEBI" id="CHEBI:77268"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:40416"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="29">Homodimers. Can form heterodimers with ABCD1 and ABCD2. Dimerization is necessary to form an active transporter. Interacts with PEX19; mediates the targeting of ABCD3 to peroxisomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006584">
        <property type="protein sequence ID" value="KYO19581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014455232.1">
        <property type="nucleotide sequence ID" value="XM_014599746.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019334611.1">
        <property type="nucleotide sequence ID" value="XM_019479066.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M533"/>
    <dbReference type="STRING" id="8496.A0A151M533"/>
    <dbReference type="GeneID" id="102572903"/>
    <dbReference type="KEGG" id="amj:102572903"/>
    <dbReference type="CTD" id="5825"/>
    <dbReference type="eggNOG" id="KOG0060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000036">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005283">
        <property type="entry name" value="FA_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00954">
        <property type="entry name" value="3a01203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF62">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 35" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 32" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="34">
        <location>
            <begin position="110"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="33">
        <location>
            <begin position="436"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00053192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00065720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00070602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00076825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KYO19581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="661" mass="75969" checksum="B1261915EFE1718C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6L1</accession>
    <name>A0A151M6L1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-hydroxytryptamine receptor 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serotonin receptor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HTR4</name>
        <name evidence="20" type="ORF">Y1Q_0010721</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6L1"/>
    <dbReference type="STRING" id="8496.A0A151M6L1"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032098">
        <property type="term" value="P:regulation of appetite"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15056">
        <property type="entry name" value="7tmA_5-HT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000046">
        <property type="entry name" value="5-hydroxytryptamine receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001520">
        <property type="entry name" value="5HT4_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF66">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01059">
        <property type="entry name" value="5HT4RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="73"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO20146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="424" mass="48282" checksum="9C1F5AA70F44F047" modified="2016-06-08" version="1">MIVARVSAANQVTLPWWTGPGFFCGHWTSSYLCLLPVMEELDVNVSSSERFNVAEKIALLTFISAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVENNWIYGEMFCLVRTSLDVLLTTASILHLCCIALDRYYAICCQPLVYRNKMTPIRIAVMLGGCWVIPTFISFLPIMQGWNSIGIIDLIQQRQFNKASNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYITAREHARQIRILQRAGAPTDGRQHHPDQHSTHRMKTETKAAKTLCIIMGCFCLCWAPFFITNIVDPFINYTVPEQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCGDERYRRPSILGPAVPCSTTTINGSTHVLRYTVLHNGHHQEHEKLPIHNDPESQESCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M9A7</accession>
    <name>A0A151M9A7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M9A7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="120" mass="13669" checksum="82292472DE359FF9" modified="2016-06-08" version="1">MGGEKAGKGAGRICSFKYLALHLTLVKVKLERKDNTSGLPTFSWKPIPQNKDFPSLMRAHLQELESHLAFAFFILVSPKDIFVLHHNLFELHFLPMWKPAYTLHVLITGKTDPNQSPIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151ME34</accession>
    <name>A0A151ME34_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tissue factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Coagulation factor III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">IFNAR2-1</name>
        <name evidence="18" type="ORF">Y1Q_0003265</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tissue factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151ME34"/>
    <dbReference type="STRING" id="8496.A0A151ME34"/>
    <dbReference type="eggNOG" id="ENOG502S60E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042018">
        <property type="term" value="F:interleukin-22 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001187">
        <property type="entry name" value="Tissue_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF84">
        <property type="entry name" value="INTERFERON ALPHA_BETA RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01108">
        <property type="entry name" value="Tissue_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00346">
        <property type="entry name" value="TISSUEFACTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon/interleukin receptor" evidence="17">
        <location>
            <begin position="127"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO22777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="313" mass="34893" checksum="5FEE79222E3A8042" modified="2016-06-08" version="1">MMELTGPLHFYQLVYVGILATTSYSWPASVINPQFNVTMTSQNFQHILSWEAGSNTTVPTYYQVKYSSFRSGEFQIAEECSNITHLFCDLSEYFTDEHENYEAMVQGFTGSKVFTSFTCCLIPYLYTSLGPPAVNITPYPSSINITIKLPASHLKREGKVLSLIDIYDELNYVITVRRSDAQVLTLKNTTTKEHFATVVEGLYPNANYCVSVAVTAPIHDKSIPSTLKCVITGSISQQGYPAVSITGGVLVALVVCVILFILHIAGIIRLKTKKWPSVLKTTRNLGYSVCEPEPENVSPVQVVFQDIKKKIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFJ6</accession>
    <name>A0A151MFJ6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="15">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Y1Q_0005598</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFJ6"/>
    <dbReference type="STRING" id="8496.A0A151MFJ6"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000008">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585137" description="alpha-1,2-Mannosidase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="18">
        <location>
            <begin position="651"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO23160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="822" mass="91399" checksum="2DD9181382517608" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MG62</accession>
    <name>A0A151MG62_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF 65 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U2 auxiliary factor 65 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">U2AF2</name>
        <name evidence="14" type="ORF">Y1Q_0010071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006198">
        <property type="protein sequence ID" value="KYO23499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QQPY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919:SF2">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919">
        <property type="entry name" value="ZINC FINGER, C3HC4 TYPE (RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="254"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="376"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="HEPN" evidence="13">
        <location>
            <begin position="4557"/>
            <end position="4673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4485"/>
            <end position="4506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4485"/>
            <end position="4497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO23499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="4684" mass="527043" checksum="82A121A2A98D46DC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJW6</accession>
    <name>A0A151MJW6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Collagen alpha-1(VII) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0023706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJW6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22627">
        <property type="entry name" value="Kunitz_collagen_alpha1_VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="427"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO24822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="499" mass="51518" checksum="93122ED9481326AE" modified="2016-06-08" version="1">MGSLWRLPGARGERGDPGPRGEDGRPGLEGDRGPAGLPGNRGERGDKGDVGPMGLKGDKGDTIVVEGQAGARGNKGEPGDRGLKGNEGDKGDKGDQGLPGEKGVKGQQGDKGSTGFPGARGPDGQKGEVGESGEPGEPGQPGKDGIPGTRGEKGDMGPMGIRGPKGDRGMKGACGHDGSKGEKGESGMPGRPGLPGRKGEPGELGMSGAPGIPGKEGLMGPKGDRGFDGQQGAKGDQGEKGDRGAPGIIGASGPRGSDGAPGPPGPPGNVGPKGPEGIQGQKGERGPSGESVAGTRGVPGIPGERGEQGNPGLEGPRGEKGEPGMMEEEIREFVRQEMSQHCACGGRYPSSGSRPLPNYPSTQPFPSVKAQLVPVLKLSHAEEEGQETRIVVDSDDPEYEQMYIEDYGEDVDAEDTEHPMLSDANPCSLPLDEGTCSRFTLRWYYNQRVAECRPFIYSGCGGNLNRFYAKEDCDRQCRHHVDTDVYLAGGSMSEGKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK35</accession>
    <name>A0A151MK35_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Y1Q_0023751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK35"/>
    <dbReference type="STRING" id="8496.A0A151MK35"/>
    <dbReference type="KEGG" id="amj:102569760"/>
    <dbReference type="eggNOG" id="KOG3528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75502at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06687">
        <property type="entry name" value="PDZ1_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06681">
        <property type="entry name" value="PDZ2_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06684">
        <property type="entry name" value="PDZ3_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06686">
        <property type="entry name" value="PDZ4_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06682">
        <property type="entry name" value="PDZ5_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06683">
        <property type="entry name" value="PDZ6_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06685">
        <property type="entry name" value="PDZ7_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000021">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000022">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000023">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000025">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000031">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000034">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF4">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="148"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="248"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="457"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="558"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="657"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="970"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="815"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO24876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1112" mass="121004" checksum="D07F2715908D6288" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKB4</accession>
    <name>A0A151MKB4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Caveolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CAV3</name>
        <name evidence="12" type="ORF">Y1Q_0023778</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <location evidence="10">Caveola</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the caveolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006272714.2">
        <property type="nucleotide sequence ID" value="XM_006272652.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKB4"/>
    <dbReference type="STRING" id="8496.A0A151MKB4"/>
    <dbReference type="GeneID" id="102560790"/>
    <dbReference type="KEGG" id="amj:102560790"/>
    <dbReference type="CTD" id="859"/>
    <dbReference type="eggNOG" id="ENOG502RYU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5917823at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070836">
        <property type="term" value="P:caveola assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018361">
        <property type="entry name" value="Caveolin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF16">
        <property type="entry name" value="CAVEOLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01210">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO24909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="151" mass="17249" checksum="45170998FE86BCD7" modified="2016-06-08" version="1">MAEEQSGLEERIIIKDQHTKEIDLVNRDPKHINEDVVKVDFEDVIAEPVGTYSFDGVWKTSYTTFTVSKYWCYRLLSAILGIPLAVIWGFLFALISFCHIWAVVPCIKSYVIEIQCISRIYSLCIHTFCDPLFEALAKICGGIKVALRKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKR6</accession>
    <name>A0A151MKR6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKR6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="108" mass="11897" checksum="3087D2315DED79FF" modified="2016-06-08" version="1">MAGFAASWPFHIHWKPDQGKPLRGMNTLCSAQQEPKMTGVLFWELRSMHTGAEGSQPLGGSALGAQYFIPFLSVGQPFHGHSAAFGTFSEKETPKWNVFHSERKHGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKS7</accession>
    <name>A0A151MKS7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">cAMP-dependent protein kinase type II-alpha regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PRKAR2A</name>
        <name evidence="16" type="ORF">Y1Q_0023881</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO25053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKS7"/>
    <dbReference type="STRING" id="8496.A0A151MKS7"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000017">
        <property type="entry name" value="cAMP-dependent protein kinase type II regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000027">
        <property type="entry name" value="Protein kinase cAMP-dependent type II regulatory subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0114">cAMP</keyword>
    <keyword evidence="7 14" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="91"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="213"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO25053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="355" mass="40251" checksum="3FDBCF7916679363" modified="2016-06-08" version="1">MIKTVTGLQCSAENMLGTRGPFNPVEKCTTKPCGWKLKPAPVINRFNRRVSVCAEAFNPDEEEEDTEPRVVHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERKVKPQEHVIDQGDDGDNFYVIERGLYDIFVTRDNQSRCVGRYDNHGSFGELALMYNTPRAATIVATTEGSLWGLDRVTFRRIILKNNAKKRKTYELFIESVPLLKSLEVSERMKIADVIGEKIYQDGDRIISQGDKADSFYIVESGEVKILIKSKTMTSKDANQEVEIARCHKGQYFGELALVTNKPRAASAYAVGEVKCLVMDVQAFERLLGPCMDIMKRNITHYEEQLVALFGSSMDLMDPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MKZ4</accession>
    <name>A0A151MKZ4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable splicing factor YJU2B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Coiled-coil domain-containing protein 130</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CCDC130</name>
        <name evidence="7" type="ORF">Y1Q_0009017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005909">
        <property type="protein sequence ID" value="KYO25231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKZ4"/>
    <dbReference type="STRING" id="8496.A0A151MKZ4"/>
    <dbReference type="GeneID" id="102564581"/>
    <dbReference type="KEGG" id="amj:102564581"/>
    <dbReference type="CTD" id="81576"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MKZ4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO25231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="340" mass="38442" checksum="124C88BB5FF52283" modified="2016-06-08" version="1">MGERKGVNKYYPPDFDPAKHGSLNKYRHSHPLRERARKLSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGAQRKEERWDPQDNEQVLATEHEEKKKLETDAMYRLEHGAADQGKLQRALPTLSNIQEAQSAWKDDFALNSMLRRKFREEKKVLQEEEEKDQALQAKANLSIPLVREAEEDRRLATLLTYRSPDSYEDKQKQKRTEISSRSWFPSAKAGDALKLPGLGTKTSSSPAPCDHLGIVRRRPTDVSRGLASLGDATETPCALPTSPTAGPSGPPHSLVPDYSGSGSDSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MM76</accession>
    <name>A0A151MM76_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-interacting protein kinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HIPK4</name>
        <name evidence="9" type="ORF">Y1Q_0010029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005718">
        <property type="protein sequence ID" value="KYO25626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MM76"/>
    <dbReference type="STRING" id="8496.A0A151MM76"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF46">
        <property type="entry name" value="HOMEODOMAIN-INTERACTING PROTEIN KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO25626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="514" mass="56467" checksum="2F3CD412470875CE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMC1</accession>
    <name>A0A151MMC1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 127 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM127-1</name>
        <name evidence="3" type="ORF">Y1Q_0001830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005679">
        <property type="protein sequence ID" value="KYO25672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MMC1"/>
    <dbReference type="eggNOG" id="ENOG502QTCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033331">
        <property type="entry name" value="TMEM127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046795">
        <property type="entry name" value="TMEM127_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28358">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28358:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20517">
        <property type="entry name" value="TMEM127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 127 transmembrane region" evidence="2">
        <location>
            <begin position="88"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO25672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="253" mass="27562" checksum="8E323AAF79CC0BB1" modified="2016-06-08" version="1">MYAAAAGAAGPGGRGXXXXXXXXXXALPKQPERSLASALPGALSITALCTALAEPAWLRLHGGVCARQELGVADVLGCVEPALLRDYCMNAQTVLLLRVIAAFCFLGIICSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFCYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENEAYPAEPSMISFQVLHRRWMDRRRQELALSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MMS2</accession>
    <name>A0A151MMS2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="20">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0023650</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="20"/>
    <dbReference type="EMBL" id="AKHW03005669">
        <property type="protein sequence ID" value="KYO25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MMS2"/>
    <dbReference type="STRING" id="8496.A0A151MMS2"/>
    <dbReference type="eggNOG" id="KOG0197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05067">
        <property type="entry name" value="PTKc_Lck_Blk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10362">
        <property type="entry name" value="SH2_Src_Lck"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12005">
        <property type="entry name" value="SH3_Lck"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000553">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000152">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000036">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000077">
        <property type="entry name" value="Tyrosine-protein kinase Lck"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035850">
        <property type="entry name" value="Lck_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035749">
        <property type="entry name" value="Lck_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="9 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 20" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="21">
        <location>
            <begin position="163"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="281"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="545" mass="62578" checksum="4999BD65F67B9C29" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNM7</accession>
    <name>A0A151MNM7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein SNAI2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein snail homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SNAI2</name>
        <name evidence="18" type="ORF">Y1Q_0003882</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006272860.1">
        <property type="nucleotide sequence ID" value="XM_006272798.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNM7"/>
    <dbReference type="STRING" id="8496.A0A151MNM7"/>
    <dbReference type="GeneID" id="102557960"/>
    <dbReference type="KEGG" id="amj:102557960"/>
    <dbReference type="CTD" id="6591"/>
    <dbReference type="eggNOG" id="KOG2462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MNM7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000085">
        <property type="entry name" value="Snail zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000942">
        <property type="entry name" value="Snail zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001114">
        <property type="entry name" value="Zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF42">
        <property type="entry name" value="ZINC FINGER PROTEIN SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO26134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="268" mass="30063" checksum="12732CBA94A8ECDA" modified="2016-06-08" version="1">MPRSFLVKKHFNSSKKPNYSELDTHTVIISPYLYESYPVPIIPQPEILSSVSYNPITVWTTTGLLPSPLPNDLSPLSGYPSSLGRVSPPPPSDTSSKDHSGSESPISDEEERIQSKLSDPHAIEAEKFQCSLCNKTYSTFSGLAKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR78</accession>
    <name>A0A151MR78_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005442">
        <property type="protein sequence ID" value="KYO27046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR78"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="145" mass="16541" checksum="DD509DBF20BFFB97" modified="2016-06-08" version="1">MDWTWLLANLTTKAEEQLAEKWVCYMEDVVCEFWDRLLALKERHLEAQERQAAMLARAMEVTGEWWVLDTILALAITFVPLTAQPPRLQYHLPPGSCPPPSIKPHRSPDARVEAREKAGARDSGAGSGARRGKLSSSEEEWWSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR79</accession>
    <name>A0A151MR79_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005442">
        <property type="protein sequence ID" value="KYO27044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR79"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO27044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7848" checksum="AC4BFB8C4B167A6B" modified="2016-06-08" version="1">MYGNWDKEAEIEELHLLDHLPSQDKDKLLVALKNFETVFSNKPGTFAQGRSLQELALPQEFSLQSCNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRM7</accession>
    <name>A0A151MRM7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0011156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005250">
        <property type="protein sequence ID" value="KYO27195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRM7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO27195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="154" mass="17548" checksum="726273B1D44ACA02" modified="2016-06-08" version="1">MPRARGWMGHDARGGKFNNAPPTPLPAQCGLPEAAVQEQELVRQDQAKLKDQRRSHEEHVRQLEEMLQLEQKVLLEELDQIEAQTLWVQGQEGGRTMPRHAMPEPRAERGLTRVFPQEELLRERFQEESSGTEGELHQLQEESPAMSRPGSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSM6</accession>
    <name>A0A151MSM6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0003670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MTSS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSM6"/>
    <dbReference type="STRING" id="8496.A0A151MSM6"/>
    <dbReference type="eggNOG" id="ENOG502QRG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10061327at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07643">
        <property type="entry name" value="I-BAR_IMD_MIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22060">
        <property type="entry name" value="WH2_MTSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000010">
        <property type="entry name" value="Metastasis suppressor 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF8">
        <property type="entry name" value="PROTEIN MTSS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="658"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO27515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="712" mass="77486" checksum="7839ED477F6E1FDF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSQ3</accession>
    <name>A0A151MSQ3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein NDRG4 isoform C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NDRG4</name>
        <name evidence="4" type="ORF">Y1Q_0003660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NDRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005169">
        <property type="protein sequence ID" value="KYO27499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019352797.1">
        <property type="nucleotide sequence ID" value="XM_019497252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSQ3"/>
    <dbReference type="GeneID" id="102566160"/>
    <dbReference type="CTD" id="65009"/>
    <dbReference type="eggNOG" id="KOG2931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000009">
        <property type="entry name" value="NDRG family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO27499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="403" mass="44348" checksum="4AE1484089FA66B5" modified="2016-06-08" version="1">MKVLGHKIELLTGLLLQEVTMAGLHELRFTEEKPLLRGQDTELENSDAFLSAVDTDWKEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNYEDMQEITKHFVVCHVDAPGQQAGASQFPQGYQYPSMDQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLTSSLPDTVLSHLFSQEELVNNTELVQSYRQQISSVVNQYNLQLFWNMYNGRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTNTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAYLKDRRLSGGAVPSASMTRLARSRTASLTSASSVDGARPRACTHSESSEAMGQINHTMEVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTE6</accession>
    <name>A0A151MTE6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Syntaxin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">STX5</name>
        <name evidence="10" type="ORF">Y1Q_0012898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005097">
        <property type="protein sequence ID" value="KYO27785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTE6"/>
    <dbReference type="STRING" id="8496.A0A151MTE6"/>
    <dbReference type="eggNOG" id="KOG0812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000005">
        <property type="entry name" value="syntaxin-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO27785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="243" mass="27453" checksum="F0414E1646A73FBC" modified="2016-06-08" version="1">MSCRDRTQEFLSACKSLQSRQNGLQLSKPVSSAVRQRSEFTLIAKRIGKDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQEFVRAKGGLSGRHVQTHSNTVVVSLQSKLASMSNDFKSVLEVRTENLKQQRSRREQFSRAPVSTSNLGGSTVLQDESRRASGDVAIDMDSRTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEETIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTI8</accession>
    <name>A0A151MTI8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TUBB6</name>
        <name evidence="14" type="ORF">Y1Q_0013008</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005078">
        <property type="protein sequence ID" value="KYO27809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTI8"/>
    <dbReference type="STRING" id="8496.A0A151MTI8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="174"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO27809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="345" mass="38596" checksum="B5D92ED7F3E5D01B" modified="2016-06-08" version="1">MDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKIKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUB0</accession>
    <name>A0A151MUB0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CABP4</name>
        <name evidence="6" type="ORF">Y1Q_0005077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005047">
        <property type="protein sequence ID" value="KYO28078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUB0"/>
    <dbReference type="STRING" id="8496.A0A151MUB0"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000069">
        <property type="entry name" value="calcium-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000037">
        <property type="entry name" value="calcium-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043582">
        <property type="entry name" value="CaBP1/2/4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45917">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45917:SF4">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO28078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="240" mass="27014" checksum="DF204185FDAA956C" modified="2016-06-08" version="1">MPRKQPSKAEKDTHKEAEILGKGKVGEVGEKPPKDKEEPKASKSPGSETRSNAHTGHMHKSSKKGHSDPNAAAIKVYSPFLNTVFGKERELSPEEIDELLDAFKEFDTDQDGYISYKDLGPCMRTMGYMPTEMELIEISQHIKMRMGGRVDFEDFVDMMGPKLREETAHMVGVRELKIAFREFDMDGDGEISSMELKDAISALLGEQLKIQEVEEILQDVDLNGDGHVDFDEFVMMLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUW7</accession>
    <name>A0A151MUW7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004968">
        <property type="protein sequence ID" value="KYO28239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUW7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="129" mass="13376" checksum="3FDE77E5E6D8F143" modified="2016-06-08" version="1">MKELVGELGREPAAKPVGEPAGMPLKEPERDPAGMPEKEPVGDPDGTLVKEPVGEPAGTLEKELVGEPAGTSMNEPVGEPAGKLVKELVGELTGKPRRKSTGATGPRVSQSSDRTPGKVTKSSWSVTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVS7</accession>
    <name>A0A151MVS7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004838">
        <property type="protein sequence ID" value="KYO28663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVS7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="82" mass="9510" checksum="108E6485814718E3" modified="2016-06-08" version="1">MQQRLKEKRQELLQGCQKELMGDDSQKQAILEELEQETARKKEAALLVYGKKYKEAMLSANRKALGDAIKKMEQFLLEQVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MW92</accession>
    <name>A0A151MW92_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Insulin-like growth factor-binding protein 3 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM219</name>
        <name evidence="7" type="ORF">Y1Q_0016273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004763">
        <property type="protein sequence ID" value="KYO28772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MW92"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039493">
        <property type="entry name" value="TMEM248/TMEM219"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039587">
        <property type="entry name" value="TMEM248/TMEM219_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002:SF6">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 248-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14940">
        <property type="entry name" value="TMEM219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TMEM248/TMEM219" evidence="6">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO28772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="159" mass="16272" checksum="B9625B9E7D04CF7A" modified="2016-06-08" version="1">MAGGPSPLRQCLVQRPPLVACALGLAALGLALAALGAHVQAHNVRDSEAQDWNALLAAVAELRFCPESGPAPPPTAGTAASASVSVQVSLRFDLPGGPRPNATRFAATVSARRLGLAEPPVPGRRRSRGCQPPTPPRSWSRQAAGVLDCWLLLGAPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MZY0</accession>
    <name>A0A151MZY0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UBX domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UBXN6</name>
        <name evidence="10" type="ORF">Y1Q_0000360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with VCP through the PUB domain (via C-terminus) and VIM motif (via N-terminus); the interaction is direct. Forms a ternary complex with CAV1 and VCP. Interacts with SYVN1. Interacts with HERPUD1. Interacts with VCPKMT. May interact with DERL1. Interacts with PLAA, VCP and YOD1; may form a complex involved in macroautophagy. Interacts with LMAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004368">
        <property type="protein sequence ID" value="KYO30048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014460436.1">
        <property type="nucleotide sequence ID" value="XM_014604950.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MZY0"/>
    <dbReference type="STRING" id="8496.A0A151MZY0"/>
    <dbReference type="GeneID" id="102576810"/>
    <dbReference type="CTD" id="80700"/>
    <dbReference type="eggNOG" id="KOG2699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MZY0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10460">
        <property type="entry name" value="PUB_UBXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16119">
        <property type="entry name" value="UBX_UBXN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000185">
        <property type="entry name" value="UBX domain-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042774">
        <property type="entry name" value="UBXN6_PUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23153:SF38">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23153">
        <property type="entry name" value="UBX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBX" evidence="9">
        <location>
            <begin position="329"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO30048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="439" mass="50110" checksum="99252CE6F5FB374C" modified="2016-06-08" version="1">MRKFFQEIKADLKFKSAGPGQKLAEPPRERVHQEKSKAETKPRHGPTSEAQMAAAAAVARLEQKPKPRLSSSQDVIKSQVRKELMAEAAAYERGPSPDHKDPEAAEEEECAGLSVSGVYFICPLTGATVKKDKREAHIREAILSHSSKDPVAASVMEIHTFNRDREKVKLGVETIAKYLDNIHLHPEEEKYQKIKLQNKVFQERINCLEGVHNFFQAIGFEKKALPVPGQETTEEYYVLKEEVLTKLEDLKDYKDQLLNSEPVRVQLDRQLCIFKPSPQAAQFELPNDFYNLTAEELKREQRLRTEAVEKASMLRTKAMREKEEQREMRKYNYTLLRVRFPDGYILQGTFYAREQVSTLYKFVREALQHDWLPFELLAPGGLKLTDENLAFNECGLVPSALLTLSWDAAVMADIKAAEKEEEAKSHLKPELLSAVQTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0A7</accession>
    <name>A0A151N0A7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stathmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">STMN3</name>
        <name evidence="6" type="ORF">Y1Q_0021187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the stathmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004329">
        <property type="protein sequence ID" value="KYO30115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059569150.1">
        <property type="nucleotide sequence ID" value="XM_059713167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0A7"/>
    <dbReference type="STRING" id="8496.A0A151N0A7"/>
    <dbReference type="GeneID" id="102566639"/>
    <dbReference type="KEGG" id="amj:102566639"/>
    <dbReference type="CTD" id="50861"/>
    <dbReference type="OrthoDB" id="5986631at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030514">
        <property type="entry name" value="Stathmin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF17">
        <property type="entry name" value="STATHMIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002285">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00563">
        <property type="entry name" value="STATHMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01041">
        <property type="entry name" value="STATHMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO30115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="191" mass="22356" checksum="2C7339ADFAA9DEA6" modified="2016-06-08" version="1">MASTVSEVKMEKQPYTQAYKEKMKELSLLSLICSCFHTQPHPNTIYQYGDMEVKQLDKRASGQSFEVILKSPSDLSPESPILSSPPKKKDLSLEELQRRLEAAEERRKTQEAQVLKQLAEKREHEREVLHKALEENNNFSRLAEEKLNYKMELSREIREAHLAALRERLREKELHAAEVRRNKEQREEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1G7</accession>
    <name>A0A151N1G7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Multidrug resistance-associated protein 1</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
            <ecNumber evidence="15">7.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">ATP-binding cassette sub-family C member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Glutathione-S-conjugate-translocating ATPase ABCC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Leukotriene C(4) transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">Y1Q_0008214</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82961"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:60129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:74887"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143093"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38951"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60119"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:38952"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EC" id="7.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N1G7"/>
    <dbReference type="KEGG" id="amj:102573783"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N1G7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034634">
        <property type="term" value="F:glutathione transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000007">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF241">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="963"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1010"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1084"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1111"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1193"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="28">
        <location>
            <begin position="325"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="27">
        <location>
            <begin position="641"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="28">
        <location>
            <begin position="970"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="27">
        <location>
            <begin position="1287"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="906"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="906"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KYO30567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1523" mass="170362" checksum="300CCFCE0F539F50" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N309</accession>
    <name>A0A151N309_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RUN and FYVE domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0016503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N309"/>
    <dbReference type="STRING" id="8496.A0A151N309"/>
    <dbReference type="KEGG" id="amj:102570496"/>
    <dbReference type="OrthoDB" id="9044749at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17682">
        <property type="entry name" value="RUN_RUFY4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753:SF3">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="3">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="175"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="1">
        <location>
            <begin position="304"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO31162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50038" checksum="4BD5ED550270B061" modified="2016-06-08" version="1">MTGREPLLGALKVCILSLKEGNSPYTDASPHLTSFCEILEMILRKGMKQPVLGFRRRDYWHWLEQLPQQDTASRVTPLSIVIERASSCEKVLTAQGRGRYFLRLALNGKLLATAVRQLSQSSKLPEFYDPVTSILGNEDFMEPFLSLMLVVTEMNFSLDLQNSSFLDESWLLPVCVTYETVPCRELGMVLRYLEGRIFVIEMLPESQAEVDEVVLAGDVIDEINGVSLRNAYNGQAGAVLQKLKGKPLHFRLIRWKWHDGGMYKPLLPYLKVLREKVSGFQLQYEHRCKEEKEDRCLQGGRLLYNLRYLGQANVGKYGGKEVLDQGIPTVLEQHLPPQEVLFDVKETEVLIQERTSSKVLLHYPYPEISCVGRRLDNSNLFAFCVAVSPEMPEQSTFACLVFESNSQEECEEIIKRIGGELRHSKTIRLTEVTQRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3N6</accession>
    <name>A0A151N3N6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3N6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO31235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="104" mass="12035" checksum="E79B235F51729170" modified="2016-06-08" version="1">MAEYLPHGLLSASIVSLQPDYGQTFASLRTFFSQWHIREHVKPTVTSIIENEKSIKKGARQRDHLHARQNSHLFLTAGLSGKLPKSPRRRRKGRKNKKHKKRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3X7</accession>
    <name>A0A151N3X7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3X7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO31387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="77" mass="8603" checksum="428C7C0C4FC7855E" modified="2016-06-08" version="1">MLGFLSPPGSYSRQIEPGLWVFPDSAFVAGRPRHGTRDTESRIADQTQSTREMCVDSAGNMRTKGDHRCGGMEWADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N406</accession>
    <name>A0A151N406_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PHD finger protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PHF24</name>
        <name evidence="6" type="ORF">Y1Q_0019578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004083">
        <property type="protein sequence ID" value="KYO31365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N406"/>
    <dbReference type="STRING" id="8496.A0A151N406"/>
    <dbReference type="eggNOG" id="ENOG502QT6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031946">
        <property type="entry name" value="KIAA1045_Zf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46453:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46453">
        <property type="entry name" value="PROTEIN KINASE C-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16744">
        <property type="entry name" value="zf-RING_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KIAA1045 RING finger" evidence="5">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO31365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="366" mass="41466" checksum="22EA045511B9E603" modified="2016-06-08" version="1">MGVLMSRRQTVEQVQKVSLAVSAFKDGLRERPAAKRKGEAVAGPQRGTPEHAVQEVTEDEAAGPSPRPEASANRAAWERLRDGRGVEPEEFDRANRFTPPAFVRPTRELGDDEPPDISLERREQVTNDEMCEICEVWTAESLFPCRVCTRVYHDGCLRRMGYLPQGSATELTETAHTETGWSCYYCDNLNLLLTEEEMYSLMETFRQCHIIPDTCLTLDDFLAYKHLVHKRQFERPMGEAQEERATLQFGALDPDKRGHVEWADFLSHESIQLLQKLRPQNSLLHLLTAKERERARAAFLALPRDPDGRVSQAECRRAQLAWFRKHPPDAPSCNVSISHVGPMSESSPSSASSKSQDKAPEQEEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4X6</accession>
    <name>A0A151N4X6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrator complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">INTS4</name>
        <name evidence="14" type="ORF">Y1Q_0003414</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15. The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to form the Integrator-PP2A (INTAC) complex. INTS4 is part of the RNA endonuclease subcomplex, composed of INTS4, INTS9, INTS11 and inositol hexakisphosphate (InsP6). Interacts with BRAT1; interaction is required for the assembly of the RNA endonuclease subcomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Integrator subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004037">
        <property type="protein sequence ID" value="KYO31848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019349134.1">
        <property type="nucleotide sequence ID" value="XM_019493589.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4X6"/>
    <dbReference type="STRING" id="8496.A0A151N4X6"/>
    <dbReference type="GeneID" id="102569954"/>
    <dbReference type="CTD" id="92105"/>
    <dbReference type="eggNOG" id="KOG2259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18190at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000134">
        <property type="entry name" value="Integrator complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000634">
        <property type="entry name" value="integrator complex subunit 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056235">
        <property type="entry name" value="INTS4_8HBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24493">
        <property type="entry name" value="INTS4_8HBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="INTS4 8 helical bundle" evidence="12">
        <location>
            <begin position="611"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="13">
        <location>
            <begin position="823"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO31848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="971" mass="108818" checksum="48E98CB646D370B4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N578</accession>
    <name>A0A151N578_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO31984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N578"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7798" checksum="31012101674B13C9" modified="2016-06-08" version="1">MDIQVILCVYEKMFLISADTMTKGRLARRQAKEQLLHNTLSRQSKDKNRATADHIWKNLWHPEKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5K0</accession>
    <name>A0A151N5K0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">USP38</name>
        <name evidence="3" type="ORF">Y1Q_0003420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="AKHW03004037">
        <property type="protein sequence ID" value="KYO31855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5K0"/>
    <dbReference type="STRING" id="8496.A0A151N5K0"/>
    <dbReference type="eggNOG" id="KOG1864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02664">
        <property type="entry name" value="Peptidase_C19H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033840">
        <property type="entry name" value="USP38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049407">
        <property type="entry name" value="Usp38-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF660">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21246">
        <property type="entry name" value="Usp38-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="413"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="932" mass="105388" checksum="A37B0593F4C8B2D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6B3</accession>
    <name>A0A151N6B3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0020345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6B3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO32384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="74" mass="8505" checksum="61C40A676A6A9284" modified="2016-06-08" version="1">MDKKNFCSKLGRLKWKQQKKNPAVQVHHRVAMGHQHDTAMEKANAILRKKSLPRRAADKSYGHDEGNAEKAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N7Q8</accession>
    <name>A0A151N7Q8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proto-oncogene DBL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0009380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003879">
        <property type="protein sequence ID" value="KYO32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N7Q8"/>
    <dbReference type="STRING" id="8496.A0A151N7Q8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF146">
        <property type="entry name" value="PROTO-ONCOGENE DBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="7">
        <location>
            <begin position="70"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="601"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="799"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="928"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="118961" checksum="22E84C387AF4958B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAU9</accession>
    <name>A0A151NAU9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein ZIC 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZIC4</name>
        <name evidence="8" type="ORF">Y1Q_0024541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAU9"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000039">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000041">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF167">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="180" mass="19717" checksum="C40BAC2CE4685C92" modified="2016-06-08" version="1">MESSGKEQSQEMRPKTSLVMRKRKRLYRNILEKSREKPFKCEFEGCDRRFANSSDRKKHSHVHTSDKPYNCKVRGCDKSYTHPSSLRKHMKVHCKSPPPSSGYESSTPSLVSPSSDSGREPPASCSHAEPAASSQSAANLSEWYVCQSAGASAIPTPPSNSPSPGPGEASCTNCEPRPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCQ0</accession>
    <name>A0A151NCQ0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ammonium transporter Rh type A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Erythrocyte membrane glycoprotein Rh50</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rhesus blood group family type A glycoprotein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RHAG</name>
        <name evidence="18" type="ORF">Y1Q_0012983</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CO2(out) = CO2(in)</text>
            <dbReference type="Rhea" id="RHEA:74891"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NH4(+)(in) = NH4(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28747"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>methylamine(out) = methylamine(in)</text>
            <dbReference type="Rhea" id="RHEA:74391"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Heterotrimer; a RHCE monomer interacts with a RHAG homodimer. Component of the ankyrin-1 complex in the erythrocyte, composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1. Interacts with GYPB (via the N-terminal); this interaction bridges the (RHAG)2(RHCE) heterotrimer with the SLC4A1 Band 3 I dimer complexed with GYPA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003504">
        <property type="protein sequence ID" value="KYO34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267457.1">
        <property type="nucleotide sequence ID" value="XM_006267395.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCQ0"/>
    <dbReference type="STRING" id="8496.A0A151NCQ0"/>
    <dbReference type="GeneID" id="102560617"/>
    <dbReference type="KEGG" id="amj:102560617"/>
    <dbReference type="CTD" id="6005"/>
    <dbReference type="eggNOG" id="KOG3796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NCQ0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000001">
        <property type="entry name" value="Ammonium transporter Rh type C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF32">
        <property type="entry name" value="AMMONIUM TRANSPORTER RH TYPE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="17">
        <location>
            <begin position="46"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="436" mass="47419" checksum="35C0C22011A3667D" modified="2016-06-08" version="1">MPSSSFSTNMRLKFSVLAIVLEVILIALFGIFVRYKEVNIYLLGEDQTVHIELYPFFQDVHVMIFVGFGFLMTFLKKYGFTSVGINMLIAAVGLQWGTLMQGFWHMKRGEIHVTVKSMINADFSTATVLISFGALLGKTSPVQMMILAILEITLFSCNEYLVVDVLKATDTGASMTIHAFGAYFGLAVARVLYRPGLKKGHENEGSSYHSDMFAMIGTLFLWLFWPSFNSAIAAPGDPQYRAIVNTYFSLAACTVTAFAFSSLTEHRGKFDMVHIQNATLAGGVAVGSCADLGIQSFGAMLIGFVAAIISVIGFKFLTPFFASYLKIQDTCGVHNLHGLPGLLGGIASIIAAAVKVEHAPFHPVSPGMQAAALGCTLGIALIGGAFAGLILNLPFLGQAPDQNCYNDSVYWEVPEETKQLVEMPSEQDTQRFNINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NCZ8</accession>
    <name>A0A151NCZ8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor AP-2-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">AP-2 transcription factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Activating enhancer-binding protein 2-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Activator protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0015477</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003364">
        <property type="protein sequence ID" value="KYO34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NCZ8"/>
    <dbReference type="STRING" id="8496.A0A151NCZ8"/>
    <dbReference type="eggNOG" id="KOG3811">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252992at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008121">
        <property type="entry name" value="TF_AP2_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01749">
        <property type="entry name" value="AP2ATNSCPFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="16">
        <location>
            <begin position="205"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="431" mass="47082" checksum="C91405AE6026B13D" modified="2016-06-08" version="1">MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQETGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHGLSSGLGDIPIHSIPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNANAVSSIPINKDALFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDSSTKSGDKEEKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDZ1</accession>
    <name>A0A151NDZ1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0000921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDZ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="266" mass="29986" checksum="06A9364EC18BABD9" modified="2016-06-08" version="1">MSGQGQQRSIPQGKMDRLRQMLKNRTPRVSPGEEDSSRRPGLKEEGHPIVIPYRPGKEVEEEQEGEDLMLLEEEALIDIIQHLQGQGKDKEHGERFLLAIPTLCRATKQRGKDNLEPETCKMVLLQKIMPYRTVSESCIWRAAEVGSGCERLAPGGLMETATQDEEPNWTLCNSIAAICSLSELKPALEPAMESCLLQTTLKICLTSPRHNSLYVRTKQQKHMEDLEALLRSLLATAPSLDRLQFLWEVSTVWRSWALGRDCLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NE11</accession>
    <name>A0A151NE11_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Double zinc ribbon and ankyrin repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DZANK1</name>
        <name evidence="12" type="ORF">Y1Q_0010517</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003332">
        <property type="protein sequence ID" value="KYO34775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NE11"/>
    <dbReference type="STRING" id="8496.A0A151NE11"/>
    <dbReference type="eggNOG" id="ENOG502QTJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042462">
        <property type="term" value="P:eye photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052481">
        <property type="entry name" value="DZAN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026876">
        <property type="entry name" value="Fn3_assoc_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16058">
        <property type="entry name" value="DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16058:SF4">
        <property type="entry name" value="DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13287">
        <property type="entry name" value="Fn3_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZANK-type" evidence="11">
        <location>
            <begin position="407"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="718"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO34775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="830" mass="91655" checksum="C6E6EFDE491444B2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NF20</accession>
    <name>A0A151NF20_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein 407</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZNF407</name>
        <name evidence="8" type="ORF">Y1Q_0007970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NF20"/>
    <dbReference type="STRING" id="8496.A0A151NF20"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001710">
        <property type="entry name" value="Zinc finger protein 407 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF60">
        <property type="entry name" value="ZINC FINGER PROTEIN 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="614" mass="68377" checksum="6DCED60E514A8F03" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NF38</accession>
    <name>A0A151NF38_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 66 member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PQ-loop repeat-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PQLC1-1</name>
        <name evidence="9" type="ORF">Y1Q_0007997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NF38"/>
    <dbReference type="STRING" id="8496.A0A151NF38"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000005">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000008">
        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 66 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO35422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="300" mass="34434" checksum="684CB8047627E0BF" modified="2016-06-08" version="1">MGALHRLQSRQCSSKNRPDCCCGPRLQSVMETNGLEWLVVPMQQLVSWGAAGAMVFGGVVPYIPQYRDIKRTQNAEGFSTYVCLVLLVANILRILFWFGRRFESPLLWQSIIMIITMLLMLKLCTEVRVSNELNLKRRSFAAADSKDEDIKAPPKRSYLDFDLKYFWHWSKFTDYMQCVLTFTGVTGYITYLSLDSFLFVETLGFLAVFTEAMLGIPQLYRNHQNRSTEGMSVKMVVMWTSGDTFKTVYFILNQAPFQFSICGLLQVFVDIAILLQVYFYSYYPQKPASHTAHPVSTKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG53</accession>
    <name>A0A151NG53_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATP-binding cassette sub-family G member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ABCG1</name>
        <name evidence="18" type="ORF">Y1Q_0010168</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003120">
        <property type="protein sequence ID" value="KYO35730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG53"/>
    <dbReference type="STRING" id="8496.A0A151NG53"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034041">
        <property type="term" value="F:ABC-type sterol transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000267">
        <property type="entry name" value="ATP-binding cassette, sub-family G (WHITE), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF75">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0768">Sushi</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586030" evidence="15">
        <location>
            <begin position="17"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="17">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="277"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO35730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="861" mass="95567" checksum="2DCF79A0E6D06EB8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHL6</accession>
    <name>A0A151NHL6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Microsomal glutathione S-transferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MGST2</name>
        <name evidence="9" type="ORF">Y1Q_0020647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003015">
        <property type="protein sequence ID" value="KYO36149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261779.1">
        <property type="nucleotide sequence ID" value="XM_006261717.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHL6"/>
    <dbReference type="STRING" id="8496.A0A151NHL6"/>
    <dbReference type="GeneID" id="102568988"/>
    <dbReference type="KEGG" id="amj:102568988"/>
    <dbReference type="CTD" id="4258"/>
    <dbReference type="eggNOG" id="ENOG502S082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019370">
        <property type="term" value="P:leukotriene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000003">
        <property type="entry name" value="Leukotriene C4 synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001446">
        <property type="entry name" value="5_LipOase_AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF13">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00488">
        <property type="entry name" value="5LPOXGNASEAP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0434">Leukotriene biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586074" evidence="8">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO36149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="147" mass="16649" checksum="0FBF9795101EC50B" modified="2016-06-08" version="1">MAGDLMLLAAISLLSACQQSYFAWLVGKSRKKHKIMPPAVTGPPEFERTFRAQQNCVEYYPVFLVDLWIAGWFFNQEVAALLGLAYMFARHKYFHGYAESVKGRLTGFYWSLVVLIVLLALGTAGIANSFLDEYLNFSVAKKLRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NI29</accession>
    <name>A0A151NI29_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloproteinase inhibitor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Tissue inhibitor of metalloproteinases 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TIMP3</name>
        <name evidence="18" type="ORF">Y1Q_0024158</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006271730.1">
        <property type="nucleotide sequence ID" value="XM_006271668.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NI29"/>
    <dbReference type="STRING" id="8496.A0A151NI29"/>
    <dbReference type="GeneID" id="102557878"/>
    <dbReference type="KEGG" id="amj:102557878"/>
    <dbReference type="CTD" id="7078"/>
    <dbReference type="eggNOG" id="KOG4745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03585">
        <property type="entry name" value="NTR_TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.370.10:FF:000001">
        <property type="entry name" value="Metalloproteinase inhibitor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.120:FF:000005">
        <property type="entry name" value="Metalloproteinase inhibitor 3 precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.370.10">
        <property type="entry name" value="Tissue inhibitor of metalloproteinase-1. Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027465">
        <property type="entry name" value="TIMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030490">
        <property type="entry name" value="TIMP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF22">
        <property type="entry name" value="METALLOPROTEINASE INHIBITOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00288">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="6 18" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="7 18" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586087" description="Metalloproteinase inhibitor 3" evidence="16">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="17">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="151"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO36410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="212" mass="24299" checksum="F4FAFC1E78C090A0" modified="2016-06-08" version="1">MPAGWLSLLALLCSWSLSALVAEACTCVPIHPQDAFCNSDIVIRAKVVGKKLMKDGPFGTMRYTVKQMKMYRGFQIMPHVQYIYTEASESLCGVKLEVNKYQYLITGRVYEGKVYTGLCNWYEKWDRLTQAQRKGLNHRYHLGCGCKIRPCYYLPCFVTSKSECIWTDMLSSFGHSGYQSKNYACIQRVEGYCSWYRGWAPPDKTIINATDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NI74</accession>
    <name>A0A151NI74_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="4">PARP</shortName>
            <ecNumber evidence="4">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0024226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NI74"/>
    <dbReference type="STRING" id="8496.A0A151NI74"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061014">
        <property type="term" value="P:positive regulation of mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF8">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE ANTIVIRAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WWE" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="7">
        <location>
            <begin position="104"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO36498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="368" mass="42074" checksum="2C0B6FE822762E9E" modified="2016-06-08" version="1">MEYAWYWQDEHGEWIEYGQPKLNHSAATITSEELEEAFLNNQKKMVLFKAGSQYYELNFQDMFQRNLHYQTQRKVCRWPKFVSSGHSNKGWRRRSRTAAPGCPFPPDWDLSALPDVGYKLVDVSSIASEYMRIKDLFEKTMQCYYIHKLQRIQNPSLWQVFQWQKEQMKKINRQEDVDERLLFHGTNTSHLHAICEQNFDWRICGAHGTAYGKGSYFAKDARYSHGYCDPNSSHKTMFVAQSGILSKALPQGAAGQDTTSTSPSLEEGGGAAPSNLQAKDTRHSWLLSLMGWPALSYQPLHPWTCGPTSGHGGEPTSPSEDVASVLPSATGALYVCCLCQQWIQNWMLLLQWLVTVAEEQEAQEQAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Protein FAM60A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM60A</name>
        <name evidence="2" type="ORF">Y1Q_0024274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIE1"/>
    <dbReference type="STRING" id="8496.A0A151NIE1"/>
    <dbReference type="eggNOG" id="ENOG502QSAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026065">
        <property type="entry name" value="FAM60A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13422">
        <property type="entry name" value="SIN3-HDAC COMPLEX-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13422:SF12">
        <property type="entry name" value="SIN3-HDAC COMPLEX-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15396">
        <property type="entry name" value="FAM60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="239" mass="26887" checksum="E562CCCF33770236" modified="2016-06-08" version="1">MASVKTLPPTDNSKERRMFGFHKPKMYRSIEGCCICRAKSSSSRFTDSKRYEKDFQNCFGLHEARSGDICNACVLLVKRWKKLPAGSKKNWNHVVDARAGPSLKTTLKPKKMKTLSGSRMKSNQISKLQKEFKRHNSDAHSTTSSASPAQSPCYSNQSDDGSDTEMSPGSSRTPIFSFLDLTYWKRQKVCCGIIYKGRFGEVLIDTHLFKPCCSNKKSATEKPEPQGPQSPAISNQEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NIH3</accession>
    <name>A0A151NIH3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NIH3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO36550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="119" mass="13783" checksum="75D65E52FD94AFC6" modified="2016-06-08" version="1">MPLEYVALDVSQVTRSRGHQGTPDVLNQPVEPGRKKARMSQTFTKLRYAFPSQQQRTQLQNQEGHVFLMGNMFTQPHLDWHSQYKSTSSTAFCLQVLFCILQKHFFFLVNTLAVRHVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNS3</accession>
    <name>A0A151NNS3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNS3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="68" mass="7452" checksum="FC14C9AB4B5768BE" modified="2016-06-08" version="1">MCQETVPARSISTDANKNFLVDDLPKLALAASSGKLKNSNTRSFSVCRADDKATWTRSTEGLRCSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNZ9</accession>
    <name>A0A151NNZ9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing-splicing factor 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Splicing factor Prp8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PRPF8</name>
        <name evidence="12" type="ORF">Y1Q_0016900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002446">
        <property type="protein sequence ID" value="KYO38551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NNZ9"/>
    <dbReference type="eggNOG" id="KOG1795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000003">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="2028"/>
            <end position="2159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO38551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2260" mass="264950" checksum="65428CC25E4676A1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPB8</accession>
    <name>A0A151NPB8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0023400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="89" mass="9758" checksum="D76848386096A706" modified="2016-06-08" version="1">MHCGKLSAQKPTTTSRGPAILSAVLASTGRCCRPRGWPFQWLPAHPEQVGERIVLQVXXXXXXXYQYASVPNSAPSVKKYPPALSGYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQK0</accession>
    <name>A0A151NQK0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GLB1L2</name>
        <name evidence="10" type="ORF">Y1Q_0022577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03002395">
        <property type="protein sequence ID" value="KYO38980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006276324.2">
        <property type="nucleotide sequence ID" value="XM_006276262.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQK0"/>
    <dbReference type="STRING" id="8496.A0A151NQK0"/>
    <dbReference type="GeneID" id="102568427"/>
    <dbReference type="KEGG" id="amj:102568427"/>
    <dbReference type="CTD" id="89944"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000049">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000036">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="51"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="421"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="9">
        <location>
            <begin position="547"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO38980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="635" mass="72135" checksum="FCCCD4060286106B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NRM4</accession>
    <name>A0A151NRM4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein phosphatase 1F</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Ca(2+)/calmodulin-dependent protein kinase phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PPM1F</name>
        <name evidence="20" type="ORF">Y1Q_0018599</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Associates with FEM1B.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NRM4"/>
    <dbReference type="STRING" id="8496.A0A151NRM4"/>
    <dbReference type="PhylomeDB" id="A0A151NRM4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000032">
        <property type="entry name" value="Protein phosphatase, Mg2+/Mn2+-dependent, 1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF233">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 18" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="19">
        <location>
            <begin position="142"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO39496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="502" mass="56331" checksum="671B8EA5999C33B8" modified="2016-06-08" version="1">MAMALQAETEEARGVLGSFLRDFPAPLGPEEPPPWSPRGSGALSRAEAWGELAELARALLGARNAPPLLTAALIHAATDEVLQTDLSTFEKSSVEEEQGDQQRLTLLDGVSLQRYFFNKLRDICCEWQKQLPLLKPLKRFLLVSIHAIRNTRRKMEDRHVSLLEFNQLFGMTDDIDRAYFAVFDGHGGVDAANYAATHLHVNIALHDEFLKNPSEALKCSFQQTDEMFLLKAKRERLRNGTTGVCALIVGNRLHIAWLGDSQVMLVRQGKAVTLMEPHKPEREDERTRIEALGGYVTYLDCWRVNGTLAVSRAIGDIYQKPYVSGSADVDSFELTGSEDYLVLACDGFFDTVKPCDVMDLVLDHLMKNKGDGFKTAQRLVAAAKENGSSDNITVLVVFLRDPQDILADFLRDPKSLVIGEGGSEWEYKRKKPLYKRTRRIATPRYRQKGLGSKALSACKGEINSVTAKASEEWPIQPKECQITFLYHMERRTDCCKGCYPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NS68</accession>
    <name>A0A151NS68_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PPTC7</name>
        <name evidence="12" type="ORF">Y1Q_0018747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="AKHW03002185">
        <property type="protein sequence ID" value="KYO39711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006267701.1">
        <property type="nucleotide sequence ID" value="XM_006267639.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NS68"/>
    <dbReference type="STRING" id="8496.A0A151NS68"/>
    <dbReference type="GeneID" id="102564283"/>
    <dbReference type="KEGG" id="amj:102564283"/>
    <dbReference type="CTD" id="160760"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NS68"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000009">
        <property type="entry name" value="Blast:Protein phosphatase PTC7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO39711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="297" mass="32299" checksum="39F7C6ACA471DBE5" modified="2016-06-08" version="1">MFSVLSYGRLVARAVLGGLSQTDSRDYSLVTASCGFGKDFRKGILKKGVCYGDDACFVARHRCADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPVGILTTSYCELLQNKVPLLGSSTACIVVLDRTSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQELKKLKNSNYESIQQTARSIAEQAHELAYDPTYMSPFAQFACDNGLNVRGGKPDDITVLLSIVAEYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NT85</accession>
    <name>A0A151NT85_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0006762</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NT85"/>
    <dbReference type="STRING" id="8496.A0A151NT85"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151NT85"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099151">
        <property type="term" value="P:regulation of postsynaptic density assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000012">
        <property type="entry name" value="Leucine rich repeat containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000076">
        <property type="entry name" value="Leucine-rich repeat and Ig domain-containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF102">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586344" description="Ig-like domain-containing protein" evidence="16">
        <location>
            <begin position="20"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="333"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO39900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="624" mass="70029" checksum="F1506B81943C0F22" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUR5</accession>
    <name>A0A151NUR5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">IWS1-like protein isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IWS1</name>
        <name evidence="12" type="ORF">Y1Q_0013219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001930">
        <property type="protein sequence ID" value="KYO40400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUR5"/>
    <dbReference type="STRING" id="8496.A0A151NUR5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000001">
        <property type="entry name" value="IWS1, SUPT6H interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="533"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="615"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO40400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="798" mass="90351" checksum="7E4647F42E209149" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVK6</accession>
    <name>A0A151NVK6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0009439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03001862">
        <property type="protein sequence ID" value="KYO40763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVK6"/>
    <dbReference type="STRING" id="8496.A0A151NVK6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF454">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase p58-like C-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO40763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="228" mass="25770" checksum="AEDA8ABF8B74BD32" modified="2016-06-08" version="1">MVFLPLKVDKLRAAWEGPWLILDRLDDVTYVESESGSHKKPKVVHVNMLKSYIDRGEMVFWVSPADSSPEDPEEPVMYGDWDGETGIEELRLPDHLLSQDKDKLLTILKDYEMMFSNKPVNAKVMEGIKQELAEMRELGVIWPSTSPWASPVVLVQKQDGTIRFCVDYRKLNAITTPDAYPMPRTDSLLDRLGPANIISTLDLSKGFWQMALDPDAMAKSAFTTPVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NVR9</accession>
    <name>A0A151NVR9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001768">
        <property type="protein sequence ID" value="KYO41002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NVR9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="121" mass="12892" checksum="981D2C8CC7233DD4" modified="2016-06-08" version="1">MLSCPLDSENLRQRPTLARSTQNKEAAMSGKQPGQAEITGKNSAAWCNIQNLLSSVGLLLNSPVSPYITEDDSQGCTPAVPASHREHGLGPGPLSSPPWTWTLSLEDWMLGLHGAGQKIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NW92</accession>
    <name>A0A151NW92_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PHD finger protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PHF20</name>
        <name evidence="10" type="ORF">Y1Q_0013738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001786">
        <property type="protein sequence ID" value="KYO40993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NW92"/>
    <dbReference type="STRING" id="8496.A0A151NW92"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
        <property type="entry name" value="MBT_PHF20L1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20453">
        <property type="entry name" value="Tudor_PHF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000043">
        <property type="entry name" value="PHD finger protein 20 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000196">
        <property type="entry name" value="PHD finger protein 20 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043449">
        <property type="entry name" value="PHF20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022255">
        <property type="entry name" value="PHF20_AT-hook"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856:SF27">
        <property type="entry name" value="PHD FINGER PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856">
        <property type="entry name" value="PHD FINGER PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12618">
        <property type="entry name" value="PHF20_AT-hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="441"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO40993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1058" mass="122214" checksum="4A10986127293074" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWD7</accession>
    <name>A0A151NWD7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CREB3L3-1</name>
        <name evidence="17" type="ORF">Y1Q_0011899</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001665">
        <property type="protein sequence ID" value="KYO41187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWD7"/>
    <dbReference type="STRING" id="8496.A0A151NWD7"/>
    <dbReference type="eggNOG" id="KOG0709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14689">
        <property type="entry name" value="bZIP_CREB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000042">
        <property type="entry name" value="Cyclic AMP-responsive element-binding protein 3-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051381">
        <property type="entry name" value="CREB_ATF_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996">
        <property type="entry name" value="AGAP001464-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45996:SF1">
        <property type="entry name" value="CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BZIP" evidence="16">
        <location>
            <begin position="267"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="69"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO41187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="499" mass="54838" checksum="6E45E25432432E42" modified="2016-06-08" version="1">MTFHQFLPMEELTPAGSILRRPCAWSWAGDKDMASSCQMSSINSLELLDLLFDRQDGILRNVEFGGPVAAWPGPEDSQLPGSQENEDFLSSLLGSGDSVSDSSAWSPAASDSGISEDPTSDQLDSPPGYVPGSSPGGYSDGGHGEPMYSYQDSCQALPVLKVPVADLRDTEVSIDLDMWNSGFFPEDSQDLPAPSQLPSSCTLTVKDLLLSGSSETQQQQQMNPVLLRQGPGHCQELVLTEDEKKLLAKEGMTLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNSSLLEQLRKLQALVMQSSNKAAQTGTCIVVLLLSFALIVFPSISPFAHNKAETSSDFGPVRVFSRSLHNDDSSRVVYALGKDGEERPKEPEKPLWTEYAKEKEPKRQGALRKFLSSHLLPEPAVETTLSNRTEALPQDGHSDLEGLSHDDRVVGHGLASLAWTDPGQPSQVVLEPADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWX0</accession>
    <name>A0A151NWX0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoplasmic protein NCK2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NCK2</name>
        <name evidence="8" type="ORF">Y1Q_0006205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWX0"/>
    <dbReference type="STRING" id="8496.A0A151NWX0"/>
    <dbReference type="eggNOG" id="KOG4226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903898">
        <property type="term" value="P:negative regulation of PERK-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902237">
        <property type="term" value="P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036493">
        <property type="term" value="P:positive regulation of translation in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11902">
        <property type="entry name" value="SH3_Nck2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11903">
        <property type="entry name" value="SH3_Nck2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000110">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000126">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035560">
        <property type="entry name" value="Nck2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035561">
        <property type="entry name" value="Nck2_SH3_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF12">
        <property type="entry name" value="CYTOPLASMIC PROTEIN NCK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="239"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO41376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="301" mass="33652" checksum="E9B2001FD6DE41C2" modified="2016-06-08" version="1">MNVSGCWMIPKHGGGLKKGSLVKNLKDTLGLGKTKRKTSARDASPTPSTDAEYPSNGSSADRIYDLNIPAYVKFAYVAEREDELSLVKGSRVIVMEKCSDGWWRGSYNGQIGWFPSNYVVEEVEEATADSPSFLSLRKGASMSNGQGTKVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNSRGQIGLVPKNYVVILNDGPTINPSHPPQISYTGPSSTGRFAGREWYYGNVTRHQAECALNERGVEGDFLVRDSESSPSDFSVSLKASGKNKHFKKESFRVYRRWRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZI6</accession>
    <name>A0A151NZI6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450 26A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CYP26A1</name>
        <name evidence="19" type="ORF">Y1Q_0022166</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-(4S)-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51492"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35291"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:134185"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51493"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZI6"/>
    <dbReference type="STRING" id="8496.A0A151NZI6"/>
    <dbReference type="GeneID" id="102575941"/>
    <dbReference type="KEGG" id="amj:102575941"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NZI6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008401">
        <property type="term" value="F:retinoic acid 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034653">
        <property type="term" value="P:retinoic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20638">
        <property type="entry name" value="CYP26A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000041">
        <property type="entry name" value="Cytochrome P450 26A1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF101">
        <property type="entry name" value="CYTOCHROME P450 26A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586509" description="Cytochrome P450 26A1" evidence="18">
        <location>
            <begin position="29"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO42301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="493" mass="55081" checksum="97D2BD6373AC5A6F" modified="2016-06-08" version="1">MGFALLASALCTLLLPLLLFLAAVKLWGLYCESGRDPGCPLPLPPGTMGLPFFGETLQMVLQRRKFLQVKRRKYGCIYKTHLFGRPTVRVLGADNVRRILLGEHRLVAVQWPASVRTILGSGCLSNLHDARHKQRKKVIMRAFSRDALRHYAPVMQEEVSGCLARWLGRGGACLLVYPEVKRLMFRIAMRLLLGFEPHQADSGSERQLVEAFEEMSRNLFSLPIDVPFSGLYRGLRARNIIHARIEANIRNRMARAEPGGGPKDALQLLLEQAQRHGQPLNMQELKESATELLFGGHETTASAATSLITFLGLHPEVLQKVRKELQGNGLLCSPNQDSKTLDMEVLEQLKYTGCVIKETLRLSPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAELFTNKDKFNPDRFMSPSPEDSSRFSFIPFGGGVRSCVGKEFAKILLKIFTVELARNCDWQLLNGPPTMKTGPIVYPVDNLPAKFVGFSGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZJ0</accession>
    <name>A0A151NZJ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Myoferlin isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MYOF</name>
        <name evidence="17" type="ORF">Y1Q_0022167</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019339785.1">
        <property type="nucleotide sequence ID" value="XM_019484240.2"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NZJ0"/>
    <dbReference type="GeneID" id="106736744"/>
    <dbReference type="CTD" id="26509"/>
    <dbReference type="eggNOG" id="KOG1326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08373">
        <property type="entry name" value="C2A_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000021">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000026">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000037">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
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    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037726">
        <property type="entry name" value="C2A_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012560">
        <property type="entry name" value="Ferlin_A-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF55">
        <property type="entry name" value="MYOFERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08165">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01200">
        <property type="entry name" value="FerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="2044"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="182"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="340"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1121"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1284"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1553"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1789"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="932"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1019"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1995"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1995"/>
            <end position="2008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO42302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="2078" mass="235604" checksum="5B92C7FF1DA38D10" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NZV5</accession>
    <name>A0A151NZV5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroidogenic acute regulatory protein, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">START domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0022268</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Steroid metabolism; cholesterol metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May interact with TSPO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NZV5"/>
    <dbReference type="eggNOG" id="KOG3845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NZV5"/>
    <dbReference type="UniPathway" id="UPA00296"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050810">
        <property type="term" value="P:regulation of steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029866">
        <property type="entry name" value="StAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46489">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46489:SF1">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="12">
        <location>
            <begin position="101"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="290" mass="32767" checksum="67A30BF93C42D8B8" modified="2016-06-08" version="1">MLPATFKLCCGISHDHLRSITGLKRTAMAAIGHDLQGMMLKGSHCLPSKLPGYVQRLMWKDTAGTQEDGTGISSVWFSSTELSYVNQGEVTLHRAMEILQQQNGWQMETKQGNGDAVLSTVIPQLGKVFRIEVVLAVPMDQLYHELFESLERMPEWNPTLSQVKILQRIGKDTLLTHEIASQSPGNLVGQRDFVNIRRCWKKETAVYLVGTAAYSELIPLQEEQVRAEATLSCIVLQPLEENPMQTRFTWLLSMDLKGWIPKSVINYVLPQSQVDFIKHLRQHLSISAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0N0</accession>
    <name>A0A151P0N0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">COPE</name>
        <name evidence="15" type="ORF">Y1Q_0000346</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001362">
        <property type="protein sequence ID" value="KYO42687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006271076.1">
        <property type="nucleotide sequence ID" value="XM_006271014.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0N0"/>
    <dbReference type="STRING" id="8496.A0A151P0N0"/>
    <dbReference type="GeneID" id="102575919"/>
    <dbReference type="KEGG" id="amj:102575919"/>
    <dbReference type="CTD" id="11316"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000148">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO42687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="309" mass="34427" checksum="EDB312AB43E43411" modified="2016-06-08" version="1">MAAGAAAAAGGGSAGDADELFDVKNSFYIGAFQAAINEAQRVKLSSPEREVERDVFLYRAYIAQRKYGVVLDEIRANACPELQAVKMFAEYLSSESQRDAIVADLDKKMAKSVDVTNTTFLLMAASIYFHDKNPDAALRTLHQGESLECMAMMIQILLKLDRLDLARKELKKMQEQDEDATLTQLATAWVNLAIGGEKLQDAYYIFQEMADKSSPTLLLLNGQAACYMAQGKWEDAEGVLQEALDKDSSHPETLINFVVLSQHLGKPPEVTNRYLSQLKDAHKNHPFIKEYQAKENDFDRLVMQYAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P0N1</accession>
    <name>A0A151P0N1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001467">
        <property type="protein sequence ID" value="KYO42460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P0N1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO42460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="11079" checksum="BB51E62E781F6024" modified="2016-06-08" version="1">MHFGLCFSETSDLQSRVSHLEADRSSQLPAWLSADQMETAILGRVDQLLEEKLKFSLPRHREVRETHQRCNCPAGAAPAGAMDYCDRRLKTRLRYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P258</accession>
    <name>A0A151P258_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0017491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="1"/>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P258"/>
    <dbReference type="STRING" id="8496.A0A151P258"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd12093">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044912">
        <property type="entry name" value="Egfr_JX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Epidermal growth factor receptor-like transmembrane-juxtamembrane segment" evidence="9">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO43161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="138" mass="14528" checksum="6C130D043937F11E" modified="2016-06-08" version="1">MALGATIAPKVQSGVVARVASGPQSAVSDDAGVVGSLLCLVVIALGIGLYLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKVKVLGSGAFGTVYKGPLVSLAITVVSASPRSCSEVFTTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2E1</accession>
    <name>A0A151P2E1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat and BTB domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KBTBD2</name>
        <name evidence="4" type="ORF">Y1Q_0017558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2E1"/>
    <dbReference type="STRING" id="8496.A0A151P2E1"/>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18479">
        <property type="entry name" value="BACK_KBTBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047074">
        <property type="entry name" value="KBTBD2_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF5">
        <property type="entry name" value="KELCH-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO43248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="662" mass="75610" checksum="24F66AC7DBD49FC4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P339</accession>
    <name>A0A151P339_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CUB domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CDCP1</name>
        <name evidence="8" type="ORF">Y1Q_0017609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P339"/>
    <dbReference type="STRING" id="8496.A0A151P339"/>
    <dbReference type="eggNOG" id="ENOG502QVKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038811">
        <property type="entry name" value="CDCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056266">
        <property type="entry name" value="CDCP1_CUB_3rd_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056268">
        <property type="entry name" value="CUB_CDCP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056269">
        <property type="entry name" value="CUB_CDCP1_2nd_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056965">
        <property type="entry name" value="CUB_CDCP1_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14477">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14477:SF1">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23665">
        <property type="entry name" value="CDCP1_CUB_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23667">
        <property type="entry name" value="CUB_CDCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23668">
        <property type="entry name" value="CUB_CDCP1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25142">
        <property type="entry name" value="CUB_CDCP1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586618" evidence="3">
        <location>
            <begin position="24"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="CDCP1 first CUB" evidence="5">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="CDCP1 second and fifth CUB" evidence="6">
        <location>
            <begin position="101"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CDCP1 third and sixth CUB" evidence="4">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CDCP1 fourth CUB" evidence="7">
        <location>
            <begin position="283"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="CDCP1 second and fifth CUB" evidence="6">
        <location>
            <begin position="381"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="CDCP1 third and sixth CUB" evidence="4">
        <location>
            <begin position="482"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO43329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="793" mass="88982" checksum="D39207B51568BD12" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4B5</accession>
    <name>A0A151P4B5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Scavenger receptor cysteine-rich domain-containing protein DMBT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Deleted in malignant brain tumors 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Hensin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0012828</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DMBT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001049">
        <property type="protein sequence ID" value="KYO43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4B5"/>
    <dbReference type="KEGG" id="amj:102566472"/>
    <dbReference type="OrthoDB" id="10063988at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4100:FF:000005">
        <property type="entry name" value="Deleted in malignant brain tumors 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000003">
        <property type="entry name" value="Deleted in malignant brain tumors 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000004">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017977">
        <property type="entry name" value="ZP_dom_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF38">
        <property type="entry name" value="CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00682">
        <property type="entry name" value="ZP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586658" description="Scavenger receptor cysteine-rich domain-containing protein DMBT1" evidence="20">
        <location>
            <begin position="21"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="22">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="21">
        <location>
            <begin position="187"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="23">
        <location>
            <begin position="306"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="573" mass="63730" checksum="546211711778DF11" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5D0</accession>
    <name>A0A151P5D0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0001746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000840">
        <property type="protein sequence ID" value="KYO44213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5D0"/>
    <dbReference type="STRING" id="8496.A0A151P5D0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO44213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="344" mass="37497" checksum="4E20C370F894829A" modified="2016-06-08" version="1">MRPYLTPPGVISQAVRGILHVVREAGGHNCSCSVSMSYLEAYQEKCWISWSRQGGTWTHWVARPTAVVASEQRFYFDTLTTLNFATCSKQVVNKPFAPGALPEPAAEETAEGEQQQTNSLPARKLPWLLRSPLGAMAGGGGGRGQCVGVRQGEMGAAQLAPSLPPSSALLPLAQLEPSLRLEEVEWQQGTGHRGLPLLGTPKAARKALLCCLKETQAELEKMRQQQKELEAKEQLRAASTPEPPQAVILPMQQAPFGLSFPLLSAVLIPQKWASPTEDEGILVLKRRLGPGGTESVVPSWELTRCQEVMVRGHQKLLELLNHGSTRELLSLKRIGPRTAELLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P6H2</accession>
    <name>A0A151P6H2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase TRIM39-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0023104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000760">
        <property type="protein sequence ID" value="KYO44499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P6H2"/>
    <dbReference type="eggNOG" id="KOG2177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="273"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="133"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO44499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47676" checksum="2B31F63C210640BF" modified="2016-06-08" version="1">MAAEGPARSLQKQVTCSVCPDCAADPGAPGCGNSRCQACTGEPEPEPHVLCPQCRAAAPQRPLRPKRQLGDVLELVKRLRLPAASGPGGQRVCERHQEALTLFCREDEAPMCAGCGESRAHAAHTVVPMEEAAQDYREKIQSCLEHLKDQREELQSLKCTWEQESERLLRQTELERQLVVSECEELRQLLAEQKHLLLTRLEELNTEIVRRREENATRLCKETARLSALITELEEKCHQLGPERLQGVRSAVTRGEEVTPLHPAPKFPEQKRIQNFCGEKKLQEAQTGFLVNVTLDPDTANPNLVLSEDRKCVRHGDTRQDLPDNPERFDPCVFVLGSQRFTGGRHYWEVEVGDKTDWALGVCRESVRKKGQVTFTPGNGYWTVWLWDGAYKALTSPTAPFPVRVQPRQVGVFLDYEAALGKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P718</accession>
    <name>A0A151P718_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000643">
        <property type="protein sequence ID" value="KYO44858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P718"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO44858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="7785" checksum="EB003CAA447B79D3" modified="2016-06-08" version="1">MWQGRDGGGSRCKVLYRHTMQGNGLRLEMRNSPHDQGLGPGTWVKEVGGPASPPTPRSCSQPGSPPSRDWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8C6</accession>
    <name>A0A151P8C6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cathepsin W-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0019895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000596">
        <property type="protein sequence ID" value="KYO45347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8C6"/>
    <dbReference type="STRING" id="8496.A0A151P8C6"/>
    <dbReference type="eggNOG" id="KOG1542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="247"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO45347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="397" mass="43786" checksum="A25337B46C6659A8" modified="2016-06-08" version="1">MTRFSDLTEEEFRAQLLSPMPGHTLRPPAQSPSKPAPPSCDWRKAGAVTPAKNQGLCGSCWAFAAVANIESLWFIRHQELYNLSVQQVLDCSRLQVACGGAFPWDAFTVAWMYGLTQEEQYPYMGCQNLCESRHQAVACIETFQFLSSDEKKLAAHIAARGPVTVCINADLLQFYVEGIITKNMACHCNPEETNHAVLLVGYGLEKKTPYWIVKNSWGPEWGEEGFFRIYRGGNACGIASLPVTAMVPEGLTPEEQYPYMACQNMCQESHRAVAHVQTFQILSSDEKKLAAHIAVQGPVTVGINAKLLQFYEEGIITKNMACSCNPDEMNHAVLLVGYGLEKKTPYWIVKNSWGPEWGEEGSFRIYRGGNACGIASLPVTATVAEDDSGDILVSCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8R2</accession>
    <name>A0A151P8R2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Solute carrier family 25 member 47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial NAD(+) transporter SLC25A47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC25A47</name>
        <name evidence="19" type="ORF">Y1Q_0015092</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>NAD(+)(in) = NAD(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:65408"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA(in) = acetyl-CoA(out)</text>
            <dbReference type="Rhea" id="RHEA:75039"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019337133.1">
        <property type="nucleotide sequence ID" value="XM_019481588.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8R2"/>
    <dbReference type="STRING" id="8496.A0A151P8R2"/>
    <dbReference type="GeneID" id="102558607"/>
    <dbReference type="KEGG" id="amj:102558607"/>
    <dbReference type="CTD" id="283600"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000069">
        <property type="entry name" value="Solute carrier family 25 member 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000072">
        <property type="entry name" value="solute carrier family 25 member 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="93"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="199"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO45422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="292" mass="31911" checksum="0545703D78C100C8" modified="2016-06-08" version="1">MDFIAGAIGGGLSTAVGYPLDTVKVRIQTERSYNGIWHCIQEVYKTEKILGFYKGMSMSVLTVSLISSVSFGTYRNCLYNICRLRYGTSDAKPSKVDISLAGCATGVVRVLLISPAEITKVRMQTQKPHHSVATSDPSSKPKYRGSMHCLKMIAKEEGFGGLYRGCSALLCRDCYSSALYFLTYSVLCDWLTPAGKSKPDIFAVLVSGGCAGMLGWGVATPMDVIKSRLQADELGQHKYRGLMHCARESVKAEGLTVLFKGLGLNCIRAFPVNMVVFVTYEAVLRLAEHLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8R5</accession>
    <name>A0A151P8R5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor 1-delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Y1Q_0014735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000629">
        <property type="protein sequence ID" value="KYO45299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8R5"/>
    <dbReference type="STRING" id="8496.A0A151P8R5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF26">
        <property type="entry name" value="ELONGATION FACTOR 1-DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="274"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO45299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="360" mass="39253" checksum="1113B5540842F8C0" modified="2016-06-08" version="1">MRTSGRSILAAAAGGGGACDVPGASPPPPPAVGRSRGPECPARGNRLPLPGWRPRGRSAEMAANFLMHEKIWFDKYKYDDAERRYYEQINGPVASSSCQQENGASTILRDIARARENIQKSLAGSASTTSAAGPSGDQSELISRISSLELENRNLRSVVADLQHAISKLESRLSTLERSSTSHQSSAPLPTQHVTPMKKVEPLSVSSKKVELPSAPPARKTAEPAAADEDEDDDDIDLFGSDDEEEDQEAAMVREERLRQYAEKKSKKPGLIAKSSILLDVKPWDDETDMAKMEECVRSVQMDGLVWGASKLVPVGYGIKKLQIQCVVEDDKVGTDILEEEITKFEDYVQSVDIAAFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P919</accession>
    <name>A0A151P919_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Echinoderm microtubule-associated protein-like 6 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EML6</name>
        <name evidence="13" type="ORF">Y1Q_0015184</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat EMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000563">
        <property type="protein sequence ID" value="KYO45538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P919"/>
    <dbReference type="GeneID" id="102559100"/>
    <dbReference type="CTD" id="161436"/>
    <dbReference type="eggNOG" id="KOG2106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000040">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000042">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000044">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000024">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000035">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000037">
        <property type="entry name" value="Putative echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF16">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="53"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="328"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="719"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="899"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like first beta-propeller" evidence="11">
        <location>
            <begin position="1406"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="12">
        <location>
            <begin position="1697"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1697"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1773"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1281"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1969" mass="219205" checksum="809CE41B5C82A222" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PA83</accession>
    <name>A0A151PA83_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCAN box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0021560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PA83"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888:SF1">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46888">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN box" evidence="2">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO45952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="182" mass="20878" checksum="0967D0EF718FB093" modified="2016-06-08" version="1">MTKDDDPEAYIEAFEWTAIQTGLDRSQWDHQLGALVIDEAQAAYRALSREEAQDYEAVKAAILYRLEISPESHRQAFRACKLRESKQPQGLLQTLRDALQKWLPVGKFDRAEVLDQILLEKFLWDLEEDTQRWVRRHQPQSSEEALCLAEAFSNSEKEKGSGRGFWVSRESSGGRGRKPGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAR3</accession>
    <name>A0A151PAR3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0021734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO46186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PAR3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="11986" checksum="1AB15871AA74F932" modified="2016-06-08" version="1">MTGWGPKIGVPKLSMLRPRKLRTGSDHGYSLANCGPPCGAPQPEFPAGIQVTVTLFQDEEKGGKGDVYATPASRVHSRTWSYFGAQLGSCGGDSMVQSQGKAMICNYMLQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PBQ5</accession>
    <name>A0A151PBQ5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000499">
        <property type="protein sequence ID" value="KYO46511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PBQ5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="116" mass="12799" checksum="917C66A618E9939F" modified="2016-06-08" version="1">MLSLHTKLQKTVMQKPIVPEKCVAMAMIKLATPTSLRKCCKSVQHGPLHCWESDQIELLVASRGSNLIILKELRGSTLEKAAGLLTTLGPQRTNCISKEAVMQSRMLSGALIKIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCW7</accession>
    <name>A0A151PCW7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">5-hydroxytryptamine receptor 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HTR5A</name>
        <name evidence="12" type="ORF">Y1Q_0014510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCW7"/>
    <dbReference type="STRING" id="8496.A0A151PCW7"/>
    <dbReference type="eggNOG" id="KOG3656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF202">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO46946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="265" mass="30242" checksum="E51C1D379D1F2249" modified="2016-06-08" version="1">MPLSLVHELAGRRWRLGRPLCQAWVSVDVLCCTASIWNVAAIALDRYWSITRHLHYTLRARRRLSNLMIGLAWALSAVISLAPLLFGWGETYSAGSQQCQVSREPSYAVFSTFGAFYVPLAVVLFVYWKIYKAAKFRIGSRKSNSITPLSPGALQVKEASQQPQMVFTVRHATVTFQTDGDTWREQKEKKAALMVGILIGVFVLCWIPFFITELINPLCSCDIPPLWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFRNLFSRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PE37</accession>
    <name>A0A151PE37_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0010070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000473">
        <property type="protein sequence ID" value="KYO47288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PE37"/>
    <dbReference type="STRING" id="8496.A0A151PE37"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000269">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO47288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="217" mass="25204" checksum="0FE7ADD5CA5C8205" modified="2016-06-08" version="1">MCWNIGRTAYLHTISSSKLLELVCIDFLTIETDRKNISNVLVVTDHFTRYAQAYPTRDQRATTVAKVLWEKYFVVYGLPEQIHSNQGRDFESHLLREIFQMAGIRKSRTTPYHPQGDPQPERFNRTLINMLGTLRNEQKDCWSQHLAFLVHVYNATRNDATGASPYSLMFGREPRLPIDLCFGVAKDQGESESYGQYAQKLRERLRRAYRLAMEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PFW3</accession>
    <name>A0A151PFW3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Sodium-coupled neutral amino acid symporter 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Amino acid transporter A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Solute carrier family 38 member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">System A amino acid transporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">System A transporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">System N amino acid transporter 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="primary">SLC38A2</name>
        <name evidence="35" type="ORF">Y1Q_0019762</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29283"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:29285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:71383"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:71385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:68236"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:68238"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:71583"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:71585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29263"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:29265"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:68240"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:68242"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:68244"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:68246"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:28969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29575"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:29577"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69999"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:70001"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:68228"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:68230"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000416">
        <property type="protein sequence ID" value="KYO47675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260909.1">
        <property type="nucleotide sequence ID" value="XM_006260847.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019348391.1">
        <property type="nucleotide sequence ID" value="XM_019492846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PFW3"/>
    <dbReference type="STRING" id="8496.A0A151PFW3"/>
    <dbReference type="GeneID" id="102574343"/>
    <dbReference type="KEGG" id="amj:102574343"/>
    <dbReference type="CTD" id="54407"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="PhylomeDB" id="A0A151PFW3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF207">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID SYMPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="34">
        <location>
            <begin position="71"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00036787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00039205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00041835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00041859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00041916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00042516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00042868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KYO47675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="509" mass="56244" checksum="C119AA0C9126961A" modified="2016-06-08" version="1">MTKAEMGKFNISPDEDSSSYSSNSNDFSYSYPTKPTAMKSHYVDMDPENQNFLLESNLGKKKYETEYHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFVILLIFVSMFSLYSVHLLLKTANEGGSLLYEQLGLKAFGLAGKLAASGSITMQNIGAMSSYLFIVKYELPLVIKAFMNIEESTGEWYLNGDYLVILVSLLLILPLSLLKNLGYLGYTSGFSLLCMVFFLIVVIWKKFQIPCPMDHDLVNTTLNGTVTHSAIAATVATAVVQNFTSDDMCTPKYFIVNSQTVYAVPILTFSFVCHPAILPIYEELKGRSRRRMMKVSNVSFFAMFLMYLLAALFGYLTFYRNVEPELLHTYSAVLGTDVVLLIVRLAVLLAVTLTVPVVIFPIRSSITQLLCASKEFSWMRHCLITVSLLVFTNVLVIFVPTIRDIFGFIGASAAAMLIFILPSAFYIKLVKKEPIKSVQKIGAILFLLAGILVMTGCMTLIILDWTHNSGSDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHE1</accession>
    <name>A0A151PHE1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MSANTD3</name>
        <name evidence="1" type="ORF">Y1Q_0022633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000190">
        <property type="protein sequence ID" value="KYO48428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHE1"/>
    <dbReference type="eggNOG" id="ENOG502RFDD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="83" mass="9670" checksum="C1F18554E4E8012F" modified="2016-06-08" version="1">MMPEQMYFLQSPPEEDFEYQPDTSNQVSFVVSNKELCDEERELQVGKNEGHHEGTISVTNLQRREVRPFNKMVDGEDAYVLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHY4</accession>
    <name>A0A151PHY4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Acetyl-coenzyme A thioesterase</fullName>
            <ecNumber evidence="5">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Acyl-CoA thioester hydrolase 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Acyl-coenzyme A thioesterase 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytoplasmic acetyl-CoA hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ACOT12</name>
        <name evidence="21" type="ORF">Y1Q_0004048</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:20290"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>butanoyl-CoA + H2O = butanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:40112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHY4"/>
    <dbReference type="STRING" id="8496.A0A151PHY4"/>
    <dbReference type="eggNOG" id="KOG2763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151PHY4"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000029">
        <property type="entry name" value="Acyl-CoA thioesterase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000023">
        <property type="entry name" value="Acyl-CoA thioesterase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000011">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF3">
        <property type="entry name" value="ACETYL-COENZYME A THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="20">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="20">
        <location>
            <begin position="180"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="19">
        <location>
            <begin position="363"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO48649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="590" mass="66498" checksum="18373559380BE5B5" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ00</accession>
    <name>A0A151PJ00_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="11">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Y1Q_0004136</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PJ00"/>
    <dbReference type="STRING" id="8496.A0A151PJ00"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000001">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000013">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF10">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007587092" description="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="VIP1 N-terminal" evidence="14">
        <location>
            <begin position="75"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="929"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="946"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1240"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1255"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO48765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1276" mass="143748" checksum="3EB16888C17C417B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PK79</accession>
    <name>A0A151PK79_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Interleukin-18-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">IL18BP</name>
        <name evidence="3" type="ORF">Y1Q_0011108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000012">
        <property type="protein sequence ID" value="KYO49165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PK79"/>
    <dbReference type="STRING" id="8496.A0A151PK79"/>
    <dbReference type="KEGG" id="amj:106739627"/>
    <dbReference type="OrthoDB" id="9904367at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042007">
        <property type="term" value="F:interleukin-18 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039681">
        <property type="entry name" value="IL18BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055139">
        <property type="entry name" value="IL18BP-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14292">
        <property type="entry name" value="INTERLEUKIN-18-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14292:SF2">
        <property type="entry name" value="INTERLEUKIN-18-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22009">
        <property type="entry name" value="YLDV-IL18BP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007587106" evidence="1">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO49165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="158" mass="17128" checksum="B7FBBDB93425211D" modified="2016-06-08" version="1">MCSPGADPRSAGAWLPLVLLCGCVQLCRTDASSKLLPEIIYPLKPLPRPALGANFSVSCEAKSAFRDMTIMYWLANLSFVEKLYPNGAVQEGAVRKEPTGTGVVMQRELRFKAFSNKDLNTHFMCVVKNPAGVATTTLQWQPETAAGTEGPVQDSLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYS3</accession>
    <name>A0A151LYS3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BTG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">B-cell translocation gene 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BTG1</name>
        <name evidence="7" type="ORF">Y1Q_0020038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Anti-proliferative protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BTG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006258271.1">
        <property type="nucleotide sequence ID" value="XM_006258209.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYS3"/>
    <dbReference type="STRING" id="8496.A0A151LYS3"/>
    <dbReference type="GeneID" id="102568514"/>
    <dbReference type="KEGG" id="amj:102568514"/>
    <dbReference type="CTD" id="694"/>
    <dbReference type="eggNOG" id="KOG4006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="PhylomeDB" id="A0A151LYS3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.90:FF:000003">
        <property type="entry name" value="BTG1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF30">
        <property type="entry name" value="PROTEIN BTG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00960">
        <property type="entry name" value="BTG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Anti-proliferative protein" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO17419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="170" mass="19231" checksum="F9841EAE3DAEDA03" modified="2016-06-08" version="1">MHPALYTRASMIREIAAAVGFISKFLRTKGLMNERQLQTFNQSLQELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFQLLPSELTLWVDPYEVSYRIGEDGSICVLYEAAPAGSSQNNTNMQMVDSRISCKEELLLGRTSPSKSYNMMTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZ74</accession>
    <name>A0A151LZ74_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="32">Diacylglycerol kinase</fullName>
            <shortName evidence="32">DAG kinase</shortName>
            <ecNumber evidence="32">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="37" type="ORF">Y1Q_0020302</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="29">Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43428"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18155"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:78227"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:43429"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63324"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:72859"/>
            <dbReference type="ChEBI" id="CHEBI:82929"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:63325"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52595"/>
            <dbReference type="ChEBI" id="CHEBI:73332"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:44073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40403"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:77184"/>
            <dbReference type="ChEBI" id="CHEBI:77186"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:40404"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40407"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:77185"/>
            <dbReference type="ChEBI" id="CHEBI:77187"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40408"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75936"/>
            <dbReference type="ChEBI" id="CHEBI:78385"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41672"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:34115"/>
            <dbReference type="ChEBI" id="CHEBI:77580"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:64839"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:43417"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40323"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:40324"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:77593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:63329"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>a 1-O-alkyl-sn-glycerol + ATP = a 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15850"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58014"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.93"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:16938"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="31">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 32">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="37">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="32"/>
    <dbReference type="EMBL" id="AKHW03006970">
        <property type="protein sequence ID" value="KYO17569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZ74"/>
    <dbReference type="STRING" id="8496.A0A151LZ74"/>
    <dbReference type="eggNOG" id="KOG1169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151LZ74"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047649">
        <property type="term" value="F:alkylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20799">
        <property type="entry name" value="C1_DGK_typeI_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20890">
        <property type="entry name" value="C1_DGKalpha_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000017">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000003">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000039">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000003">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.110">
        <property type="entry name" value="Diacylglycerol kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047469">
        <property type="entry name" value="C1_DGKalpha_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029477">
        <property type="entry name" value="DAG_kinase_typeI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038199">
        <property type="entry name" value="DGK_typeI_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF38">
        <property type="entry name" value="DIACYLGLYCEROL KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14513">
        <property type="entry name" value="DAG_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14 32" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 32" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 32" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 32" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="36">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="36">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="34">
        <location>
            <begin position="207"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="34">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="35">
        <location>
            <begin position="377"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="33">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00034624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00034636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00034638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00034647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00045593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="KYO17569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="742" mass="82460" checksum="550A0E070A91D9AB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZJ8</accession>
    <name>A0A151LZJ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006878">
        <property type="protein sequence ID" value="KYO17674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZJ8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO17674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8234" checksum="37AE53A840B02FC5" modified="2016-06-08" version="1">MQHFPVQLFSVSPGNRCIAFLSHSLACFLLMCHASNQVKLNQGVPERPYRQRENHCTLRYSTWRLAQEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M308</accession>
    <name>A0A151M308_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription cofactor vestigial-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">VGLL2</name>
        <name evidence="7" type="ORF">Y1Q_0018879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vestigial family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M308"/>
    <dbReference type="eggNOG" id="ENOG502QS1A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011520">
        <property type="entry name" value="Vg_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950:SF17">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07545">
        <property type="entry name" value="Vg_Tdu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO18899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="283" mass="30273" checksum="F8FDCC209A6829EF" modified="2016-06-08" version="1">MALKLAFYSKMQEAPESTSSASTSSASSSFSSHAPPASIKEEDASPEKEQPPEAEYINSRCVLFTYFQGDISAVVDEHFSRALSQPSSYSPSSTKASRSSSSWRDGSFPMSQRSFPPSFWNSAYQASASLSSSLGSPLATAHSELPFTSADPYAPTALHGHLHQGSTEPWHPAHHHHHHHHHPYLGTQGSAYPRPAAVHDVYGPHFDPRYSSLLVPTASVRPPRLTPAPGSPQCELGKGEPAAPTAWTTPAPFPSPTGDMAQSISLNVDTACRYAFCGGSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5F8</accession>
    <name>A0A151M5F8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centrosomal protein of isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CEP128</name>
        <name evidence="2" type="ORF">Y1Q_0021031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006558">
        <property type="protein sequence ID" value="KYO19757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5F8"/>
    <dbReference type="STRING" id="8496.A0A151M5F8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026652">
        <property type="entry name" value="CEP128"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46657">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 128 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46657:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 128 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="686"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO19757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="735" mass="88207" checksum="EBD5640D02C0DA85" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5K9</accession>
    <name>A0A151M5K9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epiplakin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006541">
        <property type="protein sequence ID" value="KYO19803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5K9"/>
    <dbReference type="STRING" id="8496.A0A151M5K9"/>
    <dbReference type="eggNOG" id="KOG0516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990254">
        <property type="term" value="F:keratin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045110">
        <property type="term" value="P:intermediate filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF21">
        <property type="entry name" value="EPIPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40424" checksum="3D6735A618D91CB3" modified="2016-06-08" version="1">MALSTDTVHGEGDGKWEKTLKATVVDVPAGEFQGKKVSVWDLLFSKYFPEAERKELLELYRGGVLTLEQISTVVTTIVRKTETQGGKLIGEEESPSAETLIALKAEDAHSQEEEDWEKTLKVTAVDVPVGEFQGKKVSVWDLLFSKYFPEAERKEVLELYHRGVLTLDQVVTVVTSIVTKVEAAGGKLEAEETSPSSETLMVLNTEADHGQGAENWEKALRATAVDVPVGKFQERKVSVWELLFSRHVPEERRQELLGRFRAGALTVQGLFTILSTVIAHGNLAVSQPRTLDLLCSEATCVTVRPFQGHTMSVWDLLSSQHISEYKRETSLDTYGAGRLIINKITVTTTVTSSPAGQRGNRRHCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6V4</accession>
    <name>A0A151M6V4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sprouty-like protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SPRY4</name>
        <name evidence="2" type="ORF">Y1Q_0010788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sprouty family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263454.1">
        <property type="nucleotide sequence ID" value="XM_006263392.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006263455.1">
        <property type="nucleotide sequence ID" value="XM_006263393.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6V4"/>
    <dbReference type="STRING" id="8496.A0A151M6V4"/>
    <dbReference type="GeneID" id="102577055"/>
    <dbReference type="KEGG" id="amj:102577055"/>
    <dbReference type="CTD" id="81848"/>
    <dbReference type="eggNOG" id="ENOG502QQ4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10038884at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M6V4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051192">
        <property type="entry name" value="Sprouty_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365:SF6">
        <property type="entry name" value="PROTEIN SPROUTY HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365">
        <property type="entry name" value="SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="299" mass="33239" checksum="0A2B40553821A7AD" modified="2016-06-08" version="1">MEPRIPHNITVVPNSVMVQPLLDGRIPYGRLQHPLTILPIDQMKTIHIENDYTDNPTLAQLATQKRPRGPYEPTLISQHLQRCEQDVTHPWISFSGRPSSISSSSSTSSDQRLLDHMAPAPVADQSSPRAVRIQPKVINCKPLDLKGPMSQELDKHFLLCEACGKCKCKECALPRTLPSCWVCNQECLCSAQNLVNYSTCMCLVKGVFYHCTNEDDEGTCADHPCSCSHSNCCARWSFMSALSLVLPCLLCYLPATGCVKLSQRCYDQVSRPGCRCKNTNSVICKSVPDGKTSRPEKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M765</accession>
    <name>A0A151M765_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Interleukin 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IL9</name>
        <name evidence="2" type="ORF">Y1Q_0010844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M765"/>
    <dbReference type="STRING" id="8496.A0A151M765"/>
    <dbReference type="GeneID" id="109280876"/>
    <dbReference type="KEGG" id="amj:109280876"/>
    <dbReference type="OrthoDB" id="9319231at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M765"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005140">
        <property type="term" value="F:interleukin-9 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020447">
        <property type="entry name" value="IL-9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16926">
        <property type="entry name" value="INTERLEUKIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16926:SF1">
        <property type="entry name" value="INTERLEUKIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007584761" evidence="1">
        <location>
            <begin position="17"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO20311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="131" mass="15074" checksum="1708F289573128FA" modified="2016-06-08" version="1">MLLYILFSCLLLVVQARTICRVRETIDLTNELLVKLEDCECTETNHNSCLCLPIPNNACLTCFETHNEEIEEKLSTIGSDGRRLYRYLQQLRNWKLCAPLFNCNETCDASPGNMMTFLTTVRAALQKLQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7D8</accession>
    <name>A0A151M7D8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0005899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006405">
        <property type="protein sequence ID" value="KYO20448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M7D8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00021">
        <property type="entry name" value="PRORICH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO20448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="162" mass="17397" checksum="B4791F4151E8B6AB" modified="2016-06-08" version="1">MATVHSQDTNPYKSTLISTASLSTWLLIHSLLFTRQVSLNRRTMSYSDQQQCKQVVCPPPVCPPTKCPPVCPPQKCPPPDCPPPKAYESFPSLRLLIHLTPHPLPPVRLTGISELKNHVLPQPAAMQAGCVSSTSDSSPEVSSTAVSSTKVPSIEVSSTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M815</accession>
    <name>A0A151M815_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein Di-Ras2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DIRAS2</name>
        <name evidence="11" type="ORF">Y1Q_0012539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Displays low GTPase activity and exists predominantly in the GTP-bound form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006358">
        <property type="protein sequence ID" value="KYO20647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019333770.1">
        <property type="nucleotide sequence ID" value="XM_019478225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M815"/>
    <dbReference type="STRING" id="8496.A0A151M815"/>
    <dbReference type="GeneID" id="106737216"/>
    <dbReference type="KEGG" id="amj:106737216"/>
    <dbReference type="CTD" id="54769"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04140">
        <property type="entry name" value="ARHI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO20647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="199" mass="22557" checksum="62230B7545C83F28" modified="2016-06-08" version="1">MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRESYIPTIEDTYRQVISCDKSICTLQITDTTGSHQFPAMQRLSISKGHAFILVYSVTSRQSLEELKPIYEQICQIKGDVENIPIMLVGNKSDESQNREVESSEGDAMAKKWKCAFMETSAKLNHNVKELFQELLNLEKRRTVSLQIDGKKSKQQKRKEKLKGKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MA13</accession>
    <name>A0A151MA13_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0001587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MA13"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9583" checksum="CD1D62B955654C22" modified="2016-06-08" version="1">MEKAFEYISSQAVLCSTSESADVNSGQMAVFPCAQTCVGCTQTIANYCQEATPCVLSFEMACTFFETNLATCWGFFYSKGLSNFYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MB56</accession>
    <name>A0A151MB56_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARHGAP1</name>
        <name evidence="6" type="ORF">Y1Q_0000467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261450.1">
        <property type="nucleotide sequence ID" value="XM_006261388.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014457732.1">
        <property type="nucleotide sequence ID" value="XM_014602246.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MB56"/>
    <dbReference type="STRING" id="8496.A0A151MB56"/>
    <dbReference type="GeneID" id="102567827"/>
    <dbReference type="KEGG" id="amj:102567827"/>
    <dbReference type="CTD" id="392"/>
    <dbReference type="eggNOG" id="KOG4406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MB56"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001136">
        <property type="term" value="P:negative regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04404">
        <property type="entry name" value="RhoGAP-p50rhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000024">
        <property type="entry name" value="Rho GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000007">
        <property type="entry name" value="rho GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049592">
        <property type="entry name" value="ARHGAP1_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF6">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="64"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="245"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO21758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="437" mass="50542" checksum="5E3EB3DFD0151F43" modified="2016-06-08" version="1">MATDPLSELQEDQTLEDTNQSLSQLKLASIDDRTWPADEVPVFPRSEDSGGSPESITHLKWDDPYYDIARHHIVEVAGDDNFGRKVIVVSACRMPPSHQLDHTKLLGYLKFTLDQYVESDYTLVYLHHGLTSENKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYVNFLSELEEYVKVEQLGIPSQVLKYDEYLKSQQKPSQVPQKPTPPRPPLPNQQFGVSLQHLREKSPDQDPVPRVVRETIGHLQEHALVTEGVFRRSANTQVVREVQQKYNMGMPVHFEQYEAVHLPAVILKTFLRELPEPLLTFNLYSHVVNFQNVEEINRVDTVRKILQTLPDENYQVLHLLTAFLVQVSDNSDVNKMTNTNLAVVFGPNLLWDKDVAITLKAINPINTFTKFLLDHQRELFPDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MCR6</accession>
    <name>A0A151MCR6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">complement subcomponent C1r</fullName>
            <ecNumber evidence="4">3.4.21.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="primary">C1R</name>
        <name evidence="34" type="ORF">Y1Q_0002923</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens. Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R. Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway. It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).</text>
            <dbReference type="EC" id="3.4.21.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Core component of the complement C1 complex, a calcium-dependent complex composed of 1 molecule of the C1Q subcomplex, 2 molecules of C1R and 2 molecules of C1S. The C1Q subcomplex is composed 18 subunits: 3 chains of C1QA, C1QB, and C1QC trimerize to form 6 collagen-like triple helices connected to six globular ligand-recognition modules. Within the C1 complex, C1R is a dimer of identical chains, each of which is activated by cleavage into two chains, heavy and light, connected by disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="27">The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.41" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MCR6"/>
    <dbReference type="STRING" id="8496.A0A151MCR6"/>
    <dbReference type="eggNOG" id="KOG3627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000040">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000035">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000059">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000016">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000006">
        <property type="entry name" value="Mannan-binding lectin serine protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000012">
        <property type="entry name" value="mannan-binding lectin serine protease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024175">
        <property type="entry name" value="Pept_S1A_C1r/C1S/mannan-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF25">
        <property type="entry name" value="COMPLEMENT C1R SUBCOMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001155">
        <property type="entry name" value="C1r_C1s_MASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="17 28" id="KW-0106">Calcium</keyword>
    <keyword evidence="19" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="20 26 29" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22 27" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="18" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11 28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 27" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9 30" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="CUB" evidence="31">
        <location>
            <begin position="38"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="31">
        <location>
            <begin position="218"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="33">
        <location>
            <begin position="332"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="33">
        <location>
            <begin position="399"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="32">
        <location>
            <begin position="484"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="25">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="25">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="25">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="28">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="(3R)-3-hydroxyasparagine" evidence="27">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK2" evidence="27">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26 29">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="334"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="401"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (between heavy and light chains)" evidence="26">
        <location>
            <begin position="471"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="688"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00093536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR001155-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="KYO22326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="744" mass="83563" checksum="966EDB24D7ABCDEE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MD12</accession>
    <name>A0A151MD12_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromodomain-helicase-DNA-binding protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CHD1L</name>
        <name evidence="20" type="ORF">Y1Q_0002999</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with nucleosomes; interacts with the acidic patch of histones. Interacts (via macro domain) with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated). Interacts with CIAO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006231">
        <property type="protein sequence ID" value="KYO22418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006261538.2">
        <property type="nucleotide sequence ID" value="XM_006261476.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MD12"/>
    <dbReference type="STRING" id="8496.A0A151MD12"/>
    <dbReference type="GeneID" id="102568987"/>
    <dbReference type="KEGG" id="amj:102568987"/>
    <dbReference type="CTD" id="9557"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MD12"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18006">
        <property type="entry name" value="DEXHc_CHD1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03331">
        <property type="entry name" value="Macro_Poa1p-like_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.220.10:FF:000004">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000037">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000607">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031053">
        <property type="entry name" value="ALC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="48"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="341"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO22418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="887" mass="100741" checksum="5251749891F46BD9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFW7</accession>
    <name>A0A151MFW7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFW7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO23422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="112" mass="12740" checksum="E0DC0F3EC17B6DB1" modified="2016-06-08" version="1">MMRELDNCRVKWNRSPVSVCAGSKRKNIPSRNLKIAEQDYWLPAPTCFRETADISQHHEEGTSAKPSSRRRRTQGMQVLPGMLQGPQAILTKKSLETEPNEEKEGNSECQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MGL2</accession>
    <name>A0A151MGL2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0002270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006178">
        <property type="protein sequence ID" value="KYO23633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MGL2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585169" evidence="2">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO23633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="144" mass="16003" checksum="29EFB18D74520E3A" modified="2016-06-08" version="1">MKSKALILQMFATLLHFTQAVHTQNFNLWVQSTFLLVSKARKEPVISKPGKGNIGKRVSHRPEKLDLAGRPGGIIAAQGISVCSSFCYLTMAHTFIFMLTSMWISCYNLFFMRIPLHAHADPVGSSIRDHHGTQGQCSSAEDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHU7</accession>
    <name>A0A151MHU7_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">N-acetylglucosamine-1-phosphotransferase subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GlcNAc-1-phosphotransferase subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GNPTG</name>
        <name evidence="15" type="ORF">Y1Q_0014595</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer; disulfide-linked. Hexamer of two alpha (GNPTAB), two beta (GNPTAB) and two gamma (GNPTG) subunits; disulfide-linked. The alpha and/or the beta subunits of the enzyme constitute the catalytic subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006130">
        <property type="protein sequence ID" value="KYO24098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHU7"/>
    <dbReference type="STRING" id="8496.A0A151MHU7"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000018">
        <property type="entry name" value="N-acetylglucosamine-1-phosphotransferase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="14">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DMAP1-binding" evidence="13">
        <location>
            <begin position="119"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO24098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="258" mass="29836" checksum="126DEFF6A4E958E4" modified="2016-06-08" version="1">MSGPVHLFRLAGKCFSFVESMYKYEFCPFHNVTQHEQTFRWNAYSGILGIWHEWEIDNNTFVGMWMREGDSCETKSRQTKVLLVCGKSNKLAHVSEPSTCVYSLTFETPLVCHPHSLLVYPTLPEALRMKWDEAEQSLYDELITEQGYKKMLKEILEEAGLLRATEEKEIEIQNKKTLNLDFKTVEKCNKEYEQLSKEIKKLKHLLTQHGIVYDRNSAENTSAEHSVSKLLTAKPTILNGSKDNEHLRGDTGIWNDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MIV5</accession>
    <name>A0A151MIV5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0002068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006071">
        <property type="protein sequence ID" value="KYO24447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MIV5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="10754" checksum="62D14ED37D1B671C" modified="2016-06-08" version="1">MDEGKSGGKGKEIGKENCSETGMMESRVFKVLGLQPCENSEVDSLALYSELIRAGLEPAGLLYPRLYRKQSAAKLQYIISERARLNCFSPCLFLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MJG8</accession>
    <name>A0A151MJG8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0017761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006032">
        <property type="protein sequence ID" value="KYO24656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MJG8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO24656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="87" mass="9643" checksum="F7818B12DDA0EC2F" modified="2016-06-08" version="1">MLPPLCHWEGTGQKLEATRNVKVHELRVDYAGGKIIQQVCRPNGFLNMSPQSIESDGILLREIPAQFSHKESTDMMVGPTPDDIGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MK24</accession>
    <name>A0A151MK24_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane and coiled-coil domains protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMCC1</name>
        <name evidence="10" type="ORF">Y1Q_0023760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005996">
        <property type="protein sequence ID" value="KYO24888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014461007.1">
        <property type="nucleotide sequence ID" value="XM_014605521.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MK24"/>
    <dbReference type="STRING" id="8496.A0A151MK24"/>
    <dbReference type="GeneID" id="106737153"/>
    <dbReference type="CTD" id="23023"/>
    <dbReference type="eggNOG" id="KOG3850">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10072335at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140285">
        <property type="term" value="P:endosome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097750">
        <property type="term" value="P:endosome membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF11">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10267">
        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO24888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="640" mass="70981" checksum="F5469C4C7F482225" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLJ2</accession>
    <name>A0A151MLJ2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein c-Fos</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cellular oncogene fos</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FOS</name>
        <name evidence="8" type="ORF">Y1Q_0020770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Fos subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005800">
        <property type="protein sequence ID" value="KYO25394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLJ2"/>
    <dbReference type="STRING" id="8496.A0A151MLJ2"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14721">
        <property type="entry name" value="bZIP_Fos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000006">
        <property type="entry name" value="fos-related antigen 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF4">
        <property type="entry name" value="PROTEIN C-FOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="293"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="291"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO25394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="530" mass="56550" checksum="6CAA252C063901E0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLP0</accession>
    <name>A0A151MLP0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TUFM</name>
        <name evidence="14" type="ORF">Y1Q_0016052</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ataxin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005789">
        <property type="protein sequence ID" value="KYO25446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLP0"/>
    <dbReference type="STRING" id="8496.A0A151MLP0"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03706">
        <property type="entry name" value="mtEFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000002">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000068">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="59"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="673"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO25446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="779" mass="85430" checksum="5DF3273FA04E0BCF" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MME7</accession>
    <name>A0A151MME7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Geminin coiled-coil domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GMNC</name>
        <name evidence="6" type="ORF">Y1Q_0013770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005724">
        <property type="protein sequence ID" value="KYO25609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MME7"/>
    <dbReference type="STRING" id="8496.A0A151MME7"/>
    <dbReference type="eggNOG" id="ENOG502RE7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GemC1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059237">
        <property type="entry name" value="GemC1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372">
        <property type="entry name" value="GEMININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13372:SF2">
        <property type="entry name" value="GEMININ COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
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            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO25609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="359" mass="39536" checksum="600BAA5350E5AB76" modified="2016-06-08" version="1">MYKQAPCVPLPGPIALHFPDTVINHSPLDRALTCLEMKLSSPFLGSPAASVDVSKETRVSFWAAGLPDNSGEGQPGDPFCDLDFAGQDDVWPGDQLSSQLYRNKQLQDTLLQKEEELARLHEENNNLRQYLNSALIKCLEEKAKKLLSGSSQRDHAIFRGGKRKVRENDCFAPPESPPLAKARRNLFSEFTACEESPHPAVDSWVLQTLGLKDIDTIDESVSANYSALASELGKDPYCPQPVEAMDYDSAEDPTALYGCEPLTRTPSTASPCKEVTPYLPPLSSAPCASSSGHGDVPFPAYGLPYFSQDVSRNKTEVAFTTSVSPHRNVKTHTFQQGQAFVRRDDDGGWKFTWVPKQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNE2</accession>
    <name>A0A151MNE2_ALLMI</name>
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        <submittedName>
            <fullName evidence="6">Protein FAN</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="6" type="ORF">Y1Q_0003817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006269596.1">
        <property type="nucleotide sequence ID" value="XM_006269534.4"/>
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    <dbReference type="AlphaFoldDB" id="A0A151MNE2"/>
    <dbReference type="STRING" id="8496.A0A151MNE2"/>
    <dbReference type="GeneID" id="102572640"/>
    <dbReference type="KEGG" id="amj:102572640"/>
    <dbReference type="CTD" id="8439"/>
    <dbReference type="eggNOG" id="KOG1786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MNE2"/>
    <dbReference type="Proteomes" id="UP000050525">
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    </dbReference>
    <dbReference type="CDD" id="cd06071">
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    <dbReference type="CDD" id="cd00200">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="neurobeachin isoform X1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000336">
        <property type="entry name" value="Neutral sphingomyelinase activation-associated factor"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
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    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
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    </dbReference>
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        <property type="entry name" value="GRAM"/>
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    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
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        <property type="match status" value="1"/>
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    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
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            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
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        <location>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
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    </feature>
    <feature type="repeat" description="WD" evidence="3">
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="882"/>
            <end position="917"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO26057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="917" mass="104437" checksum="5BD49B80AD92566C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNW2</accession>
    <name>A0A151MNW2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
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            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNW2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="107" mass="11367" checksum="1A4769B053B1997B" modified="2016-06-08" version="1">MLAQGKAKLSMQLREQLLPGGPFYLLESVTWASPSPHSGVHSSGLPQQFLDLDKGTKKLGGMMLKAKLGQVHSSFMGSKADERKGSPGGEEELVAPASTVRYSLDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNW7</accession>
    <name>A0A151MNW7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005656">
        <property type="protein sequence ID" value="KYO26206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNW7"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="10365" checksum="80BEF8430D22FE93" modified="2016-06-08" version="1">MRDNKITSFQKTSEGCHNSNKSLHLSESLLVILDDFCPEGIQMNTTACTLVDYTSCIFFDEKLSTQLGICRYVEDGGEEGKRAISGTWSTSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MP04</accession>
    <name>A0A151MP04_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005608">
        <property type="protein sequence ID" value="KYO26268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MP04"/>
    <dbReference type="STRING" id="8496.A0A151MP04"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="72" mass="8093" checksum="9083F1D729973CB1" modified="2016-06-08" version="1">MDVEGKDPLSIAMDMTNADIVTLLRLAKMREAEVAQGQAGDETYLDIFRDFSLMASDNPEMLTRRDLKLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQC9</accession>
    <name>A0A151MQC9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA (Cytosine(38)-C(5))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRDMT1</name>
        <name evidence="6" type="ORF">Y1Q_0019092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006265920.1">
        <property type="nucleotide sequence ID" value="XM_006265858.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQC9"/>
    <dbReference type="STRING" id="8496.A0A151MQC9"/>
    <dbReference type="GeneID" id="102565207"/>
    <dbReference type="KEGG" id="amj:102565207"/>
    <dbReference type="CTD" id="1787"/>
    <dbReference type="eggNOG" id="KOG0919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MQC9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00315">
        <property type="entry name" value="Cyt_C5_DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000285">
        <property type="entry name" value="tRNA (cytosine(38)-C(5))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO26600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="400" mass="45748" checksum="0A81CEC282135B61" modified="2016-06-08" version="1">MEPLRALELFSGLGGMHQALRESCIPAEVVAAVDVNTTANEVYKHNFPSTPLWAKTIEGITLKEFNRLSFDMILMSPPCQPFTRIGLQGDVSDPRTKSFIYILDILPRLERLPKYILLENVKGFETSSARNEFVQTLEACGFKYQEFLLSPTCLGVPNSRLRYFLIAKLHSEPFSFQASDQILTYFPDQESNNSVKYKVPLGLEKDNSSTLTEEENLVPNSGFDCGERQCSPKEAFLFKLETMEEMKRKQNQDNDFSMQVLKDFLEGDSEEMSQYYLPPKSLLRYAFLLDIVKPTCRRSTCFTKGYGHYVEGTGSVLQTAEDVQLESVFKFIETLSEEEKLKKLSTLKLRYFTPREIANLHGFPPEFGFPDKITVKQRYRLLGNSLNVHIVAKLISLLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRP8</accession>
    <name>A0A151MRP8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0008895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005400">
        <property type="protein sequence ID" value="KYO27080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRP8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="96" mass="10385" checksum="28733785F0FA72AB" modified="2016-06-08" version="1">MTQQSTLEETDVNFTEPEPGNAADKELDTDKCKQCPKVPARSQEGCKGLGRAKSQLRLQIGIHRSTRILPAHVAHEGSLLRGEGVARSQLQGSSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSX9</accession>
    <name>A0A151MSX9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSX9"/>
    <dbReference type="STRING" id="8496.A0A151MSX9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026314">
        <property type="entry name" value="YLP_motif_con_p1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413">
        <property type="entry name" value="YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413:SF0">
        <property type="entry name" value="YLP MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7569" checksum="11A06CD1CEAE0ED9" modified="2016-06-08" version="1">MDKAFCFDKDKLDGLRTGAKRKRDWEAIASRMEDYLQLPDDYDTRASEPGKKREMPCEVGPGRTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTA9</accession>
    <name>A0A151MTA9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0005291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005127">
        <property type="protein sequence ID" value="KYO27740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTA9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11428" checksum="F2358825D8006F24" modified="2016-06-08" version="1">MQKADRYTEKAVERFKRFKSNTAPPLRRSPPETLQQLRSSPPTPSIAGANFKSLPLWVSLACLKLLPEIRSALGIPEAKFPLHCPGRQISQSKFVFYYHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTL9</accession>
    <name>A0A151MTL9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Muscarinic acetylcholine receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CHRM1</name>
        <name evidence="19" type="ORF">Y1Q_0006892</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with GPRASP2. Interacts with TMEM147.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005076">
        <property type="protein sequence ID" value="KYO27839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTL9"/>
    <dbReference type="STRING" id="8496.A0A151MTL9"/>
    <dbReference type="eggNOG" id="KOG4220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040012">
        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046541">
        <property type="term" value="P:saliva secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17790">
        <property type="entry name" value="7tmA_mAChR_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000047">
        <property type="entry name" value="Muscarinic acetylcholine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002228">
        <property type="entry name" value="Musac_Ach_M1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF182">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 16" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 15 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0770">Synapse</keyword>
    <keyword evidence="12 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="44"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="225"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO27839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="516" mass="57388" checksum="16521FA4EB660932" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MTQ6</accession>
    <name>A0A151MTQ6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005059">
        <property type="protein sequence ID" value="KYO27890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MTQ6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="8061" checksum="E897C67B1441587D" modified="2016-06-08" version="1">MERVQDGTGAAHREKRGQGALPERLHPNLPNPALASQVFRRFTSRLPGSAWTRRSALPREKLLWSQSNEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU15</accession>
    <name>A0A151MU15_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nuclear receptor subfamily 0 group B member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0014200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR0 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO28013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MU15"/>
    <dbReference type="STRING" id="8496.A0A151MU15"/>
    <dbReference type="eggNOG" id="KOG3575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000031">
        <property type="entry name" value="Nuclear receptor subfamily 0 group B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033544">
        <property type="entry name" value="NR0B1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24081:SF11">
        <property type="entry name" value="NR LBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24081">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="10">
        <location>
            <begin position="117"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO28013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="369" mass="42132" checksum="CF3588D2B470410F" modified="2016-06-08" version="1">MAVRMVCRRKTYWKSTQEGELVARHAGMLEDCASASIRRAIAVTQDTWVGKTTPCLAMKENSLEQIKFKCLAEVLQQHSSVRTEFGCNKGTSQETFKAMASQVPAEKSEKCQCETSRPESILYQLLNKQHQNDTEWIDHYSYTPCSLPSVGCPCVDNRRVILKNPEVTCMRASEVLLKTITFIRNLPSFCDLPQEDQILLVQQCWAPLFVLGLAQERVDFELKEISSPSLLKKILLNQSLAASEELESFPHGASLAEVQKVKHFLKKFWNLDMCAKEYAYLKGIILFNPELHGLKCCPHVQTLQQEAQRTLMEFISMMYDRNLSRFSWVLGFLTSLSTVDADSIKELFFRPILGEVILNELLLETLYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MUW0</accession>
    <name>A0A151MUW0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Embryonic polyadenylate-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PABPN1L</name>
        <name evidence="7" type="ORF">Y1Q_0004540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004929">
        <property type="protein sequence ID" value="KYO28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_059569950.1">
        <property type="nucleotide sequence ID" value="XM_059713967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MUW0"/>
    <dbReference type="STRING" id="8496.A0A151MUW0"/>
    <dbReference type="GeneID" id="102560911"/>
    <dbReference type="CTD" id="390748"/>
    <dbReference type="eggNOG" id="KOG4209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12551">
        <property type="entry name" value="RRM_II_PABPN1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000311">
        <property type="entry name" value="polyadenylate-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF27">
        <property type="entry name" value="EMBRYONIC POLYADENYLATE-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO28292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="249" mass="27895" checksum="D59729B1A49F08A4" modified="2016-06-08" version="1">MSGLGAGSFFLDPSGIWWQDPMGAPVMGDSWDVVEMATLQKMDEDSDLSQLEGDSVEELEVEDPELEAIKAKVREMEEEEERLKELQAEAQSHLLMAAEAGFFFPRTAEEKIKADQRSVYVGNVDYGGTAEELESHFNSCGQINRVTILCDKFSGHPKGYAYIEFEEQSSVKVAVALDESVFRGRVIKVLPKRTNMPGISTTDRGAFRGRAQSRGGLCYGASFCRGQRAWPRGRVYRSRGRLLPWYSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV00</accession>
    <name>A0A151MV00_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="18">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Y1Q_0015983</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="18"/>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151MV00"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05036">
        <property type="entry name" value="PTKc_ALK_LTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000113">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000117">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055163">
        <property type="entry name" value="ALK/LTK-like_GRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF629">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12810">
        <property type="entry name" value="ALK_LTK_GRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="MAM" evidence="21">
        <location>
            <begin position="52"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="21">
        <location>
            <begin position="276"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="923"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1330"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1414"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1343"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1414"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1431"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="957"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KYO28383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1443" mass="157137" checksum="B9BA47A7A14AD7F4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWC6</accession>
    <name>A0A151MWC6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose-6-phosphate translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC37A4</name>
        <name evidence="8" type="ORF">Y1Q_0008115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004743">
        <property type="protein sequence ID" value="KYO28804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006266905.1">
        <property type="nucleotide sequence ID" value="XM_006266843.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWC6"/>
    <dbReference type="STRING" id="8496.A0A151MWC6"/>
    <dbReference type="GeneID" id="102567529"/>
    <dbReference type="CTD" id="2542"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061513">
        <property type="term" value="F:glucose 6-phosphate:phosphate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17343">
        <property type="entry name" value="MFS_SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000112">
        <property type="entry name" value="glucose-6-phosphate exchanger SLC37A4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000111">
        <property type="entry name" value="Solute carrier family 37 member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051337">
        <property type="entry name" value="OPA_Antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021159">
        <property type="entry name" value="Sugar-P_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00881">
        <property type="entry name" value="2A0104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43826:SF3">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00942">
        <property type="entry name" value="GLPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="13"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO28804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="429" mass="46077" checksum="174B822551779783" modified="2016-06-08" version="1">MAGYGYGYYRAVIFTAMFAGYTLYYFNRKTFSFVMPSVMAEIQLDKDDLGLITSSQSAAYAISKFISGVLSDQMSARWLFSSGLLLVGLVNVAFSWSSTVAVFSGLWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPIVAALMALSYDWRTTLSISGFICVGASFVCLALIKNEPSDVGLPSIEAGASKGKKGPSRDDSTLTELLLSPYLWVLSTGYLVVFGVKTCCTDWGQLFLIQERGQSALVGSSYMSALEIGGLVGSIAAGYLSDRAVARVGLSSYGNPRHVLLLSMMAGMSASMYLFRVTVTSESPKLWILTLGAIFGFSSYGPIALFGVIANESAPSNLCGTSHAIVALMANVGGFLAGLPFSTIAKHYSWATAFWVAEITCTISTVAFFLLRNIRTKMGRITKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWG4</accession>
    <name>A0A151MWG4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sperm-associated antigen 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004756">
        <property type="protein sequence ID" value="KYO28788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWG4"/>
    <dbReference type="STRING" id="8496.A0A151MWG4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990716">
        <property type="term" value="C:axonemal central apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026173">
        <property type="entry name" value="SPAG17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963">
        <property type="entry name" value="PF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963:SF1">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO28788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45077" checksum="09A16B149E75993A" modified="2016-06-08" version="1">MSFPNLEKSSKDLRTRAHIAELYKQAVAPQLQTSSKHSEKNWQKLSKEELPQVSQWQKKIEQHRKELDEGKYCLMAIRKKIIPPYFESELGTEFLLKQFPDLESLSKELPPFPKKERKESSLETISISSNFEFSAVSKEIHATASDFLSSLNPLSDSSSEWVQVSCSHSIAELSRAVRTSEIPFQPQTQSLMVDASGKPKKKKVNLPSSIKGCKPESKPNEKIEHPIGGRVNISSHETATKCLSGFLLIPAQVTFGVLKEGCTYATTVILKNVGVDFLRFRVKQPPPSTGLRVIYTPGPVAAGLQVELEIEIYAMVIGKEGTEGPGEISCHIEILTETETLFLPVEATVLMGRLCCPANCPYNIRALEEQHQNQQYQHTCILLNYYCINFSPINIVTQFIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MY09</accession>
    <name>A0A151MY09_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 6C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytochrome c oxidase polypeptide VIc</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COX6C</name>
        <name evidence="10" type="ORF">Y1Q_0018008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004704">
        <property type="protein sequence ID" value="KYO29382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MY09"/>
    <dbReference type="STRING" id="8496.A0A151MY09"/>
    <dbReference type="eggNOG" id="ENOG502SEI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22901">
        <property type="entry name" value="CcO_VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO29382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="105" mass="11625" checksum="D3FCEA2329E2374A" modified="2016-06-08" version="1">MRHRGACSVPGPSCGRTLRLLGDAAAAMSSLLPKPQMRGLLTRRLRFHAVGAFVFCFGSALIYKFGVAEPRKRAYTEYYKNHDPPPQIPSLQGDLTTEICLFTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1I7</accession>
    <name>A0A151N1I7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UQCRC2</name>
        <name evidence="3" type="ORF">Y1Q_0008255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1I7"/>
    <dbReference type="STRING" id="8496.A0A151N1I7"/>
    <dbReference type="GeneID" id="102566246"/>
    <dbReference type="KEGG" id="amj:102566246"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000018">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF226">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="1">
        <location>
            <begin position="53"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO30620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="457" mass="48940" checksum="2E386F94D4CC516C" modified="2016-06-08" version="1">MEGLLALTRSFSRRLYSLKVAPKVQASATKEQAKLHLQPQDLEITKLPNGLIIASLENYSPVSRIGVFIKAGSRNETPSNLGTVHLLRLASNLTTKGASSFKITRGIEAIGGSLSVISTRENMIYSVDCLRDDVDTVMEYLINVTTAPEFRPWEVTALQPQLKIDKTIAFQNLQVGVLENLHAVAYRNALANSMYCPDYAVGKITPEQLHHFVQNNFTSARMALVGIGVSQSDLKQVGEQFLNIRGGAGSSRAKAQYRGGEIREQSGNSLVHAAVVAEGAVLGSEEANAFTVLQHVLDPGPLIKRGSNITSKLFQAVAKATNLPFDASSFNVNYSDTGLFGIYVISQASAAGEVIKAAMDQVKAIAQGNITEEDVQRAKNQAKATYLLSLETTDGLLNEIGLEALVFGTHTSPAGVTQKIDSVATADIVTAAKKFVNGKKSMAATGDLGSTPFVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1V1</accession>
    <name>A0A151N1V1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cerebellar degeneration-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CDR2</name>
        <name evidence="4" type="ORF">Y1Q_0008262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N1V1"/>
    <dbReference type="GeneID" id="102561499"/>
    <dbReference type="KEGG" id="amj:102561499"/>
    <dbReference type="CTD" id="1039"/>
    <dbReference type="eggNOG" id="ENOG502QUPP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10059415at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N1V1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026079">
        <property type="entry name" value="CDR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232">
        <property type="entry name" value="CENTROCORTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232:SF1">
        <property type="entry name" value="CEREBELLAR DEGENERATION-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="188"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO30629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="457" mass="52927" checksum="CA2C4578B375F6FB" modified="2016-06-08" version="1">MLADSLVEEFELREDEPWYDQQDLQQDLHLAAELGKTLLDRNTELEESLQQMYATNQEQLQEIEYLTKQVELLRQMNDQHAKVYEQLDVTARELEDSNQKLVAESRSSQQKILSLTETIESLQTHIDDLQKQVEELKKSGRGRLNHDRAEQPRSMHSFSCLKELYDLRQYFVYDHVFAEKIASMDSQLSPMEEENENLKKAMTVLQAQLNLEKEKRVTMEEEYSLVIKENSDLEQRLVDIDLYRARAEELETEVAEMKQILQSENALNSVEKLVPESFFISFREPLERELSQSLSEGIALAVPELDKVALKRSNSETFLSSAASGDILRGHEETCIRRAEAVKQRGISVLNEVDAQYNALRVKYEELLKKCQMDEDSLKHKAVQTSKQYSKDTNLENSQFDLSVSDRESANVELTGSPTNALPEYKALFKEIFSCIKKTKQEIDEHRAKYKSLSSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2J4</accession>
    <name>A0A151N2J4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">U3 small nucleolar RNA-associated 6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0016393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2J4"/>
    <dbReference type="STRING" id="8496.A0A151N2J4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001123">
        <property type="entry name" value="UTP6 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056907">
        <property type="entry name" value="UTP6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24892">
        <property type="entry name" value="UTP6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 homolog C-terminal" evidence="9">
        <location>
            <begin position="293"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO31014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="96015" checksum="E61FF1ED193C8B37" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2X2</accession>
    <name>A0A151N2X2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0016511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004113">
        <property type="protein sequence ID" value="KYO31176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2X2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO31176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="81" mass="9450" checksum="111703706657EC1C" modified="2016-06-08" version="1">MIRMWDLAFFYCIMLPLMPCSLLLFHSRYEKREGDIQKRRDTSGRGSDSPAHSSAQWLSQVLELSNCISMPASMFAISFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3I4</accession>
    <name>A0A151N3I4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-lysine methyltransferase METTL21D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VCPKMT</name>
        <name evidence="3" type="ORF">Y1Q_0002575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004091">
        <property type="protein sequence ID" value="KYO31340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3I4"/>
    <dbReference type="STRING" id="8496.A0A151N3I4"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151N3I4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF44">
        <property type="entry name" value="PROTEIN N-LYSINE METHYLTRANSFERASE METTL21D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO31340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="144" mass="16711" checksum="CB7A8A7DE8FF6486" modified="2016-06-08" version="1">MAASLGADVTVTDLEELQDLLKLNIETNKHLLTGSIQAKVLKWGEDVTAFLPPPDYILMADCIYYEESLEPLLKTLKDLSGPDTCIICCYEQRTMGKNPEIERKYFELLQMDFELEEIPLEQHDEEYRSEDILILNIRRKKQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4F4</accession>
    <name>A0A151N4F4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Draxin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dorsal inhibitory axon guidance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dorsal repulsive axon guidance protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">DRAXIN</name>
        <name evidence="7" type="ORF">Y1Q_0006052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the draxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004073">
        <property type="protein sequence ID" value="KYO31469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006259357.1">
        <property type="nucleotide sequence ID" value="XM_006259295.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4F4"/>
    <dbReference type="STRING" id="8496.A0A151N4F4"/>
    <dbReference type="GeneID" id="102573626"/>
    <dbReference type="KEGG" id="amj:102573626"/>
    <dbReference type="CTD" id="374946"/>
    <dbReference type="eggNOG" id="ENOG502QUE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9931375at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N4F4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021528">
        <property type="term" value="P:commissural neuron differentiation in spinal cord"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021516">
        <property type="term" value="P:dorsal spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03060">
        <property type="entry name" value="Draxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029094">
        <property type="entry name" value="Draxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28610">
        <property type="entry name" value="DRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28610:SF1">
        <property type="entry name" value="DRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15550">
        <property type="entry name" value="Draxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009000298" description="Draxin" evidence="5">
        <location>
            <begin position="27"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO31469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="349" mass="39026" checksum="5FAED580208C9D23" modified="2016-06-08" version="1" precursor="true">MATSPDSSMLLLLCVLVLSDISPVSALDTSAKAKTTPENNNHFQSPELWQPPPSTGHHRRHGVVRKDRAHGAASRGQTSGEEALKLGSRPPGVEALAAVERPAALKQKKDVFLGFEFPYSERENQSPGSDRGKKQSREHRRHSRRDRLKQHRGKGPDPGLSSLYKKPEHFEEQFPNLPGEDPSSLVPTELLFTTPDTAASTEEPSALHATSPRPQVRIRQDGDVMPTLDMALFDWTDYEDLKPEMWPSAKKKEKRRSKNPNSGNETSPAEGEPCDHHLDCLPGSCCDLREHLCKPHNRGLNNKCYDDCMCTEGLRCYAKFHRNRRVTRRKGRCVEPESANGDQGSFINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N567</accession>
    <name>A0A151N567_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0012171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004011">
        <property type="protein sequence ID" value="KYO31942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N567"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO31942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="69" mass="7964" checksum="3F8C91E72638D2A0" modified="2016-06-08" version="1">MVLRWMVLREHHILCVQSTAFSDLGHGCERATFLQFQLRRICSHLSSLMILLSSFTGLHCSWLYNQAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6J4</accession>
    <name>A0A151N6J4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Telomere length regulation protein TEL2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TELO2</name>
        <name evidence="12" type="ORF">Y1Q_0020399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6J4"/>
    <dbReference type="STRING" id="8496.A0A151N6J4"/>
    <dbReference type="eggNOG" id="KOG4346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000001">
        <property type="entry name" value="Telomere length regulation protein TEL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000003">
        <property type="entry name" value="Telomere length regulation protein TEL2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057348">
        <property type="entry name" value="TELO2_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25320">
        <property type="entry name" value="TELO2_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TELO2 ARM repeat" evidence="11">
        <location>
            <begin position="271"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="10">
        <location>
            <begin position="457"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KYO32452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="774" mass="86746" checksum="B60C2F83090C778A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8G8</accession>
    <name>A0A151N8G8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TTYH1</name>
        <name evidence="18" type="ORF">Y1Q_0011028</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Probable chloride channel.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:66338"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer; disulfide-linked. Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003823">
        <property type="protein sequence ID" value="KYO33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8G8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030868">
        <property type="term" value="C:smooth endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07912">
        <property type="entry name" value="Tweety_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF5">
        <property type="entry name" value="PROTEIN TWEETY HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 17" id="KW-0868">Chloride</keyword>
    <keyword evidence="10 17" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="464" mass="51509" checksum="340A6407CA876426" modified="2016-06-08" version="1">MGTPQGYQASWWVYLLHQAPRTNFQFEVVRNDFAPQDWSYQQALLFLASTAGLCLAISLVLICIYLIRFCCCDPEEDEPKAQRVCWVTWSCVAAVIVCCAGIGIGFYGNSEANDGANQATYALLNANHTLRAIDMLVWQTVGLLSAAVRGDLTRLEEMLAPRTELLAVVRNTRRQAEAVAHTLGGLPFWGDAGSNPSQLAEYLAFLEEYRWLAYILLLLLDLGICLFTLLGLAKQIKWLVIVMTAMSFLVLLLSWGSMGLETAAAVGLSDFCSDPDGYVINSTQAHTELNPEILQYYLICSQDVPNPFQQRLTLSQRALSNIHSQLYGLEREAVPQFPGAEKTLLSLRGTLNTTESNFHHLVALLNCRGLYKDYHWPSPQLSAACPGPGHASRAGTRTTMTWRMTTPSAPRSQSALFSGSRRYENMPLIDRCSPPPSYSPSMRASYAGAAHEEPDIQYRTEFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N8Z6</accession>
    <name>A0A151N8Z6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Synaptotagmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SYT2</name>
        <name evidence="17" type="ORF">Y1Q_0015007</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Chromaffin granule membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">Secretory vesicle</location>
            <location evidence="1 14">Synaptic vesicle membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N8Z6"/>
    <dbReference type="STRING" id="8496.A0A151N8Z6"/>
    <dbReference type="eggNOG" id="KOG1028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042584">
        <property type="term" value="C:chromaffin granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21964">
        <property type="entry name" value="Syt2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000007">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000016">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF223">
        <property type="entry name" value="SYNAPTOTAGMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 14" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="118"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="249"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO33241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="398" mass="45067" checksum="21AFBB3A12255660" modified="2016-06-08" version="1">MDNATHATSHEKDKDLFTKLSDFAKERFKEGIQKIPLPPWALIAIAVVVGLLFLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKSGNQNKQDDEEETGLTEGEGEEEEKEPENLGKLQFSLDYDFQANQLTVGILQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVQKKTLNPAFNETFTFKVPYQELGGKTLVMSIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQSGEKEEPEKLGDICISLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLLQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVTVVITVLDYDKLGKNEAIGKIFVGNNSTGTELRHWSDMLANPRRPIAQWHSLKPEEEVDAALGKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N963</accession>
    <name>A0A151N963_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003787">
        <property type="protein sequence ID" value="KYO33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N963"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="125" mass="14106" checksum="1D347F6167C2815B" modified="2016-06-08" version="1">MWLCHQAAVEPWLDQIRLRSNFQSLANLAAAVAAAIQRDLILSERINLASSRLQRIQKQLFLLNRNKQTPATSVTGYSNCTRGKNNRPFDLDLRTKCKSIMLKGSHWTKQKMAPGSTLCSVLCMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9W9</accession>
    <name>A0A151N9W9_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">POFUT2</name>
        <name evidence="21" type="ORF">Y1Q_0008740</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9W9"/>
    <dbReference type="STRING" id="8496.A0A151N9W9"/>
    <dbReference type="eggNOG" id="ENOG502QPS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11298">
        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11340:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO33571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="413" mass="47977" checksum="9BF07B7B93C7D4B6" modified="2016-06-08" version="1">MSSIRGPTTDLPKQKGSFPKPGHGAASLPGAAPAARRRYLLYDVNPPEGFNLRRDVYIRIASLLKTLLKREAWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLDKNIPVIEYEQFLAESGGPFIEQVYVLQGYAEGWKEGTWEEKIDERPCIDQLMYSKDKHDYYRGWFWGYEETRGLNVSCLSVQGSASIIAPTLLKNTSARSVMLDRAENLLHDHYGGRDYWNTRRSMVFAKHLRVVGDEFRNKYLDSTDEADKTHYNEDWAQMKVQLGTALGGSYLGVHLRRKDFIWGHREDVPTLHGAVKKIHSLMEIYKLKKVFVATDAIEEESEELKKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARYFIGTSVSTFSFRIHEEREILRFDPKTTYNRQIQRTISDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9Y2</accession>
    <name>A0A151N9Y2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0008774</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9Y2"/>
    <dbReference type="STRING" id="8496.A0A151N9Y2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO33620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="748" mass="83294" checksum="5812E2281D4523C2" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NA66</accession>
    <name>A0A151NA66_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Collagen alpha-1(III) chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0008849</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NA66"/>
    <dbReference type="KEGG" id="amj:102573460"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000001">
        <property type="entry name" value="Collagen alpha-1 type I chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000013">
        <property type="entry name" value="Collagen, type I, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585872" description="Collagen alpha-1(III) chain" evidence="13">
        <location>
            <begin position="23"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="14">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="15">
        <location>
            <begin position="1222"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
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            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
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            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="341"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
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        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
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        <location>
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            <end position="818"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
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        <location>
            <begin position="867"/>
            <end position="876"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="12">
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            <end position="942"/>
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        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
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        <location>
            <begin position="1042"/>
            <end position="1054"/>
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        <location>
            <begin position="1055"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1090"/>
        </location>
    </feature>
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        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1126"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1148"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1177"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO33723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1456" mass="140220" checksum="980B27EB3EA8E5A3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAA4</accession>
    <name>A0A151NAA4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein FAM57A isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FAM57A</name>
        <name evidence="8" type="ORF">Y1Q_0015301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003672">
        <property type="protein sequence ID" value="KYO33762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="amj:102558595"/>
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    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NAA4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF20">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="33"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO33762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="261" mass="29681" checksum="B4AD7F6A058C9ED2" modified="2016-06-08" version="1">MWQTLPVASVLFPGLFALCIRSLGWAAPAWSLKDRILLSGRLVSSVQAVMAAASGIIVVLNCKDVIHDRHWLAVEYVWVIVPYMTYDIYVMYLCHWHRSKDMGTTEKKNSLASVRSFLKKERLMVTHHLFILIVLTPITQHFRGELGDFFVGCIFLAELSTPFVSLGKTLMQLNMQDTRLHKVNGVLILVTFLLCRILLFPFMYGAYARQVGIPLYAAPFHIPVHCNVANACLIAPQLYWFVLICRKALRLYSCSSSDKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAE4</accession>
    <name>A0A151NAE4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Double C2-like domain-containing protein beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DOC2B-1</name>
        <name evidence="4" type="ORF">Y1Q_0015296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003672">
        <property type="protein sequence ID" value="KYO33756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAE4"/>
    <dbReference type="STRING" id="8496.A0A151NAE4"/>
    <dbReference type="eggNOG" id="KOG1013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017158">
        <property type="term" value="P:regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061669">
        <property type="term" value="P:spontaneous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000023">
        <property type="entry name" value="Double C2-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
        <property type="entry name" value="Rabphilin/DOC2/Noc2"/>
    </dbReference>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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            <taxon>Archosauria</taxon>
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    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
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    </reference>
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        <citation type="journal article" date="2016" name="Gen. Comp. Endocrinol." volume="238" first="13" last="22">
            <title>Molecular cloning and characterization of the aryl hydrocarbon receptors and aryl hydrocarbon receptor nuclear translocators in the American alligator.</title>
            <authorList>
                <person name="Oka K."/>
                <person name="Kohno S."/>
                <person name="Ohta Y."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Iguchi T."/>
                <person name="Katsu Y."/>
            </authorList>
            <dbReference type="PubMed" id="27174749"/>
            <dbReference type="DOI" id="10.1016/j.ygcen.2016.05.002"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Alligator mississippiensis genome assembly.</title>
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                <person name="Rice E.S."/>
                <person name="O'Connell B.L."/>
                <person name="Putnam N."/>
                <person name="Sugnet C."/>
                <person name="Stites J."/>
                <person name="Kern C."/>
                <person name="Gresham C."/>
                <person name="Mccarthy F."/>
                <person name="Schmidt C.J."/>
                <person name="Green R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="Proteomes" id="UP000050525">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="16">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1104" mass="122826" checksum="932FC686A0026E79" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NB60</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NB60"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="107" mass="12764" checksum="F9C90B24D7C0814C" modified="2016-06-08" version="1">MREATWQVKAQLSAWYREEARKKIFQARVPWMAEREEWSAYFSRLKKSKEEVMMCLRDGVGVEHQVKDSMLTAVAAFYQELYTEKLVDLEAVQLCLRSLIRTLREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NBY0</accession>
    <name>A0A151NBY0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003560">
        <property type="protein sequence ID" value="KYO34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NBY0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="99" mass="10898" checksum="206A9B4508A7B5CA" modified="2016-06-08" version="1">MYSENIISKLLSDTLPPAACTSSSKEKKMELAGFDLLHLKRRLIGLACGKYPVKPRFETLSDDAAPPIPDDMRVDTAAGHQTTIEQVSSYSWMVDGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDX5</accession>
    <name>A0A151NDX5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Beta-1,4-galactosyltransferase</fullName>
            <shortName evidence="17">Beta-1,4-GalTase</shortName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">B4GALT1</name>
        <name evidence="20" type="ORF">Y1Q_0000934</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1-&gt;4)-N-acetyl-D-glucosamine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17745"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60152"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="2.4.1.90"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:17746"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDX5"/>
    <dbReference type="STRING" id="8496.A0A151NDX5"/>
    <dbReference type="eggNOG" id="KOG3916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003831">
        <property type="term" value="F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003945">
        <property type="term" value="F:N-acetyllactosamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000028">
        <property type="entry name" value="beta-1,4-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF5">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14 17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="19">
        <location>
            <begin position="37"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="18">
        <location>
            <begin position="174"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO35021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="306" mass="35703" checksum="6A0EDC8DEB109B1E" modified="2016-06-08" version="1">MYKKLFPFTLVYMLGPLHIKNKPEPPRPDSAQPLRDCPATSPLLVGVLRIEFSQAVDLKEVEKTNPEVREGGRYAPKDCKALQRVAIIIPFRNREEHLKYWLYFLHPILQRQQLDYGVYVIHQDGDEEFNRAKLLNIGFKEALKTYDYDCFVFSDVDLIPMDDRNIYKCYSQPRHLSVSMDKFGFRLPYNQYFGGVSALSKEQFLKINGFPNNYWGWGGEDDDIYNRLVFKGMGISRPDAIIGKCRMIRHSRDQKNEPNPERFDRIAHTRETMNSDGINSLSYKVLRTDKYPLYTKILVDIGSPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG11</accession>
    <name>A0A151NG11_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epidermal differentiation-specific protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0020728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003150">
        <property type="protein sequence ID" value="KYO35589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG11"/>
    <dbReference type="eggNOG" id="ENOG502R7EM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20230">
        <property type="entry name" value="PFM_EP37-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF103">
        <property type="entry name" value="BETA_GAMMA CRYSTALLIN 'GREEK KEY' DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="4">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="4">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO35589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="366" mass="40984" checksum="33E71257D51ECD6F" modified="2016-06-08" version="1">MEVAPAEPSANRIVVYERPGFEGLQREFTCDVPDLHELDFGDCISSLRVVGQPWVAYTGPKYEGDAFPFEEGEYAEVEPRGSFSSLRLVHHDLDEPQITLYEDAGFAGRSKVVTEETNLAYGYFDDRVSSHEVQRGVWLLYQDPGRGGQRYIAWPGERLADYRPGLRLQDRLSHLRPLRPGRPRITARLLWDQKRVEEEREVLLDEMVAVNETETEQALSSGSSREYSTVTAQSFHFSAATRLRAGLAFTLALEAAAEFRVEKGRSESRTLRERAEVLLPAKVPPRTRLAVQVVRREAAVVVPVELTLLQNERVRTERGEYRCRSAASLCARYTMTPIADPAPDRRGPAAPAPAPDDAPAPAPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NG99</accession>
    <name>A0A151NG99_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Fatty-acid amide hydrolase 1</fullName>
            <ecNumber evidence="3">3.5.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="37">Anandamide amidohydrolase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="35">Fatty acid ester hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="36">Oleamide hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="41" type="primary">FAAH-1</name>
        <name evidence="41" type="ORF">Y1Q_0003585</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="41 42" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="41">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63120"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32426"/>
            <dbReference type="ChEBI" id="CHEBI:146167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63121"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63004"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:77220"/>
            <dbReference type="ChEBI" id="CHEBI:146165"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:63005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)-eicosatrienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63000"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:77223"/>
            <dbReference type="ChEBI" id="CHEBI:146164"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:63001"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63028"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32392"/>
            <dbReference type="ChEBI" id="CHEBI:146166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:63029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:137830"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:63017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63008"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32375"/>
            <dbReference type="ChEBI" id="CHEBI:146168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:63009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:62996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:71589"/>
            <dbReference type="ChEBI" id="CHEBI:146163"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:62997"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:26506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:116314"/>
            <dbReference type="EC" id="3.5.1.99"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:26507"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:133992"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:51318"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:63020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:82984"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:63021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)-octadecatrienoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:62976"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32387"/>
            <dbReference type="ChEBI" id="CHEBI:142684"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:62977"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = methanol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63052"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:78033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:63053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:26133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(15Z-tetracosenoyl)-ethanolamine + H2O = (15Z)-tetracosenoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:63144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32392"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:146187"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>N-(15Z-tetracosenoyl)-taurine + H2O = (15Z)-tetracosenoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:63160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32392"/>
            <dbReference type="ChEBI" id="CHEBI:146198"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:63161"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:64108"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:59002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:64109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:64116"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:149697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:64117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = ethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate</text>
            <dbReference type="Rhea" id="RHEA:26136"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="3.5.1.99"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:26137"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-(9Z-hexadecenoyl) ethanolamine + H2O = (9Z)-hexadecenoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:35563"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:71465"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:35564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-(9Z-octadecenoyl) ethanolamine + H2O = ethanolamine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:45060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:45061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N-(9Z-octadecenoyl)-taurine + H2O = taurine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:63148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:146191"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:63149"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N-docosanoyl-ethanolamine + H2O = docosanoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:63128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:23858"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:146186"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:63129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N-docosanoyl-taurine + H2O = docosanoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:63156"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:23858"/>
            <dbReference type="ChEBI" id="CHEBI:146196"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:63157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N-octadecanoyl ethanolamine + H2O = octadecanoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:63124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:85299"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:63125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-tetracosanoyl-taurine + H2O = tetracosanoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:63140"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:132049"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:63141"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N-tricosanoyl-taurine + H2O = tricosanoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:63164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:79007"/>
            <dbReference type="ChEBI" id="CHEBI:146197"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:63165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tetradecamide + H2O = tetradecanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:62992"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:137125"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:62993"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="41">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.99" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03003081">
        <property type="protein sequence ID" value="KYO35856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NG99"/>
    <dbReference type="STRING" id="8496.A0A151NG99"/>
    <dbReference type="GeneID" id="102568858"/>
    <dbReference type="KEGG" id="amj:102568858"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000001">
        <property type="entry name" value="Fatty-acid amide hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF8">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 41" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="40">
        <location>
            <begin position="102"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="38">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="38">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="38">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="39">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00052634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00052709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00052818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00052857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00052906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00073178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00077111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00077157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00077216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="EMBL" id="KYO35856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="590" mass="64909" checksum="B8D8604B148D0B18" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NH53</accession>
    <name>A0A151NH53_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein MGARP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MGARP</name>
        <name evidence="2" type="ORF">Y1Q_0020640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003015">
        <property type="protein sequence ID" value="KYO36142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NH53"/>
    <dbReference type="STRING" id="8496.A0A151NH53"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="141" mass="15234" checksum="CC203D216A09ECE4" modified="2016-06-08" version="1">MPSLSYYIHPLKGNEEDSAEVTESKEETLAVAAEEVEAAPADGPTEQKEVAMETEGEKELPGADASLAVEAAQQEAAATLEAAPMQETAGDVLDAAASPASAHEEKKLLLRDLGKLQKFLLKERHLKMFLRILKGSNREDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMT0</accession>
    <name>A0A151NMT0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-binding protein 41</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RNA-binding motif protein 41</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RBM41-1</name>
        <name evidence="8" type="ORF">Y1Q_0007246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May bind RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMT0"/>
    <dbReference type="STRING" id="8496.A0A151NMT0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12239">
        <property type="entry name" value="RRM2_RBM40_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000252">
        <property type="entry name" value="RNA binding motif protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="306"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00067964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO38127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="447" mass="49739" checksum="64ED23779B9BC085" modified="2016-06-08" version="1">MRRVNSCLSADDVLLEDLETEGERQLKSLLHHQLDTTVSIEQCKSKRRCFAPAAFYKPFGEEAAGALTLSQFQALQENDKETASLRELGLSDSEILLWKNQTSAQKGSGLGAAPEATQHRLQAIQEKITERQHILSLPQRFAGSKQLSRREMEIENALFQGTDRHSFLRALYHQDEAQKRLASEKDPMGNLETVYQEMLSKQLPEECPCVEGDPCWPCSLALTGPVNKETRLLSNQEKKVEHDGDPIVPAPKPVESEAQQPTPNPVAIKESVDFIPEEEIQKNRLSEEEIQNIPRFASYSPGKPSKVLYLKNLSPRVTVRELVSLFARFQEKDRPPIQFRLLNGRMRGQAFITFSSVEVAQKALLLVNGYNLQGKPLVIEFGKNKGQSSSDSASPSCGAVNSVDYKQATLALFGEDAYIPPHSAVPGESQLKSSCLVIEGTNTLLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMU8</accession>
    <name>A0A151NMU8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="33">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="33">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="39" type="ORF">Y1Q_0007265</name>
    </gene>
    <organism evidence="39 40">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="39 40" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="39">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28 33">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="33">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="39">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="33"/>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMU8"/>
    <dbReference type="STRING" id="8496.A0A151NMU8"/>
    <dbReference type="eggNOG" id="KOG0197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01238">
        <property type="entry name" value="PH_Btk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05113">
        <property type="entry name" value="PTKc_Btk_Bmx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10397">
        <property type="entry name" value="SH2_Tec_Btk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11906">
        <property type="entry name" value="SH3_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000191">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000125">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000040">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035574">
        <property type="entry name" value="BTK_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00402">
        <property type="entry name" value="TECBTKDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00107">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0007">Acetylation</keyword>
    <keyword evidence="23" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="17 32 33" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="15 33" id="KW-0418">Kinase</keyword>
    <keyword evidence="22" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="24" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 32 33" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="40" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20 29" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="6 30" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="26" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11 33" id="KW-0808">Transferase</keyword>
    <keyword evidence="25 33" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="14 31" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="37">
        <location>
            <begin position="54"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="36">
        <location>
            <begin position="263"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="35">
        <location>
            <begin position="330"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="38">
        <location>
            <begin position="452"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="32">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="EMBL" id="KYO38151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="709" mass="82113" checksum="FA13EB5A16E229AB" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NMZ5</accession>
    <name>A0A151NMZ5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0015488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NMZ5"/>
    <dbReference type="STRING" id="8496.A0A151NMZ5"/>
    <dbReference type="eggNOG" id="KOG0587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06636">
        <property type="entry name" value="STKc_MAP4K4_6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000003">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000006">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
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                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
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                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
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                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
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                <person name="McCormack J.E."/>
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                <person name="Pourmand N."/>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="211"/>
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        <location>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
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                <person name="Braun E.L."/>
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                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
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                <person name="Lance S.L."/>
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                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="271" mass="30686" checksum="8C32008D961EF826" modified="2016-06-08" version="1">MELDSSYSSCISDYSDDTFESFSEEEEACKQYENEPFASYCTTENSECPAVSDVSESTWKSTSQNDEGELLDSATIEKDLMGKWINCLKNKAAGTGESKPVMRTRTEIPEVPAEELDALQNFCTIKISQIHHQLICEQSNSCKHKELQHGFTSEKSVTGALNCIVPDQLVNRIHLKNIRETVKQVTETKVHQTSQCPDCQKKKAELAKVTFLRQRKTLMEGCLLQEKLEEQIYTKDLLTLIGLIHKSLPKLSDDPKNIWQKLKVKGLETSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNM0</accession>
    <name>A0A151NNM0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNM0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7741" checksum="CA321DE9732B0022" modified="2016-06-08" version="1">MRRLPGSVKDWGILSSAISSEWNEPAQSYALMWFDSASYQDSSVPSPRRGISCWHLDLWYWQGLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NPU0</accession>
    <name>A0A151NPU0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC146</name>
        <name evidence="3" type="ORF">Y1Q_0023381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NPU0"/>
    <dbReference type="STRING" id="8496.A0A151NPU0"/>
    <dbReference type="eggNOG" id="ENOG502QPM4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF34">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="334"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="565"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO38669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="856" mass="100392" checksum="AFD06FA38736419A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NR89</accession>
    <name>A0A151NR89_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CFAP52</name>
        <name evidence="2" type="ORF">Y1Q_0020493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002324">
        <property type="protein sequence ID" value="KYO39294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NR89"/>
    <dbReference type="STRING" id="8496.A0A151NR89"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO39294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="97" mass="10475" checksum="ECB514D5DD316520" modified="2016-06-08" version="1">MGEKQGGVTALLLLKTGDLVVGTGGGIIALFKGSNYKSIKKIQVQGGVTSLTRRGQGHQFFAGTEESQIYRINFAEFKEECIATCHNEAINDIIFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NSX0</accession>
    <name>A0A151NSX0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">p-selectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0006729</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the selectin/LECAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002184">
        <property type="protein sequence ID" value="KYO39864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NSX0"/>
    <dbReference type="STRING" id="8496.A0A151NSX0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of protein kinase C signaling"/>
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        <property type="term" value="P:synapse maturation"/>
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    </dbReference>
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        <property type="entry name" value="Complement Module, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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        <property type="entry name" value="C-type_lectin-like"/>
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        <property type="entry name" value="C-type_lectin_CS"/>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="Selectin_CTLD"/>
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        <property type="entry name" value="Selectin_superfamily"/>
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    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
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        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
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        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
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        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
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    </dbReference>
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        <property type="entry name" value="SEIZURE 6-LIKE PROTEIN 2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C-type lectin-like"/>
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    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
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    </dbReference>
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        <property type="entry name" value="C_TYPE_LECTIN_1"/>
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    </dbReference>
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        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SUSHI"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0768">Sushi</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586355" evidence="20">
        <location>
            <begin position="35"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="23">
        <location>
            <begin position="199"/>
            <end position="259"/>
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    </feature>
    <feature type="domain" description="Sushi" evidence="23">
        <location>
            <begin position="273"/>
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    </feature>
    <feature type="domain" description="Sushi" evidence="23">
        <location>
            <begin position="324"/>
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    </feature>
    <feature type="domain" description="Sushi" evidence="23">
        <location>
            <begin position="386"/>
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    </feature>
    <feature type="domain" description="Sushi" evidence="23">
        <location>
            <begin position="448"/>
            <end position="509"/>
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    </feature>
    <feature type="domain" description="Sushi" evidence="23">
        <location>
            <begin position="510"/>
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    </feature>
    <feature type="domain" description="Sushi" evidence="23">
        <location>
            <begin position="572"/>
            <end position="633"/>
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    </feature>
    <feature type="domain" description="Sushi" evidence="23">
        <location>
            <begin position="634"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="186"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="356"/>
            <end position="383"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="418"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="542"/>
            <end position="569"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="604"/>
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    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="666"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO39864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="763" mass="84282" checksum="6BC97D40A15EE36C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUA3</accession>
    <name>A0A151NUA3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dedicator of cytokinesis protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0009001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001975">
        <property type="protein sequence ID" value="KYO40323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NUA3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08696">
        <property type="entry name" value="C2_Dock-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037808">
        <property type="entry name" value="C2_Dock-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF65">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="545"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="6">
        <location>
            <begin position="1460"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1199"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO40323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1951" mass="218668" checksum="7B6E6F466FAB39E0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NUJ8</accession>
    <name>A0A151NUJ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent dioxygenase alkB-like protein 7, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0009006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001975">
        <property type="protein sequence ID" value="KYO40330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NUJ8"/>
    <dbReference type="STRING" id="8496.A0A151NUJ8"/>
    <dbReference type="eggNOG" id="KOG4176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF5">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="3">
        <location>
            <begin position="575"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO40330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="713" mass="79609" checksum="B37BE759B7254770" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NV11</accession>
    <name>A0A151NV11_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0012245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001868">
        <property type="protein sequence ID" value="KYO40752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NV11"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO40752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="134" mass="13987" checksum="3620E56C2DA96C0D" modified="2016-06-08" version="1">MTADQLLQPTRQEGTADTLPSVAPPTADTERTSGAADSQPPPGSSGPTQRLVWVRASLQLHPPCCQEESKDVGTGDVPAAAPHITEAQTGAAKDECAGSESYPQETKPESDPKYVCLGKELIKKACMACRGPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWI2</accession>
    <name>A0A151NWI2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001669">
        <property type="protein sequence ID" value="KYO41124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWI2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO41124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="73" mass="8920" checksum="DEF4ACF8F1485EDA" modified="2016-06-08" version="1">MHQVHQKTQDQILLLDWLEMASEEQLVDEWAWRAKNITQQYRWQAEDLAHEEVWDWVDCVFTAWILAGEEQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NWW3</accession>
    <name>A0A151NWW3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Y1Q_0006218</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NWW3"/>
    <dbReference type="STRING" id="8496.A0A151NWW3"/>
    <dbReference type="eggNOG" id="KOG1966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001953">
        <property type="entry name" value="NHE-2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032103">
        <property type="entry name" value="NHE_CaM-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF89">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16644">
        <property type="entry name" value="NEXCaM_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01086">
        <property type="entry name" value="NAHEXCHNGR2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="15">
        <location>
            <begin position="17"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/hydrogen exchanger regulatory region" evidence="16">
        <location>
            <begin position="504"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="620"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO41392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="743" mass="84713" checksum="405587F2A9A8955C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NX69</accession>
    <name>A0A151NX69_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0018059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001767">
        <property type="protein sequence ID" value="KYO41005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NX69"/>
    <dbReference type="STRING" id="8496.A0A151NX69"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO41005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="141" mass="16021" checksum="A8ABBBEEA11A89C6" modified="2016-06-08" version="1">MPGSPGAELSPQQRMPSPWQTLWLEELSRATAFEAFEASVARLTEELSAGARPDQPRGNSRPATRQDHRPQPQRRPRRQRYDQVAASRIKKLYRAKSPKAVREILEGPSAFCLVPREALFRYFGRVFNPQAEAAAPRPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXW1</accession>
    <name>A0A151NXW1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Guanine nucleotide exchange factor for Rab-3A isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RAB3IL1-1</name>
        <name evidence="10" type="ORF">Y1Q_0006385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXW1"/>
    <dbReference type="STRING" id="8496.A0A151NXW1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4880:FF:000001">
        <property type="entry name" value="Guanine nucleotide exchange factor for Rab-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF5">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="9">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="122"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO41638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="435" mass="48575" checksum="0B320C034B25046B" modified="2016-06-08" version="1">MDAGTTVYNLSAFDYPSGAKAREGTAETWNAGVLMCECPVEASQDGEGPSAVGSQAQFEEGGQKQQVVGQWKPLVPSKGGKELLESKPCCLDAGGGDETQSTAQLNVSRLRSSSVEIREKGSEFLKEELHKAQKELKLKDEECERLSKVREQLEQELEELTASLFEEAHKMVREANTKQAASEKQMREARGKIDMLQAEVTALKTLVITSTPSSPNRELHPQLQSPTKAVFRKGHGRNKSTSSAVSTASGQSLPLEPVNHEYKEVDAILFAEFQAWKEAPTLDKACSFLERIYREDVEPCLDFTRHELSELVRAAVEQNTLTIEPVASQVLPVVKVSTIECGRPNGFRSQIVTKCALSGLSRTCKHRIKLGDSGNYYYISPSCRARITAVCNFFTYIRYIQQGLVRQDVELMYWEIMRLRREMSMAKLGFYPNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NXZ1</accession>
    <name>A0A151NXZ1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pepsin A</fullName>
            <ecNumber evidence="3">3.4.23.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PGA3</name>
        <name evidence="14" type="ORF">Y1Q_0006413</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.1" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03001628">
        <property type="protein sequence ID" value="KYO41668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NXZ1"/>
    <dbReference type="SMR" id="A0A151NXZ1"/>
    <dbReference type="STRING" id="8496.A0A151NXZ1"/>
    <dbReference type="GeneID" id="102562866"/>
    <dbReference type="KEGG" id="amj:102562866"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="PhylomeDB" id="A0A151NXZ1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000006">
        <property type="entry name" value="Cathepsin E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000004">
        <property type="entry name" value="Pepsin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF22">
        <property type="entry name" value="PEPSIN A-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0222">Digestion</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013085353" description="pepsin A" evidence="12">
        <location>
            <begin position="16"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="74"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="105"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KYO41668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="386" mass="41900" checksum="1FE68BC513F1035C" modified="2016-06-08" version="1">MKWLVLLSLVALSQCLVTKVPLKKRKPLRMTLKEQGLLLDFLKNHHYNLGSKYIPGIINEDATEPMKNSLDLQYFGTISIGTPAQEFTVLFDTGSSNLWVPSVYCSSPACKNHHSFNPKKSSTYQATNESISIQYGTGSMTGFLAYDIIHVGGIPVTHQIFGLSESEPGPFLSYAAFDGILGLAFPSISASAATPVFDNMMSQDLVSQDLFSVFLSSDEKNGSFVMFGGIDSSYYSGSLKWIPLSAETYWQITVDRISMNGQAIACGNGCQAIIDTGTSLLAGPPDAVSSIQSLIGAKEDLYGEYTMNCNASNILPDIVFTINGIDFPLPASAYVFNMSGSCQSGFQSIDITTAKGELWILGDIFIRQYYTVFDRGNNKVGLAPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NYV3</accession>
    <name>A0A151NYV3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YTH domain-containing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">YTHDF3</name>
        <name evidence="8" type="ORF">Y1Q_0002624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the YTHDF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001485">
        <property type="protein sequence ID" value="KYO41964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NYV3"/>
    <dbReference type="STRING" id="8496.A0A151NYV3"/>
    <dbReference type="eggNOG" id="KOG1901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000001">
        <property type="entry name" value="YTH domain family 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF65">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="7">
        <location>
            <begin position="403"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO41964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="573" mass="62675" checksum="273B0784D983D515" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P039</accession>
    <name>A0A151P039_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Y1Q_0011428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001425">
        <property type="protein sequence ID" value="KYO42501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P039"/>
    <dbReference type="STRING" id="8496.A0A151P039"/>
    <dbReference type="eggNOG" id="KOG3900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19384">
        <property type="entry name" value="TGF_beta_TGFB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000004">
        <property type="entry name" value="Transforming growth factor beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016319">
        <property type="entry name" value="TGF-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF125">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01423">
        <property type="entry name" value="TGFBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-0497">Mitogen</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="12">
        <location>
            <begin position="126"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KYO42501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="242" mass="27608" checksum="12CCF6739CD2A545" modified="2016-06-08" version="1">MLRKPYTAQAPAAQRVELYQKFGAGSWRYVETREVALGPEPQWLAFDVTDALRFWLAGHEPWGFFKLSPHCSCEDDHSTAEILFQIDGFETFRGDMGKVKMQGQRLPFLLATATPPERAAQLQSPRHRRAAADTAYCFGTEEKNCCVRKLYIDFRQDLKWKWIHEPRGYWAHLCTGACPYIWSSDTQYSKVLALYNQHNPGASAAPCCAPETLDPLTIVYYVGRKAKVEKLSNMIVRSCKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P130</accession>
    <name>A0A151P130_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein lin-54 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LIN54</name>
        <name evidence="15" type="ORF">Y1Q_0022384</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001358">
        <property type="protein sequence ID" value="KYO42723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P130"/>
    <dbReference type="STRING" id="8496.A0A151P130"/>
    <dbReference type="eggNOG" id="KOG1171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF36">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CRC" evidence="14">
        <location>
            <begin position="602"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO42723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="828" mass="87827" checksum="62E5B0E076E0169B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P1E8</accession>
    <name>A0A151P1E8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TIMM10B</name>
        <name evidence="10" type="ORF">Y1Q_0000218</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001327">
        <property type="protein sequence ID" value="KYO42916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014453484.1">
        <property type="nucleotide sequence ID" value="XM_014597998.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P1E8"/>
    <dbReference type="STRING" id="8496.A0A151P1E8"/>
    <dbReference type="GeneID" id="106737642"/>
    <dbReference type="KEGG" id="amj:106737642"/>
    <dbReference type="CTD" id="26515"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO42916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="11592" checksum="DABA61A8AA51CBAD" modified="2016-06-08" version="1">MEPSAEQQQLRSLRDFLLLYNRMTELCFARCVADMDCRPLTHPEDSCVERCAVKLVRANHSLMRAYVRLMPALVQRRAADLEAAAGIDTGTGTDTNVLQRAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2P8</accession>
    <name>A0A151P2P8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Yae1 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">YAE1D1</name>
        <name evidence="1" type="ORF">Y1Q_0017514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001210">
        <property type="protein sequence ID" value="KYO43189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P2P8"/>
    <dbReference type="STRING" id="8496.A0A151P2P8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO43189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="212" mass="24037" checksum="07A65053AA512391" modified="2016-06-08" version="1">METYKRMSNLSFQKLYKSNCFTHHSRCTISGNREHFVQRSWRRGAPATMSWVQAAVSRPREDVFDEDADEMHLVQKEWKSTMEKRIKVLDTGTPPAVLVALLSWCHLNRHDSALLSKINDLLDAVGKYEEHVLKCLNSVHPQPHLGELLDSVQDMDLSCTIPAEEEFNGTKSERPCGSGATFSESCCRSNACGESGEEIRTLSSPEAHQNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P2Y6</accession>
    <name>A0A151P2Y6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0013497</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151P2Y6"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000543">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000009">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000004">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000002">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.10.490.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
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        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
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    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="714"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="995"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1321"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1930"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2166"/>
            <end position="2214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO43432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="3362" mass="384636" checksum="4A23F3044E5AA4BA" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P3K9</accession>
    <name>A0A151P3K9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Denticleless protein-like protein isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DTL</name>
        <name evidence="18" type="ORF">Y1Q_0013644</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001146">
        <property type="protein sequence ID" value="KYO43636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019338746.1">
        <property type="nucleotide sequence ID" value="XM_019483201.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P3K9"/>
    <dbReference type="STRING" id="8496.A0A151P3K9"/>
    <dbReference type="GeneID" id="102559463"/>
    <dbReference type="CTD" id="51514"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051247">
        <property type="term" value="P:positive regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000447">
        <property type="entry name" value="Denticleless protein homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000171">
        <property type="entry name" value="denticleless protein homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="678"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO43636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="745" mass="82039" checksum="DA1347DF6C0434CD" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P4H6</accession>
    <name>A0A151P4H6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stathmin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">STMN4-1</name>
        <name evidence="6" type="ORF">Y1Q_0005865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stathmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03001036">
        <property type="protein sequence ID" value="KYO43964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P4H6"/>
    <dbReference type="STRING" id="8496.A0A151P4H6"/>
    <dbReference type="eggNOG" id="KOG1280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030514">
        <property type="entry name" value="Stathmin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF6">
        <property type="entry name" value="STATHMIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00563">
        <property type="entry name" value="STATHMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01041">
        <property type="entry name" value="STATHMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO43964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="260" mass="29598" checksum="1AEFBA354CB45685" modified="2016-06-08" version="1">MTLAAYKEKMKELPLVSLFCSCFLSDPLNKPAYKYEADTVDLTWCVISDMEVIELNKRTSGQSFEVILKPPSFDGIPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELKEEASRHGAAGKSSAFRAREAGGCDGDGKDAEESMGFTITHQLGQGFPRHQLTCTPVSGPGHDHLRLLEKLVALEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P5E8</accession>
    <name>A0A151P5E8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA-splicing factor CWC25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CWC25</name>
        <name evidence="11" type="ORF">Y1Q_0012065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000817">
        <property type="protein sequence ID" value="KYO44286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P5E8"/>
    <dbReference type="STRING" id="8496.A0A151P5E8"/>
    <dbReference type="eggNOG" id="KOG3869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028027">
        <property type="entry name" value="SPMAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15075">
        <property type="entry name" value="SPMAP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="10">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO44286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="571" mass="66682" checksum="716F4F4FC536F63C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P8I0</accession>
    <name>A0A151P8I0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrous sheath-interacting protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0007345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000635">
        <property type="protein sequence ID" value="KYO45035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P8I0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038891">
        <property type="entry name" value="FSIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031554">
        <property type="entry name" value="FSIP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21856">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21856:SF7">
        <property type="entry name" value="FIBROUS SHEATH-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15783">
        <property type="entry name" value="FSIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrous sheath-interacting protein 2 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO45035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="177" mass="20303" checksum="9181D9CD92F1F27E" modified="2016-06-08" version="1">MEPFSRNSFQNVLEPDITRVELLKDVQTKEDLVVRLVVHDIENNKDEEQVVVNLKAEDWEYDEEDDDEMQQEEEEKEISEDIIKVESSHLMMSLLTSSMDNEQLSVEEFEEASSAFQAQHKSTCASLCHTRDTKASAHSSKVDGASPSSHIASSMIRCCFNCFRSNRQKTPLRKDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151P9X8</accession>
    <name>A0A151P9X8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Y1Q_0021483</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000533">
        <property type="protein sequence ID" value="KYO45848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151P9X8"/>
    <dbReference type="STRING" id="8496.A0A151P9X8"/>
    <dbReference type="eggNOG" id="KOG4403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="478"/>
            <end position="510"/>
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        <location>
            <begin position="542"/>
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        <location>
            <begin position="636"/>
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    </feature>
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        <location>
            <begin position="215"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="16">
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            <begin position="478"/>
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            <begin position="542"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KYO45848.1"/>
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    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
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    </evidence>
    <sequence length="696" mass="79469" checksum="6B782853909B57DE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PAJ5</accession>
    <name>A0A151PAJ5_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-sarcoglycan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SGCB</name>
        <name evidence="20" type="ORF">Y1Q_0021588</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <location evidence="3">Sarcolemma</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KYO45990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
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    <dbReference type="GO" id="GO:0042383">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
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        <property type="entry name" value="Sgcb"/>
    </dbReference>
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        <property type="entry name" value="BETA-SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SARCOGLYCANS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002860"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015329"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026041"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO45990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="509" mass="57421" checksum="227CA8C3301796B0" modified="2016-06-08" version="1">MAAAASEQQSSNGPVKKSMREKAVERRNINKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIVLLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGLLRFKQISDMGVIHPLYKSTVGGRRNEDLVITGNNQPIVFQQGTTKLSVEKDKTSITSDIGMEFVDPRTQNTLFSTDYETHEFHLPNGVKILNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKMIEFRMGGDMELKAENSIILNGTVMVSTSRLPSSSYGEQFNNGDWVRYKLCMCADDIMANSYLSVMALVLLLNYTGSSGFKSQETDSFRNLPFLETLNLNGNIIHYIVLDICKSEDWSEKHRKVYTYGLLPFLKVLAIERNNLSAIPRGLGMLQSLRSVHLSSNEILQIEQNDFHNCSQIKNIYLQNNKITKIHPDAFKNLKKLQVLDLSNNVMTTILPEMFIELNIFNLEERHLCYTVVWMKHGEKKKSIGGLLVAEFPKITGFLILNRMKLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PCL2</accession>
    <name>A0A151PCL2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000487">
        <property type="protein sequence ID" value="KYO46847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PCL2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO46847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="80" mass="9061" checksum="5FCB2EB98AABE581" modified="2016-06-08" version="1">MPTFMSTNLEPLAEADLGFTELSADEPVRVFCFFYPISDPQEEATISPICIQGHCVTMEMVDRYHSLFTDTPPHLKHEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDP2</accession>
    <name>A0A151PDP2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 2J6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Y1Q_0002200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000476">
        <property type="protein sequence ID" value="KYO47182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDP2"/>
    <dbReference type="STRING" id="8496.A0A151PDP2"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000176">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF134">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 2, SUBFAMILY AB, POLYPEPTIDE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO47182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="891" mass="102073" checksum="CFBD7ACA6EE965A4" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PDU9</accession>
    <name>A0A151PDU9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0019994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000474">
        <property type="protein sequence ID" value="KYO47287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PDU9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO47287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="360" mass="39125" checksum="178FE4FB7ED80B3B" modified="2016-06-08" version="1">MLKSFLLLWVDGFLLCASVILLHSLGVHLWRWLLAEREGKGAKKQEVKWAQSSRRLSVCQLVCDNPACHISTPTALAPMPALLPATSEQGQPSGPLPGAVLMRPCGRVAGSGGATALQELQLQPRVRAVLQSAMAKKGMEIHLETFPALARGSWRRLQHLSQLPLPKLIQAGDSALQPRSRHLPFVPSDSLDRVDLAVQRQRLGSLLGLLALHLESITPRAIQASSGPDVLGRSPIESLQTGAPFLRPYALEVHVGTKKQPCAWGWPELMEKSLGAFVLGSPRMMWTPARHRAELQVYVGGTGPPPISSETRSCPEHHISRGYSTSPSHHYTHLHVHIQGPGAPPISLETRSGLESRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PGT0</accession>
    <name>A0A151PGT0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">adenylate cyclase</fullName>
            <ecNumber evidence="20">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ADCY2</name>
        <name evidence="26" type="ORF">Y1Q_0010616</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19 20">Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="22">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="22">Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20 23">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="20"/>
    <dbReference type="EMBL" id="AKHW03000242">
        <property type="protein sequence ID" value="KYO48240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PGT0"/>
    <dbReference type="STRING" id="8496.A0A151PGT0"/>
    <dbReference type="eggNOG" id="KOG3619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000003">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000020">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030672">
        <property type="entry name" value="Adcy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF10">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039050">
        <property type="entry name" value="Ade_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 20" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 20 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 20 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0464">Manganese</keyword>
    <keyword evidence="16 20 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="25">
        <location>
            <begin position="173"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="25">
        <location>
            <begin position="755"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="887"/>
            <end position="889"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="894"/>
            <end position="898"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="934"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00053200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR039050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KYO48240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="959" mass="108432" checksum="D39BD0382F017055" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PH47</accession>
    <name>A0A151PH47_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0022630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000190">
        <property type="protein sequence ID" value="KYO48421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PH47"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11969" checksum="44CC7F8E99E03845" modified="2016-06-08" version="1">MEYIARQDRWWAEDVAHEKAQDEVEDWADWEFWVQLLALEHEWVKALQEQNTRLAQAVQVRDDDHWVLDTVLALVVTFVPPIAWLLTLALPLPWQPPTAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PHQ6</accession>
    <name>A0A151PHQ6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0004024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PHQ6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO48616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="11848" checksum="A60C8B5437696C93" modified="2016-06-08" version="1">MFSLTSIDDEAEEVEGQEETHAADASSTTTKTQEHAGPARMAAIDLFPNHHNPWLPGMASCSHFSRVLQRFSQQAEMVPQKLTRGFGRVLSSQSGTHRCLAGQAPRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PI28</accession>
    <name>A0A151PI28_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0004066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PI28"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO48668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="117" mass="13844" checksum="AF02D33B38E9AD9B" modified="2016-06-08" version="1">MHGGAMAWTTGSSTPDLCSWEDCRLSNSRDYISLSMNTWLFYKQWERENLLEKHELHSHKTEVTKWRRRSCELCLLVYLVSVNMSLTQSQMARLCMRRGHYACILHQLKGFTPYPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PI30</accession>
    <name>A0A151PI30_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0003987</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03000179">
        <property type="protein sequence ID" value="KYO48564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151PI30"/>
    <dbReference type="STRING" id="8496.A0A151PI30"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17440">
        <property type="entry name" value="MFS_SV2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000009">
        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000721">
        <property type="entry name" value="Synaptic vesicle glycoprotein 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055415">
        <property type="entry name" value="LD_SV2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022308">
        <property type="entry name" value="SV2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01299">
        <property type="entry name" value="synapt_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF6">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23894">
        <property type="entry name" value="LD_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="239"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="297"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="450"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="599"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="625"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="718"/>
        </location>
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            <begin position="25"/>
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        </location>
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            <begin position="109"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KYO48564.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="758" mass="86024" checksum="91B48ED4833E0CB1" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151PJ32</accession>
    <name>A0A151PJ32_ALLMI</name>
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        <submittedName>
            <fullName evidence="5">Protein S100-A7-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">Y1Q_0000798</name>
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        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transition metal ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="S-100"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
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        <property type="entry name" value="S-100_dom"/>
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        <property type="entry name" value="S100_Ca-bd_sub"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
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            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO48992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="221" mass="25936" checksum="1C46FB0620E98FC7" modified="2016-06-08" version="1">MEVSHAHMKPKTQLEKELQCIVDIYHQYSFRNPIDDYLQKGEFKKLLKEQAADFLRNTKPPKMTLEQYLELLFEKADKNHDGHIKFTEPRSPEHPAMSESPVTIPMPRPSPRPASECDPNCTLQTALELIVRIYHRYSSSVNRNDTLNQQELKLFLNREAPTFLEACDRDKPGYIKMLFRDTDMNQDRKLSFEEFTKILAMLTDDAHRISHRDDRCGPDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LYV5</accession>
    <name>A0A151LYV5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubinuclein-2 isoform B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UBN2</name>
        <name evidence="3" type="ORF">Y1Q_0020066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LYV5"/>
    <dbReference type="STRING" id="8496.A0A151LYV5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF10">
        <property type="entry name" value="UBINUCLEIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubinuclein middle" evidence="2">
        <location>
            <begin position="126"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO17457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="616" mass="66907" checksum="93D1F02E79736CA3" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151LZ75</accession>
    <name>A0A151LZ75_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 25 member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phosphate carrier protein, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phosphate transport protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SLC25A3-1</name>
        <name evidence="20" type="ORF">Y1Q_0020137</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment. Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP. Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly. May also play a role in regulation of the mitochondrial permeability transition pore (mPTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>phosphate(in) + H(+)(in) = phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:29941"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PPIF; the interaction is impaired by CsA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03007000">
        <property type="protein sequence ID" value="KYO17551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151LZ75"/>
    <dbReference type="STRING" id="8496.A0A151LZ75"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000046">
        <property type="entry name" value="Phosphate carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="60"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="195"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO17551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="296" mass="32903" checksum="208A2EE6F29E2DAA" modified="2016-06-08" version="1">MFSSLAPLARANPFYAPHLQLAQDGVRRRPEPAEPTSTPRRLAAASPAEEEYSCEYGSLKFYALCGFGGVLSCGLTHTGVVPLDLVKCRIQVDPQKYKNIFNGFSVTIKEDGVRAPMEAAKVRIQTQAGYANTLRQAAPKMYAEEGVWAFYKGVVPLWMRQIPYTMMKFACFERTVEALYKYVVPKPRSECSKAEQLVVTFIAGYIAGVFCAIVSHPADSVVSVLNKEKGSSASQVLVRLGFRGVWKGLFARIIMIGTLTALQWFIYDSVKVYFKLPRPPPPEMPESLKKKLGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1H8</accession>
    <name>A0A151M1H8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0008488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006817">
        <property type="protein sequence ID" value="KYO18361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1H8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF206">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="222"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO18361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="379" mass="43006" checksum="BE915884A38CB5E5" modified="2016-06-08" version="1">MARRQGVLRTAGIRYITHGLLTLTRQREALERVLLPTRTEPCVLPLHPCPPSIHDCVSRFLLEDDDEALLDAMNAGVLWDHLHTVERKVWAHPSSTDWWERVVLGTWDDELWLQTFRMRRDTFMDIAAQVAPHIARQDIVMRPTLSPEKRVAIAVLKLATPGSLRYIANQFGVGRSTAGEAVREVCLVIQDVLANRFIRLINPQEVVAGFRCMGFPNCVGAMDSTHIPIVCPPQGGQAFINRKGYYSVILQGVVDHRGRFTHIYAGWAGSAHDARVFRNSPLPNLMESGRYASGLPDCVIGDVVIPPLIIGNPAYPFLPWLMKPYEGQLDRRKEHFNQCLSRGEVFLESWAEEAQRTDRACQRERTRRRDTDEDRGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M1W2</accession>
    <name>A0A151M1W2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E3 ubiquitin-ligase pellino-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PELI1</name>
        <name evidence="5" type="ORF">Y1Q_0014778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pellino family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006807">
        <property type="protein sequence ID" value="KYO18505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M1W2"/>
    <dbReference type="STRING" id="8496.A0A151M1W2"/>
    <dbReference type="eggNOG" id="KOG3842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038886">
        <property type="entry name" value="Pellino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="4">
        <location>
            <begin position="254"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO18505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="397" mass="43919" checksum="6FF8565594F4D200" modified="2016-06-08" version="1">MSRYNGSLPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNNDETQITQSTISRFACRIVCDRNPPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPKGGFTEESKPGVWREISVCGDVYTLRETRSAQQRGKLVENETNVLQDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKDVVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCAAQLSGEHNCVKLIFQGPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2I1</accession>
    <name>A0A151M2I1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein unc-93 homolog A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UNC93A</name>
        <name evidence="9" type="ORF">Y1Q_0009161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006780">
        <property type="protein sequence ID" value="KYO18719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2I1"/>
    <dbReference type="STRING" id="8496.A0A151M2I1"/>
    <dbReference type="eggNOG" id="KOG3097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17406">
        <property type="entry name" value="MFS_unc93A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000290">
        <property type="entry name" value="Unc-93 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO18719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="886" mass="100229" checksum="FDF370D75EE02B91" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M2Y1</accession>
    <name>A0A151M2Y1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0018869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO18885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M2Y1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="64"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="239"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO18885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="494" mass="58751" checksum="B8D66D93ED80247B" modified="2016-06-08" version="1">MQSEAPPVLQYKDMLRWKKGFCTCVSDYWDSRKASSREDYLRMEPSEKYLFKYKGIYFYPDYLHIPNQELCPRGLKNRRLKVIYVSRNPKDVLVSFFHFSKTVITLEEIPDFNIFMERFLAGKVHSSSWLDHVRGWYDHRDEFSIFFLTYEEMIKDLRGVVLRICDFLGKELSEDDLDAVVKKATFENMKKDPRANYETMPGDLLEKDKGHFLRKGIYFYTDYVTPESIDSLEEFEIRDSDVFLITYPKSGTVWTQNILSLIFHEGHRDETEDIHVIDRVPWLEYNLNKLDYANRPSPRLFTTHLPYYLVPRGLKNKRVKVIYVARNPKDVLVSYFHFSKTVITPDNPPDFSIFMERFLAGEVLSSSWLDHVRGWYDHRDDFNILFLTYEEMKKDLRGAVLRICNFLGKELSEDDLDPVVKKATFENMKKDPRANYETRPGVPLEEKKCFLRKGTVGDWKNTMTVAQNERFEEVLKEKMKDLPFNYIWDNEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3B4</accession>
    <name>A0A151M3B4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS-type transporter SLC18B1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC18B1</name>
        <name evidence="9" type="ORF">Y1Q_0018974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006769">
        <property type="protein sequence ID" value="KYO19023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270596.1">
        <property type="nucleotide sequence ID" value="XM_006270534.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3B4"/>
    <dbReference type="STRING" id="8496.A0A151M3B4"/>
    <dbReference type="GeneID" id="102560178"/>
    <dbReference type="KEGG" id="amj:102560178"/>
    <dbReference type="CTD" id="116843"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="PhylomeDB" id="A0A151M3B4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17385">
        <property type="entry name" value="MFS_SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="31"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO19023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="458" mass="49341" checksum="9512625C60E02F77" modified="2016-06-08" version="1">MGSREAVPPENGGPEVLSKESGRLTREQLFTIIATASINFSSMICYSILGPFFPREALKKGASNTVVGLIFGCFALFNFLTSLILGKYLVQIGAKFMFVTGMFMSGCVTILFGMLDKVPDGPVFIGLCFLVRAVDAIGFAAAMTASFSILANAFPNNIATVLGSLEIFSGLGLVLGPPLGGFLYQSFGYEIPFIVLGCVVLILVPLNMYILPKYDSAPSKDSFWKLILLPKVVLLCLAIFSLSGCLGFLDPTMSLFVSEKFKLPAGYVGLVFLGLALSYSLSSPLLGVLSDKMPHLRKWLMVFGGLLTAVCYFLLGPAPVLHIESQLWMFVLMLVLIGFSLGMTGIPLFPEVISCAYENGFEEGLSLLGLVSGLFSAVWSLGSFVGPTLGGFLNDKLGFEWAATIQGGWPLLSGLGIGIFYILETSQRKRSNLQNPPDTNEERAHLLGSETQPEILLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M3Y9</accession>
    <name>A0A151M3Y9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0018210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006661">
        <property type="protein sequence ID" value="KYO19227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M3Y9"/>
    <dbReference type="STRING" id="8496.A0A151M3Y9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO19227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="116" mass="13368" checksum="8FAFDA9FCE690718" modified="2016-06-08" version="1">MLCPDISLLYPQGPVASRGPPGEVIQHLPIQLPKKRKWSIDANHLMEEEEKEEEAEAGLGRWVLVTKDMEEVFGSLHTIKQETEQLQHCEYTCDIYACTWQDLQLCWSGFPDCRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M553</accession>
    <name>A0A151M553_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CCDC18</name>
        <name evidence="6" type="ORF">Y1Q_0007520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006584">
        <property type="protein sequence ID" value="KYO19601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M553"/>
    <dbReference type="eggNOG" id="ENOG502QTZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="PhylomeDB" id="A0A151M553"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875:SF8">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="204"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="530"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1065"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1184"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO19601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1394" mass="162066" checksum="05DBFE32DD0D7D5C" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M5T3</accession>
    <name>A0A151M5T3_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">DEAH-box protein 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Y1Q_0006834</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of pre-catalytic spliceosome complexes. Component of the minor spliceosome, which splices U12-type introns. Interacts with GPKOW. Interacts with TRIM6. Interacts with RIGI.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03006526">
        <property type="protein sequence ID" value="KYO19872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M5T3"/>
    <dbReference type="STRING" id="8496.A0A151M5T3"/>
    <dbReference type="eggNOG" id="KOG0923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17974">
        <property type="entry name" value="DEXHc_DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000818">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="364"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="24">
        <location>
            <begin position="553"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="74"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KYO19872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="996" mass="114819" checksum="55354A18DD2C1C85" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M638</accession>
    <name>A0A151M638_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DTX3</name>
        <name evidence="10" type="ORF">Y1Q_0011414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Deltex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EMBL" id="AKHW03006462">
        <property type="protein sequence ID" value="KYO19985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M638"/>
    <dbReference type="STRING" id="8496.A0A151M638"/>
    <dbReference type="eggNOG" id="ENOG502QUYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.130:FF:000001">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Deltex C-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO19985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="147" mass="16310" checksum="8EB48038788C23DF" modified="2016-06-08" version="1">MCGRFYGRLVGNQPENGRMLVSKDSGLLLPGYEKYGTIIIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLGLFRKAFDQRLTFTIGTSMTTGRANVITWNDIHHKTNCTGGPQLFGYPDPTYLSRVQEELRAKGITED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M6B8</accession>
    <name>A0A151M6B8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0010654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006437">
        <property type="protein sequence ID" value="KYO20063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M6B8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO20063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="131" mass="14738" checksum="6CD56ABDD1DA6416" modified="2016-06-08" version="1">MGSGQAQNGAFMGELYCRVAEEWLHLRARDTLPSSGRWHCRPAPASSPAHFKPAPLLCPALSHSKLEENRLVPVVPFSYVFWDNTCVIQMASLERGRAADRHIFELLHLFKIQQEYAASKLTCTKEISKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M7P1</accession>
    <name>A0A151M7P1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fanconi anemia group A protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FANCA</name>
        <name evidence="5" type="ORF">Y1Q_0015378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006373">
        <property type="protein sequence ID" value="KYO20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151M7P1"/>
    <dbReference type="eggNOG" id="ENOG502QT8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045589">
        <property type="term" value="P:regulation of regulatory T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003516">
        <property type="entry name" value="FANCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055387">
        <property type="entry name" value="FANCA_arcN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055386">
        <property type="entry name" value="FANCA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055277">
        <property type="entry name" value="Fanconi_A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031729">
        <property type="entry name" value="Fanconi_A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12047">
        <property type="entry name" value="FANCONI ANEMIA GROUP A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12047:SF2">
        <property type="entry name" value="FANCONI ANEMIA GROUP A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24783">
        <property type="entry name" value="FANCA_arcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03511">
        <property type="entry name" value="FANCA_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24781">
        <property type="entry name" value="FANCA_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15865">
        <property type="entry name" value="Fanconi_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00826">
        <property type="entry name" value="FANCONIAGENE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi anaemia group A protein N-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Fanconi anaemia group A protein helical" evidence="3">
        <location>
            <begin position="514"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Fanconi anaemia group A protein arcN subdomain" evidence="4">
        <location>
            <begin position="617"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Fanconi anaemia group A protein C-terminal" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1432" mass="161338" checksum="25C3211A5BE1E3F9" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151M983</accession>
    <name>A0A151M983_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Perilipin-1 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PLIN1-1</name>
        <name evidence="5" type="ORF">Y1Q_0001392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the perilipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006295">
        <property type="protein sequence ID" value="KYO21088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151M983"/>
    <dbReference type="STRING" id="8496.A0A151M983"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042998">
        <property type="entry name" value="PLIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47138">
        <property type="entry name" value="PERILIPIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47138:SF1">
        <property type="entry name" value="PERILIPIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO21088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="557" mass="60274" checksum="6C896184F6F27C83" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MBR5</accession>
    <name>A0A151MBR5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006283">
        <property type="protein sequence ID" value="KYO21850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MBR5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO21850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="92" mass="10271" checksum="5DF98A0399A54FEA" modified="2016-06-08" version="1">MKGSGSRSGLPFTHSFHLVQVAKWVEGSWESWSQSPVCWSILPTWNGTAREEGAAIGVPRGRLAPSGEPAFSFQLLKKISQLYFRAQREHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MEZ8</accession>
    <name>A0A151MEZ8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box/WD repeat-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FBXW5</name>
        <name evidence="3" type="ORF">Y1Q_0005556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MEZ8"/>
    <dbReference type="STRING" id="8496.A0A151MEZ8"/>
    <dbReference type="GeneID" id="102564597"/>
    <dbReference type="KEGG" id="amj:102564597"/>
    <dbReference type="CTD" id="54461"/>
    <dbReference type="eggNOG" id="ENOG502QTGQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192402at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22132">
        <property type="entry name" value="F-box_FBXW5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000305">
        <property type="entry name" value="F-box/WD repeat-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000335">
        <property type="entry name" value="F-box/WD repeat-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042508">
        <property type="entry name" value="FBXW5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995:SF17">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO23097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="591" mass="67444" checksum="87FB6884FE7ED781" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MF14</accession>
    <name>A0A151MF14_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0005572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MF14"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO23122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="102" mass="11693" checksum="F8AE67E624AB0C34" modified="2016-06-08" version="1">MSEREGWKAFELVVALAGCQAGGTWWMDKLGDLVGGWLMTALNIPYKKWALDQASLSTVLQAAEWKESPLIYFPWLREFLADLTMVILTILRRNLWTSNVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MFV8</accession>
    <name>A0A151MFV8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol polyphosphate 5-phosphatase type IV</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
            <ecNumber evidence="3">3.1.3.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">72 kDa inositol polyphosphate 5-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Inositol polyphosphate-5-phosphatase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Phosphatidylinositol 4,5-bisphosphate 5-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">INPP5E</name>
        <name evidence="18" type="ORF">Y1Q_0005780</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25528"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="EC" id="3.1.3.86"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32955"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:32956"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22765"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts (when prenylated) with PDE6D; this is important for normal location in cilia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EC" id="3.1.3.86" evidence="3"/>
    <dbReference type="EMBL" id="AKHW03006215">
        <property type="protein sequence ID" value="KYO23405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MFV8"/>
    <dbReference type="STRING" id="8496.A0A151MFV8"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09095">
        <property type="entry name" value="INPP5c_INPP5E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000039">
        <property type="entry name" value="72 kDa inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042478">
        <property type="entry name" value="INPP5E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46625">
        <property type="entry name" value="72 KDA INOSITOL POLYPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46625:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL POLYPHOSPHATE 5-PHOSPHATASE TYPE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="17">
        <location>
            <begin position="103"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO23405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="450" mass="51590" checksum="FC3A1307EBBAC0AE" modified="2016-06-08" version="1">MEIDVVSRALRTAHRIDSDCTDYWRGSGSKLVRQSGGSLSDTRLHGSGMVCDSCSTDSMKSSFSLLAPIRAKDVRSRSYLEGSLLASGALLGAEELNRYFPDRTIGIFVATWNMQGQKELPENLDDLLLPTDPDYAQDMYIIGVQEGCPDRREWEIRLQETLGPHYVMLFSAAHGVLYMSVFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSGDSKVYERILDYNKIIQALALPKNVPDTNPYRSSPSDVTTRFDEVFWFGDFNFRLNQDREAVNLILNQNLEMDMSKLLQYDQLLKEMKNGSVFKGFQEAAIHFHPSYKFDIGQDCYDTTSKQRTPSYTDRVVYRSRHKNDIHAVKYSSCPIIRTSDHRPVYGLFRVKLRPGRDNIPLAAGQFDRELYLFGIKRRITRDLKKRQELKDQKSSRVCTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MHK4</accession>
    <name>A0A151MHK4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0015865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006164">
        <property type="protein sequence ID" value="KYO23880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MHK4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO23880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="10508" checksum="0D251C122D4F9435" modified="2016-06-08" version="1">MLLGTTVTFEDNFSKILSYQDDFGAVLSGHSSTRCRSTTIALSNHIAGGAAWDFKSQRRMPTKSCFPEHNKSKQQEETQHSTIFKEDLKRNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MI13</accession>
    <name>A0A151MI13_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cerebral cavernous malformations 2 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCM2L</name>
        <name evidence="4" type="ORF">Y1Q_0020284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03006102">
        <property type="protein sequence ID" value="KYO24171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MI13"/>
    <dbReference type="STRING" id="8496.A0A151MI13"/>
    <dbReference type="GeneID" id="102562378"/>
    <dbReference type="KEGG" id="amj:102562378"/>
    <dbReference type="CTD" id="140706"/>
    <dbReference type="eggNOG" id="ENOG502QW6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5828470at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13516">
        <property type="entry name" value="HHD_CCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13166">
        <property type="entry name" value="PTB_CCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.20:FF:000004">
        <property type="entry name" value="Cerebral cavernous malformation 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032375">
        <property type="entry name" value="CCM2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026159">
        <property type="entry name" value="Malcavernin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21642:SF2">
        <property type="entry name" value="CEREBRAL CAVERNOUS MALFORMATIONS 2 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21642">
        <property type="entry name" value="CEREBRAL CAVERNOUS MALFORMATIONS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16545">
        <property type="entry name" value="CCM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cerebral cavernous malformations 2 harmonin-homology" evidence="3">
        <location>
            <begin position="402"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO24171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="564" mass="63309" checksum="9605F2761EFFAC09" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MI83</accession>
    <name>A0A151MI83_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="35">DEAH box protein 9</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
            <ecNumber evidence="9">4.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="36">Nuclear DNA helicase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="primary">DHX9</name>
        <name evidence="44" type="ORF">Y1Q_0004283</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="44 45" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="44">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="44">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
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    <sequence length="1546" mass="171859" checksum="24C9946BCDCFD5D0" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005924">
        <property type="protein sequence ID" value="KYO25104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MKP9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9032" checksum="7FFADD8E8C3FBEBB" modified="2016-06-08" version="1">MKTTTGSALVLSKTLLQGSSDLPAALTTSNSSSDPWILFIFHIAAWTSGRKKTCPTASQMSLPTCFYSFPDLCEQLETSVGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MLX3</accession>
    <name>A0A151MLX3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0023962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005753">
        <property type="protein sequence ID" value="KYO25526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MLX3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO25526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="154" mass="16806" checksum="188919737E9E4F03" modified="2016-06-08" version="1">MEGPASLGQELSQSCSSPSLSCCSSSVDLNSSLESRSPPTPGTSITVISSLAGEETKGMEEEEEDQGKDWKSLEEAAVIIRKHLQEPGEELMEDVSMEEDLGNILPDSIAAILYLSNCVMPAGEQQDTWSRRGFYYVISHPRLNRLVACVQKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN12</accession>
    <name>A0A151MN12_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superoxide dismutase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CCS</name>
        <name evidence="10" type="ORF">Y1Q_0006975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005658">
        <property type="protein sequence ID" value="KYO25912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN12"/>
    <dbReference type="STRING" id="8496.A0A151MN12"/>
    <dbReference type="eggNOG" id="KOG4656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000004">
        <property type="entry name" value="Copper chaperone for superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO25912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="277" mass="28964" checksum="ECAE3500472B224A" modified="2016-06-08" version="1">MGCSVPGWAGSSPGLGLEFTVQMSCQGCVDAIGASLQGVPGLRVLDVRLDTQSVLLETSLGAEQVKELLESSGRRAVLKGMGGSMTQNLGAAVAMMAGPSLVQGVVRFLQVSQEKCLIEGTIDGLAPGPHGLHVHEFGDMTSSCDSCGEHFNPEAECHGGPLDEHRHLGDLGNVLADNDGRATFRLEDARLKVWDIIGRSLVVDAGEDDLGRGAHPLSKVTGNSGERLACGIIACSAGLFENPKQICACDGVTIWEERDRPLAGPGRRVPGQPAPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MN26</accession>
    <name>A0A151MN26_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO25951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MN26"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO25951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="71" mass="7833" checksum="C32FA229BD53268C" modified="2016-06-08" version="1">MEGPPGAVLERPRALQHPATRIAGLLDWCFEKAVLSKHLFPRLFTMASGRCSVVLQPQQNGTPFQGKNMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNF6</accession>
    <name>A0A151MNF6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0003824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNF6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="82" mass="9398" checksum="5406A499185F4239" modified="2016-06-08" version="1">MLLWKLEQQMGFLFHCTHPSHPLLCPLLAGDPPRTAGCICLNSPACSDFTNMDEREWMADIHINLLNDAPFNNSFFLQEQCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MNN6</accession>
    <name>A0A151MNN6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH HARE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0003900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005657">
        <property type="protein sequence ID" value="KYO26157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MNN6"/>
    <dbReference type="STRING" id="8496.A0A151MNN6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035517">
        <property type="term" value="C:PR-DUB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042975">
        <property type="term" value="F:peroxisome proliferator activated receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF18">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN ASXL3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO26157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="66" mass="7630" checksum="C22C261082B4034B" modified="2016-06-08" version="1">MKDKRKKKDRTWAEAARLALEKHPNSPMTAKQILEVIQKEGLKETSCKKIIIWAILLSVPGRKNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPQ3</accession>
    <name>A0A151MPQ3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0002154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPQ3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="110" mass="11789" checksum="AFE50C6A4C252A7D" modified="2016-06-08" version="1">MAGRPDQVQRGGVVSPRMDSTNTRLMGKSNIIIENRNLLASLLNSAAFSKLPIVAADFTLKHQCESTGLIYCAFPGVDEMPQPLKSKSSVLPAGCASPDPFPCGTVHQWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MPY9</accession>
    <name>A0A151MPY9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-X-C motif chemokine 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0002168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intercrine alpha (chemokine CxC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005470">
        <property type="protein sequence ID" value="KYO26543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MPY9"/>
    <dbReference type="STRING" id="8496.A0A151MPY9"/>
    <dbReference type="KEGG" id="amj:102558077"/>
    <dbReference type="OrthoDB" id="8872899at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MPY9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00273">
        <property type="entry name" value="Chemokine_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000004">
        <property type="entry name" value="C-X-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001089">
        <property type="entry name" value="Chemokine_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033899">
        <property type="entry name" value="CXC_Chemokine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF198">
        <property type="entry name" value="PLATELET BASIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00436">
        <property type="entry name" value="INTERLEUKIN8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00437">
        <property type="entry name" value="SMALLCYTKCXC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028117705" evidence="5">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="6">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO26543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="109" mass="12277" checksum="D8910B2D8ECEDD45" modified="2016-06-08" version="1">MKSLATVLVIALLVKNLIVLEGLPLESLLTYHRCKCLKETSNIIRLTSILSINVMPPGIHCRKKEIILTLKGDKKVCVNPSAPWIQALLQHLTQRKALQNNSKQVMYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQ40</accession>
    <name>A0A151MQ40_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PEX1</name>
        <name evidence="15" type="ORF">Y1Q_0019136</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006270205.2">
        <property type="nucleotide sequence ID" value="XM_006270143.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQ40"/>
    <dbReference type="STRING" id="8496.A0A151MQ40"/>
    <dbReference type="GeneID" id="102562661"/>
    <dbReference type="KEGG" id="amj:102562661"/>
    <dbReference type="CTD" id="5189"/>
    <dbReference type="eggNOG" id="KOG0735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8173462at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MQ40"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000067">
        <property type="entry name" value="Peroxisomal biogenesis factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000966">
        <property type="entry name" value="Peroxisomal biogenesis factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001852">
        <property type="entry name" value="Peroxisomal biogenesis factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000060">
        <property type="entry name" value="peroxisome biogenesis factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000004">
        <property type="entry name" value="Peroxisome biogenesis factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015343">
        <property type="entry name" value="PEX1-N-lobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09263">
        <property type="entry name" value="PEX-2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="586"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="868"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1260"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KYO26655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1279" mass="142278" checksum="F55478DF8B45331D" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MQS1</accession>
    <name>A0A151MQS1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0019316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MQS1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO26884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="86" mass="10093" checksum="0765F387D08A7FD0" modified="2016-06-08" version="1">MFPTSGETIRPYYALLKCLCNRHLLITGERRDAAHVGDCITSSSPWWYKVTWNIRTVRSERGWTVHLLCAIFTHQTMVFSCNREQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR68</accession>
    <name>A0A151MR68_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Y1Q_0018203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="AKHW03005442">
        <property type="protein sequence ID" value="KYO27041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR68"/>
    <dbReference type="STRING" id="8496.A0A151MR68"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF435">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KYO27041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="214" mass="24827" checksum="008DDC780571D3B1" modified="2016-06-08" version="1">MREVWRHLQELLNHKIITESKSPYALAIVIVRKKNGNLQMCIDYHVLNARMVVNQYTVPQVQEALDYLGGSKWFTMLDLRSGYYQIPLREPDKKKTAFICPLGFFQFECMPQGISGAPAMFHHLMEKVVIDMHLNQVLVYLDDLIVFGKTLEEHDERLLCMLDHLEAAGLRSMLDKCKFCQASVKYVRHIISQNGVSTYLEKVKAMTTWPRPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MR72</accession>
    <name>A0A151MR72_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0019327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005461">
        <property type="protein sequence ID" value="KYO26900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MR72"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO26900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="393" mass="43591" checksum="2769A37BDF994717" modified="2016-06-08" version="1">MQLVSRIFIQLRLANDVTGNHRLAVIKMAGGGGKRRGRMDPGSVGTPDPFRDSLREEEALEGEPEEAPDASHGNSSRKQIVNAGDELEAAPAICKGSSIRGGSEGHAKALTITGVSIGNSEEEEEFSPQRESRQEQQEGPQRSRALTLNTENSKPHAEELQGTQIGMLWKGEKRGSTRLIEEVEMGEGKTRAGGHQCTTPNGVPYIVGRKLMNAFLLYKETVTFIYGSLTGAYNYRKCKATEQQPRKTHKWNGEFLGVFTQFLLPGLEGARDRGKVMVDATSISEDHTYCWNEEEQISEELGCVGNCNPWGGQQYSTAHWRWMRQKQIATDVKAAVTRKDLPAAHQGEAIDRTDKQTSKTHDHLKQTVPWILFGNNNQTLKKKTFASSNKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MRQ4</accession>
    <name>A0A151MRQ4_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ceramide synthase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CERS5</name>
        <name evidence="19" type="ORF">Y1Q_0011168</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005250">
        <property type="protein sequence ID" value="KYO27215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006264674.1">
        <property type="nucleotide sequence ID" value="XM_006264612.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MRQ4"/>
    <dbReference type="STRING" id="8496.A0A151MRQ4"/>
    <dbReference type="GeneID" id="102569929"/>
    <dbReference type="KEGG" id="amj:102569929"/>
    <dbReference type="CTD" id="91012"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MRQ4"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF8">
        <property type="entry name" value="CERAMIDE SYNTHASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="17">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="18">
        <location>
            <begin position="130"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO27215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="384" mass="44864" checksum="E1CAB80CF0953E07" modified="2016-06-08" version="1">MAAAAALLSAWFWDERFWLPRNVTWADVAGRSPRAGLVACAFPLALGIFAVRLLFERFIAKPCAINLGIQDSGPHRAQPNAILEKVFTSITKSPDGRRLEGLSKQLDWDVRKIQRWFRHRRNQDKPTILTKFCESMWRFTFYLSIFSYGIRFLWSTPWFWDTRQCWYNYPFQPLTSSLYYYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLATIGLITFSYMNNMVRVGTLVLCLHDASDFLLEAAKLANYAKYQRVCDATFMLFSVVFIVTRLGIYPYWILNTTLFESWELIGPYPSWWLFNGLLVTLQVLHIIWSYLIIRIAYKALMRGKVSKDDRSDVESSSEEEDTTSNSTKGNFCTSSNGANRINGHITTGQWAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MS47</accession>
    <name>A0A151MS47_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Solute carrier family 12 member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Y1Q_0021262</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005226">
        <property type="protein sequence ID" value="KYO27345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MS47"/>
    <dbReference type="STRING" id="8496.A0A151MS47"/>
    <dbReference type="KEGG" id="amj:102559485"/>
    <dbReference type="eggNOG" id="KOG2082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MS47"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000049">
        <property type="entry name" value="Solute carrier family 12 (potassium/chloride transporter), member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000040">
        <property type="entry name" value="Solute carrier family 12 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000622">
        <property type="entry name" value="KCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF46">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01081">
        <property type="entry name" value="KCLTRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01082">
        <property type="entry name" value="KCLTRNSPORT1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="130"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="18">
        <location>
            <begin position="423"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="715"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="19">
        <location>
            <begin position="845"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO27345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121600" checksum="B80B3F663CADFFDE" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MSA5</accession>
    <name>A0A151MSA5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0021229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005226">
        <property type="protein sequence ID" value="KYO27299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MSA5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO27299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="118" mass="13564" checksum="1098F3B40F5F0B78" modified="2016-06-08" version="1">MLLFWTEKLASLLKTSTPILEGYFLEKSVWDAWQFPICDVLRVLLSQFPVRALRSQKQSQCHSTSGSIKVHQTSTAPSKHSDRLSQPTWKHKHYKATATSSFIFFVIRKLQQQERGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MU24</accession>
    <name>A0A151MU24_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0014214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03005050">
        <property type="protein sequence ID" value="KYO28031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MU24"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO28031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11198" checksum="08831D3616E9F281" modified="2016-06-08" version="1">MQPPLTLEKQVIITIMNLATPNSLQYITNQFGMGKSMAREEVCLVIQNILANCFICLINPQEVVTGFCQKGFPNNMGALDSTHIRTICLPQGPRLFINCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MV36</accession>
    <name>A0A151MV36_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Phospholipase A2</fullName>
            <ecNumber evidence="4 13">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Y1Q_0015997</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The N-terminal C2 domain associates with lipid membranes upon calcium binding.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="4 13"/>
    <dbReference type="EMBL" id="AKHW03004924">
        <property type="protein sequence ID" value="KYO28406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MV36"/>
    <dbReference type="STRING" id="8496.A0A151MV36"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04036">
        <property type="entry name" value="C2_cPLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07201">
        <property type="entry name" value="cPLA2_Grp-IVB-IVD-IVE-IVF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000030">
        <property type="entry name" value="Phospholipase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000002">
        <property type="entry name" value="Phospholipase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041847">
        <property type="entry name" value="C2_cPLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040723">
        <property type="entry name" value="cPLA2_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF67">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18695">
        <property type="entry name" value="cPLA2_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12 13" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10 12 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="82"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="15">
        <location>
            <begin position="356"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KYO28406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="902" mass="103751" checksum="0F7A17FEA81217EC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MVA4</accession>
    <name>A0A151MVA4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Long-chain-fatty-acid--CoA ligase ACSBG2</fullName>
            <ecNumber evidence="10">6.2.1.15</ecNumber>
            <ecNumber evidence="11">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Acyl-CoA synthetase bubblegum family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Arachidonate--CoA ligase ACSBG2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Y1Q_0016907</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33607"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33608"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33651"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33652"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="10"/>
    <dbReference type="EC" id="6.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="AKHW03004903">
        <property type="protein sequence ID" value="KYO28481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MVA4"/>
    <dbReference type="STRING" id="8496.A0A151MVA4"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF101">
        <property type="entry name" value="ACYL-COA SYNTHETASE BUBBLEGUM FAMILY MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="40"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KYO28481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="467" mass="50816" checksum="FB3DE6A24B94D3DF" modified="2016-06-08" version="1">MPAPLGASIHHPLAAAMCCGAQSGVVTSMSLGGICDEILLQTLGLERFHGVTILGSNSPEWVIADIGAIMAGGLAVGVYSTSSPEACGYIAANCEANVVVVEDNAQLSKILQVQKQLPHLKAIIQYRDSLEEKRPNVYTWEEFMELGRTVPDSQLDSIIRSQCVNHCCTLIYTSGTTGTPKGVMLSHNNGSLLPTLKEVRPTFLFAVPHVWEKMEEKLKATFSQSPLVKRKLVEWARGIGLQASYSRLDGSRIKQPDVEGTSELCCWGCHVFMGYLGMEAATQEALDKAGWLRTGDLACCDPDGFRYIVGKIKELVITAGRKNIAPVPIEEAVKREVPIISNAILVGDGRKFLSMLLTLKCKVDPESGAPLDELSPEAMQFFQELGSQATRVSEVLSTRDPAVYQAIQQGVEQVNQRALSRTHHVQKWAVLPRDFSIAGGELGPTAKLKCRVVLGAYETRISGCYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MWI0</accession>
    <name>A0A151MWI0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HAUS augmin-like complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HAUS1</name>
        <name evidence="11" type="ORF">Y1Q_0009717</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004724">
        <property type="protein sequence ID" value="KYO28860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014449624.1">
        <property type="nucleotide sequence ID" value="XM_014594138.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MWI0"/>
    <dbReference type="STRING" id="8496.A0A151MWI0"/>
    <dbReference type="GeneID" id="102558004"/>
    <dbReference type="KEGG" id="amj:102558004"/>
    <dbReference type="CTD" id="115106"/>
    <dbReference type="eggNOG" id="ENOG502QSQA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="PhylomeDB" id="A0A151MWI0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02087">
        <property type="entry name" value="HAUSAUGMINL1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO28860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="286" mass="32959" checksum="6282DAFD46607ED1" modified="2016-06-08" version="1">MEEKLARVTLWLKKVYGDQPVPQYKVNARSVDILHQLAECNETRDRDVSLLIDDVKQKTAEYELEANYLQDLLAQSVNLSLTCLSKMGTHYLNALVDSAMALETKDTSLASFIPAINDLTSDLHKVESRNRELELELTTFREKLTKALVLEKRLQDDLKKTEEHVMVEKAKADSRTQNMKFLKNKSEDFKFRIKAAEEQLVANRMDPSLTHESLVSLSEKLAELKQQTRPLKKKLKSYLDLTPNPSLARVKIEEVKRELNALEEEFSAKVDMMALSVPEPRKHRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MXJ0</accession>
    <name>A0A151MXJ0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0017639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004711">
        <property type="protein sequence ID" value="KYO29224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MXJ0"/>
    <dbReference type="STRING" id="8496.A0A151MXJ0"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF3">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO29224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="101" mass="11376" checksum="972243831BAD9658" modified="2016-06-08" version="1">MLPTKSSFSFCLLLLQGKTPSPRAAHACATVGNRGYVFGGRYRDSRMNDLYYLNLDTWEWNETITQGICPVGRSWHSLTPISSDHLFLFGGFTTDKQPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYC8</accession>
    <name>A0A151MYC8_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0022700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004688">
        <property type="protein sequence ID" value="KYO29458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYC8"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO29458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="131" mass="15290" checksum="13A8F1E7EFB24A06" modified="2016-06-08" version="1">MSTWDLQSLRDSHPAEAKVLLTVPYLSNRIQGNDSISLRLDTNDRRDLRVQPAGRGQQYKFRVQEHFRLIKWSAVKLQELDDHSFARCDLKEDMVMCSMAPLCTEIPMVFRSSLRFIDPHQLLATGWSQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151MYJ7</accession>
    <name>A0A151MYJ7_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cadherin-22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Y1Q_0015220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004604">
        <property type="protein sequence ID" value="KYO29626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151MYJ7"/>
    <dbReference type="STRING" id="8496.A0A151MYJ7"/>
    <dbReference type="eggNOG" id="KOG3594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000007">
        <property type="entry name" value="Cadherin 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF311">
        <property type="entry name" value="CADHERIN-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin Y-type LIR-motif" evidence="10">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KYO29626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="200" mass="21790" checksum="ADB603B54BE8A865" modified="2016-06-08" version="1">MTATLSPGALIALLVCILILVVLVLLILTLKRHHKSHLASEEDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFSEIKGGDGGGGAGDGGLSSSLASELHALPQWVQSPDLDFSMFRDYISKKVEQADEDPSVPPYDSFQTYAFEGADSPVPSLSSINTWSTSSEQDFSYLGSWGPRFRQLATLYAGHKGEEEGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N0W5</accession>
    <name>A0A151N0W5_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0017658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004172">
        <property type="protein sequence ID" value="KYO30414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N0W5"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO30414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="125" mass="14190" checksum="D5C6559B63BA839B" modified="2016-06-08" version="1">MVIQEDYLQKLPVVMAPRGSWCHDSDPEHVLRKEDRGPFPAEPRVPNLRADQSPLASLSNLAFLQNQAPKQEKNDWQRAGSPDVDCKKVSPPLDPKATEFQPRLRPFPEAKDKDPQDLTQASEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N1C0</accession>
    <name>A0A151N1C0_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase SMG1</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SMG1</name>
        <name evidence="23" type="ORF">Y1Q_0008221</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="AKHW03004154">
        <property type="protein sequence ID" value="KYO30574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151N1C0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05170">
        <property type="entry name" value="PIKKc_SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000136">
        <property type="entry name" value="serine/threonine-protein kinase SMG1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000010">
        <property type="entry name" value="serine/threonine-protein kinase SMG1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000008">
        <property type="entry name" value="serine/threonine-protein kinase SMG1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035175">
        <property type="entry name" value="SMG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039414">
        <property type="entry name" value="SMG1_PIKKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF71">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17229">
        <property type="entry name" value="SMG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="21">
        <location>
            <begin position="1291"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="20">
        <location>
            <begin position="2126"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="22">
        <location>
            <begin position="3596"/>
            <end position="3628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1899"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="3536"/>
            <end position="3558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1976"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="3536"/>
            <end position="3546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KYO30574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="3628" mass="406692" checksum="102B64EED6F431C8" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N2F8</accession>
    <name>A0A151N2F8_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Hydroxyacylglutathione hydrolase, mitochondrial</fullName>
            <ecNumber evidence="7">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HAGH</name>
        <name evidence="20" type="ORF">Y1Q_0014346</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:25246"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:21865"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="7"/>
    <dbReference type="EMBL" id="AKHW03004153">
        <property type="protein sequence ID" value="KYO30829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N2F8"/>
    <dbReference type="STRING" id="8496.A0A151N2F8"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000019">
        <property type="entry name" value="Hydroxyacylglutathione hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF80">
        <property type="entry name" value="HYDROXYACYLGLUTATHIONE HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="19">
        <location>
            <begin position="51"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KYO30829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="308" mass="34385" checksum="0BE5FF85145CDFAE" modified="2016-06-08" version="1">MCAQDSPAPKDRSAGSAPLWACFFHTEFELRKPKTVTQADMKVELLPALTDNYMYLLIDEETKEAAIVDPVQPQKVLEAAQKHGVKLTTVLTTHHHWDHAGGNEKLVKMQAGLKVYGGDSRVGALTQKVSHLTSFKVGSLHVKCLSTPCHTSGHICYYVTKPSSSEPPAVFTGDTLFVAGCGKFFEGTPDEMYRALIEVLGRLEPETRVYCGHEYTINNLKFARHVEPNNTAVHEKLAWAKAKYDSGEPTIPSTIAEEFAYNPFMRVREKTVQQHARETDPIRTMGAIRKEKDNFRAGRDQDPGKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3L2</accession>
    <name>A0A151N3L2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">STRA6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">STRA6L</name>
        <name evidence="9" type="ORF">Y1Q_0009069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004080">
        <property type="protein sequence ID" value="KYO31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3L2"/>
    <dbReference type="STRING" id="8496.A0A151N3L2"/>
    <dbReference type="GeneID" id="102563798"/>
    <dbReference type="KEGG" id="amj:102563798"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2376984at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034632">
        <property type="term" value="F:retinol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071939">
        <property type="term" value="P:vitamin A import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF17">
        <property type="entry name" value="STIMULATED BY RETINOIC ACID GENE 6 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="617" mass="70784" checksum="1A67B47A6D91ED04" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N3W2</accession>
    <name>A0A151N3W2_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium-binding protein 2 isoform A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CABP2</name>
        <name evidence="6" type="ORF">Y1Q_0016982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004108">
        <property type="protein sequence ID" value="KYO31269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N3W2"/>
    <dbReference type="STRING" id="8496.A0A151N3W2"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000069">
        <property type="entry name" value="calcium-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000037">
        <property type="entry name" value="calcium-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043582">
        <property type="entry name" value="CaBP1/2/4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45917:SF10">
        <property type="entry name" value="CALCIUM BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45917">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KYO31269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="217" mass="24645" checksum="9E5579E9E30978A8" modified="2016-06-08" version="1">MGNCTKTPERRLSKDSKQRSGAPAPGLYDPEDLIDAAQSPPLQSYSVLHGLVGPACIFLRQSIAITQLDRDLRPEEIEELKQAFREFDKDRDGFISYKDLGECMRTMGYMPTEMELIELSQQISGGKVDFDDFVELMGPKMLAETADMIGIKELRDAFREFDTNGDGQISMAELREAMRKLLGQQLNYREVDEILKDVDLNGDGLVDFEEFVRMMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N4U6</accession>
    <name>A0A151N4U6_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Splicing factor 3A subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SF3A1</name>
        <name evidence="17" type="ORF">Y1Q_0022881</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Part of the SF3A subcomplex of the 17S U2 SnRNP complex which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP). SF3A1 functions as a scaffold that interacts directly with both SF3A2 and SF3A3. Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex. Identified in the spliceosome 'A' and 'B' complexes. Identified in the spliceosome 'C' complex. Interacts with P2RX6; resulting in a reduction of the splicing activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004053">
        <property type="protein sequence ID" value="KYO31818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006268991.1">
        <property type="nucleotide sequence ID" value="XM_006268929.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N4U6"/>
    <dbReference type="STRING" id="8496.A0A151N4U6"/>
    <dbReference type="GeneID" id="102565217"/>
    <dbReference type="KEGG" id="amj:102565217"/>
    <dbReference type="CTD" id="10291"/>
    <dbReference type="eggNOG" id="KOG0007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N4U6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01800">
        <property type="entry name" value="Ubl_SF3a120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000091">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035563">
        <property type="entry name" value="SF3As1_ubi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SURP motif" evidence="16">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="16">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="15">
        <location>
            <begin position="701"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="314"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="484"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="526"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KYO31818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="787" mass="88344" checksum="668F52C3172FA35B" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5C2</accession>
    <name>A0A151N5C2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RFC2</name>
        <name evidence="10" type="ORF">Y1Q_0007066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006260270.2">
        <property type="nucleotide sequence ID" value="XM_006260208.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5C2"/>
    <dbReference type="STRING" id="8496.A0A151N5C2"/>
    <dbReference type="GeneID" id="102558373"/>
    <dbReference type="KEGG" id="amj:102558373"/>
    <dbReference type="CTD" id="5982"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000006">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="54"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO32043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="340" mass="37593" checksum="3AE02ED840605F46" modified="2016-06-08" version="1">MRAGMAAAEPGPAPGGSAHYELPWVEKYRPQALAEIVGNEDTVSRLQVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILARLMKIVEKEDVPYADDGLEAIIFTAQGDMRQALNNLQSTYSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWRLGYSPEDIIGNVFRVCKTFQMPEYLKLEFIKEIGYTHMKIMEGVNSLLQMAGLLGRLCQKTAAPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N5N1</accession>
    <name>A0A151N5N1_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Y1Q_0007117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N5N1"/>
    <dbReference type="STRING" id="8496.A0A151N5N1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF27">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN BETA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24694">
        <property type="entry name" value="LNS2_PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24695">
        <property type="entry name" value="PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585752" description="DDHD domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="DDHD" evidence="6">
        <location>
            <begin position="388"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KYO32108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="767" mass="83619" checksum="07306B54891C8462" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N696</accession>
    <name>A0A151N696_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Y1Q_0007068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03004004">
        <property type="protein sequence ID" value="KYO32045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N696"/>
    <dbReference type="STRING" id="8496.A0A151N696"/>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000002">
        <property type="entry name" value="CAP-Gly domain containing linker protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000001">
        <property type="entry name" value="Putative CAP-Gly domain-containing linker protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF10">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="408"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="515"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="644"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="905"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KYO32045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1015" mass="114041" checksum="EA65C0940ED1170A" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N6N0</accession>
    <name>A0A151N6N0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clusterin-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLUAP1</name>
        <name evidence="9" type="ORF">Y1Q_0020356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLUAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003917">
        <property type="protein sequence ID" value="KYO32397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006273183.1">
        <property type="nucleotide sequence ID" value="XM_006273121.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N6N0"/>
    <dbReference type="STRING" id="8496.A0A151N6N0"/>
    <dbReference type="GeneID" id="102560102"/>
    <dbReference type="KEGG" id="amj:102560102"/>
    <dbReference type="CTD" id="23059"/>
    <dbReference type="eggNOG" id="KOG3647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="PhylomeDB" id="A0A151N6N0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019366">
        <property type="entry name" value="Clusterin-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547">
        <property type="entry name" value="CLUSTERIN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547:SF0">
        <property type="entry name" value="CLUSTERIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10234">
        <property type="entry name" value="Cluap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="208"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KYO32397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="412" mass="48127" checksum="2F7001BBB41634A6" modified="2016-06-08" version="1">MSFRDLRNFTEMMRALGYPRLISMENFRTPNFMLISEMLLWLVKRYEPQTDIPSDVETEQDRVFFIKAVAQIMATKAHIKLNTKKLYQADGYAVKELVKITSVLYNAMKTKGMETTEVEEEDGSKFKFDLGSKIADLKAARQLASEITSKGASLYDLLGKEVELREVRTESIARPLEINEAEKVMQIAIKDILEQVQKTKDMLNNVALDEANLEVKIEKRKLELERNQKRLQTLQSVRPAFMDEYEKIEEELQKQYSSYLEKFRNLTYLEQQLDDHHRIEQERFEEAENTLRLMQNRLKEEEKRLLKTGSNDDSDIEIQEDEGSDSEVEDRQLMKHHTAMEIPMQVKLNKRVMGTMQGGDIENDEDSEDSEIDLDDDEEEDDIEDDSVEISPSKANRRARKPEPLEESDNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9L2</accession>
    <name>A0A151N9L2_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone deacetylase</fullName>
            <ecNumber evidence="3 12">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Y1Q_0008697</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 12"/>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9L2"/>
    <dbReference type="STRING" id="8496.A0A151N9L2"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10162">
        <property type="entry name" value="ClassIIa_HDAC4_Gln-rich-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10006">
        <property type="entry name" value="HDAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000002">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046949">
        <property type="entry name" value="HDAC4/5/7/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024643">
        <property type="entry name" value="Hist_deacetylase_Gln_rich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364:SF13">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364">
        <property type="entry name" value="HISTONE DEACETYLASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12203">
        <property type="entry name" value="HDAC4_Gln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037911">
        <property type="entry name" value="HDAC_II_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase glutamine rich N-terminal" evidence="18">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="17">
        <location>
            <begin position="611"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="202"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="995"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Contributes to catalysis" evidence="15">
        <location>
            <position position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037911-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KYO33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1020" mass="112793" checksum="A9760A11D7D6FADC" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151N9N9</accession>
    <name>A0A151N9N9_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0008725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003682">
        <property type="protein sequence ID" value="KYO33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151N9N9"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="75" mass="8269" checksum="851B73694B0D403D" modified="2016-06-08" version="1">MQQQRVADSFRLQAYILSTISQLTLYCIYESLPSLVSIGVSGNPSQSRMIAPMGQLCISLLKAKVKASPIYGKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NAU1</accession>
    <name>A0A151NAU1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0024515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003627">
        <property type="protein sequence ID" value="KYO33896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NAU1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO33896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="100" mass="11179" checksum="C757703F2BD01826" modified="2016-06-08" version="1">MVFKETPNLDLEISMIDVSIITWGDQPLLLKNDLSLLLLMSKLVSLKNLKRFKACSMLNAAVADVHLCKSSFHLFTAATDVGKARIANLLFQISKKYLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NC71</accession>
    <name>A0A151NC71_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Interleukin-17F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">IL17F</name>
        <name evidence="8" type="ORF">Y1Q_0012990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003504">
        <property type="protein sequence ID" value="KYO34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NC71"/>
    <dbReference type="STRING" id="8496.A0A151NC71"/>
    <dbReference type="GeneID" id="102564959"/>
    <dbReference type="KEGG" id="amj:102564959"/>
    <dbReference type="eggNOG" id="ENOG502S5A0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6093351at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020440">
        <property type="entry name" value="IL-17_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01932">
        <property type="entry name" value="INTRLEUKIN17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585928" evidence="7">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KYO34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="171" mass="19556" checksum="B22E6FA4FF88D9BD" modified="2016-06-08" version="1">MKTFLRSPALFSSLLLVLILMLSTKNSAHGRAVGPQLNKGRSSEQKTRDDCPTEIDSLFPTSVEVSINISNTNDTTKMAQDVNLRSLSPWNYSFTKDPNRFPQVIIEAKCRHYSCVDSTGREDYRMNSVPIRQEILVLRRKLRDCQYVYRLEKQLITVGCTCVMPLIQHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NDB4</accession>
    <name>A0A151NDB4_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Y1Q_0010533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003332">
        <property type="protein sequence ID" value="KYO34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NDB4"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001872">
        <property type="term" value="F:(1-&gt;3)-beta-D-glucan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071226">
        <property type="term" value="P:cellular response to molecule of fungal origin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042808">
        <property type="entry name" value="CLEC7A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47218:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007585965" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="377"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KYO34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="452" mass="49682" checksum="10594509214AE5A9" modified="2016-06-08" version="1">MPTLTQFTSPWGTLLFILLLNPGHCSLPWRYSQPSPESLPAESKPAALDLLGMHGQDDASSDLRLETPPELQRQIPRHAGHREPAPASPPWSPIPLVLGIMLVCLLFLITARVYGAQMAQLGIERKSLLEQVGYLSSELTSCQNQGIPGTVRELPHDIGTDVSVCQPGTEKENPVMEGKHHTPKPTSYQKPSPPGTSRKQPQDTGEKCPALWTAKQDRVSSPQGLMNMLKIVEVVHTTTHSGLDCRLTSEKESGSGQTIQLFTLTYPSATPLRWQLATLVLGILCLILLTATAVLGYNVCQPGTEQENPVKEGEQHTSQPTSYQKPSLPGTSIMQPQDTGQKYAALWTAKQDRSYLFAPQRGTWKQYRGSSLYYYPFWIGLSFDSRKAKWVWADASAVSSGLFVLLDPSPQNYPGGACAYLQGDKVKLGGCGENQFCICKKKKEAQIKNKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NE06</accession>
    <name>A0A151NE06_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0000936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003207">
        <property type="protein sequence ID" value="KYO35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NE06"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="113" mass="12755" checksum="A9C0535445F89D05" modified="2016-06-08" version="1">MYYPYGVSTVRFAGASQKPNKRHCEWQLQAEAGVVLPGAWCLQRHRRQLESNRRTIKGRISLCDLSPRREQPPFPAQVSQDFETPPQPGVTCLPGFLKHGAQPVRTKTLAQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NEP0</accession>
    <name>A0A151NEP0_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03003201">
        <property type="protein sequence ID" value="KYO35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NEP0"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO35254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="241" mass="26848" checksum="7251938FF8B48771" modified="2016-06-08" version="1">MDVRMAVECSQDWPLVWGRSKDAYWPHDIITCTAAQEALHVCLNAVLQHTRKQMQCFSRGRGMILKPAHSWVASGILLAASKQGLATGEQFAGQSWVASPAHAAQPQLYKCAANRLHRWFHRVPLLGLRESSVYRPSAIRVLLQKQGGGGCECTLGFQPCCPESPMTPHASHCQQRQLKSFAGLQESLTITALLWAHGALGRGHPPERDLGECLKIWWLLWSFSVWEILAAGGWLSHCHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NHZ6</accession>
    <name>A0A151NHZ6_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0024175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002956">
        <property type="protein sequence ID" value="KYO36431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NHZ6"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO36431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="103" mass="12048" checksum="7FA108E99409EF50" modified="2016-06-08" version="1">MNGSFKNIILDKKRQESTRRPGSSREDIQCGWPTEAGKEDEPSFHRLIRRHAPKQSISVPQEESRRENMANHWMKGTLMTCIYGSLIATQMFQKTYHLDGYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NJ12</accession>
    <name>A0A151NJ12_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Di-N-acetylchitobiase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CTBS</name>
        <name evidence="18" type="ORF">Y1Q_0020834</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002907">
        <property type="protein sequence ID" value="KYO36782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="8496.A0A151NJ12"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071391">
        <property type="term" value="P:cellular response to estrogen stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032355">
        <property type="term" value="P:response to estradiol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000006">
        <property type="entry name" value="Chitobiase, di-N-acetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000250">
        <property type="entry name" value="Probable di-N-acetylchitobiase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.20:FF:000002">
        <property type="entry name" value="Vitellogenin 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.230.10:FF:000002">
        <property type="entry name" value="Vitellogenin 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.90.10">
        <property type="entry name" value="Vitellinogen, beta-sheet shell domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015258">
        <property type="entry name" value="Vitellinogen_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037088">
        <property type="entry name" value="Vitellinogen_b-sht_shell_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09175">
        <property type="entry name" value="Vit_b-sht_shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01170">
        <property type="entry name" value="DUF1944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0758">Storage protein</keyword>
    <feature type="domain" description="Vitellogenin" evidence="15">
        <location>
            <begin position="11"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="16">
        <location>
            <begin position="1385"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="1511"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1084"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1135"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1084"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1150"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KYO36782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="1950" mass="219348" checksum="DF331D80F9983058" modified="2016-06-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NK25</accession>
    <name>A0A151NK25_ALLMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="23">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Y1Q_0008437</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:18322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:24814"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="23"/>
    <dbReference type="EMBL" id="AKHW03002822">
        <property type="protein sequence ID" value="KYO37161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NK25"/>
    <dbReference type="STRING" id="8496.A0A151NK25"/>
    <dbReference type="KEGG" id="amj:102565773"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF39">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 23" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 23" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15 23" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 22" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="20">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KYO37161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="400" mass="44457" checksum="BCA52EE94870FDE8" modified="2016-06-08" version="1">MAAVAAPGTWARARLGVLPGRVCAALTALLGSQRPFSSIFKASDLQVELSQHLKPQPDPGALVFGKNFTDHMLTVEWSQERGWGRPYIKPFQNLTLHPASSALHYSVELFEGMKAFRGTDQRIRLFRPTLNMERMYRSAMRACLPAFDQAELLECICQLISIDQDWVPCSDSASLYIRPTFIGTEPSLGVSKSGYALLFVILGPVGPYFPTGSFSPISLLADPRFIRAWMGGVGDCKVGGNYGPTIYVQNEAAKKGCQQVLWLYGDDHQVTEVGTMNIFMYWTDEHGDLELVTPPLNGIILPGVVRQSLLDLGRKWGEFKVSERVFTMADLLKGLHENRVKEVFGSGTACVVCPINHILYQGQSYHIPTMENGPDVAKRFLKELTDIQYGRVSSDWVHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NLK3</accession>
    <name>A0A151NLK3_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MTSS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Y1Q_0009425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002733">
        <property type="protein sequence ID" value="KYO37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NLK3"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007586165" evidence="2">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KYO37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="281" mass="31134" checksum="14163354B45C79C1" modified="2016-06-08" version="1">MLNCFLWFLWCFTRGGASRTCRAPRLCSKNCRAVHQKPPRTTQLAHSPFPYMTDKFSRLENHQLPKSPPAFGLPWARPGKLQPPPCQTIFDTFPDRRPLKRIWYPGLGGTAMGFPTQKPSFPLRATVKVKKSAPSFQGCQSVRAREILHLLENSSPPLVSEIEFHLSVFVEKMKRALWRDLEDPASPAGVIAPDVQELTKETTASAAVIKDLKGSKDSSYRTLPSSPNSTSSHRSSTCSLAQLVSANTCLSSITSDHSSFISQNAMYSKLPSPMPSDITSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NN99</accession>
    <name>A0A151NN99_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0007298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002528">
        <property type="protein sequence ID" value="KYO38190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NN99"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="84" mass="9818" checksum="1E17C4D4CFF0BAF3" modified="2016-06-08" version="1">MQKRRSTGTQEIDGIWLREGTRRRFLKTDLPEKLEKGVVETASIISFINGSTTSRRHNEDADALSLTRHFRKTNMKNYIVLHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NNX1</accession>
    <name>A0A151NNX1_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Y1Q_0011402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002466">
        <property type="protein sequence ID" value="KYO38542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NNX1"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KYO38542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="191" mass="20717" checksum="C8D253020AA57909" modified="2016-06-08" version="1">MEGDPASLGHEVSKPCPSPSLSSSSSQGDLDSSVESGSNPPYGTTMKVIPYRPGEEVEEEQEGEDLMLLEEEALTDIILHLQGQGKDKEHGDRFLLAIPALCRATKQRGEDTLEPETCQVVLLQKIMVSLAVHWALWGVGGRRDRGSQGQEGGVHTGEGRHARALTREHGEGKFWAKAIQDSGRILHLEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NP97</accession>
    <name>A0A151NP97_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Y1Q_0015699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002524">
        <property type="protein sequence ID" value="KYO38469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NP97"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KYO38469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000050525"/>
        </source>
    </evidence>
    <sequence length="93" mass="11073" checksum="8EEAF129CF610568" modified="2016-06-08" version="1">MMWSWFHNSQSSFCAQGQPRCGKKQDLTHWSKSRYSERKSHTQHPQLPWVSAPHAHLVPFLRCEMDLKNFNSGSELPKISVNINQLWIWVWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-06-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A151NQ58</accession>
    <name>A0A151NQ58_ALLMI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Inter-alpha-trypsin inhibitor heavy chain H5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ITIH5</name>
        <name evidence="12" type="ORF">Y1Q_0023461</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Alligator mississippiensis</name>
        <name type="common">American alligator</name>
        <dbReference type="NCBI Taxonomy" id="8496"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Archelosauria</taxon>
            <taxon>Archosauria</taxon>
            <taxon>Crocodylia</taxon>
            <taxon>Alligatoridae</taxon>
            <taxon>Alligatorinae</taxon>
            <taxon>Alligator</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Genome Biol." volume="13" first="415" last="415">
            <title>Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.</title>
            <authorList>
                <person name="St John J.A."/>
                <person name="Braun E.L."/>
                <person name="Isberg S.R."/>
                <person name="Miles L.G."/>
                <person name="Chong A.Y."/>
                <person name="Gongora J."/>
                <person name="Dalzell P."/>
                <person name="Moran C."/>
                <person name="Bed'hom B."/>
                <person name="Abzhanov A."/>
                <person name="Burgess S.C."/>
                <person name="Cooksey A.M."/>
                <person name="Castoe T.A."/>
                <person name="Crawford N.G."/>
                <person name="Densmore L.D."/>
                <person name="Drew J.C."/>
                <person name="Edwards S.V."/>
                <person name="Faircloth B.C."/>
                <person name="Fujita M.K."/>
                <person name="Greenwold M.J."/>
                <person name="Hoffmann F.G."/>
                <person name="Howard J.M."/>
                <person name="Iguchi T."/>
                <person name="Janes D.E."/>
                <person name="Khan S.Y."/>
                <person name="Kohno S."/>
                <person name="de Koning A.J."/>
                <person name="Lance S.L."/>
                <person name="McCarthy F.M."/>
                <person name="McCormack J.E."/>
                <person name="Merchant M.E."/>
                <person name="Peterson D.G."/>
                <person name="Pollock D.D."/>
                <person name="Pourmand N."/>
                <person name="Raney B.J."/>
                <person name="Roessler K.A."/>
                <person name="Sanford J.R."/>
                <person name="Sawyer R.H."/>
                <person name="Schmidt C.J."/>
                <person name="Triplett E.W."/>
                <person name="Tuberville T.D."/>
                <person name="Venegas-Anaya M."/>
                <person name="Howard J.T."/>
                <person name="Jarvis E.D."/>
                <person name="Guillette L.J.Jr."/>
                <person name="Glenn T.C."/>
                <person name="Green R.E."/>
                <person name="Ray D.A."/>
            </authorList>
            <dbReference type="PubMed" id="22293439"/>
            <dbReference type="DOI" id="10.1186/gb-2012-13-1-415"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">KSC_2009_1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITIH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AKHW03002440">
        <property type="protein sequence ID" value="KYO38779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006264798.2">
        <property type="nucleotide sequence ID" value="XM_006264736.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A151NQ58"/>
    <dbReference type="STRING" id="8496.A0A151NQ58"/>
    <dbReference type="GeneID" id="102561312"/>
    <dbReference type="KEGG" id="amj:102561312"/>
    <dbReference type="CTD" id="80760"/>
    <dbReference type="eggNOG" id="ENOG502QPS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000050525">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030212">
        <property type="term" value="P:hyaluronan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01461">
        <property type="entry name" value="vWA_interalpha_trypsin_inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000013">
        <property type="entry name" value="inter-alpha-trypsin inhibitor heavy chain H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010600">
        <property type="entry name" value="ITI_HC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF62">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06668">
        <property type="entry name" value="ITI_HC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type=